LOCUS       c00207_gnlPro..        16365 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DEAPHNHP_207.
ACCESSION   c00207_gnlPro..
VERSION     c00207_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 13:53:56
            Original ID  :: gnl|Prokka|DEAPHNHP_207
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16365
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16365
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3406:6365]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3407..6365
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16365
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16365
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             184..1098
                     /locus_tag="ctg207_1"
                     /transl_table=11
                     /translation="MKSLKGIIYAMISSGTFGLIPLFTIPLMGNMEMNESNILFYRFLF
                     STLMMGAVCLLHKSTLKINMKHLISIIGLGALYALTALFLIYSYHYITSGVATTIHFLY
                     PICVSFLMVVFFKEQKSKSLFLAASLSLIGVALMCWSGGGSIRLMGIGLAALTILTYGI
                     YIVALNQLDIGKLPAEVLTFYVLLGGCVIFFIYSLFTAGISSIPSTKAGFYILALAFLS
                     TVISDLTLILAVKYAGSTTTAILGSMEPLVAVVVGVLVFSEHFTLQSLIGLLLILMSVI
                     IVILADQQKKSKRITEQKIIKPH"
     CDS             complement(1281..1406)
                     /locus_tag="ctg207_2"
                     /transl_table=11
                     /translation="MKGGDRFLERMTVIVTMIFTIFMIIRIGYLRIGLLTLVMCA"
     CDS             complement(1440..2498)
                     /locus_tag="ctg207_3"
                     /transl_table=11
                     /translation="MKVKLLFLVFVLYACGTKTVSEEKSYDRITMTTYENKYDENNRLS
                     EVQLTRTSHHRYEEDSETIDLIDDKSTYYYTYINNEEFTVRRKSKRSGNIKIMGYAPQR
                     EEVLTLNAQGDTIDYLLQKYYDKSKLKLVYVRNINNDYVLHEDNDYEEKNEYDGNGNLT
                     KRVQYYFDIGKKRTTYFFRGLSYEEAKKRIPRTDEDYDIVCDIEKMAGDTLIRKCIKNG
                     IVSSINKTIVDEKGKKEFIFDADMKFTGSFTEFKSDSFDIHVDRIVLDDCTDIDSTYYK
                     NGKEVRCVYLSDTSKRIVLSKYDKWGNMVERVEKTKYFYSQDGEELINEMLQVVRENEK
                     KKESRKRLKISK"
     CDS             complement(3204..3317)
                     /locus_tag="ctg207_4"
                     /transl_table=11
                     /translation="MLNSIKIPIYGEKPEGGYYFQIYFSNIFLRNNLQVKK"
     CDS             3407..5635
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg207_5"
                     /sec_met_domain="Gly_radical (E-value: 5.7e-47, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1167.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             5640..6365
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.9;
                     E-value: 1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg207_6"
                     /sec_met_domain="Radical_SAM (E-value: 8e-31, bitscore:
                     97.7, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEKGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFRTVQVN"
     CDS             complement(6598..7857)
                     /locus_tag="ctg207_7"
                     /transl_table=11
                     /translation="MKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYPY
                     RRWAVAAAAVVLVVTTAVSLYFLNSPVADEIRYATAPSLAVNPDVLPEPALPDVQVAVS
                     EPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLVEKRPEAVTEEKRSEPQQEAIAAIEK
                     KESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSENFA
                     PRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVVDYEHHQPVSFGLSVRK
                     SLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVSA
                     GGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKVQ
                     TIRKERPCNFNLQAGLRFTY"
     CDS             complement(7912..8460)
                     /locus_tag="ctg207_8"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTVLQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             8648..9400
                     /locus_tag="ctg207_9"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGEEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(9505..10503)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.5; E-value: 38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg207_10"
                     /sec_met_domain="LysR_substrate (E-value: 2.8e-47,
                     bitscore: 150.8, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.2e-18, bitscore: 57.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRVKLKISIFALIDSISLINQRTMTIQQLEYILAVDQFRHFAKA
                     AEYCRVTQPTLSAMIQKLEDELGVKLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKE
                     IISEEQHSLSGTFRLAVLPTIAPYLLPRFFPQLMEKYPDLDIRVMEMKTPDIRKALLTG
                     EADAAIIASMLDDAALTEETLFYEQFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGH
                     CFRDQLVRFCQMEAVKISQMAYRLGSMETFMHMVESGKGITFIPELAVMQLSEEQKELV
                     RPFAIPRPTRQIVLVTRKDFIRTSLLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             10573..11046
                     /locus_tag="ctg207_11"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANKYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(11150..12148)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg207_12"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 3.6e-70,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(12203..13471)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg207_13"
                     /sec_met_domain="MFS_1 (E-value: 1e-11, bitscore: 34.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIGMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(13721..14734)
                     /locus_tag="ctg207_14"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQPVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPGGYVLPVTLKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTVLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(14757..15893)
                     /locus_tag="ctg207_15"
                     /transl_table=11
                     /translation="MKRITIKQYLLACFVLSMILAGCNDADYQVIDNAIYLNEASENGS
                     AKVTVDPENVTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTY
                     DKEIKIAAGDVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDK
                     PLIQSVPFMNTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVY
                     IRFGDAMIPYNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQ
                     TKGGPVRFDKMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGY
                     WKMDEGKGNAFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 tatctactta aagaaatgcc caaactgata caaagattat caatgagaga cctctccgca
       61 tggctggaca taactccaca atccttaagt agaatcaggg ccgatatgca ttaattacct
      121 tttggtaact tttcattctt ccctgtaacc tacctttgcg ctcaaatttt aattctgtat
      181 gatatgaaaa gtttaaaagg tattatttat gcaatgattt catcaggtac atttgggctc
      241 attccattat ttacaattcc attaatggga aatatggaaa tgaatgaatc caacattctt
      301 ttttatcgat ttctattttc tacccttatg atgggagcag tatgtctttt gcacaaaagt
      361 actttaaaaa taaatatgaa acatctgatc tctatcatcg gtttaggtgc cttgtatgct
      421 cttacagcgc tatttcttat ttattcctac cattatataa ctagtggagt ggctacaacc
      481 attcactttc tctatccaat ctgtgtcagc ttcttaatgg tagtattctt taaagaacaa
      541 aaatccaaat ctctattctt agcagcctca ctctcactaa tcggtgttgc acttatgtgt
      601 tggtcgggag gaggcagtat ccgattgatg ggtatcggac tcgcagctct tacgatatta
      661 acctatggga tatatattgt tgctctgaat caattggata taggtaaatt acctgctgaa
      721 gtgcttacgt tctatgtgct tttaggcggt tgcgtaatct ttttcatcta cagtctattt
      781 acagcaggta tatcctccat ccccagcaca aaagccggat tttatatttt ggcattggca
      841 tttctatcta ccgtcatctc cgaccttacg ttgattttag cggtaaaata tgccggttcg
      901 acaacaacag ccatccttgg ttcaatggaa cctttggtcg cagtggttgt aggcgtattg
      961 gtattttcgg aacatttcac attacaatca ttaatcggtt tattactgat actaatgtct
     1021 gttatcattg taatattagc cgatcaacaa aaaaagtcga agagaatcac agaacagaaa
     1081 atcattaagc cacattgagg aatagaactc acaattagtc tcagacaatt gtcttctacc
     1141 aatatcttta ttaaaagcgt aatgaaaagt cattagaagg aaagagaggg tatctgatta
     1201 gcatatctct gtcgccttcc agcaccttcc tgtattcagc gatacaatat acctatgggg
     1261 gacaaacgag aaaagtccga tcatgcgcac atgacgaggg tcaggagacc gatccgcaag
     1321 tagccgattc tgataatcat gaatatcgtg aaaatcatcg tcacaataac ggtcattctt
     1381 tctaagaatc tgtctccccc cttcataccc cgattaaatg tttatttctc acaacctttt
     1441 tattttgata ttttcaatcg ctttctactt tctttcttct tctcattctc tctcactact
     1501 tgcagcattt cattgatcaa ttcctctccg tcttgcgaat aaaaatactt tgtcttttcc
     1561 accctctcaa ccatatttcc ccatttatca tatttagaaa gtacaatacg tttagacgta
     1621 tccgaaagat aaacgcatct tacctctttc ccattcttat aataagtgct atcaatatcc
     1681 gtgcaatcgt ccagtacaat acgatcaacg tgaatatcaa aactatccga cttaaattcc
     1741 gtgaaactac ctgtgaactt catgtcagcg tcgaatataa attccttttt ccctttttcg
     1801 tcaacaatcg tcttgttaat agaactgaca ataccattct ttatacattt cctgataagg
     1861 gtgtctcctg ccattttctc tatatcgcac acgatgtcat agtcctcgtc tgtacgggga
     1921 atcctttttt tagcttcctc ataagatagt ccccgaaaga agtaagtggt tctttttttc
     1981 cctatgtcaa aatagtattg cactcttttt gttagattac cattcccgtc gtattcattt
     2041 ttttcctcat agtcgttgtc ttcatgcagt acatagtcat tgtttatatt tctaacatac
     2101 actaatttga gtttactttt atcgtaatat ttctgcaata aataatcaat ggtatcccct
     2161 tgagcattta atgttaacac ctcctccctt tggggagcat atcccataat cttgatattt
     2221 cccgacctct ttgactttct tcttaccgta aactcttcgt tgttgatata cgtataataa
     2281 tacgtgcttt tatcatcaat taaatcaatt gtttcagaat cttcttcata cctatgatga
     2341 gatgttctgg tcaattgtac ctctgacaaa cgattatttt catcatactt gttttcataa
     2401 gtcgtcatgg ttattcgatc ataagatttc tcttccgaaa ccgttttagt tccacacgca
     2461 tacagaacga agaccaaaaa caataatttt actttcattg tatatctttt tttagggcag
     2521 ggcagtgtcg gcaaatcaat agattttctt attaataact ccttcctgta aatcccgtat
     2581 cgttaatcgt tgatattctt gttttcttct catgaatgtc acatcagaat acgtattcaa
     2641 acttcctgcg tattcttcta ttagcctaat caaatctcta tttatttgta ttttcattta
     2701 aatcatcaac ttcaacagat cccattagtg tcaaagcaca ataaatttca tttttcacac
     2761 attcattaca taagggcaac ctatataaat cggcagattg ttgctttggt tgagacttac
     2821 ctaaacaact tatgacaaac aacatgcaac aaacaattct attgatttca taatacaaaa
     2881 ttagtgtata gtctttttgc ccgtctgtac agcctgcaaa cgttatttga ttattgttat
     2941 gttcttggct gcgatgacag gctaatcatg tttttcactt gtccaagcat aaatataaaa
     3001 agtcccgtaa aatcaagatt ttacgggact tacttttact tttccgtcat ttatctttga
     3061 cgctcagcgg agagacaggg attcgaaccc cgggtacctc gcagtacaac ggttttcaag
     3121 accgccgcaa tcgaccactc tgccacctct ccagaactac ggttaagtag tgcttttctc
     3181 ttaaagcgct gcaaaggtac gaatcatttt ttaacttgca aattattccg caaaaaaata
     3241 ttagaaaagt atatttgaaa gtaataaccg ccctctggct tctccccata aataggtatt
     3301 tttatgctat tcaacataaa ataggaccct tttatatacc taaaccgaaa aaaggttgta
     3361 aatttgcgcg ctctaaagga taactaacca ctaactgatt aattttatgg aactgaataa
     3421 gacctttaaa gatggacttt ggagcaaaga aatcaatgta agggatttcg ttagtaacaa
     3481 catcactcct tatgaagggg atgcttcttt cctgcaagga cctaccgaac gcaccaaagc
     3541 tgtctggaat cactgtctca aagctctcga agaagagaga aacaataatg gtattcgtgc
     3601 actcgactac acaactgtat ctactataac ctctcaccct gccggctaca tcgataaaga
     3661 gaacgaactg atcgtcggac tacagaccga tcaggtgtta aaacgtgcca tcaaaccgtt
     3721 tggcggaatc aatgtggtta tgaaagcttg ccgtgaaaac ggagtggaag tagatgacag
     3781 agttaaggat atcttcactc actatcgcaa gactcacaat gatggggtat tcgatgtgta
     3841 taccgaagaa attcgttcgt tccgttcatt gggattcctt accggacttc ccgacaacta
     3901 tgcacgcgga cgtatcatcg gtgattatcg ccgcctggct ctctatggtc ttgaccgtct
     3961 gatagaagct aaaaaagaag atctgcataa tctgacaggt cctatgactg aagcccgcat
     4021 tcgtcttcgt gaagaagtag ccgagcaaat caaggccctg aaagagatta aagtattggg
     4081 cgaatattat ggtttggatc tgagccgacc ggcatatacc gcacaggaag ctgtacaatg
     4141 ggtgtatatg gcttatctgg ctgccgtaaa agagcaggat ggtgctgcca tgtcactggg
     4201 taatgtatct tcattcctcg acatctatct tgaatatgaa ttaagccagg gtacgataac
     4261 cgaaacattc gctcaggaac tgatcgacca attcgttatc aaactccgta tggtacgcca
     4321 cttgcgtatg cagtcgtaca acgatatttt tgcgggtgat cccacatggg tgaccgaatc
     4381 tatcggtgga cgtttcaatg acggacgtac caaagttact aaaacttctt tccgcttctt
     4441 gcagacactt tataacttag gcccgtcacc ggaacctaac atgactgtac tatggagccc
     4501 tgagttaccc gaaggtttca aagcattctg tgcacaagta tctatcgaca cttcttccgt
     4561 acaatacgaa aacgacgacc tgatgcgtga agtccgtcaa tcggatgact acggaatcgc
     4621 ttgttgtgtt tcatatcagg aaatcggaaa gcagattcag ttcttcggcg cacgtgccaa
     4681 ccttgccaaa gccctgctac tggctatcaa cggaggacgt tgcgaaaata caggtacagt
     4741 tatggtaaaa gacatccctg tattgaccgg tgaaacactg aagttcgaag aagtaatggc
     4801 caactataag aaagtattga tacaaattgc acgtgtatac aacgaagcaa tgaatatcat
     4861 acattacatg cacgataagt attactacga aaaggcgcag atggctttcg tggatactga
     4921 tccccgcatt aacctcgctt atggtgtagc cggactttca atcgccatcg attcactgtc
     4981 cgccatcaaa tatgcacatg tgaaagcccg tcgcaacgac atcggactga cggagggatt
     5041 cgatatcgaa ggtgctttcc cttgtttcgg taatgacgat gaccgtgtag accacctggg
     5101 tgtggacctg gtatatttct ttagcgaaga attaaagaaa ctccccgtat ataagaatgc
     5161 ccgtcctacc ctctcgctgc tgactatcac ttcgaacgta atgtatggca agaagaccgg
     5221 tgccactcct gacggacgcg ccaaaggcat tgcctttgct cccggtgcca accccatgca
     5281 cggacgtgat aaaaatggtg caatcgcctc actgagttct gtagccaagt tgcgttatcg
     5341 cgactcacag gatggtatca gcaatacatt ctcaatcgtt cccaaatcat tgggagcaac
     5401 acaagaagac cgtatcgaca atctggtgac catgatggac ggatacttta caaaaggcgc
     5461 acaccacctg aacgtaaacg tgctgaaccg ggaaatgttg caggatgcga tggaacatcc
     5521 cgaaaagtat ccgcaactga ctatccgtgt ctcaggatat gccgttaatt tcgtgaaatt
     5581 gagccgcgaa catcagttgg aagtaatcag ccgcagtttc cacgaaagaa tgtaattgaa
     5641 tgataaacgt acactcatac gagtcaatgg gaacattcga cgggccgggt ctccggctcg
     5701 tcgttttcct tcaagggtgt aacttccgtt gcctctattg tgccaatccg gacacaattg
     5761 aagccaaagg agggacagca accgaccctg aggaaatagt tcgcatggcc gtcagtcaga
     5821 aagctttctt cggtaaaaag ggaggtatca ccttttccgg cggagagcct acttttcaag
     5881 ctaaatcgct tatcccactt tttaaaagac taaaggaaaa aggaatccat atttgccttg
     5941 ataccaatgg cgggctatgg aacaatgatg tagaggaact attggaattg actgatctgg
     6001 ttttattaga tatcaaagaa tttaatccgg aacatcatca gtctttaacc ggaagaagca
     6061 acgagcagac cctgaaaacc gcagcctggc ttgaaaccaa tcataaacca ttctggttgc
     6121 gatatgtatt agtgcccggc tacagtgact tcgaagacga tatccggcaa ctgggagagc
     6181 atcttggaac gtaccagatg attcagcgtg tagaaatatt gccttaccac accttgggtg
     6241 ttcacaaata tgaagcaatg aacaaagaat atatgctgaa aggagtgaaa gagaatactc
     6301 cggagcagat agaaaaggct gagaaactat tcaggcaata cttccggacc gtacaagtga
     6361 attgacttat ataagtgtcg aaattcgtat tcgccacaga ttacacgaat ttacacagat
     6421 aaagattcat tggcaatcaa cagattaagt tcactctgcg gtgaattatg acgattgcgc
     6481 ttatttataa ttttgtaagt cacgacataa aaatctccct gttcttgcct caattcatta
     6541 caatacaagg caagaacagg gagataatgt aaccggcata ttttttgcca tcctacttta
     6601 ataagtgaat cgcaatcctg cctgcaagtt aaagttacaa ggcctttctt ttcggatggt
     6661 ttgtactttg gagccatcat caaagaaata cgaaactccc ggttccacat ataggccgac
     6721 atgatctgtc gcattgaatt gcgctcccac ggcaccggct acagaaaatt gcaaaggctt
     6781 cacattcacc ttatcatccg ccaactttcc ataaacacac ttttcaacca ttcctccggc
     6841 agatacatag agtgtaaaat atttcttttc cagaaaattc cagtttccac gtacaggaat
     6901 acctatataa tgcaatttct gactctgcat cttggtatcc ccctgccgtt tgatgtcaga
     6961 agacaacaac gtataagtca atcccgtctc tacagagaaa cctttgggaa gagacttacg
     7021 tacagacagt ccgaagctaa ccggctgatg atgttcataa tccaccacgg cagttgtatt
     7081 ggacttcagg taagggactc cttcttcaaa tataacttcc tgatcggcag gaatactcac
     7141 agctccattc atgatcgtca tcaagtcgac cctgttagtc atcggacggg gcgcaaaatt
     7201 ttcggaacca tttgtcggaa gtccacctcc attaccgata cccactccca tcgaccattt
     7261 accaccacgt ttagcagaag agtctccgat aggcaactga tacttgtctt taccggacgg
     7321 tcgccgcgct tctttcctct ttggaggctg cgccgtcgca ctttcttttt tctcgattgc
     7381 agcaattgct tcctgttgcg gctcagatct cttttcctcc gtcactgcct ccggtcgctt
     7441 ctctaccagg gaggatacct ccggaacaat caccggatca gtattctttg ccaaatagcc
     7501 cgaaacaggg ttaatactcg tcgttcctac cggcttaact ggttcggata cagctacctg
     7561 tacatctggc aaggcaggtt ccggcaatac atccgggttg acagccagtg aaggagccgt
     7621 tgcataacgg atttcatcag ctaccggact attcagaaaa tacaaactga cagcagtcgt
     7681 taccaccaat accacagctg ccgcagcaac cgcccaccgg cgatacggat atattcgttt
     7741 ttcggttaca ggcatcagtt ccctttccag tcgttcccaa ccggaagcag gcatcggctc
     7801 cgaataatct tcgagcttat ccttgaatgc tttaatccat ttttcgtctt ctttcatcat
     7861 tctatttcat ttttgaaatc caaggttcac ctcagtatct gtaaatacat gtcaaccatt
     7921 ggtcaccaac cattctttca ctttctttgc caatacactt tttgcgcgaa aaagctgtga
     7981 ggcagaagat ttttcattaa tccccaacat ctgtgcgatt tccttgtgcg acttatcttc
     8041 aaaggtgtat aaattgaata cggtacgata tccggcgggg agttcattaa taaattgcat
     8101 cagcactttc tgtggtattg cttcaacagc cgaagcatcc ggttcttcat acgtttcggg
     8161 aacttcatcc agtgccgtgg tctggttcat cacgtcgttc tttcttaaga actgtaaaac
     8221 cgtattcacc attacacgct ccatccatgc tctcagagag ccttcacccc gccaggtaaa
     8281 cttgtcgaag gagtcgaaaa tcttcaggaa accgtcgtgt accaagtctt gtgccatgtc
     8341 cctgtctccg gcataacgaa gacagacacc aagcatgcgc cctgcgtact gctcataaag
     8401 ttctttgcgg gcacgattat ctccctgcct gcaacgttcc gacagctcta attcattcat
     8461 tctcctaaac acgtgtttac cttataaatg cagcaaagat agaaatactg cacagagaga
     8521 acaactcttt tatcactttt gtttctttaa cattttagga tgcaatattt catcacttcc
     8581 tgcattttct caatacaata aagaataaat ctcaatggat aaataggata aaaccaacaa
     8641 gaaacttatg aagaaattta atttaataac ttttgccgtc atcctgatgt tattgcccat
     8701 tttacagtca tgtctggacg atgccaacaa cgacgagtgg gtcacttgtc ctccgggtgg
     8761 aatattggcc atcggcacaa tgaagattcc caatgcggac actccaaggg actttttcat
     8821 tgcattggac aatggagaca atgtacttcc ggcagatacg gccgatatac gcaacaggaa
     8881 atacactgtt gcagaaggtc aaagagtctt cgttggctat ctgcagatgg gagaagagaa
     8941 acctggatat gagaacggta aaatattcac gatagaagat atattgacga aagagatcat
     9001 cccactgacg gaagctacag cagacagcat tggagacgac cgtatcaacg tcacagcgca
     9061 tgcacttacg aaagattatc tgaccatcga atatcaatat ctgggcagca tgaatgaaaa
     9121 taaaaaacac atgctgaact tggtacaaaa cgaaataaca ggtcccataa aagatgacgg
     9181 atatatctat ctggagttcc ggcataatgc ctttaatgac tcccccaatc aattgggttc
     9241 gagccttgtt tctttcaagc tggatagtat agccgagcaa ttggcgacag ccaaaggaat
     9301 aaaactccgt gtgaacacca tttatgacaa tatacagtat gtcacaatag atatcaacga
     9361 agacaaaaac ttaaaaataa aatcatttca ttctcaataa aacaacaaga aacacctaca
     9421 caatcaggca aaacgagtaa taattctgat acataaaaga aataaggcgg cgatgtttgt
     9481 gaaaatatcg ccgtcgtttt tatattatac cagacactga acggcctgca gggtaagcat
     9541 ctccttggga accgccgcct gaatctcctc tttcaaaacc tgcagcagac tggtgcggat
     9601 gaagtctttc cgggtcacca ggacaatctg acgggtaggc cgcgggatag caaacggacg
     9661 gaccagttct ttctgctctt cgctcaattg catcactgcc agttcaggaa taaacgtaat
     9721 ccccttacca ctctccacca tatgcataaa ggtttccata ctacccagcc gatacgccat
     9781 ttggctgatc ttaaccgctt ccatctgaca aaaacgaacc aactgatcgc ggaagcaatg
     9841 cccttcgtca agaagccaaa gccgttcccc tgtcacatcg gacgtacgaa tcacatcgtg
     9901 cttgaacaac ggttccttct ttgagacata gcccaggaat tgctcgtaaa ataaggtctc
     9961 ttccgttaat gcggcatcat ccagcatgct ggcaatgata gcagcatccg cttcaccggt
    10021 cagcagagcc ttgcgaatgt cgggcgtctt catctccatc acccgtatat caagatccgg
    10081 gtatttctcc atcagttgcg gaaagaaacg gggcagaaga taaggtgcaa tcgtcggtaa
    10141 cactgccaat cggaatgtac ccgacaggga gtgctgttct tcgctgatga tctccttgac
    10201 acagataact tccgaaagaa tcttacgggc ctgttccagc actttcttac caatggcagt
    10261 agggcaaacc ggtgtcatgc tacggtcgaa cagtttcacc cccaattcgt cttccagctt
    10321 ctggatcatt gcactcaaag taggttgcgt cacccggcaa tactcggcag ctttagcaaa
    10381 atgccggaac tggtccacag ccagaatata ttccaattgt tgtatagtca tcgttctctg
    10441 atttattaaa gatatagaat ctatcaatgc aaagatagaa attttcagtt tgacacgaat
    10501 cattttgtgc cgtatctttg ttccagataa aaagaagaaa tatagtatta actcaaaaaa
    10561 aacaatatca ttatgaagac tttaaattat acacatttgg aagaaaaagg agctaacacc
    10621 atcgtactgt cattacagca actgcttgcc gattttcaga ttcattatgc aaacctgaga
    10681 ggatttcact ggaacatcaa aggacacggt ttcttcgtac tgcacagcaa gtttgaagat
    10741 ttatataatg gagccgccga aaaggtggac gaaatagccg aacgtatatt gatgctggga
    10801 ggaactcccg ccaataaata cagtgactat ctgaagatgg cgcagatcaa ggaagtggac
    10861 ggagtgaata aggccgacga cgctctgaat catattctcg aaacttacgg gcatctgatt
    10921 gcggaagaac gtaaaatcct gtctctcgcc tcttcacaca acgacgaagt aacagtggcc
    10981 atgatgagcg actacctgaa agaacaggaa aagatggttt ggatgctgac tgcatacaac
    11041 ggataacagc cgaaagggtg tagccatctg accgaaaagg tgtagccata caaacaaaag
    11101 ggtgtagcca tcccggcggg atagctacac ccttcctgtt ttattcgatt cagatgatac
    11161 ttgtacgttt ggtaaattca ataatctccg gaatgtatcc gaatgcgagc ccggtcactg
    11221 tatccgcaca cccataatag atggcaatcc gtccggtctc cgaatcatga agcgccgcgc
    11281 atgggaaaca gacattaggc acatcaccca tacattcgta atccttctga ggtgaaatca
    11341 gataaggccc cgaacggaat tttactttcc agggctgatc gatgtcaagc agtgccgaac
    11401 caaaactata cacaaaaccg ttgcaggaag ccaatacacc atgatagatc agtaaccagc
    11461 cttccgaggt ttcaatcggg ataggccctg caccgatctt ggtacactgc caggcactgt
    11521 cttcgaacgg agccggcgac ataacatgac gatgacgtcc ccaaaactcc atatcgggag
    11581 actcgctata gaaaatatct ccaaaaggag tatgcccatt atcactcggg cggctcaaca
    11641 tcgcaaaacg accgtttatc ttacgaggga acaagactcc attccgattg aagggaataa
    11701 aggcattctc caactggtga aaagtaacaa aatcataggt gtaggccaca ccgatagtag
    11761 gaccatgata gccattacac caggtcacat agtagcggtc ttcgataaag caaacccgtg
    11821 ggtcatatcc atagacccag gttccaacct cagcgtcatc acattgaaac tttaacggtt
    11881 cttcgttgat atcccaatga acagcatcct tgctgaatcc cacatgcaaa cgcatgcgac
    11941 gattagtatc atcacaacgg aacacccctg catagccatc cttaaacgga actacggcac
    12001 tgttgaatat actgtttgaa gtagggagca agtcgcgcgg aataatcgga ttggccgaac
    12061 aacgccacac tacatcttta catcctgccg gacgttcttc ccaaggcata gccggcaaag
    12121 cagcacctgc aattttaatt tcttccatga ttcgattaaa ttaatattat gtatatatct
    12181 tgtttatatt gaaaatctct ttttatttct tctttccgtc cggatatgtg aaaggtacca
    12241 gccaagtcac gataaaagcc ggtatggtag cgataagtac ccagataaag aaatcgcgat
    12301 aacccagcca atcgctcagg tatccgctca tcattccggg aagcatcacc cccagattca
    12361 taataccggt agcaaaagca taatgtgcca tctgatgttt gccgggagcc acttgctgca
    12421 tcataaagag catcaatccg acaaaaccaa acccgtaacc caagtattca gacacaatgg
    12481 ccataccaat aatccataga tcggaaggct ggtaaagggc taacaggaaa tataccaaga
    12541 acggaatatt aaaagcgcaa cataaagaaa acaaagtctt ccgaagtccg aaagccgaaa
    12601 tgtaataacc ggccaaaagc gaaccgagaa taaaagctcc cgctccgaac gtaccatata
    12661 ccagtccgat atcctgagtg ctgagtccca atccaccatc cgcaaccgac gctttcagga
    12721 acaacggtac aatcttgatg gcatatcctt cggcaaaccg gtacaaaatg ataaagacaa
    12781 tgtagaaagc aatatgtttt ttttggaaaa aagagcggat gacttcccaa agcatattca
    12841 atgcgtcact catcgtattc acttcaccgg aagctcctcc tcccgaaggc aaaatccgga
    12901 tgtggtaaag accgatcaga atcataatac ccgcacacat caacatgaca atcatccagg
    12961 catgtaccac tccaaattca tccttcagca tacctgccag ccaaaccaag cctccgttgg
    13021 caagtatctt ggctagatta taaaaagctc cctgccaacc gatatacttg gcttgctggg
    13081 tagcagtcag ttcagtcagg tatactccgt cacccgcaat gtcatgagtc gcaccactga
    13141 gagcaatgat ccccatcaga gcgatggcat aacgaaaaaa gtcgggcagc ggcagcgaaa
    13201 gtgctaccaa tgcaaatgcc agtccggtaa tgatttccgt agcgacaaca aagtattttt
    13261 tcgttttaaa catttccaga aacggactcc ataaaggctt caatgtccag ggaagcataa
    13321 tgagagaagt ccagaaagca atctgtgcat tcgacacttc catatcggaa aacataagga
    13381 cagaaaccat cgaaagggcc acaaacggca atcccatagc aaagtaaaca gtaggcaccc
    13441 aacatacagg gcttatcggc tttttattca tcagttagtt ttttataata attccatcgg
    13501 ttaacaattc cagtaagcaa agatagggga tattaaaaac ataacccaag attacgacaa
    13561 gaagttgctt tcattattta ataatacaac tcacccggga aaactactaa cctctatcac
    13621 ccttttttta ttaaacttta tcaatacgac acacgcaaag aagcaccgaa gactttcatc
    13681 cccgatgcct ctcgccccct tatctacaat ctaaacacct ctattgcttc acatataaat
    13741 ttatctcagc aaacccggta taattatccg gagtcagaca gtttattctg aattccttta
    13801 cattcgggat aggtggttcg atggccgcat attgcggatc agccccttta aaatttctga
    13861 aagtcaagac tctcgggtaa gtaacccact cggtttcacc ctctttccga accttaatct
    13921 cagcacttct cagattataa cccgatccgt aggcactctg tttagtgacc gaaaatccgg
    13981 ttaaggtaac aggccggtcc agtaccgtat tccaccaaca ctctccggca ttagccactc
    14041 cccatgtaaa ccaagtagta tttatctcac cgtcaatagc cagatgtgca ccatatttgg
    14101 catcatcatc ggcataaaca ttgctgcaac ttacactcca cgcacttcga tctacagcgg
    14161 accaattccc gggtttcgta taactggtat aaagcacgct ggtataaatc cggatataaa
    14221 ccgtcttcat agatgtactg acagcctgtt cgtccatgcc cgtaactcct ttaagcgtca
    14281 cgggaagcac atatccgcca ggattagtca acttttctat attcttcaaa acgacctgaa
    14341 aagatgaatc ggccactgtc tgtcccgttt ttaagacaac ttcacttgtt tcaatggtat
    14401 aattatcttg gggcaacaac ttacatttcg tcttattggc agaattgtaa gtatccactt
    14461 tcagcgtatc tactcccaaa gcggcagtga catcccgcgt aaccggctgt acggcacaca
    14521 attgtatttc aaaatcagaa cggtcggcag tagaggaatt gctcacacaa tccaccacta
    14581 ccgcagcacc catttcggcc cccggtgcaa ctcccgttct gatatatatc ttttgatatt
    14641 tgtccatttc atcatcatcg ttgctgcacg aagccaacga tacaaagcct gttatcaggc
    14701 agattaaggt cacaaaattc aaatgtctat tcatatctta tcttcttttt acatagttat
    14761 tgcttatcaa aacgaacatg ctctttccag acaagagttc ctcctgccac caaatcgtat
    14821 ccgtgtccgg tacagtcggc aaaggcattt cccttacctt catccatttt ccaatagcct
    14881 atcaggttcg gatcggcggg tttcacggca aaatacatgt tggactgaat ttgcgtctgg
    14941 ctgattgcgc tcttccaaag acgcacctgg gccatctgac aattgttgcg gaagtaacta
    15001 ccgctcgaaa ccatgttcat cttgtcgaat ctaaccgggc caccctttgt ctgcagagtc
    15061 acgtcgagca ctccgttgat ataaatcgac aataacccgg aagaattata aacgaaggcc
    15121 agatgatacc acttattctt ctcaaacaaa gtcactgtat tgacctgact tccaagtgtc
    15181 ttcacctgta atgaattata agggatcata gcgtcaccga aacggatata aacctcgtgg
    15241 tcgctgctgc ccgaattaaa tatagcctga ttattaatat cgaatccgtc catctgtacc
    15301 caagcctcga gtgaccattc attggttgtc actccccaca attcgtcctt ggcgggcttc
    15361 acggcattgg tcgtattcat aaacggtaca gactgtatca gcggcttatc cagcaaaatg
    15421 atgaacttcg acgaaagccc gattgtggac accggtccct gaatttctgt gagagatacc
    15481 ggaatagcat acaattctcc gttttcgttt gaataaggtt tcactctaaa ctcactgggg
    15541 attgcgctaa catcgcctgc cgctatcttt atctctttgt cataagtaaa atactgctcg
    15601 ggaaggactt cgtacgaagt ttcattagct tcattgtact ctttaagaat agaaggatct
    15661 accgtcagga cagcagtcac attttcggtt acaggctgtc ccacacgtac ggtcagagta
    15721 gttgttgtta cattttcagg atcaacggta acctttgccg aaccattctc ggatgcttca
    15781 ttcaaataaa tcgcattgtc gataacctgg taatcggcat cgttgcatcc tgccaggatc
    15841 atcgacagaa cgaaacaggc aagcaaatat tgttttattg ttattctttt cataatcaaa
    15901 ttctttaaag tcattttaca gcaggattca ttattctgat tgcttcacgc aggtacttat
    15961 attcgatgtc gcccggatag tcatattcca tgtgataggt gcctactccc cccttccgta
    16021 cctgttttcc gtcaatagtc ggagtccagc gtgccatgcc ggcaagtgct ctcattttgt
    16081 ttccataacg atctacataa tcacctcctc ctgtcggagc ataagattcg aaattctccg
    16141 taacgatgta catattagcc actttctccg gaggaagtat tcctttaaag ttggcaatcg
    16201 taccagccag acgtctgtca agattagcat cggaattacc cgcaaggtta gagtatgcct
    16261 gcacaatgaa atagtcaaag taaggcccgg tttccggatg aatactttga ggctcgccat
    16321 caatcacaag taaccgtccc gtacccgatt taggtccgat tcttt
//
