LOCUS       gnlProkkaKELFKKGH_366  13668 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KELFKKGH_366.
ACCESSION   gnlProkkaKELFKKGH_366
VERSION     gnlProkkaKELFKKGH_366
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:09:47
            Original ID  :: gnl|Prokka|KELFKKGH_366
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 9116
            Orig. end    :: 22784
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13668
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13668
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13668
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2485..3162
                     /locus_tag="ctg366_9"
                     /transl_table=11
                     /translation="MTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNLD
                     EVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAEL
                     MPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVN
                     LIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKN
                     NES"
     CDS             3868..4221
                     /locus_tag="ctg366_10"
                     /transl_table=11
                     /translation="MKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGD
                     FMGGPYVSHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIP
                     LGEASKEAEQTNK"
     CDS             4226..5320
                     /locus_tag="ctg366_11"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5330..6571
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 387.1; E-value:
                     2e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg366_12"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6558..7085
                     /locus_tag="ctg366_13"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7091..7864
                     /locus_tag="ctg366_14"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             8051..8266
                     /locus_tag="ctg366_15"
                     /transl_table=11
                     /translation="MVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAPQ
                     TEAPATNAPATETPAPATETPAPAAE"
     CDS             8593..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 85.5; E-value: 4.7e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg366_16"
                     /transl_table=11
                     /translation="MLCGYFLTDVMSPLKPMLEKELLWDSLDYGFFTSAYGWFNVFLLM
                     LIFGGIILDKMGVRFTGMGACLLMVFGCGLKYYAISTTFPEGAMLFGFKTQVTLAALGY
                     AIFGVGVEIAGITVSKIIVKWFKGKEMALAMGLEMATARIGTTLAMVLTVPLADFFGST
                     DESGTFHTNIPAPILFCLIMLCVGTIAFFLYTFYDKKLDASLDAEGLEPEEPFRMKDIV
                     YIITNKGFWLIALLCVLFYSAVFPFIKYAADLMVQKYNVDPKLAGTIPGLLPIGAIILT
                     PLFGSLYDRIGKGATLMIIGSVMLIFVHTMFALPILNIWWFATIIMIILGFAFSLVPSA
                     MWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVPLLIGWVLNTYCKGPVVDGAQTYDYTL
                     PMAIFALFGVLALIVALMLKAENKKKGYGLEEANIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg366_17"
                     /sec_met_domain="PqqD_RRE (E-value: 4.8e-11, bitscore:
                     32.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.7e-17, bitscore: 54.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQYEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(10370..10654)
                     /locus_tag="ctg366_18"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10691..11758)
                     /locus_tag="ctg366_19"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11832..13343)
                     /locus_tag="ctg366_20"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCHTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYST
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
ORIGIN
        1 acgctcattt ccagttgaat ggcttttcac aggcggatgc caagtcgttc tcaaagcaat
       61 atttgtctac ttactccaag gctttgtctg cacagcagga agatattctt gcttcgtggg
      121 tgctggctaa acaaccgcgt tgtttaagtg tattgctcaa cgagctggtt tcgttcggtc
      181 agtacgatgc tctcaatgaa tatatgagtg gatattgccg gctcaatgag gttgggcaat
      241 tctatgacag tgtgctacgg cgtttgtcgg ctgattatgg gttcgaagag attggaagaa
      301 cgcttctgat gctttcactt actttagaag gatttaccga agatgaagtg aagagcatgg
      361 cagacattaa tcagatactt tggtcgcagt tgagagtgga aatgagcagc tggctcacca
      421 acaaaggagg gcgatattgc attggtgaca cacaaatggt agaggcaatc gaacgctatt
      481 tcgctcaaga tgacgaatgt atagatgata gtcgccatga aattatttcc gctctgctgg
      541 atgaggaaga gatcctttcc catccgttga cttttgccga ttataactat cgcatgaaac
      601 agttctgcta ccatgattcg tatcgctata aagtggagat tacctatcaa tgctataaga
      661 tgcaagaatg ggatatattg aaggattgga tttgtgatgt ggagattttc gagattctgt
      721 atcgcacgaa tcgttctctg ttggaagata gctggaaggc gatcatgaac gacaatcctg
      781 aagttacgcc tgaagtctat gccgaattgg actttgatga gatcgattct tttttaattc
      841 ctgtcattgc taatgatatg gctactttct tgagcagttc tttccatctg acgaaggcgg
      901 cagctgctgt gagtgagaag agtatggaag gcgctgccat gccactcatt gccaagtcgg
      961 tattgaagat gaatgaggga tgccgctatg cccgtaatga agaatacgaa acggcatgcg
     1021 actgtttcct gaaagcattg gtgatgcagg aaaacatagt accgactccg gaactggaga
     1081 ttgccaacac ctgccgaaat ctagctctgg catattacta caatgagcaa tacaatgaag
     1141 cggtgaccta tctgaatagg gcgcttgatt atcatgcagc ttctgctgac gagaagagtc
     1201 aggcagaagt cattgaactt tccgaatatc tggcttattg tgattactat aaggatgagg
     1261 aagagagtgc tgccgagaaa ttccggaaag tagctgaaat gcacgagtcg ttgaatggca
     1321 gactgtccgg tggagtggct aaatgtttgc gtatgcaggg taaatgtctt tattatatca
     1381 aacgatacga tgaagcatgg atgctgatga atcaggcgtt ggacattgct atacagatag
     1441 atagcaaaaa acagatcgtc gcttgtcata aacagttgta ttatctgtgc agggaattca
     1501 aacggatgat gaatgaacgt ggcgatgagc aggcatctac tttattcttc cgtgagtctc
     1561 ttctgcatga aatgtatttc agcgaaaaac cgcgtctggc ggaactgact gtccgctacg
     1621 aggcattgag atgtgatatt atgcagcagt attacatgaa taaagactat gataacgtga
     1681 ttcgtattgc aacgtctttg gattttcacg atgatactga ccctaatgct tcctgtctgg
     1741 tatattatta caaagcacag gcttatgtga agttggagaa ttatccaatg gcgaaagagg
     1801 cttttttcag agagcttgaa ctgcgaaaga aatatctggg atgggaggat gaagatacga
     1861 ttctggcttg tcagaaccta ggggttttgc acagcttttg taatgaacgg gaagaggcgc
     1921 tggcttgttt ccgtgaggcg tacggtcatg aagtgaaaaa gaatggcgag gattctgaaa
     1981 tggcgcaaaa gctacttcaa tatatcagcg tggttgaatc ataacggagg catacttccc
     2041 ttttttgtta acttttacat tcctgctata cggaaatcga ctttatttcc ttacatttgc
     2101 agatataaac tatcaacaga aagaagaatg tctaaatatc cccttttagg aatgactctt
     2161 gtagagcttc aatcattgac aaaaagactg ggtatgcccg gctttgctgc caagcagatt
     2221 gcatcctggc tttacgaaaa gaaggtagcc tcgattgatg atatgactaa tttgtcattg
     2281 aaacaccggg agttgctcaa gcagaactat gaggtgggag cggaagctcc ggtagatgaa
     2341 atgcgctctg tagatggtac ggtgaagtat ctttataaag tgggtgagaa ccattttgta
     2401 gagtcggttt atataccgga tgatgaccgg gcaacgttgt gtgtgtcgtc acaagtaggt
     2461 tgcaagatga actgtaagtt ctgtatgacc ggcaaacagg ggtatacggc taacctgacc
     2521 gccagccaga tcatgaacca gattcattcg ctgccggaac gggacaaact gactaatgtc
     2581 gtaatgatgg gaatgggcga gccgctcgat aacctggatg aggtattgaa agcattggaa
     2641 ctactgaccg ctacctacgg ttacgcatgg agtccgaagc gtatcacgct ttctactgtc
     2701 gggctacgga aaggattgca gcgttttatc gaagaaaatg actgccacct tgccatcagc
     2761 cttcactctc cgctgaccgt tcagcgtgct gaattaatgc cggcggaaaa ggcgttttca
     2821 atcaccgaaa tggtggaact gttaaaaaac tatgatttta gtaaacaacg tcgactttcg
     2881 tttgaatata ttgtttttaa agggctcaat gattcgcagg tctatgccaa agagttgctg
     2941 aaacttcttc gcgggctgga ttgcagggtg aatctgattc gttttcatgc cataccgggg
     3001 gtagacctcg agggggcgga tatggatacg atgacccgtt ttcgtgatta tctgacgtca
     3061 cacggacttt tcaccactat ccgttcatcc aggggcgaag atatttttgc tgcttgcggt
     3121 atgctgtcga cagcgaaaca ggagaaaaat aatgaaagtt aatatataaa accgaacatc
     3181 atgaaaaagt actcttttat tttatgcatc gctttggtag cctttgtcgt tgcatcttgt
     3241 ggtctgaaag gaaatcacac ctctagtggt cgtgcttacg agcttttggt tgtagtagat
     3301 cacggtgttt gggatcgtgc tgccggaagg gctttacatg atgcgctcga tgctgatatg
     3361 cccggtttgc cgcagtcgga accttctttc cggattatgt atacttcgcc gaaagattat
     3421 gattctacgc tgaagttgat acgtaacatt attattgtag atatacagga tatatatacg
     3481 aaagcctcgt tcaaatatgc gaaggacgtg tatgccaatc cgcagatgat attgactatc
     3541 caggctccga acgaagaaga gtttgagaag tttgtggaag agaacaaaaa gacgattgtc
     3601 gacttcttta cccgtgcgga aatgaatcgt cagattacgt tcctggaagg gaaacacagt
     3661 aatttcattt cgcagaaagt ggacagtttg ttcggatgcg acatctgggt ggatgccgaa
     3721 ctggctaatt caaagaccgg ggatgatttc ttctgggctt ctaccaacac aggtagtgcc
     3781 gaccgtaact ttgtgatgta ctcttatccg tacactgaca aggatacgtt taccaaagaa
     3841 tattttgtgc acaaacgtga ctccgtgatg aaagccaata tccccggatt caaggagggc
     3901 gtttatatgt cgaccgatag tttgctgacc gatgtccgtc cgatcaatgt acagaacagc
     3961 tacacaatgg aagcacgtgg cctgtggcgt atgaagggcg actttatggg tggtccgtat
     4021 gtatctcata ctcgtctgga cgagaaaaac caacgaatta ttacagcaga aatatttgtt
     4081 tattcacctg ataaaatgaa acgcaacctg gtacgccaga tggaagcatc tctgtataca
     4141 ctgaaacttc cgaatgaagt tcagcagaag cagattccat tgggagaagc atctaaggaa
     4201 gcggaacaaa ctaataaata aaaacatgga agataacaag ataaggatag gtatcaccca
     4261 aggagatatt aacggggtgg gctatgaggt gattcttaag acattttccg accctacgat
     4321 gttggaacta tgtactccga tcatttatgg ctcaccgaaa gtagcggctt atcatcgcaa
     4381 agcgctggat atacaggcca atttcagcat tgtcaactct gctaccgaag cggggtacaa
     4441 ccgtttgagc gtggtgaact gtacggatga tgaggtgaaa gtggaatttt ccaaacccga
     4501 ccccgaagcc ggtaaagctg cgctgggggc tttggaacgt gccatcgaag aatatcgcga
     4561 agggttgata gacgttatcg taacagctcc gatcaacaaa catacgattc agtcggaaga
     4621 gttctccttc cccggacata cggaatatat cgaagaacgt ctgggtaatg gtgataagtc
     4681 attgatgatt ttgatgaaga atgacttccg ggtggctttg gtgacgacac atatccctgt
     4741 cagggagatc gcgactacga ttaccaaaga actgattcag gagaaactga tgatattcca
     4801 tcgttgtctg aaacaggatt tcggtatcgg cgctccgcgt attgcggtgc tctctctcaa
     4861 tcctcatgcc ggagacggtg gcctgttggg aatggaagag caggaagtga ttatccctgc
     4921 catgaaagaa atggaagaga aaggaatcct ttgctacggt ccttatgcgg ccgacggctt
     4981 tatgggttcg ggcaattata ctcattttga cggtatcttg gcgatgtatc acgatcaggg
     5041 gctggctccg ttcaaggcct tggctatgga agacggggtg aactatacgg caggactgcc
     5101 ggtggtacgt acttctccgg ctcatggaac ggcatacgat attgcaggca agggattggc
     5161 ttgtgaagat tctttccgtc aggcaatcta tgttgccatc gatgtgttcc gtaatcgtca
     5221 gcgggaaaaa gtggctcgtg ccaatccgtt gcgtaaacag tattacgaga aacgtgacga
     5281 tagtgataaa ctgaagctgg atacagtaga cgaagattaa aaacgagtga tgacaagagc
     5341 agagatacaa caagtgaaac aacgtttcgg tattataggt aataccgaag cattgtcgcg
     5401 cgccatagat gttgccattc aggtagctcc taccgatttg tctgtgctga ttaccggaga
     5461 aagtggagtc ggaaaagaaa gttttccgca gattattcat caatatagcc ggaggaagca
     5521 cggacagtat attgctgtca actgtggtgc tattccggag ggcacgattg attccgaact
     5581 gttcgggcat gagaagggtg cgtttaccgg tgcgattggc gaacggaaag ggtactttgg
     5641 cgaagccgac ggtggtacta tttttcttga tgaagtaggg gagttgccga tgcctaccca
     5701 ggcgcgtttg ctccgtgtgt tggagagtgg cgagtttata aaagtaggtt cgtccaaagt
     5761 gcaaaagacg gatgttcgta ttgtggcagc taccaatgtc aatcttacac aagcgattgc
     5821 agaaggacgt ttccgtgaag atttatatta ccggttgaat acggtgccta tccaaatacc
     5881 gcctttgcgt gaacgtggtg acgatgtact tttgttgttc cgtaagtttt ccgcagactt
     5941 tgcagagaaa taccggatgc ctgctattca gttgacggag gatgcgaaga aagagttgtt
     6001 ggcttacccg tggcccggaa acgtgcgcca gttgaagaac atcaccgagc aaatatctat
     6061 cattgaaacc aacagggaga tctctgctgc tatcttgcag aattatcttc ctgcacaaaa
     6121 tacgcaacgt cttcccgcgt tgatgggaac gcgtgagagt aaaggctttg agagcgaacg
     6181 ggagattctt tattctgttc tgttcgatat gcgccaggaa gtggcggagc tgaagaagat
     6241 ggtgcacaac ctgatggcgg aacgtgccgg acaggtgggg caggtaggac aaatgggaac
     6301 ggtggttact actccggtag tgacggcgca tcaaccttcg gtacctgcta tcattcacac
     6361 catgcagcct acggtttgca aggatgatga tgacatacaa gacacggaag aatatgtaga
     6421 agaatcccct ttgtcactgg acgaagtgga gaaagaaatg atacgcaagg cacttgagag
     6481 gcatcatgga aagcggaaga gtgcggccaa ggacttgaat atttccgagc gtacacttta
     6541 tagaaaaata aaagaatatg aattggatta agaaaataat acgccctttg ttactgttcg
     6601 gcttgccgtt ggtagtcatt gcgtgcactg tttcctataa gtttaacgga tcgtctatca
     6661 attatgataa ggtaaagacc atttcgatag ccgacttccc gatcaagtcg gagtatgtat
     6721 atgctccgtt agcaaccaaa ttcaatgagg acctgaaaga tatcttcatc cggcagaccc
     6781 gtctgcaact gctcaagccg aatcagaatg cggacttgca gattgacgga gaaatcacag
     6841 gatacaatca gtacaaccag gcagtatctg ccgacggtta ctcttcggag acgaagttga
     6901 ctattaccgt caatgtacgt tttgtcaaca acaccaatca tgccgaagac tttgaacaac
     6961 agttttctgc gttccgtacc tacgactcta gccagttgct gactgccgta caggacggat
     7021 tgattgctga aatgtctaaa gagatcaccg accaaatttt taatgcaact gtagcaaact
     7081 ggtaatataa atgacttctg ttaactttca acaatggatt cagcatcccg agacgctgaa
     7141 tagggatact ttgtacgaac tgcgcaatct tcttgcgagg tatccgtatt ttcagtcact
     7201 tcgtctgctg tatctgaaga atctgtatat tctccatgat attagtttcg gtggagaact
     7261 gcggaaagca gttctttaca ttgcagacag acggcagttg ttccggttga ttgaaggtga
     7321 ccgctatgat gtgcaggcac ggaaaaaggg agtacctctc acggaggtgc tgaaagacga
     7381 accgtccgta gaccgcacat tagcattgat cgacgctttc ttgtctacag tacccgaaga
     7441 ggtgactgcc cgcaccagct tcgactattc gatggattac acctcttatc ttttggagga
     7501 gactccggcc acggaacagt cggccgaaga aacgcccaaa ctcaaaggct acgaactgat
     7561 tgacgacttt atagaaaaga gcgagagcga ctctcccctc tgcaagaaac ctttaagaga
     7621 agaaatgcca tcttcgccaa cctcttcgga cgaacttacc gaagaagaaa caatgaagga
     7681 agaagaggaa gatgacagct gttttacgga aactttggca aaaatctatg ttaaacagca
     7741 acgatattca aaagctcttg aaataattaa aaaattaagc ttgaaatatc caaaaaaaaa
     7801 tgcttacttt gcagaccaaa tcagattttt ggagaaattg attattaacg ctaattcaaa
     7861 ataactaaaa atgtacttat tattcgttat cttaatggtt attgcagcct tgttgatgtg
     7921 tttcatcgtg ctgattcaga actcaaaagg aggcggactt gcttctggtt tctcttcatc
     7981 taacgccatc atgggcgtgc gcaagactac agattttctg gaaaaagcaa catggggctt
     8041 agctatcttc atggtggtaa tgagcattgc tactgcttat gtagttcctc gctctgctgt
     8101 tgctaaagac gcagtgttgg aacaggcaca gaaagaacaa cagactaacc cgtataactt
     8161 acccgcaggt acggctgcgc cgcaaactga agctcctgct accaatgcac ctgctacaga
     8221 aactccggca ccggctactg aaactcctgc tcctgcagca gagtaattca ctccgttgtc
     8281 aggtaagact ttggggtaaa accattaatg ggaaggtgca gacggatgct gcatttcttt
     8341 gatatttaag tgcggattac gcagattaca cggattttca atcttccgcg tggtcagtgt
     8401 aatccgcact taactttttc ttgtaaaaac aatctctttt tgatagaaac aaacgagatt
     8461 taactacctt tgttggtcgt atgaagatta ttaactactt ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt cttgattatg gtttcttcac aagcgcttac
     8701 gggtggttta atgtattcct gttgatgctg attttcggtg gtatcatttt ggataagatg
     8761 ggagttcgtt tcaccggaat gggggcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tctttggatt caaaacacag
     8881 gtaaccctgg ccgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca aaattatcgt aaaatggttc aagggtaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgctcac ggttcctttg
     9061 gccgacttct tcggatctac ggatgagagt ggcacattcc ataccaatat tcctgctccg
     9121 attttgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagagggat tggaaccgga agaaccgttc
     9241 cgtatgaaag atattgtgta tatcattacg aataagggat tctggttgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtattcccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata atgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattatcc tgactccgtt gttcggctcg ctttatgacc gtatcggtaa gggagctacg
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgttcgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactatcatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtacc
     9661 gcatacgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgac
     9781 tacacgttgc cgatggctat ttttgctctc tttggtgtgc ttgctctgat tgtggctttg
     9841 atgttaaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tatccaaaag
     9901 taactgggaa attcaatacc taaagtgaca aaggaatttt gtatcaaggt gtaaacagaa
     9961 gagtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 atatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagtcgtata aataggaact tattattatt tatttgataa
    10381 atacagccca aagtatgacg gcaattgcta tcaggacccc catgataata agcgttcccc
    10441 aaacaaaata attgctgtct ttctctttct ttttctccga gtcgtggatg atacgttcca
    10501 tttcttcggg ggtggtgttg ggtagtggat aaggttcgtt tgcacggttt agatgcttca
    10561 acttatcgtt agcacgttca cgacgtaggc gggaagcttc ccgtccctct tttattcggc
    10621 gtatcatgtc gaatgcatgt ccttcaccaa ccatattctt tgttttttag aagtttactt
    10681 cctcgttttt ctatttccct tcttctctgt ccactttgag caatcctccc gtattcggat
    10741 caaaataaac tttgatggta gaattcttgt tgaacaaaac cggagccaga tattctatca
    10801 caccaaattg agtaatagga agctcacctt cgtaaagttt ctttttaccg tcggtcagtg
    10861 taaccatagc ttgtccgggg acgttgtagg cgattccatc caaatctttc ttcttcttac
    10921 catcttcctg tggcatcttg accgatttca ggtctttcag actgatataa aacggagttc
    10981 ctgccaaatc attgttggca actacaccta acttcttcga gaagcggaaa gcaacttcat
    11041 tgttgaattc cttgtcaggg gtaaggcgga cagtgaatgt tctctcttct ttgttgcagg
    11101 tgccggagaa catttgcgtc atggcttctt cctgtgcatt cagattgtcg agcataattt
    11161 taagctgtgc tccgtctgaa ggcatattgt cagcctgtcc gcgcaataag gcatttttgc
    11221 tttcgcggat gttatagatc tctttagcca ccagctcggc catcttggcg gtagagctgg
    11281 ccatcagaat ctcctcggtc aggaattcac gaggattcgc tttcttttgg aggactgcgg
    11341 gggcgggagc agcttttttg cctacactgc tattgctgta aggaacattg atcgttttca
    11401 caatgccatc ctctgtcagt tccatgagcg gtgctactgt cttatccttc aattttacga
    11461 aatacgtagt ttcgctgttg ggcacaccta cggatttcac ttttacgcta gccagttccc
    11521 agtactcttc agggtcggcg gagacgttgg tcagtcgcag gtaacgatca gcatatttgc
    11581 tgaattctcc cggagtatag ttgactttgt tggcttttat ttcaagttct atttgggttt
    11641 tgggaagact gtaaaccact ccatagtctt ttcctcgggt aacccctgtc agtacttcgg
    11701 tttgtgcata ggcggacgtt gtcattagta gtcctgctgc tataatcaac tttttcatat
    11761 tcggttcttt tttaactggt tttgaaaaca aagttaatga agttattgaa aaaagggtaa
    11821 gttcttaact tttattcgct tacaagttgc catgctgtcg gcagacaggt gataatatcg
    11881 cttgcgatca ttccgatcat tccttgcttc ttttgagcga catcgcccgc caatccgtga
    11941 atgtaagtgc cgattttagc ggcttcttcg gttgagtaac cttgggcaag cagtgccagg
    12001 attactccgg tcagtacgtc accgctacct ccggttgcca ttcccggatt tccggttggg
    12061 ttgaagaaac atttaccttc tggggtgata atggcggagt aggctccttt taaaataatg
    12121 tgaacatggg cggcacgagc caattcgcaa gccttcatca gacgttcgta agagtcctgg
    12181 catttgccgg tcagacgttc cagttctttc ggatgcgggg tgaggatgga acccttcggc
    12241 aggtgggtaa gtgcatgacg gtggttggcg aggatattaa gtgcgtcggc atccaccaca
    12301 acaggagtat ggcaatgttc cagttgctcc aataaagcag cttccgtttc ctcgtttcgt
    12361 cccagccctg ggccgatgcc gactgcttga tagtcgtccg tgtcggtagg tacggcaaaa
    12421 caggtttcgt tgatgtcggt ttctacgatt gcttcgggta tggaggtctg caagatgtcg
    12481 ttgttgcaca ttggcgcatg gacagtcagc aaccctactc ccgaacggag gcaggcgcgg
    12541 gcagcgagaa cagaggctcc tgccattcct tttgaaccgg caatcaatag tgcatggccg
    12601 aagttcccct tgtgggcaaa ctgtttgcgt ggcttgatga gtgaacggat ttgctctatt
    12661 tccaacattt cgtagttcgt ttccatctct tcaataccgt cttcgcttaa ttggatgtcc
    12721 agcacttccc attctccgac aaattccgtg ttctctgcga aaagaaaggc gagcttcggc
    12781 agttgcagac tgaaagttac gtcggcacgg ataatattag cttttacgtt gaatgtgttt
    12841 tcttctccca tcagtccgga aggaatgtcg atggctacta ccatagcagg ggaggaattg
    12901 atgtatttca ctacggcagc gaatccgccg cttaacggtt tgttcaggcc tgaaccgaat
    12961 aatccgtcga ttaccagatg gtcgggcgtc aggacgggag gtacgaattg ggtactgatt
    13021 tcgtggaatt ttacttcttc catcatttct accagttctt tattggtttg gcagtcgggt
    13081 gaaagttctc ctttcgtgtt gaagagaaat acctcgattt tatatccttt ttcagccatc
    13141 atgcgggcta cggcgagagc gtctccgcca ttattccccg gtccggcaaa gatagtgacc
    13201 ggcgtttccg tattccatct gtctgtgatg gcttttgtta atacggttgc tgcacgttcc
    13261 atcagatcga ttgatgcaat aggttcgttc tcaatggtat aagcgtccaa tttcttgata
    13321 ctgctgcttg gaaatatttt cattgcgatg ttcttttagt tttcggatta caaatgtaca
    13381 tgattcttct gacttttccc gtttgttgtg ggaagaaaac cataattgca acttttaatt
    13441 catcattagt tctatctttg ggtcagagaa atatctgctt ttgaactatt aagtgttaga
    13501 ataactccgc caaaaaataa ttcaatgcag caccattatg aacttacttt tatttctcct
    13561 gaaaaagatt tggttcttaa tcaaattccg tgctagtaaa gctcattgaa aggccgatgg
    13621 ataaagggat atcggcatat tagaaatagc aaataaatta tccaaact
//
