LOCUS       c00356_gnlPro..        14793 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GCIPKHDH_356.
ACCESSION   c00356_gnlPro..
VERSION     c00356_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 09:48:25
            Original ID  :: gnl|Prokka|GCIPKHDH_356
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4481
            Orig. end    :: 19274
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14793
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[14481:18710]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14229
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14793
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14793
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(39..905)
                     /locus_tag="ctg356_4"
                     /transl_table=11
                     /translation="MIKEYTKQTIIICFLLQGIALSSRAQEQQMWQRYHDKCRREASII
                     DPLPSKLEKALHWSPTINKEQKEVIRYILWNMVYVEGGTANLGDNNNYPVDVASFFINR
                     YEVSQDEWYVIMGENPSNQHRRNYPVDQVNWFNAQRFTKKLSQLSGLPFRLPFEAEWEY
                     AAREGLKTKNFIYAGSNNAEQVAWFREKYYNTYVSKETGTKRPNELGLYDMSGNVYEWC
                     MDWYDRKVPFTGNIAPVICEKDTHKVLRGGSYYTFEKYCKVTSRYGVNPQRWDIDYGLR
                     LVVSLPD"
     CDS             1156..2214
                     /locus_tag="ctg356_5"
                     /transl_table=11
                     /translation="MKKKLAGVALVLAAVSLMSIQPVEACTRAVYIGPDQMVVTGRTMD
                     WKEDIMTNIYVFPRGIQRMGHNKEKTVNWTSKYGSVIATGYDIGTCDGMNEKGLVASLL
                     FLPESIYSLPGDTRPAMGISIWTQYVLDNFATVREAVDELKKETFRIDAPRMPNGGPES
                     TLHLAITDETGNTAVLEYLDGKLSIHEGKEYRVMTNSPRYEQQLAINDYWKEIGGLQML
                     PGTNRASDRFVRASFYIHAIPQIADAKIAVPSVLSVMRNVSVPFGINTPEKPYISSTRW
                     RSVSDQKNKVYYFESTLTPNLFWLDLKKIDFSPKAGIKKLSLTKGEIYAGDAVKDLKDS
                     QSFTFLFETPVM"
     CDS             complement(2325..3689)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg356_6"
                     /sec_met_domain="Peptidase_M20 (E-value: 2.8e-39, bitscore:
                     125.1, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIQKYIAAHEPKMMDDLFSLIRIPSISALPEHHDDMLACAERW
                     AQLLLEAGVDEALVMPSQGNPVVFAQKIVNPDAKTVLIYAHYDVMPAEPLELWKSEPFE
                     PEIRDGHIWARGADDDKGQSFIQVKAFEYLVKNGLLKNNVKFIFEGEEEIGSPSLEAFC
                     EEHKELLKADVILVSDTSMLGAELPSLTTGLRGLAYWEIEVTGPNRDLHSGHFGGAVAN
                     PINALCQIISKVTDADGRITVPGFYDDVEEVPQTEREMIAHIPFDEKKYKEAIGVKELF
                     GEKGYSTLERNSCRPSFDVCGIWGGYTGEGSKTVLPSKAYAKVSCRLVPHQDHHKISQM
                     FADYILSIAPDTVQVKVTPMHGGQGYVCPISLPAYQAAEKGFEIAFGKKPLAVRRGGSI
                     PIISTFEQVLGIKTVLMGFGLESNAIHSPNENCSLDIFRKGIEAVIEFHQEYARR"
     CDS             complement(3689..4765)
                     /locus_tag="ctg356_7"
                     /transl_table=11
                     /translation="MFNSFGNIFRLTSFGESHGKGIGGVIDGFPSGITIDEEFVQQELN
                     RRRPGQSILTTPRKEADKVEFLSGIFEGKSTGCPIGFIVWNENQHPNDYNNLKNVYRPS
                     HADYTYTVKYGIRDHRGGGRSSARETISRVVAGALAKLALRQLGVNITAYTSQVGPIKL
                     EGTYSDYNFDLIETNDVRCPDPEKAKEMADLIYKVKGEGDTIGGTLTCVIKGCPIGLGQ
                     PVFGKLHAALGNAMLSINAAKAFEYGEGFKGLKMKGSEQNDVFYNNNGRIETHTNHSGG
                     IQGGLSNGQDIYFRVVFKPIATLLMEQETVNIDGVDTTLKARGRHDACVLPRAVPIVEA
                     MAAMTILDYYLLDKTTQL"
     CDS             4927..5493
                     /locus_tag="ctg356_8"
                     /transl_table=11
                     /translation="MKKNLLYLWALVCSLTLFAACSSDDDDSDNKNNENPPEEEAVITA
                     PDVIGTYWGNLDMSMIPDGSDQEIVIGDGIEKFITLSQVSNTEVKIELKDFELFINQQI
                     LKFGDIVIDKCEVKKGEGMSTFTGQQDLTFEGDAASLGTCPVTVTGTVEGGNADMTINV
                     KVPALQQTVKVTYSGVKQVAEPSGT"
     CDS             complement(5490..6275)
                     /locus_tag="ctg356_9"
                     /transl_table=11
                     /translation="MKIYPYIFSLLTCIGIALPGYAQVDRNETLIRSALHGMEYEIKAG
                     FSIGGTAPLPLPVEIRSIDGYNPTLAISIGGEVTKWIAVQNKLGIIVGLRLENKAMTTE
                     ATVKNYNMEILGQGGERISGVWTGGVKTKVHTAGLTIPLMATYKLTNRWNIKAGPYFSY
                     LLSREFSGHVYEGYLREDNPTGPKVEFTDGKIATYDFSDDLRHFQWGLQIGAGWRAFKH
                     LNVYADLTWGLNDIFKNDFNTVTFAMYPIYLNIGFGYAF"
     CDS             complement(6308..7393)
                     /locus_tag="ctg356_10"
                     /transl_table=11
                     /translation="MKAKHVILYLLLAIVSFSCIGEEALNAEADILSCALPGVAMTTSP
                     IINNNSITIFVGPGTDISELTPEFTLTPGATINPLSGTERNFNTPQEYTVTAADGVWKK
                     TYIISVIDTELATNYNFEDTLGGKKYYIFVEREGGKVVMEWASGNAGYAMTGVAKTADD
                     YPTFQITDGKAGKCLSLVTRSTGFFGQIAGMPIAAGNLFIGSFDVSNAMSNPLKATKFG
                     LPFRHVPTYLAGYYKYKAGDQFTEGGKPVNGKRDICDIYAIMYETSESVPTLDGTNAFT
                     SPNLISTARINNAKETNEWTYFKLPFTTLPGKFIDKEKLMDGKYNIAIVFTSSLEGDHF
                     NGAIGSTLLIDEAELIYHSED"
     CDS             7527..8813
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg356_11"
                     /sec_met_domain="SDH_alpha (E-value: 2.7e-63, bitscore:
                     204.2, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESERRQIIELIKKEVIPAIGCTEPIAVALCVAKAAETLGVKPE
                     KIDVLLSANILKNAMGVGIPGTGMVGLPIAVALGALIGKSDYQLEVLRDCTPEAVEQGK
                     RFIAEKRICISLKEDITEKLYIEVICKARDKTAKAIIAGGHTTFIYIAKDEQTLLDKQH
                     TVSEEEEDASLELNLRKVYDFALTAPLDEIRFILDTARLNKAAAEQAFKGNYGHSLGKM
                     LRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGISATLPVVVFAE
                     ENGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGNYNQVA
                     FAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTSVEGIIDEDVDQ
                     SIRNLTRIGSQAMNETDKMVLDIMTHKGC"
     CDS             complement(8941..9519)
                     /locus_tag="ctg356_12"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTMEDGEKELFEEAKAEHPFQFISGLGTTL
                     EDFENQITALSKGDKFDLTIPADKAYGQYDEQHVIDLPKNIFEIDGKFDSERIKEGNIV
                     PLMTGDGQRVNASVVEIKPDIVVVDLNHPLAGADLIFEGEILESRPATNEEIQELVKMM
                     SGGDGCGCGCDSCGDGCGDDCGCEGGHCH"
     CDS             10001..11800
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg356_13"
                     /sec_met_domain="ILVD_EDD (E-value: 7.4e-217, bitscore:
                     711.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAREWNGQHLDLID
                     AMIKSADESVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTQLFKDAAELIVKNAKLYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAIAHEAEVDFKMDDIDMLSRKAPCLCKVAPNTQKYHIQDVNRAGGIIAIMDELAKGG
                     LIDTSVRRVDGMSLAEAINEYSITSPNVSEKAIKKYSSAAGNRFNLVLGSQGMYYKELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPARKINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRII"
     CDS             complement(11725..11874)
                     /locus_tag="ctg356_14"
                     /transl_table=11
                     /translation="MTVENEWFTIIALSAAQLTITYQLYYIILTAPLSAELTMLAYAFR
                     LFGT"
     CDS             11915..13609
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg356_15"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-47, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDLITGAEALMRSLEHQGVTTIFGYPGGSIMPVFDALYDHQNIL
                     NHILVRHEQGAAHAAQGYARVSGDVGVCLVTSGPGATNTVTGIADAMIDSTPIVVIAGQ
                     VGTGFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIARSGRPGPVVLDF
                     AKNAQVEKTKYEPTKVDFIRSYVPVPDTDEETVQAAAELINNAERPLVLVGQGVELGNA
                     QSELREFIEKADMPAGCTLLGLSALPTEHPLNKGMLGMHGNLGPNINTNKCDVLIAVGM
                     RFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDVAVLGDCKETLASVTKLLKKNTH
                     TEWIDSFKEYEKVEEEKVIRPELHPATNSLSMGEVVRAVSDATHHEAVLVTDVGQNQMI
                     SARYFKYTKERSIITSGGLGTMGFGLPAAIGATFGAPERTVCVFMGDGGLQMNIQELGT
                     IMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRAFT
                     REELKEAIAEMLATDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             13666..14229
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg356_16"
                     /sec_met_domain="ALS_ss_C (E-value: 8.4e-19, bitscore:
                     57.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITALTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKLIRRYNARVVEVNPVFSIVEKNGMSEDITSLYGELKALNCVLQFVRSGRVAITTS
                     CFERVNEFLDGREAMYNQSKNQQE"
     CDS             14229..14792
                     /locus_tag="ctg356_17"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEDFSVQTWVENVYRLFTDRNFAIIDKDGK
                     KIGYARSVWAMINLNTRKPADLLTLHGGSIVDYVCDEPCPIEKPSRIKVTSDQPMATLT
                     AKYSDIDINGHVNSIRYIEHILDLF"
ORIGIN
        1 aggagctaaa ataatacagt gaataatatg ctcctctttt aatctggcag tgacactacc
       61 agccgtaatc cataatcaat atcccatcgt tgcgggttaa ctccgtagcg gctggtgact
      121 ttacaatatt tctcgaaggt ataataacta cctccacgta acactttatg cgtatctttt
      181 tcgcatataa ccggagcgat gtttccggta aaaggaacct ttctgtcata ccagtccata
      241 caccattcat atacgtttcc actcatgtca taaagtccca gttcgttggg cctcttcgtc
      301 cctgtttctt tggacacgta agtattataa tatttttctc taaaccaggc aacctgttct
      361 gcattattgc tgccggcata gatgaaattc ttggttttta gtccctcacg tgctgcatat
      421 tcccattctg cttcgaaggg gagacggaag ggtagaccgc ttaattgaga aagttttttg
      481 gtaaaccgtt gagcgttgaa ccaattgact tggtctaccg gatagttacg tctgtgttgg
      541 ttagaaggat tttctcccat aatgacatac cattcatcct gactaacttc atatcggttg
      601 atgaaaaaag aggctacatc cacgggatag ttgttgttgt ctccgagatt ggctgtacca
      661 ccttccacat aaaccatatt ccatagtata tagcgtataa cctctttttg ttctttattt
      721 attgtcggcg accagtgcaa ggctttttcc aatttggagg ggagagggtc aataatactt
      781 gcttctcttc gacatttatc gtggtatcgt tgccacattt gttgttcttg cgctctgctt
      841 gataatgcga ttccttgtaa tagaaagcaa atgattatag tttgtttggt gtactctttt
      901 atcatgataa ttgtatgttt atttattgga cgaactaaag tagcaatgac tgcaatagta
      961 acacttaaat ttatttaata ttcttcgcta agaaatgatc tttgtgatga taaccctcat
     1021 acgttgaaaa cccaaaattt cttcctgcat tgaataaatg cctttttttc attaaaatcc
     1081 tctttctttt aggcaataat cgtggcgcgt ttgttattta taaataagaa gatcaattat
     1141 ttaaatagaa tgaacatgaa gaaaaaatta gcaggagttg cattggtgtt ggctgccgtc
     1201 tctttgatga gtatacagcc tgtagaagca tgtacgcgtg cagtgtatat aggccctgac
     1261 cagatggtgg taacaggacg tacaatggac tggaaggaag atatcatgac gaatatctat
     1321 gtatttccgc gtggcatcca acgtatggga cataacaaag agaaaactgt gaactggact
     1381 tccaaatatg gaagtgtgat tgctacagga tatgatatag gtacttgtga cggaatgaac
     1441 gagaaaggat tagtggctag cctgcttttc ttgccggaat ccatttactc tcttcccggc
     1501 gatacccgtc cggcaatggg catcagcatt tggacacagt atgtgcttga taactttgcc
     1561 acggtacgcg aagcggtgga tgaattgaaa aaggagactt tccgcattga tgctccccgt
     1621 atgccgaatg gaggaccgga gtctacctta catctggcca taaccgatga aacaggcaat
     1681 acggctgtat tggaatatct ggatgggaaa ttaagtattc acgaaggaaa agaataccgg
     1741 gtgatgacaa attctcctcg atatgaacag cagttggcca ttaatgatta ctggaaagaa
     1801 atcggtggct tacagatgtt acccggaacc aatcgggcaa gcgaccgttt tgtacgggct
     1861 tcattctaca ttcatgccat tccccaaatt gcggatgcaa agattgcagt tcccagcgta
     1921 ttgagtgtga tgcgtaatgt ttccgtgcca tttggtatta atacaccgga gaagccttat
     1981 atatcttcta cccgttggcg ttccgtatcc gatcagaaga ataaggtata ttatttcgaa
     2041 tctaccctga ctccgaattt gttttggctg gatttgaaga aaattgattt tagtccgaaa
     2101 gccggcatta agaaactgtc tctgacaaag ggcgaaattt atgcaggtga tgcagtgaag
     2161 gatttgaaag acagccaatc atttaccttc cttttcgaga ctccggtcat gtaatttgtc
     2221 agtgtgatag atatataaaa gagtggtgga caaatgcttg taatcaagct tgtccaccac
     2281 tcttttatat gtatcgttta taacttgatt gttatttatc cactttatcg tctggcatat
     2341 tcctgatgaa actctatgac tgcctctatc cctttccgga agatatccaa tgagcagttc
     2401 tcgttcggag aatggatcgc attcgattcg agtccaaatc ccatcaatac ggttttgatt
     2461 cccaatacct gttcgaaagt agagatgatg ggaatacttc cgccacggcg taccgccaac
     2521 ggctttttcc cgaaagcgat ctcgaaacct ttctctgctg cctgataggc aggaagtgaa
     2581 atcgggcaca catatccttg tcccccgtgc atgggagtca cttttacctg tactgtatca
     2641 ggcgcgatac taagaatata atctgcgaac atttgcgaaa tcttatggtg atcctgatgc
     2701 ggtactaacc ggcaagatac tttagcataa gcctttgaag gcagtacggt tttagaacct
     2761 tctcctgtat atccgcccca aatgccacat acgtcaaaag acggacggca actgttacgt
     2821 tccaatgtgc tatatccttt ttctccgaaa agctctttta caccgattgc ttctttgtat
     2881 ttcttttcgt caaaaggaat atgggctatc atttcccgtt cggtttgcgg cacttcttcc
     2941 acatcatcgt agaatccggg aacagtgata cgtccgtcgg catccgttac tttgctaata
     3001 atctggcaaa gcgcgttgat cggattggct accgcacccc cgaaatgtcc ggaatgcaag
     3061 tcacgattcg gtcccgtcac ttctatttcc caataagcca gcccgcgcag accagtagtc
     3121 aatgagggca gttcagctcc tagcatactc gtatccgaca ccagaataac gtctgctttc
     3181 agcaattctt tatgttcttc gcagaaagct tccagactgg gtgaacctat ttcttcttca
     3241 ccctcgaaga tgaacttcac attattcttc agtaatccgt ttttgacgag atattcaaat
     3301 gctttcacct gaatgaacga ttgtcctttg tcatcatccg ctccacgtgc ccagatatgt
     3361 ccgtcacgta tttccggttc aaacggttcg cttttccaga gttccaatgg ttcggccggc
     3421 atcacatcgt aatgagcgta gattaataca gtctttgcat ccgggttcac gatcttttga
     3481 gcgaaaacaa ccggattgcc ctgtgagggc attaccaatg cttcgtccac acctgcttcc
     3541 aataacagct gtgcccagcg ttccgcacaa gccagcatat cgtcgtggtg ctccggcaga
     3601 gcactgatac tgggaatgcg aataaggctg aacaagtcat ccatcatctt tggttcgtgt
     3661 gccgctatgt atttctgaat ctcgttcatt agagttgcgt cgttttatcc agtaagtaat
     3721 aatcgagtat agtcatggcg gccattgctt ctacgatagg tacggcacga ggtaatacac
     3781 aagcgtcatg acgtccgcgt gctttcagag tggtgtcgac gccatcaatg ttgacagttt
     3841 cctgttccat cagcagcgtg gcaatcggtt tgaacactac acggaaataa atatcctgac
     3901 cattactcaa tcctccctga atacctccgg agtgattggt gtgcgtctcg atccgtccgt
     3961 tattgttata gaaaacatcg ttctgttcgg aacctttcat tttcaaaccc ttgaatcctt
     4021 caccgtattc gaatgctttg gcagcgttga tgcttaacat ggcgttaccc agggcagcat
     4081 gaagtttacc gaaaacaggt tgtcccaatc cgatggggca tcccttaatg acacaggtca
     4141 gtgtacctcc gatggtatcg ccttcacctt ttaccttata tataaggtct gccatttctt
     4201 ttgctttttc agggtccgga caacgtacat cgttggtttc tatcaggtcg aaattatagt
     4261 ccgagtaagt accctcaagc ttgataggac ctacctgtga ggtataggca gtgatattga
     4321 ctcccagttg gcggagtgcc agcttagcca atgcaccggc tacaacgcgc gaaatcgttt
     4381 cgcgtgcaga ggaacgtccg ccgccgcgat ggtcacggat tccatacttc accgtgtatg
     4441 tgtaatcagc gtgtgaagga cgatatacat ttttcagatt gttgtagtca ttggggtgtt
     4501 ggttttcatt ccaaacgata aaaccgatag gacacccggt tgatttcccc tcaaaaatac
     4561 ctgaaagaaa ctctacttta tcagcttctt tgcgtggggt ggtaaggatt gattgtcccg
     4621 gacgacggcg atttagttct tgttgtacaa attcttcgtc gatggtaatt cctgatggga
     4681 atccgtcaat cactcctcca attccttttc catgagactc accgaaactt gtgagtcgaa
     4741 agatattgcc aaatgaatta aacatagttg tggctttttt aaaattacta tatgcaaata
     4801 taacaaagtt ttcggtaaga aagttgcgaa ctcgaaatta cttcgaaaaa ggaagcatat
     4861 tgaacctttt ttcttctttt tagtttataa aggacgaatt tattgtaata actaaaccaa
     4921 agacgtatga aaaagaatct attgtattta tgggcattgg tatgttctct tactctcttt
     4981 gctgcttgta gcagtgatga cgacgatagt gataacaaga ataatgagaa tcctcccgaa
     5041 gaggaagctg tgataacggc tccggatgta atcggaacgt attggggaaa tctggatatg
     5101 tccatgatac cggatggctc cgatcaggaa attgtcatcg gcgacggaat agagaagttt
     5161 atcacgcttt cgcaggtcag caatacggaa gtgaagattg aactgaagga ttttgaattg
     5221 ttcatcaacc agcagatatt aaaatttgga gatattgtca ttgataaatg tgaagtgaaa
     5281 aagggggaag gtatgtctac attcaccgga cagcaagatc ttacatttga aggagatgct
     5341 gcctctttgg gtacttgtcc tgtaacagtt acgggaactg tagaaggtgg aaatgcagac
     5401 atgactatta atgtgaaagt gcctgcattg caacagacgg tgaaagtaac ctactccgga
     5461 gtgaagcagg tggcagagcc tagtgggact taaaaagcat acccgaaacc tatattcaag
     5521 tagatggggt acatggcaaa agtgactgta ttaaaatcgt ttttaaatat atcattcaat
     5581 ccccaggtaa gatcggcata cacattgagg tgcttgaagg ctcgccatcc ggctcctatc
     5641 tgtaatcccc actggaaatg tctcaagtcg tccgagaaat cgtatgttgc aattttaccg
     5701 tcggtaaact caaccttcgg accggtggga ttatcttccc gcaaatatcc ttcgtatacg
     5761 tgacctgaaa attctcttga aagtagatag gagaaataag gcccggcttt gatgttccac
     5821 cggttggtta gtttgtaggt agccatcaga ggtattgtca gtccggcagt atgtactttg
     5881 gtttttactc cgcctgtcca tactccgctg attctttcac ctccctgccc gagaatctcc
     5941 atattgtaat tcttcacggt ggcttcggta gtcattgctt tgttttcaag tcgcaatccg
     6001 actataattc cgagcttgtt ctgaacggca atccatttgg tcacttcacc tcctatactg
     6061 atagctaatg tcgggttata tccgtcaatg gaacggattt ccaccggaag aggaagcggg
     6121 gctgtgccgc caatgctgaa acctgctttt atctcatatt ccattccgtg aagggcggaa
     6181 cggatcagtg tttcatttcg atcaacctgt gcatagccgg ggagggctat tcctatacag
     6241 gttagtaaac tgaatatata cggatagatt ttcatcgttt ttgttgttat aaagttattt
     6301 agttccacta atcttccgag tgatagatta actcggcctc gtcaatgagc aacgtacttc
     6361 cgattgctcc gttaaaatga tctccttcca gacttgaggt gaacactatg gctatattat
     6421 attttccatc cattagcttt tccttatcta tgaatttgcc ggggagagtg gtgaaaggaa
     6481 gcttaaagta agtccattcg ttcgtttctt tggcattatt aatccgtgct gttgaaatca
     6541 ggtttgggct ggtaaatgcg ttcgttccgt caagggttgg aacagattcg ctggtttcgt
     6601 acatgatggc atatatgtca cagatatccc gtttcccatt tacaggtttg cctccttctg
     6661 taaactgatc tcccgctttg tacttataat agccagccag ataagtaggt acatgccgga
     6721 aaggaagacc gaatttagtt gctttaagcg gattactcat tgcattgctt acatcaaagg
     6781 aaccgataaa cagatttcct gccgcgatag gcattcctgc tatttgtcca aagaatccgg
     6841 tactgcgtgt cactaaagaa aggcatttgc cggcttttcc gtccgttatt tggaaagtgg
     6901 gatagtcatc agcagttttg gctacgccgg tcatggcata gcccgcattt ccgctggccc
     6961 attccataac gactttacct ccttcgcgtt ctacaaatat gtagtacttc tttccgccaa
     7021 gcgtatcttc gaaattatag ttcgtggcaa gttccgtgtc gataacggat atgatatacg
     7081 ttttcttcca aacaccatcg gcagctgtaa cagtatattc ttgtggagta ttgaaatttc
     7141 gttccgtacc gctaagagga ttaattgtag ctcccggagt caatgtaaat tcaggtgtaa
     7201 gttctgaaat atcagttccc ggaccgacga agatagtgat ggaattattg ttaataatag
     7261 gactggttgt catggctact cctggtagtg cgcaacttaa tatgtctgct tctgcattga
     7321 gagcttcttc gccgatacag gaaaaggaaa caatagccag tagcaaatag agaatcacgt
     7381 gttttgcttt catttttcta tcaattcttt ctgttaaagt ttggtgtatg ggagatttta
     7441 taacaatatg agattttatt tgttcattat agaatgttgg aaaagaaaga ttttcctatt
     7501 tttgtggaac caaaacttat aagtccatga ctgaatcaga aagaaggcaa attatagagt
     7561 tgattaagaa agaagtcatt ccggctattg gatgtacgga acctatcgca gtagcgcttt
     7621 gtgtagctaa agctgctgaa acgttgggag tgaaaccgga aaagatagac gtcttgctaa
     7681 gtgctaatat actaaagaat gccatgggag tcggaatccc gggaacgggt atggtaggcc
     7741 ttcccatagc tgtggcttta ggtgcgttga ttggcaaatc agactatcag ttggaggtgt
     7801 tgagggactg tacgccggaa gcagtggaac aggggaaacg gttcattgca gaaaaacgga
     7861 tttgtatttc tctgaaagaa gatattacgg aaaagcttta tatcgaagtg atttgtaaag
     7921 cgagagataa aacagctaaa gctatcattg ccggtgggca tactaccttt atatatatag
     7981 ccaaagatga acagacattg ctcgacaagc aacatacagt cagcgaggaa gaggaagatg
     8041 cttcgctcga attaaacttg cgtaaagtct atgactttgc actgactgct ccgttggatg
     8101 agattcgttt cattcttgat acagcccgtt tgaataaagc tgctgccgag caagccttta
     8161 aaggtaatta cggacattct ttaggtaaaa tgcttcgggg aacttacgaa cataaagtga
     8221 tgggtgacag cgtattttct catattctct cttatacatc agctgcttgc gacgcccgga
     8281 tggcgggtgc aatgattcct gtcatgagta attccggcag tggtaatcag gggatatccg
     8341 ctacactccc tgtcgttgtc tttgccgaag agaacggaaa gagcgaagaa gaacttatcc
     8401 gtgctttaat gttaagccat ctcactgtta tatatatcaa acaaagttta ggacgtctgt
     8461 cagctttgtg tggctgcgtg gtagctgcta ccggatccag ttgtggaatc acctggttga
     8521 tggggggaaa ctacaatcag gttgcctttg ccgttcaaaa catgattgct aatctgacag
     8581 gaatgatttg tgacggtgca aaaccgagtt gtgcattgaa agtaactacc ggagtttcga
     8641 cagccgtatt atctgcaatg atggcaatgg aagaccgttg tgtgacttcc gtagagggaa
     8701 ttatcgacga agatgtagat caaagtatcc gcaacctgac aaggatcggc tcgcaagcca
     8761 tgaacgaaac ggataaaatg gtgcttgaca tcatgacgca taaaggatgc tgatttcaag
     8821 tattaagtat caggtattaa gtattagctc aaataacggc ataaaaaaag tattaagtat
     8881 taaagcccgg ctgtgtccgc acggaattaa tacttaatac tttataattt aatactttat
     8941 ttagtgacag tgtccgcctt cgcaaccgca gtcgtcgcca cagccatcac cgcagctgtc
     9001 gcatccgcaa ccacagccat caccaccact catcattttc acaagttcct gaatttcttc
     9061 gttcgtagca ggacggcttt ccagtatttc accttcaaag atcaggtcgg caccagccaa
     9121 cggatggttg aggtcaacta ctacaatatc cggtttgatt tctactacgc tggcatttac
     9181 gcgttgaccg tcaccagtca tcaaaggtac gatgttacct tctttaatac gttcgctgtc
     9241 aaatttgcca tctatttcaa atatattttt ggggaggtca atgacgtgtt gttcgtcata
     9301 ttgtccgtaa gccttatctg ccggaatggt aaggtcaaat ttatcacctt tagaaagagc
     9361 agttatttga ttttcgaagt cttcgagtgt tgttcctaat cctgaaatga attgaaaggg
     9421 atgttctgct tttgcttctt cgaacaactc tttttcacca tcttccattg tatatagttt
     9481 gtatgcaacg gtaatgtact tgttttctac tgtttccatc tgatattttt tgtttctgat
     9541 taataattcc cggtaatccg ggtcgacaaa gatacgaatt atttgcttgt cctctggtat
     9601 agggagggta aatttcagat tattaagtgc ttttgtcaga aaaagaaggt ggagtgtgca
     9661 cttagataat agttgtaaat tcaaccttta agtgataaaa tagagaaata atacctctct
     9721 tttcttacaa ttattcgctt ttaagtgatt tttttcttcg atttgtttgg atataataaa
     9781 aaagccctta cctttgcagc acgaaaataa agaaaagaag atatgaatat gttacataca
     9841 tctattaacc tagcagtcct gcatattatt cgcgtcgtgg tggtcccatc aagagcgtga
     9901 gaaaggtttt tgtgttgtat gtgttcgtac cataaaagat agaatttaga gcctttctca
     9961 cttgtgtgag gaaggctctt taattaaaag atagattgaa atgaaaaagc aattacgcag
    10021 ttcgtttagt acacaaggcc gtcggatggc gggagcccgt gcgttatggg cagccaacgg
    10081 catgaagaag aatcagatgg gtaaacccat tatcgctatc gtcaattcgt tcacccagtt
    10141 tgttccggga catgtgcatc tgcatgaaat cggtcagctg gtgaaggcag agattgagaa
    10201 gctgggatgc ttcgctgcgg aattcaatac aatagctatc gacgacggta tagcaatggg
    10261 acatgatggt atgctttact cgcttccttc acgtgacatc attgcagaca gtgtagaata
    10321 tatggttaat gcgcacaagg cagatgcaat ggtatgtatc agcaattgcg ataagattac
    10381 tcccggaatg ttgatggcgg ctatgcgttt gaatattcct gccgtatttg tatcgggcgg
    10441 tccgatggaa gccagagaat ggaatggtca gcacctggat ttgatcgacg cgatgattaa
    10501 atcggctgat gaaagtgtca gcgatcagga agtagcgaat atcgagcaaa atgcttgtcc
    10561 tacttgcgga tgttgttccg gtatgtttac cgccaattca atgaactgcc tgaatgaagc
    10621 aatcggactg gctcttcccg gaaacggaac catcgtagct acacacgaga atcgtacgca
    10681 gcttttcaaa gatgcagcag aactgatcgt aaaaaatgca aagttatatt atgaagaagg
    10741 agacgaaagt gtgcttcctc gtagcattgc tacccgtcag gctttcttga atgccatgac
    10801 gctggatata gcaatgggtg gttctactaa tacagttctt cacctgttgg ctattgctca
    10861 tgaagcagag gtagatttca agatggatga tatcgatatg ctttcccgca aggctccttg
    10921 tctctgcaag gtggctccca atacacagaa atatcatatt caggatgtaa accgtgccgg
    10981 tggtattatt gctatcatgg atgaactggc aaaaggcggt ctgatagata catctgttcg
    11041 acgggtagac ggaatgtcat tggcggaagc tattaatgaa tattcaatca ccagcccgaa
    11101 tgtaagcgaa aaggcaatta aaaaatattc gagtgcagcc ggaaatagat tcaatctcgt
    11161 acttggttca cagggcatgt actataagga actggataaa gaccgtgcaa acggatgtat
    11221 ccgtgatttg gaacatgctt atagcaaaga cggtggattg gccgtattga aaggcaacat
    11281 tgcccaagac ggttgtgtgg taaaaacagc aggtgtagac gaaagtatct ggaagtttac
    11341 cggacctgcc aaagtatttg attcgcaaga agcagcctgt gaaggcatcc tcggaggccg
    11401 agtcgtcagt ggcgatgtag tcgtcattac gcacgaaggt ccgaagggtg gtcccggtat
    11461 gcaggaaatg ctttatccta cctcttatat caaatctcgt catctcggaa aagaatgtgc
    11521 tttgattacc gacggacgtt tcagtggtgg aacttccgga ttgagtatcg gacatatttc
    11581 tcctgaagcg gcagctggag gcaatatcgg aaaaattgta gacggagaca ttatcgaaat
    11641 cgatattccg gcccggaaga ttaacgtgcg actgacggat gaagaactgg cggcccgtcc
    11701 gatgactcct gtcactcgtg accgttatgt accgaagagc ctgaaggcgt atgccagcat
    11761 ggtaagctct gccgataagg gagcagtgag aattatataa tatagttgat aggtaatagt
    11821 tagctgcgca gcacttagcg caatgattgt aaaccattca ttttcaactg tcatttctca
    11881 actatcattt atcatttatc aactatcaac taatatgaaa gatttaataa caggtgcaga
    11941 ggctttgatg cgctccttgg aacatcaggg agtgactacc atctttggtt accccggtgg
    12001 ttctattatg ccggtattcg atgccttgta cgatcatcaa aatatattga accatatctt
    12061 ggttcgtcac gagcagggag ccgcccatgc cgcacaaggt tatgcccgtg tatcgggtga
    12121 tgtaggtgtt tgcctggtga cgagcggtcc cggagcaacc aatacggtaa caggcattgc
    12181 ggatgcgatg atcgatagta cgcctatcgt ggtgattgcc ggacaggtag gaacaggctt
    12241 tcttgggacc gatgcttttc aggaagttga cttggtaggt attacccagc caatcactaa
    12301 atggagttat cagattcgcc gtgcggaaga tgtagcctgg gcggtagcac gtgcgtttta
    12361 cattgcccgt agtggtcgtc cggggccggt ggtactggac tttgccaaaa atgcgcaagt
    12421 ggagaaaacg aaatacgaac caacgaaagt tgattttatc cgtagttatg ttcctgttcc
    12481 cgatacggac gaggagactg tacaggctgc tgccgaactg attaataacg ctgaacgtcc
    12541 gcttgtattg gttggacaag gtgttgaact gggaaatgca cagagcgaat tgcgcgagtt
    12601 tatcgaaaaa gcggatatgc ctgcgggttg tacgctgctc ggactttcgg ctttgccgac
    12661 agaacatccg ttgaataaag gtatgttggg tatgcacggc aatctgggac cgaatatcaa
    12721 taccaataaa tgtgatgtgc tgattgctgt cggtatgcgt tttgacgacc gtgtgaccgg
    12781 taatttggct acttatgcca aacaggcaaa agtgattcat tttgatatcg atcctgcgga
    12841 agttaataag aatgtaaagg tagatgtagc tgtattggga gattgcaagg aaacactggc
    12901 ttctgtgacg aagctcctga aaaagaacac tcataccgaa tggattgata gcttcaaaga
    12961 atatgagaaa gtagaggagg aaaaagtaat ccgtcctgaa cttcatcctg ccacaaactc
    13021 gttgagtatg ggggaagtgg tacgtgcggt aagtgacgct actcaccatg aagctgtttt
    13081 ggtaacagat gtaggtcaaa atcagatgat atctgcacgc tactttaaat atacgaaaga
    13141 acgcagtatc attacttccg gagggcttgg aacaatgggc ttcgggcttc ccgcagctat
    13201 cggggcaact ttcggagcac cggagcgtac cgtatgcgta tttatgggag atggcggact
    13261 gcaaatgaat attcaggaac tgggtacgat tatggagcag aaggctccgg tgaagattat
    13321 ctgcctgaac aataattacc tcggaaacgt acgtcagtgg caagctatgt ttttcaaccg
    13381 tcgctattcg tttaccccga tgttgaatcc ggattacatg aagattgctt cggcttatga
    13441 tattccttcc aaacgtgctt tcacccgtga agaactgaaa gaagctattg cagaaatgct
    13501 ggcgacagat ggtccgttcc tgctcgaagc gtgcgtagtg gaagaaggca atgttttgcc
    13561 gatgactcct ccgggtggtt cggtcaatca gatgctgttg gaatgctagg ggaagttgaa
    13621 tattgagaat ggaagattga aagttcgcaa ttaaaattta ggattatgag tgacaagaca
    13681 ttatatacga taatagttca ttccgaaaat atagccggat tgctgaatca ggtaactgct
    13741 gtatttactc gtcggcaaat caacatcgag agtctgaatg tatctgcttc ttctattaaa
    13801 ggtgtacaca agtatacgat tacagccttg acggataagg acaccattga gaaggtagtg
    13861 aaacagatcg aaaagaagat cgatgtgatt caggcacatt atttcaccga ggatgaaata
    13921 tacttccatg agattgcact atataaggta tctactcctg cttttcagga aactccggaa
    13981 gcatccaagt tgatccgcag atacaatgcc cgtgtagtgg aagttaatcc ggtattttct
    14041 attgtcgaga aaaatggtat gagcgaagat ataacctcac tctacggtga actgaaggct
    14101 ttaaattgtg ttttgcagtt tgtacggtcg ggacgcgtag cgattaccac cagttgcttt
    14161 gaacgggtga acgagtttct cgatggacgg gaagccatgt ataaccagag taaaaaccaa
    14221 caagaataat gagtgaagaa aataaaatag gaacttatca gtttgtggca gaaccgttcc
    14281 atgttgactt taacggacgt ctgactatgg gcgtactggg aaatcatttg ttgaattgtg
    14341 ccggttttca cgcaagtgac cgtggctttg gtattgcaac actgaacgag gataattaca
    14401 cttgggtact ttcgcgtctg gccattgagt tggatgaaat gccttatcaa tatgaggatt
    14461 tttcagttca aacatgggtg gaaaatgttt accgcttgtt tactgaccgt aacttcgcta
    14521 ttattgataa ggatgggaaa aagattggtt atgcgcgttc cgtatgggcg atgattaatc
    14581 tcaatacccg caaaccggcc gatttactga ccttgcacgg aggaagtatc gtagattatg
    14641 tctgtgacga accttgtcct attgaaaagc cttcacgtat taaagtgaca agcgaccagc
    14701 caatggctac cctgacggca aaatacagtg atattgatat taacggtcat gtgaacagca
    14761 tccgttacat cgagcatatc cttgatttgt tcc
//
