LOCUS       c00042_gnlPro..        15114 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPPCAGAM_42.
ACCESSION   c00042_gnlPro..
VERSION     c00042_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 14:39:48
            Original ID  :: gnl|Prokka|JPPCAGAM_42
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15114
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15114
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2155:5114]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2156..5114
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15114
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15114
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(2..505)
                     /locus_tag="ctg42_1"
                     /transl_table=11
                     /translation="MNIFSFTAHFGSEEDCRLHFKEQRDKEGVVCKRCGGTSHYWLQGK
                     WSYECKGCRFRTSLRSGTIMESSKLPFLVWYKTMFLMSCTKKGFSTNELQKQLGLKRYE
                     PVWAMVHKLRRAMGNRDARYTLEGMIELDEGYFSVASKEIERGKGTRGRGAEGKQNVAV
                     MAEST"
     CDS             complement(613..1578)
                     /gene_functions="resistance (resist) CfxA (Score: 687.1;
                     E-value: 1.7e-209)"
                     /gene_kind="resistance"
                     /locus_tag="ctg42_2"
                     /transl_table=11
                     /translation="MKKSRRKRLVILCIALVCIIVLVFLLFSKSTSNNSTNPPLTDVLT
                     DSISRIVSACPGEIGVAIIINNTDTVKVNDKSVYPMMSVFKVHQALALCNDFDNKGISL
                     DTLVKIDRNRLDSKTWSPMMKDYSELVISLTVRDLLRYTIAQSDNNASNLMFKDMVNVA
                     QTDSFIATLIPRSSFQIAYTEEEMSADHDRAYFNYTSPLGAAMLMNRLFTESIVSGEKQ
                     SFIKNTLKECVTGTDRIVAPLLDKERVSIAHKTGSGYVNENGILAAHNDVAYICLPNNV
                     CYTLAIFVKDFKGNESQASQYVAHISEVVYSLLIQNSAIP"
     CDS             1608..1736
                     /locus_tag="ctg42_3"
                     /transl_table=11
                     /translation="MTDPDLLFTAKIRNLTENELVVFFVCSVFYQIIFRANMIRLK"
     CDS             2156..4384
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_4"
                     /sec_met_domain="Gly_radical (E-value: 2.9e-46, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1167.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             4389..5114
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_5"
                     /sec_met_domain="Radical_SAM (E-value: 3.9e-30, bitscore:
                     97.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEAGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFRTVQVN"
     CDS             complement(5346..6608)
                     /locus_tag="ctg42_6"
                     /transl_table=11
                     /translation="MMKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYP
                     YRRWAVAAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAV
                     SEPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLAEKRPEAVTEEKRTEPQQEATAAIE
                     KKESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSENF
                     APRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVMDYEHHQPVSFGLSVR
                     KSLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVS
                     AGGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKV
                     QTIRKERPCNFNLQAGLRFTY"
     CDS             complement(6660..7208)
                     /locus_tag="ctg42_7"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             7396..8148
                     /locus_tag="ctg42_8"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGEEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(8253..9251)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.5; E-value: 38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg42_9"
                     /sec_met_domain="LysR_substrate (E-value: 2e-46, bitscore:
                     150.3, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 6e-18, bitscore: 57.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVKLKISIFALIDSISLINQRTMTIQQLEYILAVDQFRHFAKA
                     AEYCRVTQPTLSAMIQKLEDELGVKLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKE
                     IISEEQHSLSGTFRLAVLPTIAPYLLPRFFPQLMEKYPDLDIRVMELKTPDIRKALLTG
                     EVDAAIIASMLDDAALTEETLFYEQFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGH
                     CFRDQLVRFCQMEAVKISQMAYRLGSMETFMHMVESGKGITFIPELAVMQLSEEQKELV
                     RPFAIPRPTRQIVLVTRKDFIRTSLLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             9321..9794
                     /locus_tag="ctg42_10"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANRYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(9876..10874)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_11"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 1.8e-69,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(10929..12197)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_12"
                     /sec_met_domain="MFS_1 (E-value: 5.1e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(12447..13460)
                     /locus_tag="ctg42_13"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVALKGVMGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(13483..14592)
                     /locus_tag="ctg42_14"
                     /transl_table=11
                     /translation="LLACFVLPMILAGCNDADYQVIDNAIYLNEASENGSAKVTVDPEN
                     VTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTYDKEIKIAAG
                     DVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDKPLIQSVPFM
                     NTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVYIRFGDAMIP
                     YNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQTKGGPVRFD
                     KMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGYWKMDEGKGN
                     AFVDCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 gggtgctttc ggccatcacc gcaacgttct gctttccctc ggctccccgg ccacgtgtac
       61 ccttgcctcg ctcgatttcc ttactggcca ccgaaaagta accctcatcc agttctatca
      121 tcccttccag tgtatacctt gcatcccggt tgcccatcgc cctgcggagt ttgtgtacca
      181 tcgcccatac cggttcgtaa cgcttcaatc ctaattgctt ctggagttcg ttggtggaga
      241 atcccttttt tgtgcaactc atcaggaaca tcgttttgta ccacaccaga aacggcagct
      301 tggagctctc catgatcgta ccgctgcgca acgaggtgcg gaaacggcaa cctttgcatt
      361 cataactcca tttaccctgt aaccaataat gggaagtgcc cccgcatcgc ttgcagacaa
      421 ccccttcctt atcacgctgc tccttgaaat gcaaacgaca atcttcctcc gaaccgaaat
      481 gagccgtaaa actgaatatg ttcataatcc ctgctttttg agcgctaata tactaaaaat
      541 attaggtgtg tttgcggaga atcagaataa attatataat gtttaccatt gaagcttcaa
      601 agtaaacgca acttaaggaa ttgccgaatt ttgtattaat aaagaatata cgacctctga
      661 tatatgcgca acatattgtg atgcttgtga ttcattaccc ttgaaatcct taacaaatat
      721 cgctaaagta tagcagacat tattaggcag gcatatatag gcaacatcat tgtgagctgc
      781 aagaatacca ttttcattga cataaccaga acccgtctta tgtgcaatag aaaccctttc
      841 tttatcaaga agcggagcga ctattctatc tgtacctgtc acacattctt ttaatgtatt
      901 cttaatgaaa ctttgcttct caccactgac aatactttcg gtaaacaaac ggttcatcaa
      961 cattgcggca ccaagaggag atgtataatt aaagtaagcc ctatcgtggt cagccgacat
     1021 ttcctcttct gtataagcta tctgaaaact tgaacgagga ataagtgtgg ctataaaact
     1081 gtcagtttga gcaacattga ccatatcttt aaacatcaga ttgcttgcat tattatcact
     1141 ttgagcaata gtataacgaa gtaaatctct cacggttaat gatataacca actcggaata
     1201 atctttcatc ataggactcc aagtctttga atcaagtcta ttcctatcta tctttactaa
     1261 ggtatcaagt gaaatccctt tgttatcaaa atcattgcaa agagctaatg cctgatgaac
     1321 cttaaataca ctcatcatag gatatacact cttatcatta actttaactg tatctgtgtt
     1381 attaataata attgccactc caatttcacc aggacaagct gatactatcc gagaaatgct
     1441 atcagtcaaa acatctgtca aaggtggatt tgtactatta ttagaagttg atttagagaa
     1501 caataaaaaa actaaaacta tgatacaaac taaagctata cacaaaatta caaggcgttt
     1561 tcttctactt tttttcatac tacgattttt aaacattata tattatcatg acagaccctg
     1621 atttattatt tactgcaaag atacgaaatc ttacggaaaa tgaattggtt gtttttttcg
     1681 tttgttctgt tttttatcaa attattttcc gagcgaatat gattcgtctt aaataaaata
     1741 aaaacaccca actttatatt cttgggtgta aaattgggtg tttgttttat aatttgctga
     1801 ttttcagcgt ttattgcgga gagacaggga ttcgaacccc gggtacctcg cagtacaacg
     1861 gttttcaaga ccgccgcaat cgaccactct gccacctctc cagaactacg gttaagtagt
     1921 gcttttctct taaagcgctg caaaggtacg aatcattttt taacttgcaa attattccgc
     1981 aaaaaaatat tagaaaagta tatttggaag taataactgc tatctggctt ctccccataa
     2041 ataggtattt ttatgctatt caacataaaa taggaccctt ttatatacct aaaccgaaaa
     2101 aaggttgtaa atttgcgcgc tctaaaggat aactaaccac taactgatta attttatgga
     2161 actgaataag acctttaaag atggactttg gagcaaagaa atcaatgtaa gggatttcgt
     2221 tagtaacaac atcactcctt atgaagggga tgcttctttc ctgcaaggac ctaccgaacg
     2281 caccaaagct gtctggaatc actgtctcaa agctctcgaa gaagagagaa acaataatgg
     2341 tattcgtgca ctcgactaca caactgtatc tactataacc tctcaccctg ccggctacat
     2401 cgataaagaa aacgaactga tcgtcggact acagaccgat caggtgttaa aacgtgccat
     2461 caaaccgttt ggcggaatca atgtggttat gaaagcttgc cgtgaaaacg gagtggaagt
     2521 agatgacaga gttaaggata tcttcactca ctatcgcaag actcacaatg atggggtatt
     2581 cgatgtgtat accgaagaaa ttcgttcgtt ccgttcattg ggattcctta ccggacttcc
     2641 cgacaactat gcacgcggac gtatcatcgg tgattatcgc cgcctggctc tctatggtct
     2701 tgaccgtctg atagaagcta aaaaagaaga tctgcataat ctgacaggtc ctatgactga
     2761 agcccgcatt cgtcttcgtg aagaagtagc cgagcaaatc aaggccctga aagagattaa
     2821 agtattgggc gaatattatg gtttggatct gagccgaccg gcatataccg cacaggaagc
     2881 tgtacaatgg gtgtatatgg cttatctggc tgccgtaaaa gagcaggatg gtgctgccat
     2941 gtcactgggt aatgtatctt cattcctcga catctatctt gaatatgaat taagccaggg
     3001 tacgataacc gaaacattcg ctcaggaact gatcgaccaa ttcgttatca aactccgtat
     3061 ggtacgccac ttgcgtatgc agtcgtacaa cgatattttt gcgggtgatc ccacatgggt
     3121 gaccgaatct atcggtggac gtttcaatga cggacgtacc aaagttacta aaacttcttt
     3181 ccgcttcttg cagacacttt ataacttagg cccgtcaccg gaacctaaca tgactgtact
     3241 atggagccct gagttacccg aaggcttcaa agcattctgt gcacaagtat ctatcgacac
     3301 ttcttccgta caatacgaaa acgacgacct gatgcgtgaa gtccgtcaat cggatgacta
     3361 cggaatcgct tgttgtgttt catatcagga aatcggaaag cagattcagt tcttcggcgc
     3421 acgtgccaac cttgccaaag ccctgctact ggctatcaac ggaggacgtt gcgaaaatac
     3481 aggtacagtt atggtaaaag acatccctgt attgaccggt gaaacactga agttcgaaga
     3541 agtaatggcc aactataaga aagtattgat acaaattgca cgtgtataca acgaagcaat
     3601 gaatatcata cattacatgc acgataagta ttactacgaa aaggcgcaga tggctttcgt
     3661 ggatactgat ccccgcatta acctcgctta tggtgtagcc ggactttcaa tcgccatcga
     3721 ttcactgtcc gccatcaaat atgcacatgt gaaagcccgt cgcaacgaca tcggactgac
     3781 ggagggattc gatatcgaag gtgctttccc ttgtttcggt aatgacgatg accgtgtaga
     3841 ccacctgggt gtggacctgg tatatttctt tagcgaagaa ttaaagaaac tccccgtata
     3901 taagaatgcc cgtcctaccc tttcgctgct gactatcact tcgaacgtaa tgtatggcaa
     3961 gaagaccggt gccactcctg acggacgcgc caaaggcatt gcctttgctc ccggtgccaa
     4021 ccccatgcac ggacgtgata aaaatggtgc aatcgcctca ctgagttctg tagccaagtt
     4081 gcgttatcgc gactcacagg atggtatcag caatacgttc tcgatcgttc ccaaatcatt
     4141 gggagcaaca caagaagacc gtatcgacaa tctggtgacc atgatggacg gatattttac
     4201 aaaaggcgca caccacctga acgtaaacgt gctgaaccgg gaaatgttgc aggatgcgat
     4261 ggaacatccc gaaaagtatc cgcaactgac tatccgtgtc tcaggatatg ccgttaattt
     4321 cgtgaaattg agccgcgaac atcagttgga agtaatcagc cgcagtttcc acgaaagaat
     4381 gtaattgaat gataaacgta cactcatacg agtcaatggg aacattcgac gggccgggtc
     4441 tccggctcgt cgttttcctt caagggtgta acttccgttg cctctattgt gccaatccgg
     4501 acacaattga agccaaagga gggacagcaa ccgaccctga ggaaatagtt cgcatggccg
     4561 tcagtcagaa agctttcttc ggtaaaaagg gaggtatcac cttttccggc ggagagccta
     4621 cttttcaagc aaaatcgctt atcccacttt ttaaaagact aaaggaagca ggaatccata
     4681 tttgccttga taccaatggc gggctatgga acaatgatgt agaggaacta ttggaattga
     4741 ctgatctggt tttattagat atcaaagaat ttaatccgga acatcatcag tctttaaccg
     4801 gaagaagcaa cgagcagacc ctgaaaaccg cagcctggct tgaaaccaat cataaaccat
     4861 tctggttgcg atacgtatta gtgcccggct acagtgactt cgaagacgat atccggcagc
     4921 tgggagagca tcttggaacg taccagatga ttcagcgtgt agaaatattg ccttaccaca
     4981 ccttgggtgt tcacaaatat gaagcaatga acaaagaata tatgctgaaa ggagtgaaag
     5041 agaatactcc ggagcagata gaaaaggctg agaaactatt caggcaatat ttccggaccg
     5101 tacaagtgaa ttgacttata taagtgtcga aattcgtatt cgccacagat tacacgaatt
     5161 tacacagata aagatcattg gcaatcaata gattaagttc actctgcggt aaattatgac
     5221 gattgcgctt atttataatt ttgtaagtca cgacataaaa atctccctgt tcttgcctta
     5281 attcattaca atacaaggca agaacaggga gataatgtaa ccggtatatt ttttgccatc
     5341 ctactttaat aagtgaatcg caatcctgcc tgcaagttaa agttacaagg cctttctttt
     5401 cggatggttt gtactttgga gccatcatca aagaaatacg aaactcccgg ttccacatat
     5461 aggccgacat gatctgtcgc attgaattgc gctcccacgg caccggctac agaaaattgc
     5521 aaaggcttca cattcacctt atcatccgcc aactttccat aaacacactt ttcaaccatt
     5581 cctccggcag atacatagag tgtaaaatat ttcttttcca gaaaattcca gtttccacgt
     5641 acaggaatac ctatataatg caatttctga ctctgcatct tggtatcccc ctgccgtttg
     5701 atgtcagaag acaacaacgt ataagtcaat cccgtctcta cagagaaacc tttgggaaga
     5761 gacttacgta cagacagtcc gaagctaacc ggctgatgat gttcataatc catcacggca
     5821 gttgtattgg acttcagata gggaacccct tcttcaaata taacttcctg atcggcagga
     5881 atactcacag ctccattcat gatcgtcatc aagtcgaccc tgttagtcat cggacggggc
     5941 gcaaaatttt cggaaccatt tgtcggaagt ccacctccat taccgatacc cactcccatc
     6001 gaccatttac caccacgttt agcagaagag tctccgatag gcaactgata cttgtcttta
     6061 ccggacggtc gccgcgcttc tttcctcttt ggaggctgcg ccgtcgcact ttcttttttc
     6121 tcgattgcag cagttgcttc ctgttgcggc tcagttctct tttcctccgt cactgcctcc
     6181 ggtcgcttct ctgccaagga ggatacctcc ggaacaatca ccggatcagt attctttgcc
     6241 aaatagcccg aaacagggtt gatactcgtc gttcctaccg gcttaacggg ttcggataca
     6301 gctacctgta catccggcaa ggcaggttcc ggcaatacat ccgggttgac agccagtgaa
     6361 ggagccgttg cataacggat ttcatcagct accggactat tcagaaaata caaactgaca
     6421 gcagtcgtta ccaccaatac cacagctgcc gcagcaaccg cccaccggcg atacggatat
     6481 attcgttttt cggttacagg catcagttcc ctttccagtc gttcccaacc ggaagcaggc
     6541 atcggctccg aataatcttc gagcttatcc ttgaatgctt taatccattt ttcgtcttct
     6601 ttcatcattc tatttcattt ttgaaatcca aggttcacct cagtatctgt aaatacatgt
     6661 caaccattgg tcaccaacca ttctttcact ttctttgcca atacactttt tgcgcgaaaa
     6721 agctgtgagg cagaagattt ttcattaatc cccaacatct gtgcgatttc cttgtgcgac
     6781 ttatcttcaa aggtgtataa attgaatacg gtacgatatc cggcggggag ttcattaata
     6841 aattgcatca gcactttctg tggtattgct tcaacagccg aagcatccgg ttcttcatac
     6901 gtttcgggaa cttcatccag tgccgtggtc tggttcatca cgtcgttctt tcttaagaac
     6961 tgtaaagccg tattcaccat tacacgctcc atccatgctc tcagagagcc ttcaccccgc
     7021 caggtaaact tgtcgaagga gtcgaaaatc ttcaggaaac cgtcgtgtac caagtcttgt
     7081 gccatatccc tgtctccggc ataacgaaga cagacaccaa gcatgcgccc tgcgtactgc
     7141 tcataaagtt ctttgcgggc acgattatct ccctgcctgc aacgttccga cagctctaat
     7201 tcattcattc tcctaaacac gtgtttacct tataaatgca gcaaagatag aaatactgca
     7261 cagagagaac aactctttta tcacttttgt ttctttaaca ttttaggatg caatatttca
     7321 tcacttcctg cattttctca atacaataaa gaataaatct caatggataa ataggataaa
     7381 accaacaaga aacttatgaa gaaatttaat ttaataactt ttgccgtcat cctgatgtta
     7441 ttgcccattt tacagtcatg tctggacgat gccaacaacg acgagtgggt cacttgtcct
     7501 ccgggtggaa tattggccat cggcacaatg aagattccca atgcggacac tccaagggac
     7561 tttttcattg cattggacaa tggagacaat gtacttccgg cagatacggc cgatatacgc
     7621 aacaggaaat acactgttgc agaaggtcaa agagtcttcg ttggctatct gcagatggga
     7681 gaagagaaac ccggatatga gaacggtaaa atattcacga tagaagatat attgacgaaa
     7741 gagatcattc cactgacgga agctacagca gacagcattg gagacgaccg tatcaacgtc
     7801 acagcgcatg cacttacgaa agattatctg accatcgaat atcaatatct gggcagcatg
     7861 aatgaaaata aaaaacacat gctgaacttg gtacaaaacg aaataacagg tcccataaaa
     7921 gatgacggat atatctatct ggagttccgg cataatgcct ttaatgactc ccccaatcaa
     7981 ttgggttcga gccttgtttc tttcaagctg gatagtatag ccgagcaatt ggcgacagcc
     8041 aaaggaataa aactccgtgt gaacaccatt tatgacaata tacagtatgt cacaatagat
     8101 atcaacgaag acaaaaactt aaaaataaaa tcatttcatt ctcaataaaa caacaagaaa
     8161 cacctacaca atcaggcaaa acgagtaata attctgatac ataaaagaaa taaggcggcg
     8221 atgtttgtga aaatatcgcc gtcgttttta tattatacca gacactgaac ggcctgcagg
     8281 gtaagcatct ccttgggaac cgccgcctga atctcctctt tcaaaacctg cagcagactg
     8341 gtgcggatga agtctttccg ggtcaccagg acaatctgac gggtaggccg cgggatagca
     8401 aacggacgga ccagttcttt ctgctcttcg ctcaattgca tcactgccag ttcgggaata
     8461 aacgtaatcc ccttaccact ctccaccata tgcataaagg tttccatact acccagccga
     8521 tacgccattt ggctgatctt aaccgcttcc atctgacaaa aacgaaccaa ctgatcgcgg
     8581 aagcaatgcc cttcgtcaag aagccaaagc cgttcccctg tcacatcgga cgtacgaatc
     8641 acatcgtgct tgaacaacgg ttccttcttt gagacatagc ccaggaattg ctcgtagaat
     8701 aaggtctctt ccgttaatgc ggcatcatcc agcatgctgg caatgatagc agcatccact
     8761 tcaccggtca gcagagcctt gcgaatgtcg ggcgtcttca gctccatcac ccgtatatca
     8821 agatccgggt atttctccat cagttgcgga aagaaacggg gcagaagata aggtgcaatc
     8881 gtcggtaaca ctgccaatcg gaatgtaccc gacagggagt gctgttcttc gctgatgatc
     8941 tccttgacac agataacttc cgaaagaatc ttacgggcct gttccagcac tttcttacca
     9001 atggcagtag ggcaaaccgg tgtcatgcta cggtcgaaca gtttcacccc caattcgtct
     9061 tccagctttt ggatcattgc actcaaagta ggttgcgtca cccggcaata ctcggcagct
     9121 ttagcaaaat gccggaactg gtccacagcc agaatatatt ccaattgttg tatagtcatc
     9181 gttctctgat ttattaaaga tatagaatct atcaatgcaa agatagaaat tttcagtttg
     9241 acacgaatca ttttgtgccg tatctttgtt ccagataaaa agaagaaata tagtattaac
     9301 tcaaaaaaaa caatatcatt atgaagactt taaattatac acatttggaa gaaaaaggag
     9361 ctaacaccat cgtactgtca ttacagcaac tgcttgccga ttttcagatt cattatgcaa
     9421 acctgagagg atttcactgg aacatcaaag gacacggttt cttcgtactg cacagcaagt
     9481 ttgaagattt atataatgga gccgccgaaa aggtggacga aatagccgaa cgtatactga
     9541 tgctgggagg aactcccgcc aatagataca gtgactatct gaagatggcg cagatcaagg
     9601 aagtggacgg agtgaataag gccgacgacg ctctgaatca tattctcgaa acttacgggc
     9661 atctgattgc ggaagaacgt aaaatcctgt ctctcgcctc ttcacacaac gacgaagtaa
     9721 cagtggccat gatgagcgac tacctgaaag aacaggaaaa gatggtttgg atgctgactg
     9781 catacaacgg ataacagccg aaagggtgta gccatacaag caaaagggtg tagccatccc
     9841 ggcgggatag ctacaccctt tctgttttat tcgattcaga tgatacttgt acgtttggta
     9901 aattcaataa tttccggaat gtatccgaat gcgagcccgg tcactgtatc cgcacaccca
     9961 taatagatgg caatccgtcc ggtctccgaa tcatgaagcg ctgcgcatgg gaaacagaca
    10021 ttaggcacat cacccataca ttcgtaatcc ttctgaggtg aaatcagata aggccccgaa
    10081 cggaatttta ctttccaggg ctgatcgatg tcaagcagtg ccgaaccaaa actatacaca
    10141 aaaccgttgc aggaagccaa tacaccatga tagatcagta accagccttc cgaggtttca
    10201 atcgggatag gccctgcacc gatcttggta cactgccagg cactgtcttc gaacggagcc
    10261 ggcgacataa catgacgatg acgtccccag aactccatat cgggagactc gctatagaaa
    10321 atatctccaa aaggagtatg cccattatca ctcgggcggc tcaacatcgc aaaacgaccg
    10381 tttatcttac gagggaacaa gactccattc cgattgaaag gaataaaggc attctccaac
    10441 tggtgaaaag taacaaaatc ataggtgtag gccacaccga tagtaggacc atgatagcca
    10501 ttacaccagg tcacatagta gcggtcttcg ataaagcaaa cccgtgggtc atatccatag
    10561 acccaggttc caacctcagc atcatcacat tgaaacttta acggttcttc gttgatatcc
    10621 caatgaacag catccttgct gaatcccaca tgcaaacgca tgcgacgatt agtatcatca
    10681 caacggaaca cccctgcata gccatcctta aacggaacta cggcactgtt gaatatactg
    10741 tttgaagtag ggagcaagtc gcgcggaata atcggattgg ccgaacaacg ccacactaca
    10801 tctttacatc ctgccggacg ttcttcccaa ggcatagccg gcaaagcagc acctgcaatt
    10861 ttaatttctt ccatgattcg attaaattaa tattatgtat atatcttgtt tatattgaaa
    10921 atctcttttt atttcttctt tccgtccgga tatgtgaaag gtaccagcca agtcacgata
    10981 aaagccggta tggtagcgat aagtacccag ataaagaaat cgcgataacc cagccaatcg
    11041 ctcaggtatc cgctcatcat tccgggaagc atcacgccca gattcataat accggtagca
    11101 aaagcataat gtgccatctg atgtttgccg ggagccactt gctgcatcat aaagagcatc
    11161 aatccgacaa aaccaaaccc gtaacccaag tattcagaca caatggccat accaataatc
    11221 catagatcgg aaggctggta aagggctaac aggaaatata ccaagaacgg aatattaaaa
    11281 gcgcaacata aagaaaacaa agtcttccga agtccgaaag ccgaaatgta ataaccggcc
    11341 aaaagcgaac cgagaataaa agctcccgct ccgaacgtac catataccag tccgatatcc
    11401 tgagtgctga gtcccaatcc accatccgca accgacgctt tcaggaacaa cggtacaatc
    11461 ttgatggcat atccttcggc aaaccggtac aaaatgataa agacaatgta gaaagcaata
    11521 tgtttttttt ggaaaaaaga gcggatgact tcccaaagca tattcaatgc gtcactcatc
    11581 gtattcactt caccggaagc gcctcctccc gaaggcaaaa tccggatgtg gtaaagaccg
    11641 atcagaatca taatacccgc acacatcaac atgacaatca tccaggcatg taccactcca
    11701 aattcatcct tcagcatacc tgccaaccaa accaagcctc cgttggcaag tatcttggcc
    11761 agattataaa aagctccctg ccaaccgata tacttggctt gctgggtagc agtcagttca
    11821 gtcaggtata ctccgtcccc cgcaatgtca tgagtcgcac cactgagagc aatgatcccc
    11881 atcagagcga tggcataacg aaaaaagtcg ggcagcggca gcgaaagtgc taccaatgca
    11941 aatgccagtc cggtaataat ttccgtagcg acaacaaagt actttttcgt tttaaacatt
    12001 tccagaaacg gactccataa aggcttcaat gtccagggaa gcataatgag agaagtccag
    12061 aaagcaatct gtgcattcga cacttccata tcggaaaaca taaggacaga aaccatcgaa
    12121 agggccacaa acggcaatcc catagcaaag taaacagtag gcacccaaca tacagggctt
    12181 atcggctttt tattcatcag ttagtttttt ataataattc catcggttaa caattccagt
    12241 aagcaaagat aggggatatt aaaaacataa cccaagatta cgacaagaag ttgctttcat
    12301 tatttaataa tacaactcac ccgggaaaac tactaacctc tatcaccctt tttttattaa
    12361 actttatcaa tacgacacac gcaaagaagc accgaagact ttcatccccg atgcctctcg
    12421 cccccttatc tacaatctaa acacctctat tgcttcacat ataaatttat ctcagcaaac
    12481 ccggtataat tatccggagt cagacagttt attctgaatt cctttacatt cgggataggt
    12541 ggttcgatgg ccgcatattg cggatcagcc cctttaaaat ttctgaaagt caagactctc
    12601 gggtaagtaa cccactcggt ttcaccctct ttccgaacct taatctcagc acttctcaga
    12661 ttataacccg atccgtaggc actctgttta gtgaccgaaa atccggttaa ggtaacaggc
    12721 cggtccagta ccgtattcca ccaacactct ccggcattag ccactcccca tgtaaaccaa
    12781 gtagtattta tctcaccgtc aatagccaga tgtgcaccat atttggcatc atcatcggca
    12841 taaacattgc tgcaacttac actccacgca cttcgatcta cagcggacca attcccgggt
    12901 ttcgtataac tggtataaag cacgctggta taaatccgga tataaaccgt cttcatagat
    12961 gtactgacag cctgttcgtc catgcccata actcctttaa gcgccacggg aagcacatat
    13021 ccgtcaggat tagtcaactt ttctatattc ttcaaaacga cctgaaaaga tgaatcggcc
    13081 actgtctgtc ccgtttttaa gacaacttca cttgtttcaa tggtataatt atcttggggc
    13141 aacaacttac atttcgtctt attggcagaa ttgtaagtat ccactttcag cgtatctact
    13201 cccaaagcgg cagtgacatc ccgcgtaacc ggctgtacgg cacacaattg tatttcaaaa
    13261 tcagaacggt cggcagtaga ggaattgctc acacaatcca ccactaccgc agcacccatt
    13321 tcggcccccg gtgcaactcc cgttctgata tatatctttt gatatttgtc catttcatca
    13381 tcatcgttgc tgcacgaagc caacgataca aagcctgtta tcaggcagat taaggtcaca
    13441 aaattcaaat gtctattcat atcttatctt ctttttacat agttattgct tatcaaaacg
    13501 aacatgctct ttccagacaa gagttcctcc tgccaccaaa tcgtatccgt gtccggtaca
    13561 gtcgacaaag gcatttccct taccttcatc cattttccaa tagcctatca ggttcggatc
    13621 ggcgggcttc acggcaaaat acatgttgga ctgaatttgc gtctggctga ttgcgctctt
    13681 ccaaagacgc acctgggcca tctgacaatt gttgcggaag tagctaccgc tcgaaaccat
    13741 gttcatcttg tcgaatctaa ccgggccacc ctttgtctgc agagtcacgt cgagcactcc
    13801 gttgatataa atcgacaata acccggaaga attataaacg aaggccagat gataccactt
    13861 attcttctca aacaaagtca ccgtattgac ctgacttcca agtgtcttca cctgtaatga
    13921 attataaggg atcatagcgt caccgaaacg gatataaacc tcgtggtcgc tgctgcccga
    13981 attaaatata gcctgattat taatatcgaa tccgtccatc tgtacccaag cctcgagtga
    14041 ccattcattg gttgtcactc cccacaattc gtccttggcg ggcttcacgg cattggtcgt
    14101 attcataaac ggtacagact gtatcagcgg cttatccagc aaaatgataa acttcgacga
    14161 aagcccgatt gtggacaccg gtccctgaat ttctgtgaga gataccggaa tagcatacaa
    14221 ttctccgttt tcgtttgaat aaggtttcac tctaaactca ctggggattg cgctaacatc
    14281 gcctgccgct atctttatct ctttgtcata agtaaaatac tgctcgggaa ggacttcgta
    14341 cgaagtttca ttagcttcat tgtactcttt aagaatagaa ggatctaccg tcaggacagc
    14401 agtcacattt tcggttacag gctgtcccac acgtacggtc agagtagttg ttgttacatt
    14461 ttcaggatca acggtaacct ttgccgaacc attctcggat gcttcattca aataaatcgc
    14521 attgtcgata acctggtaat cggcatcgtt gcatcctgcc aagatcatcg gcagaacgaa
    14581 acaggcaagc aaatattgtt ttattgttat tcttttcata atcaaattct ttaaagtcat
    14641 tttacagcag gattcattat tctgattgct tcacgcaggt acttatattc gatgtcgccc
    14701 ggatagtcat attccatgtg ataggtgcct actccaccct tccgtacctg ttttccgtca
    14761 atagtcggag tccagcgtgc catgccggca agtgctctca ttttgtttcc gtaacgatct
    14821 acataatcac ctcctcctgt cggagcataa gattcgaaat tctccgtaac gatgtacata
    14881 ttagccactt tctccggagg aagtattcct ttaaagttgg caatcgtacc agccagacgt
    14941 ctgtcaagat tagcatcgga attacccgca aggttagagt atgcctgcac aatgaaatag
    15001 tcaaagtaag gcccggtttc cggatgaata ctttgaggct cgccatcaat cacaagtaac
    15061 cgtcccgtac ccgatttagg tccgattctt tctcccagtg ctttcacgaa agtg
//
