LOCUS       c00173_gnlPro..        13235 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDEKMBAF_173.
ACCESSION   c00173_gnlPro..
VERSION     c00173_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 14:01:16
            Original ID  :: gnl|Prokka|HDEKMBAF_173
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13235
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13235
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6928:13010]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6929..13010
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13235
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13235
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(76..1419)
                     /locus_tag="ctg173_1"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEDLKEATRIENELFRKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVDDLAHAIIKEKRFGFEEIAYLLLSGRL
                     PDKEELSSFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPDADDTSRD
                     NLMRQSIELISKFPTIIAYAYNMLRHATHGRSLHIRHPQENLSIAENFLYMLKKDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSSIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEAYNKTGLIYGIGHAVYTISDPRAILLKEL
                     ARDLAREKGKEREFAFLELLEERAIDVFGRVKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDEVTYVPIKKR"
     CDS             complement(1432..2592)
                     /locus_tag="ctg173_2"
                     /transl_table=11
                     /translation="MEKITVPFISGDGVGAEVTPSMQAVVNAAVRKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAGTPEAEKFYRFLHDDMGVTKV
                     RFPETSSFGVKPVSREGTERLVRAACQYALEHHLPSVTLVHKGNIMKFTEGGFKKWGYE
                     LAECEFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGG
                     IGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSIILSAVMMLEYLGWKEAASLI
                     ENALEQSFTEARATADLARFMPGGVSLSTSAFTREIVRRIENGNNE"
     CDS             complement(2596..4839)
                     /locus_tag="ctg173_3"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKNLYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDIVTATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVVKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASPLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEG
                     YIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLNMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFASGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             4954..6867
                     /locus_tag="ctg173_4"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRTNEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRRLLEFIQNIG
                     NQ"
     CDS             complement(6929..7972)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_5"
                     /sec_met_domain="IlvN (E-value: 3.5e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.1e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(8023..8775)
                     /locus_tag="ctg173_6"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVATL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(8772..9332)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_7"
                     /sec_met_domain="ALS_ss_C (E-value: 5.4e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQEL"
     CDS             complement(9365..11116)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.6e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRQAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(11208..13010)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_9"
                     /sec_met_domain="ILVD_EDD (E-value: 1.7e-219, bitscore:
                     718.9, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQIGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSPDVCKEAIKKYSSAAAGKFNLVLGSQNASYQELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
ORIGIN
        1 agaaaaaatc gttccaccat ggtggaacga ttttttctcc gtgatggaac gatttaaaag
       61 atacaagtct aatccttacc gtttcttaat gggcacataa gtcacctcat ccaaaacatt
      121 cttataggca ggacggataa tacgcttacc ttcaaagttc aattcttcat tgcgatgtgc
      181 acaccaaccg acaatacgtg ccatagcaaa caaaggcgtg aagatttcct gcggcagtcc
      241 aatcatctcg tagacaaagc ccgaatagaa atccacatta ctcgaaaccg tcttgccatt
      301 attcttcaca cggccaaaca catcaatggc gcgctcctcg agcagttcaa ggaaagcgaa
      361 ctcgcgttct ttcccttttt cgcgggcaag gtcgcgggca agctctttca gcagaatggc
      421 gcgcgggtcg gaaatggtat agacggcatg tccgatacca tatatcaagc cggtcttgtt
      481 ataggcttcc ttgttgagca tgcgggtgaa gtaagtatca atctcatcca cattcgtcca
      541 gtcctgaatg ttttcctgca gatggtggaa catatcggca acctggatat tggcacctcc
      601 atgaagcggc cctttcaagg aaccgatacc tgccgctatc gaagagtaag tatccgtccc
      661 ggtagaagaa gtgacacgta cggtaaaagt ggagttgtta ccaccaccgt gctcggcctg
      721 aagaaccagc agcaggtcga gcgtgcgggc atccagctcc gtgtagtcct tcttcagcat
      781 atagaggaaa ttctcggcaa tggaaaggtt ttcctgcgga tggcggatat gcagtgaacg
      841 gccatgggtg gcatggcgaa gcatgttata ggcatacgca atgatggttg ggaatttcga
      901 aataagctca atgctctgcc gcatcagatt atcgcgggaa gtgtcatcgg catccgggtc
      961 aaaacgatac atctcgagca cgctgcgcgc caggatgttc ataatgttgt ttccttcaag
     1021 ttcaatgata ttcatcttgg tcttctgctc cagcggcatg ttatcgttga tgagttcacg
     1081 gaaagaagag agttcttcct tgtcgggcag gcggccggaa agcagcaagt aggcaatttc
     1141 ctcaaaaccg aaacgcttct ctttgatgat ggcgtgtgcc aagtcatcca catcataacc
     1201 gcggtagaac aatttgccgg gaataggctt cagccctcca ccggggatgc gttcatagcc
     1261 aaccacattg cctattttgg tcaaccccac caagactccc gtgccgtcct cattacgcaa
     1321 accgcgcttc acatcaaact tcctgaacag ttcattctca atccgggtag cttccttcaa
     1381 atcttcggaa agcttgtaaa tcagatactc cttcttcata atcgtttcgt tttattcgtt
     1441 attcccattt tctattctcc ttacaatctc ccgggtgaaa gccgaagtgg acagcgagac
     1501 gccacccggc ataaaacggg ccaagtcggc agtagcacgg gcttctgtga aactttgctc
     1561 caaggcgttc tctataagag aggctgcttc cttccaaccc agatattcaa gcatcatcac
     1621 agcggaaagg atgatggaac agggattcac aatgtctttc ccggcaatgt tcggagccgt
     1681 cccgtgagta gcctcaaaaa tggcatgccc cgttttatag ttgatattcg cacccggtgc
     1741 aatgccgatg ccgcctacca tggcagccag ttggtcggac acataatcgc cgttcagatt
     1801 caacgtggca atcacggaat attcttcggg gataagcaac gtgttctgca agaatgcatc
     1861 ggcaatgcag tccttgatga ccagacgccc ttctgccagc tctttaccaa actcacattc
     1921 tgccagctcg tacccccact tcttgaaacc gccttccgta aatttcatga tgtttccttt
     1981 gtgtaccaag gtcacggaag gcagatgatg ctcaagcgcg tattggcagg cggcacgcac
     2041 caagcgctct gttccttctc ttgaaacggg cttcacgcca aacgaggagg tttcgggaaa
     2101 acggactttt gtcaccccca tgtcatcatg gagaaaacga tagaactttt cagcctccgg
     2161 agttccggct tcccattcga tgcctgcata aatatcctcg gtattctcac ggaatacgca
     2221 catatccacc ttctgcggct ctttgagtgg agaaacaata cccttatacc aacgtaccgg
     2281 acgttggcag acatacaaat caagcgtctg acgcaatgcc acgttcaacg aacggatacc
     2341 tccgccgaca ggtgttgtca aaggaccttt gatgcccacc ttataagtgc ggaaggcttc
     2401 catcgtttca tccggcagcc aggagccggt ttcgtggaaa gcacgttctc ctgccagcac
     2461 ttctttccat tcaatgccac gccggtcacc ataggatttc ctgacagcgg cattcacgac
     2521 agcctgcatg gatggggtca cttctgctcc cactccatcg ccggaaataa aaggtacagt
     2581 aattttttcc atattctatc ttgcattaag tgcagaaccg gcccggaacc aggctatctg
     2641 ctgttcgtta tacgtatgtt gtacttcaaa actttcttta ctcccgtcct cgtgatgaag
     2701 aaccaccttc aacgtacgtc ccgaagcaaa atctttcaac cccatgacag aaatcaggtc
     2761 gcgttcccga atcttgtcat aatcggcctt atccgtaaag gtcagtgcca acatgccttg
     2821 tttctttaaa ttcgtctcat ggatacgggc aaagcttttc gccaaaatga cgcgtacatt
     2881 caagaagcgt ggttccatgg cagcatgctc acggctggac ccttcaccat aattctcttc
     2941 ggcaacgaca atggaaggga tgccttctga tttatacagc ttcgcagtgc ctgacactgt
     3001 tccataggta ttggtggagc ggttccaaac cttgttcgtc tctccattga aagcattgac
     3061 agcccccatc agcatattgt ccgaaatatt ctccaaatgt ccccggaaac ggagccatgg
     3121 ccccgccata gagatgtggt cggtggtaca tttcccttgc actttaatca ataaaggcat
     3181 attcagcaag tccatgccat cccaggcagg gaagggagtc agcagttgca agcgctgtga
     3241 atgaggattg accgtaattt ccgtctgtcc tttgcctgga gcaatgtatc cttcctttcc
     3301 tcctataaac ccgtgtgccg gcagttcttc accgaccggt tcggacagtt tcacaacctc
     3361 tcctttggca ttgaccagcg tatccctcaa cgggtcgaaa caaaggtcac cggcaatggt
     3421 cagcgccatc gttatctccg gggaagcgac gtaagcaaaa gtgttgggat ttccatcggc
     3481 acgtttggca aaattacggt taaaagaggt gacgatggaa tttttgcgtt cggggtcatc
     3541 agtatggcgc ttccactggc caatacaagg tccgcaggca ttcgccatta tcgttgcgcc
     3601 aatatcttcg aaagcggcaa tcatgccgtc gcgttcagca gtggcacgta tctgctccga
     3661 accggggttg acaatcagcg gagaagcaac cttcaaattc ttttccttta cctgccgggc
     3721 aagggaggct gcgcggctca aatcctgata ggacgaattg gtgcacgacc ctatcaggcc
     3781 gacttccatc cggcggggat agttattggt tatcactacc tcggcaaatt tcgatatcgg
     3841 tgttgctgca tccggcgtaa agggcccatt gatatacggt tccaacagcg agaggtctat
     3901 ttcaatgatg cggtcgtaat atttttccgg atttgccagc acttcgtcgt cggcgcgaag
     3961 gtcggcagct acggaagcag ccatttttac cacttcttca cgtccggtag ccttcaaata
     4021 agtacccatg cgctcatcgt aagggaaaag ggaggtagtc gcccccacct ctgcccccat
     4081 attgcagatg gtagcctttc cagtggcaga caatgaagcg gttcccggtc caaaatattc
     4141 aatgatggca ttggttcccc cttttacagt aagaataccc gccaacttca gaataacatc
     4201 tttgggagct acccagccac tcaatttacc cttcaagtgt acgcctatca gacgcggcat
     4261 ttttagttcc cattccatgc cggtcatcac atccaccgca tcggcaccac ccacaccaat
     4321 ggccaccatg cccaaacctc cggcattggg cgtatgagag tccgtgccta ccatcattcc
     4381 acccggaaat gcgtagttct ccaataccac ctggtgaata atgcctgctc ccggctgcca
     4441 aaaacctatg ccatagcggg aggaaacatc acggagaaaa ttatagacct cctcgttggt
     4501 cttcgtagca gtcacgatat cttcttttgc acctttatat gcttgaatca aatggtcaca
     4561 gtgcacagtg gaaggcacgg caacctgctc acggcctgca ttcataaatt gcaataaggc
     4621 catttgagcc gttgcatcct gcatggccac acggtcggga cggaaattca catagtcttc
     4681 tccccgtctg tagttcttca ctttatcccc atcatacaaa tgagcataca aatttttctc
     4741 tgctaaagtc atcggacgcc gcagtacgtt ccgtacgcgt tctatcttct ccgaataagc
     4801 ggcataaaac gttttgagca tcgttaaatc atataccata accactattt tttagttttt
     4861 cattattgta aagattacaa attaatatca taaacaaata aaaaggctga atagtttaac
     4921 aaaataaagc attttttccg tcggaagcga agaatgatta cctttgcaac catgaaggaa
     4981 caagattcaa atagtcctat tattcacctc caacagcagc aacttttgct gcgcatggaa
     5041 tacgaatacg aaaaagagga attcaaacgc caaaccgaaa acatgggggt tgcccggaaa
     5101 gtgaaacggg gactttgctg gtatcctgcc actccgggac gaagttacta taattcactg
     5161 aatcaattag taatagaaat tacacacaca gaaaataccg atatagaaca taattttgag
     5221 ttcggccgtc ccgtatgttt tttccgccag tctgccgatg gaaaaataac ctatatgaac
     5281 ttcaccgcta ccgtaagcta tgccgacgag acacggatgg tagcgataat gcccggagcc
     5341 ggtgccgtga tggaagtgca ggaaacggac aacctcggcg tgcaacttta tttcgacgaa
     5401 acatcctatc ggaccatgtt cgaagccttg gaagatacgt tacgctccaa aggcaaccgc
     5461 ctggccgaat tgcgggacat attgctggga acctcgaaag ccggtttccg agagctctat
     5521 cccgtacggt ttccctggct gaactccacg caggaaacag ctgtaaacaa agtgctgtgt
     5581 gctcgcgacg tggccattgt acatggtcct ccaggaaccg gaaaaacgac caccttagtg
     5641 gaagccatct acgaaaccct gcatcgggaa ccgcaggtac tggtatgtgc ccaaagcaat
     5701 actgccgtcg actggatttc ggaaaaactt gtggaccgtg gcgtcaatgt cctgcgtatc
     5761 ggcaatccga cccgtgtcaa cgacaagatg ctttccttta cctacgagcg tcgtttcgag
     5821 aaccatccgc tttatccgga gctgtggagc atccggaaaa atctccgtga actgggcagc
     5881 cgtgcccgcc gtggcagcta tgacgaacgc gaaggagtac gcagccgtat gagccgcctg
     5941 cgcgaccgcg ccaccgcatt ggaaatacaa atcaatgcag agctttttga tggggcacat
     6001 gtcatagcct ccacgctagt aagcagcaat caccggctgc tgaacggacg ccgtttcggc
     6061 acccttttca ttgatgaagc agcccaggcc ttagaagctg cctgctggat agctatccga
     6121 aaagcagacc gcgtggtatt ggcgggtgac cactgccaac ttccgcccac cataaaatgc
     6181 tacgaagctg cccgtggagg tctggaacga acattgatgg agaaagtggt gtccaacaaa
     6241 cctgccgttg tctctttgct gaaagtacaa taccgcatgc acgaggaaat catgaaattt
     6301 ccttcccaat ggttttataa tggcgagttg gaagccgctc ccgaagtgcg ttaccggggc
     6361 atcctggact gggatacccc catccactgg attgacacct ccgaaatgga tttcaaagaa
     6421 gaatttgtgg gagagacttt cggacgcatt aataaggcgg aagcggacct gctcctatca
     6481 gaactgaaaa tctacatcaa ccgtatcggt ggcaaccgca ttctggaaga aaaaatagac
     6541 atcggcatca tctcccctta caaggcacaa gtgcaatatc tccgcagcaa gataaaggca
     6601 gacgcttcac tcaagcctta tcgcagcttg ttcactgtaa atacggtgga tggcttccaa
     6661 gggcaagagc gcgatgttat cttcatcagc cttgtccgta ccaacgaaga aggacagata
     6721 ggattcctga atgatttaag gagaatgaat gtagccatca cccgggcacg tatgaagctg
     6781 gtgatattgg gagaggcaga gacgctgaaa catcacggtt tttaccggag gctattggag
     6841 tttattcaaa atatagggaa tcaataataa agaaataccc cctccggtaa caccgaagag
     6901 ggtatttcac ctatttatat aaagctgatt aattgttttc cggacgaagt ttacgaactg
     6961 taacagctgt ctgccacatt tcgctttcac gcaaggcttt caattctgca ttcagcttct
     7021 cacgataatc gggtttggag ttactgtcga tagaaatctg agcttcgttg cccgacttca
     7081 cacttgcata caatttctgt acaaccggct tgatggcatc atggaacggg gtcatccaat
     7141 ccagcgcacc acgctgtgcc gtagtagaac agttggcata catccagtcc ataccgttct
     7201 tggcaaacaa tggcatcaaa gattgagtca actcttccac tgtttcattg aatgcttcag
     7261 aaggagtatg gccgttttcg cgcaatactt catactgagc caacagcaat ccctggatag
     7321 cacccatcaa tgaaccgcgt tcaccggtca agtcggaagt ggcttcgcgg atgaaagttg
     7381 tctcgaacaa atatcccgaa ccaataccga tacccagtgc aatcgtcttg tcaaaagcct
     7441 tacccgtagc atcctgatag acggcatatg atgagttcaa gccacgccct tcgaggaaca
     7501 tggtacgaag tgaagtaccg gaacctttgg gagcaaccat aataacatca atatctttag
     7561 gaggaaccac gccggtacgg tcgttccagg taatagcaaa accatgagag aagtaaagag
     7621 cctttccggg agtcaaataa ggtttgatag tcggccatac agacattaca gctgcgtcag
     7681 acaacagaca catgacgata gtacctttct gacaagcctc ttcgatgccg aacaaagtct
     7741 cacccggtac ccatccgtca gccaccgcct tttcgtatgt cttgcccgga cgttgtccta
     7801 caatcacatt gaaaccgtta tcacgcaggt tgcaagcctg gcccgggcct tgtacgccat
     7861 aaccaattac tgcaattgtt tcatctttca aaatctcacg tgctttttcc aaaggaaatt
     7921 cttcgcgggt cattacattc tcaataacac cgccaaaatt caattgtgcc attttttgtt
     7981 ttaattttta tttgtggctt acgccaacgt tgataaattt atttatttct ctgtaaatat
     8041 cactttagag cgacagacca cttcgctgcc attctttttc acctccacat cgtaaacgcc
     8101 ctcaccggca tcatccatga acaaagtcaa ctcatcccca taatagcttt cggctacata
     8161 tgccatctca aaacgacgga tgcgcttctc cttatacatc tctatcggga acaaatcaag
     8221 gatatgctcg atgtaacgga tgctgttcac atgcccgtta atgtcaatat cactgtattt
     8281 ggctaccaaa gtagcaaccg gttcctttga ggccaccttt atccgcgaag gtttttctat
     8341 cgggcaaggt tcatcgcaaa cataatctac aatgctgcca ctatgaagag ccagcaaatc
     8401 tgccggctta cgggtattca tgctaatcat cgcccaaacg gaacgtgcgt acccaatctt
     8461 cttgccctct ttatcgatga tagcgaaatt acggtctgta aaaaggcgat agacattctc
     8521 cacccaagtc tgaatggaga aatcttcgta ctgataaggc atttcatcca gttcgacagc
     8581 cagacgggac aatacccaag tataattgtc ctcgtttaga gtcgcgatgc caaaaccgcg
     8641 gtcgctggca tggaaacccg cacaattcaa caaatggttg cccaatactc ccatggtcag
     8701 ccgtccggta aagtcgacat gaaacggttc ggcaacaaac ttgtaggtac ctatcttatt
     8761 gttttcgctc atcataattc ctggtgttta ctttgacgat attttgcttc acggtccgcc
     8821 agatattcat tgacacgctc aaagcagctg gtcgtaatgg ctacgcgacc cgaacggacg
     8881 aactgaagta cgcaatccaa ctggcgcaac tcctcataaa gattggttat ttcctcactc
     8941 atgccattct tctcaacaat ggcaaataca gcattcacct ccacaatacg ggcattgtac
     9001 ttacggatta ctttggacac ctccggtttt tcttccagcg taggggtcgt tattttataa
     9061 agggcaatct cgtgctgata gatttcatca tccgtgaaat aatgggcttg cagcacatct
     9121 attttcttgg taatctgctt ggtcaccttt tcaatggtat ccttatccgt ccaagcggta
     9181 atggtatatt tatgtacccc cttgatggag gaggccgata cattcaaact ctcgatgttt
     9241 atctgccggc gggtaaacac agccgtcacc tgattcagca aaccggcaaa gttttccgaa
     9301 tgaacaatga ttgtatatag ttttttatcc atagatagag taaattcttt aatttcgcat
     9361 gacttcagca ttccaacaac atctgattga ccgaaccgcc cggaggtgtc atcggcatta
     9421 catttccttc ttcctccaca caagcttcga gcaggaatgg tccgtcagtc gctatcatct
     9481 cgtcaatcgc ttttgccagc tcctcgcggg tcattaccct gcgtgcagga atatcatatg
     9541 ccgaagcaat cttcatataa tccggattca tcatcggagt aaacgaataa cgacgattga
     9601 agaacatcgc ctgccattga cgaacattgc ccaggaagtt attgttcaac agaatcatct
     9661 tcaccggagc cttttgttcc atgatggtac ccagttcctg caggttcatc tgcaagccgc
     9721 cgtctcccat gaatacgcat accgtgcggt ccggacgtcc aaaagtggca ccgatagctg
     9781 ccggaaggcc gaagcccata gtacccaggc caccggaagt aacaatgcta cgttccttgc
     9841 tgtatttgaa ataacgggcg gacatcatct gattctggcc gacatcagtc accaatatcg
     9901 cctcgttatg ggtagcctca ctcacagcac gcaccacctc acccatgctt agcgcttttc
     9961 ctgccggatg taattccgga cggattacct tttcctcttc cacttcctcg tattgccgga
    10021 aactgtcaat ccattcctga tggttggcgg gttccagcaa ttgggtaacg gcagccagtg
    10081 tctctttgca atctcccagg acagcaacat cggtctttac attcttatct atttcggcag
    10141 ggtcaatatc aaagtggata atcttcgcct gcttggcata tgtttccaat ttacccgtca
    10201 cacggtcatc aaagcgcatg cctacggcga taaggacatc acatttattg gtattgatat
    10261 tgggccccag gttaccgtgc ataccaagca ttcctttgtt caacggatgg ttcgtaggta
    10321 atgcggaaag tcccaataaa gtgcatccgg caggcattcc ggctttctca atgaaagcac
    10381 gaagctcttg ctgggcttct cccagctcca cgccttgtcc taccagcacc aaaggccgtt
    10441 ccgcaccatt tattaattca gcagcctgcc gtatggcctc cggctccatt tcgggaacgg
    10501 gaagatagct acggacatag tccaccttag taggcgcata ttctgttttc tccacttggg
    10561 cgtttttagc aaaatccagc acgaccggtc ccggacgtcc gctctttgcc acatagaaag
    10621 cacgtgccac tgcccaggcc acatcttctg cacgacgaat ctggtaactc catttcgtga
    10681 taggctgagt aatgcctacc aagtccactt cctgaaatgc atccgtaccc aagaagttcg
    10741 tccctacctg gccggcaatg acaacgatag gcgtactgtc aatcatggca tctgcaatgc
    10801 ccgtgatagt attggtagca cccggtccac tggtaaccag acaaacgcca acctcgcctg
    10861 atacacgtgc aaagccttgt gccgcatggg ttgctccttg ttcatggcga accaagatgt
    10921 ggttcaattc cttccggtgg tcgtataagg catcgaatac cggcatgatg ctccctcccg
    10981 gataaccgaa aatagtcttt actccctgat gctccagaga gcgcatcaat gcttctgcgc
    11041 ctgttattag agcctcaccc cgaccctctc cttgggagag ggaggaaaag ttactctttt
    11101 tattattatc agccatactt tatctattca ttatatttaa aagctcaata gtagcttgaa
    11161 aaatttgttt cattctctcc tcccctcgct ttcggaaagg ggggctttta atcaatcagc
    11221 ctcacagccc ctttgtcagc ggaactcacc atactggcat atgctttcaa tgctttggag
    11281 acttcacggt tgcgggttac cggagtcata gggcgtgctg caagctcttc atccgtcaac
    11341 ttcacattga tagaacggtt cggtatatca atttcgataa tgtccccatc cttaatcttg
    11401 ccgatattac caccggcagc cgcttcggga gaaacatgtc cgatacttag tccggaagta
    11461 ccaccactga aacgcccgtc ggtaatcaat gcacactcct tacccagatg gcgggatttg
    11521 atataagaag taggataaag catctcttgc atacccggtc cacctttcgg cccttcgtga
    11581 gtgatgacga caacgtctcc actgaccacc tttccaccca gaataccgtc gcaagccgca
    11641 tcttgtgagt cgaagacttt cgccggcccc gtaaatttcc agatactctc gtctacaccg
    11701 gcagtcttga caacgcaacc gtcctgagct atatttccct tcaaaaccgc cagaccgcca
    11761 tccttgctgt atgcatgttc caaatcacgg atacaaccgg tcgcacggtc cgtatcgagt
    11821 tcctgataag acgcattttg tgagccaagt accagattga actttccggc tgccgcactg
    11881 gagtatttct tgattgcctc tttacataca tcagggctgg taatactata ccggtcgatt
    11941 gcctctgcca acgtcattcc atccacacgg cggacattcg tatcgaccaa tccgcccttg
    12001 gctagctcat ccatgatggc aatgatgcca ccggcacggt taacgtcttg tacatgatac
    12061 ttttgggtat tgggagccac cttgcataag cagggggtct tgcgggagag catgtcaatg
    12121 tcatccatct taaaatccgc tccggcttcg tgagccacag ccaacaaatg aagtactgta
    12181 ttagtagaac cgcccatcgc aatatccagc gtcatggcat tcaaaaatgc ctcgcgggta
    12241 gcaatactgc gcgggagtac actctcatcc ccttcttcat aatatctaaa ggcattctct
    12301 acaatcaacc tggctgcatc ctcaaatagt ttcttgcgat tttcgtgagt ggctacaatc
    12361 gtgccgttac cgggcagtgc caatccaatc gcttcattca agcaattcat ggaattagcg
    12421 gtaaacatgc ctgagcagca tccgcaagtg gggcaggcat gttgctcaat ctgtgccacc
    12481 tctttatcgc ccacactttc atcagcagat ttaatcatgg catcaatcaa atccaaatgc
    12541 tgtccgttcc attccccggc ttccatcgga ccgcctgaaa caaacacagt cggtatattc
    12601 agcctcatag ccgccatcag catccccgga gtaatcttgt cacagttact gatgcaaacc
    12661 atagcatctg ccttatgggc atttaccata tactccacac tatcggcaat gatatctctt
    12721 gaaggcaggg aataaagcat accgtcgtgt cccatagcga taccgtcgtc aatggcaatc
    12781 gtattgaact ccgcagcaaa acaccccagt ttttcaatct cttcctttac aaactggcct
    12841 atttcgtgca gatgtacatg tccgggaacg aattgtgtaa atgaattgac tatagcgata
    12901 atgggcttac ctatctgttc cttcttcata ccattcgccg tccacaatgc acgggctccc
    12961 gccatgcggc gaccttgtgt gctgaacgag ctgcgtaact gatgcttcat tttcaaatct
    13021 ccttttaatg aaaaagcctc tcccactata gtgagaaagg cttaataaat tatcttctaa
    13081 cgtacgaata catacataac ctttctcacg ctcttgatgc caccaccacg acgcgaataa
    13141 tatgcaggac tgccaggtta atagatgtat gtaaattcat aacttaattc ttcttttttg
    13201 tttcaaacgt gctgcaaagg taagggcttt tttat
//
