LOCUS       gnlProkkaCIOCCFKD_78   12302 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIOCCFKD_78.
ACCESSION   gnlProkkaCIOCCFKD_78
VERSION     gnlProkkaCIOCCFKD_78
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 07:23:37
            Original ID  :: gnl|Prokka|CIOCCFKD_78
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 72686
            Orig. end    :: 84988
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12302
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10354]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10354
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12302
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12302
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             190..1830
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 69.4;
                     E-value: 4.9e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg78_75"
                     /transl_table=11
                     /translation="MDTKALVTLCQKGNGQALSLLYENYSEKMLKVCLRYIPDPTIAQD
                     LLHDGFVIIFTSIHSLRNPEKLEYWMKKIMRNLALQYLNHANANPTIPLTDIPEEEEPA
                     ENPFCPDFISYDKMLDIVESLPEGYCKVFKLAVLEGLSHKEIGDLLGIAPHSSSSQLFR
                     AKILLKKMLAGYRVFIVLTVLLLFPTLYDYLYREKKSIRENRLSKVSSRQAGSTQQTKK
                     TDTPRTDEQCHTKENLNKRERIIPPVPVSTEWPLAIPTMKDSIHKYPIPSPFTGQTITN
                     RQMAFVFSPSLMPPTRKKKSGKWKLMLAGSLGPQLAQNLYKLIATPHTDGISSDFPQQV
                     STWEEYYSYLHTRYQQGTLGKDSIGLMQIAQNNSGRIVENQQHHAPIVVGLSLSKKLNE
                     RWSLETGLQYTLLRSEFTTGEAFRIQDNQKLHYIGIPLRLSYRFWHYKRFSGYATAGIQ
                     VDIPIKGTLQSFHVTDSIPHKLDSQPVSAPWQWSVNTSIGIQYRLTPQAGIYLEPTVNY
                     YIPDGSQLRTIRKEHPFTFTLPVGLRISW"
     CDS             1912..2691
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 56.5; E-value:
                     4.7e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_76"
                     /transl_table=11
                     /translation="MQKRHTDRESYFDEQSQTSKNYYIPYIKEVIGHIPDKVLEVGCGE
                     GGNLLPFAKAGCRVMGVDIDAMRIEQARTFFTQRHQQGQFIATDIFQLEDKATNFPLIL
                     LHDVIEHIRDKERFLSGLQKHLSADGAVFVGFPAWQMPFGGHQQIAHSHIVSHFPFLHL
                     LPRTLYRWILRLCGEQERVITELLDIKSTGCTIELFNRIARQANYQIIDRRLYLINPHY
                     KIKFGLSPTKAQRSYCCYPVHKKLLLYKLLLHIKERD"
     CDS             complement(2910..3395)
                     /locus_tag="ctg78_77"
                     /transl_table=11
                     /translation="MKIHEGKCTEKILKERERIGSRLAILRKKRNMTQEELANLCGVNR
                     VNIAKIEKGAYNVSIDILSKVTSALGFVIDIKVDSSVCPTHFSQRKPVKLVIGKDYYVS
                     FGNNEAHRCKLVDIPEMYQGQRIKIETPTPRGSITHILFADEIGTTPDEAVMNQVTM"
     CDS             4816..7644
                     /locus_tag="ctg78_78"
                     /transl_table=11
                     /translation="MKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFN
                     KNGVKDVYEDPSAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLW
                     KDGIGAIDEHLNGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNE
                     GIRGVESYRATNFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQR
                     WGRYEEVYGESPYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQM
                     SPREVENIHIYPFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVV
                     SDSDAVEYLYTKHGTVKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEE
                     VINDRVRDILRVKFLIGLFDAPYQTDLAGADREVEKEENEAIALQASHESVVLLKNADE
                     LLPLDINSTKKIAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKGKAEVLYTKGC
                     DLVDAHWPESEIIDYPLTDDEQAEIDKAVENARQADVAVVVLGGGQRTCGENKSRTSLD
                     LPGRQLQLLQAIQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADIL
                     FGDYNPGGKLTVTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGL
                     SYTTFEYSDLDITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNL
                     AGFQRIHLEPGEAQELSFTIDRKHLELLDADMKWVVEPGDFVLMTGASSEDIRLNGTLT
                     VEDYQTRAKAIEAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKV
                     DKVAIAFTRDNNLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVL
                     NDDRVSIAEVKF"
     CDS             7746..8873
                     /locus_tag="ctg78_79"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGGQDELAMLVGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSATLPNPSYLVPSEDGKFVYAVSEMNDSTAALSSLAFDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDNPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGRLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKKDGIAIFAVNPENGTLTKVGYQPTGIHPRNFNITPNGKYLLAACRNSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             8944..9993
                     /locus_tag="ctg78_80"
                     /transl_table=11
                     /translation="MKKNILMLSALFLSTTALAQTDVTTGVMRGKDYGVTYMLPKTEIE
                     IVLQATKHTYTPGEFCRYADRYLRLNNVSAESEEFWTLDKIETRIAGVPDKDNIYFVKM
                     KDKTVAPLMELTEDGIVRSINIPFSDKPATKTPEAKATESSIDPRSFLTEEILMSNSSA
                     KMAELVAKEIYSIRESKNALLRGEADNMPKDGAQLKLMLDNLNQQETAMTEMFSGKIKK
                     EPKTFTIRLTPKEMKDEVAFRFSRKLGVVANNDLAGEPYYISVTDLKSPDVSATEEGKK
                     KVDGVAYNLPGKAQVTLVYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFDTAT
                     GGLIKVDRE"
     CDS             complement(10001..10354)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_81"
                     /sec_met_domain="PqqD_RRE (E-value: 7.5e-10, bitscore:
                     30.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.3e-16, bitscore: 53.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEIPEGKVSLLDAVPVRCGHITTEWEGECAVLAYPRFKYEWMRR
                     FLLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIPRVTAYVMQ
                     LRKDGFIQLTIRN"
     CDS             complement(10374..11765)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 100.6; E-value: 1.2e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg78_82"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMAAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEE
                     PNIQK"
     CDS             complement(11919..12302)
                     /locus_tag="ctg78_83"
                     /transl_table=11
                     /translation="MLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRKTT
                     DFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEAPQ
                     SEAPAATTPAEAPAPAAEAPAAE"
ORIGIN
        1 caccaacatt cccactccgg tggtgaagct gcctcaagga tttacactga acagcatcaa
       61 ctatgtactg aaaggcattt gtccggactg tgcagcagaa gtcaaccggg aggcttagtt
      121 aaaaaataaa aatccatgca gtcattcatg ttcttctcta tccttaagaa ataacattga
      181 gacaaacaca tggatacaaa agctcttgtc actttatgcc agaagggaaa cgggcaggcc
      241 ttgagcctgc tctacgaaaa ctattcagag aaaatgctga aagtatgcct acgctatatt
      301 cccgacccaa cgatagccca agatcttctt cacgacggtt ttgtcatcat attcacttcc
      361 attcattcgc tgcgcaaccc ggagaaactg gaatactgga tgaaaaagat tatgagaaac
      421 ctggcactgc aatacctcaa ccatgccaat gccaacccca ccatcccatt gacagatatt
      481 ccggaagagg aagagcctgc tgaaaatcct ttttgtccgg atttcatttc gtacgataag
      541 atgctggata tagtggagag ccttccggag ggctactgca aggtatttaa actggcagta
      601 ctggaaggat tgtcccacaa agaaatcgga gatttactgg gtatagcgcc acactcctct
      661 tcctcccaat tgttccgggc gaaaatttta cttaaaaaga tgctggcagg ataccgtgta
      721 ttcattgttt tgacagtatt gcttctcttt ccaacgctgt atgactatct gtacagagag
      781 aaaaagagta tcagggaaaa ccgtttgtcc aaagtttctt ccaggcaagc cgggagtacg
      841 caacaaacaa agaaaaccga tactccccga accgacgaac aatgccatac caaagaaaat
      901 ctgaacaaaa gggaacgaat catccctccc gttccagttt ccacagaatg gccccttgcc
      961 atacccacaa tgaaagatag tatccacaaa tatcccatac cttctccatt caccggacag
     1021 accatcacca accgacagat ggctttcgtc ttctcccctt ccctgatgcc gccaacccgc
     1081 aagaagaaat ccggaaaatg gaagttgatg ctggcaggtt cactcggacc gcaactggca
     1141 cagaacttat ataagctgat tgccactcca cataccgacg gcatttcaag tgacttccct
     1201 caacaagtca gcacgtggga agagtattat tcttatctgc acacccgcta tcagcagggt
     1261 actctgggaa aagattccat cggactcatg cagattgccc agaataacag cggcaggatt
     1321 gttgagaacc agcaacatca tgcccccatc gtcgtgggac tctctctcag caagaaattg
     1381 aatgagcgtt ggagcctgga aaccggattg caatatacgc ttctcaggtc ggagttcact
     1441 accggcgaag cattccgcat tcaagacaac cagaagctac attatatcgg catccctctc
     1501 cggctttcct accgtttctg gcattacaaa cgtttctccg gttatgccac ggcaggcata
     1561 caggtggata tccccataaa aggaacactc caaagcttcc atgtcacgga cagtattcca
     1621 cacaagctcg acagccagcc ggtaagtgct ccctggcagt ggtcggtcaa cacaagtata
     1681 ggcatacaat atcgcctcac accccaggca ggcatctatc tggagccgac tgtaaactat
     1741 tatatccccg acggcagcca actgcgcacc atccgaaagg aacacccgtt cacattcacc
     1801 ctcccggtag gcctccgcat ttcctggtaa aaaaacgatg cgccacgcag tcttttaccc
     1861 gactgattat ctatttatat ggataatcaa actcaagaag gaacaaagaa catgcagaaa
     1921 cgacataccg accgggaaag ctactttgat gaacagtcac agaccagcaa gaactattat
     1981 atcccctaca taaaggaagt catcggacac atccccgata aagtgctgga agtgggctgt
     2041 ggagagggag gcaatctgct tccctttgcc aaagccggtt gccgggtgat gggcgtagac
     2101 attgatgcca tgcgaataga gcaagccagg accttcttca cccaaaggca tcagcaggga
     2161 cagttcattg ccaccgacat tttccagctt gaggacaagg ctacgaattt tcccctgatt
     2221 cttctacacg atgtgataga gcatatcaga gacaaagaac ggttcctctc cggcctacaa
     2281 aaacatttgt ctgccgacgg agctgtattt gtaggatttc ccgcctggca aatgccattc
     2341 ggaggccacc agcagatagc acacagccac attgtttcac atttcccttt tctccacctc
     2401 cttccccgca ctttatacag atggatatta agactatgcg gtgagcagga acgcgtaatc
     2461 acggagctac tggatataaa gagcaccgga tgcaccatcg aactgttcaa tcgcatcgcc
     2521 cggcaagcca actatcaaat cattgaccgg agactgtacc ttataaaccc acattataaa
     2581 atcaaattcg gcttgtcccc cacgaaggct caacggagtt attgctgcta tcccgtacat
     2641 aagaaacttc ttttgtacaa gttgctttta catattaaag aaagggacta aaactgttaa
     2701 tcactactga tttcccagct ttagaattga ttccgaacca tcaatttaag attatatatt
     2761 cagaagaaac cattaaattt ctgaatagcc ctgatgaaag agggtgtgta gaaaccctca
     2821 taaactaaaa aatcaccctc gctgcagatg gttgtagcga aggtgatttc aataaaaggg
     2881 gaacttgcac ttcctccctt ttaatgtttt tacatcgtta cttggttcat tacagcctcg
     2941 tcaggtgtcg ttcctatttc atcggcaaat aatatgtggg tgatagaccc tctcggggtc
     3001 ggagtttcga ttttaattct ttgaccttgg tacatctccg gaatatcaac cagcttacat
     3061 ctatgggctt cgttattgcc aaaactgaca taatagtctt tccctattac cagctttaca
     3121 ggtttacgtt gagagaaatg agtcggacaa acagagctat ccacttttat atctatcaca
     3181 aaaccaagag cggatgttac cttagatagt atatcaatgc tcacattata agcccctttc
     3241 tctatcttgg ctatattaac acgattaaca ccacaaagat tagccaattc ctcttgggtc
     3301 atatttctct tcttgcgaag aatggctaac cgactaccaa tccgttcacg ttctttcaaa
     3361 atcttctctg tacattttcc ttcgtgaatt ttcataaatc tgttgcagaa tttaaagtgt
     3421 tgcccccact tctaatagtt attggttttt gaacagacaa aagtagatat taattttgaa
     3481 ttgtagcaca tttactacaa ctattttcta aatgaatata aaaggtaggg ggagtagaag
     3541 aaaagaaaaa gcccctgaat tactggaatt caaggactta caaacttctt tttactatat
     3601 ccgtggagct ggagggaatc gaaccctcgt ccaaacgagg aaatcataag ctttctacat
     3661 gcttatcttt gcctaaattt tcgtgcagcg gcagaaccaa agccatcaac cgttgcctta
     3721 tcctctagat tttcacccgc gccacgaggc tgacacgaac tatccccgat ttgactgcac
     3781 cactttatcg gaatgcttcg gagcaacagc ttccgagtga tgtcacgtcc cagcacctgg
     3841 tgccgggatt aagcttcaat ctactatact tcgattaagc agcgagagcg taacgagttt
     3901 cgccagataa aattttgagg actgagatta aagtgcaaat caacgacgca ctgcatgctt
     3961 acttaccatt tctgcccgct gtcaaatcca gtcaacccca tgactttgta acggtctgaa
     4021 atttaaaaga ttgcgtaact cattgctaag tagggagggt gaaaaaggga taaatgctac
     4081 tttatttttc atcctctacc gctttctttg gcccaaagat acatattctt ttattagcaa
     4141 tcaccatata tttacaaata ttagctaata ctgacttttc gtgataaaaa caataatctt
     4201 ccatacatag aatatgtgca ccccattgtc atcaatgttc aaacagctac caaagccagt
     4261 atccgttgac agaattaccc cctgcaagag ggaatatcta tcttctgtaa tggatatttg
     4321 cacaaaagag atgggaagtt aacggaaaaa gtctctgaag ttaactgaaa aaccggaaag
     4381 aattaaggaa gcaatctatc ccaaactttg gtttttccat acccaacctt gggatgtcta
     4441 aaccaaggtt tggtttagac atcccaaggt tgaaaagaaa gttcttccgt acaagcaaca
     4501 attccgccaa cagattccta ttatataaat acaccctcgt ttaacagatg tagccgtaat
     4561 acttgtatac accgcgattg catctacttt tcaggttatt atagtgttct ttctttttaa
     4621 aagtgaatga tatgtttcgt ctaataatga tttgaattcc ccggtagcgt cttggaggat
     4681 atttttagta agaggaagac ccttcggaca ataaaagccg atacttcgga ctattttatc
     4741 cctttatttc acacattagc cgtatttttg tcaacaaaag aaacaataat aaccaagaga
     4801 tttttagaac atatcatgaa gaaccttatt gccctaaccc tgctgcttgg aggaagcaca
     4861 ctgctctgcg cacaaaagcc tgccaaaaca ccggcaacct acaagccggt gaaaagtgaa
     4921 atgtaccgca aaggttggat agacttcaac aaaaacggag tgaaagacgt gtacgaagac
     4981 ccctccgccc cgctcgaagc acgcatcgaa aacctgctgc aacagatgac gctggacgaa
     5041 aagacctgcc aaatggtcac cctctacggc tacaaacgcg tactgaaaga cgacctcccc
     5101 acccccgaat ggaaagagct gctctggaaa gacggcatcg gcgccatcga cgaacacctg
     5161 aacggcttcc agcaatgggg gctgcctccc tcggacaatg cctacgtctg gcccgcctcg
     5221 cgccacgcct gggcactgaa cgaggtgcaa cggttctttg tggaagatac ccgtctcggc
     5281 atccccgtag actttaccaa cgaaggcata cgcggcgtgg aaagctaccg cgccaccaac
     5341 ttccccaccc aactgggact gggacatacc tggaaccgtg aactgattcg ccaagtagga
     5401 ctcatcaccg gacgcgaagc ccgcatgctg ggctacacca acgtctacgc ccccatcctc
     5461 gacgtaggac gcgaccagcg ctggggacgc tacgaagaag tttacggcga atctccctac
     5521 ctcgtagccg aactgggcat cgaaatggtg cgcggcttgc agcacaacca ccaagtggcc
     5581 gccaccggca agcactttgc cgcttacagt aacaacaaag gcgcccgcga aggcatggca
     5641 cgcgtggacc cgcaaatgtc gccgcgcgaa gtggagaaca tacacatcta ccctttcaaa
     5701 cgcgtcatcc gggaagccgg catgctgggc gtaatgagtt cgtacaacga ttacgacggc
     5761 atccccgtgc agggcagcta ctactggctc accacccgcc tgcgtggcga aatgggattc
     5821 cgtggctacg tcgtatccga cagtgacgcc gtagaatacc tctacaccaa gcacggcacc
     5881 gtcaaagaca tgaaagaagc cgtccgccaa agcgtggaag ccgggctgaa cgtacgctgc
     5941 accttccgct cgcccgactc cttcgtcctt cccctccgcg aactagtgaa ggaaggcgga
     6001 ctgagcgaag aagtcattaa cgaccgtgtg cgcgacatcc tccgggtaaa gttcctcatc
     6061 ggtctgttcg atgcccccta ccagacagac cttgccggtg ccgaccgtga agtggaaaaa
     6121 gaagagaacg aagccatcgc cttgcaggca tcccacgagt ccgtcgttct gctgaagaat
     6181 gccgatgagc tgttgccctt agacatcaac tccaccaaga agattgccgt ctgtggtccc
     6241 aatgccaatg aagaaggcta cgcgctgacc cattacggcc cacttgccgt agaggtgacc
     6301 actgtactgg aaggcattca agaaaagaca aaaggcaagg cagaggtgct ctacaccaaa
     6361 ggctgcgacc tagtggatgc ccactggccc gaaagtgaaa tcatagacta tcctctgacc
     6421 gacgacgagc aagccgagat agacaaagcc gtagaaaatg cccgccaagc tgatgttgcc
     6481 gtcgtagtat tgggcggcgg acaacgcacc tgcggcgaaa acaaatcgcg caccagcctc
     6541 gacctgcccg gccggcagtt gcaactgctt caagccatac aagccacggg caagcccgtc
     6601 gtactgatac tcatcaacgg acgcccgctc tccatcaact gggcagacaa gttcgtcccc
     6661 gctatcctcg aagcctggta tcccggctcc aaaggcggaa cagccctggc cgacatcctc
     6721 ttcggcgact acaaccccgg tggaaagctg acggtgacct tccccaagac cgtagggcaa
     6781 atccccttca acttcccctg caaaccttct tcacagatag acggcggtaa gaatccggga
     6841 cctacgggca acatgtcacg catcaacgga gcactctacc ccttcggtta cggcttgagc
     6901 tacaccacct tcgagtactc cgacctcgac atcacccccc gagtcatcac cccgaacgag
     6961 tctgccaccg tccgcctgaa ggtgaccaac accggcaaac gtgccggaga tgaagtagtg
     7021 caactctata tccgcgacgt actgagcagc atcaccacct acgaaaagaa tcttgcaggc
     7081 ttccagcgca tccacctcga accgggcgaa gcccaggagc tgtccttcac catcgaccgc
     7141 aagcacctgg agcttctgga cgccgacatg aaatgggtgg tggaacccgg cgacttcgtg
     7201 ctcatgaccg gcgcctcttc cgaagacatc cgcctgaacg gaacgctgac cgtagaagac
     7261 taccagaccc gtgccaaagc cattgaagcc caaaaaccag caaagcgtgt gagtgccagc
     7321 accaacccag aggatgccga aaacgtgctc gacgaaaaaa tcaataccgc atggcaagga
     7381 aataagggag attatattac ctttgccttg aagaacggag ccaaggtaga taaagttgcc
     7441 attgccttta cacgtgacaa caacctgccg gcaaccttcg aaatccagct ctcgggcggt
     7501 ggcggacagt tcctcaccgt atattcgggc accgtcagcg aatacggcaa actgatttcc
     7561 tatccgttca aaggcactac cgccagcgac ctccgcatcg tgctgaacga tgaccgcgtc
     7621 agtattgccg aagttaaatt ttaatgtgct aatgtgccaa tatgctaatg taccaatgac
     7681 catgcagcat atacagcgca gccaattagc acattagcat attggcacat taacacatta
     7741 aattaatgaa aacacttctt ttctgtatgc tcggattagg tttgacagca tgtggctctt
     7801 ctccaaaggg cactaacggt ggccaggacg aacttgccat gctggtgggt acttacacga
     7861 atggttcaag caagggtatc tataccttcc gctttaatca agagacggga acagccgtcc
     7921 cgctcagttc agcgacattg cccaatccct cctacctcgt cccctcggaa gatggcaaat
     7981 ttgtctatgc cgtcagtgaa atgaacgaca gcacagcagc cctcagctcc cttgccttcg
     8041 accgggaaac gggagaattg cgcctgctga acaccgttcc caccttcggc gccgacccct
     8101 gctacgtggc caccaatggc cgggaagtgt tgactgccaa ctacagcggt ggaaccatgt
     8161 ccgtctttcc tttacagaaa gacggcactt tggctcctgc agacacgctc tttcaaggct
     8221 ctgccaccgg tcccgatgcc atacggcaag ccactcccca catccattgc acggtctttt
     8281 cacctgacgg aaaatacatc tttgctaccg atttcagtgc cgaccgcatc ctgcgatttg
     8341 tgatgcaccc cgacaaccct atccctcatg cttctctgga agccgttgac attgaggcag
     8401 attccggccc gcgccatctg acattcagcc ctaacgggaa gtttgcctat ctcatcaccg
     8461 aactgtccgg taaggtcatt gccttcagtt atgacgacgg ccgcctggaa caaatacaga
     8521 ctatcacagc cgacaccgta gccgcccgtg gaagtgcaga catccacctc agtccggatg
     8581 ggaaatacct ctacgccagc aaccgtctga aaaaagacgg catcgccatc tttgccgtga
     8641 atcccgaaaa tgggaccttg acaaaggtag gttatcagcc caccggcatc catccccgca
     8701 acttcaacat cacgcccaac ggtaaatact tgcttgccgc ctgccgcaac agcaatgtta
     8761 ttcaagtata caaacgaaac gaagttaccg gactcttgga agatactcat caggacattg
     8821 tagtcgacat gccggtttgc gtacagttcg tcagctctgt taataattta taaagcaata
     8881 tttagcaaag ataacttcat taactttgtc ccttagctaa atcagtctaa acgaatgtac
     8941 attatgaaga agaatatatt gatgctctca gctctgttct tgtctaccac tgccctggcg
     9001 caaacagacg taaccaccgg cgtgatgcgt ggcaaagact acggagtgac ctatatgtta
     9061 cccaaaacag aaatagaaat cgtattgcaa gccaccaagc atacctacac tcctggagaa
     9121 ttttgcagat atgccgaccg ctatctgcgt ctcaacaacg tgtctgccga atccgaggag
     9181 ttctggacac tggataagat agaaacccgc atagccggtg taccggataa ggacaacatc
     9241 tatttcgtga agatgaaaga caagaccgta gcacccctta tggagcttac cgaagacgga
     9301 attgtccgct ccatcaacat tccgttcagc gacaagcctg ctaccaagac gcccgaagcc
     9361 aaagccaccg aaagcagcat tgacccacgc agttttctga cggaagaaat actgatgtcc
     9421 aattccagtg ccaagatggc cgagctggtg gccaaggaaa tatacagcat ccgcgaaagc
     9481 aagaatgccc tcctgcgcgg cgaagcagac aatatgccca aggacggcgc ccaactcaag
     9541 ctgatgctcg acaatctgaa ccagcaggaa acggctatga cggaaatgtt ctcgggcaaa
     9601 ataaagaaag aacccaagac attcaccatc cggctgacgc ctaaagagat gaaagatgaa
     9661 gtggctttcc gtttttcccg aaagctggga gtggtggcca ataatgacct tgccggtgaa
     9721 ccgtattata tcagcgtcac cgacctcaaa agtcccgatg tatctgccac cgaggaaggc
     9781 aaaaagaaag tggacggtgt agcctataac cttccgggca aggcacaagt gacattggtg
     9841 tataacaata agaaattgtt tgatgaccaa cttcccatta cccaattcgg caccgtagaa
     9901 tacctcgcac cggtactgtt caacaagaat tctaccatca aagtgctgtt tgatacggca
     9961 acgggaggat tgataaaagt ggatagggaa taaaggaatt ctaattccgg attgtcaact
    10021 ggataaatcc atccttacgc aactgcatta cgtaggcggt gacccgggga atataattct
    10081 cttcctcccc aaagtgcctg gcaagcagag agatgatttc acgcacggta cgatgtccat
    10141 ctatcagatt ccagacagct gtgccgtgtt cttccagcct cacatggatg tcaggagaca
    10201 tccccttcgg caataaaaaa cgacgcatcc attcgtattt aaaccgtggg taggcgagta
    10261 cggcgcactc accttcccat tcggttgtta tatgtccaca gcggaccgga acagcgtcca
    10321 acagacttac ttttccttcg ggtatttcca tcatatggta tccgcttttc ctattatttc
    10381 tgaatattag gctcttccag cttataacca tacttcttgt ctgccttctt cagcagtagg
    10441 gccactataa gggacaagca ggcaataccg gtaaaaatgc acataggcac cgtatagtca
    10501 tacatattcg ttccatctgg tttcttaccg gatatacaat aggcatcaag cacccaccct
    10561 atcaatgtag gaatacccca aagaccgata ttctggataa agaaaatcaa tgcgtatgcc
    10621 gtacccaact ggcttaccgg gaatatcttg gccacagccg gccacatggc agaaggtacc
    10681 agcgagaaag cgatacccaa aattatcatc agcacaatag ctaccagcca atagtttata
    10741 tcgggaatag cataaatgaa atgcacacat atcagcatgg ccgagcccag cagcatgata
    10801 gatgcggact tgccccgctt gtcaatgaaa ccgccaaaga ccggagtcag aatcagcgct
    10861 cccaatgccg gaagtccggc aaatgtaccg gccacattct cattgatacc gtatttgata
    10921 atcatcaact cggaagcaaa cttctggaat gggaatacac aagagtagaa caatacacac
    10981 agcaatgcta tcagccagaa accgggattg accagaatat tcttcacatc cttaaaagag
    11041 aacttctctt cctcatcttc cgtaccggca gcaatggcag cagcttccat ctgtttgtcc
    11101 agcttcttgt ccatcactgc aaagatgaag aaagcaatca taccgcccaa caacagaacc
    11161 aaacccaaca acaccggtgt ggaaataccg aaagcacggg ccaaaggaat ggctacggca
    11221 taaccggctt gcgaaccgat acgtgctaaa gcgacttgta cccccatagc cgtggcaagc
    11281 tctttcccct taaaccactt ggctatgatt ttggaaactg taataccggc gacctccgct
    11341 cctactccaa aaatggaata accggcaaaa gcaacaaaca cacccgtttt atagccaaat
    11401 atttcattga ttccgaataa agtcgcgtcg gcaccggcaa gtcccgtcat tgcatagtat
    11461 tcaagtgctg taccacctac catcaggata gttgccagct ttccggtgaa acggatacca
    11521 aagcggtcga ggattaatcc tccccaaatc aacatcagga aaaaaacatt cagaaaacta
    11581 taaccaccgg taaagaatcc gaaatcggta ctcgaccaag ccaagtccgt ttccaacatt
    11641 gtcttcaacg gtgctaccac gtcgtttaca taataagctg ccatcatcgt gaaggcaaca
    11701 atcaccaatg ccccccaacg ggtagccttg gaatcattca atttaagttt gagttgttct
    11761 gtcattgtac tatttggatt tcaatttatt aatcagattg cataaattgc tgacaaaggt
    11821 aaataaatac ttcatcaaaa cgaaaaaagg ctgacacctt ttcagtatca acctttctct
    11881 tatttttcca agcgggagtc atccgcaata tccttatctt attctgctgc aggggcttct
    11941 gctgcaggag caggagcttc agccggagtt gtagctgcag gggcctccga ttgcggagct
    12001 tctgtaccta cgggcatgtt ataaggatta gttttttctt cttgttgcgc ctgttccaga
    12061 atcacatcac cgcccttgcc tgtggaagaa ggaatagtgt aagcagaaac aatactgaag
    12121 actaccataa cagctgccag agtccaggtt gctttttcca aaaagtccgt agtcttgcgc
    12181 acacccataa tttggttgga tgatgaaaag cctgatgcca gaccgcctcc tttagaattt
    12241 tgaatcaata caatgaagca catcagcaca gatgcaatca acattaagat aactaataat
    12301 aa
//
