LOCUS c00053_gnlPro.. 16602 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|LJHKLNHC_53. ACCESSION c00053_gnlPro.. VERSION c00053_gnlPro.. KEYWORDS . SOURCE ORGANISM . COMMENT ##gutSMASH-Data-START## Version :: 1.0.0-1555cd7(changed) Run date :: 2024-10-06 14:00:36 Original ID :: gnl|Prokka|LJHKLNHC_53 NOTE: This is a single cluster extracted from a larger record! Orig. start :: 0 Orig. end :: 16602 ##gutSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..16602 /aStool="rule-based-clusters" /contig_edge="True" /core_location="[3044:6602](+)" /cutoff="5000" /detection_rule="cds(POR and POR_N and PFOR_II and EKR and Fer4_16 and TPP_enzyme_C)" /neighbourhood="10000" /product="PFOR_II_pathway" /protocluster_number="1" /tool="gutsmash" proto_core 3045..6602 /aStool="rule-based-clusters" /tool="gutsmash" /cutoff="5000" /detection_rule="cds(POR and POR_N and PFOR_II and EKR and Fer4_16 and TPP_enzyme_C)" /neighbourhood="10000" /product="PFOR_II_pathway" /protocluster_number="1" cand_cluster 1..16602 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16 and TPP_enzyme_C)" /kind="single" /product="PFOR_II_pathway" /protoclusters="1" /tool="gutsmash" region 1..16602 /candidate_cluster_numbers="1" /contig_edge="True" /product="PFOR_II_pathway" /region_number="1" /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16 and TPP_enzyme_C)" /tool="gutsmash" CDS complement(472..1626) /locus_tag="ctg53_1" /transl_table=11 /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGADQTELPSADYM NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGAFRIDYYPLAGQALE EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ" CDS 1779..3011 /locus_tag="ctg53_2" /transl_table=11 /translation="LQILKKALYLPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEI DWSDRLIGIKGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQK RGGKVLLIDQVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNL RGFSFREFLNLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFL EKRNFSENLLKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDV QTSRATVMNYIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVL DTFFVNTLWKDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGN QIPLWMFGFLY" CDS 3045..6602 /gene_functions="biosynthetic (rule-based-clusters) PFOR_II_pathway: POR" /gene_functions="biosynthetic (rule-based-clusters) PFOR_II_pathway: POR_N" /gene_functions="biosynthetic (rule-based-clusters) PFOR_II_pathway: PFOR_II" /gene_functions="biosynthetic (rule-based-clusters) PFOR_II_pathway: EKR" /gene_functions="biosynthetic (rule-based-clusters) PFOR_II_pathway: Fer4_16" /gene_functions="biosynthetic (rule-based-clusters) PFOR_II_pathway: TPP_enzyme_C" /gene_functions="biosynthetic-additional (rule-based-clusters) Fer4" /gene_functions="biosynthetic-additional (rule-based-clusters) Fer4_4" /gene_kind="biosynthetic" /locus_tag="ctg53_3" /sec_met_domain="PFOR_II (E-value: 9.9e-19, bitscore: 58.2, seeds: 27, tool: rule-based-clusters)" /sec_met_domain="POR_N (E-value: 1.4e-82, bitscore: 267.4, seeds: 31, tool: rule-based-clusters)" /sec_met_domain="POR (E-value: 1.6e-31, bitscore: 100.3, seeds: 86, tool: rule-based-clusters)" /sec_met_domain="TPP_enzyme_C (E-value: 2.9e-12, bitscore: 37.2, seeds: 323, tool: rule-based-clusters)" /sec_met_domain="Fer4_16 (E-value: 5.1e-12, bitscore: 37.2, seeds: 227, tool: rule-based-clusters)" /sec_met_domain="Fer4 (E-value: 9.2e-08, bitscore: 22.4, seeds: 528, tool: rule-based-clusters)" /sec_met_domain="Fer4_4 (E-value: 5e-05, bitscore: 14.4, seeds: 79, tool: rule-based-clusters)" /sec_met_domain="EKR (E-value: 2.4e-25, bitscore: 78.8, seeds: 127, tool: rule-based-clusters)" /transl_table=11 /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW RYNSYKRLARENWGADTAE" CDS 6727..6915 /locus_tag="ctg53_4" /transl_table=11 /translation="MIGFVIWIVGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG LLFYYFYGKERMAGWLK" CDS complement(6926..7759) /locus_tag="ctg53_5" /transl_table=11 /translation="MFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMTNLAKAIFED QGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVIGDIYDGARI GLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLDYKLMTSSGP AMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNAETIHTIAWKGFSEK DPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSWIPKKD" CDS complement(7814..8563) /gene_functions="biosynthetic-additional (rule-based-clusters) BPD_transp_1" /gene_functions="transport (smcogs) SMCOG1004:Binding-protein-dependent transport system inner membrane component (Score: 92.1; E-value: 1.2e-28)" /gene_kind="transport" /locus_tag="ctg53_6" /sec_met_domain="BPD_transp_1 (E-value: 4.2e-29, bitscore: 92.1, seeds: 81, tool: rule-based-clusters)" /transl_table=11 /translation="MGIGGFIDGFQHVLFGIPFYITIAVLAALAWFKSGKGTAVFTLLG LLLIYGMGFWEETMQTLALVLSSTCLALLLGVPLGIWTANSDRCNKIMRPVLDFMQTMP AFVYLIPAVLFFGLGTVPGAFATIIFAMPPVVRLTGLGIRQVPKNVVEASRSFGATPWQ LLYKVQLPLALPTILTGINQTIMMSLSMVVIAAMISAGGLGEIVLKGITQMKIGLGFEG GIAVVILAIVLDRITQGMADNRKSKKK" CDS complement(8641..9867) /locus_tag="ctg53_7" /transl_table=11 /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKEEREKKAMESMQLVGLKGYENQMVSE LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN EIIQNAIEL" CDS 10341..11627 /locus_tag="ctg53_8" /transl_table=11 /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM PFFYSRRNLYMIGFLLAFIVTLLEFMRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFVAIFTLPQQFTQQQKCRMFLFL LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC YPHVWRNFGYAVAMGIVLLTLPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP IAAWTLPHFRALQIGMLGLLTLLFLGNFHKWSSFAFRAQALGILMGWVVLLSDSAEKHT YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW VFFIVWIRMIWLTFLASFIHPRATNVLSD" CDS complement(11590..11922) /locus_tag="ctg53_9" /transl_table=11 /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH LWHVDE" CDS complement(11950..14523) /gene_functions="biosynthetic-additional (rule-based-clusters) Peripla_BP_1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1042:Periplasmic binding proteins and sugar binding domain of LacI family (Score: 59.4; E-value: 1.3e-18)" /gene_kind="biosynthetic-additional" /locus_tag="ctg53_10" /sec_met_domain="Peripla_BP_1 (E-value: 4.5e-19, bitscore: 59.4, seeds: 6, tool: rule-based-clusters)" /transl_table=11 /translation="VEIRSAGDDNTKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEEA YQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGSTP AMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIAP GAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDIL EKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVVL YGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQL EEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLRL VNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHTL ADMEKLERIYFNLLSNAFKFTPENGRIAVRLSSLCKEDKRWIRFTVANTGSMISAEHIR NVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGTISVESDEKQGTVFTVELPVQSCEAVA AEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKSSVLIIDDNEDIRSYVHTLLHTDYTV IEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSLD EQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKD FVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAA SLLASSDMTVAEIGYEVGFSSPSYFTKCYKEQFGESPTDFLKRKG" CDS complement(15036..16262) /locus_tag="ctg53_11" /transl_table=11 /translation="MFFSLIVPLFLSLFYKPIAYLCGRSLNNKSKRENYFMKHISNFLR SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG KLEKEWDEN" ORIGIN 1 gttcaagctg ataaggacta aaggtcatgt cactcttttt catcttttat tcattttagt 61 tgatacttat agtagtcaac caaatccagg gtaagacaac tactgttgat ttgattgact 121 taaccgcatg ttccaatcac attgaacgca tcagctactt caatagtact gctctctctg 181 aaaacattaa atcatatatc agtcaataat acataaatta tcagtcctta atacttgatt 241 tctcaattat taatatctga gaaatcaaac gttaacagtt gagatatcag atattaacat 301 cctgtaaatc aaagaataac acagtaaaaa cggtatttat caggacgatg cagagtgaga 361 gcaagtcctt gctctcactc tgctaccact ggatctctaa cagctaaaac atcgatgaat 421 aaagggatac agacgaactg ttagagcatg agagcaaaag cactatcttt ttcactgggg 481 gagagtaagc aaaagaaacg cacgataccg gctttgaggc gtcaccggta ctaacggcaa 541 atatccggca cacacccgat tattctctac ggacaaaggg aacgaagccg acatctgccg 601 atgttcctcc aaagcctgac cggctaaagg ataataatca atccgaaaag ctccttccgc 661 atccgcagcc aaataacgat ccgtcaagag ccatgccacc acccccatat tcattcgcag 721 attaatttcg acacaaggat gaatccggta aacaggcgct tcatccggaa aatgacaaat 781 catcatatcc actcccaagt atccatgata aaagccaccg aacaaagctg acaattcttc 841 ttccaaacga gtccgcagcc tgataaattc ttcttgtggc acataagccg atagtttctg 901 cagaatcttc tcgtcagaca gcaagtcatt ccctgcatac atcccactcc cacccgtgtg 961 gaagaccgaa tatccggcaa aaacaaccct tcctctcccg tcagcataaa actccatagc 1021 gaaatcttcc accttattat atataggttc gcctaccacc ccaccctgag aagcagcgac 1081 acgggcacac caaccggaaa taaaagtagt aaatatgcct ttacaccaat tcaatccttt 1141 cccgcttccg gaaagcggag cttttaacaa gcacgcttcc cgcccttcga cgaacgcact 1201 gcactccgcc aaagtactca aataaaaaga ttctccacag aagtattcat tcaaccgcaa 1261 cccaggcaac aactttaccg cctgcagacg atgcgaatgc tctctcagaa tattcatata 1321 atccgcagaa ggcagctccg tctgatctgc ccccaatgtc atcaaacgct tccgcaaagc 1381 agggtcccac ccccacggag agaacttccg gtctttaccg tcagccactt ccggttccgt 1441 caacaaggcc acatccatgc ccaaaagttc actctttgtt ttcaggaagt ccgcattata 1501 agcagacggt gcaagcaccg cacttcccgc ttcggcatac cacataggaa gcaacgccag 1561 gtcactcgcc atctgtcggg cggaagccgg cgccatatag ttcgtctcac cgcttgccaa 1621 cgccatatca tgctccggat tgaatatata aacaggtctt ttcgtcatgt caaagatgga 1681 ttcaacacat tattctgcaa atatatacag gaaataatca ggaacttaca caataaagag 1741 aaacttataa attaaagcac atttttgcta tctctacttt gcaaatccta aaaaaagcac 1801 tatatttgcc agccgaaaaa caaagaaacg aaatggaatc attctatcgc acacacgcct 1861 acctcgttga gcacaccaat gcccccgttc gccgcgatct tatggacgag atcgactgga 1921 gtgaccgtct gattggtatc aaagggacac gtggcgtagg aaaaaccact ttcctcctgc 1981 agtacgccaa agagaaattc ggcaccgacc gttcctgtct gttcatcaat atgaacaact 2041 tttatttctc cggtcacagc cttgttgact tcgccaacga gtttcagaaa cgtggcggaa 2101 aagtactgct gatcgaccag gtgttcaaac atcccgaatg gagcaaagag ctacgaatgt 2161 gctatgaccg tttccccagc ctgaagattg tcttcaccgg ttcttccgtc atgcgactca 2221 aagaggaaaa cctcgaattg cgtgacattg cgaaaagtta taacctgcgc ggattctctt 2281 tccgtgaatt tctgaacctg cagacaggaa tgaaattccg ggcatacagc ctcgaagaaa 2341 tcctcagtac acatgaacag atagccaaag gagtactttc caaagtacga ccgctggatt 2401 attttcagga ttacctgcat catggtttct accctttctt ccttgaaaaa cgtaatttct 2461 cggagaatct gctgaaaaca atgaacatga tggtagaagt ggatatcttg ctgatcaaac 2521 aaattgagct gaaatatctt tcaaagataa aaaaattact atatttgttg gctgtggacg 2581 gaccgaaagc tccgaacgtg agccaactgg caagtgacgt acagacatcc cgcgctacgg 2641 taatgaacta tatcaagtat ctggcagacg cgcgtctgat taatctggtt tacccgaaag 2701 gagaagaatt cccaaagaaa ccgtcaaaga ttatgatgca caactctaac ctgatgtact 2761 ccatttatcc ggtgaaagtg gaagaacagg atgtactcga cacgttcttc gttaacactt 2821 tatggaaaga ccataaggta cataaaggag ataaaaacgt ctctttcatg gtagacgaag 2881 tgatgccgtt caaaatttgt gcggaaggta caaaaataaa gaataacccg gacgtgacgt 2941 atgcgttgca aaaggctgag ataggccgcg gcaaccaaat acctctttgg atgttcggat 3001 tcttatacta aaaagattta tttacttaaa tatttaattt agttatgact aaacagaaga 3061 aattcatcac atgtgatggt aaccaagctg cagcacatat ctcgtatatg ttctctgaag 3121 tagcagctat ctaccccatc actccttctt cgactatggc tgagtacgta gacgaatggg 3181 ctgccgcagg acgtaagaac atcttcggcg aaacagtatt ggtacaggaa atgcaatctg 3241 aaggtggtgc tgccggtgca gttcacggtt ctcttcaggc tggtgcattg actactactt 3301 acactgcttc tcagggtctt cttttgatga tccctaacat gtacaagatt gccggtgaat 3361 tcttgccttg tgtattccac gtttctgctc gtacactggc ttctcacgca ttgtgtatct 3421 tcggtgacca tcaggacgta atgtcagctc gtcaaaccgg cttcgctatg ttggcagaag 3481 gttctgtaca ggaagttatg gatttggcag gtgttgctca tctggctact atcaaatcac 3541 gcgttccgtt catgaacttc ttcgatggtt tccgtacttc tcacgaaatc cagaagatcg 3601 aaatgttgga aaacgacgac ctcgctccgc tgatcgacca ggaagctttg gctgaattcc 3661 gtgcccgtgc actgaatccg atgaagccgg ttgcccgtgg tatggctgaa aaccccgacc 3721 acttcttcca acatcgtgaa tcatgcaata actactatga agcagttcct gctatcgtag 3781 aagaatacat gaacgaaatt tccaagatca caggccgcaa atacggtttg ttcgattact 3841 acggtgcaga agatgcagaa cgcgtaatta tcgcaatggg ttctgtaact gaagctgccc 3901 gcgaagctat cgaccacttg gtagcaaacg gcgaaaaagt aggtatggtt gccgtacact 3961 tgtatcgtcc gttctctgct aaacacttcc tggctgctgt acccaagact gcaaagagca 4021 tcgcagtgct tgaccgtaca aaagaaccgg gtgctaacgg cgaacctctt taccttgacg 4081 ttaaagactg cttctatggc gcagaaaatg ctcctgttat cgttggcggt cgctacggtc 4141 tgggttcaaa agataccact ccggcacaga tcatctctgt attcgaaaac ttggctatgc 4201 caatgccgaa gaaccacttc actatcggta tcgtagacga cgttacgttc acttctcttc 4261 ctcagaaaga agaaatcgct ctgggcggtg aaggtatgtt cgaagctaaa ttctacggtc 4321 tgggtgctga cggtacagta ggtgccaaca agaactctgt taagattatc ggtgacaaca 4381 ccgacaaaca ctgtcaggct tacttctctt acgactccaa gaagtcgggt ggtttcactt 4441 gttctcacct gcgtttcggt gatactccga tccgttctac ttacttggta aatactccga 4501 acttcgttgc ttgtcacgtt caggcttacc tgcacatgta cgatgtaaca cgtggtttgc 4561 gtaagaacgg ttctttcttg ctgaacacca tctgggaagg cgaagaactg gctaagaacc 4621 tgcctaacaa ggtgaagaaa tactttgcac agaacaacat ctctgtatac tatatcaacg 4681 caactcagat tgcaatggaa attggtctgg gcaaccgtac caatacaatc cttcagtctg 4741 cattcttccg tatcacaggc gttattcctg tagatcaagc tgttgaacag atgaagaaat 4801 tcatcgttaa gtcttacggc aagaagggtg aagacgttgt taacaagaac tacgctgctg 4861 tagaccgcgg tggtgaatac aagactctga ctgtcgatcc tgcttgggct aacctgccgg 4921 atgatgcaaa agcagaaaac aatgatcctg ctttcatcaa cgaagtagtt cgtccgatca 4981 atgcacagga cggtgacttg ctgccggtat ctgcattcaa gggtatcgaa gacggtactt 5041 ggtatcaagg tacttccaaa tacgaaaaac gtggtgtagc tgcattcgtt cccgaatgga 5101 atgctgaaaa ctgtattcag tgtaacaagt gtgcttacgt ttgtcctcac gcttctatcc 5161 gtccgttcgt actcgatgct gaagagcaga agggtgctaa gttcgagcaa ctgaaagctg 5221 taggtaaagc attcgatggt atgacattcc gtattcaggt agacgttctc gactgtctgg 5281 gttgcggtaa ctgtgccgac atctgtccgg gtaatccgaa gaagggtggc aaggcattga 5341 ccatgaaaca ccttgaaagc cagttggccg aagctgataa ctggacttac tgcgctgaaa 5401 acgtgaagag caaacaacac ctggtagaca tcaaggctaa cgtgaagaac tctcagttcg 5461 caactccgtt gtttgagttc tcaggcgctt gctccggttg tggtgaaact ccgtacgtga 5521 aactgatttc tcagttgttc ggtgaccgtg aaatggttgc taacgctaca ggatgttctt 5581 ctatctactc aggttcagtt ccttctactc cgtacactat gaacgaaaag ggtcacggtc 5641 ctgcatgggc taactccttg ttcgaagact tctgtgaatt tggtctgggt atggaactgg 5701 ctaacgaaaa aatgcgtgcc cgtctggtga aagtaatgaa cgaagctatc gcttctgatt 5761 gctgcccagc tgaatacaaa gaagtattcg ctgaatggat caacaatatg ctggatgcag 5821 aaaagactaa ggaactggct gaaaagatca ttccgatggt agaagctgct aaagataaat 5881 gcaaccactg caagcaaatc gctgatctgc aacaatatct tgttaaacgt agccaatgga 5941 tcatcggtgg tgacggtgct tcttacgata tcggttacgg tggtcttgac catgtaatcg 6001 cttccggtaa ggacgttaac atccttgtat tggatactga ggtttactct aacacaggtg 6061 gtcagtcttc taaagctact ccggtaggcg ctatcgctaa gtttgctgct gcaggtaagc 6121 gtgtacgtaa gaaagacctc ggtctgatgg ctactactta cggttatgta tatgttgctc 6181 agattgctat gggtgctgac caggctcaga ctctgaaagc catccgcgaa gctgaagcat 6241 atccgggacc atcactgatc atcgcttacg ctccatgtat caaccacggt ctgaaagccg 6301 gtatgggtaa gagccaggaa gaagaagaaa aggctgttaa gtgcggttac tggcacttgt 6361 ggcgttacaa ccctgctttg gaagaagaag gcaagaatcc gttccagctg gatagcaaag 6421 aacctaactg ggaagacttc caaggtttct tgaagggtga agttcgttac gcttctgtaa 6481 tgaaacaata ccctgctgaa gctgaagaac tgtttaaagc tgctgaagaa aacgctaaat 6541 ggcgttacaa cagctacaaa cgtcttgcca gagaaaactg gggagctgat acagctgaat 6601 aataagtaga aatactttgt acataataaa aggcaggaat cctggaaaca gattcctgcc 6661 ttttttgttt atatattaga agtaacgatt acttctcacg aagatattca ttaaaactct 6721 aaagatatga tcggatttgt tatttggatt gtcggtttga tactgacttt cagagctgcc 6781 atagagattt ggaatataaa tgcggctgta gagaaaaggc ttatagcgat tgtattaatc 6841 gttcttacca gctggctggg actacttttc tactacttct atggtaaaga aagaatggcg 6901 ggatggttga agtagtgttt gcttatcaat ctttcttagg aatccaactg tttaccagtt 6961 cctgatgttc ttccatccat tgacgggcag cctgtctttc cgtcgtctgc gcctcttcca 7021 gagcagtcat taaagagctg atttccgcat cagtcagacg aatattgccc agaagttcgg 7081 cagcaaaagg atctttctcg ctaaaacctt tccacgctat ggtatgaatg gtttccgcat 7141 ttccatatat cagcttcggg tcctgaagaa ctttcagttt gaaacggtcg aacatccagt 7201 gaggcgtcca tcccgtcacg acaatccagt ctttcttatc aatcgctttc tttagggaag 7261 cagtcatggc aggtccgctc gaagtcatca gtttataatc caatccatag tctttgatgg 7321 cctgatcggt agctttcata ataccggctc cggcatcaat accgacaatc tgaccggaga 7381 aacgttcctt ttccgcgttc agttcttcga tcgagttgat cgtaacgtaa tccggaacca 7441 ccagcccgat acgggcacca tcataaatat ccccgataac ttcgagttta tccccgtatt 7501 gtttcatata atcttccata gtgacaggca tccagacatc cataaatacg tctgctttct 7561 tacgggagat agaggtaaat ataggtgcaa ggtcggcatt cagcaacttt acatcgtatc 7621 cctgatcttc aaaaatcgct ttggcaaggt ttgtcatggc aatcccttcc gaccagttgg 7681 cataagcgat acttatcttc ttactctttc cgttgtctcc gcaggaaacg aaggttaaga 7741 gtatgccggc aataaacatt gccgcaatca tttttatctt attcattgat tattcctttc 7801 tttggtgtga ttcttatttc tttttacttt ttctgttatc tgccatgccc tgagtgatgc 7861 ggtccagcac gatcgccaat atcacgactg cgataccgcc ttcaaatccg agtccgattt 7921 tcatttgggt gatacctttc agcacgattt ctcccaatcc tccggcagaa atcatggcgg 7981 caatcactac catcgaaagt gacatcatga tcgtctggtt gattcccgtc agaatagtag 8041 gcaacgccaa aggcaattgt accttataaa gaagctgcca gggagtagct ccaaaagagc 8101 gggaggcttc tactacgttt ttaggaacct gacgaatgcc caggccggtc agacgaacca 8161 caggaggcat tgcaaagatg atggtggcaa aagctcccgg cacagttccc aatccgaaga 8221 atagaacggc aggaatcaga tagacaaagg caggcattgt ctgcataaag tcgaggacag 8281 ggcgcattat cttgttacaa cgatcactgt tggcagtcca gattcccagc ggaacgccta 8341 aaagcaatgc cagacaagtg gaagaaagta ctaacgccaa tgtctgcatc gtttcttccc 8401 aaaagcccat gccgtaaata agcaataagc ccaagagggt aaatacggct gtccccttac 8461 ccgacttaaa ccaggcgagc gcagccagca ctgcaattgt gatataaaaa ggtattccaa 8521 acagtacgtg ctgaaaaccg tctatgaatc ctccgatccc catgctgaga gcatcaaaaa 8581 aggaagcaaa atgttctgtg agccaattaa tggcagtttc tatatattgt ccgatattta 8641 tcataattct attgcgtttt gaatgatttc attaatttct tctttatctt ttcccgttac 8701 ttcgatgatc aatgaggaaa gtggcactac gccttcaaac tcccgattct catttacgac 8761 ccagattggc gagttcgttt ttgtcatcaa cggaagaata tcttccagca ccgtatcacc 8821 cagcactgaa tgaacttcat gccttactac ggactcgatg gagcggattt gctcttttcg 8881 tagtttcagc aagtcattca accgcacctc tcctactaac agattattgg aatcgactac 8941 cggaagaacg gtcagattcc gttcgcgcat cttacggatc agcacctccg ggccttcttt 9001 cttcaaacgt gccactatgg gtttatctac cataacagag gaagctgtta taatcttgct 9061 tcgatctaca ttctccacaa atcgttctac ataagcgttg gcaggttcgg tcaggatttc 9121 ttccgatgta ccgatttgta caatttctcc atccttcatg atagcaatcc ggtcacccaa 9181 tttaatcgct tcactcaggt cgtgagtaat aaagacaatc gtttttttca tcttcgactg 9241 caaagtcagc agttcatcct gcatctgcac acggatcaaa ggatcgagtg ccgagaaggc 9301 ctcatccatc aacaggactt cgggattatt ggccaaagcc cgcgccagcc cgacacgctg 9361 ctgcatccca cccgacagtt cacttaccat ctgattctcg tagcctttca gccccaccag 9421 ttgcatactt tccatcgctt tcttctcccg ttcttccttt ttaactccct gtagttcgag 9481 tccgaaagct atattatgca agacagaacg gtgaggaagc agaccgaagt tctgaaagac 9541 catagccagt tctttccggc gaatctgcaa cagttcttta tccgacactt tggctatgtc 9601 tgttccattg ataatcactt ctccggaagt agggcgtatc aaacggttga tgcagcggag 9661 taaagtggac tttccactac cggacaaccc cataatgacg aatatttcgc cttcattaat 9721 ggaaagattc gcatctttca ccgcaaccgt acatccggtc gctttcaata tttcactttt 9781 agttttacct tctttcaaca tcttcaaagc cttctgcttc tcattgccaa aaaccagata 9841 gagatcttta atttctattt tactcataca ataaaatggt ttaggttatt aaaataatat 9901 acacagcaag acaagaacaa acgataacag gaatctttct ttatatcgta taaagttctg 9961 atttaaatac gggacaaata acaatgaatc ccgaaataat taataaaatg attattgaca 10021 gactgagtaa ttaaaaaagg aatagaattt gataagataa tcctttcaac gaatagcaaa 10081 aaaatagcat ttttatgtat aaaaacagtc tgttccagta tcttgctggc acaaagatac 10141 aaaaaacaga ttaaacatgc aaattatatt caaaatccgg ggcatacaga ggactttatt 10201 tgtaatgata tggaaagttt ccgggtaata ttcccctatc actcagcaaa atagaacaaa 10261 ccagcagata aatataaaat aagtttgaat atttcaccta aacaccgtat atttggcgtc 10321 aataactaaa ctagatttat atgttcaaca gggctattac aattttcctg gggaaggata 10381 attgtcatta cacaacaaaa gaaaaacaaa caggtactgc cacactagac gacaaaagcc 10441 aagtacagtt ccttagtaaa aagaacccca aaatgccgtt tttctatagt cggcggaatc 10501 tctacatgat aggtttcctg ctcgctttta tagtgactct gctcgaattt atgcgaggac 10561 ggcatcaaaa ctttatggtc ttctcagacg ctactcaatt cttctggcaa ggcatcagcc 10621 catacacaac cgaatttgta gaagctcacg gacgctactt cctttattct cctgttttca 10681 cggtattgtt cgctccgttt gcgtatctgc ctgcatggct gggacctttc gcgtggaatc 10741 tattcaatta ttcattgttc tttgtggcga tcttcacgct gccccaacaa ttcacccagc 10801 aacagaaatg ccgtatgttc ctttttctgt tactgatttt aggacaaagt ttactttcat 10861 ttcagtataa cataacggta gcctatttat tcttattcgc ctatacgtta ttggaaaaag 10921 accgtggatt tctggctgtt ctgttaatca tgatttcggg atgtaccaaa gtatatggaa 10981 ttttcgaact ggcattgttg ctgtgctatc ctcacgtatg gcgtaacttt ggctatgccg 11041 ttgcaatggg cattgtattg cttacgttac cgttaatcaa aatagctcct gcagatttgc 11101 tcccctatta tgaagaatgg tgccatagtc ttgctgttca tcaatccgcc ggagcttatg 11161 attcattttt ctatgcccgc cccattgcag catggacatt gccacacttc cgtgcacttc 11221 agataggaat gctcggtcta ctgactctgc tctttttggg gaatttccac aaatggtcgt 11281 cttttgcctt ccgtgcccaa gctttgggca ttctcatggg ctgggtagta ttactgagtg 11341 actccgccga gaaacatacc tatattatcg cattggcagg tttcatgctc tggtattgga 11401 gcaggccaac acgtaccgca acagacaaga ttctattttg gtgctgtttt gtgctgttat 11461 gcatcgttcc tatcgacata ttcgtccctg ttcccatcag agatttcatt accaggacct 11521 tatggcttca tgtatgggtt ttctttattg tatggatacg gatgatatgg cttaccttcc 11581 ttgcatcctt cattcatcca cgtgccacaa atgttctttc agattaacgc atccgttagc 11641 tttgaaagaa acttcttctg ccagcaagag ttgtttttgt tccacccaac cgggtaccag 11701 ccttccggtg gaatttacaa ctctatggca aggaatggat aattcatccg gcacttcttt 11761 caatgcacgc cccaccatcc gcgaacattg gggggcaccc aaaagcaaag caatacctcc 11821 ataggtagat acttttccca caggtatctg ggatacgact tcgtacactt ccttccgaaa 11881 ggattcggaa aaactctctt tatctacttt ataatctttc atatatccct ctttacgatc 11941 tcaatgaaat catcctttcc ttttcaggaa gtctgtcggg ctctctccga actgctcttt 12001 atagcacttg gtgaaataag aaggtgaact gaaaccgact tcataaccaa tctccgctac 12061 ggtcatgtcc gaagaagcaa gcaaagaagc tgccttcttc aaacgggcga tacggagcaa 12121 ttcattcgga gagtagttag tcaacgattt aatcttgcgg taaagctgca cacggcttag 12181 tcccatatcc ttgcccaagt cctccacatt caaaccggag tctcccattt tctcttcaat 12241 caatgacttg aatctttcta caaaatcctt gtccatatcg caaacatctt ccttcgccaa 12301 tgtctgcccg tcaccaaaga actgtttcag acgacggtga gaatcgatca ggttgcggac 12361 acgtgccagc aacagttgtg aactgaacgg ctttgaaata taagaatcgg caccaccgtc 12421 atatccctga atacgctgtt cgtccagtga acacgccgtc agcagaataa ccggaatatg 12481 acaggtctgt aactcacttt tcagccggcg gcaacattca atgccatcaa tgcccggcat 12541 catcacatcg gaaataatca ggtcaggaac atacttcata gccttacgga ttccttcgga 12601 gccgtctgcc gcttcaatca ccgtatagtc tgtatgcaac agcgtatgga catacgaacg 12661 gatatcctca ttatcatcaa taatcagtac ggacgatttg gaagagtcat atcctttttc 12721 cagttcttcc tcttccgcca atagaacatc tgttgtacgg gaatccgcag aaacaagggt 12781 ggtatccggt tcggcagcaa cagcctcgca agactgtaca ggcagttcaa cggtaaagac 12841 cgtaccctgt ttctcatcgc tctctacaga gatcgtacca ccatgcattt ctacgaaggc 12901 ttttaccaat gccagtccga ttcccgaacc ggtatggtgc atatcgatct tatagaaacg 12961 gtcgaataca ttgcggatat gttcggcaga aatcatagaa ccggtatttg ccaccgtgaa 13021 acgtatccat cgcttgtcct ctttacaaag ggaagacaga cgaacggcaa ttcttccatt 13081 ttccggtgta aacttaaagg cattggacag gagattgaaa taaatacgtt ccagcttctc 13141 catgtctgcc agtgtatgat aatccgtatc cggcatacta tcaaaagaaa aatggatatg 13201 cttcttacgg gctgccgcct gaaaagactc attccatcct tcgaaagaag aaaggacatc 13261 caccgtaacc ggagtatatt ccatcttgcc attttcatat ttacggaaat ccagaatctg 13321 attgaccaga cgcagaagaa tgttcacatt ccgctgaatc agcatgagca tccggtgctg 13381 atctccgctc agtgtcttgt ccgccaacaa atgttctacc ggatcggcaa ccaatgtcaa 13441 cggagtacgg aagtcgtgag aaatattggt gaagaatacc agcttggcat gagtagcttc 13501 ttccagttga tgagaaagtt gtatcaattg gtcacgctgt tcttccagtt tgtcacgttg 13561 ctcttccaat tgttgcttct gcttaaaaag ttctttattc aagcgattct ttgagcggag 13621 tgatttataa acgaccaata ataagccggc taccaataaa aggataatca gactgccgta 13681 taaaacgacc tgttgtgtag ctacctgaga gagatagcca ccgatacgtc cgttgagcgt 13741 ttcaatcttt ttgtcgagtt cggaaatgtg tgtggtctgc aactgcatga cgtgtgcgtt 13801 ggtacggtcc acaacagcgg tattcatcac cgtttctttg ggatagggtt tcttctccag 13861 aatatccata gccagttgca gtaccttatc accattggtc ggatagataa aggtagcatc 13921 cagcacactg tccagaacca gctccagccc gtttccctta cccggcaagg catctatgcc 13981 gacaaaaatc atttccttct cccgccctgc catctttgct gcctgatagg cacccggagc 14041 gatacgatca ttatgggcat acacagcatc aatcttagga tgcctccgaa gcatactatc 14101 catttctatc tctgccggac cacgttccca agcagcatcc gctttatcaa tcagctttat 14161 atccgggaat ttactgatgg cagccataaa tccctgatgc cgttccattg caggagtcga 14221 accgctcaat cctgtcagtt ctactatatt tcccttccct ttcagactgg aggcaatata 14281 gtttcctacc gaacgaccga tttcataatt atcggctccg atataggcag tatatttatc 14341 cgaaagaatc ttccggtcta caagaataac ggggatgcct ttctgataag cttcttctac 14401 aatcggagtc ataggagcag cttcgttagc ggaaataatc agcagatcga ctccttcgtc 14461 cataaaataa tggacatctt ccgcctgctt agtgttatca tcccctgccg aacggatttc 14521 caccgaaaca ccattataaa acatcgcttc ccgaagaatc tcatcattca tcttatgtcg 14581 ccatgaatca tcgctgcatt gagccacccc aatacgaaaa cggggtgtat cctgccggca 14641 agccgtcatc ccggttaaac aaaacagcac cagcatccac ttcagatatc tcatcgtctt 14701 catccatctc atcatttcgt agttctttct gtaatccaat taagaacaaa aataagaaat 14761 aatactgtaa agttctctaa cttcagctat ttattattct aaaaagaagg aaagcagtcc 14821 tctttcagac catcggaaag tattaacaaa agtataaagc gtaaaacaaa cacttaatca 14881 atgttataaa acatagcgtt ttacttggat aatttgcaga tttcacagaa gtccgtatct 14941 ttgtactgtg tttttcatag tattagattt aaggttaaca aaggttggag caaggcgttg 15001 ctcctttttt tatgccctga cctttcatct accggttagt tttcatccca ttccttttcc 15061 agtttaccat caatagtgta gcgtttccat cgtcctacac ggcgaccatt cttatattcc 15121 ccacattcac gaagctggtc attctttaca taacgagctt cgaacggtcc gttctgcctt 15181 ccgttcacat aggtagaagt ttcccaataa tcaaagcggt tgctcactat cagccgtcgt 15241 tccttgccat gcaatctgcc ggcctgatag gtagcttcat atctcaattc accattttcc 15301 aaattatatt cacggtataa accgtcttta cgatcgttct tcatataata ttctttctgc 15361 cttaccccac ttccgttggc aaatgagaca tggagtccat cttcttttcc atccagatag 15421 gtttcaatca tcagcgtatc gccgctttca gcaaaagtag tccaacgacc attcttcttt 15481 ccattcttat aactacccag tatacgtggc gagccaaacg taaacacgga cgaatattca 15541 ccgtcctgaa aaccttcttc attgaaataa acggtctcat acaaatcata tgtacctttc 15601 agaaaagtat actgtttgcc tacctgcttc ccgtccttgt aattatgctc tttccgcaaa 15661 gtaccgtcag attcgtacga cagttgcttc ccgtgctctt tccccatccg gaagtttctt 15721 tcactttcca cttttccggt agtaaagtaa cttttgctcg taccgtccag cttaccttcc 15781 ttataggact tttcttcttt cagcttaccg tcaaacttgg agttaatctt gaagagacca 15841 tccttccgtc cttctttata acttccttct gttattaata tattgtctac atattctttg 15901 tatccgccat catagaaacc atctttaaaa gatgccagca cataggcgga atgataacca 15961 tctatgatgc gatgttcgcc attcaatgct ttttccgttt tcagttcctg aaacaacagt 16021 ctgccatcgc ctacattgac aacggatacc tgatcgatct tatattcctt ttgcgcaaac 16081 aaaggaagag caagatataa aaacaaaaat acgttccagc tttttgatct gaggaagttt 16141 gaaatgtgtt tcataaagta gttttctctt tttgatttat tatttaaaga cctgccgcaa 16201 agataggcaa tcggcttata aaacaaggaa agaaagaggg ggacaattag agaaaagaac 16261 atctgttatt atcattctaa taattaacag attaagtagt aaatcaaaac acagggaagg 16321 gggatattta ctgaaataag aaacagaaaa gaagatgtgt caaaagtaac taaatttccc 16381 tccttcagga aggaggggtg gctgaaagcc ggggtggtag gtatatttca cagttgaata 16441 tcaatagctt atgtattcac ctaccacctc cccctacgag tactcctcct tcccgaagga 16501 ggagagttta gttacttttg acacacctgc tttttgtatt taaagagatt ctacaacaat 16561 ctgtctttca gaacaaccgg aagttcgggc attgcaccgc tc //