LOCUS       c00048_gnlPro..        14877 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BBKNCJAN_48.
ACCESSION   c00048_gnlPro..
VERSION     c00048_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 11:00:22
            Original ID  :: gnl|Prokka|BBKNCJAN_48
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 23798
            Orig. end    :: 38675
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14877
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[33798:38010](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14212
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14877
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14877
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(331..1086)
                     /locus_tag="ctg48_23"
                     /transl_table=11
                     /translation="VLAKRIVPCLDIKDGQTVKGTNFVNLRQAGDPVELGRAYSEQGAD
                     ELVFLDITASHEGRKTFTELVKRIAANINIPFTVGGGINELSDVDRLLNAGADKISINS
                     SAIRNPRLVDEIAKNFGSQVCVLAVDAKQTENGWKCYLNGGRIETDKDLFEWTKEAQER
                     GAGEILFTSMNHDGVKAGYANEALAALADQLSIPIIASGGAGCKEHFRDVFLQGKADAA
                     LAASVFHFGEIKIPELKSYLCGEGITIRG"
     CDS             complement(1190..1909)
                     /locus_tag="ctg48_24"
                     /transl_table=11
                     /translation="MIEIIPAIDIIDGKCVRLSQGDYDSKKVYNENPVEVAKEFEANGV
                     RRLHVVDLDGAASHHVVNYRVLEQIAVRTSLVIDFGGGVKSDEDLKIAFESGAQMVTGG
                     SIAVKDPELFCHWLEIYGSEKIILGADVKEHKIAVNGWKDESACELFPFLENYIDKGIR
                     KVICTDISCDGMLSGPSIDLYKEMLAKFPDLYLMASGGVSKMDDIVALDEAGVPGVIFG
                     KALYEGHITLQDLRIFL"
     CDS             complement(1928..2518)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_25"
                     /sec_met_domain="GATase (E-value: 5.9e-24, bitscore: 76.1,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVAVVKYNAGNIRSVDYALKRLGVEAVITADKEELQSADKVIFP
                     GVGEAETTMNHLKATGLDELIKNLRQPVFGICLGMQLMCRHSEEGEVDCLNIFDVDVKR
                     FVPQKHEDKVPHMGWNTIGKTNSKLFEGFTEEEFVYFVHSFYVPTCDFTAATTDYIHPF
                     SAALHKDNFYATQFHPEKSGKTGEKILTNFLNL"
     CDS             complement(2518..3375)
                     /locus_tag="ctg48_26"
                     /transl_table=11
                     /translation="MMTTAKLLLHCPDKPGILAEVTDFITVNKGNIIYLDQYVDHVENI
                     FFMRIEWELKDFLVPQEKIEDYFRTLYGQKYEMDFRLYFSDVKPRMAIFVSKLSHCLFD
                     MLARYTAGEWNVEIPLIISNHPDLQHVAERFGIPFYLFPITKETKEEQERKEMELLAKH
                     KITFIVLARYMQVISEQMINAYPNKIINIHHSFLPAFVGAKPYHAAFQRGVKIIGATSH
                     YVTTELDAGPIIEQDVVRITHKDAIEDLVNKGKDLEKIVLSRAVQKHIERKVLAYKNKT
                     VIFS"
     CDS             complement(4239..4661)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_10"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_27"
                     /sec_met_domain="Acetyltransf_10 (E-value: 2.9e-18,
                     bitscore: 57.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKIKVTDYPRLMEIWESAVLSTHDFLKEEDFLYYKERLPVYFQ
                     YVNLFGFEQEGILIGFMGIAEGNLEMLFIDNKYRGAGIGKKLITYAIDNLQVTKVDVNE
                     QNVQAVGFYKYMGFNIYKRSNLDGEGKEYPILHMQL"
     CDS             complement(4726..5304)
                     /locus_tag="ctg48_28"
                     /transl_table=11
                     /translation="MLLEKLLKEFNFSTNIFNWEEFKLFDQYFERILVSKGTFLIKEGE
                     TERYSYFVFDGILRCWLLNHNGEEQTFWFCKEGTFSMSNISFTLQTRSAFNVQTIVDSV
                     IYRIDKKQVNELYTAIPKVKTVFEDLNAILLNKLLKRNIDLIKYSPEQYYLQMMEEYGI
                     TLNYIPLKDIASYLGITPQALSRIRKRIF"
     CDS             complement(5410..5973)
                     /locus_tag="ctg48_29"
                     /transl_table=11
                     /translation="MKQIIFIFMSLLCFSCSSKAQNQTADTNVQSDKKILVAYFSCTGT
                     TEKAADAIAKTVGGKLYQITPATAYTSADLDWNNKSSRSSIEMTTENSRPELGGEALNL
                     KDYDVIFLGYPIWWNLCPRPVNTFLEKYDFSGKTVIPFATSGGSSITNSVKQLKKLYPK
                     IVWGESRLLNGSVKQAGEWAKGVI"
     CDS             complement(6202..7029)
                     /locus_tag="ctg48_30"
                     /transl_table=11
                     /translation="MNKLLLFSVFSILTLNVMAQEKIVQTAGRDQLGTFAPKFAELNDD
                     VLFGEVWSRTDKLGLRDRSLVTITSLISMGITDNSLVYHLQSAKKNGITRTEIAEIITH
                     IGFYAGWPKAWAAFNLAKGVWSEDIVGEDAKTAFQREMIFPIGEPNTAYAQYFIGNSYL
                     APVSREQVNISNVTFEPRCRNNWHIHRATKGGGQMLIGVAGRGWYQEEGKPAVEILPGT
                     VIHIPANVKHWHGAAADSWFAHLAFEVSGENTSNEWLEPVTDDEYNKLEQTKR"
     CDS             complement(7041..7388)
                     /locus_tag="ctg48_31"
                     /transl_table=11
                     /translation="MCAKLPMAADGIVRLSKIEVYPEYLEEYMKYATEVGEVSLRTEPG
                     VLTMYAVSEKENPGRITILETYASQEAYKSHIASEHFQKYKQGTLHMVKTLVLSDQMPL
                     NPANCINNFIQ"
     CDS             complement(7657..8628)
                     /locus_tag="ctg48_32"
                     /transl_table=11
                     /translation="MQYAPAAVMLGMKVAGVQSRSSWGRMLVSDAFSALLMGGVVNTLK
                     QTTNVERPDGSNKHSFPSGHTATAFMTATMFTKEYGHKSPWVGVGAYSVATATGLMRMA
                     NNKHWLSDVLTGAGIGILSTEVGYYFADLIFREKGINRFANENMFDRMDKPSFVSLYLG
                     LNIPLSGYDINEEMEFRTSSGSSAGVEGAYFFNPYVGVGGRFTVSNTLIIVNEERAENN
                     TFDAISLCGGSYFSYPLSSRWLIGSKLLGGYVHYPQLELTDRSVSSRSGFCMGSGVSLT
                     FKAKEYYGIRFFLDYNLLPSHSRNSGEYMNMLTLGSSFMITF"
     CDS             complement(8680..8838)
                     /locus_tag="ctg48_33"
                     /transl_table=11
                     /translation="MAERGDSLRISTTTNFSRRLDKFSSSRFYQMTYIGVPLIVGGLIV
                     KREDDHF"
     CDS             9014..9376
                     /locus_tag="ctg48_34"
                     /transl_table=11
                     /translation="MSYITTFTGKHFDPIHPVPEKIDMKDIAHALSLICRANGHTRFFY
                     SVAQHSIACCKEAKTRGLSNHIQLGCLLHDSCETYMSNVTRPIKAKLTEYLKFEDHLQN
                     MIWNHFISESLSDTEN"
     CDS             10001..14212
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_35"
                     /sec_met_domain="HGD-D (E-value: 1.5e-22, bitscore: 72.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.1e-33, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVCREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLIAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNNDNHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSDPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVCKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTS
                     FGCGPDAFLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKNFNYFTPFESIFEKAEKAKQVISLGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
     CDS             14217..14837
                     /locus_tag="ctg48_36"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEK"
ORIGIN
        1 acatgaagga agttaccgct ttcttcgcct tttgtccata aacgattctt cgtacggcta
       61 aagaatgtaa cttttccggt ttccaccgtt ttatcataag cttctttatt catgaaaccc
      121 agcatcaaga ccttacgtgt ctcgttgtcc tgtatgatag ccggaacgag tccgttcatt
      181 ttatcgaaat ccaattccat ttttatataa gttctaatta ctattccaat ttacaattac
      241 tacctattcg cctacggaat tcttttgcag acagttccta tatttatctg actatataat
      301 ccatccgcag gaaaacccgg ccggggtgcc tcaccccctg atggtaattc cttcgccgca
      361 aagatacgat tttaattcgg gaattttaat ttctccgaag tgaaaaacac tggcagccaa
      421 tgcagcatct gcctttccct gtaaaaagac atcacggaag tgctccttac agcccgcacc
      481 tcctgaagct atgatgggaa tggagagttg atccgctaaa gcggcaagtg cttcatttgc
      541 ataaccggct tttacaccat cgtgattcat gcttgtgaag agtatttctc ctgctccgcg
      601 ttcctgtgct tctttagtcc actcgaacag atctttatcc gtttcgatgc gtcctccgtt
      661 caggtaacat ttccaaccgt tttcggtctg tttggcatct acagccaaca cacaaacttg
      721 tgagccgaaa ttctttgcta tctcgtcaac caaccgggga ttacggatag cggaagaatt
      781 gatagaaatc ttatctgccc ctgcattcag cagacggtct acatcactta attcattgat
      841 tccaccacct acggtaaatg ggatattgat attagcagca atccgtttta ccaattccgt
      901 aaaagtctta cgtccttcat ggcttgcagt aatgtccagg aaaacaagtt catctgctcc
      961 ctgttcactg taagcacggc ctagctccac cggatcacca gcttgacgca agttgacaaa
     1021 attcgttcct ttcacggttt gtccgtcttt tatatccaaa caaggtacta ttctttttgc
     1081 taacacaatc ctattttatt tattgttcaa caatttataa tctatattcc tgaagctcga
     1141 ttcttatctt ccttataata aaggtatctt atttattccg atacgctcat tatagaaaga
     1201 ttctcaaatc ttgtaaggtg atatgtcctt cgtataatgc cttaccgaaa ataactccgg
     1261 gaacaccggc ctcatccaag gcaacaatat catccatctt gctcaccccg ccactagcca
     1321 tcagataaag gtcagggaat tttgccagca tctctttata caaatcgata gaaggaccac
     1381 tcaacattcc gtcacagcta atatccgtac agattacttt tcgtatacct ttatctatat
     1441 aattttcgag aaatggaaaa agttcacagg cactttcatc tttccaacca ttgacggcta
     1501 tcttatgttc ttttacatct gcccccaaaa taatcttctc actgccgtat atttccagcc
     1561 aatgacagaa taattccgga tctttcactg caatgcttcc tccggttacc atctgcgcac
     1621 cgctctcaaa agcaattttc aaatcttcat cactctttac tcctccacca aaatctatga
     1681 caagagaagt gcgtacagca atctgttcca acacccgata gttaacgaca tgatgagaag
     1741 cagcaccgtc caagtctacc acatggagcc tgcgaacacc gttcgcttca aactcctttg
     1801 caacttccac cgggttctca ttatacacct ttttactatc gtaatctccc tgggaaaggc
     1861 gtacgcactt tccatcaata atatcaatgg ctggaataat ttctatcatc tatttactat
     1921 ttgtatctta gaggtttaaa aagtttgtca gaatcttctc tcctgtctta ccactttttt
     1981 ccggatggaa ctgggtagca taaaagttat ctttatggag cgcagcactg aacgggtgaa
     2041 tatagtcagt tgtagcagca gtaaagtcgc aggtcggcac atagaagcta tgcacaaaat
     2101 agacaaactc ttcttcggtg aacccttcaa acaatttgct attcgttttt ccaatggtgt
     2161 tccatcccat gtgcggcact ttatcctcat gtttctgcgg gacaaaacgt ttcacatcca
     2221 catcaaagat attcaaacaa tcgacttctc cttcttcgga atgccggcac atcaactgca
     2281 tgccgagaca aattccaaat acaggctgac ggagattctt aatcagttcg tccagtcccg
     2341 ttgccttcaa gtggttcatg gtagtttccg cctctcccac tccgggaaaa ataactttat
     2401 cggccgattg gagttcttct ttatcagcag taatcaccgc ttctaccccc aaccgcttta
     2461 aagcataatc cacagaacga atattgccgg cattgtattt tacaactgct actttcatca
     2521 gctaaatatt actgttttat ttttataagc taaaactttg cgctcgatgt gcttctgcac
     2581 tgcacgcgaa agaacgattt tttccaaatc ctttccttta tttacgaggt cttcaatagc
     2641 atctttatga gtaatgcgca ctacatcctg ttcaataatc ggtccggcat ccagctctgt
     2701 cgttacataa tgactagttg caccaataat tttcacccct ctctggaaag ctgcgtgata
     2761 aggcttcgcc cctacaaacg caggaaggaa agaatgatga atattgataa tcttattcgg
     2821 ataagcatta atcatctgtt cggagatcac ctgcatatag cgtgccaata caataaatgt
     2881 aatcttatgt ttggcaagca attccatctc tttgcgctcc tgttcttctt tcgtctcctt
     2941 ggtgataggg aacagataga aaggaattcc gaaacgttct gctacgtgct gcaaatccgg
     3001 atgattactt ataataagag gtatctctac attccactct cctgccgtat accgggctaa
     3061 catatcgaaa agacagtgtg acagcttgga tacgaaaata gccatacgtg gttttacatc
     3121 agagaaataa agacgaaaat ccatttcata tttttgcccg tagagtgttc tgaaataatc
     3181 ttcaattttt tcctgtggaa ccagaaaatc tttcagttcc cattcaatac gcatgaagaa
     3241 gatgttctct acatgatcta catactgatc cagatagata atatttcctt tgtttaccgt
     3301 aataaagtct gtcacttccg ctaggattcc cggtttgtcg ggacagtgca ataacagttt
     3361 ggctgttgtc atcattcttt ctactaatta acgattctag gcagattatt ttctaccttt
     3421 ctaattttag tccgcaaaaa taacgattta ttgcaaaatt acgaattatt caagcagaaa
     3481 gttgatataa aaacggtgat ttcttacaga tagaaagata tcgagagtta ttttcaatga
     3541 aaagaatgac aaactttagg atagtgatgc cattaccttc ggatagtgac ggtattccat
     3601 cgtgatagcg tcactataac gatcagatac cgtcactatc cgaagagaag aaaaacgaat
     3661 attttttttc attacaaaag tactcaaaat gagacactaa gcatttttct tgttttttct
     3721 tgaaaaaaac ttttctcaaa acgcttgcag gtttacaaaa aacaactacc tttgcacccg
     3781 caatcgagag agatgcagat taataaattg aaattctggt gcgttagttc agttggttag
     3841 aatacatgcc tgtcacgcat ggggtcacgg gttcgagtcc cgtacgcacc gcttctttca
     3901 ctaagaagca gagagaaata gaaatgagtt aatccaatta aaatttggtg cgttagttca
     3961 gttggttaga atacatgcct gtcacgcatg gggtcacggg ttcgagtccc gtacgcaccg
     4021 cgaaagcaaa tagtaaatta aagcaaagct ctgaaattca agaaattcag agcttttttc
     4081 tttttcttca gttcatttaa aacagagttt aagtaggcga tagatgtgcc cattcaaact
     4141 ctacaatgat tttttaacca atcattttat tcaaatgtaa cattacatct tcaattaaag
     4201 gtacctatac taagcatctg tttataattg aacagagact acaactgcat gtgtaaaata
     4261 ggatattcct taccttctcc gtccaaattc gaccttttat atatgttaaa acccatatat
     4321 ttataaaaac cgacagcttg aacattttgc tcattcacat caactttagt tacttgcaaa
     4381 ttatctatgg cataagttat taattttttt ccgattcctg cgcctcgata cttattgtca
     4441 ataaataaca tttcaagatt tccttctgca attcccataa atccgattaa gattccctct
     4501 tgttcaaatc cgaatagatt aacatactga aaatataccg gaagtcgttc cttataatat
     4561 aaaaaatctt cctctttaag aaaatcatgt gtactcaata ctgcactttc ccaaatttcc
     4621 atcaaacgtg gataatccgt aactttaatt tttctaatca tacttgtaat tgcaatttaa
     4681 agccgcaaag ttcgttactt atacattcaa aacactgaac ccaagttaaa aaatacgttt
     4741 acggattctg cttagtgctt gcggtgtgat acccaaataa gaagctatat cttttaatgg
     4801 tatatagttt aatgtaatac catattcttc catcatctgt agataatact gttcaggaga
     4861 atatttaatc aagtcgatat ttcttttcaa aagtttattc aacaatatag catttaaatc
     4921 ttcaaataca gtttttactt tagggatagc ggtatatagt tcatttactt gcttcttgtc
     4981 tattcggtaa ataacactat ctacaattgt ttgcacatta aatgcagacc tagtttgtaa
     5041 tgtaaaagat atgtttgaca ttgaaaacgt accctcttta caaaaccaga aagtttgttc
     5101 ttccccgtta tgatttaaaa gccaacaacg taatattcca tcaaaaacga aataactata
     5161 cctctctgtt tctccttcct taatcaaaaa tgtaccttta ctaactaata ttcgttcaaa
     5221 atattggtcg aataacttaa actcctccca attaaaaata ttagtactaa aattaaattc
     5281 tttaagtagt ttttctaaaa gcataatcta aatatgattc gtaatatact tactcattta
     5341 atatattcac tattacttcc gccctattta acttctcata tttagtgaat atattttcag
     5401 tagccatctt tatattactc ctttcgccca ctctccggcc tgcttgacac ttccgttcaa
     5461 caatcggctt tctccccata cgatttttgg ataaagtttc ttgagttgtt ttacactatt
     5521 agttattgag cttcctccgg aagtagcaaa tggaataacg gttttaccgg agaaatcata
     5581 tttctcaagg aatgtattga ccggacgcgg acataaattc caccatatcg ggtaaccaag
     5641 gaatatcacg tcgtaatctt tcagattaag cgcttctccc cccaattccg gacgtgaatt
     5701 ttcagtcgtc atttcaattg aactacggct actcttgttg ttccagtcga gatctgccga
     5761 ggtataggct gtagcgggag ttatctgata aagtttgccg ccaaccgttt ttgcaatggc
     5821 atcggcggct ttttctgtag ttccagtaca agagaaatag gcaaccagga ttttcttatc
     5881 ggactgtaca ttagtatccg ctgtctgatt ctgcgctttt gatgagcagc taaagcaaag
     5941 gagactcata aatatgaata taatctgttt cattttattt tgattttaaa tatttcttat
     6001 cattaattag tttagacatt atcacgatgg agtaacccca caggcgtttt cattcttcca
     6061 ttactttgat aattgcccat atcgtccatc aaacgatgta tttcttctgt attaagcgct
     6121 ttgcgcgtct ttacatattc cttaaaattc ctcggtagtc atattatttc ctttcaaaag
     6181 ataaagcagg attagcaaaa atcatcgttt agtctgttcg agtttgttat actcgtcatc
     6241 tgtgaccggc tcaagccact cattggaagt gttttcaccg gaaacttcga aagccagatg
     6301 agcaaaccaa ctgtcggcag cagctccgtg ccagtgtttc acattggcag gaatatggat
     6361 aaccgtacca ggcagaatct ctaccgccgg tttaccttct tcctgatacc agcctcgacc
     6421 ggctacaccg ataagcatct gtccgccacc tttcgttgca cggtgaatat gccagttatt
     6481 gcggcaacgt ggttcaaaag taacgttaga gatattcacc tgctcgcgcg aaaccggagc
     6541 aagataactg ttaccaataa aatactgtgc ataggctgta ttgggttcac caatagggaa
     6601 aatcatctca cgctggaaag ctgttttggc atcctcacca acaatatctt cagaccatac
     6661 tccttttgcc aaattgaacg ctgcccacgc tttcggccaa cctgcataga aacctatatg
     6721 agtgataatc tctgcgatct ccgtgcgggt gatgccgttc ttcttcgccg actgaagatg
     6781 ataaacgagc gaattgtccg tgattcccat actgataagg gaggtaatgg ttactaaact
     6841 gcggtcacgc agaccgagtt tgtcagtgcg gctccaaact tctccaaaga gaacatcgtc
     6901 attaagttcc gcaaacttag gggcaaacgt tcctaactgg tcgcgtcctg ccgtctgtac
     6961 tatcttttct tgtgccataa cattgagtgt taaaatacta aatactgaaa ataaaaggag
     7021 tttattcata atcatttcgt ttattgaatg aagttattaa tgcaatttgc ggggttaagc
     7081 ggcatttggt cagagagtac gagagtctta accatgtgca gcgttccttg cttgtacttt
     7141 tgaaaatgct ccgatgcaat atgagattta taagcctcct gactcgcgta agtttcaaga
     7201 atagttatcc tgccaggatt ctctttttcg ctgacggcat acatagtcag cactcccggt
     7261 tcagtacgca aggagacttc acccacttcg gtcgcatatt tcatatattc ttcaagatac
     7321 tccggataaa cctcgatttt tgatagccgc acaataccgt cagccgccat aggtaatttg
     7381 gcgcacatac caggctgctg ttttatatcc tttttccctg tcatactgca tgataacata
     7441 acgaataaag acaaaacact tagaattgtt tttatcacca tcttctatct tttcattgtt
     7501 aaacttctga ttgcaaattt actgcgataa aacgaatgga attgtatatc aattacggat
     7561 ttttgtaccc aaatccccga ttctgcaata aagaaccgta cataattcga atgaaatgaa
     7621 ttatattgcc aataaaagaa ttaaatatac tacgatttag aacgtaatca taaatgatga
     7681 ccccaaagta agcatattca tatactcacc actgtttctg ctatgtgacg gaagcaagtt
     7741 ataatcgaga aaaaaacgga ttccataata ttcctttgct ttgaacgtca aggaaacccc
     7801 acttcccatg cagaaaccac ttcttgaaga aaccgaccgg tcagttaatt ccaattgtgg
     7861 ataatgcacg tatccaccca gaagtttact gcctatcagc catcgtgaag acaacggata
     7921 tgaaaaatag cttcctccgc aaagcgatat cgcatcaaag gtgttattct ctgcccgttc
     7981 ttcattgaca ataatcaaag tattggaaac tgtgaatcgt cctccaacgc ctacatacgg
     8041 attaaaaaaa taggccccct ccacaccggc cgaactgcct gatgaagtac ggaactccat
     8101 ttcttcgttg atatcataac cactcaacgg aatattcaac ccgagataca aactgacaaa
     8161 tgaaggcttg tccatcctgt cgaacatatt ttcattcgca aacctattga tccctttttc
     8221 cctgaatatc agatcagcaa agtaataccc cacttccgtt gacaatattc cgattcctgc
     8281 acccgtcaat acatcactta accaatgctt gttgtttgcc atccgcataa gaccggttgc
     8341 agtagccaca ctatatgctc cgacacctac ccacggactt ttatgtccgt attccttagt
     8401 aaacatggta gcagtcataa atgccgtagc cgtatgtccg gatggaaaag agtgtttgtt
     8461 tgagccatcc ggacgctcga cattcgtcgt ttgcttcaaa gtatttacca caccacccat
     8521 cagcagtgca gaaaaagcgt cggaaacgag cattctaccc catgaactgc gactttgtac
     8581 tccagctact ttcataccaa gcatcaccgc agcaggggca tattgcatat aatcatccaa
     8641 atgacgattg aaacggggca gatattcgtt acgtaaacct caaaaatgat cgtcctccct
     8701 ttttacaatc aagccaccaa caattaacgg aacgccgata tacgtcatct gatagaaacg
     8761 ggaagatgag aatttatcaa gccttctact aaaattggtt gttgtagaga tacgcaaact
     8821 atcccctctt tctgccatta cattatctgc cgaattttga gccgataaga aagaaaagct
     8881 acaaatgcca acaatgcata ttacaatcct tttcatgcta tcgtaatttc ttttgaatta
     8941 ggatacaaag ataacaggca actttgtaga aagtttgaag atttacaaaa atatgactat
     9001 aaattctata gttatgagtt acattacaac ttttacgggg aagcatttcg accccatcca
     9061 tcctgttcct gaaaaaattg atatgaaaga catcgctcat gccttgtctt tgatctgtcg
     9121 tgcaaacggt catacccgtt tcttttattc tgttgcccaa cattctatcg cgtgctgcaa
     9181 agaggctaaa acacgaggac tttccaacca tatacagttg ggatgtttgt tgcatgacag
     9241 ctgtgaaact tatatgtcaa atgtgacacg tccgataaaa gccaaactta cagaatatct
     9301 caaattcgaa gatcacctgc aaaatatgat ttggaatcat tttattagcg aatccctctc
     9361 ggatacagaa aactaaatgg cacgcggact ctatttttaa aaccgataag atacttttct
     9421 catcagactc ttgacaaagg actttttatg ttgtatcttt gagaaaagaa aaagtataag
     9481 caacatgaaa atagtaagaa ataatcatac ataaatcata aataacctgg tattttacaa
     9541 taccactcct atacgatatg gggcaatagt cgaatgatta ttgccccatt ttgtttataa
     9601 ttcagcttaa aatctctcgt ctgattctaa aactgttcta caatagttta taataaactc
     9661 gaataccgtt ttactaaaac tatcaaaaag tttattataa acagaatccg ggtttattaa
     9721 aagccacgtt tccttttgtc aaaaatagag taaacaagat ttctaagatt caccataaaa
     9781 gatctgctac aaccttacaa gtaatataag catacaatca ttcatttact tctttattta
     9841 cacaatcgtt ttcctccctc acattccatc tttctttttt cccaattcgt taattaaacc
     9901 caaaacttca attacgattt gccgtatcta ccatattttt acatacattt gcgtctgaca
     9961 cagatgtcaa acacgaggtc taatttaaga tatttggtat atgaatgtat ataaagtggg
    10021 tttagatata ggctctacta ccactaagat ggtagtattg gataaagatg gaactacagt
    10081 cttgttttcc ggatacaaaa ggcatcaggc aaaaatacaa gaatgtttac tcggatttct
    10141 ttatcaaata aaggaacagt tgggtgatat tcctttatct ttccacatta cgggctctgt
    10201 tggaatggga atttcagaga aatgctctct gccgtttgtg caagaggttg tagctgcaac
    10261 aaactatgtg tgccgggagc atccgcacac agccactatg atcgatattg gaggagaaga
    10321 tgcgaaagtt gttttctttc aggacggaca ggctacagac ctgcgcatga atggaaattg
    10381 cgccggcgga accggggctt tcattgacca gatggctatt ctgcttggag tctccatcga
    10441 cgaattgaat gaactagcac ttcgttccaa tcaggtatac tctatcgctt cacgctgcgg
    10501 agtattctgc aaaacggaca tacagaatct gatagccaaa aatatatcta aagaaaatat
    10561 agcagcttcc attttccatg cagtagccgt acagaccact gtcacacttg cacgcggttg
    10621 caatatcgta gctccggtat tactctgcgg tggcccattg acttttattc cggcccttcg
    10681 aaaagcattt gccaactatc tgaatctgtc acaagataca gatttcatat taccggaaaa
    10741 aggaaatctg atccctgcct ggggagcagc attggcagag aacaatgaag aaagtattca
    10801 tctctccaac ctgatacagg taatagaaaa caaactaagt gttacctcac ctttccagag
    10861 tgatctttct cctatattcg acagtgagga agaatatcgg tcatggaaaa aagaaaaaga
    10921 ccagtataaa attcaatatg ccagtctgcg tcccggatta caggaagcaa ctatcggcat
    10981 agactccggc tctactacca ccaaaatcgt agtactcgac aacaatcatc gtatccttta
    11041 ctcctattat cacgacaaca acggaaaccc tataaaaaca gtagagaacg gcttgcagaa
    11101 actatatgaa gaatgccgga gacgaggaac taccctgcgc ataaaaggag gatgttctac
    11161 cggttacgga gaagatctga taaaagcggc tttccacatg gatgcgggaa tcattgaaac
    11221 catcgctcat tatgctgctg ccaaacatat cagcaaagaa gtttctttta tcctggatat
    11281 tggagggcag gatatgaaag ccatctttgt gaacgacgga gtaatcaaca gaatcgaaat
    11341 caatgaagcc tgttcctccg gttgcggttc ttttatcagc acatttgcgc aatcgctgga
    11401 ttacagtgtg gaggactttg ccaaagcagc ttgtttttcg caagcaccat gtgatctggg
    11461 tacacgttgc acagtcttca tgaactccaa agtaaaacag gtacttcggg aaggagcgtc
    11521 cgtagcggat atagctgccg gattatctta ttccgttgtt aaaaactgcc tgtataaggt
    11581 tctgcaatta aaagacacgg agatacttgg cgaccatatt gtcgtgcagg gaggaaccat
    11641 gcgtaatgat tccatcgtac gaagtctgga aaagctgacc gggaaacaaa ccttccgcag
    11701 taactgtcct gaattgatgg gtgctcttgg ttgtgcccta tatgccaaac aaatcgaaaa
    11761 tgcccgggtg acggagctga acgagatgct ccaatgggcg caatatactt ccaagcaact
    11821 tcaatgccgg gggtgcgaga accagtgcgc cattatgcga tatacgttca acaatgacaa
    11881 ccattacttc tccggcaacc gatgtgaaaa ggtattttcc aataaaggaa gccatgcgga
    11941 caaaggcatc aatacgtatg ataaaaagct ggaattatta ttcgaccgga gcgcagacat
    12001 tccacaaccc ctatttacca taggcattcc acgtattctg aatatgtatg aggaataccc
    12061 tttctggcat accttattta ctgcttgcgg cattcaggta cagttgtcgg acccctctac
    12121 attcagcaaa tacgagactg ctgccggcat ggtgatgtct gataacatct gcttccctgc
    12181 caaacttgtg cacagtcata tccgtaacct gacactgcaa aacgtcaacc ggatatttat
    12241 gccgttcgtt gttttcgaga aaaaggataa gcaacagcaa aacagctata attgccccat
    12301 cgtttccggt tattcggaag tcatcaaaag tgtacaggaa gagaatatac cgatagatgc
    12361 tccgactatc accttcaaag atgaagcatt gctgtataaa caatgctatg aatatctgaa
    12421 atctttgggt atcagggatg aggtatgcaa aaatgccttc tcacgcgcat tacaggaaca
    12481 atatgctttc gaagaaaaaa ttgctgccta taatcaggaa gttctgaacg agggacggga
    12541 aaaacacaaa ctgattatct tactcgccgg acgcccttac catagcgatc cactgataca
    12601 gcacaaggtt tcggacatga ttgctgcgat gggagtttat gtgataactg atgatattgt
    12661 ccgccagcag gagatttcat tggaaaagac tcattacctc tctcaatggg catttaccaa
    12721 ccgtattctg aaagcaacca agtgggcggc aatgcaagag ggtgacatac aatatatgca
    12781 gatgacttct tttggctgcg gtccggatgc tttccttata gatgaagtac gtaacttgct
    12841 gaaacgatac ggcaagaatc ttactttgct caagatagac gatgttaata atatcggctc
    12901 catcaaatta cgagtccgct cgttggtgga aagcttgaat ttcagtttga aacattctca
    12961 agcgaaagat cccgagccat ttgtttcaac tgctcctttc accaagaaag acaaaaagaa
    13021 gaaaatcctc gctccattct ttacgccttt catttcacca ctcattccat ccatcatgaa
    13081 agtggccgga tatgaaatgg aaacgttacc gttgagcgac accgcatctt gcgactgggg
    13141 attgaaatac tccaataatg aggtatgtta tccggcaaca ttgattgtcg gcgacatagt
    13201 aaaagccttt aaaagcggac gttatgatcc tgccaatacg tgcgttgcca tcacacaaac
    13261 cggtggacaa tgtcgtgcca gcaactatat ttcactgata aaaaaggcat tgattgagaa
    13321 tggatacacc aatacaccgg tggtatcact tgctttcggc agtggtattg aaaatgagca
    13381 atccggtttt aaagtaaact ggctcaaggt tttgccaatc atacttgcgt ctgtgttata
    13441 cagtgattgt atcgctaaat tctattatgc agccgtcgtt cgtgagaaag aacggggaca
    13501 ggccgcccgt ctgcgcgatc tttatctgga tacagcacag cccatcatcc agaaaaataa
    13561 accggaggac ttgttgagtt acttatatct cgctgccaga gacttcaaca aaatctgtga
    13621 acagagatcc tgtcacaaag taggtattgt tggagaaata ttcctgaagt tcaacccttt
    13681 tgctcaaaag gacgtcacct catggctcat caaccagaag atcgaagtga ttccgccact
    13741 gataagtgat ttcttcatgc agggatttgt caacctgaaa gtgagacaga accaacactt
    13801 gcagcgaaaa ctcactcccg actttgttat cgactggtta tacaagaaag tccagaagca
    13861 gattaataaa gtgaatgaaa tcggcaaaaa tttcaattac ttcacgccgt tcgaatcaat
    13921 ctttgaaaag gcagaaaaag ctaaacaagt catctccctg ggcacccagt ttggagaggg
    13981 ttggctgata tccggtgaaa tactatcctt tgcttcccaa ggagtcaatc atgtcattag
    14041 cttgcaacct ttcggatgca ttgccaatca cattgtagaa aaaggaatag aaaaacgtat
    14101 aaaatcgctg tgccctcaaa tgaatatact atctttagac tttgacagta gcgtcagcga
    14161 tgtgaacata acaaacagat tattactttt tattgacaac ataaacaact aaaattatgg
    14221 ctacaacgga acatagcgat ttagagcagc aaataataaa aactgcccaa caacttttta
    14281 tagaaaaagg atttgtggag accagcatga gtgatattgc tgcaacggta ggaatcaacc
    14341 ggcccacttt acattattat ttcagaacca aagataagat gttcaaagcc gtgttcggct
    14401 cgatagtcat gtctttaatg ccgaaaatac aggatatagt aaaacaggat atcccattta
    14461 tggagcgact aagcatgatt ctggatgagt atattgagct tttcacaagt aatccctgtc
    14521 ttcccagatt catttgcgga gaaatacagc gtgatgtaaa ccacttgctt gccactgcaa
    14581 aagaacttca gttcggagat gctttatccc aagtgaaaga cagtatactg acagcaatgg
    14641 aagacggtaa acttaaaaag gttccgatac atattgtatt tctgactgtc tacagcctat
    14701 tgagctatcc atttcttgcc aagaacctga tagtatcttt attcttggaa gatgaagccg
    14761 cttttgctga cttcctgcaa gaatggaaac aaaacatcat caaccaattg cagaacttat
    14821 tgtgttatga gaaatagtat agacactata aacaaaaaga gactgaatat tcagtct
//
