LOCUS       c00047_gnlPro..        14984 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OLLNFHLF_47.
ACCESSION   c00047_gnlPro..
VERSION     c00047_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 12:07:45
            Original ID  :: gnl|Prokka|OLLNFHLF_47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14984
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..186
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_1"
                     /sec_met_domain="ILVD_EDD (E-value: 3.6e-13, bitscore:
                     41.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="KDGDIIEINIPERTINVRLTDEELAARPMTPVTRERYVPKSLKAY
                     ASMVSSADKGAVRLID"
     protocluster    1..14984
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4984]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4984
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14984
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14984
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             242..1939
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8e-47, bitscore:
                     151.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDIISGGEALMRSLEYHGVKTIFGYPGGSIMPVFDALYDHRET
                     LNHILVRHEQGAAHAAQGFARASGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTAFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVPWAVARAFYIAKSGRPGPVVLD
                     FAKNAQVEKAEYMPAKLDFIRSYVPVPETDPEAVKAAAELINGAERPLVLVGQGVELGN
                     AQQELRAFIEKADMPAGCTLLGLSALPTEHPLNKGMLGMHGNLGPNMNTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEINKNVHADVAVLGNCKETLSAVTALLQPNE
                     HKEWLDSFLPYEQVEEEKVIRPELHPMGDTLSMGEVVRAVSDATNHEAILVTDVGQNQM
                     MSARYFKYSKDRSMITSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIIVLNNNFLGNVRQWQAMFFNRKYSFTPMLNPDYIKIASAYDIPAKRVF
                     TREELADAIDEMIATDGPFLLEACVIEEGNVLPMTPPGGSVNQMLLEC"
     CDS             1953..2513
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_3"
                     /sec_met_domain="ALS_ss_C (E-value: 3.3e-18, bitscore:
                     58.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVVKQIEKKIDVLQAHYFTEDEIYFHEIALYKVSMPEFQSQPE
                     ASKVIRRYNARIVEVNPVFAIVEKNGISEEITSLYEELSALNCVLQFVRSGRVAITTSC
                     FERVNEFLADRETKYNLSKKEEK"
     CDS             2514..3257
                     /locus_tag="ctg47_4"
                     /transl_table=11
                     /translation="MSDDKKIGSYKFIAEPFHVDFNGRLTMGVLGNHLLNCAGFHASER
                     GFGIATLNEDNYTWVLSRLAIDLEEMPYQYEEFTVQTWVENVYRLFTDRNFAIIDKDGK
                     KIGYARSVWAMINLNTRKPADLLTLHGGSIVDYVCDEPCPIEKPSRIKVATDQPCAKLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIDLYKSKRIQRFEMAYVAESYYGDELSFFEEEV
                     SENEYHVEIKKNGSEVVCRAKVKFV"
     CDS             3275..3859
                     /locus_tag="ctg47_5"
                     /transl_table=11
                     /translation="MKKIVFLLLLCVACCMNAQEFHLIPKVGLNLANTTGEVDSKVRPG
                     LNIGLGGDVMLTERFGIETGVYYSMQGSKYKGGGVSYTDKLDYINVPVYAKEFIYKGLY
                     VFGGPQFSFNVNSENKSSSDYGTTVIGMNVIRKFDCGVGLGAGYQFERGLLISLNYNIG
                     LINVNKSWASDSNPKANNSVVQLNVGWRFAL"
     CDS             3941..4984
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_6"
                     /sec_met_domain="IlvN (E-value: 8.1e-45, bitscore: 145.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 8.2e-40, bitscore: 129.1,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVTENVVTREEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPQKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGRAMERTIALGIGVGSGYLFETTFVREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVQKLYNSVKTGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             5187..7106
                     /locus_tag="ctg47_7"
                     /transl_table=11
                     /translation="MKNRIYTMKGMLATLLGAFLLGYAVTGCIDEKDHYKPDDKTSGVP
                     NSFDFATTQDVQLDLKYDVPVKDYQVLFELYFENPLTTDAEGQVVKRTDITPKVTRMTD
                     GTGKYRAKETVPAYGEEVYIYTSYIGVPMLYKTKVVGNTITADINWDTAAEESVQTRAE
                     GEYQTVPQGFYTLGSWNVKGRPNYLDSEGVIELTSSFYQTINQTIPEGGNCPRKYRQSA
                     DIVINDELGAEVKVRFVGGTSAAYSAFGYYCYPEGAAKKQIENAKKYVVFPNTKTGVGI
                     KGGECVKLHYIDENGEDQGTTFPKGTKIGWFISNDAFTKKGEKTGSVGKGLGMFYSTTA
                     LNSDGRTHTAAFKINDFIVLSFEDWTDQDYNDVMFNIWSNPIEAIAPDVPSVDPIDPDD
                     ASVAYRMTYKGILAFEDNWPSKGDYDLNDVIVKYSSILEFNTKNQVLSAEDTFTAMWSG
                     ALFKNGFAYQLNTDRSNVECSILEGKSGWDKQGLDKDLEQATISVFANAIEETGENTKT
                     STFKIQNKFKQPVDHETFGVAPYNPFIFLHQNTDKNRTEVHLVNHGPTSKENMDLFNTQ
                     QDLSDKDKGIYYVSDQNYPFAIHLSDVESFSTTEKEAIDKSYPRFASWAQSGGTTDKDW
                     YLKQ"
     CDS             complement(7219..9123)
                     /locus_tag="ctg47_8"
                     /transl_table=11
                     /translation="MNDNKIKSSSPLSDLQHQQLLLRMEYEYEKEEFRRQTETMGIARK
                     VKRGLCWYPVGTGRSFYNSLNQLVIEIERKEDKDIEHVFEFGRPVCFFEQGYDGKIHYF
                     NSICTVSYADEERMVVAVPGAGSLLEIQGAERLGVQLYFDETSYHTMFEALEDVIRAKG
                     NRLAELRDILLSKQPSRWRETYPVRFPWLNSTQEAAVNKVLCAKDVAIVHGPPGTGKTT
                     TLVEAIYETLHRENQVLVCAQSNTAVDWIAEKLVDRGVPVLRIGNPSRVNDKMLSFTYE
                     RRFEGHPAYTELWGIRKSIREMGNRMRKSSYSEREAAHSRINHLRERATELEIQINEDL
                     FSGARVIASTLVSSNHRILTGRRFTTLFIDEAAQALEAACWIAIRKADRVIFAGDHCQL
                     PPTIKCIEAARNGLEQTLMEKVAANKQETVSLLKVQYRMHQSIMQFSSEWFYQGELQAA
                     PEVTNRGILDLDLPMSWIDTSEMEFHEEFVGESFGRINKPEANLLLQELEAYIRKIGEK
                     RVLEERIDFGLISPYKAQVQYLRGKLKGCLFFRPFRSQITIHTVDGFQGQERDVIFISL
                     VRANEDGQIGFLNDLRRMNVAITRARMKLVILGDAVTMSKHAFYKKLIGYIRHISQGL"
     CDS             9382..11625
                     /locus_tag="ctg47_9"
                     /transl_table=11
                     /translation="MVYDLNMLKSFYASYKGKMEHVRAALKRPLTLAEKILYTHLYNVA
                     DLKNYERGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEAVAVPSTVHCDHLIQAYRGA
                     ERDIETATQTNREVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPKLIGVRLTGELNGWTAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMAVYLKATGRE
                     EVAAMADSVAADLRADDEVMARPDDFYDRVIEINLSELEPYINGPFTPDAATPISEFAE
                     KVVTNGYPRKMEVGLIGSCTNSSYQDISRAASVARQVNEKNLGVAAPLIVNPGSEQIRA
                     TAERDGMMDVFEKMGATIMANACGPCIGQWKRHTDDPTRKNSIVTSFNRNFAKRADGNP
                     NTFAFVASPEIVLALTIAGDLCFNPLKDRLVNHDGEKVKLSEPQGDELPSAGFVAGNQG
                     YQAPGGEKNEIRVAPDSQRLQLLTPFPAWDGNDFLNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRLTNTYETVSGTAKQYKADGISSIVVAEE
                     NYGEGSSREHAAMEPRFLHVKVILAKSFARIHETNLKKQGMLAVTFADKADYDRIREHD
                     LISVVGLKEFSPGRNLEVILHHEDGTEERFAVQHTYNEQQIGWFRAGSALNAK"
     CDS             11788..12978
                     /locus_tag="ctg47_10"
                     /transl_table=11
                     /translation="MSKITKQQNGVLSVPDVPTIPFITGDGVGAEITPAMQAIVDAAVD
                     MSYGGARRIEWKEVLAGERAFRATGSWLPDETMEVFKEYLIGIKGPLTTPVGGGIRSLN
                     VALRQTLDLYVCLRPVRWFRGVVSPVKEPEKVNMYIFRENTEDIYAGIEWEAGTPEAKK
                     FYRFLHEEMGVSKVRFPETSSFGVKPVSREGTERLVRAACRYALQHELPSVTLVHKGNI
                     MKFTEGGFKKWGYELAEREFADALASGKLVIKDCIADAFLQNTLLIPEEYSVIATLNLN
                     GDYISDQLAAMVGGIGIAPGANINYDSGHAIFEATHGTAPNIAGKNVVNPCSLILSAVM
                     MLEYIGWQEPADLIVEALEASFAEGKATNDLARFMHKGQPLSTSEFTREIINRIKN"
     CDS             12991..14334
                     /locus_tag="ctg47_11"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEAMKDCTRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDLEDLAHAILKEKRFGFEEVAYLLLSGSL
                     PDKEELASFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPNPDDTSRD
                     NLMRQSIDLISKFPTIIAYAFNMLRHATFGRSLHIRHPQENLSIAENFLYMLKRDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRAVLLKEL
                     ARDLAHEKGREREFAFLELLEERAIATFGKIKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     YTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLEEEQYVPLKKR"
ORIGIN
        1 aaggatggtg atatcatcga aatcaatatc cccgaacgga ctatcaacgt gcgactgacc
       61 gatgaagaac tggctgcacg tccgatgact ccggtcactc gtgaacgcta tgtgcctaaa
      121 agtcttaaag cgtatgccag catggtaagc tctgccgata aaggagcggt gagactgatt
      181 gattaaccac agagttgttt caatcgtgaa ttgtaaatcg taaaatcgta aattttagta
      241 catgagtaaa gatataattt caggcggtga agcattaatg cgttctttgg aatatcatgg
      301 tgtaaagacg atctttggtt atcccggagg atctatcatg cccgtattcg atgccttata
      361 cgatcataga gagactttga atcatatttt ggttcgccac gaacaagggg cggcacatgc
      421 ggctcaggga tttgcccgtg cttcgggtga ggtcggagtt tgcctggtga cgagcggccc
      481 cggtgctacc aataccataa ccggtattgc ggatgcaatg atcgacagta caccgattgt
      541 agtcattgcc ggacaggtgg gaacagcttt tttggggaca gatgcttttc aggaggtcga
      601 cttggtaggc atcacgcagc caattacaaa atggagttat cagatccgtc gtgccgaaga
      661 tgtgccatgg gcggtggccc gcgcctttta tatagcgaaa agcggacgcc cgggaccggt
      721 agtgctcgac tttgcaaaaa atgcccaggt ggagaaagcc gaatatatgc ctgcgaaact
      781 cgatttcata cgcagttacg tgcctgtacc cgagactgac ccggaggccg tgaaagcggc
      841 tgccgaatta attaacggtg cagagcgccc gttggtattg gtggggcaag gtgtggaact
      901 gggcaacgca caacaggaat tgcgtgcttt catcgaaaag gcagatatgc ccgccggatg
      961 tacgttgttg ggactgtcgg ctttgccgac cgagcatcct ttgaacaaag gtatgctggg
     1021 aatgcacggt aatctcggac cgaatatgaa caccaataaa tgtgatgtcc tgattgctgt
     1081 cggcatgcgt tttgacgacc gtgtgaccgg aaacctggct acgtacgcca agcaggcgaa
     1141 agtgattcat tttgatatcg atccggctga aattaataag aatgtacatg cggatgtagc
     1201 ggttctgggt aactgtaaag agacgctctc tgctgttacg gcattgctgc agcccaacga
     1261 gcataaagaa tggctggaca gtttcctgcc ttatgaacag gtggaagaag aaaaggtaat
     1321 ccgtccggaa ttgcatccga tgggagatac gctttcgatg ggggaagtgg tgcgtgcggt
     1381 aagcgatgcg accaatcatg aagcgatatt ggtgaccgat gtcggtcaaa accagatgat
     1441 gtctgcccga tactttaaat attcaaaaga ccggagcatg attacttccg gaggacttgg
     1501 taccatggga ttcgggttgc cggctgctat cggtgcaacc tttggccgac cggaccgtac
     1561 ggtttgtgta tttatgggtg acggtggtct gcaaatgaac attcaggagt tgggaaccat
     1621 tatggaacag aaggcaccgg ttaaaattat cgtattaaac aataatttcc tgggcaatgt
     1681 acgccaatgg caggcaatgt tcttcaaccg taaatactcg ttcacaccca tgctgaaccc
     1741 cgattatatt aagattgctt ctgcttatga tataccggcc aaaagagtct ttacccgtga
     1801 agaactggct gatgcgattg acgagatgat tgcgacagac ggtccgttcc tgttggaagc
     1861 ttgtgtgatt gaagagggaa atgtgttgcc gatgacccct ccgggaggtt cagttaacca
     1921 gatgttgttg gaatgctaat aagttaggaa ttatggataa gacattatat acattaattg
     1981 ttcattcaga gaactttgcc ggattgttga atcaggttac ggcagtattt acccgtcggc
     2041 agattaatat agaaagcctg aatgtttcgg cttcatctat caagggggtg cataaatata
     2101 ctattacggc ttggaccgat aaagatacga tagagaaggt tgtcaaacag attgagaaga
     2161 agatcgatgt gcttcaggca cattatttca ctgaagatga aatctatttt catgaaatag
     2221 ctctttataa ggtgtctatg cccgaatttc agtcacagcc ggaagcttcg aaggtgattc
     2281 gtcgctataa tgcacggatt gtggaagtga atccggtatt tgccatcgtt gagaaaaatg
     2341 gaatcagtga agaaattact tctctctacg aagagttgag tgcattgaat tgtgtgttgc
     2401 aatttgtacg ttcgggacgt gtggcaatca ctaccagttg ctttgaacgt gtgaacgagt
     2461 ttctggcaga tcgtgagacc aaatataact taagcaagaa agaggaaaag taaatgagtg
     2521 acgataagaa gatagggagt tataagttta ttgcggagcc ttttcatgta gacttcaacg
     2581 gacgtttgac aatgggggtg cttggcaacc atctgttgaa ctgtgccggc tttcatgcca
     2641 gtgaacgcgg ctttggaatc gctacattga atgaggacaa ttatacatgg gtattgtctc
     2701 gtctggccat cgatctggaa gagatgcctt atcaatatga ggagtttact gtacagacat
     2761 gggtggagaa tgtatatcgt ctttttactg atcgtaattt tgccattata gacaaggacg
     2821 gcaagaagat cggatatgcc cgttcggtat gggccatgat taatttaaat acccgcaagc
     2881 cggctgattt gctgacgttg catggcggta gtattgtgga ctatgtatgt gacgaacctt
     2941 gtccgatcga aaagccttcg cgtatcaaag tggctactga ccaaccttgt gctaagttga
     3001 cagctaaata cagcgatatc gacatcaatg gtcatgtgaa cagcattcgt tatatagaac
     3061 atatcctcga tttgtttccg atcgatttgt ataaatcgaa acggattcag cgatttgaaa
     3121 tggcctatgt ggcagaaagt tattatggcg acgagctttc tttttttgaa gaggaagtaa
     3181 gtgagaatga atatcacgtc gagattaaga aaaacggcag tgaagttgta tgccgggcaa
     3241 aagtgaagtt tgtgtagttt aaaatgtgat taaaatgaag aagattgttt ttcttttgct
     3301 gctctgtgtt gcttgctgca tgaatgcaca ggagtttcat ctgattccga aggtcggttt
     3361 gaatctggca aatactaccg gggaggtgga ttctaaagtg cgtcccggac tcaatatcgg
     3421 tctgggaggt gatgtcatgc tgaccgaacg gtttggaata gaaacaggag tgtattactc
     3481 catgcaggga agcaaatata aagggggcgg agtctcttat acggataaac tggattatat
     3541 caatgttccg gtatatgcga aagaatttat atataagggg ctgtatgtgt ttggagggcc
     3601 gcagttcagt ttcaatgtga actcagagaa caaatcatcc tccgactatg gtaccacagt
     3661 cataggcatg aatgtgattc gcaagtttga ttgtggagtg gggcttggag ccggttatca
     3721 gtttgaacgt ggtctgctga tctctctaaa ctataacatc ggactgatta acgtaaacaa
     3781 atcttgggca agcgactcta atcctaaagc aaacaatagt gtggtccagc taaatgtcgg
     3841 ttggcgtttt gcactgtaag ataaagaata taagtttaat tattaataat cggttttgtt
     3901 ttcgtccgaa cggaacaaga cttttaaaac aaaaagaaaa atggcacaat tgaattttgg
     3961 cggtgttacg gaaaatgtag taacccgtga agaatttcct ttggaaaaag ctcgtgaggt
     4021 attgaagaat gaaacaatcg ctgttatcgg ttacggtgtg cagggaccgg gtcaatcact
     4081 gaacctgcgc gataatggct tcaatgtaat cgttggtcag cgtccgggaa aaacatatga
     4141 aaaagcagtg gcagacggct gggttccggg tgaaacactg ttcggcatcg aagaggcatg
     4201 cgagaaaggt actattatta tgtgtctgtt gtcagatgca gccgtaatgt ctgtatggcc
     4261 tactatcaaa ccttacctga ctgccgggaa agcactctat ttctctcacg gtttcgcaat
     4321 tacatggagc gatcgcaccg gtgttgttcc acagaaagat attgatgtca ttatggtcgc
     4381 tccgaagggt tcgggtactt cactccgtac gatgttcctt gaaggtcgcg gactgaactc
     4441 ttcgtatgcc atctatcagg atgctaccgg cagagctatg gagagaacca tcgcattggg
     4501 tatcggcgta ggttccggat atctgtttga aacgactttt gtccgtgaag ctacttccga
     4561 cctgacaggt gaacgtggtt cgctgatggg agctatacaa ggtttgctgt tggctcagta
     4621 tgaggttttg cgtgagaacg gtcatactcc atctgaggca tttaacgaaa cggttgagga
     4681 gttaactcag tcattgatgc cgctgtttgc taagaatggt atggattgga tgtatgccaa
     4741 ctgctcgact acggctcagc gtggtgctct tgactggatg ggcccgttcc acgatgctat
     4801 taaacccgtt gttcagaaat tatataatag tgtaaagacc ggtaacgagg cacagatctc
     4861 tatcgactct aattcaaaac cggattatcg cgagaaactg gaggccgaac tgaaggcatt
     4921 gcgtgaaagc gaaatgtggc agacagctgt aactgttcgt aaacttcgtc cggagaataa
     4981 ttgatctgaa tagattatac aacttgtgat aaaaggagga aactgctgtt tcctcctttt
     5041 attttgcttg taattagtgt tttgtgtctg agttgttaga atggtatgtt gtagaatatg
     5101 aaaaatagat agattgtttg gatagataaa tcaagtttaa tatatatctt tgtgccctga
     5161 tcaaacaaca aacaatatta tatcatatga aaaatcgtat ttatacaatg aaagggatgc
     5221 tggctacatt actgggtgct tttttactag ggtatgcagt aacaggttgt attgatgaaa
     5281 aagatcatta taaaccggac gataaaacat caggagtgcc taactctttt gattttgcga
     5341 ctactcagga tgtccaattg gatctaaagt atgatgttcc tgtgaaagat tatcaggttt
     5401 tgtttgaact ctattttgaa aatccgttga cgacagatgc cgaagggcag gtggtgaaac
     5461 gtactgatat cactcccaag gttacgagaa tgactgatgg aaccggaaaa tatcgtgcca
     5521 aggagacggt accggcctat ggggaggagg tttatatcta tacttcttat atcggagtgc
     5581 cgatgttgta taagactaaa gtagtaggga atacgattac agccgatata aattgggata
     5641 cggcggcaga ggagtctgtt cagacacgtg ccgaaggcga gtatcagaca gtgcctcagg
     5701 gattttatac tttaggaagt tggaacgtga agggacgccc taattatctg gatagtgaag
     5761 gggtaataga attgacttct tcattttatc agacgattaa tcaaacaatt ccggaaggtg
     5821 gaaattgtcc tcggaaatat cggcaatcgg ctgacattgt tatcaacgat gaattgggag
     5881 ctgaagtgaa ggtgcgtttt gttggaggta caagtgctgc gtacagtgct ttcggatatt
     5941 attgttatcc ggaaggagcg gctaaaaaac agatagagaa tgctaagaag tatgtggtgt
     6001 ttcccaatac gaaaaccgga gtcggcataa aaggtggaga gtgtgtgaag ctgcattata
     6061 tcgatgaaaa tggtgaagac caagggacta cttttccaaa aggaacaaag ataggttggt
     6121 ttatcagtaa tgatgcattt acgaaaaagg gtgaaaagac cggcagtgtt ggtaaaggac
     6181 tcggaatgtt ttattcgacc actgccttga attcggatgg tcgtacccat acggctgcat
     6241 tcaagatcaa tgattttata gttttatcat ttgaagattg gactgatcag gattacaatg
     6301 atgtgatgtt taacatctgg tctaatccga ttgaagctat tgctccggat gtaccttcgg
     6361 tagatccgat agatccggat gatgcgtcgg ttgcttatcg catgacttat aaaggtattt
     6421 tggcttttga agacaattgg ccttctaagg gtgattacga tttgaacgat gtaattgtga
     6481 aatatagctc tatattagag ttcaatacca agaatcaggt gctttccgct gaagatacgt
     6541 ttacggcgat gtggtccgga gctctcttta agaatggctt tgcctatcag ttgaataccg
     6601 atagaagcaa tgtggaatgc agcatattgg aaggaaagtc gggatgggac aaacaaggat
     6661 tagacaaaga cttggagcag gccaccattt cggtgtttgc caatgcgatt gaagagacgg
     6721 gagagaacac taagacttct acttttaaga ttcagaacaa atttaaacag ccagtcgatc
     6781 atgaaacttt cggagtggca ccctacaatc cttttatctt cttgcatcag aatacggaca
     6841 agaaccgtac agaggtgcat ttggtaaatc acggaccaac ctctaaagaa aatatggatc
     6901 tgttcaatac ccagcaggat ttgtcggata aagataaagg catctattat gtgtccgatc
     6961 agaattatcc gtttgccatt catctgtctg atgtcgagtc attcagtaca acggagaagg
     7021 aagctattga taagtcgtat cctcgttttg cttcatgggc acaatccggc ggaacgacag
     7081 ataaggattg gtatttgaag caataagttg atgtcgtttt tatgctatag aacaaggggc
     7141 tgtccgaaaa tccgacagcc ccttgttcta tggttttaaa tggaaacaga agttacgact
     7201 gaaataagga gatcggcatc agagtccttg gctgatgtgc cggatatatc cgatcaattt
     7261 cttatagaaa gcatgcttgc tcattgtgac cgcatctcct aatataacca gtttcattcg
     7321 ggcgcgggtg atggctacgt tcattcggcg caagtcgttg agaaaaccga tttgtccatc
     7381 ttcgttagcg cggacgaggc tgatgaaaat gacatcacgc tcctgtccct gaaaaccatc
     7441 tactgtatgg atggtgatct ggctacggaa ggggcggaag aataaacagc ctttgagttt
     7501 tcctctcaga tactgtacct gcgctttgta aggggagata aggccgaagt ctatacgctc
     7561 ttccaataca cgcttctcac cgattttgcg gatgtatgct tcaagttctt gcaacaataa
     7621 gtttgcttcc ggtttattga tgcggccgaa gctttctcct acaaattctt cgtggaactc
     7681 catttcggag gtgtcaatcc aactcatggg caggtccaga tcgagtatcc cccggttggt
     7741 cacttcgggg gcggcttgta gttcgccttg gtagaaccat tcggaggaga attgcataat
     7801 agactgatgc atgcggtact gaactttcag gagtgagacc gtttcctgct tgttggctgc
     7861 tactttttcc attaatgttt gttccaaccc gttccgggcc gcttctatgc attttattgt
     7921 gggaggcaac tgacaatggt ctccggcaaa gatgacgcgg tctgcttttc ggatggctat
     7981 ccaacaggca gcctcaaggg cttgtgctgc ctcgtcgata aagagtgtgg taaatcgccg
     8041 gccggtcagg atacggtggt tactgctgac caatgtggaa gcgatgaccc gtgcccccga
     8101 aaacagatct tcattgattt gtatttccag ctccgtggca cgctccctca gatgattgat
     8161 gcggctgtgt gcagcttccc gttccgagta actgcttttg cgcatccggt ttcccatttc
     8221 ccggatcgac ttacgtattc cccagagttc ggtataggcc ggatgcccct cgaaacggcg
     8281 ttcgtaagta aatgaaagca tcttgtcatt tacccggctc ggattgccga tacgcaatac
     8341 aggcactccg cggtccacca gcttttcggc aatccagtcg acggccgtgt tgctttgtgc
     8401 acagaccagg acttgatttt cgcggtgcag ggtctcgtag atggcttcta caagagtggt
     8461 ggtctttccg gtccccggag gaccgtgaac gatggctacg tctttggcgc aaagtacttt
     8521 gttgactgct gcttcctgag tgctgttcaa ccaagggaaa cggaccggat aggtttccct
     8581 ccagcgggag ggttgcttgc ttagcaatat atcacgtagt tcggcaaggc ggttaccttt
     8641 ggcgcgaatc acatcttcca gcgcttcgaa catggtatga taggaggttt catcaaaata
     8701 gagttgtact cccagacgtt ctgctccttg tatttcaagt agagatccgg caccgggtac
     8761 ggctactacc atacgctcct cgtcggcata actgactgta cagatggaat tgaaataatg
     8821 tatttttccg tcatatccct gttcgaaaaa gcaaaccgga cgtccgaatt cgaatacatg
     8881 ttcgatgtct ttatcttctt tcctttctat ttcgatgacc aattggttca gtgaattgta
     8941 gaaactccgt cccgtcccga ccggatacca gcagagccct cgttttactt tccgtgcaat
     9001 gcccatcgtc tctgtctgcc ggcggaattc ttctttctcg tattcatatt ccatgcgtag
     9061 caaaagttgc tgatgctgaa gatcactgag tggagaagaa gactttattt tattatcatt
     9121 catcttgatt ggctgtaagt tatatgctaa gaactatagt tatggaatga ctacaaatta
     9181 cgaaaattat gcagaacctg tcacagtcac ttgtagcttg tagcatctga tttgtagcag
     9241 ctatacttat agcttctcac aaaatttccc gcaaagataa caattctgtt tccgggttgg
     9301 aataaacatt tcaatttgtt aaacctttct ttcatattat tggttataat aaatagaaga
     9361 acagataaaa ccgaaattgt tatggtatat gatttgaata tgttgaagag cttctatgct
     9421 tcctataaag ggaaaatgga gcatgttcgt gcagccttga aacgtccttt gacgttggct
     9481 gaaaagattt tgtatacaca tttgtataat gtggcggatt taaaaaatta tgaaaggggt
     9541 gaagactatg tcaactttcg cccggaccgc gttgctatgc aggatgctac tgctcagatg
     9601 gctctgttgc aatttatgaa tgcgggtaaa gaagcggtgg cagtaccttc cacggttcat
     9661 tgcgaccacc tgatacaagc ttatcggggg gctgaacgcg atattgaaac tgctacacaa
     9721 accaatcggg aggtgtacga ttttctgcgt gatgtctctt cccgttatgg catcggtttc
     9781 tggaaaccgg gagcgggtat cattcaccag gtagtacttg aaaattatgc ttttccgggt
     9841 gggatgatgg tcggtacaga ctcacatact cccaatgcag gaggtctcgg aatggtagct
     9901 atcggtgtag gcggagccga tgctgtggat gtaatgacag gtatggagtg ggaacttaag
     9961 atgccaaaac tgattggagt ccgtttgaca ggcgagttga acggatggac agctccgaaa
    10021 gacgtgatac tgaaactggc gggcatcttg accgtgaagg gtgggacgaa tgccattatc
    10081 gaatattttg gcccgggtac agcttcgcta tcggctacag gaaaggccac catctgcaat
    10141 atgggtgccg aagtgggggc aaccacttca ctattcccgt atgatgaacg gatggctgtt
    10201 tatctgaaag caaccggacg tgaagaagta gctgcgatgg ctgacagtgt agctgccgac
    10261 ttgcgtgcag atgacgaagt gatggcacga ccggacgatt tttatgaccg ggttattgag
    10321 ataaaccttt ccgaactgga accttatatt aatggtccgt ttactccgga cgctgctact
    10381 cctatttcag agtttgcaga gaaagtggta acaaacggtt atccccggaa gatggaagtg
    10441 gggttgatag gatcttgtac caactcttct tatcaggata tcagccgtgc cgcttctgtt
    10501 gcccggcagg tgaatgaaaa gaatctggga gtggcggcac cgctgattgt gaatccggga
    10561 tccgaacaga ttcgtgctac ggccgagcgt gacggcatga tggatgtgtt cgaaaagatg
    10621 ggagctacga ttatggctaa tgcctgtggt ccctgtatcg gacagtggaa acgccatacg
    10681 gacgatccga cccgtaaaaa ttcgatagtg acttccttta accgtaattt tgccaaacgt
    10741 gccgacggta atccgaatac ttttgctttt gtggcttctc ctgaaattgt tttggcattg
    10801 actattgccg gagacctttg tttcaatccg ctgaaagacc gtttggtgaa tcatgacggt
    10861 gaaaaggtga aactcagtga acctcaaggt gacgaacttc catcagccgg atttgtagcc
    10921 ggtaatcagg gttatcaggc tcccggcggt gagaaaaacg agatcagagt ggctcccgat
    10981 tctcaacggt tgcagttgtt gactcctttc cccgcgtggg atggcaatga ttttctcaat
    11041 atgccgctgc ttatcaaagc acagggtaag tgtacgacag accatatttc gatggcgggt
    11101 ccctggcttc ggttccgggg gcatctggag aatatatctg ataatatgct gatgggagcg
    11161 gtgaatgctt tcaatggcga aacgaataag gtatggaatc gtttgaccaa tacctatgaa
    11221 actgtttcgg gtacggctaa acagtataag gcggacggta tctcttccat cgttgtggcc
    11281 gaagaaaatt acggtgaagg ttccagtcgt gagcatgccg ctatggaacc gcgtttcctt
    11341 catgtaaagg tgatcctggc taagagtttt gctcgtatcc atgagactaa tctgaaaaag
    11401 caaggtatgc tggctgttac atttgcagac aaggccgatt atgaccggat tcgtgagcac
    11461 gatttgatct cggtagtcgg attgaaagag ttttcacccg gacgcaatct ggaggtgata
    11521 ttgcaccacg aagatggtac ggaagaacgg tttgctgtac aacatactta caatgaacaa
    11581 cagatcggct ggttccgtgc cggttctgct ttgaatgcaa aatagccttc aggaggcttt
    11641 cagcggcccg cttttaggtt tgaaaatcaa taggacttag gtttaaaacc aacgggtctt
    11701 tagtttaaaa ggtaaggagt gttggttcta aaccaacgaa cctttacttc ggaacacgat
    11761 tggaggagta tataaaaaga taaatagatg agtaaaatta ccaaacagca aaatggagta
    11821 ttgtcagtgc cggatgtacc gacaatacct tttataacgg gagatggagt aggagcggaa
    11881 ataactccgg ccatgcaggc gatagtagat gcggcggtag acatgtcgta tggtggtgcc
    11941 cggcgtatcg aatggaaaga agtactggcc ggtgaacgtg ctttccgggc taccggttcg
    12001 tggttgccgg acgaaacgat ggaggttttc aaggagtatc tgataggcat caaaggaccg
    12061 ttgactactc cggtaggagg aggaatacgt tcgttgaacg tggctttgcg ccagacactc
    12121 gatttatatg tctgcctgcg tccggtacgt tggttccgcg gagtggtgtc tccggtcaaa
    12181 gagcccgaaa aggtgaatat gtacatcttt cgtgagaata cggaagatat ctatgccggt
    12241 atcgaatggg aagcaggcac tccggaagct aagaagttct accggttctt gcacgaagag
    12301 atgggagtca gtaaagtacg tttccccgaa acctcttctt ttggtgtgaa accggtttcg
    12361 cgtgagggga cggagcgtct ggtacgcgct gcctgccgtt atgcgttgca gcatgaattg
    12421 ccctcggtca ccttggtgca caaaggtaat atcatgaaat tcacagaagg aggttttaag
    12481 aagtgggggt acgaattggc tgagcgggag tttgcagatg ctcttgcctc aggtaaactg
    12541 gtgatcaaag actgtatagc cgatgccttt ttgcagaaca ctcttttgat tcctgaagaa
    12601 tattcggtca ttgccactct gaatctgaac ggagactata tttccgacca actggctgcg
    12661 atggtaggtg gcattggtat tgcaccggga gccaatatca attatgattc cggacacgcc
    12721 atctttgagg ccactcatgg gacagccccc aatattgccg gaaagaatgt ggtgaatccc
    12781 tgttcactga tactttcggc cgttatgatg cttgaatata taggctggca agaacccgcc
    12841 gatcttatcg tcgaggcgct tgaagccagt tttgccgagg ggaaagccac taatgacctg
    12901 gcacgtttca tgcacaaagg ccagccgctc tctacttcgg aatttacccg ggaaatcatt
    12961 aaccgaatta aaaattaata ccttcaggac atgaaaaaag aatatttgat ttataaactc
    13021 tccgaggcaa tgaaggattg tacccggatt gataacgaat tgtttccaaa atttgacgtt
    13081 aaacgggggc ttcgcaatga agacggtaca ggtgtattgg tcggattgac caagattggt
    13141 aatgtcgtag gatacgaacg aatccccgga ggtggtctga agccgatccc gggaaagttg
    13201 ttttaccgtg gatatgacct ggaagattta gcccacgcca ttttaaaaga aaaacgtttc
    13261 ggatttgaag aggtggccta cctgctgtta tccggcagtt tgcccgataa ggaagaactg
    13321 gcttcgtttc gcgagctgat caatgataat atgcctttgg agcagaagac caagatgaat
    13381 atcattgaac ttgaaggaaa caatattatg aatattctag cgcgcagcgt actcgagatg
    13441 tatcgtttcg atcctaatcc ggatgatact tcacgtgaca acctaatgcg tcagagcatc
    13501 gatctgatct cgaaattccc gaccattatt gcttatgctt ttaacatgtt gcgtcatgcc
    13561 accttcgggc gttcgttaca cattcgtcat ccgcaggaga atctgtcgat tgccgaaaac
    13621 tttctctata tgctgaaacg cgattatacc gagctggatg cgcgtacact cgaccttttg
    13681 ttggtgcttc aggcagagca cggaggaggt aacaactcta cgtttactgt ccgggtaact
    13741 tcgtctaccg gtacagatac atactcggcc attgccgcag gcatcgggtc gctgaaaggc
    13801 ccgcttcacg gaggagccaa tattcaggta gccgatatgt tccatcattt acaggaaaat
    13861 attcaggact ggaccaatgt agacgaaatc gatacttact ttacccgtat gttgaataag
    13921 gaggtttaca ataagaccgg attgatatat ggcatcgggc atgccgtata taccatttcc
    13981 gatccgcgag ctgtgttgct gaaggaactt gcacgtgact tggcacacga gaaaggtcgt
    14041 gaacgggagt ttgcttttct tgaacttttg gaagaacgtg ctatcgctac tttcggtaag
    14101 attaagaata atgggaaaac agtatccagc aacgttgatt tttattccgg ttttgtttat
    14161 gagatgattg gcctgccgca ggaaatctat acccccttgt ttgccatggc gcgtatcgtg
    14221 ggttggtgtg cccatcgcaa cgaagagttg aattttgaag gtaaacgtat cattcgtccg
    14281 gcttataaaa atgtgttgga agaagaacaa tatgtaccgt taaagaaacg gtaaaagaga
    14341 agcttgaagt cagaagttca ccacagattt acagattgca cagaccggca ccggcattga
    14401 ttgattatct gtcagttcta tgtttgtacc gtctgccaat ctgtggtaga acagactttt
    14461 gtgatacgct tgctttattt tcgtaaacta tttgtccctt taaagttttt cttttaactt
    14521 tgtccttgta taaaatcttg gatatgagta tagaaagctt taatctgctt cttttagtaa
    14581 tgggcctgat ggctttggtc gtattcatag ccctttattt tgtcagggcg ggatatggca
    14641 tgtttcgcag ccgttcctgg ggaatctcgg tgaataataa gatagcctgg attctgatgg
    14701 aagctcctgt ctttctggtt atgggatggt tgtggtggca ttccgaccga cgttttttac
    14761 ctgtcgaact cactttcttt ctttttttcc aactacatta cttccaaagg gcttttgttt
    14821 ttcctttcct gatgaaagga aagagcaaga tgccggtact cattcttttg atgggagtga
    14881 tctttaatat tctcaacgga ctgatgcagg gagaatggat attctatctt gctccctcgg
    14941 actattatac acccggatgg ttgctgactc cttgcttttg gata
//
