LOCUS       gnlProkkaEGHMHIGH_27    7022 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EGHMHIGH_27.
ACCESSION   gnlProkkaEGHMHIGH_27
VERSION     gnlProkkaEGHMHIGH_27
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 11:37:13
            Original ID  :: gnl|Prokka|EGHMHIGH_27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7022
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7022
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3463:7021]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3464..7021
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..7022
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7022
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(323..478)
                     /locus_tag="ctg27_1"
                     /transl_table=11
                     /translation="MAIFGDCLGENAPINSLKLRKITHSLTLSNEKAMRELGWKPMNVL
                     ENFQIE"
     CDS             complement(436..711)
                     /locus_tag="ctg27_2"
                     /transl_table=11
                     /translation="MIHGIRNGKYLSIAGGEARKSVLMVQDITNLVPLLIEKGGIYNVC
                     DSYQLSFRELEMVICKQLNKKRPISIPYCLLKVWPFLVIVLGKMPQ"
     CDS             1497..2060
                     /locus_tag="ctg27_3"
                     /transl_table=11
                     /translation="MAQLESKQLNKIGLHENATNRNMDEKLLLKCENSIRAYKIVNLLN
                     KHNIALRQHDESQDPRVGAYGAVTGIAIYVFAKDYEKALSIVSPILKDFNTISTFCPKC
                     GSENVKPITGNHKYITYLIFLCLFLILTPGIYIALPEDFGLRSSLINKIALMMVVLGFI
                     LMPIINHYNVNYKCKKCGNRFRHY"
     CDS             2398..3471
                     /NRPS_PKS="Domain: PKS_ER (37-232). E-value: 7.6e-21.
                     Score: 66.4. Matches aSDomain:
                     nrpspksdomains_ctg27_4_PKS_ER.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 105.6; E-value: 4.9e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_4"
                     /sec_met_domain="ADH_N (E-value: 4.4e-09, bitscore: 25.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNIIVCDSNINKKDIEGYKVVIDGYEYLFALLDIPVNKYTDKIS
                     DQSVVVRVSAFSCNYRDKGILYNFLKKCKDYNLKESYYYSFLGSEFVGKVIKIGRNVRS
                     FKIGDRVMSDNSYPFKVDGKIGGIVSNYASKRIQIFHESCLIKVPDSMSDIEAAAFSLT
                     ASTAHSMVSKSKLKEGDKVLVTSLFSNTSLGCLELLKNISGIKIYGLTTGYKEAQSLSE
                     KFKIQKIFTPDDFYTATNKMNINFNVIIDPFPDIHINYLHSYLNYSSRYISCGMSSHQN
                     EKIDFHKILYSLIVSNSQFIGNCLGLPYDLKAVINEYSHERYKVYVDSVYTGRQISDFI
                     NKSFNERHFGKVVYSYE"
     aSDomain        2509..3093
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg27_4_PKS_ER.1"
                     /evalue="7.60E-21"
                     /label="ctg27_4_PKS_ER.1"
                     /locus_tag="ctg27_4"
                     /protein_end="232"
                     /protein_start="37"
                     /score="66.4"
                     /tool="antismash"
                     /translation="NKYTDKISDQSVVVRVSAFSCNYRDKGILYNFLKKCKDYNLKESY
                     YYSFLGSEFVGKVIKIGRNVRSFKIGDRVMSDNSYPFKVDGKIGGIVSNYASKRIQIFH
                     ESCLIKVPDSMSDIEAAAFSLTASTAHSMVSKSKLKEGDKVLVTSLFSNTSLGCLELLK
                     NISGIKIYGLTTGYKEAQSLSEKFKIQKIFTP"
     CDS             3464..4687
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     198.9; E-value: 2e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_5"
                     /sec_met_domain="LANC_like (E-value: 3.5e-41, bitscore:
                     129.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLNINVCKVMKRKTLIEEDKKKIEISNKIDEIYLIMKENVHCN
                     NWGVLDGFSSTILFLSRLYIYSKDDKILDDLYNRINLLISYLDKIKLPTICGGYAGICW
                     LFRYLYKEKLVESNNINEVLDGLEKYITKTFYNYYINDTDFLHGGLGIAFYFLLSDTNY
                     SENLCKVYLDRLDKNKQNQKDGSCMWTTQVYNGGENEAVANLSLSHGMASIIIFLAYYH
                     SKTNNPKAKRLLQQAIEFYKRNTNPNNFYSMYSNWIKINSPSNLSESRLAWCYGDLGIA
                     KALNYAGVSLGNSDITNFSFEVLNKTIPRFMNSHVEDASFCHGSSGISHIYNHFYQITG
                     YDAYKNSAIFWLNDTLNRIKYLEVNSSFSTELNDVCSILTGLSGVGLSLLSSIEDKEDN
                     WNELLLLL"
     CDS             4665..6860
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     400; E-value: 3.2e-121)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_6"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.7e-124,
                     bitscore: 405.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.8e-11,
                     bitscore: 31.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYYYYCNLNLYKMNKYIPYNQCIIRTPLFPINYIDKIEDFELSI
                     FQQSFKEAVYIATPVLYQELYIKNNINERTINSAIKYYVRSCTRCTPYGIFAGCDIVPI
                     RIDDNYSNIIMSDLKNYKTYTRIDMNYLCELIRKLDLMPQIQNAITYHVNTTSYFLGKN
                     LRYIEYRINKSKRNYTFSEISHTPYLNNIIKALKKTPLTKKEIIRLLIKNKEIEEEEAL
                     NFVQTLIDEQILISNLEPSVVGEDLIQQLHHNLSEINYNLEFINSLIYLLKECDKESLG
                     NKESIINNIYRLLSDGMLFEQDTLMQVDTLNKVKQGIIGNNITKVIDKCIYFFSKFQPS
                     HKSETFELFKRRFYEKYEEQEVPLVVALDPQVGIGYGNWTENNGDINPLLQGLPNPFLD
                     RSYKIDMDLTPVTMLLIKKYEEAIKQGLHEIEILDEDLNEFEERDLKLPQCSVMLSVLS
                     NDDTPSILLKGIIGGATSRLISRFEYLDSKIENFVNEINKRDELYYKDCIVAEVMHLPE
                     DRIGNIQMHPNNRQYGICYLSSPTTKYVKKIIPIDDITISVYHGQEVILKSKKNKKRII
                     PMLSTAHNTKNGLPIYSFLSDYINQESMSYSFDWGSYFHNKSFLPRVIYSNVILKPARW
                     LIHPNEFPQNKNLNSDELYSWKLKQRIPDEILITLGDNQLYINFNKEHLVKIFISELKK
                     KRPIILEEFLYSSKNINLVESQEGFFANELIINLYKK"
     CDS             6857..7021
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_7"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.7e-10, bitscore:
                     28.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQRIFIIGGEWIYFKIYSGPKTIENIFINDIMCKINLLIKQRMI
                     DSFFFVRYMD"
ORIGIN
        1 agccagtata aaccaagggt attcaaactg attcgtcagg aaaaaagtca atgcacccaa
       61 atagaagatg attcctccac ctctcagagt aatccgagtg tgtgaactcc gctcgtttgg
      121 cttatcgata atattgcatt tatcagcaat acggaaataa aaaagttctg ccaggaatag
      181 cagaactaag attagcagat aacacataaa ctattcgttc tttttaatga aataaaacca
      241 aagttgaagt cctaaaaagg caaaagaaat accccctatt aggagtccta taatccccca
      301 aaaatccact cacaatacct ccttattcta tctgaaaatt ctccaaaaca ttcataggtt
      361 tccacccaag ttcacgcata gccttttcat tactaagagt caaagagtgc gtgatcttac
      421 gaagttttaa actgtttatt ggggcatttt ccccaagaca atcaccaaaa atggccatac
      481 ttttagcaaa caataaggaa tagatattgg tcttttttta ttcaattgct tacatatcac
      541 catctctaat tcacgaaaac tcagctggta actgtcacaa acattatata tccctccctt
      601 ttcaatcaat agaggaacaa gattagttat atcctgaacc atcaaaacac ttttccgagc
      661 ttctccccca gcaatactta agtacttacc atttctaatc ccatgaatca tcgctcctaa
      721 atttcccgga ggattaggtc cggcaattta ggctactatt gacggaacga tagattcaga
      781 cgcaatgctg aataattact tatacgactt cttgtcgcac gagataccta aagagacaaa
      841 aaatcaaatg attttcaaca atttgattat gagtaaattg taaaatttta taatattttc
      901 tcataactac ggtgttgcat tgatactgtt acactattgg taagtgatgt acttcctagt
      961 aaggctacac cattggatta attcttttat ttgctcagaa agagcgagaa aaatcttcag
     1021 cttaatctaa taaatgattc ctgtttgctg cagaaaaaat ttcttcctag taaagatgga
     1081 actcgaagag gtgtaataca aaagaaaaaa atacaagaag cataaaaaga aagaaaagcc
     1141 tattctcaaa cttattgatc cgcctttcct gttggtagag gagattcatc ttagcatgaa
     1201 aaagacaata gataaaaaac ggtattcaga aagatcgttt tgctaaaatc agaacgagta
     1261 ttagttcttg cctacaactt taaattttat ttacagaata atatatttta aaacaaaatc
     1321 taagtaataa ttggaatatg aactataaaa atcaatattc tttttgtaac ctgatttttt
     1381 cgtaagatag acaaaagtgt taaattacgc aaaatacatc agcatatatt tataatcaaa
     1441 tttattttga ctatattaga aaaatgttcc ttcaatcttt aaatataata tgaacaatgg
     1501 cacagttaga atctaaacaa ttaaacaaaa ttggtttaca tgagaatgct accaatagaa
     1561 acatggatga aaaattatta ttaaagtgcg aaaatagtat tcgcgcttac aaaattgtga
     1621 atttgctcaa caagcataat attgcattac gacagcatga cgagagtcag gatcctaggg
     1681 ttggtgcata tggcgccgta actggtattg ctatatatgt atttgctaag gattatgaaa
     1741 aggctttatc tatagtttcc cctattctta aagattttaa taccatcagt acattctgtc
     1801 caaaatgtgg aagtgaaaat gtaaaaccca ttactggtaa tcacaaatat attacttatt
     1861 taattttcct ttgcctgttc cttatactta ctcctggtat ttatattgct ttgcctgaag
     1921 attttggact caggtcttcc ctaataaata aaatagcttt aatgatggtt gtgctaggtt
     1981 ttattttaat gccaattatt aaccattata atgttaatta taagtgtaaa aaatgcggca
     2041 atagatttag gcattattag ctttattgtt cataatcgat tctattgttt tattacaaca
     2101 gaatcaagtt aataaaaaga gattgtccta tataataaat gtttttatta tgaggtttaa
     2161 aattccgact tatgtataca tcactatcta tttgaaataa atggaatgag gatctttcag
     2221 ttatatattc tataagtatt ctatccatta ggaatcatta cttaaaaata aaaatatact
     2281 taagtttgac tcgtttttat ccaaaagtat aatagatagg atatatttct atttttatag
     2341 aactccaaga atgctgattt aattgagaaa atgtaaattg ataaataaat aaaaaacatg
     2401 aaaaatataa tagtctgtga ttccaatata aataaaaaag atattgaagg ttataaagta
     2461 gtaattgatg gttacgagta tttatttgct ttgcttgata ttccggtaaa taaatacacc
     2521 gacaaaatta gtgatcagtc tgtagttgtt agagttagtg ctttttcatg taattacaga
     2581 gataaaggaa tattgtacaa ctttttaaaa aaatgcaaag attacaattt aaaagaatca
     2641 tattattatt catttctggg atctgaattt gtgggtaaag tcataaaaat aggtaggaat
     2701 gtgcggtctt ttaaaattgg tgatagagtt atgtccgata atagttatcc ttttaaggtt
     2761 gatggcaaga ttggtgggat tgtcagcaat tacgcatcaa aacgtataca aatatttcat
     2821 gaatcatgtc taataaaagt tcctgactct atgtctgata tagaagcagc tgctttttca
     2881 ctgactgctt ctaccgctca ttctatggtg tctaagtcaa aattaaaaga aggggataag
     2941 gttctagtga catcattgtt ctccaataca tccttaggat gtttggaatt actcaaaaat
     3001 ataagtggga taaaaatata tggattaaca actggatata aagaagctca atcattatcg
     3061 gaaaaattta aaattcaaaa gatattcaca ccagatgact tttatactgc aacaaataaa
     3121 atgaatatca attttaatgt gataatagat ccatttcctg acatacatat aaattatctt
     3181 cattcatatt taaattattc ttcacgatac atatcatgtg gaatgagttc tcaccaaaat
     3241 gagaagatag attttcataa aattttgtat agcctgatag tatccaattc ccaatttata
     3301 gggaattgcc taggattacc atatgatctt aaagctgtaa ttaatgagta cagtcatgaa
     3361 cggtataaag tgtatgtgga ctctgtatac actggaagac aaatttctga ttttataaat
     3421 aaatccttta acgaaagaca ttttggaaaa gttgtatatt cttatgaata gtcttaacat
     3481 taatgtatgt aaagttatga aaagaaaaac attaattgaa gaagataaga aaaaaataga
     3541 aatatctaat aaaatagatg aaatatacct tattatgaaa gaaaatgttc attgtaataa
     3601 ttggggagtt ttagatggct tttcgagtac tattttattt ctgtcacgct tatacatcta
     3661 ttcaaaagat gataagatat tggatgattt atacaataga attaatttat taatatctta
     3721 tttggataag ataaaacttc ctactatatg tggagggtat gctggaatat gttggctatt
     3781 cagatacctt tataaagaaa aattagttga aagcaataat attaatgagg tcttagatgg
     3841 actagagaaa tacataacga aaacatttta caattactac ataaatgata cagatttttt
     3901 acatggagga ttaggtattg cattttattt tttactttct gatacaaatt atagcgaaaa
     3961 cctttgtaaa gtgtatttgg atagacttga taaaaacaaa caaaatcaaa aagatggaag
     4021 ttgtatgtgg acaacacaag tttacaatgg aggagagaat gaagctgttg caaatcttag
     4081 cttatctcat ggaatggctt caataattat atttcttgca tattatcata gcaaaacaaa
     4141 caatcccaaa gccaagagat tattacagca agcaatagaa ttttacaaaa gaaacactaa
     4201 tcccaataat ttttattcca tgtatagtaa ttggattaaa ataaactcac ctagtaacct
     4261 ttcggagtct aggttagctt ggtgttacgg tgatcttggc attgcaaaag cattaaatta
     4321 tgcaggagta tcattgggta atagcgatat tactaatttt tcttttgaag ttttaaataa
     4381 aacaataccg aggttcatga atagccacgt tgaagatgca tctttttgtc atggttctag
     4441 tggaatttct catatatata atcattttta ccagataaca ggttatgacg catataaaaa
     4501 ttctgcaata ttttggctga atgatactct taatagaatt aaatatttag aggttaactc
     4561 ctcatttagt accgaactta atgatgtttg ttctattcta acaggattgt ctggtgttgg
     4621 tttgtcctta ctatcttcaa tagaagataa ggaagataat tggaatgaat tattattatt
     4681 attgtaattt aaatttatat aaaatgaata aatatattcc ttataatcaa tgcattatta
     4741 gaacaccgtt atttcctatt aattacattg ataaaataga agactttgag ttatcaatat
     4801 ttcagcaatc atttaaagaa gcagtttata ttgcaactcc tgttctctac caagaattat
     4861 atataaaaaa taatataaat gaaaggacta taaattccgc tataaaatat tatgtccgta
     4921 gttgtacaag atgtacacca tacggtattt ttgcgggttg tgatatagta cctattagaa
     4981 ttgatgataa ttattctaac ataattatgt cagaccttaa aaattataag acatatacac
     5041 gtatagatat gaactattta tgtgaactta taagaaagtt agatttaatg ccacagatac
     5101 agaatgcaat tacatatcat gtaaatacaa cttcgtattt tttaggtaaa aatttgcgct
     5161 atattgagta tcgcatcaat aaatctaaac ggaattatac cttctctgaa atttctcata
     5221 caccatattt aaacaatata ataaaagcat taaagaagac ccctttaaca aaaaaggaaa
     5281 taattaggct attgataaaa aataaagaaa tagaagagga agaagcttta aattttgttc
     5341 agacacttat tgatgaacaa atcttaatta gtaatttgga gccatctgtg gttggcgaag
     5401 atttgattca acaattgcat cataatcttt cagaaattaa ttataatcta gaattcatta
     5461 attctctcat atatttatta aaagaatgtg acaaggaatc actaggaaat aaagaatcga
     5521 ttattaataa tatataccgt ttattatcgg atggtatgtt atttgagcaa gatactctaa
     5581 tgcaagtaga tactttaaat aaagttaaac aaggcataat aggaaataac attactaaag
     5641 ttattgataa atgcatatac ttcttttcaa aatttcagcc aagccataaa tctgagactt
     5701 ttgagctttt taagaggaga ttttatgaaa agtatgaaga gcaggaagta ccactagttg
     5761 tagcattaga cccacaagta ggaattggtt atggaaactg gactgagaac aatggcgata
     5821 taaatccttt attacaaggg ttgcccaatc cttttttaga ccgatcttat aagatcgata
     5881 tggatctgac tccagtcacg atgttgctaa taaaaaagta tgaagaggct ataaaacaag
     5941 gattgcatga gattgaaata ctagatgaag atttaaatga attcgaagaa cgtgacttaa
     6001 aacttcctca gtgttcagtc atgctctctg ttttatcaaa tgatgatacg ccatctattt
     6061 tattaaaagg gataattggg ggtgctactt ctagattgat ttcaagattt gaatatttag
     6121 attctaaaat tgaaaatttt gtaaatgaaa taaataaacg tgatgaatta tattataaag
     6181 attgcatagt cgctgaggta atgcatcttc cagaggatag aattggaaat attcaaatgc
     6241 atcctaataa tagacaatat ggaatttgct atttatctag tccaaccact aagtatgtaa
     6301 agaagatcat accaattgat gatataacca tttcagtgta ccatggacaa gaagttatat
     6361 tgaaatcaaa aaagaataag aaaagaatta ttccaatgtt atcaactgca cataatacaa
     6421 aaaatgggct tccaatatat agctttttat cagattatat aaatcaagaa tccatgtctt
     6481 actcttttga ttggggatca tattttcata ataaatcatt tctcccaaga gttatctatt
     6541 ctaatgtaat actaaaacca gctagatggt taattcatcc caatgaattt ccacaaaata
     6601 aaaatttaaa tagcgatgaa ttgtattctt ggaaactaaa acagagaata ccagacgaaa
     6661 tattaataac tttgggggac aatcaattat atataaattt caacaaagaa catcttgtta
     6721 aaatttttat tagtgagctc aagaaaaaga gaccaattat tttagaagaa tttctatata
     6781 gttctaaaaa tataaatctt gttgagtctc aagaaggttt ttttgctaat gaacttataa
     6841 taaatctata taagaaatga cacagcgtat atttataata ggaggagaat ggatatattt
     6901 taaaatatat tctggaccga aaacaataga aaatattttt attaatgata ttatgtgcaa
     6961 gataaatctt cttataaaac agagaatgat agattcattc ttctttgtaa gatatatgga
     7021 tc
//
