LOCUS       gnlProkkaGKLAJMFB_357  13848 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GKLAJMFB_357.
ACCESSION   gnlProkkaGKLAJMFB_357
VERSION     gnlProkkaGKLAJMFB_357
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 07:06:05
            Original ID  :: gnl|Prokka|GKLAJMFB_357
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13848
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..552)
                     /locus_tag="ctg357_1"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SDSCIELIIYGTHGNEKEICKLTKPDIKDLSYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTQKNNTLTY
                     YECSKFEVDINHPFTGTEFKT"
     protocluster    1..13848
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[10502:12932]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10503..12932
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13848
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13848
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             900..2069
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 219.1; E-value: 2.2e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg357_2"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             2088..2393
                     /locus_tag="ctg357_3"
                     /transl_table=11
                     /translation="MEKYEIHFIGSVLDSNTSGDEQAKIVALIEQGHSVALDLSGCSYV
                     SSAGLRVMLYAFKLAKAKSRDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             2408..2836
                     /locus_tag="ctg357_4"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             2833..4434
                     /locus_tag="ctg357_5"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     ARAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCINHEIQPYFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLTNERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFMGDEQGRLYRVPISPDHMAAVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             4431..7268
                     /locus_tag="ctg357_6"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGVPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYNRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTDSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILTPVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLAFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPCIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             7291..8127
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 140.9; E-value: 1.2e-42)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg357_7"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMSPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             8124..10490
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 167.8; E-value: 9.2e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg357_8"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHKN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             10503..12932
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 2.3e-83.
                     Score: 271.9. Matches aSDomain:
                     nrpspksdomains_ctg357_9_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg357_9_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     260.2; E-value: 4.9e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg357_9"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-88, bitscore:
                     286.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPAGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRQEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAVGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEESYRIFRTEYDNCERLWNKYYPNAPVLRLPTDHWHFLEGESLEQLITVFLK"
     aSDomain        10539..11705
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg357_9_AMP-binding.1"
                     /evalue="2.30E-83"
                     /label="ctg357_9_AMP-binding.1"
                     /locus_tag="ctg357_9"
                     /protein_end="401"
                     /protein_start="12"
                     /score="271.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPAGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     aSModule        10539..12206
                     /complete
                     /domains="nrpspksdomains_ctg357_9_AMP-binding.1"
                     /domains="nrpspksdomains_ctg357_9_PP-binding.1"
                     /locus_tags="ctg357_9"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10731..10772
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg357_9_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg357_9"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS_motif       10953..11009
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg357_9_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg357_9"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       11511..11597
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg357_9_0003"
                     /evalue="1.20E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg357_9"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.3"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       11670..11732
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg357_9_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg357_9"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        12030..12206
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg357_9_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg357_9_PP-binding.1"
                     /locus_tag="ctg357_9"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     CDS             12937..13830
                     /locus_tag="ctg357_10"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGIISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKPEREMN"
ORIGIN
        1 agtcttaaat tcagttccgg taaaagggtg attaatatct acttcgaatt tgctacattc
       61 gtagtaagtt aaagtgttat tcttttgagt atagatagct ggaacgattc catccgacca
      121 tacttttaat ccttccttat tgccatttat ccaccgttca taggtgtctt tacctgtttt
      181 agtttcgatg ctgtttactt ggcagatacc tacatgacat aatatgattc catcatctgt
      241 taacatctct ttgaaatgtg gaatatggca ggcgctatgg caagcatcaa gaactaatct
      301 acaaactttt cctttgaaga aatagctcag atcttttatg tctggtttgg ttagtttgca
      361 aatttccttt tcatttccgt gtgttccgta aataattaac tctatacagc tatcgctatt
      421 aatagatttt gtgttcaaat ccagagtttt tttcagtaca ctataatctt tgtatcggat
      481 ttctaaagag tttgttgtac atgtcgtttg tgcaacttga caactatcat cttgttttaa
      541 aataataagc ataatagtga ttcgtaaaaa gttcctactc tttcttcggc ttttcggaat
      601 ccgccgtttc tatttattct ttgtaagctt acggtgacaa aagtgagaag aaaagttcca
      661 tcttaaaaat ataatttctg aatacggaat agtttctttc aggagtgtaa atcaatcttt
      721 caggtgctgt cttctaagcc acgaaagcaa tatacctgta tgcttataag acaatatcgt
      781 ccattcggaa aaacattctt cctgtttaaa atataaaatt gtaaccgggt cggtcacgct
      841 ctatttttgc catcataaac gtcagaacaa acggttgaaa ttcataaata acaatagata
      901 tggcagtaaa aatattgagt gtagatgatg aactcgattt agaagtatta cttacccaat
      961 acttcaggcg acaaatacga aaaggtgaat acgagttcgc ttttgcccat aacgggttgg
     1021 aagctttaca gaaacttctg gaaactcccg atttcgatat catcctgagt gatattaata
     1081 tgccggagat ggatgggttg accctattgg ctaaggtcaa tgaactgaaa aatccggcaa
     1141 tgaagtgtat aatggtctct gcttatggag acatggataa catacgttct gccatgaaca
     1201 agggagcgtt tgattttgca accaaaccga tcgatttgga tgatctgtcg cggactattg
     1261 aaaaggcgat cgaacaggtt cgctatatcc gtgagtcaca gcaggagcac aaccaactgg
     1321 aatctatcaa aaatgacctg gctattgcgg gagaaatcca gcaaacgatt cttccccgtt
     1381 cctttcctcc ttttccggaa ctgacggaag tggttgatat ttatgcttcc atgactccgg
     1441 caaaagatgt aggtggcgat ttttatgatt tcttccagat tgacgatgaa cgtatcgggc
     1501 tggtgattgc tgacgtatcc gggaaagggg tgccggcatc cttgttcatg gcggttagtc
     1561 ggaccctgct ccgtgcaact gctcttcggg gtgtttcgtc ggcagaatgc cttacttatg
     1621 ccaataagtt actgtgtaaa gagagcctgg actctatgtt tgttacggtc ttttatggga
     1681 tttatcatta taaaaccggc atgatggact ataccaatgc cgggcataat cccccttatc
     1741 tccttcgcgg cggacggact gttgaatgct tgcctgtcgc ttctaatttt gtggtaggcg
     1801 tgttcgatga tattgaattt gagagtaata cattgacgtt cggcatcggt gacactttac
     1861 ttctgtatac ggatggtgtc acagaggctt ttaacgacaa gcgggaacaa ttctcggaaa
     1921 gtaacttaca ggatatattg gcgtctatgc acgaaagtag ttccgcaaaa gaggttgtta
     1981 cgagtgtatt gcagtctgtt aagactttct ccggagacta tcctcagtcc gatgacataa
     2041 ccctgctttc tcttcaacga atcaaataat attaaaataa aagaacgatg gaaaagtatg
     2101 aaattcattt tataggttcc gtcttggatt caaatacaag cggtgacgaa caagcaaaaa
     2161 ttgtagctct tatcgagcaa ggacattctg ttgcattaga tctcagcggc tgttcttatg
     2221 tatccagtgc cggattgaga gtcatgcttt atgcctttaa gctggcgaaa gctaaaagta
     2281 gagatgtttg ccttgtcggt gtgtcacaag aggttaaaga cgtgatgcac atgaccggat
     2341 tcgataaatt ctttcgtttt tatcagactc tcgatgaatt atcacaaccc taaaaattac
     2401 ctgagcaatg acgttacttc agtttcgccc tgtcgatggg aggttagatg aaattcttag
     2461 tatgctgatg catagtcgtg aagttgcttc acatccttcc ctgtcttatg ccatccgttt
     2521 ggtcagtgag gagatcattg tcaatattct caattacgct tatccgcagc aggcagaagg
     2581 ttatctgact ctgtgcttat gggatgaaga cggagagatt actttggagt ttatagatgg
     2641 tggtattcca ttcaatcctt tggataaagc cgatcctgat atttcattac cgttagaaca
     2701 acgtgaaata ggaggattgg gcattttcct ggtacgtgaa atgatggatg acgtagcgta
     2761 tacgtacgtg aataaggaga atcggttgac cattaaaaag aaatatctgc aacccactga
     2821 tgaacctgta tcatgatcaa gttaaacgaa aatataatcc gttggatcat tgccgttcct
     2881 tgtatacttt tgacagtatg tctggtccta taccgggcat atcgtcattc ggcatcggac
     2941 agggagcgtc ttgctctgtc tctggaggaa ttccgggata aagaaaagaa atcggttctt
     3001 atacaacggg tcagtcaaca aatggaggag attgcttatc aacaaaagga tatttccgaa
     3061 aagagaagac aggaagccgt tgcgcaaact caaaaggcca accgaatgca acagcaggca
     3121 gagttggcac gggaaagagc gcttgctgca caattggagg ctgagaaagc gtatcggatg
     3181 gcagatgaac aaaagaatct ggcgatggaa cggcaactac aggccgaaca gtcgaagagg
     3241 gttgccgata cattggcttt tctggctttg ggacgttcat tggggacact ctctgttact
     3301 caatatcggt cgggcaacat ggaattagct tctctgttgg catataccgc ctggtggttt
     3361 accaagcgat atgatggcga tgtatatcat ccggctgttt tcaatgcatt gtctttgtct
     3421 tgtaggcaag atcagctttg gttcgggcat aaaggagctg ttaccgggat caaactgtta
     3481 tccggaggcg aggaaaaagc aagagccggt cggaatcctc tgccgggatt ggtcactgtc
     3541 ggcaagtacg gtgagatgat acgttggaaa tcggaaaatg ggcagaccta tacctccgaa
     3601 ttactgttga atgatccctg ttatgatttt cgggatgtgc tgttgcggtc cgattcacag
     3661 atgtatgcct tgtcatactg cgggcagctt atctccacgg attccgccgg tatcgttacc
     3721 cgctttttgc ctaaaggaga atatcggcaa ttgatttcga ttgcctctaa cttggtattg
     3781 gcagtttcca caaccggtat ttattctttt gactgtatca accatgagat acaaccttat
     3841 tttcagccgg aacattcgat aacttgtgtc ggtcaaatgg aaggctatct ctatgttttt
     3901 tttaagaatg ggacagtagc tttactttcg tcggatggta catttctcag atttatagac
     3961 agcttgcccg agaatagtgt ggttactgca ttctgtcctc ttaccaatga aagatatgcc
     4021 attggctgtc gtgaaggagt catcctgatt tgtgataaga atggaaatat ccggcagaag
     4081 ttgatagggc atcaggctgc ggttactgct atttcccgga aagggaacaa actgttttcg
     4141 agtagttacg attgtacgct gcgtctgtgg gatcttcgta aaggaaagac cgagtcggct
     4201 gttattgtga caagccccgg ttggattcat actttttgct ttcatccgga cggtacatct
     4261 gtctttatgg gagacgaaca ggggcggttg tatcgggtgc ctatttcacc cgatcacatg
     4321 gctgctgttg tccgtcaggg gttacagcgt gattttactc gagaagaatg ggagtattat
     4381 atcggtaagc aaattccatt tgaatcctat tacctaaaaa cgtatcagcc atgaaaaaga
     4441 tagtcttttt gataatgtgt ctttgctcgg tatatgcaaa ttcacaagag ggtgtcccgt
     4501 tttttgtaaa ctatccggct tcggtttatc aggcgcataa tcgtaatttc gatgtcgttt
     4561 gcgacagttg tggaaatgtc tattttgcta atttcgaagg tatccttcat tatgactata
     4621 accgttggga aactatttat acaccgggct tttcccgtgt cacccgtttg tttcgtgatt
     4681 cggaaggtag gatatgggtg ggaggatata acgtgttcgg acggatagag cgtgatggac
     4741 gcggatgtat tacgttgaga acccttcttt ccgatctgga cacagactct ttgggcgaat
     4801 tggaagatat ggcagaaata gataaacgca tttatctgaa agctacatca ggaagatatt
     4861 atacggttca gtcagattcc attttgacac cggttcaggt acttccggcc caattgcagg
     4921 aaaagtggag aaatcaatcc tcagtctcaa tgaatcgggc gttttctcta cccggaggag
     4981 aaacaatctc gataaactct gcccatggat taataatgga tgacagtggg aaaaaagaac
     5041 ggttttccgt aactgagaga aatggcttat gcagtaacgc tgtttcgggt attgcggccg
     5101 atgggcgtgg caatctctgg ggagctacgg ataacggtgt gtttcatgtt tttattccct
     5161 ctttgttcag ccgttatacc tctggtgaag gtctgaaggg agaggtaata tcggctgtct
     5221 cttacaaagg aatgatatat accgggacct tacagggatt atacgtattg aagcaaaaca
     5281 cttttgttcc tgttcaggga atttcgcaag catgttggca actgtgtctt tctccacaag
     5341 gagaattata tgcagcgtcc ggcgatggtg tgtatgtgat ccgggattat aatcattcgg
     5401 aaaaactcac agatatggca gcttattcat tggcattcat tgggcatacg aaccttctga
     5461 tgggcactat ggatgggatt tatcaatatt cggcagatga ggaacggata aagaaaattt
     5521 ccgatgtcga aaaagtcgtt cgtctggaag tgaagaaaga tcgttctgta tgggctaaaa
     5581 cgttgtacgg agaaatctat ttgcgggaag agggcgaaag ctcttttgta cttcaagaca
     5641 gagagagtga agaagtaatg accgagtata cggacaacga tggctgtcat tggcagacaa
     5701 atctgaaagg aaaagaggta caggtacatc attcgcaaat tgatacggag aaattcaacc
     5761 aatgcctgta tgccattcgg aattatgtcg tgagggtgat ttatattgaa gaagacaggg
     5821 cggcatggtt cggcggtgat tttggtttaa ttcggatgga ccttgaaaag gcccggacat
     5881 ttactccggt tgctccctgc atctatcttc gtgaagtttg tctgaaccgt gattctgtct
     5941 attggggagg agatctgccg gaagagtccg ggggagcgga ctggcagata aatagtacag
     6001 tacctcgttt ggggaatgat gtacgttcca ttcgtttttc atttgctacc gatgcgccct
     6061 gtttcaccgg ttccaatgag tatagatatc gcctggtcgg ttatgatccg gaatggagtt
     6121 cgtgggattc cgggactgtg aaagagtatg ccaacctttc gtcgggtacg tatacgtttt
     6181 gtgtccgggc ccgtgatatt tacggcacag agagtgaaat gaaacaattc cgcttttcgt
     6241 tattgcctcc tttttatttg caatggtatt gtctgatcct atataccgtt gcttttggaa
     6301 tgctgttgtt cttattgttt aaatggagaa tgcgcagttt gctgaaagag aaggagaggt
     6361 tagaggccct tgtcggccaa cgtaccaaac agttggtaca acaaaaaaat gaaattgagg
     6421 aaaagtcctt aaaattggaa aaagcattga aggagctggg ccaggcacaa gatgaattgg
     6481 ttcgacaaga aaaaatggct actgtaggta aactgactca agggttgatt gaccgtattc
     6541 tgaatccgtt gaattacatt aataattttt cccacctgac ctcaggatta ctgaaggacc
     6601 tatatcagaa tctggagagt gtaaaagaac ttttggatga agatacctac ttggattcgg
     6661 tagatgtcat caacatgatg agagataatc tggaaaagat tgaggaacat ggaagtaaca
     6721 ccactcgtgt actgaaggcc atggaagaaa tcctgagaga ccgtaacagg caactggaaa
     6781 aaacagaatt aatcggttta tgccggaaag acatggagct attgagcagt tattatcaga
     6841 aggagattac ggctatgcac attgcggttc gtacttcctt gcccgataat ccgttgttta
     6901 ttgacgggaa tgccgaacaa ctgggaaaaa ccattatgag tcttcttaac aatggtatgt
     6961 atgccatagc caaaaaatac ggtaagaaag cctatccggc agagattggc ctggcattgg
     7021 aaagtaagga cggacaggca gtcattcgcc tatatgacaa tggagtgggg atcgagcaga
     7081 gtattctgga taaaatcttc gatccgttct ttactaccaa aacaaccgga gaggcagcag
     7141 gtatcggttt gtatctgagt aaggaaatca tattaaatca ccatgggcag atagcagtac
     7201 gttctgaaaa agatgaattg acagaattca ctatcactct gccattgtgg gaggaaaagt
     7261 cagtataaat aaacatagaa cagattgatt atggaaaaaa acatttcaca agagaaacga
     7321 attgaagagt tggaagcacg gctcaaagag caggaaaagc tgggatcatt gggtttgttg
     7381 agtgcaggca ttgcacacga gatacagaat cctttgaatt ttgtcatcaa tttcagtaaa
     7441 ctgtccggtc aattgttggc cgacctggcc gatagggtgg atgaagcaaa agctcgtatt
     7501 ccggaagcgg aactggaaga tatcaaagat atactttccg ggctgagaga gaatgtggac
     7561 aaaatcaaag agcatggtga tcgggctatc agcattatcc gtggtatttt gctttactcc
     7621 agggggaaag aagacgaatt catgcctaca caaatacaaa aattgactaa agaatatgtg
     7681 tggctggctt atcatgccat gcgggccaat tataagaatt tcaatattgc tatccgtgaa
     7741 gattatgcta aagatatccc ctcgatccgg ctgatcccgc aggatttcag tcgggcagtc
     7801 ttgaatgtga tgaataatgc ctgctatgca gtatggaaaa aatggcagaa tgctcccgaa
     7861 ggatattccc ccgagataat ggtgacctta gaaaagttgg ataaaagaat tgtactttct
     7921 attcgtgata acggagaggg catgagtccg gaggtcaaac gaaaactatt tgactctttt
     7981 ttcacaacaa aaccggtggg gcaggggaca ggccttggta tggcaatcgt tcgtgatatt
     8041 atagaaaaca aacaccatgg aaaagtattg tttgattcgg tcctgcatga atatacttgt
     8101 ttccggttta tcattcctat cgcatgaaac gctgtctgct atatatcctt tgctgttttg
     8161 gggttgtgca actgtcagct cagccggcgg ataacatccg taattcgttt gtaaaggcgg
     8221 aaacatttta taagagcgga gatatcgatg aagcttgtcg tatcttggag gagaatctgt
     8281 cgtcttttca aggtacgatg cataccgagg cgtgtcgttt ggctgcatta tgctgtttag
     8341 ctttagaccg cttcccggaa gcggaaaagt atgtttcgct gttattgaaa gacgaacctt
     8401 attattatat ctcgcttcaa gatccggaac ggtttgcgga tatggtaagg aaacacaggg
     8461 agactaaagt aactctggtc acagcctcac aacaggtaga gaccccggaa gaagctccgg
     8521 tgcctgttac tttaattacg gaggagatga tacgggctat ccatgcccgg tgcctgcggg
     8581 atgtactgat agcttatgtg cccggtatat ccggtttgtc ttccaatgaa gagatgaatc
     8641 tggctatgcg cggggtatat tctcccgaac aggagaacat attgattatg caggatggac
     8701 aacgtctgaa cagttatatt actaatgctg tttcgccgga ttatggtatt agtctggcaa
     8761 aagtcaaaca aatagaggtg ctgcgcggac cggcttcttc gctttatggc agtgtggctt
     8821 tgacagccgt gattaatata gttactaaag acggggtgga tgttcgtaat ggttccatat
     8881 ctgtcagtgc cggtaatcgg ggccagttgg ctgctgacct gctattggga aagcacgaca
     8941 tgaacatgga ctttatggca tggttctcct tgtaccgtgc aacgggagaa tcggtttttg
     9001 tcccggccga aaaacaatat gctctttacc ctagggacgg attcatccgt ctggacaatt
     9061 attcgggatt tcctgccatg gatggaggaa ttaaattgca acgtggaaat ttgcttttta
     9121 gtttcagtat gaattacgcg aagaaaaggc aaccttatag catgtggctc ttttcttctc
     9181 catattctta tgagcggttt cgtacttttg acggttccgg cccgggatat tccaggtggt
     9241 cggcaagaga acaggctgtt tatagccgca cgtggcagcg gatcactttc agtaccgcat
     9301 tttataccga ttggaataaa aacgtacatt atgaaacctc gggagatact ttacaagact
     9361 atcctatttt tcctaactat gattatcaac ctattattta tccgactcgc ggagcatttc
     9421 aatacatccg ctggatggat tttaacgtag gctttaatgg gcgtgtaaac tatgcctatg
     9481 attgggggaa gctggggaaa ggcaatatgc ttggcggtgt ggaatggaat cggtatacgc
     9541 tttatgattc cgagtatttg gaaggtatga attttaaaga gatcgtcagg acgtggatcg
     9601 aaaaacgact ttacacggga cacgagatga acacggatgc ctttcttcag attaaacaca
     9661 acctgcataa aaattggatt gtcaatgccg gcatcaggta tgactataaa cggcgaagta
     9721 ataagcggac attacaggct ttttctcccc gtctgtcact aatttatctc aggaacggat
     9781 taaatatcaa agccagttat tccagagcat ttgtcgatgc gccctattat tacagaaaca
     9841 atgaaatgga tacctattcg ggtggcgaaa atctgcaagc tgaatatcta agttcatatc
     9901 aggtgacttg tgcttatcat cattcacctt cacatataga tgtagagtgt aatttatttt
     9961 ataatcgggc gtcccatttc ctgttcacac agccggaaac acgtgtttat gaaaatgccg
    10021 gttctctgga tatgggaggt gtcgaggttg ttgcccgtta taaggcagac cgactgagcc
    10081 tggatggaaa cctgtgtttt cagaaagtat tgaattatac caattttttt gttaccgatg
    10141 gatctgtgaa taacgtaccc ggcttttcta tgaatcttgt agcaaactac tttttactta
    10201 aaaagaaagt acagagctgg tctgcccatt taaaattgaa ttgcagtagc cactgctaca
    10261 ctcaggtaag tgtattggaa gatggactca atggagatgc gacgaattac acagtccgtt
    10321 tgcccggtta tgctgtcttt tctttcacta ccagatataa gtataaaagg atagaaggca
    10381 gtctgggcat tgagaatctt ttcaataacc gatatgaatg cggaggagcg actgttccta
    10441 tccgccagaa aggaaggtgg atttccgcca gtatattgta taatttctaa atcaaactaa
    10501 taatgaaaac aaacattcaa gaaaatcttt ctcgatcact ctctacctgg ggtgacaaac
    10561 cggcggtcgt tgcaaaagac ggtaccgtct cttatcaaat gctggaacgt tactctgcca
    10621 atatagcaca atctatccgt caacgtttat cggtaactga tccgtccgga cttcggaata
    10681 tctgtatcgg agtttgtatg gaacgaaaca aaactttagt acctgccatt ctggctattt
    10741 tccggttagg ggcaacttat ttaccgatag atccctcgct gccggataat cgtaaacggt
    10801 atatggctga aaatgcggat atggttttgt tgttgaccga ttcatcgaat gaagtaggtg
    10861 gaattccgtc cgtccgccaa ctttacctga atggggagca actatccgaa ccggttgttg
    10921 gtgactatac tgaagttctt cccgatgatt gcgcctatat tatatatact tccggaacaa
    10981 caggcaatcc taaaggtgta cgtattagtt atcggaatct ggatacattt acgaggaatc
    11041 tgatagataa gaaattgtat catttgtctg atccggcaaa caggtacctg gcgtttgcga
    11101 gtatcagttt tgatgcttcc atattagaac tgatgatgtg tattccggcc ggaggaacat
    11161 tgatcctggc cggtgaggac gaacgcagag atatttcttt actagacgaa ctgatcaggc
    11221 gcgagaaggt gaatattgct ttttttcctc cttcgttgct gggcatgttt gccgaccttg
    11281 actttccatc ctttaagact ctgctctttg gtgcggaggc tattggtgaa aagttattta
    11341 acaggctgaa acagcagcct taccggttga tgaatgtata tggaccgaca gagaataccg
    11401 tactcagtac catacggatt gtaggcaaag atacgtcgta tgacgatatt ggctatccgc
    11461 tcaagggaac tgtctgttat gttttgtctg aaaacctcca acagacaact cttggggcta
    11521 caggagaact ttgcttggga ggacctcagg tttcgctggg atatattggg agtgttcagc
    11581 tgaatgaaaa atcattcatc tcgtacgatg gagaacggtt gtacaggaca ggtgacctgg
    11641 tacagcagca accggacggt tcgatacggt ttatcgggcg aaaagatact caggtcaaga
    11701 tacgtggttt tcgtatcgaa ttgactgaaa tagcagaacg attgaataga gatccggacg
    11761 tggagagagc ccacgtagta gttgttgagc ggaatgggcg tcaattattg ggagcttatt
    11821 tgcaaccctc agtctccggt aactttcatc cggaagaggt caaagagcgt ttgcgtgcag
    11881 aacttcctta ctacatgata cccaatttat ggcaggtggt agatcatttt cagcgtacta
    11941 taaatgataa gattgatgtc cgggcgctcc cggcttttac ttcattggag ttgaagtatg
    12001 ttcctcctgt tcatccgggg gaggttatct tatgtggaat tttgaaggaa atgttaggtt
    12061 tgcctcaagt cagtgttgag gccgatttga ttgatgatct gggattaact tcgctggata
    12121 tgttgaggct tgttaccgag gccaataaaa aaggatgtcc catcaacgta tctgcagttt
    12181 atactgcccg taatctgcgc cgattattgc tcgttccgcg gcaagaacct atctattggt
    12241 acaggcagca aaacctgaag aaacccgtaa tcattctggt ttgtggatct gcctatttta
    12301 atcatttgta ctttaatttg gccgaccgcc tttatcccaa atatgacttt ctagttgtag
    12361 atgctatcta cgatcatttt aataaagtgg ccacggatat tccggaactg ttggaatatt
    12421 atgtccggac ggttcagcca atgatccggg agcgtaccgt ctatgcgctt accggctttt
    12481 gtatgggagc tgaactggct gtcggcctgg ccgaaatgtt acatcgctcc atggggataa
    12541 tgccaaaagt ttttgctctg gatggacagg cttggcaaaa tccggctctc tgtcaaaatt
    12601 atcctttgtt ggtatttccc ggagatacag atgaaatggt acgtgaacgg aacgaaatca
    12661 taaatattta ttttcgaacc actcctaatc tgatttatca gggagaggtt attgttttgc
    12721 tgtccggatt gttccatcaa caggcgggat tgtctcctga agagtcgtgg acggaggaaa
    12781 gctatcgtat attccggaca gaatatgaca attgcgaaag attatggaat aaatattatc
    12841 cgaacgctcc tgttttgcga ttgccgacag atcattggca ctttttagaa ggggaatcat
    12901 tggaacaatt aataactgtg tttttgaagt agatttatgc agactgaaaa cttcacttta
    12961 ggtaagaaag agcttcttat tttgcttggc ttgactcttg tactgccttt tccaatcaat
    13021 tgggcattaa tcgaactgaa tccgttgact ctgatggcgg gtgcagacga tgtgcccacc
    13081 tggattggtt tcggcggcag ttatattgga ggaatcatcg gagggatcat ctcgattatg
    13141 attctgaaca agacacttca gcagacaggt gtacttcatc acgatttgaa actcctgcag
    13201 ttagatacca taatttatac tcagcaacaa gattggttta ccggtttcaa acaagaactg
    13261 gcagagaatc tcaaatctat tgatttgtat gtgttgaata cggttgtttc gtctatatcc
    13321 atgaaaaact atgcatatgc caaagaggtg ttgacagaaa tcaataaagg gctcgaatat
    13381 cagatggttg ccgcatcctt ttctttcact tctacgcatt tatcatccga agaaaaaaag
    13441 tatatgaatc tggtacgccg cgtacagact gaatatagct cttttatcaa ggatattctt
    13501 tactatattc ctttggcaga aacgatatct tccaggaaaa aactaaacta tgatcagctg
    13561 atggactata ctttgtccca atatgattat ttgcaaggtc aggaagggga gtctacagct
    13621 tcgggagcca tcataccgcg tgttatggaa atcgatccat ctgatgatat acggaaagaa
    13681 ctagaacgga taatggaaga aagattaacc gggcgtacct atttgtatca cctgaagtca
    13741 gatcttgcag aggctacgca tcaattaatt atttatgaag agaaccgtat aaactctatt
    13801 ctgcataaac ctgagagaga aatgaattga catatattaa tataatat
//
