LOCUS       gnlProkkaLJHKLNHC_105  10762 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LJHKLNHC_105.
ACCESSION   gnlProkkaLJHKLNHC_105
VERSION     gnlProkkaLJHKLNHC_105
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 07:34:24
            Original ID  :: gnl|Prokka|LJHKLNHC_105
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10762
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10762
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1448:5762]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1449..5762
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10762
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10762
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..226
                     /locus_tag="ctg105_1"
                     /transl_table=11
                     /translation="MSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKK
                     GNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             237..1385
                     /locus_tag="ctg105_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1449..2168
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2189..3490
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.9e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.4e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3507..4631
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4641..5762
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg105_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4731..5738
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg105_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg105_6_Aminotran_5.1"
                     /locus_tag="ctg105_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5759..5902
                     /locus_tag="ctg105_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6105..7589
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg105_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7543..8802
                     /locus_tag="ctg105_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8811..9560
                     /locus_tag="ctg105_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9560..10600
                     /locus_tag="ctg105_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 ttattctgat aatgcaagga agagtaagaa attcattgtt tacatgaatg gtcaggtgac
       61 gaaggttaag ggtagtggta agaaacagat tgagccgggg tgtgagatta ttgtgcctgg
      121 taaggctaag aagaaaggga acatagctaa tattttaggt tatgctactt ccttcagttc
      181 tttgggaatg atgattgctt ctattgctaa tttgataaag aaataaatga cctattatga
      241 ttgaaaagca atcttatcaa gaaccgtttt ctgaagtgga taaaaggaaa gatgatgaaa
      301 tggaaataga cttgatggct attttttata agattattac tgttcgtgga gtactatgca
      361 aagctgctgg agtgggagta ataattgcta tagtggtggc attgagcatt cccaagcaat
      421 atacagtaaa ggttaccctt tctcctgaaa tgggtaatgc gaagggaagt aatggtttag
      481 ccggacttgc tgcctcgttt ttgggagatg gggctctaat aggggaaagc acagatgcct
      541 tgaacgcttc tctttcagca gatattgttt cttcaactcc ttttttattg gaacttttag
      601 aaatggaagt ctccgtttct aaaaaggatg ataaaatgac tttggggtct tatctcgatg
      661 aagagtcatc tccttggtgg gattatctta taggttttcc gggcatagta ataggaggag
      721 ttaaatcatt attcggagaa gatacggttc ctgccagtgg agggcggcaa ggaactatcg
      781 aattgacgaa agaagtaaat gagaagatta attttcttaa aaagaagatt agtgcatcca
      841 ttgataagaa aaccgccata acgagcatta cggtcacctt acaaaatccg cagatcactg
      901 cggttatagc agattctgtc gttcataaat tacaggaata tattattggg tatcgaactt
      961 caaaagtaaa agaagactgt gcgtatttgg aacggttgtt taaagaacgt cagcaggaat
     1021 attatgctgc tcaaagaaaa tatgcggatt atgtagacgc ccatgataat gtggttcttc
     1081 aaagtgtacg tgctgagcag gagcgtttac agaacgacat gagtttggct tatcagatat
     1141 atagtcaggt tgctaatcag ttgcaggtat ccagagccaa agtacaggag gaaaagccag
     1201 tctttgcagt agttgagcct gccgttgtac ctttgaaacc ttcaggtatg ggactcaaaa
     1261 tttatatttt attatttgtg ttcctgtccg tatctggtac tctcgtgtgg gtgttttttg
     1321 gcaaaagtct gctggctagc ttgagaaaag aactgaaaaa taaggagata gaacaggata
     1381 aatgatgcta aaacgtcgtt tacaacattc ttacatcaat taaattcact tactatatta
     1441 ttaaacgaat gatacgtaca gctatgataa tggctgcggg catgggaacc cgttttggcc
     1501 aatatacaga attgatacct aaagggttcg tcaaagtggg aggtattcca atgatagttc
     1561 gttctattga tactttgtta tcatgtgaca ttgagcgaat tgtaatcggt acaggatata
     1621 aacaagaagt ttatgaagaa ttgaagacag actatcctat gcttgaaacc tgttttagtc
     1681 ctcgttatgc tgaaacaaat agtatgtata ctttatataa tacgcgggag attctgggca
     1741 atgatgattt tttattgtta gagtcagatt tgatttttga gaaacaagca ataatgagct
     1801 tattggagtg tcctgcggca gatgcaatgc taataactcc agtgacaaag tttcaagatc
     1861 agtattatgt ggaacatgat gataattttc gcctttcttc atgttctgtc aataagaata
     1921 aactaaacgc taaaggcgaa ttggtcggca tccataaact atccggttcc ttttacaaaa
     1981 taatgtgtgc tgattatgcg agtattgttg atgaacaacc caatttggga tatgagtatg
     2041 aattactacg aatatcttgt tctcaatctc ctgtttatgt gcataaagta gaagggctga
     2101 aatggtatga aatcgatgac atatcagatt tggaatatgc agagaaatat attgttccgt
     2161 attgttaatt aaaataatat atcaaattat gagtaagaca gtttatattg ggatgactgc
     2221 ggatattatg catccaggac ttatccgcat tattaatgag gctactaaat acggtgatgt
     2281 tataattggt cttcttacag ataaagctat tgcggagcat aaacgccttc cttatctgac
     2341 ctatgaacaa cgaaaagagg tagttcagaa tattaaaggc gtatgtaaag ttgttcctca
     2401 agaagaatgg agctatgttg agaatctcaa acgcattaaa cctgactata taattcatgg
     2461 tgacgactgg aaaaccgggc ctttacgtga agaacgtgtg cgcgtatttg aagtgatgaa
     2521 tgaacaggga ggaaaggtta tcgaaattcc atatactttg ggaattaatt catcttcttt
     2581 ggataaagat attaaggcta taggtacaac ccctgatgta cgtttaaaat cacttcgtcg
     2641 tttgataaat gccaaacccg tagttcgtat tttggaagct catgatggac tatgtggctt
     2701 gataattgaa aatcaggaaa tattaaaagg ggataagagg gaagtatttg acggaatgtg
     2761 gtctagtagc cttacggatt caaccagtaa aggtaaacct gatattgagg cggttgattt
     2821 aactacccga ttgcaagatt tgaataatat tctggagtgt actactaaac ctattatttt
     2881 tgatggagat acaggtggta aaattgaaca tttcgtattt acagtacgca ctttagaacg
     2941 tcatggaatt tcagctataa taattgaaga taaagttgga ttaaaaaaga attcattgtt
     3001 tggtacagat gttattcaaa ctcaagatac aatcgaaggt ttctgtaata agatcaaagc
     3061 aggaaaggca tctcagatta ctgatgattt tatgattatc gctcgtattg agagccttat
     3121 agcgggaaag ccggtaagtg atgctttaga gagagctttt gcatatgtcc aagcgggagc
     3181 ggacggtatt atgatacata gcaaaaataa gtcgggtgaa gatataaaag aattttgttt
     3241 ggcgtttcga aaacagtatg ctcatgtacc tatcgtggtt gtgcctacta catatgatca
     3301 tatttatgag tctgaattgt gtgattgggg tgtgaatata attatttatg ctaatcatat
     3361 gcttcgtgcc gcttatcctg ctatgatgaa tgtcgcaaag ataatattag agaatgaacg
     3421 tgctttagag gtgcgcgaac tgtgtatgcc cataaaagaa atattggaac tgattccagg
     3481 tactaaataa aaagaggaat atcattatgt taagcgtaga aaaagtttat gaaacgtttc
     3541 tgagtcatga cgttgatttt tttacaggag ttccagactc attactaaaa aatatttgtg
     3601 cctatatcac agaccatact tcacgtgaga aacatatcat agctgctaat gaaggtgcgg
     3661 ctgtaggaat tgcttcaggt tattatatgg catcaggtaa ggttcctgtg gtttatatgc
     3721 aaaattccgg cttgggtaat actgttaatc ctctgctgtc tcttgcagat gaacaagtat
     3781 acagttttcc aatgcttttg atgattggct ggcgtggtga accgggaaca aaagatgaac
     3841 ctcagcataa aaaacagggt gaggtaactt tagatttgtt gaaagcaatg cggattcctt
     3901 atataattct tgattcaaat gagaatgatg catttattca gctccatgat atcatacaat
     3961 cagcaaaaac taagaatatt cctcatgcaa taattattcg gaaagatgtt tttggcaaat
     4021 ataaacttca aaaagagttc ggatgtaatt atcctttatc tcgtgaggat gctttgcaaa
     4081 tagttgtgga ttatctgcct gaaaattcag tggtcgtttc tactactggc aagctttctc
     4141 gtgagttatt tgaatatcga gaaatgaaag agcaaggtca tgaacatgat tttctcacgg
     4201 taggctctat gggacatagt tcatcaatct ctttgggtat tgctatagca aagcaagata
     4261 gacctgttta ttgcttggat ggtgatggag catttattat gcatttaggg gcaattagta
     4321 acattggcga tttatctcct aaaaactatt atcatatttt gtttaacaat ggtgctcacg
     4381 agtctgtagg aggacagcct actttaggat ttagtttaga tattccggct attgtccggg
     4441 ggagcggata taagcatact tatactgttt gtacaaaagt tgaaattgaa gaagcaatga
     4501 agcagcttcc aaagttatgt ggtcctgttt tgttggaaat aaaggttaaa atagattctc
     4561 gggagaattt gggacgtccc acgactactc ctatagagaa taaggagcat tttatggatt
     4621 ttttaaaata aatatattcg atgaaaatag aaagaaaaat attattaaat cctgggcctg
     4681 ccactactac tgacagtgta aaaatggcac aagttgttcc ggatatttgt cctcgcgaga
     4741 aagaattcgc aggtatgatg aaacaacttc gggacgattt ggtcagagtt gctcatggga
     4801 atttggaaaa acataccgct gtattatttt gtggctcagg aaccatcaat attgatatat
     4861 gtctaaattc tcttcttcct gaagacaaaa gggtgcttat agtgaataat ggggcatata
     4921 gtacccgtgc tgtagaagtg tgtcaatatt atggtttgcc tcatattaat ttggaatttt
     4981 ccgtttacga acgtcctgat ttatcggtgg tggaaaatgt gttgcaagaa aatcctgata
     5041 tagctatggt ttatactact catcacgaga cgggtacagg aattctgaac cctattcgcg
     5101 agatgggcgc tatagctcat aaatatcagg ctaaatttgt cgtcgatact acttcttctt
     5161 tgggcatgat tccttttgat atagagaaag ataatgtgga tttttgtatg gcatctgctc
     5221 aaaaaggact tcaagcgatg acaggtcttt cttttattat aggcaatgag gaacagatta
     5281 agttttcaaa aaaatatccc aagcgttctt actattgtaa tctttatttg cagtatgaga
     5341 attttgagag aacaggtgaa atgcatttta ctccaccggt acaaactatt tacgccactc
     5401 gtcaggcatt aaatgaatat tttgaagtgg gtgaagaagc taagtttgcc cgtcacaaaa
     5461 gagtttttga ggctattcat tcaggtataa atgaaattgg tcttaaaagt gtaataaagc
     5521 gtgaatggca gtcaggactg gttgtctcag ttcaataccc agaagatccc aactgggatt
     5581 ttgagaaaat acatgattat tgttatgagc gtggatttac gatttatcca ggtaagatat
     5641 caactgagga tacttttaga atctgtgctt taggagagat agaagtagat gatattgaga
     5701 acttctttaa agtactaaaa gctgcattaa atcattataa cgtcacatta ccgatgtcat
     5761 gattgcagaa atattattga agattcgtca tttttatttt tcccttcgtg gtatacactt
     5821 ccatccggaa agtgttattt ctggagtgcc tattcgtagc tttcgcttag taggcaaata
     5881 tggcaatatt aatttgaggt gatgcattag gagttcttta ttcttataaa aaggcatcgg
     5941 tagttatagg agataatgtt tgtgtagggt aatttgcttt tagtgggaga gaccatatta
     6001 gaattgcggt aaggggcgaa gaagataata accaattagt gagaatattg gaaaaatata
     6061 attgatatcg gtaaatgtag ttgtttttat actgtattta agtaatggaa aatctaaagc
     6121 agaaaactgt atcaggaata atgtggagcg ctatagaacg tttctcttta caaggagtac
     6181 agtttataat tcaaataata ttagctcgtt tgttactacc atcggattat ggtatgatcg
     6241 ggatgttagc tatttttctt caagtcgctc aagtatttat agatagcggt tttacaaatg
     6301 ctttaatcca gaaaaaagat agaactgaag aggattttgc cactgtcttt tattttaata
     6361 ttcttgtcgc agtattattc tatggtatat tgtttttttc ggcttctttg attgcagact
     6421 tttataatat gccgacttta gttcttgtaa ttcgttttat agcattgtcg ttgataataa
     6481 atgctttatc ggctattcac agaacgaaat taattatttc tgtaaacttt aaaactcaat
     6541 ctaaaatttc attaggtgca gcttttatat caggcgtgat tggaatatgg atggcttatg
     6601 tcggttgcgg ggtttgggct ttagtttggc aaactctctt aaatagtata attttgacaa
     6661 ttttgtttta ctgtttagtt cattggaaac ctttacatac tttctccaaa agttcttttg
     6721 aaagattatt caatttcgga tctaaattat tgatctcaag tcttatcaat acagtatatc
     6781 gtaatctgta taccattgta ataggaaaaa agttttctgt tgtagagctt ggttactata
     6841 caagagcaga acaatttgct atttttcctt ccaataattt aaatgcttta gtttctagag
     6901 tagcgtatcc tattttaagt tccattcaag atgatgataa atgtttaaca aacgcatatc
     6961 gaaattatat cagattatcc tcatatataa tttttccttt aatggtaggt ttacttgttt
     7021 tggctaatcc tattattagt ctattgttaa cagataaatg gtctggggtt gttattcttt
     7081 tacagatatt atgtttggat tggatgtttg atcatttgag ccaaattaat ttgaatttat
     7141 tatgggttaa aggaagatct gatctgtcgt tacgtcttga aataataaaa aagacgattg
     7201 ctatattcat tctttttgtg tcaattccat ttgggcttga ggtgatgtgt tggggtagag
     7261 ttatttactc tctgatagcg acatatttga atacatatta tactaattct cttattgatt
     7321 tgaccttaaa gttgcaagtt aaagatgtat ttccaagttt aatactctct ttcataatgg
     7381 gggggatcgt ttttatatgt atttctttct ttgaaactga tatagtaaaa attgtgattg
     7441 gatgtattac tgggatgtcc ttctatattt tactttcttt tctttttaag ctagattctt
     7501 ttttttgtat tttaacattg atcattaaaa ctaaaaacat agatgaaaat attaaaaaag
     7561 atttttcaag taatagtaaa gataattaac cattgtgtgc cagttgatag tagatcattg
     7621 tattttattc ctcatcctaa ttgtagaaca gataaatatg atattataaa ttattcgtca
     7681 gataatgttc tcgttctgtt aaattatttg ctaaaaaaag atagtgctga atattataaa
     7741 atatatgttg aaatttatga ttcttctcgt atttcagaat atcaagaata tatttatggc
     7801 ataaatccta atattaggtg tactttttta tgtgcatgtg ttggacgttt tttctttaat
     7861 aaagtatctt ttaaggatat gttgtatgcc tttttttgtt tttgtagagc aagtaaatgt
     7921 tttacagcta ctttttatta tgatttttca tttaaaaaac gctctcaaca gattatttgt
     7981 ttggggtatt atactccatt caaagatgat tatcatatgg gagatcattc ttatgataaa
     8041 tttcgtaata caacatgtaa ctcatttgat tactctattg ctacttcttg tttaagtgct
     8101 agaataattt caatagattg tggaatctca tatgataaat tcaaagtctt aggatttccc
     8161 agaaatgatt tgttgatatc gaaaaataat tgcaatgtta ttaaaagaga aatttcgaaa
     8221 tttgcgggat atgatgtaac taaatatata gtttatactc caacttttcg tgattatgag
     8281 actgttactg aaggtaattt gcgttcaata ctcggatatg ttgattgtga tttgttgaag
     8341 ttatcgaaaa tactattgaa gtttaatgcg gctttaattc ttaaattaca tcctttgcag
     8401 aataaaacag tcttaaaaaa agatttaccc aaaggtatac ttgtttttga acaaacatat
     8461 aaatatggat tgtatgatct tttgtcattt tcagatggaa tgattactga ttatacttct
     8521 acctattttg attttttatt ggtaaataag ccagtcatat ttaatttcta cgatattgaa
     8581 gaatatcgta gagtaagagg tttctcattt gagccaatag aatttttttg tgcaggtgat
     8641 attgtttaca attataatga attgatagat gctgtgatgg gacttctggc tgggaaagat
     8701 attcatgctg aacatcgacg tcatatttct ttattgatga atcaatttca agatgataat
     8761 tcaacaaaga gaatatgtga catattttta aatgaaatat aataaataaa atgaattatg
     8821 catttgtggt gcaggcacgt ttaggttcta cacgtttgcc tggaaaaata ttgaaacctt
     8881 tctatggtaa tcaatcgatt cttgacttaa tggttcataa gctttctgct atatcgaata
     8941 ttccagtaat tattgctaca acaaattctg ttatcaatga acctattgaa aagaaggcac
     9001 ttgcattagg ggtaaagtgc ttcagaggtg aggagaatga tgttttaaaa cgattcattg
     9061 atgttgctga atattttgat atacagggta tattccgaat atgttctgat aatccatttt
     9121 tagatgtaca tgcggcaagg caattggtcg aaatagcaat gaaatcttgt aacgattata
     9181 taagttttga tattgatggt actccatcaa ttaaaactca tttcggtttt tggggagaat
     9241 ttgtaacgct tgatgcgctg aagcgagtta taggatttac tgatgattta ttgtatcgtg
     9301 aacatgttac taattatata tatagtcatc ctgaactttt taatattcaa tggatttcag
     9361 gatctccagt cgtgtcaaaa catcataata ttcgactcac gattgatacg ttagaagatt
     9421 tttctgtagc acagagaata tatagggatt tacaagaaaa aagagtggaa atatcgatag
     9481 aagtgattgt agactatgtt cgaagacatg cagaatacat tcaactgatg aaacaacaaa
     9541 taaaaaaaaa ttctaaataa tgaagaatac ttatattatt ggtgaaatag ggcagaatca
     9601 taatggttct gttgacttgg ctaagttgat tattgaatta atctcacgac ctgtacatga
     9661 ggatgttttt ggtatggatt tcatgccaat gaatgctgtt aaaatgacta aaagagattt
     9721 atcagaagaa ttggctgttt ctcaaatgaa tcaaatatat gacaatccta attcttttgg
     9781 gcgtacttat ggtgaacatc gtgcttttct tgagcttgat gatcaagcgc attttgagat
     9841 ttataaatat gctaagtcat taggattaga ttttatcgag acgttatgtg ccaaaggatg
     9901 tctgtctttg cttaaactgt tcacaccgga taggctaaaa gttgctagtc gtgatttgac
     9961 taacttacca ttgcttgaag cattagcaga aactcatatt cctattatat tatcgacagg
    10021 aatggctggt caaagagaac ttgacaatgc attagatgtg ataacgagat atcatagtaa
    10081 tatagctatt ctacattgtg tatctcagta tccaactcat ccaaataatt tgaatctacg
    10141 tacaataaca tatttgaaga agcattacaa taagtttgag ataggttttt ctgatcatac
    10201 aataggtatt tctgctgcta cagctgctgt agcgatggga gcggaaatta tagaaaagca
    10261 tgtaacaatt gatcggcata tgaaaggaac agaccagctt ggctctttag gtccagatgg
    10321 ggttaatcgt atgattcgag atattcgcat agcagagtgt tggcttggta ctgaagatct
    10381 ttatatagaa aaaggggtgg agaagtctaa gataaaactt gaacgttcta ttgccactcg
    10441 aaaatatatt ccagcaggta gtattattca agagtcggac attcatttac tgagtcctgg
    10501 tgatggttat aaatggatag ataaaaaaaa tgtaattggt cattttgcta aacaagatat
    10561 atcagcgaat gaaataatat atcctgattt tattgaatag atatattcct actgcaactt
    10621 gtattacggt atagagtact gcctgctata agctaagtag tgattaataa ataagggtaa
    10681 aatactaaaa aaatgaaaga gataaagctt atacttacag atattgatgg cgtttggact
    10741 gatggcggaa tgttttatga tc
//
