LOCUS       gnlProkkaJPPCAGAM_87   10493 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPPCAGAM_87.
ACCESSION   gnlProkkaJPPCAGAM_87
VERSION     gnlProkkaJPPCAGAM_87
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 07:59:22
            Original ID  :: gnl|Prokka|JPPCAGAM_87
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10493
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10493
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1188:8973]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1189..8973
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10493
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10493
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             147..671
                     /locus_tag="ctg87_1"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             675..1157
                     /locus_tag="ctg87_2"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWKDKELSEDKKEAINNLRNLEENPYPYSEME"
     CDS             1189..2082
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 268.8; E-value:
                     9.4e-82)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 9.9e-14, bitscore:
                     41.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLYPITKGVSKQLLPIFDKPMIYYPISVLMLAG
                     IREILIISTPYDLPGFQRLLGDGSDFGVHFEYAEQPSPDGLAQAFIIGEKFIGSDSVCL
                     VLGDNIFYGQGFTRMLREAVHSAESENKATVFGYWVSDPERYGVAEFDQEGNVLSIEEK
                     PQIPKSHYAVVGLYFYPNKVVEIAQNIKPSPRGELEITTVNQQFLLDQELKVKLLGRGF
                     AWLDTGTHDSLSEASTFIEVIEKRQGLKVACLEGIAFRQGWISSEKMKVLAQPMLKSQY
                     GQYMLKMIDITTSNEE"
     CDS             2255..3559
                     /locus_tag="ctg87_4"
                     /transl_table=11
                     /translation="MIYMFTRMIRSLLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTA
                     AIYEGEILWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVAL
                     LGFALLPVPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKT
                     LGQFVMDNLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKD
                     RRKFLRQFFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFV
                     LVLMFLIVFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMG
                     YIPFTYLIERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRT
                     ALFSGFVSVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             3573..4271
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_5"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.3e-14, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             4291..5592
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_6"
                     /sec_met_domain="CTP_transf_like (E-value: 2.8e-13,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1e-122, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 5.1e-65, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             5604..6740
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_7"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.7e-22, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.5e-21, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             6737..7861
                     /NRPS_PKS="Domain: Aminotran_5 (30-301). E-value: 1.1e-33.
                     Score: 108.4. Matches aSDomain:
                     nrpspksdomains_ctg87_8_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.9; E-value:
                     1.5e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_8"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-31, bitscore:
                     99.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIVGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAISFLKISFKNIV"
     aSDomain        6827..7639
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg87_8_Aminotran_5.1"
                     /evalue="1.10E-33"
                     /label="ctg87_8_Aminotran_5.1"
                     /locus_tag="ctg87_8"
                     /protein_end="301"
                     /protein_start="30"
                     /score="108.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIVGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIKREWQSGLV"
     CDS             7864..8973
                     /NRPS_PKS="Domain: Aminotran_1_2 (37-163). E-value:
                     1.2e-06. Score: 19.8. Matches aSDomain:
                     nrpspksdomains_ctg87_9_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     280.3; E-value: 4.2e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_9"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.3e-95,
                     bitscore: 310.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.3e-07, bitscore:
                     19.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEENQITVTSPLLPSLDDFLPYLEDIWKRKWITNNGYYHQELEKA
                     LCQYLKVPYISLFTNGTLPLICSLQALRITGEVITTPYSFVATTHALWWNGIKPVFVDI
                     DPKTCNIDPNKIEAAITPKTTAIMPVHVYGNPCDFIAIQDIADKYGLKVIYDAAHAFGV
                     EVDGKSLLEFGDMSTLSFHATKVYNTIEGGALVCHDRQIKERVDFLKNFGFAGETQIVA
                     PGINGKIDEIRSAYGLLNLKAVDSAIEYRHQISKRYREGLGGIDGISYMPEMHNIRHNY
                     SYFPIFIDSVKYGITRDELYEKMKRNGVCGRRYFYPLITNFSTYCGLDSAQISNLPVAN
                     RIANSVICLPLHTGLTSIDVERIIELLKK"
     aSDomain        7975..8352
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg87_9_Aminotran_1_2.1"
                     /evalue="1.20E-06"
                     /label="ctg87_9_Aminotran_1_2.1"
                     /locus_tag="ctg87_9"
                     /protein_end="163"
                     /protein_start="37"
                     /score="19.8"
                     /tool="antismash"
                     /translation="YHQELEKALCQYLKVPYISLFTNGTLPLICSLQALRITGEVITTP
                     YSFVATTHALWWNGIKPVFVDIDPKTCNIDPNKIEAAITPKTTAIMPVHVYGNPCDFIA
                     IQDIADKYGLKVIYDAAHAFGV"
     CDS             8970..9518
                     /locus_tag="ctg87_10"
                     /transl_table=11
                     /translation="MTSFYSEKELANIGLAVYGTNVLISRKVSFYSPKNIYIGNNVRID
                     DFCILSGKILIGSNIHISAYVAIYGGYGVVLEDYVGISPRTTIYSAMDDFSGDYLVGPI
                     HDKRLTHVIGGEVRICKFAHIGANTIVYPGCSIGEGTVVGAMSMVRKSLDAWGVYIGIP
                     AKFLKNRNKNMQSLIYGKE"
     CDS             9505..10449
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.1e-22,
                     bitscore: 67.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKNNRIPLVSVCCMTYNHDKFISQCLDGIIQQKGNFSIEILIHD
                     DASSDHTRQIIEFYRDKYPDIIKPLYQEINQYSRGVNIWNTYMFPLVKGEYIAICDGDD
                     YWIDQYKLEKQITFLQKYADYNLVYTNKIVINELGTRVIRNHPKYLSGNLFVNLLSGGN
                     PITTSTVCIRTHDAFEIMDIVNSIPFRTVMGDLQLWLALAIKGKFKYLAFKSTVYRLSS
                     ISLSHSLSVNREIRFSKHEYFIKKYFVDIFQVNIDKNILERTYYKNTIRRLFSFRKEIF
                     LSYVFKSVKKDPFLIFDIKIITLVGVKLLKSIL"
ORIGIN
        1 acgaacgttt tttgaaacac attcgttcgt tctcaacttc taaaaatgtt tcgtaaaatt
       61 tgacggtttg aaagagaaaa gatgtctcgt tcaaaccgcg aagcgcaccc gaaacaaagg
      121 aaaatttccc caagtataaa tcgtaaatgt ctgaacaaca gaagtattgg tttgccgccc
      181 gtacccgaga taaacaagag tttgctattc gtgactctct tgaaaaattg aagactgaac
      241 ttgatctcaa ttactatctt cccactcagt ttgtcatccg gcagttgaaa tatcgtcgaa
      301 aacgggtgga agtccctgtt attaagaatc ttatcttcat ccaagctacc aagcaagatg
      361 cttgtgatat ttctaataaa tacaatatcc agctttttta tatgaaagac ctgcttacca
      421 gggccatgct gatagttcct gataaacaga tgcaggactt catatttgtc atggatttag
      481 atccgaatgg cgtcagtttc gataatgacc atttatctgt tggtagcagg gttcaggtag
      541 ttaaaggtga tttctgtggt gtcgagggcg aacttgccag cgaggccaac aaaacttatg
      601 ttgttattcg tattgccggt gtattgagcg ccagcgtcaa agttcctaaa agttatttac
      661 gtgtcattta agttatgaat acactcactt ctcaaattga acaattacag agtctcgcgc
      721 acgagttact ctatttaggt gtggatggtg ctcctattta taccgatcat ttccgtcagt
      781 tgaacaaaga agttttagaa caatccgatg cgttgtatcc tcagcgtggt gctactcccg
      841 aagaggaagc aaacatctgt ctggcattat tgatgggtta caatgcaacc atctataatc
      901 agggtgacaa ggaggagaaa aagcaagttg ttctcaatcg ttgttgggac gtgcttgacc
      961 aacttcctgc tactttattg aaatgccagt tgttgactta ttgttatggt gaggtgtttg
     1021 aagaggagtt ggcgaaagag gcgcatacta tcatagaaag ttggaaagat aaagaacttt
     1081 ctgaagataa aaaagaggca atcaataatt tgagaaattt ggaagagaat ccatatcctt
     1141 atagtgaaat ggaatagaat aattctattt tttttattta tttgacttat gaaaggcatt
     1201 gttttagctg ggggatctgg tacacgttta tatcctatta ctaaaggagt aagcaaacaa
     1261 cttcttccaa ttttcgataa acccatgatt tattacccca tctctgtact tatgttagct
     1321 gggatacgag aaatactaat tatctctact ccttatgact taccgggttt tcaacgttta
     1381 ctgggcgatg gttctgattt tggagtacac tttgagtatg cagagcagcc ttctcctgat
     1441 ggtttagcac aagcatttat tattggagag aagtttattg gaagtgattc tgtttgttta
     1501 gttttaggag ataatatttt ttatgggcaa ggttttacgc gcatgttgcg tgaagcggtt
     1561 cattctgctg aatcagaaaa caaagcaacc gtttttggtt attgggtaag tgatcctgaa
     1621 cgttatggcg ttgcagagtt tgatcaggag ggaaatgtac tcagtattga agaaaagcct
     1681 caaataccta aatcacatta tgctgttgta ggactttatt tctatcctaa taaagtggtg
     1741 gagatagccc aaaatatcaa accttcccct cgtggagaat tagaaataac tactgttaat
     1801 caacagtttt tgttagatca ggaactgaag gtcaaattat tagggcgtgg ctttgcttgg
     1861 ttggatacag gtacgcatga ctctctgtcc gaagcgagca cttttatcga agtgatagaa
     1921 aaacgtcaag ggctgaaagt tgcttgttta gagggaattg cttttaggca aggttggatt
     1981 tcttccgaga agatgaaagt attggcacaa ccgatgttaa agagccaata tgggcaatat
     2041 atgttgaaga tgattgatat aacgacctct aatgaggaat agatgcctga attagatagt
     2101 aaaaaaatta ataatactga cttcttcaaa tatagctaat ccttataatt ctttatttat
     2161 ggataaatag atttctgagt gttttttatt tagcgaatag aatattttta cattcagccc
     2221 tgttaaatcg taatttgaat tgtcgttaca ttggatgatt tatatgttta cacgaatgat
     2281 tcgttccctt ctttcccgtt ctccccttta cgttttggct ctctatgcca gcgttttgat
     2341 ttttctggtt tatacctgtg cctatgccta ccgtaagcca tttaccgcag ccatttatga
     2401 aggtgagatt ctttggggat tcgatgtcaa aatcctgtat gtcctttctg agattatcgg
     2461 ctacgccctt tccaagttca tcggtgttcg tattctgcct tcgatgaaag cgggtcaccg
     2521 catctattat ataatagggc tgcttacttt ttccgaagtt gctttgttgg gttttgcact
     2581 tcttccggtt cctttgaagg tgtgttctat ttttctgagc ggtcttcccc tgggtatgat
     2641 ctggggtgtc atttttagct atatcgaagg gcgtcgtatc agtgaaatat tgaatgtcgg
     2701 gctgagcgtt gctttgatag tctcttccgg tttggtgaaa accttgggac aattcgtgat
     2761 ggataatttg catgtgtcgg aatattggat gccttttacc accggtttgt tggtataccc
     2821 tgttatgttg ctttgcagct ggcttctcaa tcagattccg gctcccaatg agcaagatat
     2881 catacagcgt accaaacgtg ctccgatgga tggtaaagac aggcgtaagt ttttgaggca
     2941 attcttttgg ggaatctgca tgctggttgt tttttacggt gccctgaccg tgttccgtga
     3001 gcttcgtgac tctttcgctg ccgatatttg gaaggagctc catattgagg gtgcaatgat
     3061 ctttactcag acagaggttc ccattgccgt ttttgtcctt gtactgatgt tcctgattgt
     3121 gtttgtccgt aataatcgtt tggctcttaa tatcatttat tgcatcgccg tcacaggcgg
     3181 ttccttaatg gttttttcca cattgcttta tgtgtacggt tttctttctc ctatttggtg
     3241 gatgattctt tccggtcttg gtctgtatat ggggtatatt cctttcactt acctgataga
     3301 acgtctgatt gcttccctta gggtggttag tacggctgtt tttattattt atttggccga
     3361 ttctttcggc tatctgggca ctacgggtgt gtttatggtc aagaacttcg tttctgctga
     3421 catttcctgg actgtcatgc tgatgcgtac tgcccttttt tcaggatttg tttctgtcct
     3481 gtcgattttt gcgatttact gttatttcaa gcaacaattg aattcactta tattaattcc
     3541 ctctgaaatt catgattaaa acagcaatga tcatggctgc cggtcttggt acccgcttcg
     3601 ggcattatac cgagcttgtg cccaaaggtt ttgtggaggt tggtggaaaa cctatgatta
     3661 tccgctctat cgaaaccctt ctttcctgcg gtatcgaacg tatcatcctc ggtacgggtt
     3721 ataaaaaaga ggcttatgaa gcccttcagg cggatttccc ccagatagag acctgtttca
     3781 gtccccgtta tgccgatact aacagtatgt acactctgta caatacgcgt gacgtgatag
     3841 gcgatgacag tttcctgctg cttgaatcgg accttgtttt tgaacgcaag gccatccttt
     3901 cgctactgga tgacgaattc ccggatgtga tgcttgtctc ttctctgacc aagttccaag
     3961 atcagtatta tgtggaatat gaccgcaatc acatccttac ttcctgttcg gtagacaaga
     4021 acgcccttga ggcaaaaggc gagctggtcg gtatccataa actttccaat actttctacc
     4081 gccggatgtg cgccgattat gcgaccatcc tggagtccca gcctaaactg ggttacgagt
     4141 acgaactgct ccgcatgtcc cgttccgttt cccctgtccg tgtgctcagg gtggaggggc
     4201 ttaaatggta tgaaatcgat gatgaagccg acctttcgta tgctgaggag cacatcatcc
     4261 gctattgtta aaaacaaatc ttttccatat atgaacaaga aaatctatgt cggtatgacc
     4321 gcggatatca tgcatccggg gctgatccat attattcatg aagctactaa atacggtgat
     4381 gtcatcgtcg gtctgctgac ggacaaggcc atcgccgaac acaaacgcct cccttacctt
     4441 acctatgatc agcgtaagga ggttgttgag aatatcaaag gggtttgcga agttgttccc
     4501 caggaggatt ggagctatgt tccgaatctg gaaaaactca agcctgacta tatcatccac
     4561 ggtgacgact ggaaaacggg tccgttgcgc gaggtgcgcg aacaggtttt tgaggtgatg
     4621 aacgcccagg ggggcaaggt aatcgagatc ccttataccc ggggcatcaa ctcctcctcg
     4681 ctcgacaagg atatcaaggc gatcgggact acccctgacg tacgtcttaa gtccctccgc
     4741 cgcctgatcc aggccaagcc tgtggtccgt atcctggagg ctcacgacgg tctttgcggt
     4801 ctgattattg agaatcttga agtccagaag ggtgataagc gcgaggtctt tgacggcatg
     4861 tggtccagca gcctgaccga ctccacgagt aagggtaaac cggatattga agcggtcgac
     4921 cttaccaccc gtttacagga cctgaacaat atccttgaat gtaccaccaa gcctattatt
     4981 tttgatggag acacgggtgg caagatcgaa cactttgtct ttactgtgcg cactctggaa
     5041 cgtcatggca tttctgcggt aatcattgaa gataaagtcg gtctgaagaa gaattccctt
     5101 tttggtactg acgctatcca gactcaggat agtatcgagg gtttctgcga taagatcaga
     5161 gcagggaaga atgcccaggt caccggtgac tttatgatca ttgcgcgtat cgaaagcctt
     5221 attgccggca aacccatgag tgacgccctc gaacgtgctt atgcctatgt acaggcgggt
     5281 gcggacggca tcatgatcca cagcaaggat aagtcgggtg aggatatccg tgagttctgc
     5341 cggactttcc gcaaagaata cgcccatgtt cccattgtcg ttgttccgac gacttatgac
     5401 catgtgcacg aatccgaact tcacgaatgg ggtgccaacg tagtcattta cgccaaccac
     5461 cttctccgtg ccgcttaccc ggccatgatg aacgtggcca ggaccatcct tgaaaacgag
     5521 cgcgccgagg aggtccgtcc gctttgtatg cctatcaagg aaattctgga attgattccg
     5581 ggcactaaat aaatcagacg gttatggtaa gtgtagaaaa gatatacgat acgttccttc
     5641 atcacggtgt tgacttcttt acgggtgttc ccgattccct tttgaagaat atttgcgcct
     5701 atatcacgga tcatgctccg cgtggtaagc atatcatcgc cgccaatgaa ggttccgcgg
     5761 tgggcattgc ctgcggttat tatatggctt ccggcaacgt tcctttggtt tatatgcaga
     5821 actccggtct gggaaatacg gtgaatcccc tcttgtccct tgcggacgag aaagtgtaca
     5881 gccttcctct tcttttgctg gtcggctggc gcggtgagcc cggcacgaaa gacgaacccc
     5941 agcataagaa gcagggcgag gttacccttg atcttctgaa agccatgaaa attcctttta
     6001 taattctgga tacggatgaa gacgaggccc tggcgcagat ccatgatgcg gttgtctcgg
     6061 cgaagagccg gtcgattccc catgcgattg tcatccgtaa agatacgttt ggaaaatata
     6121 aattgcgtca ggaagccttg aatgactatc ctctgtcccg tgaggaggcg ctaatgcagg
     6181 ttgtcgacca cctcggggac aatgacattg tggtttccac cacgggcaag ctctcccgtg
     6241 agcttttcga gtaccgtgaa tcgaaagggc aggggcacgc aagggatttc ctaactgtgg
     6301 gttccatggg tcacagttct tccattgccc tggggattgc ccttgagaag cctgaccgcc
     6361 gtgtctactg tcttgacggt gacggtgcct ttatcatgca catgggtgct gtcagcaata
     6421 tcggcgatct ttctcccaag aattacaggc acgtcctttt caacaacggt gcccatgaat
     6481 ctgtcggcgg tcaacccacg ctcggtttcc gtctggatat cgcctcgata gcgaaaggtt
     6541 gcggttatgc gcatgtactg actgcctccg acaaggaagg gctttcgtgt gcgcttgaga
     6601 agctgtccgg cctgtccggc ccggttcttc ttgaaattaa ggtccggatc gattcacgtg
     6661 atgatctggg tcgccctacg actactccgg tagagaataa agagcatttt atggcatttt
     6721 taaaagatac gcattcatga atatcgaaag aaagatcctt ttgaatccgg gtcccgccac
     6781 cacgacggat acggtgaagc tggcgcaggt tgttcccgat atctgtccgc gtgagaaaga
     6841 gtttgcgggt atgatgaaac agttacgtga cgacctggtc cgcgttgcgc atggagacct
     6901 ctccaaacat acggccgtcc tgttttgcgg ctcgggtacg atcaatatcg atatctgcct
     6961 gaactctctt cttcctgcgg ataagaaagt tctggttgtc aataacggtg cctacagcac
     7021 ccgtgcggtg gaagtctgcg aatattacgg tcttccccat atcgatttga agttttccgt
     7081 ttacgaactt cccgacctgt cggtaatcga aaagacgctt tccgacaatc cggacatcgc
     7141 tttggtctat accacgcacc atgaaacggg tacgggtatc ttgaacccca tccgtgagat
     7201 cggaaaaata gcccattcgc acggtgccgt ttttgttgtc gacaccactt cttccctggg
     7261 tatgattcct tttgatatcg ggaaggataa tgttgacttt tgtatggctt cggctcagaa
     7321 aggccttcag gccatgacgg gtctttcctt tatcgtaggt gatgaatccc tgatacgtgc
     7381 ttcaagggat tatccgaaac gttcctacta ttgtaacctc tatttacaat acgattactt
     7441 tgagaagacg ggtgagatgc attttactcc tcctgttcaa accgtttacg ctgcccgtca
     7501 ggctcttgat gaatattttg cagtaggtga agaggctaaa ttcgcccgtc acaagagggt
     7561 ctttgaagcc atccataaag gtttgcaaga gcttggtctt cagtatgcga tcaaacgtga
     7621 atggcagtcg ggtcttgttg tttctgtatt gtatcctgat gatcccctct gggattttga
     7681 taaggttcat gattactgct atgaacgtgg ctttacgatc tacccgggta agatttccac
     7741 aacgaataca ttccggcttt gtgcgttggg agagattgat gtggaggata ttgagaggtt
     7801 ctttgaggtg atgagggaag caatttcatt tctcaaaatc agttttaaaa atatagttta
     7861 attatggaag agaatcaaat aactgtaact tcgcctttat tgccttcttt agacgatttt
     7921 ttaccatatt tagaggatat atggaagcgt aaatggatta ccaataatgg gtattatcat
     7981 caagaattgg agaaagcttt gtgccaatac ttgaaagtac catacatctc tttgtttaca
     8041 aatggtactt tgcctttaat ttgctcttta caagctttga gaattactgg tgaagttata
     8101 acaacaccat acagctttgt agcaacaacg catgctttat ggtggaatgg cattaagcct
     8161 gtgtttgtgg atattgatcc taaaacttgc aatattgatc cgaataagat tgaagcagct
     8221 attactccta agacgacagc tattatgcca gttcatgtct atggaaatcc ttgcgatttt
     8281 attgctatcc aggatattgc agataaatat ggactaaaag ttatttatga tgcggctcat
     8341 gcttttggag tagaggtaga tggaaaatct cttctagagt ttggagatat gtccacacta
     8401 agttttcatg caactaaggt ttataataca attgaggggg gagcattagt ttgtcatgac
     8461 cggcagatta aagagagagt tgattttttg aagaattttg gttttgctgg tgaaactcaa
     8521 attgtggctc ctggaatcaa tgggaaaata gacgagattc gttctgcata cggactactt
     8581 aatttaaaag ctgttgattc tgctattgaa taccgacatc aaatatctaa aagatatcgt
     8641 gagggattag gaggtattga tggtattagt tatatgcctg aaatgcataa tatacgtcat
     8701 aattattctt attttcctat ctttatagat tctgtaaagt atggtattac tcgtgatgaa
     8761 ctttatgaaa aaatgaaacg aaatggtgtg tgtggtcgga gatattttta tccattaata
     8821 acaaactttt caacgtactg tgggcttgat tccgctcaaa taagtaatct tcctgttgca
     8881 aatagaatag ctaactctgt catttgtctg ccattacata ctggcttaac ttctattgat
     8941 gttgaacgta taattgaact tttaaaaaaa tgacatcttt ttattcagaa aaagaattgg
     9001 caaatatagg tttagcagta tacggcacaa atgttctgat ttctaggaaa gtctcttttt
     9061 attctcccaa gaatatatat ataggaaata atgtacggat agacgatttt tgtatattgt
     9121 ctggcaaaat tctcatcggt tccaatatac atatatctgc ttatgtagct atatatggag
     9181 gatatggagt ggttttagag gattatgtgg gtatatctcc tagaacaacg atttatagtg
     9241 caatggatga ttttagtggt gattatttag taggtcctat tcatgataaa agattaactc
     9301 atgttattgg tggagaagtt cgaatttgta agtttgctca tattggcgca aatactattg
     9361 tatatcccgg atgttctatt ggtgaaggaa ctgtagttgg agcaatgtct atggttcgga
     9421 aatcattgga tgcttgggga gtttatattg gtatacctgc taaatttcta aaaaatagaa
     9481 ataaaaatat gcaaagtttg atttatggga aagaataata gaattccatt agtctctgtt
     9541 tgttgtatga cctataatca tgataaattt atttctcaat gcttagatgg tattattcaa
     9601 caaaaaggta acttctctat tgaaatattg attcatgatg atgcttcttc tgatcataca
     9661 cgacaaataa tagaattcta tagagataag tatccagata ttataaagcc tctatatcaa
     9721 gaaattaatc aatattctcg gggggttaat atatggaaca cttatatgtt tccattggtt
     9781 aaaggagaat atattgctat atgtgatggg gatgactatt ggatagatca atataaattg
     9841 gagaaacaaa taactttctt gcaaaaatat gctgactata atttggttta tacaaataaa
     9901 attgttataa acgaattagg aaccagagta attaggaatc atcctaaata tttatcggga
     9961 aatttgtttg tgaatttgtt aagtggaggt aatcctatta caacatctac tgtatgtatt
    10021 cgaactcatg atgcatttga aataatggat attgtaaatt ctattccatt tagaactgta
    10081 atgggagatt tacaattatg gttagcttta gccataaaag gaaagtttaa atatttggct
    10141 tttaaatcta ctgtctatag attatcctct atttctctta gccattcttt gagtgtaaat
    10201 cgggaaataa gattttcaaa acatgaatat tttattaaaa aatattttgt agatatattt
    10261 caggtaaata ttgataaaaa tatattggaa cgaacatatt ataagaatac aattcgtcga
    10321 ttattttcat ttagaaaaga aatttttttg agttacgttt ttaagtctgt gaaaaaagat
    10381 ccattcttga tttttgatat aaagataata acattagtgg gggtgaaatt attaaaatcc
    10441 attttatgaa agttttattg gtatttatag atatgatgag aacagattta cta
//
