LOCUS       gnlProkkaJCIMKLNM_360  12402 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JCIMKLNM_360.
ACCESSION   gnlProkkaJCIMKLNM_360
VERSION     gnlProkkaJCIMKLNM_360
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:33:39
            Original ID  :: gnl|Prokka|JCIMKLNM_360
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12402
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1881)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 2.1e-83.
                     Score: 272.0. Matches aSDomain:
                     nrpspksdomains_ctg360_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 1.9e-10.
                     Score: 33.0. Matches aSDomain:
                     nrpspksdomains_ctg360_1_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     260.3; E-value: 4.6e-79)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg360_1"
                     /sec_met_domain="AMP-binding (E-value: 2.1e-88, bitscore:
                     285.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.1e-11, bitscore:
                     33.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQKNLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPNDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPAGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRHEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFN"
     protocluster    1..12402
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:1881]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..1881
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..12402
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12402
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     aSDomain        complement(178..354)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg360_1_PP-binding.1"
                     /evalue="1.90E-10"
                     /label="ctg360_1_PP-binding.1"
                     /locus_tag="ctg360_1"
                     /protein_end="568"
                     /protein_start="509"
                     /score="33.0"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(178..1845)
                     /complete
                     /domains="nrpspksdomains_ctg360_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg360_1_PP-binding.1"
                     /locus_tags="ctg360_1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(652..714)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg360_1_0004"
                     /evalue="1.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg360_1"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.6"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(679..1845)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg360_1_AMP-binding.1"
                     /evalue="2.10E-83"
                     /label="ctg360_1_AMP-binding.1"
                     /locus_tag="ctg360_1"
                     /protein_end="401"
                     /protein_start="12"
                     /score="272.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRQLYLNGEQLSEPVVGDYTEVLPNDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLIDKKLYHLSDPANRYLAFASISFDASILELMMCIPAGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLGATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(787..873)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg360_1_0003"
                     /evalue="8.80E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg360_1"
                     /protein_end="365"
                     /protein_start="336"
                     /score="27.7"
                     /tool="antismash"
                     /translation="LGATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(1375..1431)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg360_1_0002"
                     /evalue="1.10E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg360_1"
                     /protein_end="169"
                     /protein_start="150"
                     /score="27.2"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(1612..1653)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg360_1_0001"
                     /evalue="2.60E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg360_1"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.4"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(1894..4260)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 167.8; E-value: 8.8e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg360_2"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHKN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNETD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(4257..5093)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 136.3; E-value: 3e-41)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg360_3"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMGPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(5116..7953)
                     /locus_tag="ctg360_4"
                     /transl_table=11
                     /translation="MKKIVFLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYNRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTDSLGELEDMAEIDKRIYLKATSGRYYTVQSDSILTPVQVLPAQLQ
                     EKWRNQSSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISVVSYKGMIYIGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLAFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGESSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPCIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(7950..9551)
                     /locus_tag="ctg360_5"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     ARAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCINHEIQPYFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLTNERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFIGDEQGRLYRVPVSPDHMATVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             complement(9548..9976)
                     /locus_tag="ctg360_6"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             complement(9991..10296)
                     /locus_tag="ctg360_7"
                     /transl_table=11
                     /translation="MEKYEIHFVGSVLDSNTSGDEQAKIVALIEQGHSVALDLSGCSYV
                     SSAGLRVMLYVFKLAKAKSRDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             complement(10315..11484)
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 219.1; E-value: 2.2e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg360_8"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKTGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             11832..12401
                     /locus_tag="ctg360_9"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SDSCIELIIYGTHGNEKEICKLTKPDIKDLSYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTQKNNTLTY
                     YECSKFEVDINHPFTGTEFKTYCLNLK"
ORIGIN
        1 attaaaatga tcgtagatag catctacaac tagaaagtca tatttgggat aaaggcggtc
       61 ggccaaatta aagtacaaat gattaaaata ggcagatcca caaaccagaa tgattacggg
      121 tttcttcagg ttttgctgcc tgtaccaata gataggttca tgccgcggaa cgagcaataa
      181 tcggcgcaga ttacgggcag tataaactgc agatacgttg atgggacatc cttttttatt
      241 ggcctcggta acaagcctca acatatccag cgaagttaat cccagatcat caatcaaatc
      301 ggcctcaaca ctgacttgag gcaaacctaa catttccttc aaaattccac ataagataac
      361 ctcccccgga tgaacaggag gaacatactt caactccaat gaagtaaaag ccgggagcgc
      421 ccggacatca atcttatcat ttatagtacg ctgaaaatga tctaccacct gccataaatt
      481 gggtatcatg tagtaaggaa gttctgcacg caaacgttct ttgacctctt ccggatgaaa
      541 gttaccggag actgagggtt gcaaataagc tcccaataat tgacgcccat tccgctcaac
      601 aactactacg tgggctctct ccacgtccgg atctctattc aatcgttctg ctatttcagt
      661 caattcgata cgaaagccac gtattttgac ctgagtatct tttcgcccga taaaccgtat
      721 tgaaccgtcc ggttgctgct gtaccaagtc acctgtcctg tacaaccgtt ctccatcgta
      781 cgagatgaat gatttttcat tcagctgaac actcccaata tatcccagcg aaacctgagg
      841 tcctcccaag caaagttctc ctgtagcccc aagagttgtc tgttggaggt tttcagacaa
      901 aacataacag acagttccct tgagcggata gccaatatcg tcatacgacg tatctttgcc
      961 tacaatccgt atggtactga gtacggtatt ctctgtcggt ccatatacat tcatcaaccg
     1021 gtaaggctgc tgtttcagcc tgttaaataa cttttcacca atagcctccg caccaaagag
     1081 cagagtctta aaggatggaa agtcaaggtc ggcaaacatg cccagcaacg aaggaggaaa
     1141 aaaagcaata ttcaccttct cgcgcctaat cagttcgtct agtaaagaaa tatctctgcg
     1201 ttcgtcctca ccggccagga tcaatgttcc tccggccgga atacacatca tcagttctaa
     1261 tatggaagca tcaaaactga tactcgcaaa cgccaggtac ctgtttgccg gatcagacaa
     1321 atgatacaat ttcttatcta tcagattcct cgtaaatgta tccagattcc gataactaat
     1381 acgtacacct ttaggattgc ctgttgttcc ggaagtatat ataatatagg cgcaatcatt
     1441 gggaagaact tcagtatagt caccaacaac cggttcggat agttgctccc cattcaggta
     1501 aagttggcgg acggacggaa ttccacctac ttcattcgat gaatcggtca acaacaaaac
     1561 catatccgca ttttcagcca tataccgttt acgattatcc ggcagcgagg gatctatcgg
     1621 taaataagtt gcccctaacc ggaaaatagc cagaatggca ggtactaaag ttttgtttcg
     1681 ttccatacaa actccgatac agatattccg aagtccggac ggatcagtta ccgataaacg
     1741 ttgacggata gattgtgcta tattggcaga gtaacgttcc agcatttgat aagagacggt
     1801 accgtctttt gcaacgaccg ccggtttgtc accccaggta gagagtgatc gagaaagatt
     1861 tttttgaatg tttgttttca ttattagttt gatttagaaa ttatacaata tactggcgga
     1921 aatccacctt cctttctggc ggataggaac agtcgctcct ccgcattcat atcggttatt
     1981 gaaaagattc tcaatgccca gactgccttc tatcctttta tacttatatc tggtagtgaa
     2041 agaaaagaca gcataaccgg gcaaacggac tgtgtaattc gtcgcatctc cattgagtcc
     2101 atcttccaat acacttacct gagtgtagca gtggctactg caattcaatt ttaaatgggc
     2161 agaccagctc tgtactttct ttttaagtaa aaagtagttt gctacaagat tcatagaaaa
     2221 gccgggtacg ttattcacag atccatcggt aacaaaaaaa ttggtataat tcaatacttt
     2281 ctgaaaacac aggtttccat ccaggctcag tcggtctgcc ttataacggg caacaacctc
     2341 gacacctccc atatccagag aaccggcatt ttcataaaca cgtgtttccg gctgtgtgaa
     2401 caggaaatgg gacgcccgat tataaaataa attacactct acatctatat gtgaaggtga
     2461 atgatgataa gcacaagtca cctgatatga acttagatat tcagcttgca gattttcgcc
     2521 acccgaatag gtatccgttt cattgtttct gtaataatag ggcgcatcga caaatgctct
     2581 ggaataactg gctttgatat ttaatccgtt cctgagataa attagtgaca gacggggaga
     2641 aaaagcctgt aatgttcgct tattacttcg ccgtttatag tcatacctga tgccggcatt
     2701 gacaatccaa tttttatgca ggttgtgttt aatctgaaga aaggcatccg tgttcatctc
     2761 gtgtcccgtg taaagtcgtt tttcgatcca cgtcctgacg atctctttaa aattcatacc
     2821 ttccaaatac tcggaatcat aaagcgtata ccgattccat tccacaccgc caagcatatt
     2881 gcctttcccc agcttccccc aatcataggc atagtttaca cgcccattaa agcctacgtt
     2941 aaaatccatc cagcggatgt attgaaatgc tccgcgagtc ggataaataa taggttgata
     3001 atcatagtta ggaaaaatag gatagtcttg taaagtatct cccgaggttt cataatgtac
     3061 gtttttattc caatcggtat aaaatgcggt actgaaagtg atccgctgcc acgtgcggct
     3121 ataaacagcc tgttctcttg ccgaccacct ggaatatccc gggccggaac cgtcaaaagt
     3181 acgaaaccgc tcataagaat atggagaaga aaagagccac atgctataag gttgcctttt
     3241 cttcgcgtaa ttcatactga aactaaaaag caaatttcca cgttgcaatt taattcctcc
     3301 atccatggca ggaaatcccg aataattgtc cagacggatg aatccgtccc tggggtaaag
     3361 agcatattgt ttttcggccg ggacaaaaac cgattctccc gttgcacggt acaaggagaa
     3421 ccatgccata aagtccatgt tcatgtcgtg ctttcccaat agcaggtcag cagccaactg
     3481 gccccgatta ccggcgctga cagatatgga accattacga acatccaccc cgtctttagt
     3541 aactatatta atcacggctg tcaaagccac actgccataa agcgaagaag ccggtccgcg
     3601 cagcacctct atttgtttga cttttgccag actaatacca taatccggcg aaacagcatt
     3661 agtaatataa ctgttcagac gttgtccatc ctgcataatc aatatgttct cctgttcggg
     3721 agaatatacc ccgcgcatag ccagattcat ctcttcattg gaagacaaac cggatatacc
     3781 gggcacataa gctatcagta catcccgcag gcaccgggca tggatagccc gtatcatctc
     3841 ctccgtaatt aaagtaacag gcaccggagc ttcttccggg gtctctacct gttgtgaggc
     3901 tgtgaccaga gttactttag tctccctgtg tttccttacc atatccgcaa agcgttccgg
     3961 atcttgaagc gagatataat aataaggttc gtctttcaat aacagcgaaa catacttttc
     4021 cgcttccggg aagcggtcta aagctaaaca gcataatgca gccaaacggc acgcctcggt
     4081 atgcatcgta ccttgaaaag acgacagatt ctcctccaag atacgacaag cttcatcgat
     4141 atctccgctc ttataaaatg tttccgcctt tacaaacgaa ttacggatgt tatccgccgg
     4201 ctgagctgac agttgcacaa ccccaaagca gcaaagaata tatagcagac agcgtttcat
     4261 gcgataggaa tgataaaccg gaaacaagta tattcatgca ggaccgaatc aaacaatact
     4321 tttccatggt gtttgttttc tataatatca cgaacgattg ccataccaag gcctgtcccc
     4381 tgccccaccg gttttgttgt gaaaaaagag tcaaatagtt ttcgtttgac ctccggaccc
     4441 atgccctctc cgttatcacg aatagaaagt acaattcttt tatccaactt ttctaaggtc
     4501 accattatct cgggggaata tccttcggga gcattctgcc attttttcca tactgcatag
     4561 caggcattat tcatcacatt caagactgcc cgactgaaat cctgcgggat cagccggatc
     4621 gaggggatat ctttagcata atcttcacgg atagcaatat tgaaattctt ataattggcc
     4681 cgcatggcat gataagccag ccacacatat tctttagtca atttttgtat ttgtgtaggc
     4741 atgaattcgt cttctttccc cctggagtaa agcaaaatac cacggataat gctgatagcc
     4801 cgatcaccat gctctttgat tttgtccaca ttctctctca gcccggaaag tatatctttg
     4861 atatcttcca gttccgcttc cggaatacga gcttttgctt catccaccct atcggccagg
     4921 tcggccaaca attgaccgga cagtttactg aaattgatga caaaattcaa aggattctgt
     4981 atctcgtgtg caatgcctgc actcaacaaa cccaatgatc ccagcttttc ctgctctttg
     5041 agccgtgctt ccaactcttc aattcgtttc tcttgtgaaa tgtttttttc cataatcaat
     5101 ctgttctatg tttatttata ctgacttttc ctcccacaat ggcagagtga tagtgaattc
     5161 tgtcaattca tctttttcag aacgtactgc tatctgccca tggtgattta atatgatttc
     5221 cttactcaga tacaaaccga tacctgctgc ctctccggtt gttttggtag taaagaacgg
     5281 atcgaagatt ttatccagaa tactctgctc gatccccact ccattgtcat ataggcgaat
     5341 gactgcctgt ccgtccttac tttccaatgc caggccaatc tctgccggat aggctttctt
     5401 accgtatttt ttggctatgg catacatacc attgttaaga agactcataa tggtttttcc
     5461 cagttgttcg gcattcccgt caataaacaa cggattatcg ggcaaggaag tacgaaccgc
     5521 aatgtgcata gccgtaatct ccttctgata ataactgctc aatagctcca tgtctttccg
     5581 gcataaaccg attaattctg ttttttccag ttgcctgtta cggtctctca ggatttcttc
     5641 catggccttc agtacacgag tggtgttact tccatgttcc tcaatctttt ccagattatc
     5701 tctcatcatg ttgatgacat ctaccgaatc caagtaggta tcttcatcca aaagttcttt
     5761 tacactctcc agattctgat ataggtcctt cagtaatcct gaggtcaggt gggaaaaatt
     5821 attaatgtaa ttcaacggat tcagaatacg gtcaatcaac ccttgagtca gtttacctac
     5881 agtagccatt ttttcttgtc gaaccaattc atcttgtgcc tggcccagct ccttcaatgc
     5941 tttttccaat tttaaggact tttcctcaat ttcatttttt tgttgtacca actgtttggt
     6001 acgttggccg acaagggcct ctaacctctc cttctctttc agcaaactgc gcattctcca
     6061 tttaaacaat aagaacaaca gcattccaaa agcaacggta tataggatca gacaatacca
     6121 ttgcaaataa aaaggaggca ataacgaaaa gcggaattgt ttcatttcac tctctgtgcc
     6181 gtaaatatca cgggcccgga cacaaaacgt atacgtaccc gacgaaaggt tggcatactc
     6241 tttcacagtc ccggaatccc acgaactcca ttccggatca taaccgacca ggcgatatct
     6301 atactcattg gaaccggtga aacagggcgc atcggtagca aatgaaaaac gaatggaacg
     6361 tacatcattc cccaaacgag gtactgtact atttatctgc cagtccgctc ccccggactc
     6421 ttccggcaga tctcctcccc aatagacaga atcacggttc agacaaactt cacgaagata
     6481 gatgcaggga gcaaccggag taaatgtccg ggccttttca aggtccatcc gaattaaacc
     6541 aaaatcaccg ccgaaccatg ccgccctgtc ttcttcaata taaatcaccc tcacgacata
     6601 attccgaatg gcatacaggc attggttgaa tttctccgta tcaatttgcg aatgatgtac
     6661 ctgtacctct tttcctttca gatttgtctg ccaatgacag ccatcgttgt ccgtatactc
     6721 ggtcattact tcttcactct ctctgtcttg aagtacaaaa gagctttcac cctcttcccg
     6781 caaatagatt tctccgtaca acgttttagc ccatacagaa cgatctttct tcacttccag
     6841 acgaacgact ttttcgacat cggaaatttt ctttatccgt tcctcatctg ccgaatattg
     6901 ataaatccca tccatagtgc ccatcagaag gttcgtatgc ccaatgaatg ccaatgaata
     6961 agctgccata tctgtgagtt tttccgaatg attataatcc cggatcacat acacaccatc
     7021 gccggacgct gcatataatt ctccttgtgg agaaagacac agttgccaac atgcttgcga
     7081 aattccctga acaggaacaa aagtgttttg cttcaatacg tataatccct gtaaggtccc
     7141 gatatatatc attcctttgt aagagacaac cgatattacc tctcccttca gaccttcacc
     7201 agaggtataa cggctgaaca aagagggaat aaaaacatga aacacaccgt tatccgtagc
     7261 tccccagaga ttgccacgcc catcggccgc aatacccgaa acagcgttac tgcataagcc
     7321 atttctctca gttacggaaa accgttcttt tttcccactg tcatccatta ttaatccatg
     7381 ggcagagttt atcgagattg tttctcctcc gggtagagaa aacgcccgat tcattgagac
     7441 tgaggattga tttctccact tttcctgcaa ttgggccgga agtacctgaa ccggtgtcaa
     7501 aatggaatct gactgaaccg tataatatct tcctgatgta gctttcagat aaatgcgttt
     7561 atctatttct gccatatctt ccaattcgcc caaagagtct gtgtccagat cggaaagaag
     7621 ggttctcaac gtaatacatc cgcgtccatc acgctctatc cgtccgaaca cgttatatcc
     7681 tcccacccat atcctacctt ccgaatcacg aaacaaacgg gtgacacggg aaaaacccgg
     7741 tgtataaata gtttcccaac ggttatagtc ataatgaagg ataccttcga aattagcaaa
     7801 atagacattt ccacaactgt cgcaaacgac atcgaaatta cgattgtgcg cctgataaac
     7861 cgaagccgga tagtttacaa aaaacgggat accttcttgt gaatttgcat ataccgagca
     7921 aagacacatt atcaaaaaga ctatcttttt catggctgat acgtttttag gtaataggat
     7981 tcaaatggaa tttgcttacc gatataatac tcccattctt ctcgagtaaa atcacgctgt
     8041 aacccctgac ggacaacagt agccatgtga tcgggtgaaa caggcacccg atacaaccgc
     8101 ccctgttcgt ctcctataaa gacagatgta ccgtccggat gaaagcaaaa agtatggatc
     8161 caaccggggc ttgtcacaat aacggccgac tcggtctttc ctttacgaag atcccacaga
     8221 cgcagcgtac aatcgtaact actcgaaaac agtttgttcc ctttccggga aatagcagta
     8281 accgcagcct gatgccctat caacttctgc cggatatttc cattcttatc acaaatcagg
     8341 atgactcctt cacgacagcc aatggcatat ctttcattgg taagaggaca gaatgcagta
     8401 accacactat tctcgggcaa gctgtctata aatctgagaa atgtaccatc cgacgaaagt
     8461 aaagctactg tcccattctt aaaaaaaaca tagagatagc cttccatttg accgacacaa
     8521 gttatcgaat gttccggctg aaaataaggt tgtatctcat ggttgataca gtcaaaagaa
     8581 taaataccgg ttgtggaaac tgccaatacc aagttagagg caatcgaaat caattgccga
     8641 tattctcctt taggcaaaaa gcgggtaacg ataccggcgg aatccgtgga gataagctgc
     8701 ccgcagtatg acaaggcata catctgtgaa tcggaccgca acagcacatc ccgaaaatca
     8761 taacagggat cattcaacag taattcggag gtataggtct gcccattttc cgatttccaa
     8821 cgtatcatct caccgtactt gccgacagtg accaatcccg gcagaggatt ccgaccggct
     8881 cttgcttttt cctcgcctcc ggataacagt ttgatcccgg taacagctcc tttatgcccg
     8941 aaccaaagct gatcttgcct gcaagacaaa gacaatgcat tgaaaacagc cggatgatat
     9001 acatcgccat catatcgctt ggtaaaccac caggcggtat atgccaacag agaagctaat
     9061 tccatgttgc ccgaccgata ttgagtaaca gagagtgtcc ccaatgaacg tcccaaagcc
     9121 agaaaagcca atgtatcggc aaccctcttc gactgttcgg cctgtagttg ccgttccatc
     9181 gccagattct tttgttcatc tgccatccga tacgctttct cagcctccaa ttgtgcagca
     9241 agcgctcttt cccgtgccaa ctctgcctgc tgttgcattc ggttggcctt ttgagtttgc
     9301 gcaacggctt cctgtcttct cttttcggaa atatcctttt gttgataagc aatctcctcc
     9361 atttgttgac tgacccgttg tataagaacc gatttctttt ctttatcccg gaattcctcc
     9421 agagacagag caagacgctc cctgtccgat gccgaatgac gatatgcccg gtatagaacc
     9481 agacatactg tcaaaagtat acaaggaacg gcaatgatcc aacggattat attttcgttt
     9541 aacttgatca tgatacaggt tcatcagtgg gttgcagata tttcttttta atggtcaacc
     9601 gattctcctt attcacgtac gtatacgcta cgtcatccat catttcacgt accaggaaaa
     9661 tgcccaatcc tcctatttca cgttgttcta acggtaatga aatatcagga tcggctttat
     9721 ccaaaggatt gaatggaata ccaccatcta taaactccaa agtaatctct ccgtcttcat
     9781 cccataagca cagagtcaga taaccttctg cctgctgcgg ataagcgtaa ttgagaatat
     9841 tgacaatgat ctcctcactg accaaacgga tggcataaga cagggaagga tgtgaagcaa
     9901 cttcacgact atgcatcagc atactaagaa tttcatctaa cctcccatcg acagggcgaa
     9961 actgaagtaa cgtcattgct caggtaattt ttagggttgt gataattcat cgagagtctg
    10021 ataaaaacga aagaatttat cgaatccggt catgtgcatc acgtctttaa cctcttgtga
    10081 cacaccgaca aggcaaacat ctctactttt agctttcgcc agcttaaaga cataaagcat
    10141 gactctcaat ccggcactgg atacataaga acagccgctg agatctaatg caacagaatg
    10201 tccttgctcg ataagagcta caatttttgc ttgttcgtca ccgcttgtat ttgaatccaa
    10261 gacggaacct acaaaatgaa tttcatactt ttccatcgtt cttttatttt aatattattt
    10321 gattcgttga agagaaagca gggttatgtc atcggactga ggatagtctc cggagaaagt
    10381 cttaacagac tgcaatacac tcgtaacaac ctcttttgcg gaactacttt cgtgcataga
    10441 cgccaatata tcctgtaagt tactttccga gaattgttcc cgcttgtcgt taaaagcctc
    10501 tgtgacacca tccgtataca gaagtaaagt gtcaccgatg ccgaacgtca atgtattact
    10561 ctcaaattca atatcatcga acacgcctac cacaaaatta gaagcgacag gcaagcattc
    10621 aacagtccgt ccgccgcgaa ggagataagg gggattatgc ccggcattgg tatagtccat
    10681 catgccggtt ttataatgat aaatcccata aaagaccgta acaaacatag agtccaggct
    10741 ctctttacac agtaacttat tggcataagt aaggcattct gccgacgaaa caccccgaag
    10801 agcagttgca cggagcaggg tccgactaac cgccatgaac aaggatgccg gcaccccttt
    10861 cccggatacg tcagcaatca ccagcccgat acgttcatcg tcaatctgga agaaatcata
    10921 aaaatcgcca cctacatctt ttgccggagt catggaagca taaatatcaa ccacttccgt
    10981 cagttccgga aaaggaggaa aggaacgggg aagaatcgtt tgctggattt ctcccgcaat
    11041 agccaggtca tttttgatag attccagttg gttgtgctcc tgctgtgact cacggatata
    11101 gcgaacctgt tcgatcgcct tttcaatagt ccgcgacaga tcatccaaat cgatcggttt
    11161 ggttgcaaaa tcaaacgctc ccttgttcat ggcagaacgt atgttatcca tgtctccata
    11221 agcagagacc attatacact tcattgccgg atttttcagt tcattgacct tagccaatag
    11281 ggtcaaccca tccatctccg gcatattaat atcactcagg atgatatcga aatcgggagt
    11341 ttccagaagt ttctgtaaag cttccaaccc gttatgggca aaagcgaact cgtattcacc
    11401 ttttcgtatt tgtcgcctga agtattgggt aagtaatact tctaaatcga gttcatcatc
    11461 tacactcaat atttttactg ccatatctat tgttatttat gaatttcaac cgtttgttct
    11521 gacgtttatg atggcaaaaa tagagagtga ccgccccggt tacaatttta tattttaaac
    11581 aggaagaatg tttttccgaa tggacgatat tgtcttataa gcatacaggt atattgcttt
    11641 cgtggcttag aagacagcac ctgaaagatt gatttacact cctgaaagaa actattccgt
    11701 attcagaatt tatattttta agatggaact tttcttctca cttttgtcac cgtaagctta
    11761 caaagaataa atagaaacgg cggattccga aaagccgaag aaagagtagg aactttttac
    11821 gaatcactat tatgcttatt attttaaaac aagatgatag ttgtcaagtt gcacaaacga
    11881 catgtacaac aaactcttta gaaatccgat acaaagatta tagtgtactg aaaaaaactc
    11941 tggatttgaa cacaaaatct attaatagcg atagctgtat agagttaatt atttacggaa
    12001 cacacggaaa tgaaaaggaa atttgcaaac taaccaaacc agacataaaa gatctgagct
    12061 atttcttcaa aggaaaagtt tgtagattag ttcttgatgc ttgccatagc gcctgccata
    12121 ttccacattt caaagagatg ttaacagatg atggaatcat attatgtcat gtaggtatct
    12181 gccaagtaaa cagcatcgaa actaaaacag gtaaagacac ctatgaacgg tggataaatg
    12241 gcaataagga aggattaaaa gtatggtcgg atggaatcgt tccagctatc tatactcaaa
    12301 agaataacac tttaacttac tacgaatgta gcaaattcga agtagatatt aatcaccctt
    12361 ttaccggaac tgaatttaag acttattgtc tgaatttaaa at
//
