LOCUS       c00245_gnlPro..         3351 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HACOGPHE_245.
ACCESSION   c00245_gnlPro..
VERSION     c00245_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 09:57:02
            Original ID  :: gnl|Prokka|HACOGPHE_245
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3351
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..3351
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[749:3351]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      750..3351
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..3351
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..3351
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             136..372
                     /locus_tag="ctg245_1"
                     /transl_table=11
                     /translation="MTKLSNIPAKETTAKTAKTRKTKTGPAKLKWDPTKPMQFTQEEIW
                     EHIHEIEKGPFLTLDEGFKRFEAWKQDLLKSRL"
     CDS             339..680
                     /locus_tag="ctg245_2"
                     /transl_table=11
                     /translation="MEARPTQKQVITSSLFWESYDNVYVQGLDLFGFYQAELYANKIKS
                     ILYELDQTYPYYPECRHLATKSRMYRNIILDSHLIIYRITEERIEVLDIVHSASSMRKI
                     KKTKNIHIE"
     CDS             complement(750..1793)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg245_3"
                     /sec_met_domain="IlvN (E-value: 9.7e-48, bitscore: 150.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.3e-40, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYDKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(1843..2568)
                     /locus_tag="ctg245_4"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESDPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             complement(2575..3129)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg245_5"
                     /sec_met_domain="ALS_ss_C (E-value: 7.3e-18, bitscore:
                     53.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             complement(3145..3351)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg245_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.3e-10, bitscore:
                     28.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PDFVAIAKAYGIAGRAVEKREELDDAIAEMLNHDGAYVLVANVET
                     CGMVYPMVPAGGSVTNMIMGDEK"
ORIGIN
        1 ggcggggcat gccccgcctc tacaactggg taataagtta atcctataga cctacttttt
       61 tccttaccaa atatcttatt acatggaaat tattccatac atttgccaca gtactaatta
      121 ataacgatta cgactatgac aaaattaagc aacatccccg ccaaggaaac tacggccaag
      181 accgcaaaga cacgtaagac caagaccgga cccgcaaagc tcaagtggga tcctaccaag
      241 ccgatgcaat tcacccaaga agagatctgg gaacatatcc atgagattga gaagggaccg
      301 ttcctaaccc tagatgaagg ttttaaacgt tttgaggcat ggaagcaaga cctactcaaa
      361 agcaggttat aaccagtagt ttattttggg aaagttacga taatgtatat gttcaaggcc
      421 ttgacttatt tggattctac caagcggaat tatacgctaa caagataaaa tccatcttat
      481 acgagttaga ccaaacctat ccttattatc ccgaatgccg acacctagcc acgaaaagcc
      541 gcatgtaccg gaacatcatc ctagattcac accttatcat ctaccgcatc accgaggaac
      601 gcatcgaggt gctggacatc gtccattcag catccagcat gcgaaagatc aagaaaacaa
      661 agaatatcca catcgaataa cacaaagaaa ggcgagccac ccgtaagtga cccgcctctt
      721 tttgctgata tataaggatt aagattggat tagttgttct ccggacgaag cttgcgtaca
      781 gtaacagcag tctgccacat ctcgctctcg cgcaacgcct tcaattcagc ctccaatttc
      841 tcacgataat ccggcttaga gtttgagtcg atagagatct gagcctcgtt accgcatttt
      901 acgttcgcat acaatttctc gacaaccggc ttgattgcgt cgtggaacgg acccatccag
      961 tccaaagcgc cacgctgggc agtcgtagag cagttagcgt acatccagtc cataccattc
     1021 ttggcgaata agggcatcaa ggattgagtc aactcctcga ccgtctcgtt gaaagcctcg
     1081 gaaggagtat gtccattctc gcgcaatacc tcatactggg ccaacaacaa accttggata
     1141 gcgcccatca aagaaccacg ctcaccagtc aaatcggaag tagcctcacg gatgaaagtc
     1201 gtctcgaaca agtagccgga accgataccg atacccaacg ccaacgtacg atccatcgcc
     1261 ttgccagtag cgtcttgata gatagcgaaa gaagagttca agccacgacc ctcaaggaac
     1321 atggaacgca aagacgtacc agaccccttc ggagcgacca tgatcacgtc aatatccgca
     1381 ggaggaacaa cgcccgtacg atcgttccaa gtgatcgcga aaccatgaga gaaatacagg
     1441 gccttaccag ctgtcaaata aggcttcatc gtaggccata cagacattac ggcagcgtcg
     1501 gacaacaagc acatgatgat cgtggccttg tcgcaagcct cctcgatacc gaacagagtc
     1561 tcacccggaa cccatccgtc ctcaaccgct ttatcgtaag tcttaccttg gcgctggcca
     1621 acgattacgt tgaaaccatt gtcacgaagg ttcaatgact gtcccggtcc ctgtacgcca
     1681 tagccgataa cagcgattgt ctcatctttt aatatctctc ttgccttttc caacggaaat
     1741 tcctcgcggg tcattacatt ctctacaaca ccgccaaaat tcatttgtgc cattttcttt
     1801 ttaactatta atgtttaaaa acctatttat gtatctcttt tattatctcc aagtaaccgc
     1861 cgcacgacag atcgcctttc cctcatggca aatagccatg tcttgcttat cgggatcgga
     1921 ctccgcctta tgaagcgtaa gcggcatacc ttgtttaccc tcggattggt aggcgatctc
     1981 cagacggccg atctcacggg tcttgaactg gtcgatatcg aacaaatcca gcagatgctc
     2041 gatatacttc acgctattga agtgaccgtt gatatccaag tcgctgtatt tgatcgaata
     2101 cgggattccc tccgccttat tctccgccgg catgatcttg cccggcttct cgatcgggca
     2161 cggacgctcg tcgatatatt tgcccaatgc ctctatatcc aataaggtag gacggcgggt
     2221 ctccacgtcg atagccgccc aaatagaacg ggcgaatcca aaggttttcc cattctcatc
     2281 cgccagctcg aaacaacgac tggtgaagag gcgtccgacc tcatcgatcc aagtgtatag
     2341 attaatctta tcgaaggcgg taggatattc cttcatctcg atagccagac gggacaacac
     2401 ccaagccgta tgacgctccg acatatcatt gaaaccgaac ccacgctctc cggcatggct
     2461 ggaagcggcg tgaatcaaat agttaccaat catagggagc gttacacgtc ccctaaaatc
     2521 catcaaatac ggctccgcca cgaaatgaaa taatcctact ttctccatat cttattattg
     2581 ttgcttttca tgtaactttc gctccatatc ggccaacata tcgctcaagc gctccacctt
     2641 gctcttcgtg atagccacac gtccggagcg gatgaattgc aggacaccga tcgtctcgct
     2701 caactcattg aacaaggctt gtgtctcgtc atagtggcca ctcttctcca ataccacgca
     2761 ggtctcgttc atctccaaga tacgagcgtt gtatttacgg atcaatccct ccacggttcc
     2821 catcttgatg aaaagctcgg tacttagctt ataaagggcg atctcttgat aaaccagatc
     2881 ctcatccgta ttataataag ccttcaagat atccacacgt ttatcgatct gtttcaccac
     2941 cttatcgatc atatcctcat cggcgaatgt cgtgatcgta aacttatgga tgcccttgat
     3001 agcggacgga gagacggaca gagtctcgat gttcagctgt cggcgtgtaa agataatcgt
     3061 tatctggttc aaaagaccta cgatattctc tgaaaagata ataacggtat ataatttctt
     3121 tgttgtcata gcttcatctc ctccttattt ctcgtctccc ataatcatgt ttgtcacgct
     3181 tcccccggca ggaaccatcg gatataccat tccgcaagtc tccacgttag cgaccaacac
     3241 gtaagcgccg tcgtggttta gcatctcagc gatagcgtcg tccaattcct cccgcttttc
     3301 aacggcacgg ccggcgatac cataggcctt ggcgatcgcc acgaaatccg g
//
