LOCUS       c00053_gnlPro..        16602 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LJHKLNHC_53.
ACCESSION   c00053_gnlPro..
VERSION     c00053_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 14:00:36
            Original ID  :: gnl|Prokka|LJHKLNHC_53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16602
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16602
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3044:6602](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3045..6602
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16602
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16602
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(472..1626)
                     /locus_tag="ctg53_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGADQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGAFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1779..3011
                     /locus_tag="ctg53_2"
                     /transl_table=11
                     /translation="LQILKKALYLPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEI
                     DWSDRLIGIKGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQK
                     RGGKVLLIDQVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNL
                     RGFSFREFLNLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFL
                     EKRNFSENLLKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDV
                     QTSRATVMNYIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVL
                     DTFFVNTLWKDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGN
                     QIPLWMFGFLY"
     CDS             3045..6602
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_3"
                     /sec_met_domain="PFOR_II (E-value: 9.9e-19, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.4e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.6e-31, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.9e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.1e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 9.2e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.4e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6727..6915
                     /locus_tag="ctg53_4"
                     /transl_table=11
                     /translation="MIGFVIWIVGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(6926..7759)
                     /locus_tag="ctg53_5"
                     /transl_table=11
                     /translation="MFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMTNLAKAIFED
                     QGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVIGDIYDGARI
                     GLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLDYKLMTSSGP
                     AMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNAETIHTIAWKGFSEK
                     DPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSWIPKKD"
     CDS             complement(7814..8563)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.1; E-value: 1.2e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg53_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 4.2e-29, bitscore:
                     92.1, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIGGFIDGFQHVLFGIPFYITIAVLAALAWFKSGKGTAVFTLLG
                     LLLIYGMGFWEETMQTLALVLSSTCLALLLGVPLGIWTANSDRCNKIMRPVLDFMQTMP
                     AFVYLIPAVLFFGLGTVPGAFATIIFAMPPVVRLTGLGIRQVPKNVVEASRSFGATPWQ
                     LLYKVQLPLALPTILTGINQTIMMSLSMVVIAAMISAGGLGEIVLKGITQMKIGLGFEG
                     GIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8641..9867)
                     /locus_tag="ctg53_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKEEREKKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10341..11627
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFMRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFVAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVAMGIVLLTLPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFHKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11590..11922)
                     /locus_tag="ctg53_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(11950..14523)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 59.4; E-value: 1.3e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 4.5e-19, bitscore:
                     59.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEIRSAGDDNTKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEEA
                     YQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGSTP
                     AMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIAP
                     GAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDIL
                     EKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVVL
                     YGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQL
                     EEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLRL
                     VNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHTL
                     ADMEKLERIYFNLLSNAFKFTPENGRIAVRLSSLCKEDKRWIRFTVANTGSMISAEHIR
                     NVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGTISVESDEKQGTVFTVELPVQSCEAVA
                     AEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKSSVLIIDDNEDIRSYVHTLLHTDYTV
                     IEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSLD
                     EQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKD
                     FVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAA
                     SLLASSDMTVAEIGYEVGFSSPSYFTKCYKEQFGESPTDFLKRKG"
     CDS             complement(15036..16262)
                     /locus_tag="ctg53_11"
                     /transl_table=11
                     /translation="MFFSLIVPLFLSLFYKPIAYLCGRSLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 gttcaagctg ataaggacta aaggtcatgt cactcttttt catcttttat tcattttagt
       61 tgatacttat agtagtcaac caaatccagg gtaagacaac tactgttgat ttgattgact
      121 taaccgcatg ttccaatcac attgaacgca tcagctactt caatagtact gctctctctg
      181 aaaacattaa atcatatatc agtcaataat acataaatta tcagtcctta atacttgatt
      241 tctcaattat taatatctga gaaatcaaac gttaacagtt gagatatcag atattaacat
      301 cctgtaaatc aaagaataac acagtaaaaa cggtatttat caggacgatg cagagtgaga
      361 gcaagtcctt gctctcactc tgctaccact ggatctctaa cagctaaaac atcgatgaat
      421 aaagggatac agacgaactg ttagagcatg agagcaaaag cactatcttt ttcactgggg
      481 gagagtaagc aaaagaaacg cacgataccg gctttgaggc gtcaccggta ctaacggcaa
      541 atatccggca cacacccgat tattctctac ggacaaaggg aacgaagccg acatctgccg
      601 atgttcctcc aaagcctgac cggctaaagg ataataatca atccgaaaag ctccttccgc
      661 atccgcagcc aaataacgat ccgtcaagag ccatgccacc acccccatat tcattcgcag
      721 attaatttcg acacaaggat gaatccggta aacaggcgct tcatccggaa aatgacaaat
      781 catcatatcc actcccaagt atccatgata aaagccaccg aacaaagctg acaattcttc
      841 ttccaaacga gtccgcagcc tgataaattc ttcttgtggc acataagccg atagtttctg
      901 cagaatcttc tcgtcagaca gcaagtcatt ccctgcatac atcccactcc cacccgtgtg
      961 gaagaccgaa tatccggcaa aaacaaccct tcctctcccg tcagcataaa actccatagc
     1021 gaaatcttcc accttattat atataggttc gcctaccacc ccaccctgag aagcagcgac
     1081 acgggcacac caaccggaaa taaaagtagt aaatatgcct ttacaccaat tcaatccttt
     1141 cccgcttccg gaaagcggag cttttaacaa gcacgcttcc cgcccttcga cgaacgcact
     1201 gcactccgcc aaagtactca aataaaaaga ttctccacag aagtattcat tcaaccgcaa
     1261 cccaggcaac aactttaccg cctgcagacg atgcgaatgc tctctcagaa tattcatata
     1321 atccgcagaa ggcagctccg tctgatctgc ccccaatgtc atcaaacgct tccgcaaagc
     1381 agggtcccac ccccacggag agaacttccg gtctttaccg tcagccactt ccggttccgt
     1441 caacaaggcc acatccatgc ccaaaagttc actctttgtt ttcaggaagt ccgcattata
     1501 agcagacggt gcaagcaccg cacttcccgc ttcggcatac cacataggaa gcaacgccag
     1561 gtcactcgcc atctgtcggg cggaagccgg cgccatatag ttcgtctcac cgcttgccaa
     1621 cgccatatca tgctccggat tgaatatata aacaggtctt ttcgtcatgt caaagatgga
     1681 ttcaacacat tattctgcaa atatatacag gaaataatca ggaacttaca caataaagag
     1741 aaacttataa attaaagcac atttttgcta tctctacttt gcaaatccta aaaaaagcac
     1801 tatatttgcc agccgaaaaa caaagaaacg aaatggaatc attctatcgc acacacgcct
     1861 acctcgttga gcacaccaat gcccccgttc gccgcgatct tatggacgag atcgactgga
     1921 gtgaccgtct gattggtatc aaagggacac gtggcgtagg aaaaaccact ttcctcctgc
     1981 agtacgccaa agagaaattc ggcaccgacc gttcctgtct gttcatcaat atgaacaact
     2041 tttatttctc cggtcacagc cttgttgact tcgccaacga gtttcagaaa cgtggcggaa
     2101 aagtactgct gatcgaccag gtgttcaaac atcccgaatg gagcaaagag ctacgaatgt
     2161 gctatgaccg tttccccagc ctgaagattg tcttcaccgg ttcttccgtc atgcgactca
     2221 aagaggaaaa cctcgaattg cgtgacattg cgaaaagtta taacctgcgc ggattctctt
     2281 tccgtgaatt tctgaacctg cagacaggaa tgaaattccg ggcatacagc ctcgaagaaa
     2341 tcctcagtac acatgaacag atagccaaag gagtactttc caaagtacga ccgctggatt
     2401 attttcagga ttacctgcat catggtttct accctttctt ccttgaaaaa cgtaatttct
     2461 cggagaatct gctgaaaaca atgaacatga tggtagaagt ggatatcttg ctgatcaaac
     2521 aaattgagct gaaatatctt tcaaagataa aaaaattact atatttgttg gctgtggacg
     2581 gaccgaaagc tccgaacgtg agccaactgg caagtgacgt acagacatcc cgcgctacgg
     2641 taatgaacta tatcaagtat ctggcagacg cgcgtctgat taatctggtt tacccgaaag
     2701 gagaagaatt cccaaagaaa ccgtcaaaga ttatgatgca caactctaac ctgatgtact
     2761 ccatttatcc ggtgaaagtg gaagaacagg atgtactcga cacgttcttc gttaacactt
     2821 tatggaaaga ccataaggta cataaaggag ataaaaacgt ctctttcatg gtagacgaag
     2881 tgatgccgtt caaaatttgt gcggaaggta caaaaataaa gaataacccg gacgtgacgt
     2941 atgcgttgca aaaggctgag ataggccgcg gcaaccaaat acctctttgg atgttcggat
     3001 tcttatacta aaaagattta tttacttaaa tatttaattt agttatgact aaacagaaga
     3061 aattcatcac atgtgatggt aaccaagctg cagcacatat ctcgtatatg ttctctgaag
     3121 tagcagctat ctaccccatc actccttctt cgactatggc tgagtacgta gacgaatggg
     3181 ctgccgcagg acgtaagaac atcttcggcg aaacagtatt ggtacaggaa atgcaatctg
     3241 aaggtggtgc tgccggtgca gttcacggtt ctcttcaggc tggtgcattg actactactt
     3301 acactgcttc tcagggtctt cttttgatga tccctaacat gtacaagatt gccggtgaat
     3361 tcttgccttg tgtattccac gtttctgctc gtacactggc ttctcacgca ttgtgtatct
     3421 tcggtgacca tcaggacgta atgtcagctc gtcaaaccgg cttcgctatg ttggcagaag
     3481 gttctgtaca ggaagttatg gatttggcag gtgttgctca tctggctact atcaaatcac
     3541 gcgttccgtt catgaacttc ttcgatggtt tccgtacttc tcacgaaatc cagaagatcg
     3601 aaatgttgga aaacgacgac ctcgctccgc tgatcgacca ggaagctttg gctgaattcc
     3661 gtgcccgtgc actgaatccg atgaagccgg ttgcccgtgg tatggctgaa aaccccgacc
     3721 acttcttcca acatcgtgaa tcatgcaata actactatga agcagttcct gctatcgtag
     3781 aagaatacat gaacgaaatt tccaagatca caggccgcaa atacggtttg ttcgattact
     3841 acggtgcaga agatgcagaa cgcgtaatta tcgcaatggg ttctgtaact gaagctgccc
     3901 gcgaagctat cgaccacttg gtagcaaacg gcgaaaaagt aggtatggtt gccgtacact
     3961 tgtatcgtcc gttctctgct aaacacttcc tggctgctgt acccaagact gcaaagagca
     4021 tcgcagtgct tgaccgtaca aaagaaccgg gtgctaacgg cgaacctctt taccttgacg
     4081 ttaaagactg cttctatggc gcagaaaatg ctcctgttat cgttggcggt cgctacggtc
     4141 tgggttcaaa agataccact ccggcacaga tcatctctgt attcgaaaac ttggctatgc
     4201 caatgccgaa gaaccacttc actatcggta tcgtagacga cgttacgttc acttctcttc
     4261 ctcagaaaga agaaatcgct ctgggcggtg aaggtatgtt cgaagctaaa ttctacggtc
     4321 tgggtgctga cggtacagta ggtgccaaca agaactctgt taagattatc ggtgacaaca
     4381 ccgacaaaca ctgtcaggct tacttctctt acgactccaa gaagtcgggt ggtttcactt
     4441 gttctcacct gcgtttcggt gatactccga tccgttctac ttacttggta aatactccga
     4501 acttcgttgc ttgtcacgtt caggcttacc tgcacatgta cgatgtaaca cgtggtttgc
     4561 gtaagaacgg ttctttcttg ctgaacacca tctgggaagg cgaagaactg gctaagaacc
     4621 tgcctaacaa ggtgaagaaa tactttgcac agaacaacat ctctgtatac tatatcaacg
     4681 caactcagat tgcaatggaa attggtctgg gcaaccgtac caatacaatc cttcagtctg
     4741 cattcttccg tatcacaggc gttattcctg tagatcaagc tgttgaacag atgaagaaat
     4801 tcatcgttaa gtcttacggc aagaagggtg aagacgttgt taacaagaac tacgctgctg
     4861 tagaccgcgg tggtgaatac aagactctga ctgtcgatcc tgcttgggct aacctgccgg
     4921 atgatgcaaa agcagaaaac aatgatcctg ctttcatcaa cgaagtagtt cgtccgatca
     4981 atgcacagga cggtgacttg ctgccggtat ctgcattcaa gggtatcgaa gacggtactt
     5041 ggtatcaagg tacttccaaa tacgaaaaac gtggtgtagc tgcattcgtt cccgaatgga
     5101 atgctgaaaa ctgtattcag tgtaacaagt gtgcttacgt ttgtcctcac gcttctatcc
     5161 gtccgttcgt actcgatgct gaagagcaga agggtgctaa gttcgagcaa ctgaaagctg
     5221 taggtaaagc attcgatggt atgacattcc gtattcaggt agacgttctc gactgtctgg
     5281 gttgcggtaa ctgtgccgac atctgtccgg gtaatccgaa gaagggtggc aaggcattga
     5341 ccatgaaaca ccttgaaagc cagttggccg aagctgataa ctggacttac tgcgctgaaa
     5401 acgtgaagag caaacaacac ctggtagaca tcaaggctaa cgtgaagaac tctcagttcg
     5461 caactccgtt gtttgagttc tcaggcgctt gctccggttg tggtgaaact ccgtacgtga
     5521 aactgatttc tcagttgttc ggtgaccgtg aaatggttgc taacgctaca ggatgttctt
     5581 ctatctactc aggttcagtt ccttctactc cgtacactat gaacgaaaag ggtcacggtc
     5641 ctgcatgggc taactccttg ttcgaagact tctgtgaatt tggtctgggt atggaactgg
     5701 ctaacgaaaa aatgcgtgcc cgtctggtga aagtaatgaa cgaagctatc gcttctgatt
     5761 gctgcccagc tgaatacaaa gaagtattcg ctgaatggat caacaatatg ctggatgcag
     5821 aaaagactaa ggaactggct gaaaagatca ttccgatggt agaagctgct aaagataaat
     5881 gcaaccactg caagcaaatc gctgatctgc aacaatatct tgttaaacgt agccaatgga
     5941 tcatcggtgg tgacggtgct tcttacgata tcggttacgg tggtcttgac catgtaatcg
     6001 cttccggtaa ggacgttaac atccttgtat tggatactga ggtttactct aacacaggtg
     6061 gtcagtcttc taaagctact ccggtaggcg ctatcgctaa gtttgctgct gcaggtaagc
     6121 gtgtacgtaa gaaagacctc ggtctgatgg ctactactta cggttatgta tatgttgctc
     6181 agattgctat gggtgctgac caggctcaga ctctgaaagc catccgcgaa gctgaagcat
     6241 atccgggacc atcactgatc atcgcttacg ctccatgtat caaccacggt ctgaaagccg
     6301 gtatgggtaa gagccaggaa gaagaagaaa aggctgttaa gtgcggttac tggcacttgt
     6361 ggcgttacaa ccctgctttg gaagaagaag gcaagaatcc gttccagctg gatagcaaag
     6421 aacctaactg ggaagacttc caaggtttct tgaagggtga agttcgttac gcttctgtaa
     6481 tgaaacaata ccctgctgaa gctgaagaac tgtttaaagc tgctgaagaa aacgctaaat
     6541 ggcgttacaa cagctacaaa cgtcttgcca gagaaaactg gggagctgat acagctgaat
     6601 aataagtaga aatactttgt acataataaa aggcaggaat cctggaaaca gattcctgcc
     6661 ttttttgttt atatattaga agtaacgatt acttctcacg aagatattca ttaaaactct
     6721 aaagatatga tcggatttgt tatttggatt gtcggtttga tactgacttt cagagctgcc
     6781 atagagattt ggaatataaa tgcggctgta gagaaaaggc ttatagcgat tgtattaatc
     6841 gttcttacca gctggctggg actacttttc tactacttct atggtaaaga aagaatggcg
     6901 ggatggttga agtagtgttt gcttatcaat ctttcttagg aatccaactg tttaccagtt
     6961 cctgatgttc ttccatccat tgacgggcag cctgtctttc cgtcgtctgc gcctcttcca
     7021 gagcagtcat taaagagctg atttccgcat cagtcagacg aatattgccc agaagttcgg
     7081 cagcaaaagg atctttctcg ctaaaacctt tccacgctat ggtatgaatg gtttccgcat
     7141 ttccatatat cagcttcggg tcctgaagaa ctttcagttt gaaacggtcg aacatccagt
     7201 gaggcgtcca tcccgtcacg acaatccagt ctttcttatc aatcgctttc tttagggaag
     7261 cagtcatggc aggtccgctc gaagtcatca gtttataatc caatccatag tctttgatgg
     7321 cctgatcggt agctttcata ataccggctc cggcatcaat accgacaatc tgaccggaga
     7381 aacgttcctt ttccgcgttc agttcttcga tcgagttgat cgtaacgtaa tccggaacca
     7441 ccagcccgat acgggcacca tcataaatat ccccgataac ttcgagttta tccccgtatt
     7501 gtttcatata atcttccata gtgacaggca tccagacatc cataaatacg tctgctttct
     7561 tacgggagat agaggtaaat ataggtgcaa ggtcggcatt cagcaacttt acatcgtatc
     7621 cctgatcttc aaaaatcgct ttggcaaggt ttgtcatggc aatcccttcc gaccagttgg
     7681 cataagcgat acttatcttc ttactctttc cgttgtctcc gcaggaaacg aaggttaaga
     7741 gtatgccggc aataaacatt gccgcaatca tttttatctt attcattgat tattcctttc
     7801 tttggtgtga ttcttatttc tttttacttt ttctgttatc tgccatgccc tgagtgatgc
     7861 ggtccagcac gatcgccaat atcacgactg cgataccgcc ttcaaatccg agtccgattt
     7921 tcatttgggt gatacctttc agcacgattt ctcccaatcc tccggcagaa atcatggcgg
     7981 caatcactac catcgaaagt gacatcatga tcgtctggtt gattcccgtc agaatagtag
     8041 gcaacgccaa aggcaattgt accttataaa gaagctgcca gggagtagct ccaaaagagc
     8101 gggaggcttc tactacgttt ttaggaacct gacgaatgcc caggccggtc agacgaacca
     8161 caggaggcat tgcaaagatg atggtggcaa aagctcccgg cacagttccc aatccgaaga
     8221 atagaacggc aggaatcaga tagacaaagg caggcattgt ctgcataaag tcgaggacag
     8281 ggcgcattat cttgttacaa cgatcactgt tggcagtcca gattcccagc ggaacgccta
     8341 aaagcaatgc cagacaagtg gaagaaagta ctaacgccaa tgtctgcatc gtttcttccc
     8401 aaaagcccat gccgtaaata agcaataagc ccaagagggt aaatacggct gtccccttac
     8461 ccgacttaaa ccaggcgagc gcagccagca ctgcaattgt gatataaaaa ggtattccaa
     8521 acagtacgtg ctgaaaaccg tctatgaatc ctccgatccc catgctgaga gcatcaaaaa
     8581 aggaagcaaa atgttctgtg agccaattaa tggcagtttc tatatattgt ccgatattta
     8641 tcataattct attgcgtttt gaatgatttc attaatttct tctttatctt ttcccgttac
     8701 ttcgatgatc aatgaggaaa gtggcactac gccttcaaac tcccgattct catttacgac
     8761 ccagattggc gagttcgttt ttgtcatcaa cggaagaata tcttccagca ccgtatcacc
     8821 cagcactgaa tgaacttcat gccttactac ggactcgatg gagcggattt gctcttttcg
     8881 tagtttcagc aagtcattca accgcacctc tcctactaac agattattgg aatcgactac
     8941 cggaagaacg gtcagattcc gttcgcgcat cttacggatc agcacctccg ggccttcttt
     9001 cttcaaacgt gccactatgg gtttatctac cataacagag gaagctgtta taatcttgct
     9061 tcgatctaca ttctccacaa atcgttctac ataagcgttg gcaggttcgg tcaggatttc
     9121 ttccgatgta ccgatttgta caatttctcc atccttcatg atagcaatcc ggtcacccaa
     9181 tttaatcgct tcactcaggt cgtgagtaat aaagacaatc gtttttttca tcttcgactg
     9241 caaagtcagc agttcatcct gcatctgcac acggatcaaa ggatcgagtg ccgagaaggc
     9301 ctcatccatc aacaggactt cgggattatt ggccaaagcc cgcgccagcc cgacacgctg
     9361 ctgcatccca cccgacagtt cacttaccat ctgattctcg tagcctttca gccccaccag
     9421 ttgcatactt tccatcgctt tcttctcccg ttcttccttt ttaactccct gtagttcgag
     9481 tccgaaagct atattatgca agacagaacg gtgaggaagc agaccgaagt tctgaaagac
     9541 catagccagt tctttccggc gaatctgcaa cagttcttta tccgacactt tggctatgtc
     9601 tgttccattg ataatcactt ctccggaagt agggcgtatc aaacggttga tgcagcggag
     9661 taaagtggac tttccactac cggacaaccc cataatgacg aatatttcgc cttcattaat
     9721 ggaaagattc gcatctttca ccgcaaccgt acatccggtc gctttcaata tttcactttt
     9781 agttttacct tctttcaaca tcttcaaagc cttctgcttc tcattgccaa aaaccagata
     9841 gagatcttta atttctattt tactcataca ataaaatggt ttaggttatt aaaataatat
     9901 acacagcaag acaagaacaa acgataacag gaatctttct ttatatcgta taaagttctg
     9961 atttaaatac gggacaaata acaatgaatc ccgaaataat taataaaatg attattgaca
    10021 gactgagtaa ttaaaaaagg aatagaattt gataagataa tcctttcaac gaatagcaaa
    10081 aaaatagcat ttttatgtat aaaaacagtc tgttccagta tcttgctggc acaaagatac
    10141 aaaaaacaga ttaaacatgc aaattatatt caaaatccgg ggcatacaga ggactttatt
    10201 tgtaatgata tggaaagttt ccgggtaata ttcccctatc actcagcaaa atagaacaaa
    10261 ccagcagata aatataaaat aagtttgaat atttcaccta aacaccgtat atttggcgtc
    10321 aataactaaa ctagatttat atgttcaaca gggctattac aattttcctg gggaaggata
    10381 attgtcatta cacaacaaaa gaaaaacaaa caggtactgc cacactagac gacaaaagcc
    10441 aagtacagtt ccttagtaaa aagaacccca aaatgccgtt tttctatagt cggcggaatc
    10501 tctacatgat aggtttcctg ctcgctttta tagtgactct gctcgaattt atgcgaggac
    10561 ggcatcaaaa ctttatggtc ttctcagacg ctactcaatt cttctggcaa ggcatcagcc
    10621 catacacaac cgaatttgta gaagctcacg gacgctactt cctttattct cctgttttca
    10681 cggtattgtt cgctccgttt gcgtatctgc ctgcatggct gggacctttc gcgtggaatc
    10741 tattcaatta ttcattgttc tttgtggcga tcttcacgct gccccaacaa ttcacccagc
    10801 aacagaaatg ccgtatgttc ctttttctgt tactgatttt aggacaaagt ttactttcat
    10861 ttcagtataa cataacggta gcctatttat tcttattcgc ctatacgtta ttggaaaaag
    10921 accgtggatt tctggctgtt ctgttaatca tgatttcggg atgtaccaaa gtatatggaa
    10981 ttttcgaact ggcattgttg ctgtgctatc ctcacgtatg gcgtaacttt ggctatgccg
    11041 ttgcaatggg cattgtattg cttacgttac cgttaatcaa aatagctcct gcagatttgc
    11101 tcccctatta tgaagaatgg tgccatagtc ttgctgttca tcaatccgcc ggagcttatg
    11161 attcattttt ctatgcccgc cccattgcag catggacatt gccacacttc cgtgcacttc
    11221 agataggaat gctcggtcta ctgactctgc tctttttggg gaatttccac aaatggtcgt
    11281 cttttgcctt ccgtgcccaa gctttgggca ttctcatggg ctgggtagta ttactgagtg
    11341 actccgccga gaaacatacc tatattatcg cattggcagg tttcatgctc tggtattgga
    11401 gcaggccaac acgtaccgca acagacaaga ttctattttg gtgctgtttt gtgctgttat
    11461 gcatcgttcc tatcgacata ttcgtccctg ttcccatcag agatttcatt accaggacct
    11521 tatggcttca tgtatgggtt ttctttattg tatggatacg gatgatatgg cttaccttcc
    11581 ttgcatcctt cattcatcca cgtgccacaa atgttctttc agattaacgc atccgttagc
    11641 tttgaaagaa acttcttctg ccagcaagag ttgtttttgt tccacccaac cgggtaccag
    11701 ccttccggtg gaatttacaa ctctatggca aggaatggat aattcatccg gcacttcttt
    11761 caatgcacgc cccaccatcc gcgaacattg gggggcaccc aaaagcaaag caatacctcc
    11821 ataggtagat acttttccca caggtatctg ggatacgact tcgtacactt ccttccgaaa
    11881 ggattcggaa aaactctctt tatctacttt ataatctttc atatatccct ctttacgatc
    11941 tcaatgaaat catcctttcc ttttcaggaa gtctgtcggg ctctctccga actgctcttt
    12001 atagcacttg gtgaaataag aaggtgaact gaaaccgact tcataaccaa tctccgctac
    12061 ggtcatgtcc gaagaagcaa gcaaagaagc tgccttcttc aaacgggcga tacggagcaa
    12121 ttcattcgga gagtagttag tcaacgattt aatcttgcgg taaagctgca cacggcttag
    12181 tcccatatcc ttgcccaagt cctccacatt caaaccggag tctcccattt tctcttcaat
    12241 caatgacttg aatctttcta caaaatcctt gtccatatcg caaacatctt ccttcgccaa
    12301 tgtctgcccg tcaccaaaga actgtttcag acgacggtga gaatcgatca ggttgcggac
    12361 acgtgccagc aacagttgtg aactgaacgg ctttgaaata taagaatcgg caccaccgtc
    12421 atatccctga atacgctgtt cgtccagtga acacgccgtc agcagaataa ccggaatatg
    12481 acaggtctgt aactcacttt tcagccggcg gcaacattca atgccatcaa tgcccggcat
    12541 catcacatcg gaaataatca ggtcaggaac atacttcata gccttacgga ttccttcgga
    12601 gccgtctgcc gcttcaatca ccgtatagtc tgtatgcaac agcgtatgga catacgaacg
    12661 gatatcctca ttatcatcaa taatcagtac ggacgatttg gaagagtcat atcctttttc
    12721 cagttcttcc tcttccgcca atagaacatc tgttgtacgg gaatccgcag aaacaagggt
    12781 ggtatccggt tcggcagcaa cagcctcgca agactgtaca ggcagttcaa cggtaaagac
    12841 cgtaccctgt ttctcatcgc tctctacaga gatcgtacca ccatgcattt ctacgaaggc
    12901 ttttaccaat gccagtccga ttcccgaacc ggtatggtgc atatcgatct tatagaaacg
    12961 gtcgaataca ttgcggatat gttcggcaga aatcatagaa ccggtatttg ccaccgtgaa
    13021 acgtatccat cgcttgtcct ctttacaaag ggaagacaga cgaacggcaa ttcttccatt
    13081 ttccggtgta aacttaaagg cattggacag gagattgaaa taaatacgtt ccagcttctc
    13141 catgtctgcc agtgtatgat aatccgtatc cggcatacta tcaaaagaaa aatggatatg
    13201 cttcttacgg gctgccgcct gaaaagactc attccatcct tcgaaagaag aaaggacatc
    13261 caccgtaacc ggagtatatt ccatcttgcc attttcatat ttacggaaat ccagaatctg
    13321 attgaccaga cgcagaagaa tgttcacatt ccgctgaatc agcatgagca tccggtgctg
    13381 atctccgctc agtgtcttgt ccgccaacaa atgttctacc ggatcggcaa ccaatgtcaa
    13441 cggagtacgg aagtcgtgag aaatattggt gaagaatacc agcttggcat gagtagcttc
    13501 ttccagttga tgagaaagtt gtatcaattg gtcacgctgt tcttccagtt tgtcacgttg
    13561 ctcttccaat tgttgcttct gcttaaaaag ttctttattc aagcgattct ttgagcggag
    13621 tgatttataa acgaccaata ataagccggc taccaataaa aggataatca gactgccgta
    13681 taaaacgacc tgttgtgtag ctacctgaga gagatagcca ccgatacgtc cgttgagcgt
    13741 ttcaatcttt ttgtcgagtt cggaaatgtg tgtggtctgc aactgcatga cgtgtgcgtt
    13801 ggtacggtcc acaacagcgg tattcatcac cgtttctttg ggatagggtt tcttctccag
    13861 aatatccata gccagttgca gtaccttatc accattggtc ggatagataa aggtagcatc
    13921 cagcacactg tccagaacca gctccagccc gtttccctta cccggcaagg catctatgcc
    13981 gacaaaaatc atttccttct cccgccctgc catctttgct gcctgatagg cacccggagc
    14041 gatacgatca ttatgggcat acacagcatc aatcttagga tgcctccgaa gcatactatc
    14101 catttctatc tctgccggac cacgttccca agcagcatcc gctttatcaa tcagctttat
    14161 atccgggaat ttactgatgg cagccataaa tccctgatgc cgttccattg caggagtcga
    14221 accgctcaat cctgtcagtt ctactatatt tcccttccct ttcagactgg aggcaatata
    14281 gtttcctacc gaacgaccga tttcataatt atcggctccg atataggcag tatatttatc
    14341 cgaaagaatc ttccggtcta caagaataac ggggatgcct ttctgataag cttcttctac
    14401 aatcggagtc ataggagcag cttcgttagc ggaaataatc agcagatcga ctccttcgtc
    14461 cataaaataa tggacatctt ccgcctgctt agtgttatca tcccctgccg aacggatttc
    14521 caccgaaaca ccattataaa acatcgcttc ccgaagaatc tcatcattca tcttatgtcg
    14581 ccatgaatca tcgctgcatt gagccacccc aatacgaaaa cggggtgtat cctgccggca
    14641 agccgtcatc ccggttaaac aaaacagcac cagcatccac ttcagatatc tcatcgtctt
    14701 catccatctc atcatttcgt agttctttct gtaatccaat taagaacaaa aataagaaat
    14761 aatactgtaa agttctctaa cttcagctat ttattattct aaaaagaagg aaagcagtcc
    14821 tctttcagac catcggaaag tattaacaaa agtataaagc gtaaaacaaa cacttaatca
    14881 atgttataaa acatagcgtt ttacttggat aatttgcaga tttcacagaa gtccgtatct
    14941 ttgtactgtg tttttcatag tattagattt aaggttaaca aaggttggag caaggcgttg
    15001 ctcctttttt tatgccctga cctttcatct accggttagt tttcatccca ttccttttcc
    15061 agtttaccat caatagtgta gcgtttccat cgtcctacac ggcgaccatt cttatattcc
    15121 ccacattcac gaagctggtc attctttaca taacgagctt cgaacggtcc gttctgcctt
    15181 ccgttcacat aggtagaagt ttcccaataa tcaaagcggt tgctcactat cagccgtcgt
    15241 tccttgccat gcaatctgcc ggcctgatag gtagcttcat atctcaattc accattttcc
    15301 aaattatatt cacggtataa accgtcttta cgatcgttct tcatataata ttctttctgc
    15361 cttaccccac ttccgttggc aaatgagaca tggagtccat cttcttttcc atccagatag
    15421 gtttcaatca tcagcgtatc gccgctttca gcaaaagtag tccaacgacc attcttcttt
    15481 ccattcttat aactacccag tatacgtggc gagccaaacg taaacacgga cgaatattca
    15541 ccgtcctgaa aaccttcttc attgaaataa acggtctcat acaaatcata tgtacctttc
    15601 agaaaagtat actgtttgcc tacctgcttc ccgtccttgt aattatgctc tttccgcaaa
    15661 gtaccgtcag attcgtacga cagttgcttc ccgtgctctt tccccatccg gaagtttctt
    15721 tcactttcca cttttccggt agtaaagtaa cttttgctcg taccgtccag cttaccttcc
    15781 ttataggact tttcttcttt cagcttaccg tcaaacttgg agttaatctt gaagagacca
    15841 tccttccgtc cttctttata acttccttct gttattaata tattgtctac atattctttg
    15901 tatccgccat catagaaacc atctttaaaa gatgccagca cataggcgga atgataacca
    15961 tctatgatgc gatgttcgcc attcaatgct ttttccgttt tcagttcctg aaacaacagt
    16021 ctgccatcgc ctacattgac aacggatacc tgatcgatct tatattcctt ttgcgcaaac
    16081 aaaggaagag caagatataa aaacaaaaat acgttccagc tttttgatct gaggaagttt
    16141 gaaatgtgtt tcataaagta gttttctctt tttgatttat tatttaaaga cctgccgcaa
    16201 agataggcaa tcggcttata aaacaaggaa agaaagaggg ggacaattag agaaaagaac
    16261 atctgttatt atcattctaa taattaacag attaagtagt aaatcaaaac acagggaagg
    16321 gggatattta ctgaaataag aaacagaaaa gaagatgtgt caaaagtaac taaatttccc
    16381 tccttcagga aggaggggtg gctgaaagcc ggggtggtag gtatatttca cagttgaata
    16441 tcaatagctt atgtattcac ctaccacctc cccctacgag tactcctcct tcccgaagga
    16501 ggagagttta gttacttttg acacacctgc tttttgtatt taaagagatt ctacaacaat
    16561 ctgtctttca gaacaaccgg aagttcgggc attgcaccgc tc
//
