LOCUS       gnlProkkaBBKNCJAN_215  13891 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BBKNCJAN_215.
ACCESSION   gnlProkkaBBKNCJAN_215
VERSION     gnlProkkaBBKNCJAN_215
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:20:46
            Original ID  :: gnl|Prokka|BBKNCJAN_215
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13891
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13891
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3546:3891]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3547..3891
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13891
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13891
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             326..1837
                     /locus_tag="ctg215_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             1910..2977
                     /locus_tag="ctg215_2"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSTEPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSKSSSDKKTAPAPTVLSKIANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTRD
                     KEEKTFTVRLTPDREFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             3001..3285
                     /locus_tag="ctg215_3"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLSEGREASRLRRERANDKLKHLNRTNEPYPLP
                     NTTPEEMGRIIHDSEKKKEKDSNYFVWGTLIIMGVLIATAVIFWAIFLN"
     CDS             complement(3547..3891)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg215_4"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-10, bitscore:
                     32.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-17, bitscore: 55.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPAGMSKELHVRLEEHGTAVWELIDGKRTVREIIEELADHFQNEAGYESRVSAYLSQMQ
                     KDGFIKLFIN"
     CDS             complement(3987..5375)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 95.3; E-value: 4.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg215_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGYTDEGGAFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSLMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5623..6018)
                     /locus_tag="ctg215_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(6025..6798)
                     /locus_tag="ctg215_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6804..7331)
                     /locus_tag="ctg215_8"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7318..8559)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 389.3; E-value:
                     4.4e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg215_9"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPVIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8569..9663)
                     /locus_tag="ctg215_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9668..10708)
                     /locus_tag="ctg215_11"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             complement(10727..11737)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg215_12"
                     /sec_met_domain="PF04055 (E-value: 5.1e-18, bitscore: 57.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
ORIGIN
        1 aaaaagcaaa catatctaca acttttaata ggattaagaa agaagaagac agttgaaata
       61 aaaaagagat taccaccaaa tttgacgaag aaccagaaat ctttttcagg gagaaataaa
      121 agtaagttca taatggtgca gcattgaatt attttttggc ggagttattc taacacttaa
      181 tagttcaaaa gcagatattt ctttgaccaa aagatagaac taatgatgaa ttaaaagttg
      241 caattatggt tttcttccca caacaaacgg gaaaagtcag aagaatcatg tacatttgta
      301 atccgaaaac taaaagaaca tcgcaatgaa aatatttcca agcagcagta tcaagaaatt
      361 ggacgcttat accattgaga acgaacctat tgcatcaatc gatctgatgg aacgtgcagc
      421 aaccgtatta acaaaagcca tcacagacag atggaatacg gaaacgccgg tcactatctt
      481 tgccggacca gggaataatg gcggagacgc tctcgccgta gcccgcatga tggctgaaaa
      541 aggatataaa atcgaggtat ttctcttcaa cacgaaagga gaactttcac ccgactgcca
      601 gaccaataaa gaactggtag aaatgatgga agaagtaaaa ttccacgaaa tcagtaccca
      661 attcgtacct cccgtcctga cgcccgatca tctggtaatc gacggattat tcggttcagg
      721 tctgaacaaa ccgttgagcg gtggattcgc tgccgtagtg aaatacatca attcctcccc
      781 tgccatggta gtagccatcg acattccttc cggactgatg ggagaagaaa atacattcaa
      841 cgtaaaagct aatattatcc gcgccgacgt aactttcagt ctgcaactgc cgaagctcgc
      901 ctttcttttc gcagagaaca ctgaatttgt cggagaatgg gaagtgctgg atatccaatt
      961 aagcgaagac ggtattgaag agatggagac taactacgaa atgttggaaa tagaagaaat
     1021 ccgttcactc atcaagccac gcaaacagtt tgcccacaag gggaacttcg gccatgcact
     1081 attgattgcc ggttcaaaag gaatggcagg agcctctgtt ctcgctgccc gcgcctgcct
     1141 ccgttcggga gtagggttgc tgactgttca tgcaccaatg tgcaacaacg acatcttgca
     1201 gacctccata cccgaagcaa tcgtagaaac cgacatcaac gaaacctgtt ttgccgtacc
     1261 taccgatacg gacgactacc aagcagtcgg catcggcccg ggactgggac gaaacgagga
     1321 aacggaagct gccttgttgg agcaactgga acactgccag actcctgttg tagtggatgc
     1381 cgacgctctt aatatcctcg ccaaccaccg ccataccctt acccacctgc cgaagggttc
     1441 catcctcacc ccgcatccga aagaactgga acgtctgacc ggcaaatgcc aggactctta
     1501 cgaacgtctg atgaaggctt gcgaactggc ccgtgccgcc catgtccaca ttattttaaa
     1561 aggagcctac tccgccatca tcacccccga aggtaaatgt ttcttcaacc caaccggaaa
     1621 tccgggaatg gcaaccggag gtagcggtga cgtactgacc ggagtaatcc tggcgctgct
     1681 tgcccaaggt tatcccaccg aagaagccgc taaaatcggc acttacattc acggattggc
     1741 gggcgatgtc gctcaaaaga agcaaggaat gatcggaatg atcgcaagcg atattatcac
     1801 ctgtctgccg acagcatggc gacttgtaag cgaataaaag ttaagaactt acagtttttt
     1861 caataacttc attaactttg ttttcaaaac cagttaaaaa gaaccgaata tgaaaaagtt
     1921 gattatagca gcaggactac ttatgacaac gtccgcctat gcacaaaccg aagtactgac
     1981 aggggttacc cggggaaaag attacggagt agtctacagt cttcccaaaa cccaaataga
     2041 gcttgaaata aaagccaaca aagtcaacta tactccagga gaattcagca aatacgctga
     2101 tcgttacctg cgattgacca acgtctccac cgaacccgaa gagtattggg aactggctag
     2161 tgtgaaggtg aaatccgtag gtgtacccaa cagcgaaact acttacttcg taaaattgaa
     2221 ggataaaaca gtagcaccac tcatggaact gacagaggac ggcatcgtga aaaccatcaa
     2281 tgtgccttac agtaaaagca gttcagacaa gaaaacagct cctgctccca ctgtcctctc
     2341 aaaaatagcg aatccccgcg aattcctgac cgaagaaatt ctgatggcca gctctaccgc
     2401 gaagatggct gaactggtgg ctaaagagat ctataacatc cgcgaaagca agaatgcctt
     2461 attgcgcgga caagctgaca atatgccttc agacggagca cagcttaaaa ttatgcttga
     2521 taatctgaat gcacaggaag aagcaatgac gcaaatgttc tccggcactc gtgataagga
     2581 agagaagaca ttcaccgtcc gccttactcc ggacagggaa ttcaacaacg aagttgcttt
     2641 ccgcttctcc aagaaactgg gtgtagttgc caacaatgat ctagcaggaa ctccgtttta
     2701 tatcagcttg aaagacctga aatcagtcaa gatcccacag gaagacggta agaagaagaa
     2761 agatttggat ggaatcgcct acaacgtgcc cggacaagca atggttacat tgaccgacgg
     2821 taaaaagaaa ctttacgaag gtgaactccc tattactcaa ttcggtgtga tagaatatct
     2881 ggctcctgtc ttattcaata agaattctac aatcaaagtt tattttgatc cgaatacggg
     2941 aggattgtta aaagtggata gagaagaagg caaatagtaa acttctaaag ggcaaagaat
     3001 atgggtggtg aaggacacat gctcgacatg atacgtcggc ttagcgaagg gcgagaggct
     3061 tcccgtctac gccgtgaacg tgccaacgac aaactgaagc acttaaaccg caccaacgag
     3121 ccttatccac tgcccaacac cactcccgag gaaatgggac gtatcatcca cgactcggag
     3181 aaaaagaaag aaaaggacag caattatttc gtttggggga cgcttattat catgggagtc
     3241 ctcattgcaa ctgccgtgat attctgggct attttcctta attagataat ttattagatg
     3301 atagttgata aatgatagat gggagatgct tcctaaatga taagggatat tcagtaaata
     3361 agaaatataa gtaactaaag atattctcaa aatactaaaa aggtaactac atcattacga
     3421 atcagttgcc ttttttcata tctttaaacg ggatatttga taaacctcct taggaggctg
     3481 cactatcata taactagcta ttatgccgca tagtaactat catttatcac ctatcatcta
     3541 ataaagtcaa ttaataaaaa gttttataaa cccatctttc tgcatttgag aaagataagc
     3601 cgatacacga gactcgtatc ccgcttcatt ttgaaaatga tctgcgagtt cttctatgat
     3661 ttcacgaaca gtacgttttc catctatcag ttcccataca gccgtaccgt gttcttccaa
     3721 tcgcacatga agttctttcg acattcctgc cggtacaagg aagcgttgca tccacggata
     3781 tttaaaacgg ggaaaggaga gcacaatcgt ctccccttcc ctttctgctg taatatgttc
     3841 actgcgacag ggaatgacct ctaacaggtt gattttctct ttggcagcca taattctttt
     3901 ttttatttca gagcattaat actaaccctc ttttattttc aaaccttata ctctcgaatt
     3961 tataacgtta cttcgaattg taactgttac ttctggatat ttgcctcttc caaaccatat
     4021 cctttcttct tgttctctgc tttcaacatc aaagcaacaa tcagagcaag tacaccaaag
     4081 agagcaaaaa tagtcatcgg caatgtgtaa tcataagtct gtgcaccgtc taccaccgga
     4141 cctttgcaat aagtattcaa tacccatccg attaacaaag gaacacccat caggccccag
     4201 ttctgtaccc agaaaatcaa agcgtaagca gtacccagct gtttttccgg aataatcttc
     4261 ggaacagaag gccacatagc cgaaggcacc aatgagaaag caaatcccaa tataatcatt
     4321 ataatagtag caaaccacca tatattcagt ataggcaggg caaacatggt atgtacaaaa
     4381 attagcatca atgatccgat caccatcaat gtggctcctt taccgatacg gtcatataac
     4441 gaaccgaaca acggagtcag gataattgca ccaatcggca acaatccggg aatcgttccc
     4501 gccagtttcg gatctacatt atatttctgc accatcaagt cggcagcata tttgataaaa
     4561 gggaagacgg ccgagtagaa caatacgcac agcaatgcga tcaaccagaa tcccttattg
     4621 gtaatgatat acacaatatc tttcatacgg aacggttctt ccggttccaa accttctgca
     4681 tccaaagaag catccaattt cttatcatag aaagtataaa ggaagaaagc aatcgtaccc
     4741 acgcacaaca taatcagaca aaacaaaata ggagcaggaa tattggtatg gaatgcacca
     4801 ccctcgtccg tatatccgaa gaagtctgcc aaaggaactg tcaacaccat cgccagagtt
     4861 gtcccaatac gtgccgtagc catttcaagt cccatagcca atgccatttc cttgcccttg
     4921 aaccatttca ctataatctt ggaaacagtg ataccagcaa tctccacacc tacaccaaag
     4981 atagcatatc ccaatgcagc caacgtcacc tgtgttttga atccgaagag catggcacct
     5041 tccggaaaag tagtagaaat cgcatagtat ttcaatccac aaccaaacac catcaataag
     5101 caagctccca ttccggtgaa acgaactccc attttgtcca aaatgatacc accgaagatc
     5161 agcatcaata ggaatacatt aaaccacccg taagcgcttg tgaagaaacc ataatcaaga
     5221 ctatcccata gtagttcttt ctcaagcatg ggttttagag gagacattac gtcggtgagg
     5281 aaatagccgc atagcatagt aaatgcgacc aatgctagaa cactccatcg gagtacggcg
     5341 gagtcattca atttctgttt caaatgttct gtcattgtta tatttaaaaa agtagttaat
     5401 aatcttatac agccaacaaa ggtagttaaa tctcgtttgt ttctatcaca aagagattgt
     5461 ttttacaaga aaaagttaag tgcggattac actgaccacg cggaacattg aaaatccgtg
     5521 taatctgcgt aatccgcact taaatatcaa agaaatgcag catccgtctg caccttccca
     5581 ttaatggttt taccccaaag tcttacctga cgacggagtg aattactctg ctgcaggagc
     5641 aggagtttca gtagccggtg ccggagtttc tgtagcaggt gcattggtag caggagcttc
     5701 agtttgcggc gcagccgtac ctgcgggtaa gttatacggg ttagtctgtt gttctttctg
     5761 tgcctgttcc aacactgcgt ctttagcaac agcagagcga ggaactacat aagcagtagc
     5821 aatgctcatt acaaccataa agatggccag gccccatgtt gctttttcca gaaagtctgt
     5881 agtcttgcgc acgcccatga tggcgttaga tgaagagaaa ccagaagcaa gtccgcctcc
     5941 ttttgagttc tgaatcagca cgatgaaaca catcaacaag gctgcaataa ccattaagat
     6001 aacgaataat aagtacattt ttagttattt tgaattagcg ttaataatca atttctccaa
     6061 aaatctgatt tggtctgcaa agtaagcatt tttttttgga tatttcaagc ttaatttttt
     6121 aattatttca agagcttttg aatatcgttg ctgtttaaca tagatttttg ccaaagtttc
     6181 cgtaaaacag ctgtcatctt cctcttcttc cttcatcgtt tcttcttcgg taagttcgtc
     6241 cgaagaggtt ggcgaagatg gcatttcttc tcttaaaggt ttcatgcaga ggggagagtc
     6301 gctctcgctc ttttctataa agtcgtcaat cagttcgaag cctttgagtt tgggcgtttc
     6361 ttcagccggc tgttccgtgg ccggagtctc ctccaaaagg aaagaggtgt aatccatcga
     6421 atagtcgaaa ctggtccggg cagtcacctc ttcgggtact gtggacaaga aagcgtcgat
     6481 caatgctaat gtgcggtcta cggacggttc gtctttcagc acctccgtga gaggtactcc
     6541 ctttttccgt gcctgcacat catagcggtc accttcaatc aaccggaaca actgccgtct
     6601 gtctgcaatg taaagaactg ctttccgcag ttctccaccg aaactaatat catggagaat
     6661 atacagattc ttcagataca gcagacgaag tgactgaaaa tacggatacc tcgcaagaag
     6721 attgcgcagt tcgtacaaag tatccctatt cagcgtctcg ggatgctgaa tccattgttg
     6781 aaagttaaca gaagtcattt atattaccag tttgctacag ttgcattaaa aatttgatcg
     6841 gtgatctctt tagacatttc agcaatcaat ccgtcctgta cggcagtcaa caactgggta
     6901 gagtcgtagg tacggaacgc agaaaactgt tgttcaaagt cttcggcatg attggtgttg
     6961 ttgacaaaac gcacattgac ggtgatagtc aacttcgtct ccgaagaata accgtcggca
     7021 gatactgcct gattgtactg attgtaccct gtgatttctc cgtcaatctg caagtcggca
     7081 ttctgattcg gcttgagcag ttgcagacgg gtctgccgaa tgaagatatc tttcaggtcc
     7141 tcattgaatt tggttgccaa cggagcatat acatactccg acttgatcgg gaagtcggct
     7201 atcgaaatgg tctttacctt atcataattg atagacgatc cgttaaactt ataggaaaca
     7261 gtgcacgcaa tgactaccaa cggcaagccg aacagtagca aagggcgtat tattttctta
     7321 atccaattca tattctttta tttttctata aagtgtacgc tcggaaatat tcaagtcctt
     7381 ggccgcactc ttccgctttc cgtgatgcct ttcaagtgct ttgcgtatca tttctttttc
     7441 cacttcgtcc agtgacaaag gaggttcttc tacatattct tccgtgtctt gtatgtcatc
     7501 gtcatccttg caaaccgcag gctgcatggt atgaatgatc gcaggtaccg aaggctggtg
     7561 tgtcgtcact accggagtag taaccaccgt tcccacttgt cctacctgcc ccacctgtcc
     7621 ggcacgttcc gccatcaggt tgtgcaccat cttcttcagc tccgccactt cctggcgcat
     7681 atcaaacaga acagaataaa gaatctcccg ttcgctctca aagcttttac tctcacgcgt
     7741 tcccatcagc gcgggaagac gttgcgtatt ttgtgcggga agataattct gcaagatagc
     7801 agcagaaatc tccctgttgg tttcaatgat agatatttgc tcggtgatgt tcttcaactg
     7861 acgcacgttt ccgggccacg ggtaagccaa caactctttc ttcgcatcct ccgtcaactg
     7921 aataacaggc atccggtatt tctctgcaaa gtctgcggaa aacttacgga acaacaaaag
     7981 tacatcgtca ccacgttcac gcaaaggcgg tatctggata ggcaccgtat tcaaccggta
     8041 atataaatct tcacggaaac gtccttctgc aatcgcttgc gtcagattga cgtttgtagc
     8101 tgccaccaca cgcacatccg ttttttgtac tttggacgaa cctactttca taaactcgcc
     8161 actctccagt acacggagca aacgtgcctg ggtagacatc ggcaactccc ctacttcatc
     8221 aaggaaaata gtaccaccgt cggcttcgcc aaagtaccct ttccgttcgc caatcgcacc
     8281 ggtaaacgca cccttctcat gcccgaacag ttcggaatca atcgtgccct ccggaatagc
     8341 accacagttg acagcaatat actgtccgtg cttcctccgg ctatattgat gaataatctg
     8401 cggaaaactt tcttttccga ctccactttc tccggtaatc agcacagaca aatcggtagg
     8461 agctacctga atggcaacat ctatggcgcg cgacaatgct tcagtatttc caataatacc
     8521 gaaacgctgt ttcacttgtt gtatctctgc tctcgtcatc actcgttttt aatcttcgtc
     8581 tactgtatcc agcttcagtt tatcactatc gtcacgtttc tcgtaatact gtttacgcaa
     8641 cggattggca cgagccactt tttcccgctg acgattacgg aacacatcga tggcaacata
     8701 gattgcctga cggaaagaat cttcacaagc caatcccttg cctgcaatat cgtatgccgt
     8761 tccatgagcc ggagaagtac gtactaccgg caggcctgcc gtatagttca ccccgtcttc
     8821 catagccaag gccttgaacg gagccagccc ctgatcgtga tacatcgcca ggataccgtc
     8881 aaaatgagta taattgcccg aacccataaa gccgtcggcc gcataaggac cgtagcaaag
     8941 gattcctttc tcttccattt ctttcatggc agggataatc acttcctgct cttccattcc
     9001 caacaaacca ccgtctccgg catgaggatt gagagagagc accgcaatac gcggagcgcc
     9061 gataccgaaa tcctgtttca gacaacgatg gaatatcatc agtttctcct gaatcagttc
     9121 tttggtaatc gtagtcgcga tctctctgac agggatatgt gtcgtcacca aagccacccg
     9181 gaagtcattc ttcatcaaaa tcatcaatga cttatcacca ttgcccagac gttcttcgat
     9241 atattccgta tgtccgggga aggagaactc ttccgactga atcgtatgtt tgttgatcgg
     9301 agctgttacg ataacatcta tcaacccttc gcgatattct tcgatggcac gttccaaagc
     9361 ccccagcgca gctttaccgg cttcgggatc gggtttggaa aattccactt tcacctcatc
     9421 atccgtacag ttcaccacgc tcaaacggtt gtaccccgct tcggtagcag agttgacaat
     9481 gctgaaattg gtctgtatat ccagcgcttt gcgatgataa gccgctactt tcggtgagcc
     9541 ataaataatc ggagtacata gttccaacat cgtagggtcg gaaaatgtct taagaatcac
     9601 ctcatagccc accccgttaa tatctccttg ggtgatacct atccttatct tgttatcttc
     9661 catgttttta tttattagtt tgttccgctt ccttagatgc ttctcccaat ggaatctgct
     9721 tctgctgaac ttcattcgga agtttcagtg tatacagaga tgcttccatc tggcgtacca
     9781 ggttgcgttt cattttatca ggtgaataaa caaatatttc tgctgtaata attcgttggt
     9841 ttttctcgtc cagacgagta tgagacacat acggaccacc cataaagtcg cccttcatac
     9901 gccacaggcc acgtgcttcc attgtgtagc tgttctgtac attgatcgga cggacatcgg
     9961 tcagcaaact atcggtcgac atataaacgc cttccttgaa tccggggata ttggctttca
    10021 tcacggagtc acgtttgtgc acaaaatatt ctttggtaaa cgtatccttg tcagtgtacg
    10081 gataagagta catcacaaag ttacggtcgg cagtacctgt gttggtagaa gcccagaaga
    10141 aatcatcccc ggtctttgaa ttagccagtt cggcatccac ccagatgtcg catccgaaca
    10201 aactgtccac tttctgcgaa atgaaattac tgtgtttccc ttccaggaac gtaatctgac
    10261 ggttcatttc cgcacgggta aagaagtcga caatcgtctt tttgttctct tccacaaact
    10321 tctcgaactc ttcttcgttc ggagcctgga tagtcaatat catctgcgga ttggcatata
    10381 cgtccttcgc atatttgaac gaggctttcg tatatatatc ctgtatatct acaataataa
    10441 tgttacgtat caacttcagc gtagaatcat aatctttcgg cgaagtatac ataatccgga
    10501 aagaaggttc cgactgcggc aaaccgggca tatcagcatc gagcgcatca tgtaaagccc
    10561 ttccggcagc acgatcccaa acaccgtgat ctactacaac caaaagctcg taagcacgac
    10621 cactagaggt gtgatttcct ttcagaccac aagatgcaac gacaaaggct accaaagcga
    10681 tgcataaaat aaaagaatac tttttcatga tgttcggttt tatatattaa ctttcattat
    10741 ttttctcctg tttcgctgtc gacagcatac cgcaagcggc aaaaatatct tcgcccctgg
    10801 atgaacggat agtggtgaaa agtccgtgtg atgtcagata atcacgaaaa cgggtcatcg
    10861 tatccatatc cgccccctcg aggtctaccc ccggtatggc atgaaaacga atcagattca
    10921 ccctgcaatc cagcccgcga agaagtttca gcaactcttt ggcatagacc tgcgaatcat
    10981 tgagcccttt aaaaacaata tattcaaacg aaagtcgacg ttgtttacta aaatcatagt
    11041 tttttaacag ttccaccatt tcggtgattg aaaacgcctt ttccgccggc attaattcag
    11101 cacgctgaac ggtcagcgga gagtgaaggc tgatggcaag gtggcagtca ttttcttcga
    11161 taaaacgctg caatcctttc cgtaacccga cagtagaaag cgtgatacgc ttcggactcc
    11221 atgcgtaacc gtaggtagcg gtcagtagtt ccaatgcttt caatacctca tccaggttat
    11281 cgagcggctc gcccattccc atcattacga cattagtcag tttgtcccgt tccggcagcg
    11341 aatgaatctg gtttatgatc tggctggcgg tcaggttagc cgtatacccc tgtttaccgg
    11401 tcatacagaa cttacagttc atcttgcaac ctacttgtga cgacacgcac aacgttgccc
    11461 ggtcatcatc cggtatataa accgactcta caaaatggtt ctcacccact ttataaagat
    11521 acttcaccgt accatctaca gagcgcattt catctaccgg agcttccgct cccacctcat
    11581 agttctgctt gagcaactcc cggtgtttca atgacaaatt agtcatatca tcaatcgagg
    11641 ctaccttctt ttcgtaaagc caggatgcaa tctgcttggc agcaaagccg ggcataccca
    11701 gtctttttgt caatgattga agctctacaa gagtcattcc taaaagggga tatttagaca
    11761 ttcttctttc tgttgatagt ttatatctgc aaatgtaagg aaataaagtc gatttccgta
    11821 tagcaggaat gtaaaagtta acaaaaaagg gaagtatgcc tccgttatga ttcaaccacg
    11881 ctgatatatt gaagtagctt ttgcgccatt tcagaatcct cgccattctt tttcacttca
    11941 tgaccgtacg cctcacggaa acaagccagc gcctcttccc gttcattaca aaagctgtgc
    12001 aaaaccccta agttctgaca agccagaatc gtatcttctt cctcccatcc caaatacttc
    12061 tttcgcagtt cgaactctct gaagaaagcc tctttcgcca ttggataatt ctccaacttc
    12121 acataagcct gtgctttgta ataatatacc agacaggaag cattagggtc agtatcatcg
    12181 tgaaaatcca aagacgttgc aatacgaatc acgttatcat agtctttatt catgtaatac
    12241 tgctgcataa tatcacatct caatgcttca tagcggacag tcagttccgc cagacgcggt
    12301 ttttcgctga aatacatttc atgcagaaga gactcacgga agaataaagt agatgcctgc
    12361 tcatcgccac gttcattcat catccgtttg aattccctgc acagataata caactgttta
    12421 tgacaagcga cgatctgttt tttgctatct atctgtatag caatgtccaa cgcctgattc
    12481 atcagcatcc atgcttcatc gtatcgtttg atataataaa gacatttacc ctgcatacgc
    12541 aaacatttag ccactccacc ggacagtctg ccattcaatg actcgtgcat ttcagctact
    12601 ttccggaatt tctcggcagc actctcttcc tcatccttat agtaatcaca ataagccaga
    12661 tattcggaaa gttcaatgac ttctgcctga ctcttctcgt cagcagaagc cgcatgataa
    12721 tcaagcgccc tattcaaata gatcgccgct tcattgtatt gctcattgta gtaatatgcc
    12781 aaagctagat ttcgacaggt gttggcaatc tccagttccg gagtcggtac tatgttttcc
    12841 tgcatcacca atgctttcag gaaacagtcg catgccgttt cgtattcttc attacgggca
    12901 taccgacatc cctcattcat cttcaatacc gacttggcaa tgagtggcat ggcagcacct
    12961 tccatactct tctcactcac agcagctgcc gccttcgtca gatggaaaga actgctcaag
    13021 aaagtagcca tatcattagc aatgacagga attaaaaaag aatcgatctc atcaaagtcc
    13081 aattcggcat agacttcagg cgtaacttca ggattgtcgt tcatgatcgc cttccagcta
    13141 tcttccaaca gagaacgatt cgtacgatac agaatctcga aaatctccac atcacaaatc
    13201 caatccttca atatatccca ttcttgcatc ttatagcatt gataggtaat ctccacttta
    13261 tagcgatacg aatcatggta gcagaactgt ttcatgcgat agttataatc ggcaaaagtc
    13321 aacggatggg aaaggatctc ttcctcatcc agcagagcgg aaataatttc atggcgacta
    13381 tcatctatac attcgtcatc ttgagcgaaa tagcgttcga tcgcctctac catttgtgta
    13441 tcaccaatgc aatatcgtcc tcctttgttg gtgagccagc tgctcatttc cactctcaac
    13501 tgcgaccaaa gtatctgatt aatgtctgcc atgctcttca cttcatcttc ggtaaatcct
    13561 tctaaagtaa gtgaaagcat cagaagcgtt cttccaatct cttcggaacc ataatcagcc
    13621 gacaaacgcc gtagcacact gtcatagaat tgcccaacct cattgagccg gcaatatcca
    13681 cgcatatatt cattgagagc atcgtactga ccgaacgaaa ccagctcgtt gagcaataca
    13741 cttaaacagc gcggttgttt agccagcacc cacgaagcaa gaatatcttc ctgctgtgca
    13801 gacaaagcct tggagtaagt agacaaatat tgctttgaga acgacttggc atccgcctgt
    13861 gaaaagccat tcaactggaa atgagcgtag c
//
