LOCUS       c00313_gnlPro..        13690 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HACOGPHE_313.
ACCESSION   c00313_gnlPro..
VERSION     c00313_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 09:57:02
            Original ID  :: gnl|Prokka|HACOGPHE_313
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13690
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13690
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3690]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3690
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..13690
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13690
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(3..323)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg313_1"
                     /sec_met_domain="OAD_beta (E-value: 1.8e-24, bitscore:
                     76.4, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLTFLGENLQLFLTYTGVYNATPGHLIMIMVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMT"
     CDS             complement(328..759)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.8; E-value:
                     1.6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg313_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.3e-21, bitscore:
                     64.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIADVEVNGTPYQVKLEKPAKKQ
                     MVTLKRPAQAPTTASGDPVVTRPAASTTQGAVKTPLPGVILQVKCNVGDTVKRGQTLII
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             complement(781..1668)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg313_3"
                     /sec_met_domain="OAD_gamma (E-value: 4e-13, bitscore: 40.1,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLFALLISFGAKAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCYLTDDKNNPMKYPIPKGDVLTQIQPRQHSLFWADGEP
                     SRGTFHVNFVLDPFKENYIALYDADGKTLIDEVTIPAGQMADISYGRVIDGKDEWAQLK
                     KVTPSTNNLTLDSNEKIDNFKQNDSLGIGMTITAMAVVFLGLFLLYIIFKQIGRLSISA
                     SKRNAQKAAGTTSVSVDAGQESGEIFAAIATALYEMSDDNHDIEHTVLTIHKVQRTYSP
                     WSSKLYGLRQTPHK"
     CDS             complement(1690..3243)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg313_4"
                     /sec_met_domain="CT_Btheta (E-value: 1.4e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(3280..3690)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg313_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.8e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             complement(3819..6230)
                     /locus_tag="ctg313_6"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISVIYSCLGYNKAERIIPSAQADMRLNVQMNNTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKMFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYDP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKHNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPDDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRRVDKDKNGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYVM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRGFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             6352..6912
                     /locus_tag="ctg313_7"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEADSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKEAEE"
     CDS             6909..7676
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg313_8"
                     /sec_met_domain="F420_oxidored (E-value: 1.2e-09, bitscore:
                     28.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSHTSEHAKILADELG
                     CGWTVVPEDIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHTAGSMPISVFEGLTARY
                     GVVYALQTFSKSREVDFKKIPFFLEANSSEDEKVLGEVARALSSDVRFLSSEKRKNLHL
                     AAVFACNFTNHMYALAEKILEEQQIPGEVLLPLIDETAAKVHVMSPARAQTGPAIRYDE
                     NVINKHMAMLKDPDMRNLYELISRSIHKEARHE"
     CDS             7669..8190
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg313_9"
                     /sec_met_domain="HAD_2 (E-value: 5.8e-09, bitscore: 26.4,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLRKIKAFVFDVDGVLSCDVIPLHPNGDPMRTVNIKDGY
                     ALQLAVKKGYEVAIITGGYTEAVQIRFSRLGIQHIYMRSAVKVHDFKDFMEKTGLSPEQ
                     IMYAGDDIPDYEVMTRVGLPVAPADAAPEIKEIAKYISSRRGGEGVARDVIEQTMRAQG
                     HWFGEEAFGW"
     CDS             8228..8809
                     /locus_tag="ctg313_10"
                     /transl_table=11
                     /translation="MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRIIPDIDESYPDS
                     IDSMEIPLYIARSKAEAYKSTMADDELLITADTIVWTFDGVMGKPANREEAYAMLHALS
                     DHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWI
                     GYIGVEAINGSFYNVMGLPVQKLYQELKHF"
     CDS             complement(8812..9189)
                     /locus_tag="ctg313_11"
                     /transl_table=11
                     /translation="MKRYLNQLECKILRAGDSLFNTTTTDNLLIFVFSGKLIIYSQEGT
                     HIAEVAKDHFMLLAQNTNHKVIASAPTRLILIHAGSLSDMIINDPEWNVEKPVVLPIPP
                     ALAHTLNQIEYYMKDKYFTLN"
     CDS             complement(9198..10226)
                     /locus_tag="ctg313_12"
                     /transl_table=11
                     /translation="MRKNITILVSLLILSHTACSDKGQYFEESGSVFHTSYHIKYKAKQ
                     ILTDKIDSELQRFNLSLNPFNPNSTIAKVNNNEDVEVDEWFTEVFNKAEEISQKSGGAF
                     DITCAPLINLWGFGFSKMDSVTPQMIDSIKAFVGYQKVRLEGKKIIKEDPRILLNCSSI
                     AKGYACDVIARLLEKEGVKNYMVEIGGEVTMKGVNQQGDCWRVGINKPEIGTSGVTNDV
                     EEIVQLCQKGGVATSGDYRNFYIKDGKKYAHTINPATGYPAGQNILSATIVAEDCMTAD
                     AYATTFMVLGVEKAKLLAQSIPQIEYFIIYADNNGQQKVTYSKGMLEYLPNRKTLAILE
                     NP"
     CDS             complement(10252..11976)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ILVD_EDD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg313_13"
                     /sec_met_domain="ILVD_EDD (E-value: 5.9e-184, bitscore:
                     602.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGS
                     AHLDKLVDEAGIGIKEKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVK
                     ATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYE
                     RKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKET
                     ARKAGEHALGLAKEELKPSDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLS
                     PDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMEEIKEFLHLDVMTVTGKTLEE
                     NLKDLQLNGFYENCHKYLPALGVKVGDIIKPFHTPIKAQGAIAILKGNLAPEGAVVKHS
                     AISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAI
                     ASDPELVETIALITDGRFSGATRGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLD
                     IIGTDSIERSVEEIEKILSERRAHWIKPESQYKKGILDIYTHNSVSPMKGAYMEFFM"
     CDS             complement(12021..12587)
                     /locus_tag="ctg313_14"
                     /transl_table=11
                     /translation="MLYIEVLLLAIGLSMDSLAVSVTGGAVLKNNCTAGNIIKIASVLG
                     IFQAGMTVIGYTMGLGFEKYICAFDHWIAFTLLLYLGGKMIYDSAKEEEEDGKFDPLCN
                     RTLCGLGIATSIDALAVGISLAILKSPLLLQASTIGVVTFAISAFGVYFGNRFGKRIDL
                     KLDLIGGLILIGIGTKILIEHVFFS"
     CDS             complement(12589..13110)
                     /locus_tag="ctg313_15"
                     /transl_table=11
                     /translation="MSFLELARKRCSIRKYAPKNVEQEKIDYILEAARLAPSAVNYQPW
                     YFVWVQSAEGKAKLQECYPREWFKQAPYYLIVCGDHQQSWKRGDHKDHMDIDTAIATEH
                     ICLAAAEQGLGTCWVCNFDTELCRKHFKIPETIEPVVLIPFGYPSDPALFDETPKKRKP
                     IEEIIKRESF"
ORIGIN
        1 tcggtcatgg ccccgatacc gaggaagatc aatggcggat accatccaga ggtcacaccc
       61 tgatagagga tgttcagtac agacccttgc tcataaatac ctacctgaag acctgcgtcc
      121 ttgaaaggga tattaccgat caagatacca aatccgatag ggatcaaaag catcggttca
      181 aactcatatt taatcgccag gaatataaac aacagaccta ccataatcat gatgagatgt
      241 cccggagtag cgttgtatac acctgtatag gtaaggaaca gttgtaagtt ctcacctaag
      301 aatgttaaaa agctctcttg catagtctta tccgattact acgagatcag caccttctag
      361 cacagagtct cccttgtgta ctttaatttc tataatctta ccgtcacggt ctgcgttgat
      421 gttgttctcc atcttcatag cctcaaggat aatcaatgtt tgacctctct tcacggtatc
      481 acctacgttg cacttaacct gcaagataac acctggtagc ggagtcttaa cagcgccttg
      541 tgtagtagag gctgccggac gagtaactac agggtcgcca cttgctgttg tcggcgcttg
      601 agccggacgt ttcaatgtaa ccatttgttt cttcgccggt ttctctaatt ttacttgata
      661 aggtgtacca tttacttcaa catctgcgat gtcatccact acagaattga tgtgtacttt
      721 atatacgtta ccgttaatgg tatatttaaa acttttcatt ctttgttcgt ttttagataa
      781 ttacttatgt ggggtttgac gcaaaccgta gagttttgaa ctccaaggag aataagtcct
      841 ttgtaccttg tggatcgtaa gaaccgtgtg ctcgatgtca tgattgtcat cactcatctc
      901 gtacaaagcg gtagcgatag cggcgaagat ctcaccagac tcttgtccgg cgtcaaccga
      961 tacacttgtt gttcccgcag ctttctgagc gttacgtttg ctcgcggata tagacaatct
     1021 accgatctgt ttaaagatga tgtataacaa aaataatccc aagaacacta cagccatagc
     1081 ggtaatggtc ataccgatac ctaaagagtc attctgtttg aaattatcga ttttctcatt
     1141 agaatccaat gttaggttat tcgtactggg agtaactttc ttcagctgtg cccattcatc
     1201 tttaccatcg atcactctac cgtaactgat atcagccatt tgtccggcag ggatcgtaac
     1261 ttcgtcgatc aatgttttac catctgcatc atacagagct atataattct ctttaaacgg
     1321 gtctaatacg aagtttacgt ggaaagtacc ccgactcggt tctccgtccg cccagaacaa
     1381 tgagtgctgg cggggttgga tctgagttaa tacgtctccc ttcgggatcg gatatttcat
     1441 gggattgttt ttgtcgtctg tcaaataaca tcccgcgata tttaccgttc cggccgaagt
     1501 gttgaacaac tcaatccagc catgacgttt gccatagtca tcaacgaagt tatcctcgtt
     1561 gataaccaat acttcattaa tacgcatgga ggttgcgcgc tgtgcctttg ccccgaatga
     1621 aatgagcaaa gcgaacagta gcaatacccc tattttctta tttatcatat tcatctcctg
     1681 ttttacggat tatagaggca ggttatcatg tttcttagca ggattgctta acttcttagt
     1741 ctgcaattgc tgcaaagcac gaataatacg gaaacgagtg ttacgcggtt cgataacatc
     1801 gtcgatataa ccgtattgag ctgcgttata aggattagcg aatgctttct tatattcagc
     1861 ttctttctct gctgcgcatg ctttcggatc ttcagcggct gctacttcct tggcgaagat
     1921 aacctctacg gcaccgctcg ggcccataac ggcgatctcg gctgtcggcc atgcgtaatt
     1981 catatcacca cgtaaatgtt tagaactcat cacgcaataa gctccaccgt aagacttacg
     2041 caatgtaacg gtaatcttag gaacggtagc ctcaccataa gcgtaaagca atttagcgcc
     2101 gtgaaggatt acaccgttgt attcctgacc tgtacccgga aggaatcccg gaacgtcaac
     2161 caatgttacc aaaggaatat tgaaagcgtc gcagaaacga acgaagcgac ctgctttacg
     2221 agatgcgttg ctatccaagc atcctgccat aaccttcggc tggttggcta cgataccgac
     2281 ggattgtccg ttgaaacgag cgaaacctac gatgatattc ttagcgtagt ccgcatggac
     2341 ctctaggaac tcgttgttat cgacgattgt accgataacc tcatacatat cgtaagattg
     2401 gttggcgtta tcgggaatga tatcgttcaa tacatcatcc agacgatcga tcgggtcttt
     2461 gcactcaact aacggagttt cttccaagtt gttctgtggt aagaaactga gcaatttacg
     2521 gatcaattgc aaaccatcct cttctgtatc gacagcgaaa tgggctacac ccgatttcgt
     2581 ggtgtgtacg ctggctccac ccaactgctc ttgggttaca tcctcacctg ttacggtttt
     2641 tactactttc ggacctgtca agaacatgta gctggtacca cgtgtcatga tgttgaagtc
     2701 tgtcaaagcc ggagaataaa cggctccacc ggcgcaaggg ccgaagatac cggaaatctg
     2761 gggaacaaca ccagatgcca agatgttacg ttggaaaatc tctgcgtatc ctgccaaggc
     2821 gtttacacct tcttggatac gagctccacc ggagtcgttc aaaccgataa cgggagcgcc
     2881 catcttcatg gcttgatcca ttactttaca gatcttcata gccaaagcct cagacaaggc
     2941 tccaccgaat acggtgaaat cttgagcgaa gatatatacc aaacgtccgt cgatcgtacc
     3001 ataacctgtt acgataccat cgcctaaata tttagttttc tcgataccga agtttgtaca
     3061 acggtgttga acaaacatgt cgaattcctc gaaactacct tcgtcaagca acatggcgat
     3121 acgctcacga gcggtatatt tgcctttttt gtgctgtgat tcgattcttt tctctcctcc
     3181 acccaaacga gcttgctcac gaagtgcgat gagctctttt actttttcaa gctggttact
     3241 cattgtattt tgatttgttg ttagaaatga acggattaat tatttgttgc ccggcatgca
     3301 aagttctgtc aatacgctgc aagttgattt cgggtgaagg aaagcgatgt tcaagccttc
     3361 cgcgccacca cggggagctt tatcgattaa tttaacgcct ttttcctcag cctcgttcaa
     3421 agctgcctgt acatcaggta ccgcaaatgc gatatggtgg ataccttcac cttttttctc
     3481 gataaatttc gcaatcgtgc tatcttcgct ggtcggctct agtaattcaa tcttagtctg
     3541 tcctaccttg aaaaatgcgg tttttacttt ttggtctgct actacttcga tattgtagca
     3601 ttttaatcca agaacgcctt cataataggg taaacaagcc tcgatactct tcactgcgat
     3661 acctaaatgt tcgatatgtg taagttccat gtcaataata atttaaagat ttagtaaatg
     3721 tttgtttcta ttgtgtgcaa atgtacacta ctttttatga atgaggaaat aattttttgt
     3781 ttttatctcc cagtaaatgt gtttaaagat acattttatt aaaaatcgac aatcagacga
     3841 acgttcaatt gacgtccggt cagatagttt ggaactgcgt attggacatt atatacatct
     3901 gttatccaat agtaggaact aacatttttg atgtctaata tgttaaacac atccagacct
     3961 agccaaatgt ttttcaaatg gcggaagaag cccctgtcca tgatagcgtc cgtgcctcct
     4021 gccaattgat aggagaggcc gatatccaca cgtttgtagg cgggcgtacg gaaatagccg
     4081 gcttcgtatc ctttgcccgg gattgtctgg ggaagtcctc cggatagaac tcctttcaga
     4141 tttagcttga ctcgtttata gcccgggaaa taatcttgaa agaagagtga gatgttgtag
     4201 ccttggctat tggccatagg aacggtcgtt gtttcccgga tggtttgctg ggctttcatc
     4261 aaggagaagc tgatccatga gtcggtaccc ggtacgaatt ctccgaagaa tttgacatcg
     4321 agtcccatga cgtaaccttt ggcgcagttc tcgccgtaat agcggatctt gacgttatct
     4381 acggtgtagg gattcagatt gtccagcttt ttatagtaca tctcggcggt caccttgaaa
     4441 ttccggtcta cggcacggaa cgtataatct cctcccaata tgaaatggat ggagcgttgt
     4501 gactttagat ctttgttcaa taccgtgata ttattgccgt tcttatcttt gtctactcta
     4561 cgtaattcct tgtagaaggg cgattgataa tacagtccgg tggcgaaacg gagcgtcaag
     4621 tcttggtcga agttcgggat aaagcccaat gaggcacggg gactgaaaag gaactcctta
     4681 ttataagtcc aataactacc tctaacccct gcgactaacg tgaacagacc ttgcttggtc
     4741 ctgaatttga acgcgtcttg cgcataagcg gaaaagcgtg tgctttctat ctgattatca
     4801 gaaaagaggt tcgaatatac acttacgtta ttaccggttt ggggcaaaga ataacctgag
     4861 gaatcccttt tttcccattc actgatctta tcattgattt tctccatttg taccgtggct
     4921 ccccatttca acgtattgtt taaaaggcgg gccatcccat aatgcccgac attcatgacg
     4981 gtggagttca aacggtttcg tgcgtgctcg tgataacggc ctacggacat ggcggctgac
     5041 gcgtcgtcat ccggattttc cgctccgttc tcgctcagcc aatattctcc ggcgatatcg
     5101 tatccctctt cttccttgct tttgaaagcg gaggcttgaa gtcccaactc tgtgttctca
     5161 ttggggttgt gtttcaatgt aagcgcaccg aataaggttt ggaaacggtc tctttccctt
     5221 ccgtcgaaat agactttgaa gttcttggga tgctcggctg taccgaaaga ggtttcccgg
     5281 ctataagggg tgaatttata attattgtta gcgaggtttc ccaagaaatt gatttcccat
     5341 ttaggggcca attggtacgt gatgtaagtt tgcagatcga taaatttagg gtcgtattca
     5401 gcgtctgtat ccatggtacc caagatagac cgaccgcttt taaagcggaa acccgttact
     5461 tgggtaaatt taccgataga actgcctaca taagcatttg cgcccaacaa gctcgcagaa
     5521 gccgagcctt cgaacatctt aggcttttta taggtaatat ccagcacgga actcatcttg
     5581 tctccgtaac gagcctcgaa gccaccggcg gcgaaattga ccgcctccgt caggtccgga
     5641 ttgataaagc taaggccctc ttgttgtccc gagcgaatca gaagcggacg gaatacctcg
     5701 atcccattca cataaacgat attttcatca taactacctc cacgtacgga gtactgggaa
     5761 cttaactcgt tattggacga tactccggca aacgtaacga ccaagctctc tatactacct
     5821 ccggagggat cgggcaataa cttaattttg tccgcattta gggactccat ggtcgtggtc
     5881 tgcttgcgga tggcagtaac ggatacttcc cctaaatcaa atgaggtatt gttcatctgt
     5941 acgttcaggc gcatatcggc ttgtgccgaa ggaatgatac gttcagcttt attatatccc
     6001 agacaagagt aaataacgga gatagaatcc cccggcgata tggaaaagga ataatatccc
     6061 ttctcgttgg tcatggagcc gatcaacgtg ttcttaaccc ggacattcac taattccaga
     6121 gggttaccgt cggcgtcacg gacataacca gtgattttta tgcggccttc gccaaaggca
     6181 ctcacggaaa taagtataaa tagcagcgcg gctatcgcac gaatcttcat aatctattgt
     6241 tcaattataa aaatactaac gagaaaaaag aacgatacgt atatatgggt gcaaaaaatt
     6301 atatttatat ttgcgaatct taatattaaa agagtacaaa gaacgaaaaa aatggagagt
     6361 tttgcaacac ttatacaaaa tagaagaagt acacgtaagt ttaccgaaca actactttca
     6421 cccgagcagg tagaactgat cttgaaagcg gcgttgatgg ctccggcctc aaaacgtagt
     6481 aatccttggc agttcgtggt cgtggaagat aaggaaatgt tgaagaaact tgccgggtgt
     6541 aagaaaaatg gttccgcttt tctggagggt tgtgccttgg ccgtggttgt cttggcgaat
     6601 gtgatggaaa gcgatgtttg gatcgaggac gcttcggtcg cttctattta tatgcaattg
     6661 caggcggagg atttgggatt gggcagttgc tggtgtcaga tccggaaccg ggtaacagag
     6721 gacgaggcgg attcgaataa ttatgttcgt tcgttgctgg atatccctta tcaattggat
     6781 gtcttgtcta tcattggtat cggttataag gatcaggttc gtaagccttt tgatgaatcc
     6841 catttacaat gggagaagat acatatagga aagttctctc ttccggaaga aaataaagag
     6901 gcggaagaat gagagtcgta tttgttggtg ctggaaactt agctacccgg ctttcgttgg
     6961 aaatgcgtaa gtccggaatg agtatcgggc aagtgtatag tcacacaagt gagcatgcta
     7021 agattttagc cgatgaattg ggatgtgggt ggactgttgt cccggaagat attgtggaag
     7081 atgccgactt gtatgttttc tctttgaaag atgccgtgct ccaagatgtt atcgcccgtg
     7141 taaaaccgaa taacggtttg tgggtgcata cggcagggag tatgccaatc tctgtatttg
     7201 aaggtcttac ggctagatat ggggtggttt atgcgttaca aacgtttagt aagagtaggg
     7261 aggtggattt caagaaaata ccgttctttt tagaggcgaa ctcgtctgaa gatgagaagg
     7321 tgctgggaga ggtggctagg gcgctctcca gtgatgtccg tttcctctcc tccgagaagc
     7381 gaaagaactt acatttagcg gcggttttcg cttgtaattt tacgaatcat atgtatgcgc
     7441 tagctgaaaa gatcttggaa gaacagcaaa taccgggaga ggtcttgcta cctttgatag
     7501 acgagacagc cgctaaggta catgtaatgt cgccggcgcg agcccaaacg ggaccagcta
     7561 tacgatatga cgagaatgtg ataaacaaac atatggctat gcttaaagat ccggatatgc
     7621 gaaatctata tgagctgatt agccgaagta tacataagga ggctcgacat gagtagtata
     7681 aactatgatt tgagaaaaat aaaggctttt gtctttgatg tagacggggt gctatcctgc
     7741 gatgtgattc cgcttcaccc gaatggcgat ccgatgcgta cggtcaatat caaggatggc
     7801 tatgccttgc aattggccgt gaagaaaggt tatgaggtcg ctataattac gggcggatat
     7861 acggaagccg tacagattcg cttttctcgt ttaggaatac aacatattta tatgcgtagc
     7921 gctgtaaagg tgcatgactt taaggatttt atggaaaaaa cgggcttgtc tcctgagcaa
     7981 atcatgtatg cgggtgatga tattcctgat tatgaggtaa tgacgcgagt cggattgccg
     8041 gtggcacctg cggatgcggc tccggagatc aaggagatag cgaaatatat atcctcccgg
     8101 cgaggtggcg aaggcgtagc tagggacgtg atcgagcaaa cgatgcgggc gcaaggacac
     8161 tggttcggcg aggaggcttt tgggtggtaa aattttggtg aatgtgtaac gcttaatcga
     8221 ataggttatg ttagagaatt taaaaaagta caagatcgtc ttagcctcta attctccgag
     8281 acgacggaat ttgttatctg gtctggatat cgacttcgag gtgaggataa ttccggatat
     8341 tgacgagtct tacccggatt ctattgactc catggagatc cctttatata ttgcccgttc
     8401 gaaagcggag gcctataaat cgactatggc ggatgatgaa ttgctaatca cggcagatac
     8461 gatcgtttgg acgtttgacg gggttatggg gaagcctgcg aaccgggagg aagcttatgc
     8521 tatgcttcat gctttgtcgg atcatgtaca tcaggtaata accggcgttt gtatcatgac
     8581 gaaggacaaa aatgtaggct tttccgtcga atctgcggtt tgtttcgcaa aattgggtga
     8641 tgaagagatt aattattatt tggataaata taaaccttat gataaagcgg gagggtatgg
     8701 cattcaggag tggatcggtt atatcggggt agaggctatc aatggtagct tttataacgt
     8761 gatgggatta cctgtgcaaa agctttatca ggaattgaaa catttttaat ctcaattcaa
     8821 ggtaaagtat ttatccttca tataatattc tatctgattt aatgtgtgcg ctaaggctgg
     8881 gggaatcggt aagacgaccg gtttctccac attccattcc gggtcattta tgatcatgtc
     8941 ggataggctg cccgcatgta ttaagataag gcgggtaggg gctgaggcta taaccttatg
     9001 attggtgttt tgcgcaagta gcatgaaatg atcttttgcc acttccgcta tatgtgtccc
     9061 ttcttggctg taaataataa gttttcccga aaatacgaag attaatagat tatccgtggt
     9121 tgtggtatta aacagggaat ctccggctct cagtattttg cattcaagtt gatttagata
     9181 acgcttcatg taggaactta aggattttcg aggatagcca atgtttttct gttaggaagg
     9241 tattccaaca taccttttga gtaggtgact ttctgttgtc cgttgttgtc cgcataaata
     9301 ataaaatact ctatttgggg gatggattgt gccagtagct tcgctttctc gactcccaaa
     9361 accatgaaag tcgtagcgta agcgtctgct gtcatacaat cttccgccac gatggtcgcg
     9421 ctaagaatat tttgtccagc gggataaccg gtcgccggat tgatcgtatg ggcatatttc
     9481 ttaccatcct tgatgtagaa gtttcggtag tcaccagaag tagccacacc ccctttttgg
     9541 cataattgta cgatctcttc aacatcattt gttacgccac ttgtccctat ttccggcttg
     9601 ttgatgccga ctcgccaaca gtcaccttgt tgatttacgc ctttcatggt gacctcacca
     9661 cctatttcta ccatgtagtt ctttacgcct tccttttcca gcaggcgggc gatgacatcg
     9721 caagcataac cttttgcgat ggacgaacaa ttcaatagaa tccggggatc ttctttgatg
     9781 attttctttc cttccaatct cactttttga taaccgacga aagcctttat gctatcgatc
     9841 atctgcgggg ttacgctatc catcttactg aatccgaatc cccatagatt aattaatgga
     9901 gcacaagtaa tatcaaaagc tcctcctgat ttttgggaga tttcttccgc cttattgaat
     9961 acttcggtaa accattcgtc tacctccaca tcctcgttat tattgacttt cgcgatcgtg
    10021 gagttggggt tgaaaggatt taaggagagg ttaaaacgtt gcagctcgct gtcgatctta
    10081 tcggttagga tttgcttggc cttgtatttg atgtggtaac ttgtatgaaa aacagaacca
    10141 ctctcttcga aatattggcc cttgtccgag caagccgtat gcgataagat caacaggctg
    10201 actaatatgg taatattctt gcgcatcatt atgaaatttt atgtcgcgaa cttacataaa
    10261 aaattccata tatgcccctt tcatggggga gacgctattg tgtgtataaa tatcaaggat
    10321 tcctttttta tattgtgact ctggttttat ccaatgtgca cgcctttcgg ataggatctt
    10381 ttctatctct tccacgcttc tctcaatact gtcggtaccg attatatcca atgttctcgc
    10441 tggaatatcg atacggatca agtcatcgtt ttcaaccaag gcgattggtc ccccctcgga
    10501 agcctccggg gatacatgtc cgatcgccgg gcctcgggtc gctccggaga aacgaccgtc
    10561 ggtgatcaat gcgatggtct ctaccaactc aggatcggag gcgatcgctt ctgtcgtata
    10621 aaacatttct ggcattccac ttcctttcgg tccttcataa cggataaata ccgcttctcc
    10681 cggatggatt ttcttttgta ataccgcctc aatagcgttc tcctcacaat cgaataccct
    10741 cgctttcagg gtgacttgca tcaagcgggg tgaaatcgcc gaatgtttta cgactgcccc
    10801 ttcgggcgct aaatttcctt tcaatatagc gatggctcct tgtgccttga tcggtgtatg
    10861 aaaaggtttg ataatatcgc caacctttac tcctagggca ggaagatatt tatggcaatt
    10921 ctcatagaag ccgttgagtt gtaaatcttt taagttttct tccaatgttt tgccggtaac
    10981 agtcatgacg tcgagatgga ggaattcttt gatttcttcc atgatcgccg gtacgcctcc
    11041 cgcataccag aaatattcgc cgggccaaaa accgctggga cgtatattta aaaggtaggg
    11101 gatcttacga tgtatcttgt cgaacaaatc cggtgataac tggattccca gttcatgggc
    11161 gatagctgga agatgaagca ggctgttgct ggaacccgct atggcggcat gtaccatgat
    11221 cgcattttca aacgcttgta tcgtcatgat atcggagggt tttaactctt ctttcgccag
    11281 tccgagtgca tgttctccgg ctttacgggc ggtttctttt aactcgggta aatgggcggg
    11341 gatcaaggcg gagcccggta aagcgatgcc aagcgcttct gccattactt gcattgtaga
    11401 ggcggtaccc atgaaagagc aagctccaca atccggacat gcgtcacgct tataaaccat
    11461 gaattgttct tccgttattt cttttcgctc gtactgggcg ctataggtac cgatttgttc
    11521 taacgtgagt aggttgggac cggctttcat tataccacca ggcatgaata tagcaggcat
    11581 atctagccgg gctatcgcca tcaaatgcgc agggacggat ttgtcgcaac tggctataaa
    11641 gacaccagcg tcgaaaggag tcgcttttac atgaatctcc atcatggcgg ccatgatatc
    11701 acgggagact aatgagtagt tcataccatc gtgtccctgc gcctctccat cacaaatatc
    11761 agtgacgaag tagtttgcgg cacgtccccc cttttccttt ataccgattc cggcctcgtc
    11821 caccaattta tccagatggg cgcttcccgg atggctatgt ccgtaactgc tttctacaat
    11881 gatttgcggt ttactcaatt cgtcgatttt ccaaccgctg cctagccgga gtgaatccag
    11941 ctccggcgct agttttcgta attgctggct tttcatgtct attaattaat gtataaggtt
    12001 atttattcaa taaggtatcc ctagctaaag aatacatgct ctatcaaaat ctttgtaccg
    12061 ataccgatta agattaaacc tccgatgagg tccagcttca agtcgattct cttgccgaat
    12121 cggttaccga aatagacgcc gaaggcagag atagcgaagg tgacaacacc gatagtcgag
    12181 gcttgcagca agagcggtga ttttaagatc gccagagaga ttcctacggc gagggcatcg
    12241 atacttgtcg ctattcccaa tccgcataat gtccggttac atagaggatc gaatttcccg
    12301 tcttcctcct cttccttcgc gctatcgtat atcatttttc cacctaagta aagcaagagg
    12361 gtaaatgcga tccaatgatc gaaggcgcaa atgtattttt cgaatcctaa tcccatcgta
    12421 taaccaatca cggtcattcc ggcttggaat ataccgagca cgctcgctat cttaataata
    12481 ttaccggcgg tgcagttgtt cttaagaact gcgccgccgg taactgatac tgctaggcta
    12541 tccatggata agccgatcgc tagtagcaga acttcaatgt ataacatact agaatgattc
    12601 ccgtttaata atttcttcta tgggcttacg tttctttgga gtctcatcga ataatgccgg
    12661 gtcggaagga tagccgaacg gtatcagtac aacaggctcg atcgtttccg gaattttaaa
    12721 atgtttacgg caaagctccg tgtcgaaatt gcaaacccaa caagtaccca atccttgttc
    12781 ggcagcggct aaacaaatgt gttccgtggc gatagccgta tcgatatcca tatgatcctt
    12841 atgatcgccc cgtttccaag attgctgatg atctccgcaa acgatcaagt aataaggcgc
    12901 ttgcttgaac cattcccggg gatagcattc ttgtaattta gcttttcctt ccgcactttg
    12961 aacccataca aaataccaag gttgataatt taccgccgaa ggggccaaac gagctgcttc
    13021 taggatataa tcaatctttt cttgctctac gtttttgggg gcatactttc ggatagagca
    13081 acgttttctc gctaattcta ggaaactcat atctcatcct ctattttata gttattgcga
    13141 ttcggagaat tgcgggaaat caactccccg ataaagcccg ctaggaacat ctgggttccc
    13201 agaatcatcg ctgtcaatga aatatagaaa taaggggaac ttgtaaccaa aggtcttaga
    13261 tctccagagt acatcgagat caatttcatg ctgagtacga ttactagagc gataaaacca
    13321 atgaagaaca tagcgcttcc ccataaaccg aagaagtgca tcggtttctt tccgaatttg
    13381 gaagtaaacc aaagcgtgat caaatcaaga taaccgttca cgaagcgatc caacccgaat
    13441 ttagtagttc cgtacttgcg ggcttgatgt ttcactactt tctcgccaat cttgtgaaat
    13501 ccggcaatct tagctaaata aggtatgtaa cggtgcatat cgttatacac ctctatattt
    13561 ttaatgacaa cattcttata cgctttcaat ccgcaattga aatcgtgtaa gttctttatt
    13621 cccgagaatt tacgagctgt tgcgttgaat aatttcgtgg ggatcgtctt agacaacggg
    13681 tcatatcttt
//
