LOCUS       gnlProkkaDEAPHNHP_269  14640 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DEAPHNHP_269.
ACCESSION   gnlProkkaDEAPHNHP_269
VERSION     gnlProkkaDEAPHNHP_269
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 07:31:18
            Original ID  :: gnl|Prokka|DEAPHNHP_269
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14640
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..843
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg269_1"
                     /sec_met_domain="PF04055 (E-value: 6.5e-19, bitscore: 58.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPVDEMRSVDGTVKYLYQVSDNHFVEAVYIPDEDRATLCVSSQ
                     VGCKMNCKFCMTGKQGFTASLTANQILNQIAALPERDKLTNVVMMGMGEPLDNLDEVLK
                     ALHILTASYGYGWSPKRITLSSVGLRKGLQRFIEESECHLAISLHSPFPSQRSELMPAE
                     RAFSIKEMVDLLKNYDFSKQRRLSFEYIVFKGVNDSLIYAKELLKLLRGLDCRVNLIRF
                     HAIPGVDLEGAGMEAMTSFRDYLTSHGLFTTIRASRGEDIFAACGMLSTAKQEESNKN"
     protocluster    1..14640
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7536:7890]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7537..7890
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14640
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14640
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             918..1964
                     /locus_tag="ctg269_2"
                     /transl_table=11
                     /translation="MKKYLFYLSMALVAVVLFSCKSGKKSVFTPTSSGRAYEVLVVVEK
                     PVWERPAGRALYNVLDTDVPGLPQSERSFRIMSTSPKDFDAILKLVRNIIIVDIQDIYT
                     QPKFKYAKDVYASPQMILTIQAPDEASFEKFVEENKQPIIDFFTRAEMNRQISFLEKNH
                     NDYISTKVGSMFNSDIWLPAELSSSKTGEDFFWAGTNAATGDQNFVIYSYPYTDKDTFT
                     KEFFIHKRDSVMKANIPGAKEGMYMATDSSTVEVRPIDIHGDYTMEARGLWRIKGDFMG
                     GPFVSHTRLDKASHRIITTEVFIYSPDKMKRDLMRRLEASLYTLQLPTEKAQEQIPMGI
                     EQEEKTNK"
     CDS             1969..3066
                     /locus_tag="ctg269_3"
                     /transl_table=11
                     /translation="MEDNKIKIGITQGDINGVGYEVILKTFADPVMLELCTPVIYGSPK
                     VAAYHRKSLDLPTNFSIVNTAAEAAHNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     KAIEEFREGLIDVIVTAPINKHTIQSEGFAFPGHTEYIEQRLGNGSKSLMILMKEDFRV
                     ALVTGHIPVREIASSITKELIQEKLAIFNRSLKQDFGIGAPRIAVLALNPHAGDDGLLG
                     TEEQEIISPAIQEMAAKGILCYGPYPADGFMGSGNFTHFDGVLAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDTVDDDI"
     CDS             3091..4317
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 389.6; E-value:
                     3.4e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg269_4"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNTEALTRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGEDVLLLFRKFASDFAEKYRMPAIQLTEDAKRV
                     LLSYSWPGNVRQLKNITEQISIIETNREINAPILQSYLPAQSTQRLPALFGVKTGKSFE
                     SEREILYQVLFDMRQDVTELKKLVHEIMSERGAVTSNVGTFYTPAPVVAPTPSVPAIIH
                     PVKPNCPDDDDIQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAKDLNISERTLY
                     RKIKEYGLE"
     CDS             4325..4825
                     /locus_tag="ctg269_5"
                     /transl_table=11
                     /translation="MRISLLVFTLVVGISCTVSYKFNGGNINYDKVKTISIADFPIKSD
                     YVYAPLGTKFNEDLKDIFLRQTRLKLVNNNADLEIDGEITGYNQYNQAVSADGYSSETK
                     LTITVNVRFVNNTNHEQDFEQQFSAFRVYDSRELLTAVQDGLIAEMTKEITDQIFNATV
                     ANW"
     CDS             4831..5586
                     /locus_tag="ctg269_6"
                     /transl_table=11
                     /translation="MISANLQQWIQHPETLNKDTLYELRTLVTRYPYFQSLRLLYLKNL
                     YLLHDISFGAELRKAILHVADRRKLFYLIEGERYILKPRKKNALPETEVLEEEPSLDRT
                     LSLIDAFLATVPEEVSAQTSLDYATDYTTYLLQEDDTPELEETPKLRGHELIDGFIERS
                     EEETSIRLQPADENKAISEEEESETHHEEDEDDSCFTETLAKIYVKQHRYSKALEIIKK
                     LSLKYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             5591..5971
                     /locus_tag="ctg269_7"
                     /transl_table=11
                     /translation="MYLLLVILMVIAAILMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIMEQAQQEEQTNPYNLPVGTTA
                     PKTDAAAPVEAPATETPATPAN"
     CDS             6142..7530
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 97.1; E-value: 1.4e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg269_8"
                     /transl_table=11
                     /translation="MTEQLKNKLSDSKTLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACILMVLGCGLKYY
                     AISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILLCLIMLCIGTIAFFIYTF
                     YDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCVLFYSAVFPFIKYATDLM
                     VQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATLMIIGAVMLIGVHTLFAL
                     PILNVWWFATVIMIVLGIAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFACFGVLALIVALMLKAEDKKKGYGLQEA
                     NIKK"
     CDS             7537..7890
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg269_9"
                     /sec_met_domain="PF05402 (E-value: 2.2e-17, bitscore: 53.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 3.1e-10, bitscore:
                     29.8, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADVKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR
                     FLLPKGMSADIHVRLEDHGTAVWELIDGKRTVRRIIEELAEHFNYEENYESRITAYITQ
                     LQKDGFVKLVIEN"
     CDS             complement(8023..9078)
                     /locus_tag="ctg269_10"
                     /transl_table=11
                     /translation="MKKLIILTGLLLSTSAYAQTEVTAGVTRGKDYGVTYALPKTAINI
                     EVKVNKVTYTPGEFSKYADRYLRLTDVSGEPQEYWEVVSVKAKSVGIPDSEHTYFVKLK
                     DKTVAPLIELTEDGIVKSINVPLSPKKSAPMQPATTQKKKINPRDFLTEEILMAGSTAK
                     MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD
                     EKIFNIRLTPDKEMDNEVAFRFSKKLGIVANNDLAGEPVYITLKNLKTVNVPEDDGKKK
                     VDGIAYNVPGKAQVILTEGKKQWFNGELPVTQFGTIEYLAPALFNKKSTVQVTFNPDTG
                     GLIKVDREEGE"
     CDS             complement(9151..10662)
                     /locus_tag="ctg269_11"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITERWDI
                     TTPVTVFAGPGNNGGDALAVARMLAEKEYKVEAYLFNPKGELSADCQTNKELVEMMDNV
                     KFSEVSTQFVPPALTMDHLVVDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSG
                     LMGEENTFNVKANIIRAQLTLSLQLPKLAFLFAENSEFVGEWKLLDINLSREAIEETES
                     NYALLEAEEIHALIKPRNTFSHKGNFGHALLIAGSYGMAGASILAARACMRSGVGLLTV
                     HAPIRNNDILQISVPEAIIESDASDTYFACPTDTDDYQAVGIGPGIGCSEETEAALLEQ
                     LSGCQTPLVLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKAC
                     ELARTAKVHIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLAQGYPA
                     EEAAKIGTYVHGLAGDFARKKQGVISMTAGDIISNLPLAWRLVSE"
     CDS             complement(10706..12046)
                     /locus_tag="ctg269_12"
                     /transl_table=11
                     /translation="MNNVQQVKTYSQRKISDFLFILWAGGAALLSYSLVYALRKPYTAA
                     GFDGLEAFGMDYKVVVTIAQILGYVLSKFIGIKLISELKRENRMKFILISIILAEASLI
                     LFGLLPAPYNIVAMFLNGLSLGCMWGIIFSFIEGRRMTDILASLLGVSMVISSGTAKSA
                     GLYVMDTLNISEFWMPALIGGVALPLLALLGYALNRLPQPTAEDIAMKSKRETLNGKQR
                     WELFKNFMPFLTLLFIANVVLTILRDIKEDFLVKIIDVSQYSSWMFAQVDSVVTLIILI
                     IFGLMVFVRSNLKALSILLGLIIASMVVMAVVSFGYEQLQLNAIVWLFIQSLCLYLAFL
                     TFQTIFFDRFIACFKIRGNVGFFIAMNDFLGYTGTVIVLAVKEFFSPDINWTAFYNLMA
                     GYVGIICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY"
     CDS             12352..12987
                     /NRPS_PKS="Domain: oMT (51-151). E-value: 4.4e-15. Score:
                     46.5. Matches aSDomain: nrpspksdomains_ctg269_13_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 99.4; E-value:
                     3.9e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg269_13"
                     /transl_table=11
                     /translation="MNKRGFVSRILQNFRKPEGFFGRMILWGMNTGHASLAQWGMSCLQ
                     WQPEWSVLDIGCGGGANLLQILQRCPQGKAYGIDISSESVTFARKKNKKYLGTRCFIEQ
                     GGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLICCEISDPANKAW
                     TGLVEGMEIHSCDELKAILSKSGFTDTTIFRTKKEELCLVSHRQTVRL"
     aSDomain        12505..12804
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg269_13_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="4.40E-15"
                     /label="ctg269_13_oMT.1"
                     /locus_tag="ctg269_13"
                     /protein_end="151"
                     /protein_start="51"
                     /score="46.5"
                     /tool="antismash"
                     /translation="VLDIGCGGGANLLQILQRCPQGKAYGIDISSESVTFARKKNKKYL
                     GTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLI"
     CDS             13135..13320
                     /locus_tag="ctg269_14"
                     /transl_table=11
                     /translation="MLTSYSSLIKILLFDNQLLIFWMRSVVKFFSYVQDVRSCLFIKLP
                     LRLSIACLSTYFHILL"
     CDS             13671..14219
                     /locus_tag="ctg269_15"
                     /transl_table=11
                     /translation="MLKLFLTNVVLETTDSDKHWYVVLTRTNSERKVRDYFQLQEVDTF
                     LPVQNRVIEREGKRIERERLLLPRMVFVHISRQEMAAVRSTLNVYDFLRDRSTGAPTCI
                     PDAQMADFRYMLDYSQDQVILTGESIPKGTRVVVAKGDLQGLRGELVRYNNKYHILVRI
                     DMFGSAMVTIPASYVRKEK"
ORIGIN
        1 atatccgcgc ctgttgatga gatgcgttcc gtagatggta cggtgaagta tctttatcag
       61 gtgagtgaca atcattttgt tgaagcggtg tatattccgg acgaggatcg ggcgacattg
      121 tgcgtgtctt ctcaggtagg ctgtaaaatg aactgtaagt tctgcatgac gggtaaacaa
      181 ggatttaccg caagtctgac agccaatcag atcttgaatc aaatcgcagc attgccagag
      241 cgggataagt tgactaatgt cgtgatgatg gggatgggcg agcctctcga taatttggat
      301 gaagtattaa aagcactgca tatcctgacc gcttcgtatg gatacggatg gagccccaag
      361 cgtattactt tgtcgtctgt aggattgcgg aaaggacttc aacgctttat tgaagaaagc
      421 gaatgtcatc tggctatcag cctgcattct ccttttcctt cacaacgttc tgagctgatg
      481 ccggccgaaa gggctttctc gattaaagaa atggtcgatc tgttaaaaaa ctatgatttt
      541 agtaaacagc gcagactttc gtttgaatac attgttttta agggcgtcaa tgattcgctg
      601 atttatgcta aggagctgtt gaaattgctg cgtgggcttg actgccgggt gaacttaatc
      661 cggtttcatg ccattcctgg ggtagacctc gagggtgccg gtatggaggc tatgacgtca
      721 tttcgtgact acctgacctc acatggactg ttcactacca ttcgagcttc ccggggagaa
      781 gatatttttg ccgcttgcgg gatgttatcg acggctaaac aggaggagag taacaagaat
      841 taatataaat tatcagcaca ttggatgaaa gtatacgacc atttcgtaga tttgtgaaaa
      901 cattaaaatt gatgcatatg aaaaagtacc tgttttacct cagtatggct cttgtagcag
      961 tagtgttgtt ttcttgtaaa agcggcaaga agagtgtgtt tactccaact tccagcggac
     1021 gtgcttatga agtcctcgtt gtggttgaga agcctgtgtg ggagcgtcct gccggtagag
     1081 ctttgtacaa tgtgcttgat acagatgtgc ccggacttcc gcaatcggaa cgttcgttca
     1141 ggatcatgtc tacttctccc aaagattttg atgccatcct gaagttggtg cgcaacatta
     1201 ttatcgtaga tatacaggac atttataccc aacctaaatt caagtatgcc aaggatgtat
     1261 atgcatctcc ccagatgatt ttgactattc aggctccgga cgaggcatcg tttgagaagt
     1321 ttgtcgaaga gaacaaacag ccgattatag acttctttac ccgtgccgaa atgaaccgtc
     1381 agatctcttt cctggagaaa aatcataatg actatatttc aacgaaagta ggtagcatgt
     1441 tcaacagtga tatctggctt ccggccgaac tgagcagttc gaagacagga gaagactttt
     1501 tctgggcagg tactaatgcc gctaccggag accagaactt tgtaatctac tcttacccgt
     1561 atacagataa ggataccttt acgaaagagt tctttatcca taagcgcgat tcagtgatga
     1621 aggctaatat tccgggtgcc aaagagggta tgtacatggc gactgattcg tctaccgtag
     1681 aggttcgtcc gattgatatt catggagatt acacaatgga agcacgcgga ctgtggcgca
     1741 taaagggcga tttcatgggt ggcccgtttg tttcgcacac ccgtctggat aaagccagcc
     1801 accgtattat cactacagaa gtatttattt actcacccga taaaatgaaa cgtgacctga
     1861 tgcgccgatt ggaagcatct ctgtatactt tgcaacttcc taccgagaag gcgcaggaac
     1921 agattccgat gggcatagag caggaggaga aaactaacaa ataacaaaat ggaagataac
     1981 aaaataaaaa ttggcatcac tcagggagac ataaatgggg taggatacga agtcatttta
     2041 aaaacgtttg ccgaccccgt catgttggaa ctctgtacac cggtcattta cggctctccg
     2101 aaagtggctg catatcaccg caagtcgctt gatttgccta ctaacttcag tattgtcaat
     2161 accgctgcag aagctgccca caatcgcctg agcgtggtca actgtacgga tgacgaggtg
     2221 aaagtagagt tctcaaaacc cgatccggaa gccggtaaag cagctttggg agcacttgag
     2281 aaggcgatag aggagttcag ggaaggcttg atcgatgtca tagtgacggc tcctatcaat
     2341 aagcatacga ttcagtccga aggatttgct tttcccggac atacggaata catcgaacaa
     2401 cgtctgggga atggttcaaa atcactgatg atcctgatga aagaggattt ccgggtagct
     2461 ttggtaacag gacatattcc ggttcgtgag atagcctctt caataaccaa ggaactgatt
     2521 caggagaaac ttgccatatt caaccggtcg ttgaaacagg atttcgggat tggtgcaccg
     2581 cgcatcgcag tgttggcact gaatccgcat gccggagacg acggattgct cggtacggaa
     2641 gaacaggaaa tcatttctcc tgctattcag gaaatggctg ccaagggaat cttgtgctat
     2701 ggcccttatc cggctgacgg atttatggga tcgggcaatt tcacccattt tgacggagta
     2761 ctggccatgt atcacgatca gggattggct cctttcaagg cattggccat ggatgaaggt
     2821 gtgaactaca cggcgggttt gccggtgata cgcacttctc ccgcgcatgg cacagcctat
     2881 gatattgcag gaaaaggcgt tgcttgcgaa gattcattcc gtcaggctat ttatgtagcg
     2941 atcgacgtat tccgtaaccg ccaacgtgag aaggaagcac atgccaatcc gttacgtaaa
     3001 caatattacg aaaaacgaga cgacagtgat aaactgaagc tcgatacagt agatgatgat
     3061 atttaatcag gaagggagtt tagtgcgaat atgacaaaag cggaaataca acaggtaaaa
     3121 ctaaggttcg gtattattgg taacactgaa gctttgacgc gtgcgataga tgttgccata
     3181 caggtggcac ctaccgattt gtccgtgcta ataaccggag agagtggtgt tggtaaggaa
     3241 agtttccctc agatcattca ccaatacagt cgccgaaagc atggacagta tattgctgtc
     3301 aactgtggtg ctattcctga aggaaccatc gattcggaac tgttcggtca tgaaaaaggg
     3361 gcttttacgg gagccatcgg tgagcgaaag ggctattttg gtgaagccga cggcggaact
     3421 atttttctgg atgaagtcgg agaattgcct ttgcccacgc aggcacgttt gcttcgtgta
     3481 ctcgagagtg gggagtttat aaaagtaggc tcctccaaag tacagaaaac ggatgtccgc
     3541 attgtggctg ctaccaatgt caatttgacc caggccattg cagagggacg tttccgtgag
     3601 gatttatact atcgtctcaa tacggtgccc atccagatcc ctcctttgcg ggagcgtgga
     3661 gaagatgtgc tgttactgtt ccgtaagttt gcaagtgact ttgcagagaa gtatcgtatg
     3721 cccgccatac agctgaccga agatgccaaa cgggttttgc tgtcttattc ctggccgggt
     3781 aatgtgcgtc agttgaagaa tatcacggag caaatctcta taattgagac caatcgtgag
     3841 attaatgccc ctatcttgca atcttatctg cctgcccaga gtacgcagcg attgcctgcc
     3901 ctgttcggtg taaagacagg gaagagcttc gaaagtgaac gtgaaatctt atatcaggtc
     3961 ctttttgata tgcgacaaga tgtgaccgaa ctgaaaaagc ttgtacacga aatcatgtcc
     4021 gagcgcggag cggtaacctc caatgtcggt acgttttata cgccggctcc ggtagtagcc
     4081 cctacaccct cagtgcctgc catcattcat ccggtcaagc ccaattgtcc cgatgacgat
     4141 gacatacaag ataccgaaga gtatgtggaa gagtcgcttt cgttggatga agtcgagaaa
     4201 gaaatgatac gtaaagccct tgaaaagcat catggcaagc gaaaaagcgc ggcaaaggat
     4261 cttaatatat ccgagcgtac cctttaccga aaaataaaag aatatggatt ggaataaaaa
     4321 gataatgcga atttcactgc tggttttcac actggtagta ggaatttcgt gtactgtttc
     4381 ttataagttt aatggtggta atatcaatta cgataaggta aagactatct ctattgccga
     4441 ctttcctatt aagtcggact atgtttatgc accgttaggc actaagttca acgaggacct
     4501 gaaagacatt ttccttcgtc agacccgtct gaaactggtg aataacaatg ccgacctcga
     4561 gattgatgga gagattaccg gatataacca gtataaccag gctgtttcgg ccgacggata
     4621 ctcttctgaa accaagctga ccatcacagt gaatgttcgt tttgtgaaca atacgaatca
     4681 tgaacaggac ttcgagcaac agttctcggc tttccgtgtt tatgattcga gggagttgct
     4741 gacagccgtt caggacggac tgattgcgga gatgactaaa gagattacag atcaaatatt
     4801 taacgcaacg gtagcaaact ggtaattaga atgatttctg ctaacttaca acaatggatt
     4861 cagcatccgg aaacgctgaa taaagatact ttgtacgagt tgcgaacgct tgtcacacgc
     4921 tatccttatt ttcagtcact gcgattactc tatcttaaaa atctatattt gttgcacgat
     4981 atctctttcg gtgccgagct tcgtaaagcc atattgcatg tggctgatcg ccggaagctg
     5041 ttttatctga ttgagggtga acgatatatt ttgaaacctc ggaaaaagaa cgcacttccc
     5101 gaaacagaag ttttagagga agagcccagc ctcgatcgta cgctttccct gatcgatgct
     5161 tttctggcca ccgtgcccga agaggtttca gcccagacaa gcctggacta tgcaacggac
     5221 tataccacct atttgctgca agaagacgat acaccggaac tggaagaaac tcccaaactt
     5281 cgcggtcatg aattgattga cggctttatc gaaagaagtg aagaagaaac atccatccgt
     5341 ttgcaaccgg cagatgaaaa taaagctatc tccgaagagg aagagagcga gacgcatcat
     5401 gaagaagatg aagatgatag ctgtttcacc gaaacattgg ccaaaatata cgtcaaacag
     5461 catcgatatt ccaaggcact tgaaattatt aaaaaattaa gtttgaaata tccaaaaaaa
     5521 aatgcttact ttgcagacca aatcagattt ttagagaaat tgattattaa cgctaaatca
     5581 aaataacaaa atgtacttat tattagttat cttaatggtt attgcagcca tactgatgtg
     5641 cttcattgtg ttgattcaga actcaaaagg cggtggtctt gcttcagggt tctcatcatc
     5701 taaccagatt atgggtgtac gcaaaactac agactttctg gaaaaagcaa cttggggctt
     5761 agctgcattt atggttgtga tgagcattgc tactgcgtat gtcgttccga cttcttcttc
     5821 taaaacacaa gatgtcatta tggaacaggc acagcaggaa gagcagacca acccttataa
     5881 cctgcccgta ggtactactg caccgaagac agacgctgct gctccggttg aagcacctgc
     5941 cacagaaact ccggctactc cggcaaacta acaacagatt ctttttaaga aacgataagc
     6001 gaagctgcaa tttcaaaccg aaacttgcag cttcgcttat tttttgccgt aaaatgcatc
     6061 tttttgttag gcatacaagg cagatttagt tacctttgtt cgcaataaca cttttactaa
     6121 tttctgagtt taaatattac aatgacagaa caattgaaaa acaaattgag tgactccaaa
     6181 acacttcgtt ggagtgtgct cgctctggtc gcgtttacta tgctttgcgg ctatttcctc
     6241 accgatgtaa tgtccccttt aaagcctatg ctcgagaaag agcttctctg ggatagtttg
     6301 gactacggat tctttaccag tgcttacgga tggttcaatg tattcctgct catgttgatt
     6361 ttcggtggta ttattctcga taagatggga gttcgtttca ccggtatggg agcttgtata
     6421 ctgatggtgt tgggttgtgg actaaaatat tatgctatct ctacaacttt tcctgaggga
     6481 gctttgatta tgggtttcaa gactcaggtc tttctggcgg ctttaggata cgctatcttt
     6541 ggtgtcggcg tagagatcgc cggtatcacc gtctctaaga ttatcgtgaa atggtttaaa
     6601 ggtaaagaga tggctttggc tatgggactt gagatggcaa ccgcacgtat cggtaccact
     6661 ttggctatgg tgcttaccgt tcccattgcc gattatttcg gctatacgga tgaaagcggc
     6721 agtttccata ccaatattcc gatgcctatt ttgttgtgcc tgatcatgct gtgcatcggt
     6781 actatcgcct ttttcattta taccttttat gataagaaac ttgacgcttc tttagatgct
     6841 cagggagaag aaccggaaga accgttccgt atgaaggacg ttatgctgat tgtcaccaat
     6901 aaaggcttct ggctgattgc tttattgtgt gtactattct attctgctgt tttccccttt
     6961 attaaatatg caaccgactt gatggtgcag aagtataacg tagaccctaa gctggccgga
     7021 aatattccgg gattactacc gataggtacc atcttcctga ctccgttgtt tggtactctt
     7081 tatgatcgta tcggtaaggg agcgacgttg atgattatcg gtgccgtcat gctgattggt
     7141 gtgcatactt tgtttgcgct tcccattctg aacgtatggt ggtttgccac tgtgattatg
     7201 attgttctgg gtattgcttt ttcactggtg ccttcggcca tgtggccttc tgttccgaaa
     7261 attattccgg agaaacaact gggtactgcc tatgctttga ttttctgggt gcagaactgg
     7321 ggattgatgg gggtacctct gttgatcgga tgggtgttga atacctattg caaaggtcct
     7381 gttgtggatg gagcgcagac ttatgactat actttgccta tggctatctt tgcttgtttc
     7441 ggtgttttgg ctctgattgt agctttaatg ttgaaagcgg aagacaagaa gaagggatac
     7501 ggactgcagg aagcaaatat caaaaaataa cagtatatgg cagacgtgaa agagaaaata
     7561 aatcttctgg atgtaattcc tttccgtagt gaaaatatta cggccgaaaa gggaagcgat
     7621 ggtaccgtta ccattgcttt cccccggttt aaatacgagt ggatgcggcg attcttgttg
     7681 cctaaaggaa tgtctgcgga tattcatgtc cggctggaag atcatggcac tgccgtatgg
     7741 gagttgattg acggaaagag aaccgtacgc cggattattg aagagctggc agaacacttc
     7801 aattatgaag aaaattacga atcacgtatt acggcttata tcactcagtt gcagaaagac
     7861 ggatttgtga aattagtgat tgagaactga ttgcattacg atatactatc ggaatataat
     7921 aaagagactc cggctgatct taaatgaagt gcaccctaaa agttaaacat gaacttttgg
     7981 ggtgcacttc atttaagatc ggccggagtt tttgattatg ttttattctc cttcttctct
     8041 atctaccttg atcaagcctc ctgtatccgg gttgaaagta acctgaacag tcgatttctt
     8101 attgaaaagc gccggagcca gatattcgat ggtaccgaat tgtgtgacag gaagttctcc
     8161 gttaaaccat tgctttttcc cctccgttag tattacttgt gctttgccgg gcacattata
     8221 ggcaatgccg tccaccttct ttttgccatc gtcttccggt acgttgacgg ttttcagatt
     8281 cttcagcgtg atataaaccg gctctcctgc aagatcgtta ttggcaacta tgcccagctt
     8341 cttcgaaaag cggaaggcta cttcgttgtc catttcctta tccggagtga ggcggatgtt
     8401 gaatatcttt tcgtctttat tcaaggtacc cgagaacatt tcggtcatgg cagcctcttg
     8461 ctcttccagg ttggcgagca taatcttcag ttgctcccca tctttgggca tgttgtctgc
     8521 ctgtccgcgt accagggcat ttttactttc acgaatgtta taaatctctt tggcaaccaa
     8581 ctccgccatt ttagccgtag aacctgccat cagaatctct tcggtcagaa aatcacgtgg
     8641 atttatcttc tttttctgtg tcgtggcggg ttgcatcgga gccgattttt taggagatag
     8701 cggtacgttg attgatttta cgataccatc ttcggtcaat tctattagcg gagctactgt
     8761 tttatctttc agcttgacaa aataggtatg ttcgctatcg gggataccga cagattttgc
     8821 tttgacgctg accacttccc aatattcctg aggctcaccc gacacatcgg tcaaccggag
     8881 ataacggtcg gcatacttgc tgaattctcc cggagtatat gtcactttat tgactttgac
     8941 ttcaatattg attgctgttt taggaagtgc ataggttaca ccgtaatctt ttccccgggt
     9001 aactcccgct gtaacttcgg tctgggcata agccgaggta gagagtaaca gccctgtcag
     9061 tataattagc tttttcattt ccggtttatt ttaactggtt taaaaaacaa agttaatgaa
     9121 gttatttgga aaatcataag ttgttaactt ttattcgctt accagacgcc aagccaatgg
     9181 cagattactg ataatgtctc ctgccgtcat gctgataacg ccttgctttt tgcgtgcgaa
     9241 atcacctgcc aggccatgta cataagtacc gattttggca gcttcttcag ccggatatcc
     9301 ctgtgcgagc aaagccagca cgacacctgt caatacatct ccgcttccgg ctgttgccat
     9361 acccggatta cccgtagagt tgaaatagca cttgcccgag ggggtgataa ttgccgaata
     9421 ggctcctttt aatatgatat gtactttggc ggttcgggcc agttcacagg ccttcatcag
     9481 tcgttcgtat gaattctggc atttgcccac catgcgttcc agttctttgg gatggggagt
     9541 cagaatagag cctttgggca atgtggtcag tgcgtggcgg tggttggcca atatgtttag
     9601 tgcatcggca tccagtacca gaggtgtctg gcaaccactg agttgttcaa gcagtgcagc
     9661 ttcggtctct tccgagcatc cgatgcccgg accgattcct acagcctgat agtcatccgt
     9721 atctgtaggg caggcaaagt aggtatcgct ggcatccgat tcgataattg cctccggaac
     9781 cgaaatctgc aggatatcat tgttgcgtat aggtgcatgg actgtcagta agcctacacc
     9841 cgaacgcata caggcgcggg ctgccagtat cgacgcgcct gccatgccgt acgaaccggc
     9901 aatcagcaga gcatgcccaa agtttccttt gtgtgagaaa gtgttacggg gtttgatcag
     9961 agcgtgtatt tcttccgctt ccaataaggc ataattgctt tccgtttctt caatcgcttc
    10021 acgactgagg ttgatatcca acagtttcca ttcgcctacg aattcggaat tttcggcaaa
    10081 gaggaaagcc agtttcggca attgcaggct caatgtcaat tgggcacgga tgatattggc
    10141 ttttacatta aatgtgttct cttctcccat cagtcccgag gggatatcga tggcgactac
    10201 ggtggcaggc gatgcattga tatatttcac tactgccgca aaaccgccac ttagcggctt
    10261 attaagtccc gaaccaaaaa gtccgtccac taccagatga tccatcgtca gggcaggagg
    10321 tacaaactgt gtgcttactt cgctgaactt cacattatcc atcatctcta ccagctcctt
    10381 gttggtctgg cagtcggcag acagttcccc tttcgggtta aacagatagg cttcgacctt
    10441 gtattccttt tccgccaaca ttcgggctac ggcaagggca tctccgccat tgttgcccgg
    10501 tccggcaaat accgtgacgg gagttgtgat gtcccagcgt tcggtgatgg ctttggtcaa
    10561 tgcctgtgcg gcccgctcca tcaggtcgat cgatgcaatc ggttcatgtt ctatggtgta
    10621 agcatccagt ttcttgatgc tgctacttgg aaaaatcttc atggtgaact ttcattttaa
    10681 gttttttgac ccacaaagat agcaattaat atacgaaatc gggaacttct ttttcttctt
    10741 ctttttttct gaatacccct gtctttccgt aattctccct gcggtagcgt tggtgcaggt
    10801 agatgaaaga gcatacaaaa gcaacgaaac agattattcc cacatatcct gccatcagat
    10861 tgtagaaagc tgtccagtta atgtccggtg aaaagaattc tttgacagcc aatactatga
    10921 ctgttcccgt atagcccaga aaatcattca tagcaatgaa gaaacccacg ttacctcgaa
    10981 ttttgaagca agcgataaaa cggtcgaaga agatagtctg gaaagtgaga aaagccagat
    11041 agagacacag actctggatg aatagccaga cgatggcgtt cagttgcaat tgttcgtaac
    11101 caaacgaaac gactgccatc actaccatgc tggcaatgat caatcccagt aatatcgaca
    11161 gtgctttcaa gttgcttctg acgaacacca ttaatccgaa aattatcaga ataatgaggg
    11221 ttactacgct gtctacctgt gcaaacatcc acgaagagta ttgagagaca tcgataattt
    11281 ttaccaggaa gtcctccttt atatctctca agatagtcag taccacattg gctataaaga
    11341 gcagagtgag gaaaggcatg aaattcttaa atagctccca tcgttgcttg ccgttcagtg
    11401 tttcccgttt cgatttcatg gcaatgtctt cggctgttgg ctgtggaagc cggttgagtg
    11461 catatcccaa caaggcaagt agaggaaggg caactccgcc tatcagggca ggcatccaga
    11521 attcgctgat gttcaaagtg tccatgacat acaaaccggc cgacttggcg gtacccgagc
    11581 tgatgaccat actgactccg agtaagctgg caagaatgtc cgtcattcgt cttccctcga
    11641 taaagctaaa aatgattccc cacatacatc ccagtgaaag tccgttcaga aacatggcta
    11701 ctatattata aggtgcgggc aacagtccga acaatattaa cgaagcttca gccagaatta
    11761 tggagatcag aataaacttc atccggtttt cccgttttaa ttcggagatt aatttaattc
    11821 cgatgaattt agaaagtaca tatcctaata tttgcgcgat ggtaactacc actttgtagt
    11881 ccattccaaa cgcttcaagt ccgtcaaatc cggctgctgt ataaggcttt ctcagtgcat
    11941 ataccaatga ataggagagc agcgctgctc cgcctgccca aagaatgaaa aggaaatcag
    12001 aaatttttct ctgcgaataa gtttttactt gctgtacatt gttcataaca tctgcttgtt
    12061 gttttccggt gcaaaaatag gagggtagtg ttacagacct gttactgaat atatgaatgt
    12121 ttattattaa tagatattga taatgaatct gttatgttgt aatgtttatg taatatttat
    12181 gaaacggaaa cgaaaagagc atcgcacctc cgggcatctg ttcgtcataa ttttaacggg
    12241 aagcagatgc atacctgcaa atatctttta ggaaacaaat tccctatttc tgggtattgc
    12301 ctgtttgggc agaaactgta cttttgcctg aaatattaaa tcagcagaca aatgaataag
    12361 agaggctttg taagcaggat cttacagaat ttccggaagc ctgaaggttt tttcggaaga
    12421 atgatacttt gggggatgaa tacaggacat gcatcattgg cgcaatgggg aatgtcatgt
    12481 ttgcaatggc aaccggaatg gagtgtactc gatatcggtt gcggtggtgg tgccaatttg
    12541 ctacagatat tgcaacgttg cccgcaaggg aaagcatatg gcatagatat ttcatcggag
    12601 agtgtcacct ttgcgcgtaa aaaaaataaa aagtatctcg gtacacgctg ctttatcgag
    12661 cagggaggag tccaccgact tccctatcct gattatgcgt tcgatgcggt cactgctttc
    12721 gagactgtct acttctgggg taacctgcag catgctttta cggaagtggc gcgtgtgtta
    12781 aagcccggtg gatcgtttct tatctgttgt gagataagcg atcctgccaa taaggcttgg
    12841 acgggacttg ttgaagggat ggagattcat tcctgtgatg aactgaaggc gattctttcc
    12901 aaaagtggtt ttaccgatac gaccatattc cggacgaaga aagaagaact gtgcctggta
    12961 agccatcggc aaactgtgcg gttgtaacca atgccgggac gctcttacca acgaatacgt
    13021 taacaatgtt aatgcccgta aaagtgcttt ccctccttgt caatagctta ttaacttcgt
    13081 atctctaaag aattaatatc ttgcaattac gaagttaata ttaacgtact gttaatgtta
    13141 acttcctaca gttctcttat taagatatta ttgtttgata atcaattgct tatattctgg
    13201 atgcgttctg tcgtaaaatt cttctcttac gttcaagatg tgcgtagttg tctgtttatc
    13261 aagttaccgt taagactctc catagcctgc ctctccactt atttccacat tcttttatga
    13321 gccacattag tattatgtat attgctgctt tccttatttg caaagagata aattatgtct
    13381 ttgatattca gtcatataac ttcctatgat gaaaataacc tgtgaaaagt tttggagact
    13441 caaaagaagg ttttaccttt gtacccgtaa atatataggc ggacaaatat acttttcttt
    13501 atgtccgata tatgtttaaa ataaaataat tcaacgtatc ggatagtatt caaatccggt
    13561 gcgaatactt tttctgtacc cgattatcat aaaacttaat ttgtaaattg ctgaaaataa
    13621 ggcatgtttt ttgaatattc ctgtttttaa caaattttca tccttagtca ttgctgaaac
    13681 tttttcttac gaacgtagtc ttggagacaa cagatagcga taaacattgg tatgtcgtac
    13741 tgacacgaac taactcagaa cgtaaagttc gggattattt tcaattgcag gaggtagata
    13801 cctttcttcc tgtacaaaac cgtgtcatag agcgtgaagg aaaacgcatt gagcgtgagc
    13861 gccttttgtt gccccgtatg gttttcgttc atatctcccg tcaagaaatg gccgccgtcc
    13921 gaagtacact gaatgtatac gatttccttc gtgatcgttc caccggggct cctacctgta
    13981 ttcctgatgc gcaaatggct gattttcgct atatgctcga ttactcccag gatcaggtga
    14041 tcctgacagg agagtccatt cccaaaggta ctcgtgtagt agttgccaag ggcgatttac
    14101 aaggcttgcg gggagaattg gtccgctata ataataaata tcatatttta gtacgtatcg
    14161 atatgttcgg tagcgctatg gttacaattc cggctagcta cgtccggaaa gagaaataaa
    14221 aagtatatat gtgaagaaaa taccattata tgtaatggcg ataacaatat atgtaacggg
    14281 tgataacaat atatgtaatg ccccgttacg tcgttagata taattctatt ggatattatt
    14341 actcttcttc aggtttcgga agtgcaagtg ctcgtttata gttgacaaaa aagtaagtat
    14401 cccggctttc gaccgaaaag gctatcggtg agaggaaaaa gcgaatttaa cacttaactg
    14461 tttgaaaagt aatgctttca aagtacaagc cttctgtcta caaaagtttc gttttaacac
    14521 agtgttaaag cttgttcttt agatgcaaat aacgagtgtt ttaaatgcaa aaggcttgtt
    14581 gtttacgcac aagaaccaaa cagtctaaaa aagacgttaa caatgttaat tgaagaaagg
//
