LOCUS       c00278_gnlPro..        16241 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HACOGPHE_278.
ACCESSION   c00278_gnlPro..
VERSION     c00278_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 09:57:02
            Original ID  :: gnl|Prokka|HACOGPHE_278
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16241
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16241
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3405:6241]"
                     /cutoff="5000"
                     /detection_rule="(Fer4_7 and TPP_enzyme_C and POR and POR_N
                     and PFOR_II and not (EKR or Fer4_16))"
                     /neighbourhood="10000"
                     /product="porA"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3406..6241
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="(Fer4_7 and TPP_enzyme_C and POR and POR_N
                     and PFOR_II and not (EKR or Fer4_16))"
                     /neighbourhood="10000"
                     /product="porA"
                     /protocluster_number="1"
     cand_cluster    1..16241
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Fer4_7 and TPP_enzyme_C and POR and
                     POR_N and PFOR_II and not (EKR or Fer4_16))"
                     /kind="single"
                     /product="porA"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16241
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="porA"
                     /region_number="1"
                     /rules="(Fer4_7 and TPP_enzyme_C and POR and POR_N and
                     PFOR_II and not (EKR or Fer4_16))"
                     /tool="gutsmash"
     CDS             2..661
                     /locus_tag="ctg278_1"
                     /transl_table=11
                     /translation="VKLIITNYPEGQVEELEAINNPEDPEAGSHTIEFSRELWMEREDF
                     MEDAPKKYFRMTPGQEVRLKNAYIVKCTGCKKDENGEITEVYCEYDPNTRSGMPDANRK
                     VKGTLHWVSCAHCQKAEVRLYDRLWKVENPRDELAAIREEKNCSPLEAMKEIINPNSLE
                     IRKNCYVEKFVATLPKLSYLQFQRIGYFNIDSESTPDNLVFNRTVGLKDTWSKINK"
     CDS             672..2129
                     /locus_tag="ctg278_2"
                     /transl_table=11
                     /translation="MKKDDISRLLQHYLSAKEEGKEPYFDADQIDEMLDSFEDSNDYTY
                     FDEVLALGLKLHPGNSALQIKKGRQFAYNEDYESALALLENIAETDNQDLDMLKMECYC
                     SLNQYPKVLEITEELITRDCDYLEEVFEYISPILNDLDMNKEARDFVDRGLALFPDNLI
                     LKNELCYILETEGDVPRAIELCNELIDKNPFSYEYWFTLGRLHSMVGDYEKAIEAFDFA
                     LTCDDSDTELKILKAYCLYMNESYEKAIEEYQEIEGDEEVMRRISPLMAECYMKLEQYE
                     KAYQLLSTIINDPDMEDGPTNYINYIRCCTETERDNEASIMLFKAAQLYPNNVRLLSLL
                     ALCLLDSGKKEEAIAITNKIFKIIDKKSINPETQEECNSLLHAGQYLLSKGDVDKAISY
                     YKKVLQINPKTPMIHIHLAMAYLDNRDMENFMEHIGQISGDDLLYLLRKVGPEVFADFT
                     IDSDKEKKHIQPEDLVKEFLKNKDNSN"
     CDS             2147..3064
                     /locus_tag="ctg278_3"
                     /transl_table=11
                     /translation="MPNKRNLKDYGFLVLKGMGMGAADVVPGVSGGTIAFIVGIYEELI
                     DSIKSINGTTLKQLFTGKIAAFWKGINANFLLSIVGGIGISIFSLAKIITYLLVYHPIL
                     VWSFFFGLVLASTWFVSKDIKQWNWKTILSFVVGGVIAFYITVATPAETPSNLLFIFLC
                     GAIAICAMILPGISGSFILVLLGKYFYIMEAVKTFNVPVMLVFIAGAAIGITTFSRVLS
                     FALRKFHDITIAVLAGFMLGSLNKVWPWKETIETYVDSHGMTKPLVEANIAPNQFVWEA
                     VGLMILGFGIVYFLEKLSQKSAKA"
     CDS             complement(2971..3153)
                     /locus_tag="ctg278_4"
                     /transl_table=11
                     /translation="MGIVSSLQCPFKEGYNGHSNHLIMPIVILGYALALFCESFSRKYT
                     IPKPKIINPTASQTN"
     CDS             3406..3633
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg278_5"
                     /sec_met_domain="Fer4_7 (E-value: 2.3e-14, bitscore: 44.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 7.8e-08, bitscore: 22.2,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 7.3e-09, bitscore: 25.6,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.8e-06, bitscore: 18.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKIKGAVVVNTERCKGCNLCVVACPSDVLELHPREVNNKGYHYV
                     YMKNPDACIGCASCGLVCPDGCLTIYKVKI"
     CDS             3648..4727
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     POR_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg278_6"
                     /sec_met_domain="PFOR_II (E-value: 3.1e-28, bitscore: 88.3,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 5.3e-50, bitscore: 160.3,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEDIKLMKGNEAIAHAAIRYGVDGYFGYPITPQSEILETLMAEM
                     PWEKTGMVVLQAESEVAAINMVYGGAGSGKKVMTSSSSPGVSLKQEGISYIAGAELPCL
                     IVNVMRGGPGLGTIQPSQADYFQTVKGGGHGDYRLITLAPSSVQEMADFVGLGFDLAFK
                     YNNPAIILADGIIGQMMEKVVMPPYHTRRTEEEIITQCPWAVQGKKGGRKGNVITSLEL
                     DPAKMEENNIRFQAKYRKIEENEVRYEEFQCEDADYLLIAFGSSARICQKVVEIARAEG
                     IKLGLLRPITLWPFPTKVIAAYADKVKGMLSVELNAGQMVEDVRLAVNGKVKVEHFGRL
                     GGIVFTPDEVLNALKEKLF"
     CDS             4733..4903
                     /locus_tag="ctg278_7"
                     /transl_table=11
                     /translation="MTRGSKADEILTLVFMLLAIAAVVCYFAVSDKTVFLYCGGAAIVL
                     RLVQYVLRYIH"
     CDS             4916..5680
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg278_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-25, bitscore:
                     80.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNDIIKPENLVYEKPRLMNENPMHYCPGCSHGVIHKLIAEVIA
                     DMGLEDKTIGISPVGCAVFAYNYLDIDWIEAAHGRAPAIASAVKRLNPEKMVFTYQGDG
                     DLAAIGTAETIHAANRGENIVIVFVNNAIYGMTGGQMAPTTLEGMPTATCPYGRNIALN
                     GYPLKIGDLLAQLEGTCLVTRQSVQTAAAVRKAKKMLRKAFENAMAGKGTSVVEFVSTC
                     SSGWKMTPEKANKWMEANMFPFYPLGDLKNVE"
     CDS             5699..6241
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     POR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg278_9"
                     /sec_met_domain="POR (E-value: 3e-35, bitscore: 112.0,
                     seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQEIIIAGFGGQGVLSMGKILAYSGLMEGKEVSWMPSYGPEQRG
                     GTANVTVILSDERISSPVLNEYDIAIILNQPSMDKFESKVKPGGILIYDGYGIHTPAKR
                     TDINVYRVDAMDAATEMKNEKAFNMLILGGLLNIVPMVQLENVMLGLKKSLPERHHHLL
                     PMNEAAIKKGMEIIQKI"
     CDS             6259..8427
                     /locus_tag="ctg278_10"
                     /transl_table=11
                     /translation="VPICQLSFLIGILAYFIIGTLFFVISLQPMKYYLYILLFLIGTAA
                     SAHAQGRSGSRGGRGGFSLSNLSSSNKEIPDSLLQTDSAALKSKRIIGYRLTPLLGERY
                     IAPMDTNRLNFGNSTLVEANSLAVGYLANVGSPAQTRIFNERKEERDFIFADAYDYYIT
                     TPTNAYFYDTKVPYTQVTYTTGGASQNKMDRLKGVLTMNFGKKINVGGEMDYIYSRGYY
                     NSNGNKLLSYRFFGSYITDRYELNAYLSNFNFVNYENGGLTNDQYITNPDDLAENQRNI
                     DSKSYPVRYTDTWNRVRGKQYFLTQRYNLGFTKELEETDEEGNIKEVFIPVSSIIHTID
                     YEDNRRRFISNDAGIDTCYTHLYGMDASLNDQTSSWNLKNTFALALREGFQDWAKFGLT
                     AFVTFEKRRFRLASQVPGLDYGPDGRGSSEPSTLNFPTSEVYDEFTTYIGGELSKRRGS
                     LLTYNVRGELGLAGSDAGEVRVSGDLQTKFKLFKKDATIKAEGYIKNITPAFYQRHHHG
                     RYYWWDLSLKNVQRIYAGAKINLESTRTQLSGGVESIQNYVFFNGKGLPEQSSKNIQVV
                     SARIKQDIMYRAFGWENEVAYQLSSEKSQLPLPDISAYSNIYLAFKLAKVLTVQIGANV
                     YYNTAYYAPYYEPATQQFQVQEEDKKVKVGNYPLINAYANFHLKQARFFIMAYNLGSKF
                     VDPNYFSLAHYPLDPMVLKMGISVTFNN"
     CDS             8437..9261
                     /locus_tag="ctg278_11"
                     /transl_table=11
                     /translation="MRSKKLLILYAFLLIVAVTTMIQLWRFNQRPQEIGPRDYPEIKEE
                     GILRMITEYNQSGYFVSGDTVQGFQYELSQAIAKLSGLEVQTHLEMSLAKSFEELSDNK
                     CDVIARNIPITSEMRENYLFTEPIVLNKQVLVQRTAEANNGQAPIRNQLDLAQKTLYIP
                     KDSPALLRLQNLGHEIGDTIYVVEDELYSTEQLMIMVAKGDIDYAVCDQQIARMTQKNL
                     PEVDILTDVSFTQLQSWAVRKDSPVLLDSLNSWLQQIKNSGLYDQIYKRYYK"
     CDS             complement(9264..11132)
                     /locus_tag="ctg278_12"
                     /transl_table=11
                     /translation="MNSLESGSNVQSGLEMIMEKSPDTIVLVDRNLTLVKVISAKDDYY
                     HYLANNCIGKQPQALFPDGKNYDQYEIYRAAVKRVFEEQVKVDFSFEVSFEGKNYYYLS
                     QASLFNEELVIVYTCDVSSLKTEKNLQELINTILDRLPLGVFVKDGDNHFNYLYWNHFM
                     EEITGIETREIEGHDDFEVNYNALMTAEERLETDMNVIKTGLTARFKGKVKSASGDYRD
                     IEVAKYPISLNNGKPLVLALWRDITSELATENTLRRTRILTKMALRISDIRTCSIFIDP
                     DCTHNFKDSVVTLNDWNTMSEDMIEVSWGQFISRAHPDDQEHYHNMFTRLCRGEISEAR
                     IEARMLFPGKKEYVWREVFATVYERDEKGRPSVILGCSTNIQERKNQELSLEEAKVKAE
                     AADKMKSKYLADMSHEIRTPLNAITGFSELMAFADTDEERMSYYDVIKMNNQLLMQLIN
                     DILDISKIEADAIKITYEQLDVSELMDTIYASAKLRVPGGVKLILEKGADHHMFGTDSM
                     RLLQLINNLVNNAIKNTKEGSITMGYTIQPDNQLRFYVRDTGIGIDKDKLKDVFGRFVK
                     INDYMEGIGLGLAICKGLVVKMGGSIHVTSELGVGSEFSFILPSHE"
     CDS             11149..12549
                     /locus_tag="ctg278_13"
                     /transl_table=11
                     /translation="LGYNSGIKVFIFLFITKEKPTYCIIFLNNLYLYREFECKKMRFDE
                     LDLEDAVLDGLYDMNFDETTPVQELTIPVILEGKDIIACAQTGTGKTAAYVLPVINELS
                     KGCHPTDAVNAVIMAPTRELAQQIDQQIQGFTYFIPSVSAVAVYGGTDGIAWEQQKRGL
                     EMGADIVIATPGRLLSHIKLGTVDLSKVSFFVLDEADRMLDMGFYDDIMQVHKQLPPYC
                     QTIMFSATMPPKIRTLAKTILKDPEEVKIAISRPPESIMQTAYICYDPQKLKILQDLFT
                     QSRPQRVIIFSSSKMKVKELASTLKRLKFNVAAMHSDLEQSQREEVMKEFKSGHIDILV
                     ATDVVARGIDINDIKLVVNFDIPHDPEDYVHRIGRTARGTNGEGLAITFVSIDEQAQFK
                     RIEDFLEKEVYKIPVSPEFGEVPLYEPEKYGMNKRGRGRPRKSEDKGSSSSPQKRNMGH
                     RGRPKKAQ"
     CDS             complement(12646..14622)
                     /locus_tag="ctg278_14"
                     /transl_table=11
                     /translation="MQKYNILELNEKLLPELQSIAEELGIKKVSSLKKEELVYRILDEQ
                     AISYAGIQAEKMKEKEAKKPAEGRKRGRPAKSPKVAKAETAETAESTQQAPEKLVTAPA
                     DKKEQKEQPERKKRVRIEKKEKVAGAIAPSEDNKEVVVSKEPQTISTVTEISAVETPAV
                     AESPVEKPLLPPVVAELETEEEAALPENTTPVEVAEETTSPQATEEEPKRIVFRHPDAK
                     SVLDQIFPFSAPKPEANKPQPEAAPQQNNPRQNNRQNNHNNNRNNNNANNNQQAQEKMY
                     EFDGILTGTGVLEMMQDGYGFLRSSDYNYLTSPDDIYVSQSQIKLFGLKTGDVVEGSIR
                     PPKEGEKYFPLVKVDKINGRTPEEVRDRVPFDHLTPLFPDEKFMLTARKSPKVYDNIAV
                     RVVDLFSPIGKGQRGLIVAQPKTGKTMLLKDIANAIAYNHPEVYMIILLIDERPEEVTD
                     MARSVDAEVIASTFDEPAERHVKIAEIVLNKAKRMVECGHDVVILLDSITRLARAYNTV
                     QPASGKVLSGGVDANALQKPKRFFGAARNIENGGSLTILATALTETGSKMDDVIFEEFK
                     GTGNMELQLDRKLSNKRIYPAVDITASSTRRDDLLQDESTLNRMWVLRKYLSDMNSMEA
                     MEFVKQRMEQTVDNMEFLASMNG"
     CDS             complement(14824..16140)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP_bind_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg278_15"
                     /sec_met_domain="ATP_bind_3 (E-value: 8.2e-48, bitscore:
                     152.6, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHTIRLYIEKYRLLSEDRPVLVGLSGGADSVALLGVLVRLGYPC
                     IALHCNFHLRGEESDRDEAFACEFAESLEVPFHKIDFDTISYAGEKHLSIEMAARELRY
                     AWFEEMRERLGGQAIAVAHHRDDNVETVLMNLIRGTGIRGMSGIRPRNGFIVRPLLCVS
                     REDILAWLADQGYAYMVDSTNLSDAYTRNFIRLNVLPLLEEINPSARNTIARSAEHLSA
                     AETIYIYVLEQARKEVVVSDDRLSIGALMRFPAPETILYELLKEYGFTRLVSDDIFAAL
                     TKEPGKLFYSSTHRLLKDRDYLWITSLEKKEERTFVLDPEKGINHEPIELSFQKLVITI
                     GFPIEKNKRIAYLDYDKLDFPLTLRTWKEGDWFIPFGMKGRKKLSDYFSDHKFSRIEKE
                     RTWLLCSGDAIVWVVGERTDNRFRIDESTKRVLIVNFLG"
ORIGIN
        1 ggtgaaactg attatcacca actatccgga aggacaggtg gaggagctgg aagcgatcaa
       61 caacccggaa gatccggaag ccggcagcca tacgatcgag ttcagccgtg agttgtggat
      121 ggaacgtgag gatttcatgg aagacgctcc caagaaatat ttccggatga caccgggaca
      181 ggaagttcgt ctgaagaacg cctatatcgt aaaatgtacg ggctgtaaga aagacgagaa
      241 cggtgagatt accgaggtat attgcgaata cgatccgaat acccgcagcg gtatgccgga
      301 cgctaaccgt aaagtaaaag gtaccttgca ctgggtaagc tgcgcccatt gccaaaaagc
      361 ggaagtacgc ttatacgacc gcctttggaa agtggagaac cctagagacg aattggccgc
      421 tatccgggag gagaagaatt gctccccgct agaggcgatg aaggaaatca tcaacccgaa
      481 ctccttggag atccggaaaa actgttacgt agagaagttc gtggctacct tgcccaagct
      541 ttcctacctt caattccagc gtatcggcta tttcaacata gatagcgaat ccacccccga
      601 caacttggta ttcaaccgta ccgtaggact aaaggacacg tggagcaaga ttaataaata
      661 aagaatagta aatgaaaaaa gacgatatct cacgcttgtt acaacattat ctttcagcga
      721 aggaagaggg taaggagcct tatttcgacg ctgatcaaat cgatgaaatg ttggacagct
      781 ttgaagattc gaacgattat acttactttg atgaagtctt agccctcggg ctaaagcttc
      841 atcccggtaa ttccgccttg caaatcaaga aaggcaggca attcgcgtat aacgaggatt
      901 atgagagcgc tctcgctctg ctcgagaata tagcggagac tgataaccaa gatctggata
      961 tgttaaaaat ggaatgctat tgctcgctca accaatatcc caaggttctg gagatcacgg
     1021 aagagttgat cactagggat tgtgactatt tggaggaagt cttcgagtac atctccccca
     1081 tcctgaatga tttagacatg aacaaagagg cccgcgattt cgtggaccgt ggcttggctt
     1141 tatttccgga taacttgatc cttaagaatg agctttgcta catcctcgag acggaaggag
     1201 acgttccccg ggcgatcgag ttatgtaatg agctaatcga taagaatcct ttctcatacg
     1261 agtattggtt tacgctggga aggctacatt ccatggttgg cgattacgag aaagcgatcg
     1321 aggctttcga cttcgccttg acgtgtgatg attccgatac ggaactgaaa atattgaaag
     1381 cgtactgcct gtatatgaac gagagctatg agaaggcgat cgaggaatat caagaaatcg
     1441 agggtgatga ggaggtgatg cgccgtatct ctccactcat ggcggaatgt tatatgaagc
     1501 tggagcaata tgagaaggct taccaactgc tttccacgat cataaacgat ccggatatgg
     1561 aggatgggcc gaccaattat atcaattata tccgttgttg taccgagact gagcgtgaca
     1621 acgaggcttc catcatgtta ttcaaggcgg cgcaattgta tccgaacaat gtccgtctcc
     1681 tttctctttt agcgctttgc ttgcttgata gcgggaaaaa ggaggaggct atcgctatta
     1741 cgaataagat attcaagatc atcgataaga aaagtatcaa tccggaaact caagaagaat
     1801 gcaacagcct gcttcatgcc ggacaatatt tgctttctaa gggagatgta gataaggcga
     1861 tctcttatta caagaaagtc cttcaaatca acccgaagac tccaatgatt catatccatt
     1921 tggctatggc ttatctggat aaccgtgata tggaaaattt catggagcat atcggccaaa
     1981 tatccggaga tgatcttctt tatttgcttc gtaaagtggg accagaagta tttgcggact
     2041 ttaccatcga ttccgataaa gagaagaaac atatccaacc cgaggatctg gtaaaagagt
     2101 ttttaaagaa taaagataac agtaattaga caattaataa tgtaatatgc ctaacaaacg
     2161 aaatctcaag gactacggtt ttttagtatt aaaaggtatg ggtatgggag cggcggatgt
     2221 cgttcccggc gtgtcgggag gaacgatcgc ctttatcgta ggtatctacg aggaactgat
     2281 cgactctatc aaaagtatta acgggacgac attgaaacaa ttattcacgg ggaaaatagc
     2341 ggccttctgg aaagggatca acgctaattt cttgctttct atcgtgggtg gtattggtat
     2401 tagtatattc tccctagcga agatcattac gtatctcttg gtgtatcatc cgatcttggt
     2461 atggtctttt ttctttggtt tggtgctggc ctctacttgg ttcgtctcta aggatatcaa
     2521 gcaatggaac tggaagacga tcttgagttt tgttgtcggg ggagtgatcg ctttttatat
     2581 caccgtggcg actcccgccg agactccgag taatttactc tttatcttcc tctgtggggc
     2641 gatcgctatt tgcgccatga tcttgccggg tatctcgggt agctttatct tagtgttgct
     2701 cggaaaatac ttctatatca tggaggcggt caagacgttt aacgttcccg ttatgttggt
     2761 gtttatagcg ggtgcggcta ttggtatcac gacgttctcc cgcgtgttgt cattcgccct
     2821 tcgtaaattc catgatataa cgatcgccgt attggccgga ttcatgttgg gttcgcttaa
     2881 caaggtatgg ccttggaaag aaacgatcga gacctatgtg gatagccatg gcatgaccaa
     2941 gccgttggtt gaggcgaata tcgctccgaa tcagtttgtt tgggaggccg tcggattgat
     3001 gatcttaggt ttcgggatcg tatatttcct agaaaagctc tcacaaaaaa gcgctaaggc
     3061 gtaacccaat attacaatgg gcattataag gtgattagaa tgcccattgt aaccttcttt
     3121 gaatgggcat tgtaaagagc ttacgatgcc cattgttatt tacctacatt ttatcatcgc
     3181 acatcgtact tttccaataa gcgaaatcct ctccatacca attaagtgat aaagaagcat
     3241 caaaagtaac tataaccgta ccctgaccgc cgaggcttta aatatcagta gaaagacgct
     3301 attcaacaaa atgaaacgtt ataatcttgg caacgagtaa ttttttacta actttgatgc
     3361 ctcaatagaa atgtgttaca tttagatttt aaataaacaa gtattatggc gaaaataaaa
     3421 ggagctgttg ttgtaaacac agagcgctgc aagggatgta acctttgtgt agtagcctgc
     3481 ccgtcggatg tactggagtt gcacccacga gaagtaaaca acaaggggta tcactatgtg
     3541 tacatgaaga acccggacgc atgcatcggt tgcgctagtt gcgggttagt ttgtccggac
     3601 ggttgtctaa cgatctacaa agtaaaaata taaagttata tcaagatatg gcagaagata
     3661 taaaattaat gaagggtaac gaggccatcg cccatgcggc tatccgctat ggcgtggacg
     3721 gttacttcgg ctatccgatc actccgcagt cggagatatt ggaaaccctt atggcagaga
     3781 tgccgtggga aaagaccggc atggtagtct tacaagcgga gagcgaggta gccgctatta
     3841 atatggtata cggcggagcc ggctccggaa agaaagtgat gacctcttct tccagtccgg
     3901 gcgtgagctt gaaacaagaa ggtatttctt atatcgcagg agcggagctt ccttgtctga
     3961 tcgtgaacgt tatgcgtggc ggtcccggat taggaacgat ccagccgagt caggctgatt
     4021 atttccagac cgtgaaaggc ggtggccatg gcgattaccg tttgattacc ttggcaccct
     4081 cttccgtaca agagatggcc gatttcgtag gccttggttt tgatctggct ttcaaataca
     4141 ataaccccgc tattatcttg gcagacggta tcatcggaca gatgatggag aaagtggtta
     4201 tgcctcccta tcatacccgt cgtaccgagg aagagattat cactcaatgt ccttgggccg
     4261 tacaaggaaa gaagggcgga cgcaaaggta acgtcatcac ttccttggag ctagacccgg
     4321 cgaagatgga agagaacaat atccgtttcc aagcgaaata tcgcaagatc gaggaaaacg
     4381 aggttcgtta cgaggagttc caatgtgagg acgctgatta tctattgatc gcgttcggtt
     4441 cttccgcccg tatttgccag aaggtagttg agatcgcccg tgcggaaggt atcaagcttg
     4501 gcttgttacg cccgatcacg ttatggccgt tcccgacaaa agtgatcgcc gcttatgcgg
     4561 ataaggtaaa aggtatgtta tcggttgagt tgaacgccgg acagatggta gaggacgttc
     4621 gcctagccgt aaatggtaag gtgaaggtag agcactttgg ccgattgggt ggaatcgtat
     4681 tcaccccgga tgaggtattg aacgcgctga aggaaaaatt attctgatcc gtatgacacg
     4741 aggaagtaaa gctgacgaga tattgacgct ggtctttatg ctactggcca tagctgccgt
     4801 ggtatgttac ttcgctgtta gcgataagac cgtattcttg tattgcggtg gagcggcgat
     4861 cgtattgcgg ctggtgcaat atgtcctaag atatatacat taataattaa agattatgga
     4921 actcaacgat ataattaaac cggaaaatct ggtgtatgaa aagcccagat tgatgaatga
     4981 aaatcccatg cactactgcc ccggttgcag ccacggtgtg atacataagc taatcgccga
     5041 ggttatagcc gatatgggtc tggaagataa gacaatcggt atctcccccg tgggatgtgc
     5101 cgtattcgca tataactact tggatatcga ttggatcgag gcagcccacg gacgtgcgcc
     5161 agccatcgct tccgccgtta aacgcttgaa tccggagaag atggtattca cgtatcaagg
     5221 agatggtgac ttggcggcta tcggtacggc cgagacgatt catgcagcca accgtggcga
     5281 gaatatcgtg atcgtattcg taaataacgc gatctatggt atgaccggcg gacagatggc
     5341 tccgactaca ttggaaggta tgcccacagc tacctgtcct tacggacgta acatcgcctt
     5401 gaacggttac ccgctgaaga tcggtgattt attagcccaa ttggaaggaa cttgcttggt
     5461 aacacgccaa agcgtacaga cggccgcggc cgtacggaaa gcgaagaaga tgcttcgtaa
     5521 ggctttcgag aacgctatgg ccggtaaggg tacttctgtg gtagagttcg tctccacttg
     5581 ctcatccggc tggaagatga ctccggaaaa agccaataaa tggatggaag cgaacatgtt
     5641 ccccttctac ccgctgggcg acttaaagaa tgttgaataa gtaatacggt aaacgacaat
     5701 gaaacaagaa ataattatag caggcttcgg tggacaaggt gtattgtcta tgggtaagat
     5761 cttggcctat tccggtttga tggaaggcaa ggaggttagc tggatgcctt catacggacc
     5821 tgagcaacgt ggcggtacgg ccaacgtaac cgttatcttg agcgacgagc gtatcagctc
     5881 acccgtattg aatgaatatg atatcgctat tatcttgaac caaccttcca tggataagtt
     5941 cgagagcaag gtgaaaccgg gtggtatctt gatttacgat ggttatggca tccatacgcc
     6001 ggcgaaacgt acggatatta acgtatatcg ggtagatgcc atggacgccg ctaccgagat
     6061 gaagaacgag aaggcattca atatgttgat cttaggcggg ttacttaata tcgtcccgat
     6121 ggttcaattg gagaacgtca tgctaggatt gaagaaatcc ttgcccgagc gtcaccatca
     6181 tttgttgccg atgaacgagg ctgccattaa gaaaggaatg gagattatac agaaaatata
     6241 agaagctcat tcattgatgt gccgatatgc caattaagtt ttctgattgg catattggca
     6301 tattttataa ttggcacatt attttttgtt atatctttgc aacccatgaa gtattatcta
     6361 tacatattac tttttctgat aggaacggcg gcttccgcgc atgcgcaagg acgttccggg
     6421 agccggggag gacgaggtgg attctcgtta tctaatttat catcctcaaa caaggaaata
     6481 ccggatagct tgctgcaaac agatagcgcg gcgctgaaat caaaacgaat catcggttat
     6541 cggctcacgc ctcttttggg agaacgttat atcgctccta tggataccaa tcgattaaat
     6601 ttcgggaata gtacgttggt ggaagcgaac tcattggccg taggttatct ggcgaatgtg
     6661 ggatcgccgg cgcaaacccg tatttttaac gaacgtaagg aggaacgtga tttcatcttc
     6721 gccgatgcct atgattatta tatcacgacc ccgacaaacg cttatttcta tgataccaaa
     6781 gtaccctata cccaagtgac ttatacgaca ggaggagcta gccagaataa gatggaccga
     6841 ctgaaagggg tactgaccat gaactttggc aagaagatca atgtcggtgg cgagatggat
     6901 tatatctata gccgcggata ttataactcc aacggtaata aattattaag ttatcgtttt
     6961 ttcggaagtt atatcaccga ccgttacgag ttaaacgctt atttaagtaa tttcaatttc
     7021 gtaaactacg agaacggtgg acttacaaat gaccagtata tcacgaatcc cgatgacttg
     7081 gccgagaatc aaagaaatat cgatagtaaa tcataccctg tccgttacac ggacacatgg
     7141 aaccgtgtcc gtggaaaaca atatttcctg acacagagat acaatctcgg ttttaccaaa
     7201 gaattggaag aaaccgatga ggaagggaac ataaaagagg tattcattcc ggtttccagt
     7261 atcatccata ccatcgatta cgaagataac cgcagacgct ttatctctaa tgatgccggg
     7321 atcgatacct gctacactca tctttatggt atggacgcat ctttgaatga ccagacttcc
     7381 tcctggaatt taaagaatac ttttgcgttg gccttgcggg aaggtttcca agattgggct
     7441 aagtttgggc tgaccgcctt cgttactttc gagaaacgcc ggtttagatt ggcatcccaa
     7501 gttcccggac tggattacgg tccggatggt cgtggaagct ctgagccgag tacattaaat
     7561 ttccctactt ccgaggtata tgatgagttt acgacctaca tcggaggcga attatccaaa
     7621 cgccgtggta gccttcttac ctacaatgtc cgtggagaat taggacttgc gggaagtgac
     7681 gccggagagg ttcgagtgag cggagactta cagaccaaat tcaagctttt caagaaagac
     7741 gctaccatca aggcggaagg atatatcaag aatatcaccc cggcgtttta ccaacgtcac
     7801 catcatgggc gttactattg gtgggatcta tcattgaaaa atgtgcaaag gatttacgcc
     7861 ggagcgaaaa tcaacttgga atccacccgt acccagttat ccggaggagt ggaaagtatc
     7921 cagaattatg tattcttcaa cggcaaaggt ttgccggagc aaagcagtaa gaacattcaa
     7981 gttgtctcag cccgtatcaa gcaagatatc atgtaccgtg cgttcggatg ggagaatgag
     8041 gtggcctatc agctttctag cgagaagtct caactcccgt taccggatat cagcgcatac
     8101 tcgaatatat atctagcgtt taagttggcg aaagtattaa ccgtacagat tggcgcaaac
     8161 gtatactaca acaccgctta ttacgctcct tattacgagc cggctaccca gcagttccaa
     8221 gtacaggaag aagacaagaa agtgaaggtt ggcaattatc cgttgatcaa cgcttatgcg
     8281 aatttccatt tgaagcaagc tcgcttcttc atcatggcat acaatctagg ctctaagttc
     8341 gttgacccga attacttctc tcttgcgcat tatccgttgg acccgatggt cttgaaaatg
     8401 ggcatctccg tgactttcaa taattaatcg attgccatga gatctaagaa gttgcttatc
     8461 ctatacgctt ttctactgat tgtcgctgta acgacaatga tacagctttg gagattcaac
     8521 caacgtcctc aagagatcgg acctcgtgat tatccggaaa tcaaggaaga aggaattctc
     8581 cggatgataa ccgaatacaa tcaatccggg tatttcgtat caggcgatac agtgcaaggt
     8641 tttcaatacg agcttagcca agcgatcgct aaattatccg gattggaggt tcagacgcat
     8701 ttggaaatga gtttagcgaa aagtttcgag gaattatcgg acaacaaatg cgacgtaatc
     8761 gcaagaaaca tccccatcac ctccgagatg cgggaaaact acctgttcac cgaaccgatc
     8821 gttctcaaca agcaagtctt ggtacaacgt acggcagagg cgaacaacgg acaagcccct
     8881 atccgtaacc aattggattt agcccaaaag actttataca taccgaaaga ttccccggcc
     8941 ttattgcgtc tgcaaaatct gggacacgag ataggcgata cgatctacgt ggtggaagat
     9001 gagttatatt ctaccgagca gcttatgatc atggtagcca aaggcgatat cgattatgcc
     9061 gtatgcgacc aacaaatcgc tcgcatgacc cagaaaaacc tgccggaagt cgatatccta
     9121 acggatgtca gttttaccca attgcaatcg tgggcggtcc gtaaagactc ccctgtccta
     9181 ctggatagcc taaatagttg gctccagcaa atcaagaaca gtggattata cgaccaaatt
     9241 tataagcgct attacaaata gcgctattcg tgagacggca aaataaagga gaactctgaa
     9301 cctaccccta attcagaagt aacatgtatc gaacctccca tcttaacaac taatcctttg
     9361 cagatagcca gtcctaatcc gataccttcc atatagtcgt ttattttcac gaaacgaccg
     9421 aagacatctt tcaatttgtc cttatcgata ccgattcccg tatcccttac gtaaaaacgt
     9481 aattgattat ccggttgaat ggtatatccc atcgtgatgc taccttcttt cgtgttcttg
     9541 atagcgttgt tcaccaaatt attaatcaac tgcaacagac gcatgctatc cgtaccgaac
     9601 atatggtggt cagccccttt ctccaaaatc aacttgactc ctcccggaac ccgtaacttg
     9661 gcggaagcat aaatcgtatc catcaattca ctgacatcta attgctcata tgtgatcttt
     9721 atcgcatccg cctcgatctt cgagatatcc aagatatcat taatcaattg catcaacaat
     9781 tggttattca tcttgatcac atcgtagtac gacatacgtt cctcatccgt atcagcaaaa
     9841 gccatcaatt cagagaagcc ggtaatcgca ttcaaaggag tccggatctc atggctcata
     9901 tccgccagat atttcgattt catcttatca gcggcctcgg ccttcacctt cgcctcctca
     9961 aggcttaatt cttgattctt ccgttcctga atattcgttg aacatccaag gataaccgaa
    10021 ggtcttcctt tctcgtcccg ttcatacacg gtagcgaata cctctctcca aacatattcc
    10081 ttcttgccgg gaaatagcat acgtgcctcg atccttgcct cagagatttc ccctcggcaa
    10141 agacgggtaa acatattatg ataatgttct tgatcatccg gatgcgcccg gctgataaac
    10201 tgcccccatg acacctctat catatcttcc gacatggtat tccaatcgtt caaggtcaca
    10261 acggaatcct tgaaattatg ggtacagtcc ggatcgatga agatcgagca tgtacgtata
    10321 tcacttatcc gcaatgccat tttcgtcaag atccgggttc ttctcaaagt attctccgta
    10381 gccaactcgg aagttatatc tctccataaa gccaagacaa gcggcttgcc attatttagg
    10441 gaaataggat atttagcgac ctctatatcc cggtaatcgc cggaggccga ttttaccttg
    10501 cccttgaatc tagcggtcag tcctgtcttg atcacgttca tatcggtttc cagacgctcc
    10561 tcggcagtca tcaaggcatt ataattcacc tcgaaatcat catgtccctc gatctcccgg
    10621 gtttcaatac ccgttatttc ctccataaaa tgattccaat acaggtaatt aaaatggtta
    10681 tccccatctt tcacgaaaac ccccaacggt aaccgatcta atatcgtatt gatcagttct
    10741 tgtagatttt tttctgtttt cagagaagat acatcgcacg tataaacgat cacaagctcc
    10801 tcattaaaaa ggcttgcttg cgatagataa taatagttct ttccttcaaa agagacctca
    10861 aaagagaaat ccactttcac ttgctcctcg aaaacacgtt taaccgcagc tctatagatc
    10921 tcatattgat cgtagttctt cccgtccggg aacaacgctt gaggttgctt tccgatacag
    10981 ttattcgcta aataatgata ataatcgtct tttgcagaaa taaccttgac aagagtaaga
    11041 tttcgatcta ctaatacaat cgtatcggga ctcttctcca tgatcatctc taatccagac
    11101 tgaacgttac ttccgctttc tagactattc atattaattc tttcgttttt ggggtataac
    11161 tcggggataa aggtatttat ttttctattt atcaccaaag agaaacctac ctattgcata
    11221 atatttctaa ataatcttta tctttaccgg gaatttgaat gtaaaaagat gagatttgat
    11281 gaattagatt tggaagatgc cgtattagac gggctttatg acatgaattt tgacgaaacg
    11341 actccagtcc aagagttaac gattcctgtc attttagaag gtaaagacat catcgcttgc
    11401 gcacagaccg gaaccggtaa aacggcggcg tatgttttgc cagttattaa tgaactaagc
    11461 aaaggttgtc atccgacaga cgcggtgaat gcggtcatta tggcaccgac ccgggaattg
    11521 gctcaacaaa tagaccaaca aattcaagga ttcacttatt ttataccttc cgtatccgca
    11581 gtagccgtgt atggaggtac cgacggaatc gcttgggaac aacaaaagag aggtttagag
    11641 atgggtgcgg atatcgtgat cgctaccccg ggacgtttat tgtcccatat taagttaggt
    11701 actgtagatt tgtctaaagt gtcgttcttc gtcttagacg aggcggaccg catgctggat
    11761 atgggttttt atgacgacat catgcaggtt cataaacagc tgccccccta ctgccagacg
    11821 atcatgttct cggctaccat gccgcctaag atccggacgt tggctaaaac catcctaaaa
    11881 gatccggaag aagtcaagat cgctatctca cgcccacccg aatctatcat gcaaaccgca
    11941 tatatctgct acgatccaca aaagctcaag attctacaag atctcttcac tcaaagccgc
    12001 cctcaacgag taattatctt ctcctcttct aaaatgaagg tgaaagaatt agcgtctacc
    12061 ttaaaaagat taaagttcaa tgtagccgcc atgcactcgg atctagagca atcccaaagg
    12121 gaggaggtca tgaaagaatt caagagcgga catatcgata tccttgtggc tacggatgtc
    12181 gtagcacgtg gaattgatat caatgacatc aagttggtcg tgaacttcga tatcccgcat
    12241 gatccggagg attacgtaca ccgaatcgga cgtacggcac ggggtacgaa cggcgaagga
    12301 ttggcgatta ctttcgtatc gatcgacgaa caagcacaat tcaagcgcat agaggatttc
    12361 ttggaaaaag aggtttataa gataccggtc agcccggaat tcggtgaagt gcccttgtat
    12421 gagccggaaa aatacggtat gaataaaaga ggcagaggac ggcctcgtaa aagtgaggat
    12481 aaaggatcat cctcgagccc acaaaaacga aatatgggac atcgtggaag gcctaaaaag
    12541 gcgcaataaa agcactatac tttttatttg aaaaacacta tacttttgga gctaaaacaa
    12601 tattgctttg aactcaaaag tatagtgttt ttttatggga tattatcaac cgttcatgga
    12661 tgccaagaat tccatattat caacggtttg ttccatccgt tgcttaacaa attccatagc
    12721 ctccatagag ttcatgtctg atagatattt gcgtaagacc cacatacggt tcaacgtgct
    12781 ctcatcctgc aataaatcat cacggcgagt gctggaagcc gtgatatcca cagccggata
    12841 gatacgctta ttggataatt tacgatccaa ttgtaactcc atattacccg tacccttgaa
    12901 ttcctcgaag atcacgtcgt ccatcttaga gccagtctcc gtaagggcgg tggctagaat
    12961 cgtaaggcta ccaccattct caatattacg ggcggcacca aagaaacgct tcggcttctg
    13021 caacgcattt gcgtccacac caccggaaag caccttaccg gaagccggtt gtaccgtatt
    13081 ataagcacga gccaaacgag tgatcgagtc cagaagaatc acgacatcat gaccacattc
    13141 taccattcgt ttcgccttgt tcaatacgat ctcagcgatt ttcacgtgac gttcagccgg
    13201 ttcgtcgaat gtagaagcga tcacttccgc atctacgcta cgagccatat ccgtaacctc
    13261 ctccggacgt tcgtcgatca ataatataat catataaacc tcgggatggt tgtaagcgat
    13321 agcgttcgcg atatctttca acaacatcgt cttaccggtt ttcggttgag cgacgatcaa
    13381 accacgttgc ccttttccga tcggggagaa taaatcaacc acacgtacgg cgatattatc
    13441 gtatactttc ggtgatttac gtgccgtaag catgaatttc tcatccggga ataacggggt
    13501 caaatgatca aaaggaaccc ggtcgcgaac ctcttccggc gtacgtccat tgatcttgtc
    13561 cactttcacc aacgggaaat acttctcacc ttccttcggc ggacggatcg aaccttctac
    13621 cacgtcaccc gttttcaagc caaataactt gatctgggat tgagagacat aaatatcgtc
    13681 cggtgaagtc aaatagttat aatctgaaga acgaaggaaa ccgtaaccat cttgcatcat
    13741 ctccaacacg ccggttcctg taaggatgcc atcaaactca tacattttct cttgagcctg
    13801 ctggttgtta ttagcgttat tgttattacg gttgttatta tgattattct gtcgattgtt
    13861 ctgtcgagga ttattctgct ggggagcggc ctcgggttga ggtttgttag cctcgggttt
    13921 cggagcggag aacgggaaaa tttgatccaa tacggattta gcgtccggat ggcggaatac
    13981 gatgcgctta ggctcttctt ctgtcgcttg tggagaagtg gtttcttccg ctacctctac
    14041 aggagtcgta ttttccggca aagcggcttc ttcttccgtt tcaagttccg ccacaacagg
    14101 aggcaacaac ggtttctcca ccgggctctc tgctaccgcc ggagtttcca cggccgagat
    14161 ttccgttacc gtagagatcg tttgcggctc tttcgaaacc accacttcct tgttatcctc
    14221 ggaaggagcg atagcgcccg ctaccttttc ctttttctcg atacggactc ttttcttacg
    14281 ttcaggctgc tctttttgct ctttcttgtc agccggagca gtcactagct tttccggagc
    14341 ctgttgggta ctctctgcag tttcggcagt ctcagccttc gccactttag gagatttggc
    14401 cggacggcct ctcttacggc cctctgcagg cttcttagcc tctttctctt tcatcttttc
    14461 agcctggatg ccggcatagg agatcgcttg ctcatcaaga atccgataaa ccaactcttc
    14521 tttctttaag ctgctaactt tttttattcc caactcttcc gcgatacttt gaagttcggg
    14581 aagaagtttt tcatttagtt ctagaatgtt atatttctgc atattgcgaa gtaataatat
    14641 aaatggtaca tacacacgga tcacatatac aaacacgatg tacgcccaat ggtatcattg
    14701 tatctttatt taattataat tttcatgtaa taaccggatt gttcagctaa tttgaaccat
    14761 tagtaacata tctgcggagt aaatcttcgc aaatgtaaga atatttttac aataaacgag
    14821 gatttagccc aaaaaattca caattagcac acgctttgtt gattcgtcta tacgaaaacg
    14881 attatcagtc ctttctccta ccacccaaac gatagcgtcg ccactacaaa gaagccatgt
    14941 gcgctccttc tcaatccggc taaatttatg atcggagaaa tagtcactca acttcttacg
    15001 tcctttcatt ccgaagggaa taaaccaatc gccttctttc caagtccgca atgttaaagg
    15061 gaaatcgagt ttatcataat ccaaataagc gatccgctta ttcttctcga tagggaaacc
    15121 tatagttata acaagttttt ggaaagatag ttcaataggt tcatgattaa tacccttttc
    15181 cggatctaaa acgaaggttc gctcttcctt cttctctaaa gaagtgatcc ataaataatc
    15241 ccgatccttc agcaaacgat gggtggaaga gtaaaacagc ttaccgggct ccttggtcaa
    15301 ggccgcgaaa atatcgtccg agaccagacg ggtaaaacca tattctttta ataactcata
    15361 caaaatcgtc tccggagccg gaaaccgcat caacgccccg atagaaagac gatcatccga
    15421 tacgacaacc tctttccggg cttgttccaa tacatatata tatatagtct ctgcggcaga
    15481 aagatgctcg gcggaacgtg cgatggtatt ccgggccgat ggatttatct cctccaaaag
    15541 cggcaacaca ttcaaacgga taaaattacg ggtataagca tccgataaat tcgtgctatc
    15601 caccatatag gcgtagcctt gatccgccaa ccaagccaag atatcctcac ggcttacgca
    15661 cagcaaagga cggacgatga aaccattcct cggacggatc ccgctcatcc cccggattcc
    15721 cgtgccccgt atcaaattca tcaagactgt ctccacatta tcgtcccggt gatgggcgac
    15781 ggcgatcgcc tgccctccca gccgctcccg catctcctca aaccaagcat agcgcaattc
    15841 acgggcagcc atctctatcg agagatgctt ctctccggca taagagatcg tatcgaaatc
    15901 tatcttatga aagggtactt ccaaagattc cgcgaactca caggcaaatg cctcatcccg
    15961 atccgactcc tccccacgca aatgaaagtt acaatgaagc gctatacacg gatatcccaa
    16021 acgcaccaat acgcccaaca aagccacaga atcggcacca ccgctcaatc cgaccaaaac
    16081 cggacgatcc tcggataaca gccggtactt ctctatatat aaacgtatcg tatgtatcat
    16141 aacatctttg tattaaaaac aataatggcc ctagccggtt ttagctagag ccattactta
    16201 tagatctttt gaattaatct tctacacctg ctaattccgg g
//
