LOCUS       c00194_gnlPro..        14917 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FJCFCKGF_194.
ACCESSION   c00194_gnlPro..
VERSION     c00194_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 13:21:21
            Original ID  :: gnl|Prokka|FJCFCKGF_194
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 6746
            Orig. end    :: 21663
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14917
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[16746:21604]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14858
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14917
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14917
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(778..1140)
                     /locus_tag="ctg194_8"
                     /transl_table=11
                     /translation="MAKMLIEDFKGVVPSDIDELQKLPGVGRKTANVIASVVYDKPAMA
                     VDTHVFRVSNRIGLTNNSKTPLETEKELVKNIPEELIPIAHHWLILHGRYVCLARKPKC
                     EECGLKPWCKHFLKQT"
     CDS             complement(1383..1550)
                     /locus_tag="ctg194_9"
                     /transl_table=11
                     /translation="MEEGDRYFFIYSYNSGVSYFWHISACIFLLKVIPLGCEKQKPKKQ
                     CEKKKGIKAY"
     CDS             complement(1585..4098)
                     /locus_tag="ctg194_10"
                     /transl_table=11
                     /translation="MKTLKYLLATMLLLGVCNLTHSQKLSLGIFPEPQEVTISSQTYAP
                     SHGYTLRGINNPDADAVKLLKEALPFAKSGKSLPLEIKKLKDKTPEMQRSGAYTLTITK
                     KGIMIGIVDDNSLFYAAQTLKQLAKYDEGKKILPLCSIKDYPDVLFRGTVEGFYGQPWS
                     HADRIEQIRFYGRIKLNTYIYGPKDDPYHSSPNWRKPYPAEEAEHIKELAEEATHNKVN
                     FVWAIHPGQDIQWNLTDSMNILSKFEKMYDLGVRSFAVFFDDISGEGARPEKQAGLLNY
                     IHKEFITKKNDVQPLIMCPTEYNRSWAKTDYLDILGTQLDPAIQIMWTGDRVVADITKE
                     GVEWVNNRIRRPAYIWWNFPVSDYCQDHLLMGPAYGLDTQAAGTMTGFVSNPMEYAEAS
                     KVAIFGVGMYTWNIENYDPTQAWKDACDFIMPEASMAFRIFCEHNCDPGPNGHQYRREE
                     SANYVAPIQTFLAGYKKNTFPEQSANLLGTLFAQITASPSMIYSQSPNKRLIEQINPWL
                     IQFEFLGKAGTSALHMAHAWYEKDRSYTWQRYLETSALLDSMKLINRTLNQKAQPKGVK
                     VGSKVLHPFIVDLYRQTGRNLLSTDGIAPDEVKVSIPSIFTNIDQLKSQPCAEGDNTVG
                     YVPLFEVVKVQPNQYLGIGWEIQKEAESFCFNLPKSNQPGRVFEWSADGKSWSLIPHVS
                     TENAKDTIRTIDPKARYIRMRNNSDQQMELYVLGFTATTKQDPQINEALMMYDMNLDTY
                     KNLNPGEMIHIKCDDINAVSFFLSGSNENLVSITGLSQDGEKNIVYQGNVGYIKLNKTM
                     FEDFSSLEITTIGKESIHIHQIVRE"
     CDS             complement(4200..5783)
                     /locus_tag="ctg194_11"
                     /transl_table=11
                     /translation="MIKITYKLILLLSLLAMTVTSFAASEAEYGKVSKAWTLHADGSQE
                     YRSSMELTLFTHTAMNSTYGESFIVYNPDFQTLKIHSSYTRQKDGTIVKTPDNAFVEVL
                     PRFAADAPAYNQLKEMVVVHTGLELGATIYLDYSIITKPGYYPALDINERLQETSPVKE
                     CKVSISVPEGTPLACGLYGSPVKAVEESHDGIKEVHWTLRNIPASSREAFQPKNREASP
                     HLVASTYPSGKAALATLDKRLKESQGYESKTFAQFLTDKSGNEQEKVNIIRDHILNNLS
                     TCPIPMAMTGYTVRDIDTVLRSAYGTPLEIAQLLNVMLNAAGIPSEVLAVYPGHLDTDA
                     CGLAAIQTLAVKATVDGKDQYLSASPLTNRGGLDKVVSLSGTSIEIETTPIQIKESRSV
                     AISADQAKDGFAICVLPAISAGIDSWGMSALNSKRSNLFELPSLIREEVTYTVTPAEGM
                     KLQTSTKEQVISKPFGKVTRTITPKGNTIEVVRTIELNKQQFTPAEYSGVRSLIHEWTN
                     PDNRVLLFSL"
     CDS             complement(5797..7755)
                     /locus_tag="ctg194_12"
                     /transl_table=11
                     /translation="MKRILTITAVSLLALSPMYGQDSCRYPQDPTLEKSQAYAGYDCVT
                     LLDSTAVTVQPTGSGAFAVCKAFKVQTPKGAVANRIIKYDYDPLTAHAEFRYATIYRAN
                     GDVINLDVTGACDYAAPARAIYWGARQIMLEVGRLQPGDVVEYEIAKKGFTYALLTAGD
                     DERFIPPMRGQFYDIVPFWATEPTVRKVYRVSMPMEKELQFQFYQGECTSSMRYEDGRK
                     VYTFASDDILPFAKEPNMVDLFDAAPKLMMSSTPRWEDKSVWFNKVNEDYGSFTAIPEA
                     QRKVDELIKGKKTEMEKIAVLTHWVADNIRYSGISMGKGEGFTLHNLKMNYTDRCGVCK
                     DIAGTLIAFLRMAGFEAYPAMTMAGSRVESIPADHFNHCVAVVKLASGTYMPLDPTWVP
                     FCRELWSSAEQQQNYLPGVPEGSDLCLTPVSAPENHYVRIHADNRLDEKGTLRGQFTIT
                     AEGQSDSNIRRIFTTGWQSDWQNTMEKQLLAVSPNAKLLRVDYGKDPKNYQAAPIKITF
                     SYEIPDYAIIAGDQMLIKPLVMNNLYNQVKSFLRIDTKPENRAYGFKDACSRLVEQDET
                     IRLPKGYTLLNAPKNDALRSNAADFEGSLSQEGDRNIVLRQKLALKKRVYDAADWKGFR
                     SAVNAYKSYGDYLIIKK"
     CDS             complement(7758..8894)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 51.2; E-value:
                     2.4e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg194_13"
                     /sec_met_domain="AMP-binding (E-value: 7.4e-17, bitscore:
                     51.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIQEDLQAFLAEWHDPSPFLEVQTSGSTGTPKRMRVRKDRMLNS
                     ARLTCDYLGLKKGDKALLCMPLRYIAGKMMVVRSLYAGLDLEVREPSGHPLADWGDTPL
                     RFAAMIPLQVYNTLRVPEERKRLEQTDILIIGGGAIDAALEQEIRQMPNTVYSTYGMTE
                     TLSHVALRRLNGPEASPYYHPFSSVTLSLSPDNTLVIDAPLVCDERLVTNDVARLLPDG
                     SFAIIGRKDNIINSGGIKIQIEEVEERLRPYLDLPYAITAAPDPRLGEAVVLLIAPRSC
                     ETVSPPRVTPHMKAIMSDSWNLSCTANESYHERFMKAITNDSAQLSCEVSTVALASLPK
                     YLRPRHVIEASEIPQTGSGKIDRAACRELARNIITKTL"
     CDS             complement(8898..9956)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg194_14"
                     /sec_met_domain="MR_MLE_C (E-value: 8.2e-30, bitscore:
                     94.3, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKERFYKTEVVPRCLTFKQPAGTSRGVYTTRKLWEVRIRKEDEP
                     SVIGIGECAPLPDLSCDYGVDYEITLSKACLDLEHEGYVDTESLRHYPSILFGLETAMR
                     HYEQGGWRHYDTPFSRGQAGIPINGLIWMGDYKYMLEQVEEKMKEGFRCVKLKIGAIDF
                     DRELSLLKHIRAHFSAKEIELRVDANGAFTPSEAMDKLKRLAEMDLHSIEQPIRAGQLE
                     EMAHLAAESPLPIALDEELIGCNAPDEKRRLLETIHPQYIILKPSLHGGIAGCTEWVHL
                     AETILGSTPERPKWWVTSALESQIGLNAIAQWCATLGNPLPQGLGTGEIFKDDKHRLIQ
                     RKGDTIWFTNDL"
     CDS             complement(10001..10825)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg194_15"
                     /sec_met_domain="ECH_1 (E-value: 5e-82, bitscore: 265.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
     CDS             complement(10829..12184)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg194_16"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9e-08, bitscore:
                     22.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLEL
                     NHHGKGPVHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRM
                     MIAGQMSLIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKL
                     VPELVITYGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDAFEFLEK
                     IAYMLENRQIEYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRY
                     AQLYTVPETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGN
                     LHNNLRILLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNA
                     EELAAAMSAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             complement(12532..13110)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg194_17"
                     /sec_met_domain="Chorismate_bind (E-value: 9e-47, bitscore:
                     150.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQ
                     LVASYIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPA
                     VCGLPKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGG
                     GLLAASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             13288..13419
                     /locus_tag="ctg194_18"
                     /transl_table=11
                     /translation="MVSVSFLLLGFGWDFDFIRREFVFLSREIPIGFGGDFKAIRLD"
     CDS             complement(13626..14858)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg194_19"
                     /sec_met_domain="HBT (E-value: 2.7e-17, bitscore: 53.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDKKEITPRTHAALLKAQQMGVHVVLASGR
                     PTNGVQPLAEALELNHYGGFILSYNGGQIINAQTGELMFEKRIDPAMIPYLNRKAKENG
                     FAIFTYHKDYILTDSPENKHVQEEAELNKMRIIGVENFPEAVDFAPCKCILTSDDENNL
                     VGLENHWKKRLDGVLEAFRSEDYFLEVAPHFINKGNTLAVLMEMLNITTEEVVAIGDGV
                     ADVSMLQLAGTGVAMGNARDSVKACADFTTLSNNMDGVAVAIEKAILATIKPTEVPLDQ
                     LNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDIFTSTDKLVSS
                     VRVINSILKKK"
ORIGIN
        1 tatcgcataa attggggtaa aagttctcca aggctttctc atagggttgc tcgttgaagc
       61 agcaaaggct tccttcatta tagaataaat ccattgccaa ccattgattt ttcattctcc
      121 actccgtcga gtcattcatt tgtacccgta aatgtaaagg ggcgcttttg atgaagagat
      181 tcattgcgcc acgcttgcct tttttacgaa tcagatctgt tagttccgga atgacatgtg
      241 cggggtatgt ctgttgcctt tccaccgtct ctaccaataa tcttcggttg taggacgcta
      301 cgaatatacc ctcgtggtag taacaaccta gaaaatgctt atcaacatca ggataatatc
      361 taacaggaac ggaggtttcc tctcgttgct gggccggaaa agtgaaagag acgtccagtt
      421 gcttgaaaat acgctctgcc gtatgactat ccataggggc gtacaagaca tccccttgtg
      481 gataataagc gattaggaaa gacgataatt ccagattttg ccgtattaaa gaaaggaaaa
      541 tagcgggggt atgatctgag aacgccttgc gtatattctc catgggtagt atcatcttct
      601 cgaatacagg aggacgattg atggcaaaaa ttgccgtggg gcttggaacg accaaactat
      661 agggatctac cgtagcgaca aattgctcgt cgttcatatg cttgtaaaag tacctcacgc
      721 atacgatcgt acccagaaac aagacaaaaa atgccgttat gtctttcttg ctgatcctca
      781 tgtttgcttt aggaagtgtt tacaccaagg ctttaatccg cattcctcac atttcggttt
      841 ccgggcgagg caaacatatc ttccatgcaa tatcaaccag tgatgggcga tggggatcaa
      901 ttcttccgga atgttcttca ccaactcctt ttccgtttcc aaaggtgtct tgctattatt
      961 ggtcaagccg atccggttgg agacacggaa tacgtgcgta tccaccgcca tggccggctt
     1021 gtcatatact acggatgcga ttacgttcgc tgtttttctt cctacgcccg gcagtttttg
     1081 tagctcatca atatcggagg gaaccacgcc tttgaaatcc tctatcagca ttttcgccat
     1141 acctaccaga tgtttagcct tattgttcgg gtaagatacg cttcgtatgt attcaaagac
     1201 aacttccggt gtgctagccg ccattacctc aggagtcggg aaagcctcga acagggcagg
     1261 tgtgatcata ttcactcgct tatccgtgca ttgtgcggat aggattaccg ctatcaatag
     1321 ttgatagggg tcgtcataat gtagttcagt ctcggctacc ggtacgtttt ccttaaacca
     1381 gtttaatacg cctttatacc tttcttcttt tcgcattgct ttttcggttt ctgtttttcg
     1441 catcctaaag gtataacttt taataggaat atacaagcgg agatgtgcca aaaataagat
     1501 acacccgaat tgtacgaata aataaaaaag taccgatctc cttcttccat ctaagagaga
     1561 aagaaatcgg tactttttta tttattattc cctaacgatc tggtggatat gtatagattc
     1621 ttttcctatt gtggtgattt ctaaagaaga gaaatcctcg aacatggttt tatttaattt
     1681 gatgtagcct acgtttcctt gatagacgat gtttttctcg ccatcttggg agaggccggt
     1741 gatggatacc agattctcgt tacttccgga gaggaagaaa gatacggcgt tgatatcatc
     1801 acattttata tgaatcattt ctcccgggtt caagttctta tacgtatcta ggttcatatc
     1861 gtacatcata agagcctcat tgatttgcgg gtcttgtttg gttgtcgccg tgaatcctag
     1921 tacgtatagc tccatttgct gatccgagtt atttcgcata cggatataac gggctttcgg
     1981 gtcgatggtg cggatcgtat ctttagcgtt ttccgtggag acatgaggga ttaggctcca
     2041 gctctttccg tcggcggacc actcgaatac ccgtccgggt tggttgcttt tcggaagatt
     2101 gaaacagaag gattccgctt ctttctggat ttcccagccg atacccagat attggttagg
     2161 ttgtaccttg actacctcga ataggggaac gtaaccgacc gtattgtcac cctcggcaca
     2221 aggctggctc tttaattggt cgatattcgt gaatatggaa gggatgctaa ccttcacctc
     2281 gtccggggcg ataccgtccg tagatagcag gttacgacct gtctggcggt ataagtctac
     2341 gatgaaaggg tgtaagactt tcgatccgac tttcacgcct ttaggctgcg ccttctggtt
     2401 cagcgtgcgg tttatcagtt tcatgctatc tagcaaagcg gatgtttcca gatagcgttg
     2461 ccacgtataa gaccggtctt tctcatacca agcgtgcgcc atatgcagag cgcttgttcc
     2521 ggcttttcct aagaactcga attggataag ccatggattg atttgctcga tcaagcgttt
     2581 attgggactt tggctataga tcatactcgg ggaagccgtg atttgagcga ataaggttcc
     2641 cagaagattc gcgctttgct ccgggaacgt gtttttctta tatccggcga ggaatgtctg
     2701 gataggagcc acatagttag cggactcttc ccggcggtat tgatgtccgt tcggacccgg
     2761 atcgcagtta tgctcgcaga aaatgcggaa agccatggag gcctccggca tgatgaagtc
     2821 gcaagcgtct ttccatgcct gtgtaggatc gtaattctcg atattccaag tgtacattcc
     2881 aacgccgaat atagcgacct tggaagcctc ggcgtattcc ataggattgg atacgaatcc
     2941 ggtcatggtg ccggcggctt gcgtatctag gccgtaggcg ggtcccatca acaaatgatc
     3001 ttggcaataa tcgcttacgg ggaagttcca ccagatatag gcgggacgac ggatacggtt
     3061 gtttacccac tcgacgcctt ctttcgtgat atcggctacg acacggtctc cggtccacat
     3121 gatttggata gcggggtcga gttgggtacc gaggatatcc agataatcgg tcttagccca
     3181 tgagcggttg tattcggtag ggcacatgat caggggctgc acgtcatttt tcttggtaat
     3241 aaactcctta tggatgtaat tcaataagcc ggcttgcttt tccgggcggg ctccctctcc
     3301 ggatatatca tcgaagaaaa cggcgaaaga gcgtacgccc aaatcgtaca ttttctcgaa
     3361 tttggaaagg atgttcatgc tatctgtcag gttccattga atatcttgtc ccgggtggat
     3421 ggcccaaacg aagtttactt tgttatgggt ggcctcttcc gctagttcct tgatatgctc
     3481 ggcttcctcg gcgggataag gtttgcgcca gttgggggag ctgtgataag gatcatcttt
     3541 cggaccatag atataggtgt tcagcttgat ccttccgtaa aagcggattt gctcgatacg
     3601 gtcggcgtgg ctccaaggct gtccgtagaa tccttccacg gtaccccgga ataatacgtc
     3661 cggatagtcc ttgatcgagc agagaggcag gatcttctta ccctcgtcat atttagctaa
     3721 ttgcttgagg gtttgggcgg cgtaaaacaa ggaattatcg tctacgatcc cgatcatgat
     3781 acctttttta gtgatcgtca gcgtataggc acctgagcgt tgcatttccg gagttttgtc
     3841 ttttagcttc ttgatctcta aagggagaga tttgccggat ttagcaaaag gtagcgcttc
     3901 tttaagtagt ttgaccgcat ctgcgtccgg attatttata ccccgtaggg tatatccatg
     3961 ggacggtgcg tatgtttggc tggaaatagt cacctcttgg ggctcgggga agattcctag
     4021 ggatagcttt tggctatgcg ttaggttaca aacgcctaga aggagcatgg tggcgagtaa
     4081 atactttagt gtcttcatat acgatatgat ttaatgttaa cgttcgtaaa tgtatgaaat
     4141 aattaaacac ggagcacacg gaatacacag atttgttccg tgccctccgt atttagatct
     4201 tatagggaga atagcaatac ccggttatcc ggatttgtcc attcatggat caagctacgc
     4261 acgccgctgt attcggcggg agtgaactgt tgcttgttca actcgatcgt acgtaccacc
     4321 tcaatcgtat ttcctttcgg agtgatcgtg cgggttactt taccaaaagg cttgcttatc
     4381 acttgctctt ttgtggaggt ctgcaacttc atgccctcgg cgggagtaac cgtgtatgtt
     4441 acctcttccc tgattaggga ggggagttcg aataagttgg aacgcttgct gttcaaggca
     4501 ctcatgcccc agctatcgat tccggcggag atggctggca atacgcagat ggcgaaaccg
     4561 tcttttgctt gatcggcgga gatggccacg gatctacttt ccttaatctg aataggtgtg
     4621 gtctcaatct caatggaagt tccggagagg gagactacct tatctagtcc gccacgattt
     4681 gtcagcgggg aggcggatag gtattggtct ttcccatcga cagtggcttt tacggctagt
     4741 gtctggatgg cagccagccc gcaagcgtcc gtatcgagat ggccgggata gacggcgagg
     4801 acttccgacg ggattccggc ggcattcaac atcacgttca agagctgtgc gatctctagc
     4861 ggcgtaccgt aggcactgcg gagaacggta tcgatgtcac ggacggtata gccggtcatc
     4921 gccatgggga taggacaggt actgagattg ttgagtatat ggtctcggat gatgttcacc
     4981 ttctcttgtt cgttaccgct tttatcggtg aggaattggg cgaaggtttt gctctcgtat
     5041 ccctgcgatt cctttaagcg cttatccaaa gtggctaagg ccgctttacc tgaaggatag
     5101 gtagaggcta ccaagtgggg tgaagcctca cggttctttg gttggaaagc ctcacgggag
     5161 gaagcgggaa tgttccgtag tgtccagtgt acctccttta taccgtcatg gctctcttcc
     5221 acggctttta cgggggagcc gtatagaccg caagccaagg gggtcccttc cggtacggaa
     5281 atagagacct tgcattcctt cacgggagag gtctcttgta gtcgctcgtt gatatccaga
     5341 gccggatagt aacccggttt tgtgataata gagtaatcca agtaaatcgt ggccccaagt
     5401 tctaggccag tgtgtaccac gaccatttcc ttaagttggt tataggccgg agcgtcggcg
     5461 gcgaaacggg gcaggacctc cacgaaggcg ttatcgggtg tctttacgat cgtaccgtct
     5521 ttctgcctcg tataggatga gtgaatcttc agtgtttgga aatcgggatt gtagacgata
     5581 aaactctcgc catacgtgct attcatcgcg gtatgcgtga agagcgtcaa ctccatggag
     5641 gatcgatatt cttggctgcc gtcggcatgc aaggtccaag ctttcgatac tttcccgtac
     5701 tcagcctccg atgcggcgaa tgaagtaacc gtcatcgcta acaagcttag gagaagaatc
     5761 agtttatagg ttatcttaat cattgtcttt ctttttttat ttcttgataa tcaaatagtc
     5821 accataactc ttataggcgt tcacggcgga acggaagcct ttccagtcag ccgcgtcgta
     5881 gacacgcttc ttcaacgcta gcttctggcg caagacgatg ttccggtcgc cttcctgtga
     5941 aagggaacct tcgaaatcgg ccgcattgct tcgcagggcg tcattcttcg gggcgttcag
     6001 gagggtatag cctttgggga gacggatggt ctcatcttgt tctaccaaac gggagcaagc
     6061 gtccttgaat ccatacgcac ggttttccgg tttcgtatcg atacgcaaga aactcttcac
     6121 ttgattgtag aggttattca tgactagcgg cttgataagc atctggtctc cggcgatgat
     6181 cgcataatcg gggatctcat aagagaacgt gatcttgata ggggccgctt gatagttctt
     6241 cgggtcctta ccgtaatcta cacgaagcag tttggcgttg ggggatacgg ccagcaattg
     6301 cttctccatc gtgttctgcc agtcggattg ccatccggtg gtgaagatgc ggcggatatt
     6361 gctgtcggac tgtccctcgg cggtgatcgt gaattgtccg cggagcgtgc ctttctcgtc
     6421 taggcggttg tcagcgtgga tgcggacgta gtggttttct ggggcggaga caggggtcag
     6481 gcagaggtcg gagccttcgg gcacacccgg gaggtagttc tgctgttgct cggcgctact
     6541 ccataattcc cggcagaaag gaacccaagt cgggtcgaga ggcatatacg tgccgctagc
     6601 cagttttacc accgccacgc aatggttgaa atggtcggcg gggatgcttt ctacacggct
     6661 tcccgccatg gtcatcgccg ggtaagcctc gaatccggcc atgcggagga aggcgatcaa
     6721 cgtaccggcg atatccttgc agacaccgca acgatcggta taattcatct ttaggttgtg
     6781 aagcgtgaaa ccctcgcctt tacccatcga gatcccggag taacggatgt tatcggccac
     6841 ccagtgggtc agcacggcta tcttctccat ttccgtcttc ttgcctttga tcagctcgtc
     6901 taccttcctt tgggcttccg ggatcgcggt aaagcttccg taatcctcgt taaccttatt
     6961 gaaccatacg gatttatctt cccagcgggg cgtgctggac atcatgagct tcggggctgc
     7021 gtcgaatagg tctaccatat tcggttcctt ggcgaaagga aggatatcgt cggaggcgaa
     7081 ggtatatact ttccgtccat cctcatatcg catggaagag gtacattcgc cttggtagaa
     7141 ctggaattgc aactctttct ccatcggcat ggatacccgg tataccttac gcacggtagg
     7201 ctcggtagcc cagaagggga cgatatcgta aaactgtccc cgcataggag ggatgaaacg
     7261 ctcgtcgtcg cccgccgtca gcaaggcgta ggtgaaacct ttcttggcga tctcgtactc
     7321 cacgacatct cccggttgca ggcggcccac ttccagcatg atctgccggg cgccccagta
     7381 gatggcacgt gcgggggcgg catagtcgca agccccagtc acgtcgagat tgatcacgtc
     7441 gccattcgca cggtagatcg tggcgtaacg aaactcggca tgcgccgtca gcgggtcgta
     7501 atcgtatttg atgatacggt tggcgacggc tcccttggga gtctgtacct taaaagcctt
     7561 gcatacggcg aaagcccccg agccggtagg ttgtaccgtg acggcggtgc tgtccagcaa
     7621 ggtgacgcag tcgtatcctg cgtaggcttg cgatttctcc aaggtaggat cttgcgggta
     7681 tcggcaagaa tcctgcccgt acataggcga taaggccaat agggagaccg cggtgattgt
     7741 tagaatcctt ttcatgttta tagtgttttt gtgatgatat ttctcgctag ctcccggcag
     7801 gcggcacgat cgatcttgcc gcttccggtt tgggggatct cgcttgcctc tatgacgtgc
     7861 cttggacgga ggtacttggg caggctggcg agagccactg tcgatacctc acatgatagc
     7921 tgcgcggagt cgttcgtgat agctttcatg aatcgctcat gatagctttc attagcggta
     7981 catgataggt tccatgagtc gctcatgata gctttcatgt gtggtgtcac ccgagggggt
     8041 gataccgttt cacatgacct tggggcgatt agtaagacta ccgcctctcc caaccgaggg
     8101 tcgggggcgg cggtgatggc ataggggagg tctaggtagg gccgtagccg ctcttccacc
     8161 tcctcgatct gtatcttgat acctccgcta ttgatgatat tatctttcct tccgataatg
     8221 gcgaaactcc cgtccggcag caggcgggcg acatcgttcg tcaccagccg ctcgtcgcaa
     8281 accaatgggg cgtctatcac caaggtattg tccggcgaca aggataacgt caccgaggag
     8341 aagggatggt aatagggcga ggcttccggc ccgttcagcc ggcgcagggc gacgtgagac
     8401 agcgtctccg tcattccgta ggtggaataa accgtgtttg gcatctgccg tatctcctgt
     8461 tccaaggccg cgtcgatcgc cccgccgccg ataatcagga tatccgtttg ctccagccgt
     8521 ttacgttcct cgggtactcg caacgtattg taaacctgca aggggatcat ggcggcaaag
     8581 cgcaggggcg tatcccccca atccgccaac gggtgtccgg agggctcacg cacctccaga
     8641 tccagtccgg cgtataggga gcggaccacc atcatctttc cggctatata gcgcaggggc
     8701 atacataaca gggccttgtc gcccttctta agacccagat aatcgcaggt aagccgggcg
     8761 ctgttcagca tccggtcctt gcgcactctc atccgcttgg gcgtaccggt ggagccggag
     8821 gtctggactt ccagaaaagg ggagggatcg tgccattcag ctaagaatgc ctgtaaatct
     8881 tcttgtatcg gcataggtca aaggtcgtta gtgaaccaga tggtgtctcc ttttcgttgg
     8941 attaaccgat gtttatcatc cttgaaaatc tcgccggttc ccagaccttg cggtagcggg
     9001 ttacctaacg tggcgcacca ttgggcgata gcgttcagtc cgatttgcga ttccagagcg
     9061 gaggtgaccc accatttggg tcgctcgggg gtactcccta agatagtttc cgctaagtga
     9121 acccattccg tacatccggc gatgcctccg tggagggaag gctttaatat aatgtattgg
     9181 ggatggatcg tttccaacaa ccgccgtttc tcgtccgggg cgttacagcc gatcagttcc
     9241 tcgtcgagag cgatgggaag gggtgactct gccgcaaggt gtgccatttc ttccaactgc
     9301 ccggcacgga taggctgctc gatggaatgc aagtccatct cggcgagccg cttcagtttg
     9361 tccatcgcct ccgagggtgt gaaagcgccg ttggcgtcta cccgaagctc tatttccttg
     9421 gcagagaaat gcgcacggat gtgtttcaat aaagagagtt cccggtcgaa atcgatagcg
     9481 ccgatcttca gcttgacgca gcggaagccc tccttcatct tttcctctac ctgttccaac
     9541 atgtacttat aatcgcccat ccagatcagt ccgttgatgg ggatgcccgc ctgcccccgc
     9601 gagaagggcg tgtcgtaatg ccgccaaccg ccctgttcat aatggcgcat ggccgtctcc
     9661 agcccgaaaa ggatggatgg gtaatggcgc aaagattcgg tgtcaacata tccctcatgt
     9721 tccagatcga ggcaagcctt ggataacgtg atctcgtaat ccactccata atcgcaactg
     9781 agatccggca ggggggcaca ttctccgata ccaataaccg agggttcgtc ttccttgcgg
     9841 attcggacct cccacaattt ccgggtcgtg taaacacccc gtgaggttcc tgccggttgc
     9901 ttgaaagtca agcaccgggg aaccacctct gtcttataaa acctctcctt caccattcat
     9961 tttcaatttt caattttcaa ttctcaattc tcaattccct ttacgggaac ttcgggtaat
    10021 cctcgaagcg tggacggcgt ttctccaaga atgccttgcc gccttcctgc gcctcgtccg
    10081 tcatatagta aagcatggta gcgtctccgg ccaactcctg tataccggcc tgtccgtcca
    10141 actcggcgtt caagcctgcc ttgatcatgc gcaaggccaa cgggctaagc aacatcatct
    10201 cctcggccca ttgaacgtac tcgtcctcta atttatccaa ggggactacc ttatttacca
    10261 gacccatatc caaagcctcc tgtgcattgt acttgcggca taggaaccag atctcacggg
    10321 cctttttttg tccgaccaca cgggcgaggt aagaagagcc gaacccggcg tcgaagctac
    10381 ccacacgagg gcctgtctgt ccgaagatag cgttctcgga agcgatcgta aggtcacaaa
    10441 ccacgtgcaa tacgtgtccg ccgccgatag cgaaaccgtt cacggctgcg atgacgggtt
    10501 tcgggagaga gcggatctgc ttttgtacgt ccaatacgtt caagcgaggt acgccgtctt
    10561 tacccacgta gccgccacgt cctttcacgt tcatatcgcc tcccgcgcaa aacgccgtat
    10621 ctccggctcc tgtcagaacg actacgttaa tgtccggacg ttcccggcag atgtaaaagg
    10681 cgtcgctcat ctccgtggtc gtagtcgggg taaaagcgtt gcgataccgt tcccggttta
    10741 tcgtaatgcg ggcgatgccg ttgtagaaat caaataagat ctcctcgtat tccttgatgg
    10801 ttgtccattc tcttttcgtt tccatatatt atatgttttg tgcttgggat gaatttttta
    10861 gttgatgata atattccttg agcaatcgta cgtcttccgc tttgtccgtg aaaacctcca
    10921 tgaatagggg atgttcgctc ggttgctccg tttgggtaaa ggcgctcatc gcagctgcca
    10981 actcctcggc gttatgaacg gcggagtagg agaatcccct ttccgtggcc catccctccg
    11041 ctgaggtctg gtgggaggcg gtgacgtaac ggtgcgtacg ctcgttcatc ttgaatcctg
    11101 gcaaggcttg gaagatctca ccacctccgt tgttcaagag caggatacga aggttattgt
    11161 gcaagtttcc gttccacaac gcattcatat catagaagaa actaagatcg cctataacga
    11221 taaagtttag tttttgcgag gccgaggcgt atccgatagc cgtagacaag gagccttcga
    11281 tcccgctcgt acctcggtta caacaaacct caaccgtctc gggtacggtg tacaattgtg
    11341 cgtaacgtac ggtggagcta ttccccagat gcaaggccga ttcagccgga agcgaacgta
    11401 tcaaaccacc gatcgccgcc atttcggagt aagcgaactc cggctccggc agattccggg
    11461 atttatattc ccaagccttc ggatattcaa tctgcctatt ctccagcata taagcgattt
    11521 tctccagaaa ctcgaaagcg tccatctcga tcaccgtggt caggctaccg aataaatccg
    11581 ctacctcccc atccaatgag acatgccaat gctccttagg cgggtgtttc cgcaaaaact
    11641 ctttcagccg cttggagaca atatggccgc cgtaggtgat cacgagctcg ggaaccagct
    11701 tctctttttc ctcctctggg gtagcgtaca ggatggcgtc gaaattcttg atcggcaatc
    11761 ccggtacgat acggttgccg atgtgctcgg agagccaagt gaaatgtttg tatagtaact
    11821 tacatatttt cttctcgaag agatagatca aactcatttg tcccgctatc atcattcgct
    11881 tgctatattt gttcaaacgc tcgatcagat cgtcatattt ccggtcgtac acgtttaggc
    11941 cttgataacg ggtgattacc cgtaccttcg gcaattcggg tgtcgtgaac tgaaataaag
    12001 gctcggagat cgggacgttg atatgaaccg gccctttgcc gtgatggttc agttccaaca
    12061 aagcctcgtt gatcaatcga ttacaatacc attcatcttg atccgtatgt atttccggta
    12121 gctgtaccga tttcttcacc agcgagccga acaccccggg ttgcggcaag gtctgtccgt
    12181 ccatttgccc gatccatgcg gcggggcggt cggcggatat cacgacaagc ggaactttct
    12241 gatagaaagc ctccgctacc gccggatgta tattcagcaa ggccgtgccc gaggtacagc
    12301 aaacagccgc cggcttacct ccgtgcaacg ctagccctac ggcaaagaat cccgcgcttc
    12361 gctcatccgt cacggaatgg caattgaaga acgaatggtt tgccaatgtg tgcacaatcg
    12421 gagagttccg gctccccgga catagcacga tattacttac gccgtgctct atcagcaagg
    12481 ctaccaattg aaggatgttc tttttatcgc tatacattat atgatataaa attataaatt
    12541 acccactatt ctccgcatcg tatctaattt atcctctgtc tcctgccact catcctctag
    12601 ctgcgaggcc gccaacagac cgcctccggc atacagcgta aaggtttggg ggaggatatt
    12661 catgcaacgg aggtttacgt acagatctgt tttgcctttg ggatccagcc aaccgatgaa
    12721 accggagtaa tagctacgat cgtacccctc attctcgatg atgaaatgat aagcctcctc
    12781 cttgggaaga ccgcaaacgg ctggagtagg gtgtaatagt tgaaggacat cacccagctt
    12841 ctcgggattc ggcaaggaga agaagaaatc gcttttcaaa tgggaaacct ctccggcccg
    12901 ggctgaataa ggccccttct cctcgggagt aatacccaag gtggacagct ggcggcgtat
    12961 ataggaggcg actaattgct gttctctcca attcttatgg tcccagcttt tcggtaattt
    13021 cccgtctcgt aaggattggg ttccggccaa agctaccgtt tgccagtcgc ctttctcgcc
    13081 ggataacaag atttccggtg tcccacccat ccaagttccg gtttccgggg tatggcaaag
    13141 gtagacatag gagcggatat atcgttctac tgcggcgaag aatgccttgc cgggtgagaa
    13201 agagggatct ttccggatcg ttttgctacg ggataggact agtttatctt ggcttccttt
    13261 tagcaaaggg ctggtaaaca gggagaaatg gtaagcgtat cgttccttct cctcggattc
    13321 ggatgggatt tcgatttcat tcgaagggaa ttcgtttttc tctcgagaga aatcccaatc
    13381 ggattcggag gggatttcaa agcaatccgg ttggattaaa acgataggtc gttccgctgt
    13441 cacctgaaac ggagcgatta caaaaccgct ccgttcattt aagtctttta tgtcgtataa
    13501 taggcaagga gagccggcgc tttgcatcct gaaatggagc ctatcctcac cgggaatacg
    13561 ccaaatagcg aaactccggc cttgcttgat caacgtgtct attatttcgt aagaatctct
    13621 tggaatcatt tcttctttag tatgctattg attacccgta ccgaggaaac cagtttgtcg
    13681 gtagaggtga atatgtctac gttccacaca tgggatgaac ggcctttgtg gataatcgtc
    13741 ccgacggcac gtaccgtgtc tccctcgtgg gcggacgaca tatggctgcc gctaacttgc
    13801 atgccgacta ccatctcgtc cggtttcgcc agaatcatgg aacctagtcc ggccacggtc
    13861 tccgccaaag ccagcgtagc gcctccgtgc aagataccga aaggctggcg ggtccgttcg
    13921 tctacaggca tggtcgcttc cacacgatcc tccgacgcat aggtatattg aatgcctaga
    13981 ttacccatta aggcatgttt ggcccgtgcg tttagttgat ctaacggaac ctccgtgggt
    14041 ttgatcgtgg caaggatcgc tttctcgatc gctaccgcca caccatccat attattagat
    14101 aaggtcgtga aatcggcgca agcctttacg gagtcgcgtg cgttacccat cgccacgccg
    14161 gtaccggcta attgaagcat ggatacgtcg gctacgccat caccaatagc gacaacctct
    14221 tcggtcgtga tattcagcat ctccatcaat accgccaacg tatttccctt attgatgaaa
    14281 tgaggagcta cctccaagaa atagtcctcg gagcggaaag cttccaatac cccgtccaga
    14341 cgtttcttcc aatgattttc gagacccact agattgttct cgtcatcgct ggtaagaata
    14401 cacttacagg gtgcgaaatc caccgcttcc gggaaattct ccacaccgat gatgcgcatc
    14461 ttattgagtt cggcctcctc ttggacatgc ttgttttccg ggctatcggt caggatatag
    14521 tccttgtgat acgtgaagat agcaaaaccg ttttccttcg ccttccggtt caaataagga
    14581 atcatggccg gatcgattcg tttctcgaac atcaattctc cggtctgggc attgatgatc
    14641 tgacctccgt tataagataa tatgaaacca ccgtaatgat tcaattcaag agcctccgcc
    14701 aagggttgaa ccccgttggt gggtcggccg gatgccaata caacatgaac tcccatctgc
    14761 tgagccttta acagggcggc atgggtccgg ggagttatct ctttcttgtc gttaagcaac
    14821 gtcccatcta cgtctaagac taataatttg tacttcatgg cgtcttattt tatggtttag
    14881 aatacaaagt tactacaaaa aagtgaaatg cggaaag
//
