LOCUS       c00392_gnlPro..        12589 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GJPBCNGJ_392.
ACCESSION   c00392_gnlPro..
VERSION     c00392_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 08:18:22
            Original ID  :: gnl|Prokka|GJPBCNGJ_392
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12589
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12589
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7595:12589]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7596..12589
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..12589
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12589
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(2..391)
                     /locus_tag="ctg392_1"
                     /transl_table=11
                     /translation="MKKSVKHKFQYLLFFLLSMPAFIFASAQDIRVNIDFTKASLGSVL
                     NEIGRQTSLSIVYNTGDVNPTQPVSIKASNENITTVMNRLLRGTGLSYSIMNKHLILST
                     TDKNHSIQQEKVTVTGNISDAKGEPL"
     CDS             complement(702..1712)
                     /locus_tag="ctg392_2"
                     /transl_table=11
                     /translation="MDETKLLNYLKGESDAEECLEVEAWYHASAEHKKQLDQLYYMLFV
                     GERKVAMDGVDTENSLSVLKDRIKHKESEKKSVHRIRVSKWKRYAMPLAAFLCGLLVSV
                     GALYWISSGKSAGYIFATESGQRAQAVLPDGTKVWLNASTQIVYKPSFWKRERQVDLSG
                     EAYFEVSRNKTKPFVVNSNDVRTCVLGTKFNVRARPSEEKVVTTLLKGSVKVQLPGQSE
                     EEGILLKPGQMLSVDTRTMQPMLTEANRPGDVLLWINGKLKFEQATLQEIVQCLEKHFD
                     VHFIISDAQLQKDRFTCTFSTDDDIRQILSILALTKRFDYKCEDNNIILTPKTNR"
     CDS             1878..2477
                     /locus_tag="ctg392_3"
                     /transl_table=11
                     /translation="MAQTLTNLNINDNNAVISALREGDEEVFDHIYRYYFRGLCAFCSQ
                     YVTLSESEEIVQDTMMWLWENRKTLIPELTLKTLLFTIVKNKALNKISHFEIKRKVHQE
                     IAEKYETEFSSPDFYLENELFRLYEEALRKLPAEFRQAYEMNRSLQMTHKEIAEKLNVS
                     PQTINYRIGQALKILRSELKDYLPLIMLFLFLQGHK"
     CDS             complement(2454..4469)
                     /locus_tag="ctg392_4"
                     /transl_table=11
                     /translation="MKQILHILLIALMLMGFYSCVPKTELASPDGHIKVAFTADTDGKM
                     MYRVTVNDTFLLDNSPLGFEAKDGIDLNRGFRVVSTVFTDKDEIWTQPWGENKTNRNHY
                     NEMAVLLKNAANVELTLRFRAFDDGVAFRYEYEVPGVDSLLITDELTAFRFHEDGTSWS
                     IPASFETYELLYSKQKISEVENANTPFTFKTSGGVYGSIHEAALYDFPEMTLKKDGENT
                     LKSELASWPDGIKARKENRFTTAWRTIQIAPQAVGLINSSLILNLNEPCKLDTTDWIKP
                     MKYVGVWWGMHLGVETWKMDDRHGATTANAKKYIDFAHANSIEGVLFEGWNEGWESWGG
                     MQSFDFTKPYADFDMDEITRYAREKNVQIIGHHETGGNIPNYERQMEKAIKWYTDKGIH
                     ILKTGYAGAFPDGHSHHGQYGVNHYQKVVETAARYRMTLDAHEPIKDTGIRRTWPNMMT
                     REGARGMEWNAWSEGNPPSHHEMLPFTRLLGGPMDYTPGTFDILFTQTKDSPKRQKWND
                     QDKGNSRVNTTLAKQLANWVILYSPLQMASDMIEHYEGHPAFQFFRDFDPDCDESRALA
                     GEPGEFVAVVRKAKQNYFLGASTNEEPRVLPVSLDFLEKGKIYKAIIYADGEKADWKTN
                     PTEYQITEQEVTADDTLNIRMAAGGGQAISFMPLQK"
     CDS             complement(4492..5349)
                     /locus_tag="ctg392_5"
                     /transl_table=11
                     /translation="MNKICFFIGVFITLLLAGCSSNPITHVRVATFNIRYDNLGDSLNS
                     WKYRKEKVCEFIREKHPDVLGMQEVLNHQLKDLLSGLPDYAYVGVGREDGKTQGEYAPV
                     FYRKDKYDLLDSNTFWLSEHPDSIGKLGWDAACTRVATWAKLKDKTTGKEFLMLNTHFD
                     HVGTEARRNSALLIIDKIKEIAGTHPAMMTGDFNVSEEWEAYKTITSNEFVLKDAWKIA
                     GKQSGENYTFHDFGRVPVAEREKIDFIFVTPQIKVADTEIISSAITDSTYLSDHNAHLA
                     DLEF"
     CDS             complement(5420..6514)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 60.6; E-value:
                     3.5e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg392_6"
                     /sec_met_domain="AMP-binding (E-value: 6.9e-20, bitscore:
                     60.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFNREEQHLMLEGSVLSKEDVKRLVACHTEEASGFLYELYRFLE
                     EWFSDSPYLTVKTSGSTGTPKLLKVRKEQMMQSARLTCEFLGLRQGDSVLLCMPLQYIA
                     GKMVVVRALVAGLNLVIRTPSGHPMADVDIPLRFVAMVPLQVYNTLQVPAEKERLCRTD
                     ILIIGGGAIDAGLEAEIRQLPVKVYSTYGMTETLSHIALRQLNGPDASMLYRPFPSVRL
                     SLSSEHTLVIDAPLVCDTTLVTNDVAEIYSDGSFSILGRKDNTINTGGIKVQAEQIEEI
                     LRPWMRVPFAITSVPDARLGEAVVLLVEKGADAELPETKMKELLSKYQLPKMILSVGAI
                     PLTETGKINRAACRQLALTYRTDR"
     CDS             complement(6528..7547)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg392_7"
                     /sec_met_domain="MR_MLE_C (E-value: 1.3e-30, bitscore:
                     96.3, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTINIIPRVLHFKQPAGTSRGSYTTRNVWYIHLSSIECPGRVGV
                     GECAPLPKLSCDDLPDYEQVLRSACQRLEQTGELDIESLRGYPSILFGLETALRHYETQ
                     SWALWDTPFSRGEAGIPINGLIWMGSFDRMLQQIEVKMQAGYRCIKLKIGAINFEEELA
                     LLRHIRAHYSAREIELRVDANGAFSPADAMDKLNRLAELDLHSIEQPIRAGQWEEMARL
                     AAESPLPIALDEELIGCNALERKRELLAAIHPRYIILKPSLHGGISGGNEWIAEAEKQH
                     IGWWITSALESNIGLNAIAQWCATFRNPLPQGLGTGLLFTDNVEMSLEIRKDCLWFCK"
     CDS             complement(7596..8420)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg392_8"
                     /sec_met_domain="ECH_1 (E-value: 2.8e-83, bitscore: 268.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTPIKEYEDILFDYYNGIARITINRERYRNAFTPTTTGE
                     MSDAMRICREEPDINVVVLTGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMQLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPDFKQYPKFP"
     CDS             complement(8442..9446)
                     /locus_tag="ctg392_9"
                     /transl_table=11
                     /translation="MMTKHKMNLFCGMLLLSASLFVEKAQAMFPERYVSEESAARADTI
                     NFRLASAGEAKRLIAAKDSYTANWSPFDIAARLENPEGKREDLVSLAVREVREWTAEEA
                     QQIEQIRKNLNDTIRKYGYRIPFPKEIVLVKTTMKDEGGAGGYTRSNWIALTDATFQRG
                     TEASHTRLLVHETFHILTRLNPGFKKKLYRAIDFNILPKEIEFPEDIRKSRISNPDVSR
                     CDSYATFTIDGKPQNCTMIIYTNRPYTTGKFYQYINVGLIPLDESFKPLRESGKTVIYP
                     LQKATDFFDKVGRNTGYVIDPEEVLADNFAIALLNTPNVHTPELQKKVQELLK"
     CDS             complement(9448..11115)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg392_10"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.4e-08, bitscore:
                     23.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLRAHGVTKVVLCPGSRNAPIVHTLAGHPDFT
                     CYSVTDERSAGFFAIGLALQGGTPAAVCCTSGTALLNLHPAIAEAYYQKVSLVVISADR
                     PAAWINQMDGQTLPQPGVFRSLVKKSVDLPEIHTDEDEWYCNRLLNEALLELNHHGKGP
                     VHINVPVSEPLFQFTAESLPEVRVITRYQGLNVYDRDYDGLIDRLNKYNRRMMIVGQMN
                     LIYLFEKKYSKMLYKQFAWFTEHLGNQTVPGIPIRNFDAALYAMSPEMQEKMIPELVIT
                     YGGHIVSKRMKKYLRQHPPKEHWHVSPDGEVIDLFQGALTTIIEMDPFEFMEKIAFLLD
                     NRTPEYPRQWENFCKELPRPELPYSEMSAIGSLIQALPASCALHLANSSAVRYAQLYSL
                     PDTVEVCCNRGTSGIEGSLSTAIGYAAASKKLNFVVIGDLSFFYDMNALWNNHFGSNLR
                     ILLLNNGGGEIFHTLPGLEMSGTSHRFVTAVHKTSAKGWAEERGFLYQEVQDEKQLDEA
                     MKTFTQPELLTQPVIMEVFTNKNKDARILKDYYHQLKN"
     CDS             complement(11136..12242)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg392_11"
                     /sec_met_domain="Chorismate_bind (E-value: 1.2e-54,
                     bitscore: 175.2, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLEETNNCEIIDELIRQGRSFAMYRNPGEEEPHFLMQTCGEVHL
                     IRKMEDLNGRTGFVIAPFRVTPQCPIILIRPDCHEIPSCAGNLHTPAQGDDAASYGQQL
                     RSDRSLGAKKAYEACFDVFIRALRERTFDKLVLSRRMTVRREPGFSPAAAFYRACRRYI
                     YSYVYLCYTPQTGVWMGSTPEIILSGEKGEWNTVALAGTQSLQNGELPQQWDEKNREEQ
                     EYVAAYIRKQLRSLGISPTEKGPYPAFAGALSHLKTDFHFSLNDSQRLGDLLKLLHPTP
                     AVCGLPKEEAYRFILDNEGYDRSYYSGFIGWLRPEGRTDLYVNLRCMNVKEDSLTLYAG
                     GGLLASSELDDEFQETEKKMQTMQNLNS"
     CDS             complement(12239..12589)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg392_12"
                     /sec_met_domain="HBT (E-value: 2e-19, bitscore: 59.6,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLG
                     SMILCQPDEIVVGMQVSGNHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDVFTSTDKLVS
                     SIRVVNSILKKR"
ORIGIN
        1 tcagtggttc gcctttggca tccgaaatat ttcctgtaac cgtaactttc tcctgttgaa
       61 tcgaatggtt cttatcagtg gtcgaaagaa taagatgttt gttcataata gaataggaaa
      121 gtcccgttcc acgaagcaga cggttcatga ccgtcgtgat attttcgtta gaagccttga
      181 tagaaacagg ttgagtgggg ttaacatccc cggtgttata cacaatagat aatgaggttt
      241 gacgtcctat ttcattcagg acactgccca aagaggcttt ggtaaagtcg atattcaccc
      301 gtatatcttg cgctgaagca aagataaaag caggcatcga caatagaaaa aatagcaagt
      361 actgaaactt gtgtttcact gatttcttca tcttgttctt ttttttaatt agaaaatgtt
      421 tttaggtaaa attgaaaggt ttagcataaa ggatcgctaa tacatgttaa ggttggtttt
      481 aaattaaggg tcattattca tcactacaga tttttaggtt aactatatct cttttctgtt
      541 aatagtacat ttcaacttat aaacatacta aatcaagaag cggatttttt cgaaaaaaga
      601 ataaaaaaag aataagaata cagatcagaa gataaaaaaa gggaactatt tctttacaga
      661 aacagccccc tcttcgtgat ttaggttata aaatattttt gttatctatt cgtcttagga
      721 gtcaatatta tattgttatc ctcacattta taatcgaaac gtttggtaag agcgagtata
      781 gaaagaattt gtcttatatc atcgtccgta ctaaaagtac aggtaaaacg gtccttttgc
      841 agttgtgcat ccgaaataat gaaatgaaca tcaaaatgtt tttcaagaca ctgcactatt
      901 tcctgaagtg tggcctgttc gaatttcagt tttccgttaa tccatagcaa tacatctccc
      961 ggacggttgg cttctgtaag catgggttgc atcgtacggg tatccacact cagcatctgt
     1021 cccggcttca acaaaatacc ttcctcttca gactgccccg gcaattggac ttttactgat
     1081 cccttcaata aagtggtcac caccttttct tcggacggac gtgcccggac attgaatttt
     1141 gtaccgagca cgcaagtcct gacatcatta ctattaacaa caaagggttt tgtcttatta
     1201 cgtgatacct caaaataagc ctcaccactc aagtcgacct gtctttcccg cttccagaaa
     1261 gaaggcttat agacgatctg tgttgaagca ttcaaccata ctttcgttcc atccggtaaa
     1321 actgcctgtg cccgctgccc tgattcggta gcaaaaatat atcctgccga ctttccggag
     1381 gaaatccagt atagggcacc gacagacacc aacagaccgc acaggaaagc tgccaaaggc
     1441 atcgcgtaac gtttccattt tgatacacgt attctatgca ctgatttttt ctctgactct
     1501 ttgtgcttta tccggtcctt caaaacgctt agtgaatttt cggtgtccac accatccatt
     1561 gccaccttac gttcaccgac aaaaagcata taataaagtt ggtccagttg ttttttgtgt
     1621 tctgcagaag catgatacca tgcctccact tccagacact cttcggcatc tgattctcct
     1681 ttcagatagt tcagtagttt tgtttcatcc attgttttaa ccaaatcttt aatacctata
     1741 tcatacactg ttatgtataa tacagttcag aaaacaaagt tactaaataa aacacaaact
     1801 tttttttctt cagaaaatca ttttgtaggt agcaaaaatt tagctacgtt tgttcgctaa
     1861 taacaatgga gagaagaatg gcacagactc tgactaacct aaacataaat gataataatg
     1921 ccgttatatc agccctgcga gaaggggatg aagaggtgtt tgatcatatc taccgttact
     1981 attttcgtgg attatgcgcc ttttgctctc aatatgtcac tctgagcgaa tcggaagaaa
     2041 tcgtgcagga tactatgatg tggctatggg aaaacagaaa aacccttata ccggaactta
     2101 ctttaaagac tcttctcttt actatcgtca agaacaaagc gcttaataaa atctctcatt
     2161 ttgaaataaa acgcaaggtg catcaggaaa ttgcggaaaa atatgaaacg gagttctctt
     2221 cacctgactt ttacctagaa aacgaactat tcagattgta cgaagaggct ttaagaaaac
     2281 taccggccga atttcgccag gcatacgaaa tgaatcgaag tcttcaaatg actcataaag
     2341 aaattgcgga gaaactgaac gtctctccgc aaacaatcaa ttatcgcata gggcaagccc
     2401 tgaaaatatt acggtccgaa ctaaaggatt atctcccgct gatcatgttg tttttatttc
     2461 tgcaagggca taaatgaaat agcttgtccg ccaccggctg ccatacggat attcaacgta
     2521 tcgtctgcag tcacctcctg ttccgtaatc tgatactctg tcggattggt tttccaatca
     2581 gctttctcac catcagcata gatgattgct ttataaatct tccccttctc taaaaaatca
     2641 agactgacag gcaagacccg cggttcttca ttcgtagagg cacccaggaa ataattctgt
     2701 ttagccttcc gtaccactgc tacaaactct cccggctcac cggccaatgc cctcgattcg
     2761 tcacaatcag gatcgaaatc acggaagaac tggaaggcag gatgcccttc atagtgctcg
     2821 atcatatcag atgccatttg taacggagaa tataaaatca cccaattagc caactgcttg
     2881 gccaatgttg tattgacgcg actattgccc ttatcctgat cattccactt ctgacgttta
     2941 ggagaatctt tcgtctgtgt aaacaaaata tcaaaagtac ccggagtata gtccatcgga
     3001 ccacccaata agcgggtaaa cggcaacatt tcatgatgtg aaggaggatt accctcgctc
     3061 caggcattcc actccatacc gcgggcgcct tcacgtgtca tcatattggg ccaggtacgt
     3121 cgtataccgg tatctttgat aggttcgtgc gcatcaagag tcatacgata acgggcagcc
     3181 gtctcaacca ctttttgata atggttcact ccatattgtc catgatgtga atgtccgtca
     3241 ggaaaagcac cggcataacc tgttttcaga atatgaatgc ccttatcggt ataccacttg
     3301 attgccttct ccatctggcg ctcgtagttg ggaatgtttc caccggtttc atgatgtccg
     3361 atgatctgaa cattcttttc acgtgcataa cgagttattt catccatatc aaagtcggca
     3421 taaggtttag taaagtcaaa actctgcata cctccccaac tttcccatcc ttcgttccac
     3481 ccctcaaaca acacaccttc gatgctattg gcatgagcaa aatcaatgta tttcttggca
     3541 ttggcggttg tagcgccatg ccgatcgtcc atcttccagg tttccactcc cagatgcatc
     3601 ccccaccaga caccgacata tttcatcggc ttgatccagt cggtggtatc cagtttacaa
     3661 ggttcattca ggttaaggat caacgacgaa ttaatcagtc cgacagcttg cggagcgatc
     3721 tgaatggtac gccatgcagt ggtaaaacga ttctctttac gagctttaat tccatcaggc
     3781 catgaggcaa gttcggattt cagagtattt tcaccatcct tcttcaaagt catttccgga
     3841 aaatcataaa gagcagcttc atgaatgctg ccatacaccc ctccggatgt tttgaaagtg
     3901 aaaggagtat tggcattctc cacttcactg atcttctgtt tcgagtacag caattcataa
     3961 gtctcgaaac tggcaggaat agaccaagag gtcccgtctt catgaaagcg gaaagcagtc
     4021 agttcatcgg tgatcaacaa agagtcgaca ccgggcacct catactcgta acgaaaggct
     4081 acaccatcat caaatgcacg aaaacgaaga gtcaattcca cattagcggc atttttcaga
     4141 agaaccgcca tttcattata atgattccgg ttcgttttat tctctcccca aggctgcgtc
     4201 cagatctcgt ctttatcggt aaagacagtg ctcaccacac gaaatccccg attaagatcg
     4261 attccgtctt tcgcttcgaa accgagcgga gagttatcca ataaaaaggt atcgttgaca
     4321 gtcacccgat acatcatctt tccatcggta tccgcagtaa aagccacttt gatatgtccg
     4381 tccggagagg ctaattccgt cttcggaaca caactataaa agcccatcag catcaaggcg
     4441 atgagtaata tatgcaaaat ctgtttcatg gttacaattc atttatacgg tttagaattc
     4501 caaatcagcc agatgtgcat tatgatcgga caaataggtg gaatctgtaa tcgcagaaga
     4561 aataatctct gtatctgcca ccttgatttg cggagttacg aaaatgaaat cgatcttttc
     4621 ccgttcggcc acaggtactc ttccgaaatc atggaaagta tagttctcac cggactgttt
     4681 cccggctatc ttccatgcat ctttcaagac aaactcattg gatgtgatcg ttttgtaagc
     4741 ttcccactct tcagaaacat taaagtctcc ggtcatcata gcaggatgtg taccggctat
     4801 ttcttttatc ttatcaataa taagcagggc actgttacga cgagcttccg taccaacgtg
     4861 gtcaaaatgg gtgtttaaca tcagaaactc ttttccggta gttttatcct ttaatttagc
     4921 ccaagtagcc acgcgggtac acgcggcatc ccaaccaagt ttgccgatac tatccggatg
     4981 ttcggaaagc cagaatgtat tactgtctaa caaatcatat ttatctttcc gatagaatac
     5041 aggagcatat tccccctgag tctttccatc ctcgcgtccc acacctacat aggcataatc
     5101 gggcaggccg gacaacaggt ctttcaactg atgattcagt acttcctgca ttcccagcac
     5161 atcgggatgt ttctcacgga taaattcaca gaccttctct ttacgatact tccaggaatt
     5221 caaactgtcg cccagattat catagcggat attaaaggtc gccacacgaa catgggtaat
     5281 cggattagaa ctacaacccg ccaaaagcag ggtaataaaa actccgataa aaaagcaaat
     5341 cttattcatt agtttatatg tgttggttat taaatttaaa gctatttcgt atatgataca
     5401 actaaagaag aaaaaacact tagcgatctg tccgataagt gagggcaagt tgccggcaag
     5461 cggcacgatt gatctttccc gtttccgtca agggtatagc cccgactgac aaaatcatct
     5521 tgggtaactg atatttagac agaagctcct tcatctttgt ttccggtaac tctgcatctg
     5581 cccccttctc taccaaaagc acaaccgcct ctcctaatct ggcatcgggt acagaagtga
     5641 ttgcaaaagg aactctcatc cagggacgaa gtatctcttc tatctgctct gcctgtactt
     5701 tgatacctcc ggtattgatg gtattatcct tcctgcccaa aatagagaag ctgccatcgg
     5761 aatagatttc cgcaacatca tttgtcacca aagtggtatc acaaaccaat ggagcatcga
     5821 tcaccaatgt atgttcggac gaaagagaaa gccgcaccga aggaaaaggc cggtacaaca
     5881 tactcgcatc cggtccgttc aactgtctta aagcaatatg tgaaagggtt tctgtcatgc
     5941 catacgtaga ataaacctta accggtaatt gccgtatttc agcttccaac cctgcatcta
     6001 ttgcccctcc gcctataata agaatatcgg tccggcagag cctctctttt tctgccggta
     6061 cctgcagtgt gttgtaaacc tgcaacggca ccatagcgac aaagcgaagc ggtatgtcca
     6121 cgtccgccat cggatgcccg gaaggagtcc ggataaccag attcaaccct gccaccaatg
     6181 cccggaccac caccatcttc ccggcaatat attgcaaagg catacacaac aatacgctat
     6241 ctccttgtcg aagtcccaga aactcacaag tcagccgggc actttgcatc atctgctcct
     6301 tacggacctt cagcagtttg ggagtcccag tagaaccgga agttttcact gtcagataag
     6361 gagaatcact gaaccactct tccagaaacc ggtaaagttc gtacaaaaat cccgatgcct
     6421 cctccgtgtg acaagccacc agccttttca cgtcctcctt ggaaagcaca ctgccttcca
     6481 acattaggtg ttgttcttct ctattaaata tcatgtgccg actcctctta tttgcaaaac
     6541 cataaacaat cttttcgaat ctcgagggac atctcgacat tgtccgtaaa cagtagcccg
     6601 gtacctaatc cttgtggtaa cggattccgg aaagtcgcac accattgggc tatggcattc
     6661 agaccgatat tcgactccag cgcagatgtg atccaccatc cgatatgttg cttttccgct
     6721 tctgcaatcc attcgttgcc accactgatc ccgccatgca gagatggttt cagtatgata
     6781 taccgggggt ggatagccgc cagcaattcc cgttttcttt caagggcatt gcaacctatc
     6841 agttcttcgt ccaaagcaat aggaagcggg gactcagccg ccagacgggc catttcctcc
     6901 cactgcccgg cccggatagg ctgttctatg gaatgtaggt ccaattcggc caaccgattc
     6961 agtttatcca tagcatcggc aggtgagaaa gctccattgg catccactct caactctatt
     7021 tctctggcgg aatagtgagc acggatatgt ctcaacaggg ctaattcttc ttcaaagttt
     7081 atcgcaccga tttttagttt gatacagcga tatcccgcct gcatcttgac ttcgatctgt
     7141 tgcagcattc tgtcaaaact tcccatccag ataagtccgt taataggtat accggcttct
     7201 ccgcgcgaaa aaggagtatc ccataatgcc cagctctgtg tttcgtaatg gcgcagtgct
     7261 gtctcgagtc cgaacagaat agaaggatac ccacgtaaag attctatatc cagttctccc
     7321 gtttgttcca gtcgctgaca ggcactccga agcacctgtt cataatccgg caagtcatca
     7381 caactcagtt tgggtaacgg agcacactct cctactccga cacgtcccgg acactctatg
     7441 gaagaaagat ggatatacca gacattccgg gtagtataag aaccacgcga agttcccgca
     7501 ggttgcttga aatgaagaac acgtggaata atgttgattg tatacataaa aatgatataa
     7561 agaaaaggcc tcccatcaag aaggcctctg tctgcttatg gaaatttagg atattgttta
     7621 aagtccggtt tacgcttctc cagaaaagca ttcttgcctt cctgtgcttc atcggtaagg
     7681 taataaagca gagtggcatc acctgccagt tcctgaatac cggcttgacc gtcgagttcg
     7741 gcattcagac cggctttaat catgcggagt gccaacggac taagctgcat catctcctcc
     7801 gcccactgaa catactcgtc ttccagttta tccagcggta ccactttatt gaccagcccc
     7861 atatccagag cctcctgcgc attatacttg cgacaaagga accagatctc acgggccttc
     7921 ttctgtccca caacgcgggc aagataagat gatccgaagc cggcatcgaa actacctaca
     7981 cgaggacctg tctgtccgaa gatcgcattt tcggaagcaa tagagagatc gcatacgaca
     8041 tgcaacacgt gtccgcctcc gatggcaaat ccgttaacgg cagcaataac cggtttcgga
     8101 atcgaacgga tttgtttttg cacatccagt acactcaggc ggggcactcc gtctttaccg
     8161 atgtatccgc cacggccctt tacgttctgg tcgcctcccg aacagaaggc cttatcgcct
     8221 gcaccggtca ataccacaac attgatatcg ggctcttcac gacagatgcg catcgcatcg
     8281 ctcatttcgc ctgttgtagt aggggtgaaa gcattccggt aacgttcgcg attgatcgta
     8341 atacgggcaa tgccgttata gtaatcaaac agaatatctt cgtattcttt aataggagtc
     8401 cattctcttt tagtttccat ttctatttat tttgatgatt attatttcag taattcctgt
     8461 actttctttt gcagttcggg tgtatgtaca ttgggcgtgt tcaataaagc aattgcaaaa
     8521 ttatccgcca gcacctcttc cggatctatg acatatccgg tgttccgccc tactttatca
     8581 aagaagtcgg tcgctttctg taatggataa ataactgtct tcccactctc ccggagaggc
     8641 ttgaacgact cgtccaacgg aatcagcccc acattgatat actgatagaa cttacccgtg
     8701 gtatagggtc tgttggtata gataatcata gtgcagttct gtggcttacc gtcaatagta
     8761 aaagtcgcat aactatcgca acgactgaca tcgggattgg agatacggct tttccgtata
     8821 tcttcgggga actcaatctc tttgggcagg atgttgaagt cgatagctct gtacagtttc
     8881 tttttgaatc cgggattgag acgtgtcagg atgtggaaag tttcatgcac cagcaggcgt
     8941 gtgtgagaag cttcggtccc ccgctgaaaa gtagcgtccg tcaatgcgat ccagttactg
     9001 cgtgtgtatc ctcccgcccc tccttcgtct ttcattgttg tctttaccag cacaatctct
     9061 ttcggaaatg gaatccgata gccgtattta cgaatcgtat cattcaggtt cttcctgatc
     9121 tgctcgatct gctgcgcttc ttccgctgtc cattcacgca cttcacgaac ggccaggctg
     9181 acgaggtctt ctcttttgcc ttcaggattt tcaagtcggg cagcgatgtc aaacggactc
     9241 caattagccg tataagaatc tttggccgct atcaggcgtt ttgcttctcc ggcagaagcc
     9301 aaccgaaaat tgattgtatc tgccctggct gccgattcct ccgatacgta tctctcggga
     9361 aacatggctt gagctttctc cacaaacagg gaagctgaca aaagtagcat cccacaaaat
     9421 aggttcatct tgtgcttagt catcatatta gttttttagt tggtgatagt agtctttcaa
     9481 tatccgtgca tctttatttt tattggtgaa aacctccata atgacaggtt gagtcagtaa
     9541 ctcgggttga gtgaaagttt tcatggcttc gtccaactgt ttttcatcct gcacttcctg
     9601 atagaggaat ccccgttctt cggcccatcc cttggcagac gtcttatgca cggcagtcac
     9661 aaagcgatgg gaagtaccgg acatttcaag tcccggcaaa gtatgaaaaa tctcccctcc
     9721 cccattattc aaaagcagaa tacggaggtt acttccaaaa tgattgttcc acagggcatt
     9781 catatcatag aaaaagctca gatcaccaat gaccacaaag ttcaacttct tcgaagcggc
     9841 agcataaccg atcgctgtgg aaagggaacc ttcaatgccg ctcgtacccc ggttgcaaca
     9901 aacctctacc gtatcgggaa gcgaataaag ctgggcataa cgcacggcgg aactattggc
     9961 cagatgcaaa gcacacgaag caggcaacgc ctgaatgagt gatccgatag cagacatttc
    10021 ggaataaggc aactccggtc ggggaagctc cttgcagaag ttctcccatt gccggggata
    10081 ttccggtgta cggttatcca gcagaaaagc tatcttctcc ataaattcaa atgggtccat
    10141 ctcgataatc gtagtcaatg ccccttggaa cagatcgatc acttcaccat ccggcgacac
    10201 atgccaatgc tctttgggcg gatgctggcg aagatacttt ttcattcgtt tagagacgat
    10261 atgccccccg taagtgatca ccaattcggg aatcatcttc tcttgcatct cgggtgacat
    10321 ggcatagagg gctgcatcga agttccggat cgggatgccc ggaacggtct gattgcctaa
    10381 atgctccgtg aaccaggcaa actgcttgta gagcatcttt gaatatttct tttcgaacag
    10441 ataaatcagg ttcatttggc cgacgatcat catacggcgg ttgtatttat tgaggcggtc
    10501 gatcaagccg tcatagtcgc gatcataaac attcagtcct tgataacgtg tgatgacacg
    10561 tacttcggga agtgactctg ccgtaaactg gaacaggggt tcggaaaccg gcacgttgat
    10621 gtgcacagga cctttaccat gatgattcag ttcaagcaat gcttcgttca gcaagcggtt
    10681 gcagtaccat tcatcctcgt ccgtatgtat ttcgggcaga tcgacagact tcttcaccaa
    10741 tgaccggaaa acacccggct gaggtaaagt ctgtccgtcc atctggttga tccaggcggc
    10801 aggacgatcg gcggaaataa ctactaaaga tactttctgg tagtaggcct ctgctatggc
    10861 aggatgcaaa ttcaacaaag ccgtgcccga tgtgcaacaa acagcggcag gagttccgcc
    10921 ctgtaaagca agcccgatag caaaaaagcc ggcactccgc tcgtctgtta ccgagtaaca
    10981 agtgaagtcg ggatgtccgg caagtgtatg tacaatcggt gcattccggc ttccgggaca
    11041 taaaacgact ttcgtcaccc catgtgcacg gagcaacgct accaactgca atatgttttt
    11101 cttatctgaa tacatcgctt tatatattat tttatttagg agttcaagtt ctgcatggtc
    11161 tgcatcttct tttccgtctc ctgaaactca tcatccaact cggaagaggc cagcaggccg
    11221 cctccggcat acaatgtcaa cgaatcttct ttcacattca tacagcgtaa gttgacatac
    11281 aggtccgttc tcccttccgg cctcaaccag cctataaatc cggaataata gctgcggtca
    11341 tagccttcat tgtcaaggat aaaccgataa gcttcttctt ttggcaatcc gcatacggca
    11401 ggagtgggat gcaacagctt caataaatct cccaacctct gactgtcgtt cagcgagaag
    11461 tggaaatccg ttttcaggtg agacaatgcc ccggcaaaag ccggataagg tcctttctct
    11521 gtcggagaaa tccccaacga gcggagttgt ttacgaatat atgccgccac atactcctgc
    11581 tcctcccggt tcttttcatc ccattgttgc ggaagctcac cattctgtaa agactgggtt
    11641 cctgccaacg ctaccgtatt ccattctcct ttctcacccg ataaaatgat ttccggagta
    11701 ctgcccatcc acaccccggt ttgcggagta tagcaaagat agacatacga atagatgtaa
    11761 cgcctgcaag cccggtagaa agccgctgcg ggagagaatc ccggctctct cctcaccgtc
    11821 attctgcggg atagtaccaa cttatcaaaa gtacgttccc tcaaagccct gataaagaca
    11881 tcgaaacaag cctcataggc tttcttcgct ccgagtgacc ggtcgcttcg gagctgttgc
    11941 ccgtacgatg ccgcatcgtc cccctgtgca ggggtatgca agtttccggc gcaggaagga
    12001 atctcgtgac aatccggccg gatcaatatg ataggacatt gcggagtgac ccggaaaggg
    12061 gcgatgacaa agcctgtccg accattcaaa tcttccattt tccggataag gtgtacttct
    12121 ccgcaagtct gcatcagaaa gtgaggttcc tcttcgcccg gattacgata cattgcgaag
    12181 ctccttccct gacggatcaa ttcatctata atctcacaat tatttgtttc ttctaacgtc
    12241 atctcttctt taatatacta ttcactaccc gtatggaaga caccaacttg tccgtcgacg
    12301 taaatacgtc cacattccag acatgtgatg aacgtccttt gtggataatg gtaccgacgg
    12361 cacgtacggt atctccctcg tgggcagatg acatgtggtt accgctgacc tgcataccaa
    12421 ccacaatctc gtcgggctgg cagagaatca tcgaacccag tccggcaaca gtctcggcca
    12481 gtgccaacgt ggcacctccg tgcagaatgc cgaaaggctg acgggtccgc tcgtctaccg
    12541 gcatagtagc ctctacccgg tcttcggaag cataggtata ttgaatgcc
//
