LOCUS       c00396_gnlPro..        16288 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BECNEDJF_396.
ACCESSION   c00396_gnlPro..
VERSION     c00396_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 13:39:19
            Original ID  :: gnl|Prokka|BECNEDJF_396
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16288
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..129)
                     /locus_tag="ctg396_1"
                     /transl_table=11
                     /translation="MINGVGDILARHLLQALGEAEAVFTEKQQLLGRIPGIGSNIAA"
     protocluster    1..16288
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3561:6288]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3562..6288
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..16288
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16288
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(162..569)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg396_2"
                     /sec_met_domain="HBT (E-value: 2.5e-09, bitscore: 27.7,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 3.9e-10, bitscore: 30.5,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYIFKLTDKVRDYECDLQGVVNNSNYQHYMEHTRHEFLESLGE
                     NFGKMHEKGVDGFVSRVEIQYKTSLKSGDSYISCLNVYKKGVKLVFEQDIYRASDNALA
                     TKGIVESVIVENGKLTRGEYFDEMLKRIEHT"
     CDS             complement(569..1288)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg396_3"
                     /sec_met_domain="Peptidase_U32 (E-value: 2.3e-40, bitscore:
                     128.3, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVSGKCYLSLHEMNASANRGACMQICRRAYSVKDKDSNIELDIE
                     NQYIMSPKDLKTIHFMNKMMDAGVRVFKIEGRARGPEYVRLVTECYKEAVRAYCNGTFD
                     EKKVAAWDERLRSVFNRGFWDGYYLGQRLGEWSSKYGSGATKKKVYVAKGIKYFDKIGV
                     AEFEMESGNLKVGDEILITGPTTGAVMQTIEEIRVDLKPVDETVKGERFSLKVNEKIRP
                     SDRLYKMEKVQLEKVFE"
     CDS             2260..3240
                     /locus_tag="ctg396_4"
                     /transl_table=11
                     /translation="MEDVTDISFRLMCKRFGADMVYTEFVSADALIRSVNKTQQKLNVA
                     DEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVKRVAGKGAGAGMLRNIPL
                     MLDITREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCGIAALSIHGRTRAQMYTG
                     EADWTLIGEVKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVDAVMIGRGSIGRPWIFRE
                     VRHYLDTGETLPAESFSWYLNILKKQVEQSVERLDERRGILHIRRHLAATPLFKGITDF
                     KQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSESIDC"
     CDS             complement(3213..3371)
                     /locus_tag="ctg396_5"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSIDSDT"
     CDS             complement(3562..4317)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg396_6"
                     /sec_met_domain="Fer2_3 (E-value: 1.3e-26, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 3.8e-12, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4e-06, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             complement(4345..6288)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg396_7"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.1e-60, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.8e-38,
                     bitscore: 121.6, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFISGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             6486..6917
                     /locus_tag="ctg396_8"
                     /transl_table=11
                     /translation="VKPQSNEPDQIQHRIHNIALEVEIDKRCTILRMNVTMNTCQFGKH
                     HVVPELSKVQNHEQDNDHTQNKHVLRSPFNTFRTSVDGITVVTASLTILQSQDNSIHEV
                     HDYTCSQHQCTEQSIPVRTQQTANHVIRFTRKYCRNVHT"
     CDS             6904..7008
                     /locus_tag="ctg396_9"
                     /transl_table=11
                     /translation="MFIHKWNTKNRMRKRPDILIISFFPIEELSNHIR"
     CDS             7261..8214
                     /locus_tag="ctg396_10"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSETSCSVVDTGKTLDYKIGDKLL
                     FSYNYTTVYPAPGVDSVYKRSGFIHPLKTLGGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFERD"
     CDS             9271..12552
                     /locus_tag="ctg396_11"
                     /transl_table=11
                     /translation="MLKKTKLVSLMLLAGTLAVPESAFAEITPERPSVSLSQQNGKVVC
                     VVEDSFGPVIGASVVVKGTTNGNVTDMDGKVVLENLKKGDVIQISYIGYATQEITYTGQ
                     PSIPVTLKEDTQALQEVVVVGYGTQKKENLTGAVAAVAGDVLENRPITNVGQGLQGVVP
                     NLNVTMSKGGAPGSSSDFNIRGNNSINGGSPLVLVDNVQMDANLVNPEDIASISVLKDA
                     ASAAIYGARAAYGVILITTKKGKSEQKPQISVSASGYWQSPALRMHNINSLEYLEMRDI
                     AAANSGMSSLITPGQLDYVKKYMDGSYKYSEYFDQSQDQSRWIYCGNTDWFNELYKTSF
                     SQQYNVNISGGDSKTTYYGSVGFADQNGILKTADDNYKKFNATLNLSSQLTKWLQVSAK
                     IADNYSTEDHPITNSTAGIDAYGGMLKNDLSPLMPVRFGHTGRLVYSPGAAAINDSNLG
                     IQTSGDYIYKEEGINNYSGQNGNTNPAAVGDLGGYTKYKINDLWLTGAVKITPLEGLVI
                     NADYTYNIYSKNASEVQRTFTDYTAVAGTEALYGWTKPSYANYTTNEDYYYAFNAFAEY
                     SKSFLENTHNFKIMAGYNQEKKSNKKYNAKRTNLIVEDIPDLDLATGEQSMSSEDTYWA
                     INGFFFRFNYNYKQRYLLEVNGRYDGSSKFAKDHRYAFFPSVSAAWRISEENFWQPLKG
                     WWNDMKIRGSYGSLGNQVMDDLGNFPYLATYGTNSSYNYLINGSKPVIVKAPGLVAPDF
                     TWETVTQMDFGFDASFLNNRLTGTFDWYRRNTKDMLVAGATLPATLGASVPKSNSADMK
                     TIGWELSLGWNDRLENGFSYWVKGVLSDYQATITKYAGNDAGFYSQSDGDGKYYVGQKI
                     GEIWGYHSNGLFQSDDEAATIDQSELYAGKWGAGDVKYEDLDNDGKITKGEETIYNPGD
                     KSIIGNKTPRYQFGITVGFDYKNFDFEMFWQGTGKRDYMLSGAQFWGFTSQWDVPYTPA
                     LDYWTETNTDAYFPRPGWQNGGNRVTSDRYLQSAAYGRLKNLTVGYTIPKNLTTKWGIS
                     RLRLYVTGENLLTITPLNDAFDPETLGGMTYPINRKVAIGLNLTL"
     CDS             12725..14422
                     /locus_tag="ctg396_12"
                     /transl_table=11
                     /translation="MNLTGKGLRADGSENLDDLNTLDERSDNRLVASPDQWLFNEWVIP
                     SEANFDSKWYWNNIRNLNYFMTRYQRVNATESEVNPVVAVIRFFRAFDYFDKIKTFGDV
                     PWYEKDLTTADIDELYKARDDRDFVLGKIIEDLEFAIEWLPEKSAAEVGALHKDAARTF
                     LARVCLHYGTYKKYHNVSTSPTSQELLQKAATLAKEVMDSGLYDIVQGSDAGANQSAFA
                     DYPLYYANQFTQEDLTTNKECILARVFEADVLTHNLARGGGVGLSKDFAESFLCKDGLP
                     IANSSEYKGDETLDDEMANRDPRMYQIIDSKYRPYTVKSNGMRVVNSGIDDKKEFSPSE
                     EPGTNIHSAPGLTGTATGYSPIKLVSASQSQQDAVKTSSYDWFVFRYAEILLIYAEAKC
                     ELGECTQAVLDETINKLRDRVEMKHLTVSPVADLNPVDYGYSITPLLYEIRRERRIELA
                     LEGFRYDDIMRWNAMKLFENPKTYLGMRVTDKVKALYQPEVFEGSTARDLIEYNGKTYI
                     RMYSGKSLNEAGRKWTGNDKRLYYPIPTSQITLSASHGSLLKQNPGWE"
ORIGIN
        1 ggcagcaata ttgctgccga taccagggat ccttcctaac aactgttgct tttcagtaaa
       61 cacagcctct gcttctccca aagcctgcag gagatgacgc gccaggatat ctcccacgcc
      121 gtttatcata gtaaggccga tttggtaaat ccgtttgtca gtcatgtatg ttctattctt
      181 tttagcattt cgtcgaaata ttcaccgcgt gtcaactttc cgttctcaac gataaccgac
      241 tcgacgattc ctttcgtcgc caatgcattg tcagaagccc tatatatatc ctgctcgaat
      301 acgagcttga ctcctttttt atagacattg aggcaagaga tatagctgtc gccgctcttg
      361 agcgaggtct tatactggat ttctacccgc gatacaaatc cgtcaacccc tttttcgtgc
      421 atctttccga agttctcgcc aagcgactcc aagaattcat gccgagtatg ttccatataa
      481 tgctgataat tggagttgtt gaccactcct tgcaggtcgc attcgtagtc acggaccttg
      541 tctgtcagtt taaaaatata ctctttcatt attcaaatac cttttcaagt tgaacctttt
      601 ccattttata caatcggtca gacggccgaa tcttctcgtt caccttgaga gagaaccgtt
      661 cacctttaac ggtctcgtcc accggcttca agtccacacg gatttcttct atcgtctgca
      721 taaccgcacc cgttgtcggt ccggtaatca ggatctcatc acccactttc aggttaccgg
      781 attccatttc gaactccgcc acgccgatct tgtcgaaata tttgattcct ttggcaacat
      841 acactttctt cttagtcgcg ccggagccat atttgctact ccactcaccc aaccgttgcc
      901 ccaaataata gccgtcccag aatcctcggt tgaacacact gcgcaggcgt tcgtcccaag
      961 cggcaacttt cttttcatcg aacgtgccat tgcaataagc acgcacagct tccttatagc
     1021 attcggtcac caggcggaca tattcgggac cgcgggcacg tccttcgatc ttgaataccc
     1081 gtacacctgc atccatcatc ttattcatga aatgaattgt cttaaggtct ttaggcgaca
     1141 taatatactg gttttcgata tccagttcga tattgctgtc tttatctttt accgaataag
     1201 cacgccgaca aatctgcatg caagctcccc ggttggcgga agcgttcatt tcgtgcaggc
     1261 tcaggtaaca tttaccggaa acggccatac agagagctcc gtgggcaaac atttcgatac
     1321 ggaccagttc tcctttcggt cccgtaatct gctggtcgac gatctgccga tagatttcat
     1381 gcacctgttt caaattcagc tcacgcgcca agacgacaac atcggcaaaa cgggcataga
     1441 atttcagtgc ttccgcattg gaaatgttga gctgtgtgga aagatgcacc tcctgtccga
     1501 tgctgttggc atagttcata gctgccacat cggccgcaat gatcgctgaa acttccgcct
     1561 ccttcgccgc atcgataatc tcgcgcatca gaggcaggtc ttccccataa ataaccgtat
     1621 tgacggtcaa atagctctta ataccgtgct cacgacaaag cgcaacgatc ttgcgcaaat
     1681 cgtctgtcgt aaagttattg gaagagcgcg aacgcatatt caatccttcg ataccgaaat
     1741 agatagaatc ggctccccct tggatagccg ccatcagtga ttcgtacgaa ccgacaggcg
     1801 ccattatttc aaaatctttc tcgttcaagt tcttatacat ttactggttc gttcgcaaag
     1861 gtaggaataa tatccgagaa gaattgcatg ggtatccgtt tctcagagca tcaaaatcgt
     1921 gatcaaatac cattttctat aaagatttgc aaaacaacca tcatactgtc attgttgtcc
     1981 tttagaatct gttattcaat accttaagac atgatagttt ctatttttaa ctatcatact
     2041 actatcatgc aactatcatg atttcagctt atcattttat ctatatcatt gacagtatga
     2101 catttgtact ttctattgat caattactac actttttagt agatatcctt ttatccctgt
     2161 ttttagcagg aaatcagtac ctttgtcccc gtcattgata atataaatat gaaaataggt
     2221 acaatagatt taggcgaacg ccccgtcttc ttagctccga tggaagacgt tacagatatt
     2281 tctttccggt tgatgtgcaa acgttttggt gccgatatgg tttataccga attcgtttca
     2341 gcagacgccc tgatccgcag tgtaaataaa acacagcaaa agctgaatgt ggcggatgaa
     2401 gaacgtccgg tcgccataca aatatatggc cgtgatgttc cgacaatggt cgaagccgcg
     2461 caaatttgcg aagccgctca tccggacatt ctcgatatca atttcggttg ccctgtcaaa
     2521 cgagtggcag gcaaaggagc aggcgccggc atgctgcgca atattccact gatgctggac
     2581 atcacccgtg aagtcgtcaa agcggtgaac atccctgtca ccgtaaaaac ccgcttgggc
     2641 tgggatgccg acaaccggat catcgtagac ttggccgaac agctacagga ttgcggtatc
     2701 gcagcccttt ccatccacgg acgtacccgg gcacagatgt atacaggaga ggcagactgg
     2761 acactgatcg gtgaagtaaa aaacaatccc cgcatacaaa ttcccatcat cggcaatggc
     2821 gatgtgactt ccgccgaaat ctgcaaacaa cgtttcgaac aatatggcgt ggatgccgtt
     2881 atgattggcc ggggcagcat aggccgcccc tggattttca gagaagtgag gcattatctg
     2941 gatacaggcg agacattgcc tgccgaatct ttttcatggt atctgaacat actgaaaaag
     3001 caggtggaac aaagcgtgga acgtttggat gagcgccggg gaattctcca cattcgccgc
     3061 catttggctg caactccgct gtttaaaggt attacagact tcaagcagac acgcgtcgcc
     3121 atgctacgtg cggaaacagt ggaagcatta ttcgacattc tggattccat ccccgacaaa
     3181 tttcatacag gatacggatt tcaaagcgac tctcaagtgt cagaatcgat cgattgttga
     3241 tataataaca gtgtgaatcc gcacacagtg tcaattttaa aacaaaaagt agcaaatttg
     3301 caataaaatg taattacaaa ctcttgcgta ttcagtaaat atactttata tttgcagtga
     3361 gtttttttca tagtatttta gatctaaggt taacaaagtc tttgcagaga gggaatcgag
     3421 agactgtttc actggaaagc aacaaaaaag ccgcatccac ttttattata gggagtgcgg
     3481 cttttttgtg ggtttgaacg aacataaaga aagcccgttg ccattgacga cgggcttttc
     3541 catatacata tatataatgt attagtcttg taacttagca gagatgaact cgcggttcaa
     3601 gcgagcgatg ttgctaacgg agatgttctt cggacattcc atttcgcaag cgcgagtgtt
     3661 cgtacagtta ccaaagccca gttcatccat cttagcaacc attgcttttg cacgacgagc
     3721 agcttccacc ttaccctgag gcaaaagagc cagctggcta acctttgcag agacgaacag
     3781 catagctgaa ccgttcttac aagcagcagc acaagcaccg cagccgatac aagcagcagc
     3841 atccatagcc aaatccgcat cagccttaga aataggaatt gcattagcat caggaacccc
     3901 acctgtgttt acagaaacga aaccacctgc ctggataatc ttatcataag cataacggtc
     3961 taccatcaag tcgcggatta ccgggaaacc ggcagaacgc cacggctcga tcgtaatcgt
     4021 ctcaccatca ttgaaacggc gcatatagag ctgacaggtt gttgcacctg ttgccggtcc
     4081 gtgcggatgt ccgtttacat acaatgaaca cataccgcag ataccttcac ggcagtcgtg
     4141 gtcgaatacg ataggttctt taccttcgct aaccaaacgt tcattcaaaa tgtctaacat
     4201 ttccaagaaa gaaacactct gattgatttt gtcgatttgg taagtctcaa actgtccttt
     4261 atctttcgga cctttctgac gccaaacttt aagtgttacc tttatatctt tatccatgat
     4321 tctaattttt gtgattgatg attattactt cttgtagtta cgtgtttgag gaacaacgaa
     4381 ctgatagttc aaatcttcct tcagcataac cgggtctttg tcttcaccct ggtattccca
     4441 acaagagacg tacatgaact tatcgtcatg acgcatagct tcgccttctt cggtctgatg
     4501 ttccgtacgg aagtggccac cacaagattc tgcgcggtct aacgcatcgt gtgccatcaa
     4561 tgcaccgatt tcgataaagt cagccaaacg caatgccttg tccaattcca cgttcaagct
     4621 gttggcctca cccgaaatga atacattgct ccagaattcc ttcttcaggt ctttcaacat
     4681 ttggatagct tctttcaagc cttccgcgtc gcgtgccata ccgacgtgtt cccacatgat
     4741 atgtcccagc ttacggtgga tagaatcgac agtttcttta cccttcacgt tcatcaactt
     4801 cgcgatacgg gcgttaatag ccttttctgc ttccacaaat tcaggcaggt cagtgctaaa
     4861 gcgcggaacc tggatctggt cagacagata gttctggatc gtgtaaggca atacaaagta
     4921 accatcagcc aatccctgca tcaaagcaga agcacccaga cggttagcgc catggtcaga
     4981 gaagttggct tcaccaattg cgaacagccc cggaatagaa gtcatcaatt catagtctac
     5041 ccacaaacca cccattgagt agtgcaatgc aggataaatc atcatcggag tttcgtacgg
     5101 atcatcgttc gtgatctctt cgtacatatc gaacaggtta ccatatttct gtttaaccac
     5161 ttccttaccc agacggttga tagcgtcgga gaaatccagg aatacagcca agcccgtgct
     5221 atttacaccg aaaccggcat cacaacgttc tttagcggca cgtgaagcca catcacgagg
     5281 aaccaagtta ccgaatgccg gataacgacg ttccagatag tagtcgcgat ctgcttcagg
     5341 aatatccttt cccttttttg ttccggcctg caatgccttc gcatcttcca gcttcttcgg
     5401 aacccagatg cgaccatcgt tacgcagtga ttcagacatc aaagtcagtt tagactggaa
     5461 gtcacctttc accggcacac aagtcgggtg gatctgcacc atacaaggat tagcaaagta
     5521 agcccctttc ttgtagcact gccatgcagc agaaccgtta gacgccatcg cgttagtaga
     5581 caagaagaat gtatttacat aaccacctgt cgcaacaacg actgcgtgag cggcaaaacg
     5641 ttcgatctta ccggtaatca aattacgggc aataataccg cgagcacgtc cgtcaacctt
     5701 cacaacatcc agcatttcat ggcgtgtgta catcttcacc tttcccaaac caatctgacg
     5761 gctcaatgca gagtaagcac ccaatagcaa ctgttgtccg gtctgaccac gggcatagaa
     5821 cgtacgggat acctgagcac caccgaatga gcggttatcc aacagaccac catattcgcg
     5881 agcgaatggt acaccctgtg ccacacactg gtcgataata gagtttgaca cttcagccag
     5941 acgatagacg tttgcttcgc gggcacggta gtcaccacct ttgattgtat cgtagaacag
     6001 acgataaacc gagtcaccat cattctgata attctttgcc gcattgatac cgccctgtgc
     6061 agcgatagag tgtgcacgac ggggagagtc ctgaatacag aaattcaata cattgaatcc
     6121 catttcagcc aaagaggcag cagcagaagc acccgccaga ccagtaccta ctacaattat
     6181 gtccaaacga cgtttgtttg cgggattcac caatttctgg tgatttttat aatttgtcca
     6241 cttctcagcc aacgggcctt gaggaatttt agaatctatt tgagtcataa tgttttattt
     6301 tcaaattgaa aaaataatat ccgaaattaa gcacctacac cgttcaggta gaagataact
     6361 gtgataacag cgaataagcc acaaataata gtggcaaccc atttagagat acattcccaa
     6421 cggcttaacc aaacggtatt gttccagcca attgtgtgaa tcgcagacca gaaaccgtga
     6481 gtcaggtgaa accacagagc aacgaaccag atcagataca acaccgtatt cacaacattg
     6541 ccctggaagt agaaattgat aaacgctgca ccatcctgcg gatgaatgtc accatgaata
     6601 cctgccagtt cggcaaacat catgttgtac cagaactgag taaagtgcag aaccatgaac
     6661 aggataacga tcacacccaa aacaaacatg ttctgagaag cccattcaac acctttcgga
     6721 cgagcgttga tggcataacg gtcgttaccg cgagccttac gattctgcag agtcaagata
     6781 atagcataca cgaagtgcac gactacacct gcagccaaca ccaatgtacc gagcaaagca
     6841 taccagttag aacccagcaa accgcaaatc acgttatacg cttcaccaga aaatactgcc
     6901 gcaatgttca tacataagtg gaacaccaag aacagaatga gaaaaagacc tgatatactc
     6961 attatcagct tcttcccgat agaagaatta agtaaccaca taagataata atttaagtta
     7021 tttaattgta tttagaaatt tcctccaatc tatggttatt atcgtgcaaa ggtatgctaa
     7081 atccccatat cacgcaaacg attaaagaaa tatttcatca attagaacac tgcttgctgg
     7141 ctggttttat ttgcatcaga tatcacaaac ggattgtgcg aaatgaaaaa atttcgtttt
     7201 tttgtagccg atacaggcaa ggtcttgccg gataactgat tattatttaa ttgtcatatt
     7261 atgaaaactg ctattttttc tattggtgtt tttttgattt ctctgttctt aggctcttgt
     7321 cagccttccg aaacatcctg ttccgtcgtc gacacgggga aaaccttaga ctataagata
     7381 ggagataaac tgttgttctc ttacaactat accacggttt acccagcccc tggcgttgac
     7441 tcggtctata aacgcagcgg tttcatccat cctttgaaga cattgggagg cgaagtgatg
     7501 accaattgtt ctcccgccga ccattaccat catttcggtt tgtggtatgc ctggacgaaa
     7561 actacgttcg aaggaaacga gatcgatttc tggaatctcc acaaaaaaca aggaacagtt
     7621 cgcttccgca acttcgaaca cgtatccgac aacggttttg ttgcgacact ggaccatgtg
     7681 gtctaccccg attctcccgc agaaaaagta gcaatgaacg aacgcctgga gatcaacatc
     7741 gggacaacat ccttaccagg ttattacatc gactatcata ccactatccg cctcgccagc
     7801 cctagcccga tcaccatgga agcttaccgt tatggcggca tatgcatccg tacgcgcgaa
     7861 gactggaacg atcagacagc cgaaatgctc acctcggaag gcctttcccg cgacgaagct
     7921 gacggttcga gagcccgttg gtgctactac caagggaaag ccggaaacga aaaggcctgt
     7981 atcctaatcg ttgcctcccc ttccaacctg aactatcctg agcctttacg cgtatgggac
     8041 aaaacagtca acaagcctgc cggtgacgtc atgtggaatt tctcaccgac caagcagaag
     8101 gcattcacct tggaacccgg taaagaactg agcctgtctt accgcattta tgtattggac
     8161 aagaacatca acgctactac ggcagaagtg ctgtccgatt tcgaacgtga ttgaatttct
     8221 actaaaacaa actgacaatt tgcagggcaa ggtaaacaag aaaaggaaaa agggcttgtt
     8281 ctcctatatc atcaaagaca aggctctttt atgtaaatac agctacaaat caatgaaaaa
     8341 cacgtaataa aacttaccca acacccccat gtatccgccc ccgacacccg gatcttacgc
     8401 tcttatagat ccgggtgtcg ggggcggata catgggggtg ttggtgaaat tgtctcccta
     8461 cttttacctt aaaatgcttg gagtttattc atttaaaaca gatagatgag cgattacaga
     8521 tagtgataga agcgtgatat ataaaacagg tatctatcac tttagatacg cactgattat
     8581 caagactcac acgacattta gtgatagagt gacagatgtt catgaaaaaa catccaagaa
     8641 atcaccccat cccgactact gagcttcaac aaagttgcac taaaattaga taaattaaca
     8701 caggcattgt atttcattgc ctattgccct tttcccagtt tttcgacaga tacaaaatca
     8761 tgttctgtgc tgatgagaat atgcataacc acaaaacttt cagacaaata tgcaatatta
     8821 taaaaataag attatttttt gaccacccat gcacagaaag agatataagt tctatcagaa
     8881 ctcatgtatt tatgaagaaa tgtatctgat aagtgtgaat attgtacaaa aatagagttg
     8941 aatgataagc cgcaaattac ttcttgtgct taaaaaggtt caaaagtctg atattgtctg
     9001 atgcttgttg atagcctgta agtctgaatt gttaaaaatg agtgccgtat gaactttttt
     9061 aataaaaaaa catacaacga aatgaaaatt tcataccttt gacccggata tgagataatt
     9121 aaaaaccata gttctgatag aactaaatta caaaaacaca gaaaaacgct ataaaaatat
     9181 gcaaaatcta atgagcatga tctaataaag acactcaaca gatgtaagcc gttttcgtgg
     9241 tatgtattat ttcttttaaa tatatactct atgttgaaaa aaactaaatt agtaagtctg
     9301 atgctactgg caggaacttt agctgttcca gaaagtgctt ttgccgaaat tactccggaa
     9361 aggccgtcag taagtctatc ccaacaaaat gggaaagtag tatgtgtggt ggaagattcg
     9421 ttcggccctg tgatcggagc ttcagttgtt gtaaaaggaa caaccaacgg aaatgtgaca
     9481 gacatggacg gcaaagttgt tttggaaaat ttgaagaaag gagatgttat tcaaatttct
     9541 tacattggat acgcgacaca ggaaataacc tatacaggac aaccgtcaat ccctgtaaca
     9601 ttaaaagaag atacccaggc gctacaagaa gtagtagtag taggttacgg tacacagaaa
     9661 aaagagaatt tgacaggtgc tgtggcagct gttgccggtg atgtactaga aaaccgtcct
     9721 ataacaaatg ttggacaagg attacaaggt gttgttccaa acttaaacgt caccatgagt
     9781 aaaggtggtg ctcctggtag tagctctgac tttaatattc gtggtaacaa ctcgattaac
     9841 ggtggtagcc ctttagtgtt agttgataat gttcaaatgg atgccaacct tgttaatccg
     9901 gaggacatcg cgtctatttc tgttttaaag gatgccgcat ctgctgctat ctacggtgcc
     9961 cgcgctgctt atggcgttat tttaattaca acaaagaaag gtaaaagtga acaaaaacct
    10021 cagatttccg tatcagcaag tggttattgg cagagccctg cattaaggat gcacaatatc
    10081 aactctttgg agtatctgga aatgagagat attgctgccg ccaatagcgg gatgagttcc
    10141 ttgatcactc cgggacaatt agactatgta aagaaatata tggatggctc ttataagtat
    10201 tcagaatatt tcgatcagtc gcaagatcaa agtcgatgga tttattgtgg caacactgat
    10261 tggtttaatg aattgtacaa aacaagtttc tctcaacaat ataatgtaaa cattagtggt
    10321 ggagactcaa aaacaactta ttacggctct gtcggatttg ctgaccagaa tggtatttta
    10381 aaaacagctg atgataatta caagaaattt aatgcgacac tgaatctttc ttcacaactg
    10441 acaaagtggt tgcaggtcag tgccaaaatc gcagataatt attcaacaga ggatcacccc
    10501 attaccaact ctacagcagg aatcgatgcc tatggaggta tgttgaaaaa tgacttaagc
    10561 ccgttaatgc ctgtacgttt tggccataca ggaagactcg tttatagtcc tggcgcagca
    10621 gccatcaatg attctaactt aggtatccaa acttcaggcg attatatcta taaagaagaa
    10681 ggtattaaca actattcagg tcagaacggg aacacaaatc ccgctgctgt aggagattta
    10741 ggcggatata ccaaatataa aatcaacgat ttatggttaa caggtgctgt aaaaatcaca
    10801 cctttggaag gattggttat caatgctgat tatacatata atatttatag caagaatgca
    10861 tcagaggttc aacggacatt tacagattat acggctgtag ctggaacaga agctctttat
    10921 ggttggacaa agccaagtta tgcaaattat actacaaatg aagattacta ctatgcattc
    10981 aatgcatttg cagaatattc taaatcattt ttagaaaata cgcataactt taagattatg
    11041 gccggttata accaagaaaa gaaatccaac aaaaaatata atgcaaaacg taccaatctg
    11101 attgttgaag atattcctga cttggatttg gcgacaggtg aacaaagcat gtcttcagaa
    11161 gatacatatt gggcaattaa tggtttcttc ttccgcttca attacaatta caaacaacgt
    11221 tatctactcg aagttaacgg ccgttatgac ggttcatcca agtttgcaaa agatcatcgt
    11281 tatgcattct tcccatctgt ttccgcagca tggcgtatct cagaagaaaa tttctggcag
    11341 ccgttaaaag gttggtggaa tgatatgaaa atccgtggtt cttatggttc attgggaaat
    11401 caggtaatgg atgatctagg taatttccca tatttagcaa catatgggac gaattcttcc
    11461 tacaattatt tgattaacgg atccaaacct gttattgtaa aagcaccggg gcttgtcgct
    11521 cctgatttta cttgggaaac agtcactcaa atggacttcg gttttgatgc ttcatttctg
    11581 aataatcgac tgacgggaac atttgactgg tatcgtagaa atacaaaaga catgttggta
    11641 gccggagcaa ctttacctgc aacattgggc gccagtgttc ctaaaagtaa ctctgctgac
    11701 atgaagacca taggctggga actttcttta ggatggaatg atcgattaga aaatggattt
    11761 tcttattggg taaaaggtgt tttatctgac tatcaggcaa ctattaccaa atatgccgga
    11821 aatgacgcag gtttctattc acaaagtgat ggtgatggta aatattatgt aggacaaaag
    11881 attggtgaga tttggggata tcactcaaac ggccttttcc aatcagacga tgaagctgca
    11941 acaatagacc aaagcgaact ttatgctgga aaatggggtg cgggtgatgt aaaatacgaa
    12001 gacttagata atgatggtaa aatcacaaaa ggggaagaaa caatctataa cccgggtgat
    12061 aagagcatca taggtaataa aacacctcgt tatcaatttg gtattaccgt tggatttgat
    12121 tataagaact tcgatttcga gatgttttgg caaggaacag gaaaacgtga ctatatgttg
    12181 agtggcgctc agttctgggg attcaccagc caatgggatg ttccatatac tccggccctt
    12241 gattattgga cagaaacaaa tacagatgct tattttccaa gaccaggatg gcaaaatggc
    12301 ggtaacagag tcacaagtga ccgttattta caaagtgcag cttacgggcg tttgaagaat
    12361 ttgacggtag gttacacaat tccgaagaat ctaacgacaa agtggggcat ttctcgtttg
    12421 agattatatg tgacaggaga aaacctactc actatcactc ctctgaacga tgccttcgat
    12481 cccgaaacat tgggaggaat gacatacccg attaatcgaa aagttgcaat tggattaaat
    12541 ttaacactgt aaaaaacgaa agatgacaat gaaaactaaa catatcttat taggattaag
    12601 tcttggattg ttaggaggat ttacggcttg tgacgtgaca gacctcaatc caaaagacag
    12661 cattaccgac aatagctact ggaatacagt tagcgatttg gaaaattatg ccaaaggctt
    12721 ttacatgaac ctgacaggaa aaggtttaag ggcagatgga agtgaaaatt tggatgattt
    12781 aaatactctt gatgaaagaa gtgacaatcg tctggtcgct tctcccgacc aatggttgtt
    12841 caacgaatgg gttatacctt ctgaagcaaa tttcgattca aaatggtatt ggaacaatat
    12901 tcgtaatcta aactatttta tgactcgtta ccaacgggta aatgcgacag aatctgaagt
    12961 aaatccggtt gttgccgtaa ttcgcttttt ccgggctttc gattatttcg ataaaatcaa
    13021 gacatttgga gatgttcctt ggtatgaaaa ggatttgaca actgccgata ttgacgaatt
    13081 gtataaagca cgtgacgacc gtgactttgt actagggaaa attatcgaag atctggaatt
    13141 tgcaattgaa tggttaccgg aaaaaagtgc agcagaggta ggtgctttac ataaagatgc
    13201 cgctcgtaca tttttagccc gtgtttgcct acattatgga acatataaaa agtatcataa
    13261 tgtttcgaca tcacctacat ctcaggaatt attacaaaaa gcggcgactc ttgccaagga
    13321 ggtgatggat agtggtcttt acgatatcgt acaaggctcg gatgccggag caaaccagtc
    13381 tgcttttgcc gattatccct tgtattatgc aaaccagttt acacaagagg atttaacgac
    13441 taataaagaa tgtattttag cacgtgtttt cgaagcagac gtattgactc ataatctcgc
    13501 tcgtggtgga ggagtcggcc tttctaaaga ttttgcagaa tcattccttt gcaaggacgg
    13561 tttgcctatt gcaaacagta gtgaatacaa gggagatgaa acactggatg atgaaatggc
    13621 aaaccgcgat cctcgtatgt atcagattat agacagtaaa tatcgtccat atacggtcaa
    13681 aagcaatggt atgcgtgtag taaattccgg tattgatgat aaaaaggaat ttagtccgtc
    13741 tgaagaacca ggaacaaata tccattcagc tccgggatta accgggactg ccacaggata
    13801 ctcacctatc aaactggtgt cagcaagcca gagccaacaa gatgcagtga aaacatcttc
    13861 ttacgactgg tttgttttcc gttacgcaga aatcctgctg atctacgctg aagccaaatg
    13921 cgaattaggt gaatgcacac aggctgtttt ggatgagacg attaataaat tgcgcgaccg
    13981 tgttgagatg aaacatttaa cagtatctcc agtagccgat ctgaatccgg ttgattatgg
    14041 gtattctata actccgttgt tatatgaaat ccgccgtgaa cgtcgtatcg agttggcttt
    14101 ggaaggtttc cgttatgatg atatcatgcg ttggaatgcg atgaaactat tcgaaaatcc
    14161 taaaacatat ctaggcatgc gtgttacaga taaagtaaaa gcgttatacc aacctgaagt
    14221 atttgaagga tcaacagccc gtgatttaat cgaatataat ggtaaaactt atatccgcat
    14281 gtattctggt aaaagtttga acgaagccgg ccgtaaatgg acaggaaacg acaagcgtct
    14341 gtactatcct atcccaacaa gtcagattac attgtctgca agccatggtt ctcttctaaa
    14401 acaaaatccg ggttgggaat aaatctcata caagagggaa ggttagcctt ccctctttat
    14461 ttccctcaat aaaatataat gagaatatat tacttatctt attgtctgct ggctaacagg
    14521 acgtttatat tacaatctta tagaatatat agagagttac acacatcata aatgttccga
    14581 aatcaggcat gtatacagta ggtgttcaaa acgggatttt atatgaacaa gaaagactta
    14641 atattaaata ttcttttatt tattagtcaa ataatagtct tttattattt cttctgctat
    14701 ttattccctt ttaaggaaca gctacaaatg tttcaattta catcacagta cctaactgaa
    14761 acactaaagc aggctggtgg tgtcgctatt tatatatcgg aatttctctc tcaattctat
    14821 gtggtatttt ggacaggacc tatcatttct gctctacttt taactttagt ggctttatta
    14881 tcatcattaa tactgaaaaa gattaactca cgaaacgatt tacctcttat tttcctgtta
    14941 ccctggctat ctttactaat tattagttta gactatgatt attatgaaca aggaactatt
    15001 gcttatctat ttttattgct ttttctatgg ctatatacaa acataaaaac acgaataaaa
    15061 tttatttatg gcatttgtat cattcctatt ttatatggaa tagcaggtcc tatcgtacat
    15121 ttatttgcta tatcggcatt gttctttgag tttttaacca atggaaagaa aaaatatatt
    15181 agtattattt atttgttgat tgccgcactt tcagcaattg caggtactta cttaggatat
    15241 agtagaaatt taactttagc gtttttacca gaggcttatt gtaatccact acaaacagta
    15301 tccgggatat attatgcatg gtatgcatta cctatgacaa tgcttctggt tgcttatttg
    15361 aaacgataca aagaacccgt ttctctaaaa gggaaatgta tatgggaagg gacacaatgg
    15421 gcaatcatgt ttctattggt ctatcaaggt atctttcatt ttgggaaatt ggatgcacag
    15481 cattccatga agcaggacta tttgctccgg acggaacagt gggaccttgt tatcagtgaa
    15541 tttaatcatg atgtattgtc taaacgccga atgtgcggtt taaacttagc tttggcacat
    15601 aaaggccagc tttcagagag attgttagat tatcctcaac acggtattga aaccttgatg
    15661 ctacattggg atcagtcgat ctatacagca caactgcata gtgatctgta ttattgtatg
    15721 ggaataataa gcgcagcaca aaaattcgct tttgaagcgt ttgtcagttc tcgttcttcc
    15781 ggtaatccgc ggatgttgaa aaggctgata gagacaaatc tgataacagg gtcctatccg
    15841 attgcggata aatatattca attgttggaa aagacttggt actataagga ttgggctact
    15901 gctcaccgtc gatttcttta caatgataaa gcagtcgagg aagataaaat tttaggaatg
    15961 aaacgtcgct gttggaaggc cgaagcctct gctgcaaaac tatatacaga tcctgtcagt
    16021 tcattaataa acttgctccc ggcttgtccg gataataaag caggattagc atatttgact
    16081 tcgtttttac tgttgaacaa agatattgaa acttataaaa ccttgcagga gagcttgtac
    16141 cattctcccg cctggcgcga tatgacggaa tgccagcagg aggcaatcgt gatttgcagt
    16201 cccaatgatc cgcacttctg gttagagcat ggggtgagca tcaaagtaag gaacagagcg
    16261 atcgctttta tgcagaaagt gcaagata
//
