LOCUS       c00726_gnlPro..        14248 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CKMDKBCG_726.
ACCESSION   c00726_gnlPro..
VERSION     c00726_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 15:26:20
            Original ID  :: gnl|Prokka|CKMDKBCG_726
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14248
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14248
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[36:4248](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      37..4248
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14248
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14248
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             37..4248
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg726_1"
                     /sec_met_domain="HGD-D (E-value: 2.2e-21, bitscore: 67.4,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 6.4e-34, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVRREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLMAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNSENHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSEPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVYKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMIS
                     FGCGPDAFLIDEVRNLLKRYSKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQTK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKSFNYFIPFESIFEKAEKAKQVISLGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
     CDS             4253..4873
                     /locus_tag="ctg726_2"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEE"
     CDS             complement(5063..5245)
                     /locus_tag="ctg726_3"
                     /transl_table=11
                     /translation="MLRGMMDVLTDSASKEMIWQEGDTMYYPEGVTDPDYCVLKFTAIS
                     GRFYSNFKSEDFVVE"
     CDS             5451..5645
                     /locus_tag="ctg726_4"
                     /transl_table=11
                     /translation="MLPTVFSASLIILLFIIGLLSDAKVEKCQESNAIKRKVEIALFTV
                     CVLYDTITEFLPYAVGSYG"
     CDS             complement(5578..6456)
                     /locus_tag="ctg726_5"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLTKSTVHTLNYYD
                     ITFITEGKGAFAVDNQTYEAIPCDVLFSKPGEIRNWDIHHIINGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKMEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMISMEEGRSREVFNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGFSAKQYIQGKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGE
                     TPLLYRKAHKP"
     CDS             complement(6580..7128)
                     /locus_tag="ctg726_6"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATMPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGADVTSLGYLVGSSK"
     CDS             complement(7169..8533)
                     /locus_tag="ctg726_7"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIATGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHSRIAELMHTPVEAMVDTKNYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLRGTMMPAMSN"
     CDS             complement(8771..10351)
                     /locus_tag="ctg726_8"
                     /transl_table=11
                     /translation="LNEIEMKNEGSLLSFRRIYYRGKLNSCNYTCSYCPFGKKSHLADT
                     TQDEQAWNRFIAAIEQWKGEPLQLFIIPYGEALIHRYYRKGMMHLAALPQVAGISCQTN
                     LSFPAKHWLDEIRVAPTVISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCAGAVGN
                     PSAKAVLNDLRNALLPDIYLFINAMQGLRAPLSQEDIQFFSQLDNLFEYDLKNAPAQWE
                     VCAGGRDNCFIDWKGDMYACPRSRVKIGNFYQGDGAVVPLSCKRKVCDCYIAFSNLNNH
                     PLHRIMGEGAFWRIPDKPLITTVFFDVDGTLTDSQGKVPESYANALRYMAQSVSLYLAT
                     SLSMEQAKKKLGKALFDLFRGGVFADGGLLSYSRQIKCLPVKVYPEVYGESSKVTIHSY
                     EGVVYKYSILVRDKEQRESILTRLKENPCQVFHKAPLITVIHPEASKKEGVLQLCKALG
                     LASEHTLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKERARYTLNPDRLAAFFRFSNGDP
                     IDQTSSDNS"
     CDS             complement(10348..11625)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg726_9"
                     /sec_met_domain="Radical_SAM (E-value: 1.5e-16, bitscore:
                     51.7, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPLPRYVDYMYSYPHKTAYRSFPSPVSLVPYLKQVEGQKASLY
                     FHIPFCSHKCGYCNLFSLQTNRADYIATYLETLHKQAQQLSPLTTGLAFDSFAIGGGTP
                     LLLTVPQLEYLLDTAALFGVHPSHTFTSVETSPEYADPARLDLLKQAGVARVSIGVQSF
                     LDEELTALKRRPRRDMINQALEAIRKRQFPFFNIDLIYGIKGQTVASFLYSLEQALLFQ
                     PNELFIYPLYVRPGTAITERESDDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSADAE
                     ISCGDEVMLSCGSGGRSYLGNLHYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQ
                     EEQRQRFIIKNLMYYMGLDKAEYERRFGESPDNVPLFRQLAERQWIENTDNGRICLTFD
                     GMAYSDYIGQLFITPEIRELMETYSY"
     CDS             complement(11622..12476)
                     /locus_tag="ctg726_10"
                     /transl_table=11
                     /translation="MQIDELPAGEQTQNPDLDMNQVVGTHDILMLCFDTLRYDVSKEEE
                     EAGRTPVLNSHGGEWEKRHAPGNFTYPSHFAIFAGFLPSPAEPHSLRSRKWLFFPVQAG
                     TGRIPPAGSYPFTEATFVQSLANVGYETICIGGVNFFSKRNELGRVFPGYFTKSYWLPT
                     FGCTAPDSTEKQIDFALKKLENYPEDKRIFMYINFSAIHYPNCHYVEGKMKDDKESHAA
                     ALQYVDSQLPRLFQAFQKRGNTLVIALSDHGTCYGEDGYEYHCISHETVYTVPYKHFIL
                     TKK"
     CDS             complement(12463..13473)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg726_11"
                     /sec_met_domain="ATP-grasp_3 (E-value: 6.1e-09, bitscore:
                     26.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIVVSNFLSKRIEYFIEAGKHLQVEVRFMTYGELFNCLPQLRQ
                     AVIKLEPCVSDETNFLKYALLNQAYKETLQRLGEMRLSDDVCFLNTPHALLRALDKKET
                     KQVLMDRGLKVTPMLPSPRSFDELRELLTGCGRGCFLKPRYGSGAGGVMAIRYQPNRNK
                     WVVYTTLQQVDGVIHNTKRIHRLSTEKEMIPLAEAVMQTEAILEEWIPKEQLQGENYDL
                     RVVCRESEIDYIVVRCSKGSITNLHLNNKAHWWNELSLPEVVRQQIYFQCQEAVQSLDL
                     QYAGVDVLIERGTDIPYIIEVNGQGDHVYQDMFAHNSIYIQQIKNIKKRYNHANR"
ORIGIN
        1 tgtcaaacac gaggtctaat ttaagatatt tggtatatga atgtatataa agtgggttta
       61 gatataggct ctactaccac taagatggta gtattggata aagatggaac tacagtcttg
      121 ttttccggat acaaaaggca tcaggcaaaa atacaagaat gtttactcgg atttctttat
      181 caaataaagg aacagttggg tgatattcct ttatctttcc atattacggg ctctgttgga
      241 atgggaattt cagagaaatg ctctctgccg tttgtgcaag aggttgtagc tgcaacaaac
      301 tatgtgcgcc gggagcatcc gcacacagcc actatgatcg atattggagg agaagatgcg
      361 aaagttgttt tctttcagga cggacaggct acagacctgc gcatgaatgg aaattgcgcc
      421 ggcggaaccg gggctttcat tgaccagatg gctattctgc ttggagtctc catcgacgaa
      481 ttgaatgaac tagcacttcg ttccaatcag gtatactcta tcgcttcacg ctgcggagta
      541 ttctgcaaaa cggacataca gaatctgatg gccaaaaata tatctaaaga aaatatagca
      601 gcttccattt tccatgcagt agccgtacag accactgtca cacttgcacg cggttgcaat
      661 atcgtagctc cggtattact ctgcggtggc ccattgactt ttattccggc ccttcggaaa
      721 gcatttgcca actatctgaa tctgtcacaa gatacagatt tcatattacc ggaaaaagga
      781 aatctgatcc ctgcctgggg agcagcattg gcagagaaca atgaagaaag tattcatctc
      841 tccaacctga tacaggtaat agaaaacaaa ctaagtgtta cctcaccttt ccagagtgat
      901 ctttctccta tattcgacag tgaggaagaa tatcggtcat ggaaaaaaga aaaagaccag
      961 tataaaattc aatatgccag tctgcgtccc ggattacagg aagcaactat cggcatagac
     1021 tccggctcta ctaccaccaa aatcgtagta ctcgacaaca atcatcgtat cctttactcc
     1081 tattatcacg acaacaacgg aaaccctata aaaacagtag agaacggctt gcagaaacta
     1141 tatgaagaat gccggagacg aggaactacc ctgcgcataa aaggaggatg ttctaccggt
     1201 tacggagaag atctgataaa agcggctttc cacatggatg cgggaatcat tgaaaccatc
     1261 gctcattatg ctgctgccaa acatatcagc aaagaagttt cttttatcct ggatattgga
     1321 ggacaggata tgaaagccat ctttgtgaac gacggagtaa tcaacagaat cgaaatcaat
     1381 gaagcctgtt cctccggttg cggttctttt atcagcacat ttgcgcaatc gctggattac
     1441 agtgtggagg actttgccaa agcagcttgt ttttcgcaag caccatgtga tctgggtaca
     1501 cgttgcacag tcttcatgaa ctccaaagta aaacaggtac ttcgggaagg agcgtccgta
     1561 gcggatatag ctgccggatt atcttattcc gttgttaaaa actgcctgta taaggttctg
     1621 caattaaaag acacggagat acttggcgac catattgtcg tgcagggagg aaccatgcgt
     1681 aatgattcca tcgtacgaag tctggaaaag ctgaccggga aacaaacctt ccgcagtaac
     1741 tgtcctgaat tgatgggtgc tcttggttgt gccctatatg ccaaacaaat cgaaaatgcc
     1801 cgggtgacgg agctgaacga gatgctccaa tgggcacaat atacttccaa gcaacttcaa
     1861 tgccgggggt gcgagaacca gtgcgccatc atgcgatata cgttcaacag tgaaaaccat
     1921 tacttctccg gcaaccggtg tgagaaggtg ttttccaata aaggaagcca tgcggacaaa
     1981 ggcatcaata cgtatgataa aaagctggaa ttattattcg accggagcgc agatattcca
     2041 caacccctat tcaccatagg tattccacgt attctgaaca tgtatgagga ataccctttc
     2101 tggcatacct tatttactgc ttgtggcatt caggtacagt tgtcggaacc ctctacattc
     2161 agcaaatacg agactgctgc cggcatggtg atgtctgata acatctgctt ccctgccaaa
     2221 cttgtgcaca gtcatatccg taacctgaca ctgcaaaacg tcaaccggat atttatgccg
     2281 ttcgttgttt tcgagaaaaa ggataagcaa cagcaaaaca gctataattg ccccatcgtt
     2341 tccggttatt cggaagtcat caaaagtgta caggaagaga atataccgat agatgctccg
     2401 actatcacct tcaaagatga agcattgctg tataaacaat gctatgaata tctgaaatct
     2461 ttgggtatca gggatgaggt atacaaaaat gccttctcac gcgcattaca ggaacaatat
     2521 gctttcgaag aaaaaattgc tgcctataat caggaagttc tgaacgaggg acgggaaaaa
     2581 cacaaactga ttatcttact cgccggacgc ccttaccata gcgatccact gatacagcac
     2641 aaggtttcgg acatgattgc tgcgatggga gtttatgtga taactgatga tattgtccgc
     2701 cagcaggaga tttcattgga aaagactcat tacctctctc aatgggcatt taccaaccgt
     2761 attctgaaag caaccaagtg ggcggcaatg caagagggtg acatacaata tatgcagatg
     2821 atttcttttg gctgcggtcc ggatgctttc cttatagatg aagtacgtaa cttactgaag
     2881 cgatacagca agaatcttac tttgctcaag atagacgatg ttaataatat cggctccatc
     2941 aaattacgag tccgctcgtt ggtggaaagc ttgaatttca gtttgaaaca ttctcaaacg
     3001 aaagatcccg agccatttgt ttcaactgct cctttcacca agaaagacaa aaagaagaaa
     3061 atcctcgctc cattttttac gcctttcatc tcaccactca ttccgtccat catgaaagtg
     3121 gccggatatg aaatggagac tttaccgttg agcgacaccg catcatgcga ctggggattg
     3181 aaatactcca ataatgaagt atgttatccg gcaacattga ttgtcggcga catagtaaaa
     3241 gcctttaaaa gcggacgtta tgatcctgcc aatacgtgcg ttgccatcac gcaaaccggt
     3301 ggacaatgtc gtgccagcaa ctatatttca ctgataaaaa aggcattgat tgagaatgga
     3361 tacaccaata caccggtggt atcacttgct ttcggcagtg gtatcgaaaa tgagcaatcc
     3421 ggttttaagg taaactggct caaggtttta ccaatcatac ttgcgtctgt gttatacagt
     3481 gattgcattg ccaaattcta ttatgcagct gtcgttcgtg agaaagaacg gggacaggcc
     3541 gcccgtctgc gcgatcttta tctggataca gcacagccca tcatccagaa aaataaaccg
     3601 gaggacttgt tgagctactt atatctcgct gccagagact tcaacaaaat ctgtgaacag
     3661 agatcctgtc acaaagtagg tattgttggg gaaatattcc tgaagttcaa cccttttgct
     3721 caaaaggacg tcacctcatg gctcatcaac cagaagatcg aagtgattcc gccactgata
     3781 agtgatttct tcatgcaggg atttgtcaac ctgaaagtga gacagaacca acacttgcag
     3841 cgaaaactca ctcccgactt tgttatcgac tggttataca agaaagtcca gaagcagatt
     3901 aataaagtga atgaaatcgg caaaagtttc aattacttca taccgttcga atctatcttt
     3961 gaaaaggcag aaaaagctaa acaagtcatc tccttgggca cccagtttgg agagggttgg
     4021 ctgatatccg gtgaaatact atcctttgct tcccaaggag tcaatcatgt cattagcttg
     4081 caacctttcg gatgcattgc caatcacatt gtagaaaaag gaatagaaaa acgtataaaa
     4141 tcgctgtgcc ctcaaatgaa tatactatct ttagactttg acagtagcgt cagcgatgtg
     4201 aacataacaa acagattatt actttttatt gacaacataa acaactaaaa ttatggctac
     4261 aacggaacat agcgatttag agcagcaaat aataaaaact gcccaacaac ttttcataga
     4321 aaaaggattt gtggagacca gcatgagtga tattgctgca acggtaggaa tcaaccggcc
     4381 cactttacat tattatttca gaaccaaaga taagatgttc aaagccgtgt tcggctcgat
     4441 agtcatgtct ttaatgccga aaatacagga tatagtaaaa caggatatcc catttatgga
     4501 gcgactaagc atgattctgg atgagtatat tgagcttttc acaagtaatc cctgtcttcc
     4561 cagattcatt tgtggggaaa tacagcgtga tgtaaaccac ttgcttgcca ctgcaaaaga
     4621 acttcagttc ggagatgctt tatcccaagt gaaagacagt atactgacag caatggaaga
     4681 cggtaaactt aaaaaggttc cgatacatat tgtatttctg actgtctaca gcctattgag
     4741 ctatccattt cttgccaaga acctgatagt atctttattc ttggaagatg aagccgcttt
     4801 tgctgacttc ctgcaagaat ggaaacaaaa catcatcaac caattgcaga acttattgtg
     4861 ttatgaggaa tagtatagat actatataag gaggtgtgtc ataatgaata ataaaacgca
     4921 gattaacgca aattatcgca gattattcca attatattga tatattaatc aacgacttat
     4981 aaaattattt ctgcgataat ttgcgttaat ctgcgttttg acacactccg ttattaccat
     5041 tccaatcacc ccatcttgca ccttattcga ccacaaaatc ttccgattta aaattactat
     5101 agaaacgtcc tgaaatagca gtaaacttca atacacagta atcgggatcc gtcactccct
     5161 ccggataata catggtatct ccctcctgcc agatcatctc tttactggca ctatccgtca
     5221 agacgtccat cataccgcgt agcatgaccc ctctaaagaa tctcgtatcg cagaagtaga
     5281 tacatgcatg gttgttctcc cggtattgcg ccacacgcat ggacgaagta tttgttgtca
     5341 gataaatcgt ttttatcccc tctctttttc tgggttgcag cattgctttg atggtaggaa
     5401 atccttcacc gtctatcgaa ccgataaaag ctgttttcag cttatcaatc atgttgccta
     5461 ctgttttttc cgcgtctctc atcattttac tttttattat tggtttatta tctgatgcga
     5521 aagtagagaa atgccaggaa agcaatgcaa taaaaagaaa ggtagaaata gcacttttta
     5581 cggtttgtgt gctttacgat acaataacgg agtttctccc gtatgctgtc ggaagctacg
     5641 gataaaataa gaaaccgttg aaaaacagag ttcaaatgca atatcagcta taggaaagtc
     5701 cgtataaaca agcagcctct tggcctcttc catcaccttg ccctgaatat attgttttgc
     5761 gctgaacccc atggtcgagg ttatcatctc attgagatag ttaggagtaa tgcagagctt
     5821 atccgcataa tattgaaccg aatgttgctc ttttgcatgt gtcgcaacca aattcatgaa
     5881 tttacttaca tgattattga aaacttccct acttctgccc tcctccatcg aaatcatttt
     5941 aagataagca cgatccagca acatcaggac ttcataaagc aatgctctca aaacgtgtac
     6001 atcgccctgt tgatacgaat caatctccat ctttatatca tgcaaggttt caagtatgcg
     6061 tgtataaagc tcatcagaca aatgtagtag cgatgaagaa ctttctatct gaaaaaacga
     6121 aagatgctgt acaaacaaag aatctttaaa gaggaaagac aaaaactctt cttcgaaaat
     6181 cagagcatac ccattgatga tatgatgaat atcccagttc cggatttccc ccggtttaga
     6241 aaaaaggacg tcacatggaa ttgcttcata ggtttggtta tcgactgcaa aagctccctt
     6301 accttctgtt ataaaagtaa tatcataata atttagagtg tggacagtac ttttagtcag
     6361 gaacttcttc acatacttca gttctactac atcgaccaaa agttcactcc catacttatg
     6421 cttataaaaa gtatatcgag gtattgagtt tttcattcag aatacaaaaa tagtattcct
     6481 taccaaataa tccaaagact tttcaaattc gattcgattg aataagccat gaaccatctg
     6541 ataaggaata catagaaaaa tatgtctagg ttatatttcc tatttagaac ttccgaccag
     6601 atatcccaaa ctggtcacat ctgcccccaa gtaatgatta atgtgcttca atggcaccct
     6661 gtacagaata tctggaattt ccgccaataa agagaggtac ctttccctta ctgtcagctt
     6721 gcgggcattc atatcctctt cctctttaaa gtaaaactga tactccatca gttgacggac
     6781 cagattcgca aatgaaattg aagatgcaca caactcttca atctcctctt cactgatgta
     6841 ataagcagca catttcgtca gtgtcttgat agaatactga cttgaattat agcataacac
     6901 agcatcaccc gcagagaaaa accgattggt tctctcttct ccttcatgag tggtatatgt
     6961 atgcaaaata ccggaaacaa taatgtacaa gctctgctct ggcattgtgg cagaagcaat
     7021 cgtttctcct ttatccagat acaccatttc cattcgagcc aacagctctt tcacttctct
     7081 ttcatccacc tgatactcaa aacagagttt cttcaaataa gcttccatac aaaatagatt
     7141 ttagttaata tatgtcactt aaaaacacct aattcgacat agcaggcatc attgtgcctc
     7201 tcaaatataa tttcctttgg gtatatcgta aataccagat acagatcaat aatgaaacga
     7261 ccgttgaaat gggtggagca aatcccatga taaacagcga cgagctatct atctggctga
     7321 accagtatga caacggtata cggaacagga aagtggctat cagactgtga atcatcggga
     7381 ataacgagtt tccttgtccg ctgaaataag aattaatgca gaacacgaaa ctaaccacga
     7441 tgcagtcgat gctataccct cgcaaataat ctgccgccat tgccaccaca gcagcatctt
     7501 tcgtaaagaa agcagtaaga gtctccggca ggaattgcga atacacgcaa accgacacac
     7561 cgaaaacaag agcaatccca atccccgaag ccagacattt attcattctc ttgataagtc
     7621 ccgctccata gttctgtgca gtcatggttg ccacagccga tgatatagcc atcggaggca
     7681 gcatagcaaa cacgatgatt ttctcaacaa cacccaggga agcagatgca atgactccca
     7741 tctgattgac aatgacagtg ataatcagaa aagaaacatt gattaaagca tcctgcaaag
     7801 caataggtgc tcccaacacc aagatctttt tagacagatt ccggttcaat cgaatatctt
     7861 tccgtgaaaa gtcaaaatgg aatccgtgcc ggtataagaa ccagagcgct attccaaagc
     7921 tgactccttg tgcagttaca gtagcgatag ccgctcccgt agccccccaa tggaaataac
     7981 cgaccaatat aaaatcgagc actatattta tcacacatgc cagcccaaca aaataaagtg
     8041 gtgttttaga atcacccaat ccacgcaaaa taccacatac aacattatat cctactataa
     8101 acagaatacc cagagagcat accaaaatat aatttttcgt atctaccatc gcttcgacag
     8161 gagtatgcat cagttctgct atccgactat gaaaaagcac catgaccaaa gttagcacta
     8221 cgccggttat tgaaaacaac catacggaag acccgatagt aaaagctact tttcgattgt
     8281 ctttagctcc ggtagcaata gcaatcagca ctgttgtccc ggtagtaata cccagaataa
     8341 tacctgtaat tgtctgcatc acctgactac caatagctac ggctgccaca cttgccgaat
     8401 catcatattg tccgacaacg aaaaggtcag ctccgccata aagtgcctgg agcacattgg
     8461 caatcagaaa aggtactgca aactgcaaca ataccttcgg tacgcttcct tgtgtcaaat
     8521 ctaactcttt catagtttct tcgatacttt tcctctttat cttattttgt tacaacataa
     8581 aaaaagtgcc ggacaagcga atgatttgca ccattcatct tatccagcac tataattatt
     8641 attatagcac cctccgatga ggatttttat gcctgtccct atttcagggc tgcaaatatg
     8701 ggctttgttt tcataattac caaattttaa ccggttttta ttttcttatg aagatgtaac
     8761 tagctatata tcaactatta tcagacgagg tttggtctat aggatctccg ttagaaaaac
     8821 gaaagaaagc tgccaaccga tccggattca gcgtataacg tgcgcgttct tttaataagg
     8881 gttccgcatt cattacggca caagaatgag aaaccacgga catcatcggc cagtccttta
     8941 acgaatttcc tacaactaaa gtgtgttcag aagctaaacc caaagcctta cataactgaa
     9001 gcaccccctc ttttttactc gcttcaggat gaatgactgt tatcagcgga gctttatgaa
     9061 agacctggca gggattttct ttcaaccggg taagaataga ttctctctgt tctttatcac
     9121 gtaccaatat actatacttg taaaccactc cttcataact atgaatagta acttttgacg
     9181 attctccata tacctccgga tatactttca ccggcaaaca cttaatctgc cgcgaataag
     9241 ataataaacc tccatctgca aacactcctc ccctgaataa atcgaaaaga gcctttccca
     9301 gctttttctt cgcctgctcc atcgacagag aagtggcaag atataaggaa acggactgtg
     9361 ccatatatcg caaagcgtta gcataacttt ctggaacttt tccctgtgaa tcagtcagtg
     9421 ttccatccac atcgaagaaa acagtcgtaa taagtggctt gtccggtatt cgccagaatg
     9481 ccccttctcc cattattcga tgtaaagggt gattgttcag gttactaaat gcaatataac
     9541 agtcacaaac cttcctcttg caagataacg gcacaacagc tccatcacct tgataaaaat
     9601 tacctatctt cacccggctt cggggacaag catacatatc ccctttccaa tcgataaaac
     9661 aattatccct tcctcctgcg caaacttccc attgtgccgg agcattcttc aagtcatact
     9721 caaaaagatt atccagttga ctgaaaaact gaatatcttc ctgacttaat ggtgccctta
     9781 acccttgcat agcattaatg aataaataaa tatccggtaa aagagcattc cgtaaatcat
     9841 taagtacagc ctttgcagag ggatttccta ccgctccggc acatacctgt attcccgcat
     9901 gatggagtat atgaatctga tgcgcaaatt tctctaccga agtcatctca ggatgaaaac
     9961 tagcccaaag ccttatctta cttatcacag tgggagccac acgaatctca tcaagccagt
    10021 gtttagccgg aaaagaaagg ttagtctgac aggaaattcc agccacctgt ggcaatgctg
    10081 ccaaatgcat cattcctttc cgataataac gatggatcaa tgcttcaccg taaggaataa
    10141 taaataactg caacggctcc cctttccatt gttcaatagc tgctataaaa cgattccatg
    10201 cctgttcatc ctgtgtcgta tctgccagat gcgacttttt gccgaaagga caataagaac
    10261 aggtatagtt gcagctattc aatttgccgc gataatatat acgcctgaag gaaagtaaag
    10321 agccttcgtt tttcatttct atttcgttca ataagaataa gtttccatca gttctcttat
    10381 ttcaggagta atgaacaact gaccaatata atcggagtat gccattccgt cgaaagtcag
    10441 acaaatacga ccgttatccg tattttctat ccattgccgt tcagctaact gtcgaaacaa
    10501 cggcacatta tccggtgatt ctccaaaacg acgctcatat tcggccttat caagccccat
    10561 ataatacatc agatttttaa tgataaaacg ttgccgctgt tcttcctgcg aaagaataaa
    10621 tccattacga gccactgtaa aatcagtagt gcccatataa tcatctatct ctccggcaat
    10681 acaacgctga caaacagtat agcgggtggc ataatgcaaa ttaccgaggt aactgcgtcc
    10741 gccggagcca cacgatagca tcacttcatc cccacatgag atttccgcat cagcagacgg
    10801 atgatgaata aaacgtcgca tcgaagtttg tagaaaacct ctgtctttca acaaatcaca
    10861 agcggcacaa tacatctgaa aacagacatc gtcggattcc cgctccgtga tagccgttcc
    10921 cggtcgcaca tatagcggat agataaagag ttcgttaggc tgaaacagaa gagcctgttc
    10981 caatgaataa agaaagctgg ccacagtttg tcctttgatt ccgtaaatca aatcaatatt
    11041 aaaaaacggg aattgtctct tccgaatagc ctccagcgcc tgattaatca tgtctcgccg
    11101 gggacgtctt ttcaaagcag ttaattcttc gtcaaggaaa ctctgtacgc caatactcac
    11161 acgagccact cctgcttgct tcaataagtc caaacgggca ggatcggcat attccggcga
    11221 tgtttctacg gaagtaaagg tatgtgaagg atgcactccg aataaggcag ctgtatccag
    11281 taagtattcc agttgaggaa cagtgaggag caacggtgtg cctcctccaa tggcgaaact
    11341 atcaaatgcc agtccggtag tgagtggaga caactgttgc gcctgcttgt gaagagtttc
    11401 caaataagtt gcgatataat ccgcacgatt tgtttgcaga gaaaacaggt tgcaatatcc
    11461 acatttatga ctacaaaaag gaatatggaa ataaagcgat gctttctgtc cttccacctg
    11521 tttcaggtaa ggaaccagcg aaaccgggga cggaaaagaa cgataagcag ttttatgtgg
    11581 ataactatac atatagtcta catatcgtgg tagcggttga ttcatttttt cgttaaaata
    11641 aagtgtttgt aagggactgt ataaaccgtt tcgtgagata tgcaatgata ttcatatcca
    11701 tcctctccat agcaagtgcc atgatcggaa agagcaatca ccagcgtatt tccccgcttc
    11761 tgaaaggcct gaaataaacg gggtagctga ctgtcgacat attgcagcgc ggcagcgtgt
    11821 gattccttat catccttcat tttgccttcc acataatgac agttcggata atgaatagca
    11881 gaaaaattga tatacataaa aatccgtttg tcctccggat agttttcgag tttcttcaat
    11941 gcaaaatcaa tttgtttttc agtactatcg ggtgccgtgc atccaaaggt cggcagccaa
    12001 taacttttag taaagtaacc gggaaacaca cgccccagtt cattacgctt gctgaagaag
    12061 ttcacccctc ctatacaaat cgtttcataa cctacattgg caaggctttg cacaaaagtt
    12121 gcttccgtaa acggataact tcccgcaggc ggaatacgtc ccgtaccagc ttgcacaggg
    12181 aaaaacaacc acttacggct gcgtagcgaa tgaggttccg ccggagaagg cagaaatcct
    12241 gcaaagatgg caaaatgaga cgggtaagta aaatttcccg gcgcatgtct tttttcccat
    12301 tctcctccgt gactgttcag taccggtgtt cttcctgcct cttcttcctc cttgctgaca
    12361 tcataacgca aggtatcaaa gcaaagcatc aatatatcat gagtacccac cacctgattc
    12421 atatccagat ccggattttg ggtctgttcg ccagccggca gttcatctat ttgcatggtt
    12481 atatctcttt tttatgtttt ttatctgttg aatataaata gaattatgag caaacatatc
    12541 ctgatacaca tgatctccct gtccgttgac ttctattata taaggaatat ctgttcctct
    12601 ctctatcagt acatccactc cggcatattg caaatccaaa gattgaaccg cttcctgaca
    12661 ctgaaaatag atttgttgcc gcactacttc cggcaaagac aattcgttcc accaatgtgc
    12721 cttattgttc agatgcagat tggttatgct tcctttactg catctcacaa cgatataatc
    12781 aatttcagat tcccggcaca ctacacgaag atcataattc tctccctgca actgctcttt
    12841 aggaatccat tcttctaaaa tagcttctgt ttgcatcaca gcttccgcca acgggatcat
    12901 ctctttttcc gtactcaaac ggtggatacg tttagtgtta tgaatgactc catccacttg
    12961 ttgcaaggta gtatagacta cccatttatt ccggttgggt tgatagcgaa tagccataac
    13021 gcctcccgcc cccgaaccgt aacggggttt taaaaagcat cctctcccgc aaccggtaag
    13081 aagctctctc aactcatcaa aagaacgggg agaaggtaac atcggagtca ctttcaaccc
    13141 tctgtccatc aacacttgtt tagtttcctt tttatcaaga gcacgtaata aagcatgggg
    13201 agtattcaaa aagcacacgt catcagataa cctcatctcg cctaaacgtt gcagtgtctc
    13261 cttatatgcc tgattcaaca gcgcatattt caggaaattc gtttcatcgc ttacacaagg
    13321 ttccagtttg ataactgcct gccgtagttg cggcaagcag ttaaaaagtt ccccgtaagt
    13381 cataaaacga acttccacct gcaagtgttt gcctgcttca ataaagtatt ctatacgttt
    13441 ggacagaaag ttgctgacaa cgattatctg catctcctat tctgtaatca tcgggtaata
    13501 ccacaattca ccatcatatt catctgcctc ttcagtttca gcaatatcta ttttcatagg
    13561 gagactctgc aactgtttct tcatctcctt gctcaaataa ttatagcgca tattgataaa
    13621 cttcaaatga gcgatcttat ccatattatc cagcaataat tgggcacctt catctttgag
    13681 agtaccagcc gaaacatcca ttgtttcaag ttggggaaga atatccgact ccaggaacat
    13741 ttctacaatc ttgtcctgtt cttcagagtt gacgatcccc agataagtca gcttcgggaa
    13801 acgttctttg gagaacaacg gacggaatat ctcaatatca gcttcaaatc cataatcttc
    13861 cacaccaaca tatagaatca gtttttccag attggggaaa tcagaaccaa gaatatcttc
    13921 taccacttcg gtaggcaggc caccactgat aatttcgagt gaccgcaact ccggccgtga
    13981 agtctttccc aaacgcagat tattggttcc tttgattttc agatctttca atttaggcat
    14041 ggcatcgagc agcggactaa tatcagcttg ttcaatccat gaaatctcct gttcttcctg
    14101 ctcaatatct ccccagaaca agccttctat ttgtgcgaac ttctccttat tttcaatcat
    14161 tccctgtaat aaggcagaac agtcgccacc ctcataatcc caacaaccga ttgttatttg
    14221 tttatattca gagagatgtt tatctttc
//
