LOCUS       c00279_gnlPro..        14885 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GKLAJMFB_279.
ACCESSION   c00279_gnlPro..
VERSION     c00279_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 13:04:49
            Original ID  :: gnl|Prokka|GKLAJMFB_279
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14885
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14885
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[246:4885]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      247..4885
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14885
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14885
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             247..651
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg279_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 8.3e-24, bitscore:
                     75.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDTKIELLEPTCPESTIAKFIENKGAGVHHVAFAIEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             777..2330
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg279_2"
                     /sec_met_domain="CT_Btheta (E-value: 7.9e-291, bitscore:
                     955.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIELRAQARLGGGEKAIEKQHAKGKYTARERIAQL
                     LDEGSFEELDMFVQHRCTNFGQEKKHFLGDGVVTGYGTIEGRLVYVFAQDFTVFGGSLS
                     ETMAQKICKVMDMAMKMGAPVIGINDSGGARIQEGINALSGYAEIFQRNIMASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMTEGTSYMFLTGPAVVKTVTGEDVSQEDLGGASVHAS
                     KSGVTHFTAETGEEGLAIIRKLLSFIPQNNLEEAPLVNCTDPIDRMDDLLNEIIPDSPN
                     KPYDMYEVIGAIIDNGEFLEVQKDYAKNLIIGFARMNGQSVGVVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVAVLYAKEAKDQENPAQFLA
                     DKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             2351..3265
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg279_3"
                     /sec_met_domain="OAD_gamma (E-value: 4.9e-16, bitscore:
                     50.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKRIGIFIALLAMVCMGLRAQSATSLRINEVLVVNDQNYQDDY
                     GLHNAWIEIFNTSFASVNLEGCFLTNDKNNPTKYPIPKGDVLTLIKPRQHALFWADGMP
                     NRGTFHVNFTLDPNKENYIALYDSNGKTLIDEVTIPAGQLADRSYAREKDGSANWVVKG
                     EGEHSYVTPSTNNMTIDKNPKIENFKKHDSIGIGMAIIAMSVVFIGLVLLYLSFKAVGN
                     VAVRLGKKNAMKATGITDKTEAKEKNLGSHTGEETAAIAMALHEYLNDAHDVEDMILTI
                     NKVKRTYSPWSSKIYTLRQTPKR"
     CDS             3291..3722
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 70; E-value:
                     3.8e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg279_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.4e-22, bitscore:
                     70.0, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQYKYKINGNLYNVTVNDVEDNIANVEVNGTSYKVELDKPVKAA
                     PKPVTRPAAAPKTETGAPVVTKQPTASKKDGVKSPLPGVILDIKVKEGDTVKKGQTIII
                     LEAMKMENNINANKDGKVAEIKVNKGDSVLEGTDLVIIE"
     CDS             3725..4885
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg279_5"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-153, bitscore:
                     502.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFVSFLGNNLVDFWGYTGFANATPGHLFMLLIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALLIGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRALTTKHERLIRMKPPRIVSHTEKVIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASQFLTWDSILIFILGAFSFIIATASGVMFVKFFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             5034..6365
                     /locus_tag="ctg279_6"
                     /transl_table=11
                     /translation="MRTRTMKPLFLIFCLCLSPLLMGQNQNKIQEAMANYDYETAVELI
                     NKEPPTIPLLMQKAKALKGIGSNAEALRSIRQVIAEDSTNQQAHIEAAECCKAMAKYND
                     ALDYYRKAISLNPKNKYARLQFINLLCNTKNYAEAFGESSMMSETDSSAVVLHLQAQSL
                     EGMQQILPAIGCYEVIQDKYPDDYLAAAKLGNLNIVAGYPEYAIQATERYRERDSTNLI
                     VNQQNALAYCHAEQYPTAIKRYEKLCQQGDSSTQTLYYLGVSYYADEYYYEAHACFSKL
                     QKEMEENPNLLYYLGRCCAKTSWKKEGIEHLEKAIELTIPKDSTMIRLYKGLVDCCKLA
                     QDTPKQIQALRELYKYDKTNHKLLYDIAWNYSYQLKDNKSAERYLQAFLKTRKANARKE
                     EPVSEKGELVLGLENYYNAAENWLKDLQKEKFFKEGIPLESQKQ"
     CDS             6379..7671
                     /locus_tag="ctg279_7"
                     /transl_table=11
                     /translation="MKHWILLLYLGFSVMLRAQNTASVQEAMANYDYKTVIRLIDEESA
                     SPQLLIQKAKALKGLGRTAEALSTLQHIIIELPENQQALVEAAECCRQLSKFNEALGYY
                     RKVMELNPEHIYAHLQYTRLLYNYQRYGDALRESIALARKDSSATVLRLMAESMEGAGM
                     PVESMFCYLSIIRKYPSDYLSVAKLGSIFNTMKDYEGAIALTEAYRRTDSTNVEVNRQN
                     ALAYCLRKEYPTAIKRYQDLTARGDSTLLTCYYLGVSYYATKEYYKARDWLLKAKSCQS
                     PGANLLYYLGRSCSKTLWKQEGIGYLNQAIALTIPADSIMERLYSGLADCYRQTKQTRD
                     QIKATKEQYKYVPDKHILLYNLAFLSDKIGDTKATEHYLQAFLRTKSKQNAVLQQPDDD
                     EEEPAPYIDYYKSATNKLESIRKEKFLKGEK"
     CDS             8197..10047
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg279_8"
                     /sec_met_domain="Alpha-amylase (E-value: 6.5e-63, bitscore:
                     204.6, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLLLLGSFLLSLTTYAAMNISKIDPPCWFTGMNNPELQLMVY
                     GEGIGQASVSVNYPGVSLSSIVKLESNNYLLVYLHLDKEVKPGKMPITFTVGKKKLVKE
                     YELKARSKAGVDHKGFDASDALYLLMPDRFANGNPDNDRIEGMAEYKVDRNDPNARHGG
                     DLAGIEQNLDYFTDLGVTALWFTPVLENNMKGGSYHGYATTDYYKVDPRFGTNEEYRSL
                     IAKAHNQGIKVVMDMIFNHCGVEHPWIKDMPSKDWFNHADFKNNFVQTSYKLTPHVDPY
                     ASEYDFDQMNNGWFVEAMPDLNQKNPHVYKYLLQNSLWWIEYADIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPRNSHLKTVMDFSFFDKV
                     NTAKNEQTDTWFKGLDRVYNNFVYDYLYPNPASVLAFIENHDTDRFLGEGENLDMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTDDKENALTPEGRTRLQNE
                     SYNFYRNLLNWRKGNDVIAKGSMKQFMVQHGVYAYARQYKGKTVFVLLNGTDKEVKLPL
                     KYYAEVLKDKTQGKDVISGKVTALNEELTMAPRQSMVIEL"
     CDS             10205..10645
                     /locus_tag="ctg279_9"
                     /transl_table=11
                     /translation="MTNNESERELVLQTLRTWMAFRQAVQRVLKRHNVDMTFEMLQVMN
                     CLWNKQGISQQSLAEKTAKDKACLTNLINNLEKKNWVIRKEGPSDRRNRLIFLTPQGEE
                     LALTVKPLINDIYAQTGTEMEASRITECIEDLKRLHEVLNEI"
     CDS             10658..11725
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg279_10"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 8.5e-12,
                     bitscore: 36.2, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTHQIKLKQLRRLKFRNIFLNTVCILLALAGISWTVNYFWKYAR
                     YEITNDAVVDQYIAPLNIRIPGYIKEVRFTEHQYVHAGDTLLILDDREYRIRLKDAEAA
                     LMDALGSKEVLNSGIRTSGVNVAVQEANIAETLARLSQQEAELNRYTRLLKKQAVSQQD
                     YELAKANFEATRARYNALLRQKEAAQSQYSETSKRSTGAEANILRKEADLEMARLNLSY
                     TVVTAPYDGYTGRRTLEPGQFVQGGQTLSYLVRGNDKWVTANYKETQIAHIYIGQKVRI
                     KVDAFSGRTFHGTVTAISEATGSKYSLVPTDNSAGNFVKVQQRIPVRIDLNDASPEEME
                     CLRAGMMVETEAVRP"
     CDS             11730..13325
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg279_11"
                     /sec_met_domain="MFS_1 (E-value: 2.7e-14, bitscore: 44.1,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKLNLPTRPWVPQWLGIVTMFIVIFPITLLNGAYTGSMVEVSNT
                     LGVLSEDITMAYYSASVGMAVAYPIVPKIRTIATPKTLLLTDLLLQIFFSLVCAKTGSM
                     DVIMVCSFCMGFLKAFVMLEFIILIRPLFSPKNVRSEFYAYFYPIVFSGGQLSMAITAQ
                     LAYHYQWQHMYYFVTILLLIAILFVICFFRYARRPMHIPFKEMDGRSMFIIATAFLLTL
                     YTFTYGKTLDWFASPKIRVYVFVIPLLIALFIHRQRTQGKPFVSLKPLFLHKSIIGYSF
                     MVLAMFLTATSSLVTNYMNSIIRVDSIHANSLSLWLLPGYVVGAVICFWWFRWQRWRFR
                     FLISGGMFCYVIYLAILYFGITPYGTYEMLYLPILFRGVGMMVIFIAFGVFVVEDLDPR
                     LTLSNAFFLISFRSVLAPVLSASFFNNMLYYLQAKGMNILSENMTLTNPLAEQKYNQAL
                     SNALAQGHEFGEAGQLAANSLYSTLQQQSLLLALKTLIGYVLILALVIAVIAAFIPFHK
                     TLKVAVVKTGDDMV"
     CDS             complement(13420..14424)
                     /locus_tag="ctg279_12"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKNPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYDENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTEPDEVVDFVTKTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFDVLDGV
                     MKELPGFPIVLHGSSSVPEEEVATINQFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKVFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAE"
ORIGIN
        1 aaatatacgt ctgaacatcc gcctgtctca gggatcagcg ccaaccctct ccgcctttta
       61 aaccacctcc cttaggtttt aaaccaacga tacctgcctt ttaaacccat gcaccttagg
      121 ttttaaacct attttcacca taattaattg cagaaaaatt tctttattaa acaagaattg
      181 attttctttg tgctgtttta taccattccg aaaagacgat taataccaaa atttaaaaat
      241 atagttatga agatttcaca cattgaacat ttgggcattg ccgtaaaaag tatcgaagaa
      301 gcccttccgt attatgaaaa cgttttaggt ttgaaatgct acaacatcga aactgtagaa
      361 gatcaaaaag taagaacagc cttcctgaaa gtaggtgata ccaaaatcga attactggaa
      421 cccacatgtc cggaaagtac catcgcgaaa ttcattgaaa acaaaggtgc aggtgttcat
      481 cacgtagcat tcgccattga agacggcgta gccaatgccc tggccgaagc cgaaagcaaa
      541 gagatccgcc tgatcgacaa agctccgcgc aaaggtgccg aaggcctgaa cattgctttc
      601 cttcacccga aatcaactct gggcgtactg acagaactct gcgaacacta aaaagatgta
      661 cgattcggac gatccgcgcc acggacaaac ggaatttttc tttgcattaa attccccatc
      721 cgggttgtca atcgtcctgt tgtaaatatt ataacccttt aaattaagaa aaactcatga
      781 gtaaccagct tgaaaaagta aaagagctta ttgaacttcg tgctcaggct cgtttaggtg
      841 gtggcgaaaa ggctattgaa aaacaacacg ccaaaggcaa atatacagcc cgcgagcgta
      901 ttgcacagtt gcttgacgaa ggtagtttcg aagaactgga tatgtttgtt caacacagat
      961 gtactaattt cggacaagag aaaaaacatt tcctcggcga cggtgtggta accggttatg
     1021 gaacgataga aggtagatta gtatatgttt tcgcacaaga tttcacagta ttcggtggtt
     1081 cactgtcgga aaccatggca caaaagatct gtaaagtaat ggatatggcc atgaagatgg
     1141 gtgcccctgt tatcggtatc aacgactcgg gtggcgcacg tattcaggaa ggcatcaacg
     1201 ccctgtccgg ttatgctgaa atcttccagc gcaacatcat ggcttcgggt gtcatcccac
     1261 agatttcagg tattttcggt ccgtgtgccg gcggtgcggt ttactctccc gccctgacgg
     1321 acttcacgct gatgacggaa ggtacatctt acatgttcct caccggaccg gctgttgtga
     1381 aaacagtaac gggtgaagac gtgtctcagg aagatctggg tggtgcaagc gtacatgcca
     1441 gcaagtccgg tgtaactcac ttcactgccg aaaccggtga agaaggtctg gcgattattc
     1501 gcaagcttct cagctttatt ccgcaaaaca acctggaaga agctccattg gtgaactgta
     1561 ccgaccccat cgaccgtatg gacgacctgc tgaacgagat catccccgac agcccgaaca
     1621 aaccgtacga tatgtacgaa gtgatcggcg ccatcatcga taacggagaa ttcctggaag
     1681 tacagaaaga ctatgcgaaa aatcttatta tcggttttgc ccgtatgaac ggacaatcgg
     1741 taggtgtggt tgccaatcag cctaaatacc tcgccggagt actcgacagc aatgcttcac
     1801 gcaaaggtgc acgcttcgtt cgcttctgcg acgcattcaa cattccgctg gtgacattgg
     1861 tagacgttcc gggattcctt ccgggtacgg gtcaggaata taatggtgta atccttcacg
     1921 gagccaagtt gctgtacgct tatggtgaag ccactgtgcc caaggtaact gttaccctgc
     1981 gtaaatctta cggtggttcg cacatcgtaa tgagttgcaa gcaactccgc ggcgacatga
     2041 actatgcatg gccgacagcc gaaatcgccg taatgggcgg tgccggtgca gtagcggtat
     2101 tgtatgccaa agaagccaaa gatcaggaaa accctgctca attcctggca gacaaggaag
     2161 ccgagtacac taaactgttc gccaacccgt acaatgcagc caaatacggt tacatcgacg
     2221 atgttatcga accgagaaac actcgtttcc gcgtgatccg cgccctgcaa cagctgcaga
     2281 ccaaaaaatt aaccaaccct gctaaaaagc acggtaatat tccattgtaa caaattaaac
     2341 atcgattgtt atgaataaga aaagaatcgg gatatttatc gctctgctgg caatggtttg
     2401 catggggctc agggcgcaaa gtgccaccag tctgagaatc aatgaggttt tggtcgtcaa
     2461 cgaccagaac tatcaggatg actacggact gcacaatgcg tggatagaga tattcaacac
     2521 ctctttcgct tctgtaaatc tggaaggttg ctttctgacg aacgataaaa acaatccgac
     2581 caaatatcct attcccaaag gcgacgtgct gactctgatc aagccgcgcc aacatgcttt
     2641 gttctgggca gacggaatgc ctaaccgggg tacgttccac gtgaacttta cgctcgaccc
     2701 gaacaaagag aattacattg ctttgtatga ctctaacggt aaaactctga ttgacgaagt
     2761 aaccataccc gccggtcagc ttgccgaccg ttcatacgct cgcgaaaaag acggaagtgc
     2821 caactgggta gtaaaaggtg aaggagaaca cagctatgtc actccgagca ccaacaatat
     2881 gactatcgac aaaaacccga agatcgagaa cttcaagaaa cacgactcta tcggtatcgg
     2941 tatggccatc atcgccatgt cggtcgtatt cataggtttg gtactcttgt atctttcatt
     3001 caaggcggta ggtaacgtag ctgtcagact gggtaagaaa aacgcgatga aagccaccgg
     3061 tatcaccgac aagacggaag cgaaggaaaa gaacctgggt agccacacag gtgaagaaac
     3121 cgccgcgatc gccatggctt tgcatgaata cctgaatgac gctcacgacg ttgaagacat
     3181 gattttgacc atcaacaaag tgaaacgcac ctactccccc tggagttcga agatctacac
     3241 actgcgtcag actccgaaaa gataattact aaccctaata aaatgaagca atgaaacaat
     3301 ataaatataa aatcaacggc aacctttaca acgttacagt gaacgatgta gaagataaca
     3361 tagccaacgt tgaagtgaac ggaacctctt ataaagtaga gttggacaag cccgtcaaag
     3421 ccgctccgaa accggtgacc cgtccggcag ccgctccgaa aacggaaaca ggtgctccgg
     3481 tagtaaccaa acaaccgaca gcttccaaaa aagacggtgt gaaatctccg cttccgggcg
     3541 ttatcctcga cataaaagtg aaagaagggg ataccgtgaa gaaaggccag acgatcatca
     3601 tccttgaggc tatgaagatg gaaaacaaca tcaatgccaa taaagacgga aaagtagcag
     3661 aaattaaagt taataaagga gattctgtac ttgaaggtac agacctcgta atcattgaat
     3721 aattatggga gatttcgtat cattcttagg gaataacctt gttgacttct ggggatacac
     3781 cggttttgcg aacgcgacac ccggacatct tttcatgttg ctaatcggtc tcttctttat
     3841 ctaccttgcc gtagccaaag aatttgaacc gatgctgctg atccccattg gcttcggtat
     3901 tctgatcggt aatattccat tcaatatgga agccggatta aaagtgggta tttacgaaga
     3961 aggttcggta ctgaacatcc tttatcaagg agtaacctcc ggctggtatc cgccgctcat
     4021 tttcctgggt atcggagcca tgacggactt ctcggcgctg atctccaacc ccaaattgat
     4081 gctgatcgga gctgccgcgc aattcggtat cttcggcgcg tatatcattg ccctgctcat
     4141 tgggttcgaa cccaaccagg cgggtgctat cggtatcatt ggcggtgccg acggaccgac
     4201 ggccatcttc ctttcgtcca aactggctcc caacctgatg ggtgccatcg ctgtgtcagc
     4261 ctattcttac atggcactgg tgccggtgat acagccacct atcatgcgtg cgctaaccac
     4321 caaacacgag cgtctgatcc gcatgaaacc accgagaatc gtatcgcata cggaaaaagt
     4381 aatcttcccc atcgtgggtc tgttgcttac atgcttcctg gttccttcgg gtctgccttt
     4441 gctgggtatg ctgttcttcg gtaatcttct gaaagaaagt ggagtaaccc gtcgtttggc
     4501 aaatacggcc agtggtccgt tgatcgatgt gatcactatc ctgttgggac tgactgtggg
     4561 agcttctacc caagcttcac aattcctcac ctgggattct atcttgatct ttatcctcgg
     4621 tgcattctct ttcatcatcg caacagcgtc aggtgtcatg tttgtcaaat tcttcaatct
     4681 attcttgaag aaaggcaata agatcaatcc gctgatcggt aatgcaggtg tatccgccgt
     4741 acccgactcg gcacgtattt cacaggtaat cggtttggaa tatgatccga ccaactatct
     4801 gctgatgcac gccatgggtc ctaacgtagc gggggttatc ggttcggctg tagctgccgg
     4861 tatcctgctc ggattcctca tgtaaacgat atttttttca ttagtaaggt agacgtcctt
     4921 cttttcgcaa agaagggcgt cttttttttg cgttaatcta tctaaaagac attacgaacc
     4981 tttcgtagaa tggatatttt tactaacttg cggacaataa aacaatacgt cctatgagaa
     5041 caagaacaat gaaaccactc ttccttattt tctgtctttg cctcagtccc ctactgatgg
     5101 gccagaatca aaacaaaatt caggaagcaa tggcaaacta tgactacgag actgccgttg
     5161 aactgataaa caaggaacct cccaccatcc cactgttaat gcagaaagca aaagccctga
     5221 aaggaatcgg cagcaatgcg gaagctctac gttccatccg ccaagtgata gcggaagact
     5281 ccaccaacca acaggcacac atcgaagcag cggaatgctg taaagcaatg gccaagtaca
     5341 acgatgcgct ggactactac cggaaagcca tcagcctgaa tcccaaaaac aagtatgccc
     5401 gtttgcaatt catcaaccta ctttgcaaca ccaaaaacta tgctgaggct tttggagaaa
     5461 gttcaatgat gtccgaaacg gacagttcgg ccgtagtgct ccacctacag gctcaaagcc
     5521 ttgaagggat gcaacagata ctaccggcta tcggttgcta tgaagtcatt caggataaat
     5581 atccggacga ttatctggct gcggccaaac tcggaaacct gaacattgtg gctggatatc
     5641 ccgaatatgc catccaagct accgaacgct atagggaacg ggactccacc aacctgattg
     5701 tcaaccagca aaacgctctc gcctactgcc acgccgaaca atatccgaca gccatcaagc
     5761 gctatgaaaa gctgtgccaa cagggggaca gcagtacaca gaccttatac tatctgggag
     5821 tcagctatta cgcggatgaa tattattacg aagcgcacgc gtgtttcagc aaactgcaaa
     5881 aagagatgga agaaaatccc aatctgctct attatctggg acgttgctgc gccaagactt
     5941 cctggaaaaa agaaggcatc gaacacctgg agaaagctat cgaactgacc attcccaaag
     6001 acagcaccat gatccgactt tacaaaggct tggtggattg ttgtaaactg gctcaggata
     6061 ctccaaagca aatccaggct ctcagagaac tgtacaaata tgacaagacg aaccataaac
     6121 ttctttatga catcgcctgg aactattcat atcaactcaa agacaacaaa tcggccgaac
     6181 gttatctgca ggctttctta aaaacccgaa aggcgaatgc caggaaagaa gaaccggtga
     6241 gtgagaaagg ggaacttgta ctcggacttg aaaattatta caacgctgcc gaaaattggc
     6301 tgaaagactt acagaaagaa aagttcttca aagaaggaat accgttagaa agtcagaaac
     6361 aatagaatct gtccccccat gaaacattgg atactcctcc tctatctggg cttcagcgta
     6421 atgctgcgag ctcagaacac cgcctccgtt caagaagcaa tggcaaacta tgactataaa
     6481 acggtgatca gactgattga tgaagaaagt gcatcaccac agttactcat acagaaagcc
     6541 aaagctttaa aaggtttagg gcgtaccgcc gaagccctgt ctactttgca acatatcatt
     6601 atcgagctgc ccgaaaatca gcaggcattg gtagaggcag cagaatgttg caggcaattg
     6661 agcaagttta acgaggcctt ggggtattat cggaaggtga tggaacttaa tcccgaacat
     6721 atttacgcac acttgcaata cacccgcttg ttatacaact atcagcgata cggcgatgca
     6781 ttgcgtgaga gtatcgcatt ggccaggaaa gacagttccg ccaccgtatt gcgactgatg
     6841 gcggaaagca tggaaggagc cggcatgccg gtagaaagta tgttttgcta tctttccatc
     6901 atcaggaaat atccctccga ctatctctcg gtagctaagc tgggcagtat cttcaataca
     6961 atgaaagatt acgaaggggc aattgccctg acagaggcat accgccggac ggacagcacc
     7021 aatgtagaag tgaaccgtca aaacgcactg gcgtattgtc tgcgcaaaga atatcccacc
     7081 gccatcaaac gttatcagga tctgaccgcc cggggagaca gcacactgct gacatgttat
     7141 tacctgggag tcagctacta cgcaacgaaa gaatactata aagcgcgcga ttggctgctc
     7201 aaagcaaaat catgccagtc acccggcgcc aacctactct actatttggg acgttcgtgc
     7261 tccaagacat tatggaaaca agagggaata ggatatctga accaggctat cgccctgact
     7321 atccccgccg acagtatcat ggagcgctta tactcaggct tggcagactg ctacaggcaa
     7381 accaagcaaa cccgggacca aatcaaggct accaaagaac aatacaaata tgtccctgac
     7441 aagcatattt tactttataa cttggcgttc ttatcggaca aaataggaga tactaaagcc
     7501 acagagcatt acttgcaggc ttttctgcga acaaaatcca aacaaaatgc agtactacag
     7561 cagccggatg atgacgaaga agaacccgca ccctacatag attactacaa aagtgccacc
     7621 aataaattgg aaagcatccg aaaagagaaa ttcttaaagg gagaaaagtg aattgatcgg
     7681 atagatgcat cgtttcggac aattcaccac tgagtgcaga cagagtttca cagagggaga
     7741 ataatggaaa ataaatttga agatgtgcgg tagaaggcac agtagcacgt aaccgaagtc
     7801 acatcggcac gcagccgaaa ttacggtgct gtgtagctaa agttactgtg ctgcgtagcc
     7861 gaagttacgg tgctgcgtaa ccaaagttac ggtgctgcgt agataaagtt acggtgctgc
     7921 gtagccgaag ttacggtgct gcgtagataa agttacggtg ctgcgtagcc gaagttacgg
     7981 tgctgcgtag ccgaagctat gacggcatct ccttttccgg acgtcacgtt cacctgattg
     8041 catcgaaaag tgctccttat cggttgagct ccatcccgga gaattctcca atgaaaacgt
     8101 ttgcataaat agatggcaca cagtaagaaa gaaaacggaa aacaatccga tgatttaccc
     8161 tatattagca acattaaata ataacgagct aatatcatga aaaaattatt gttactctta
     8221 ggttcattcc tactgtcatt aaccacttat gcagccatga acatatccaa aatcgatccg
     8281 ccctgctggt tcaccggtat gaacaatccg gaactccagt taatggtata cggtgaaggc
     8341 atcggccagg catccgtatc agtaaattat cccggtgtat cgctcagcag catcgtgaaa
     8401 ctggaaagca acaattacct gcttgtctac ctacatctcg ataaagaagt aaagccgggc
     8461 aagatgccca tcacatttac ggtcggaaag aagaaattgg tgaaagagta cgaattgaaa
     8521 gcacgcagca aagccggagt cgatcacaaa ggttttgacg catcggatgc attatatctg
     8581 ctgatgccgg accgttttgc caatggcaat ccggataacg accggataga aggcatggcc
     8641 gaatataaag tggaccgcaa cgacccgaac gcacgtcacg gaggcgacct ggccggtatc
     8701 gaacaaaatc tggactattt taccgacttg ggagtgaccg cactctggtt caccccggta
     8761 ctcgaaaata atatgaaagg cggctcatat cacggatatg caacaaccga ttattacaag
     8821 gtagacccac gtttcggcac taacgaggaa tatcgctcac tgatagcgaa agcccacaac
     8881 cagggcatta aggtcgtgat ggacatgatc ttcaatcatt gcggagtaga acatccctgg
     8941 atcaaggaca tgccttcaaa ggactggttc aaccatgcgg acttcaagaa caactttgta
     9001 caaacttcct acaagctgac tccacatgta gatccgtatg cctcggagta cgatttcgac
     9061 cagatgaaca acggctggtt cgtggaagcc atgcctgacc tcaaccaaaa gaaccctcac
     9121 gtatacaaat acctcttgca gaacagcctg tggtggattg agtacgccga tatcgacggc
     9181 atccggatgg acacctaccc gtatgccgat tacgatgcca tgagcaactg gatgaaagaa
     9241 ctgaacgaag aataccccaa ctacaacacg gtgggcgaaa cctgggttac cgaaccggcc
     9301 tatacagcct ggtggcagaa agactccaaa ctctccgccc cgcgcaacag tcacttgaaa
     9361 acagtcatgg atttcagctt cttcgacaaa gtcaacacgg ccaagaatga acaaacggac
     9421 acttggttca aaggattgga ccgtgtctac aacaattttg tatacgatta tctgtatccc
     9481 aatccggctt ccgtactggc tttcatcgag aatcatgaca ccgaccgttt cctgggtgaa
     9541 ggcgaaaacc tcgatatgct gaaacaggcc tccacccttt tattgaccac ccgacgcatc
     9601 ccgcaactct attatggaac ggaggtgatg atgaacggag taaagagtaa aagcgacggc
     9661 tatgtacgaa aggacttccc gggcggatgg acggacgata aagagaatgc cctgactccc
     9721 gagggacgta cccgattgca gaatgaaagc tataacttct accgcaacct gctgaactgg
     9781 cgtaagggca acgatgtgat cgccaaaggc agcatgaaac agttcatggt acagcacggc
     9841 gtatatgctt atgcacgcca atataaaggg aaaacggtat tcgtcctgtt gaacggtacg
     9901 gataaagagg tgaaacttcc cctgaaatac tatgccgaag tgctgaaaga caagactcaa
     9961 ggaaaagacg tcattagcgg aaaagtaacg gcactcaatg aagaactgac aatggcaccc
    10021 cgccaatcga tggttataga gctttaatct cacaccggtt ataaccgcat aagcaaaggg
    10081 cacaaaggat ttcacccgac atcctctgtg ccctttgtgt agcctaatgc gaataataat
    10141 agtcaaacat ttgactatta tcgaagaata ttcctacctt tgcagcgact aaaagaatac
    10201 gacgatgaca aacaacgaat cggagcgcga gctcgtccta caaaccttac gaacctggat
    10261 ggcattccgc caagccgttc agcgggtact caaacgtcac aacgtggata tgaccttcga
    10321 gatgctgcaa gtaatgaact gcctgtggaa caaacaaggc atcagccagc aatccctggc
    10381 tgagaaaaca gcaaaggaca aggcttgcct gaccaatctg attaataatc tggaaaagaa
    10441 aaactgggtg ataaggaaag aaggcccctc cgaccgccga aaccgcctga ttttcctgac
    10501 gccccaaggc gaagaacttg ccctcaccgt gaaacccctg atcaacgata tctatgccca
    10561 aaccggaaca gagatggagg caagccggat aacggaatgc atcgaagatc tgaagagact
    10621 gcatgaagtg ctcaatgaga tctaaaagaa atccgccatg tccacccatc agataaagct
    10681 aaaacaattg agaagactga agttcaggaa catctttctc aacacagtat gcatcctgct
    10741 ggcattggca ggtatttcat ggacagtaaa ctacttctgg aaatacgccc gctacgagat
    10801 aaccaatgat gccgtagtgg atcaatacat cgctccgcta aacatccgga taccgggcta
    10861 tatcaaagaa gtacgtttta ccgaacacca gtatgttcat gccggcgaca cgttactgat
    10921 actggacgac cgggaatacc ggatccggct gaaagacgcg gaagcggcct tgatggatgc
    10981 cttgggatca aaggaagtgt taaactccgg catccggact tcaggagtaa atgtagccgt
    11041 acaagaagcc aacatagccg aaacactggc acgcctttca cagcaagaag cggaactgaa
    11101 ccgatatacc cggctcctga aaaagcaggc cgtcagccaa caggattatg aactggccaa
    11161 agcgaacttc gaagcgaccc gggcaagata caacgccctg ttgcgacaaa aagaagcggc
    11221 ccaatcacag tattccgaaa ccagcaaacg cagtacaggc gccgaagcca atatcctccg
    11281 gaaggaagcc gacctggaga tggcccgact aaacctgtcg tataccgttg tcaccgcacc
    11341 ctatgacgga tacacgggac gacgtacact tgaaccggga cagttcgtac aaggcggaca
    11401 aactctttcc tacctggtac ggggcaatga caagtgggtg acagccaatt ataaagagac
    11461 tcaaatagcc catatctata tcgggcaaaa agtccgcatc aaagtagatg ctttcagcgg
    11521 acgcactttt cacgggaccg taaccgccat ttccgaagcc accggatcga aatactccct
    11581 ggtaccgacc gacaattcgg cagggaactt cgtcaaagtg cagcaacgca ttccggtccg
    11641 catcgatctc aatgacgcct cacccgaaga gatggaatgt ctccgtgcag ggatgatggt
    11701 agaaacggaa gcggtccgcc cttaggctta tggtgaagct caatctgcct acccgtccct
    11761 gggtgcctca atggttgggc atcgtgacca tgtttattgt catctttccc atcaccctgc
    11821 tcaacggtgc ctacacagga agtatggtcg aagtatcgaa cacgctggga gtattgagcg
    11881 aagatattac catggcttac tattcagctt cggtagggat ggctgttgcc tatcccatcg
    11941 taccgaaaat acgcaccata gccactccga aaaccttact gctcactgac ctgctgctac
    12001 agatattctt cagcctggta tgcgccaaaa ccggtagtat ggatgtcatc atggtatgca
    12061 gtttctgtat gggatttctc aaagccttcg tcatgttgga gttcatcatc ctgatccgcc
    12121 cgctcttcag tccgaaaaac gtacgaagtg aattctatgc ctacttctac cccatcgttt
    12181 tctccggagg tcagctatcg atggctatca ccgctcaact ggcctatcac taccaatggc
    12241 agcacatgta ctattttgtc accatcctct tgctgatcgc cattctgttc gtcatctgtt
    12301 tcttccgcta tgcaaggcgt cccatgcaca ttccgttcaa agagatggac ggaagaagca
    12361 tgttcatcat cgccaccgct ttcctgctaa cgctctatac atttacctac gggaaaacac
    12421 tcgattggtt cgcatccccg aagatcagag tatatgtatt cgtcatcccg ctcctgatag
    12481 ctctcttcat ccatcggcag cgtacacaag gcaaaccctt tgtcagcctg aaaccactct
    12541 ttctgcataa atccatcatc ggatatagct tcatggtact cgccatgttc ctgacagcca
    12601 ccagttcact ggtaaccaac tatatgaaca gcatcatccg ggtagacagc atacacgcca
    12661 attcgctgag cctgtggcta ttgcccggat atgtggtagg ggccgtcatt tgcttctggt
    12721 ggttccgatg gcaacgatgg cggtttcgct tcctcatttc aggaggtatg ttctgctacg
    12781 tcatctatct ggctatcctc tactttggta tcacccctta tggaacttat gaaatgctct
    12841 acctccccat cctgttccgg ggagtgggga tgatggtcat attcattgcg ttcggtgtgt
    12901 ttgttgtcga agatttagac ccgcgtctga cgttgtccaa tgccttcttc ctgatttcat
    12961 tccgctcagt attggctccg gtcctgtccg cttcgttctt taacaacatg ctttactatc
    13021 tgcaggcaaa ggggatgaac attctttcgg aaaacatgac gctgaccaat ccgctggccg
    13081 aacaaaaata caatcaggca ttgagcaatg ccctggcgca agggcacgaa ttcggcgagg
    13141 ccggacaatt ggcagccaac agcctgtact ccactttgca gcagcaatcc ctgctgcttg
    13201 ccctgaaaac cctgatcggc tatgtactga tactggcact ggtgattgct gtcatcgcag
    13261 cgttcattcc tttccataaa acgctgaagg tggctgtagt gaagacgggt gacgatatgg
    13321 tataatgaga agggatacaa aaaagccacc caattgcttg agtggcttct taaaatataa
    13381 attaaatcaa gtaaaacttt taaatactag atttggaatt tattcagcta acttgttgtc
    13441 agaacccagc acgttgataa ttttgtgctt gtagagtttt tccatattgt cgcgagccgg
    13501 tcccaaatat ttacgcgggt cgaactcagc cggtttttct gcgaatacct tacggatagc
    13561 ggcagtcata gccaagcgag agtctgagtc gatgttgatt ttgcaaacag cagacttagc
    13621 ggctttacgc agttcctctt caggaatacc gatagcagct ttcagtgcac caccaaactg
    13681 gttgatagtt gcaacctctt cttcaggaac tgaagatgat ccgtgaagaa cgatagggaa
    13741 tcccggaagt tctttcatta caccgtccaa tacgtcgaat gccaacggag gaggaaccat
    13801 acggcctgtc ttcggatcga tgtggcactg ttccggagta aatttgtaag caccgtgaga
    13861 agtaccgata gagatagcca atgaatcgca acctgtcttg gtaacgaaat caactacttc
    13921 gtccggttca gtatatgtgt ggtggtcaga agaaacttcg tcttctacac ctgccaatac
    13981 gccaagttca ccttctacag ttacatcgaa ctggtgagcg tattcaacaa ctttcttagt
    14041 cagagcaacg ttttcgtcgt aaggaaggtg agaaccgtcg atcattacag aagagaaacc
    14101 tgagtcgata cagcttttgc aagtttcgaa agtatctccg tggtcgaggt gcaaaacgat
    14161 ttcaggattt ttgcagccga gttcttttgc atattctaca gcaccctgag ccatgtaacg
    14221 caacaatgta gcgttagcat actgacgagc accttttgat acctgcaaaa taaccggaga
    14281 cttagtttct acagcagcct tgatgatagc ctgcatctgt tccatattgt tgaagttgaa
    14341 tgcagggatt gcatatccac ccttgatagc cttagcaaac atatctctag tgtttaccag
    14401 acctaaatct ttgtaattaa ccattttgtt taaaagttta ttgttagtga attaaaaatt
    14461 ctatgcaaaa gtaagaataa tcctttgaat agagaaaccc tcgggcggaa atatccgttt
    14521 gaggagcgta attcaattct atttcaaatt atttcccatc ctttaagagc tgtttgtaat
    14581 gtctacgtag caaataaagg ttttttattg tttcctcata tatataatgg taggcaaatg
    14641 atcgctgtaa ccatccaacc acactctgcc accatatgta cgcaggggtg cacccttata
    14701 tttaccatcc tgctgaaaca ggtaatcgcg catgaaaact tcattgtgat catatttcaa
    14761 tccttttgtt gcttgaagca gcgtgggtga aaggatgatc tgatcgaaca gattccattt
    14821 gcctcgatag agcaaagtgc ccactccctt atcttccagc gtcacccacc aggggttgta
    14881 aaggt
//
