LOCUS       c01004_gnlPro..        14537 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CKMDKBCG_1004.
ACCESSION   c01004_gnlPro..
VERSION     c01004_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 15:26:20
            Original ID  :: gnl|Prokka|CKMDKBCG_1004
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14537
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1971)
                     /locus_tag="ctg1004_1"
                     /transl_table=11
                     /translation="MVYDVTMLEAFYAAYKGKVEHVRAILKRPLTLAEKILYAHLYDVA
                     DLKDYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKDQVAVPSTVHCDHLIQAYKGA
                     KADIATARLTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPKIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTESLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     CVVDWAESVGADLRADDIVTNEPSNYYDRVIEIDLSELEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLAKQVTEKNLSVASPLIVNPGSEQIRA
                     TAERDGMIEAFERLGATIMANACGPCIGQWKRETDDPTRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLVNHNGEKVKLSEPVGDELPLKGFEQGNEG
                     YIAPHGAKTEIKVKPDSQRLQLLTPFPAWDGQDLLNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNSVWNRSTNTYGTVSGTAKMYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRV"
     protocluster    1..14537
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6276:12370]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6277..12370
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14537
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14537
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2038..3975
                     /locus_tag="ctg1004_2"
                     /transl_table=11
                     /translation="MKYFFYPERRFVTFAPIMSNNPKSPIIDLQQQQLLLRMEYEYEKE
                     EFKRQTETMGVARKVKRGLCWYPVSLGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFHQSFEGKVKYMDFIATVSFADEERMVVVLPGAGALAELQTDGILGVQLYFDETSYR
                     AMFEALEDTIRAKDNRLAELRDILLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VSIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSSTYERRFESHPAYPELWGIRKSIREMGSRMRRGSSSEREGMRNRMSRLR
                     DRATELEIQINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEASRGGLDHTLMEKVVQQKPSAVSLLKVQYRMHETIMQ
                     FPSDWFYHGELEAAPEVRYRGILDFDTPMNWIDTSEMDFHEDFVGESFGRINKQEANLL
                     LQELETYIERIGKKRILDERIDFGLISPYKAQVQYLRGKIKGSSFLRPFRSLITVNTVD
                     GFQGQERDVIFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDASTLAKHPFYK
                     RLMLFIKKED"
     CDS             complement(4120..6081)
                     /locus_tag="ctg1004_3"
                     /transl_table=11
                     /translation="MYFNLPKRMINITKLVCVIGVVSVAFSSCLQKDVYDPANSGDKEE
                     EVTLDNYFDFATTKNIQLNIDYGKECPRAYFEVYAENPLSYVAEGGQIIKKAGVSHIAT
                     GFTDIQGRYIKPASFPTAVSEVYIYSPDFGVPTLYKTKVVGSDVSAKITFENALDVTPV
                     DSSTRGAQTRAAVKFITDVIPNVLGTWNANSGKPDYLDASKKINVDATLKSYITTYFPE
                     GKNNVGPLVTDNADILIKEDANVVINYFGGDTGAKSVFAYYCYPKDASTDEIRKATKHA
                     CVIFPNAHGNSLGYYSGVAVNLKYINETGNFPQKDPERIPANTKIGFLIWNNGWVNAKA
                     NGNMFYSTKSLNSDKISHTAIFAAKNKAGDRVNVITMEDWKNGENDYNDVAFVISSNPI
                     AAIEVPDVPNPGDRQGTEMYSGVLGFEDNWPEQGDYDLNDVVMKYQSSVDYNIDNKVLN
                     IIDKFTLAWTGANYKNSFAYEVPFDLSKASKVTVNGSEASSYSGNVITLFKDAKAELGV
                     SNVNAEDMINQNIQEKTYTVSIQFNNPTLDKAVVVAPYNPFIKVFNSATEVHLTDHKPT
                     TGANNRFPSGADISRGDVDGTYFICKDGFPFAIHVDARLDASILNLDLKKENQRIDKTY
                     PKFAEWAKTRDPQIKWWK"
     CDS             complement(6277..7320)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1004_4"
                     /sec_met_domain="IlvN (E-value: 1.2e-46, bitscore: 147.7,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 6.6e-42, bitscore: 132.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTTETVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQREGKTYDKAVADGWVPGETLFGIEEACERGTIVMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHSPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYNSVKTGNEAQISIDSNSQPDYREKLNEELRQLRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(7388..8131)
                     /locus_tag="ctg1004_5"
                     /transl_table=11
                     /translation="MSEENRIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHANDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYENFSVQTWVENVYRLFTDRNFAIIDKDGK
                     KIGYARSVWAMINLNTRKPADLLTLHGGSIVDYVCDEPCPIEKPSRIKVTSDQPIATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYKTKRIRRFEMAYVAESYFGDELSFFCDEV
                     NANEFHVEVKKNGNEVVCRSKVIFE"
     CDS             complement(8137..8694)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1004_6"
                     /sec_met_domain="ALS_ss_C (E-value: 2e-19, bitscore: 59.1,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDIIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQENP
                     EASKLIRRYNARIVEVNPVFSIVEKNGMSEDITSLYGELKALNCVLQFVRSGRVAITTS
                     CFERVNEFLDGREAMYNQSKNQ"
     CDS             complement(8752..10446)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1004_7"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.1e-48, bitscore:
                     152.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDLITGAEALMRSLEHQGVTTIFGYPGGSIMPVFDALYDHQNIL
                     NHILVRHEQGAAHAAQGYARVSGDVGVCLVTSGPGATNTVTGIADAMIDSTPIVVIAGQ
                     VGTGFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIARSGRPGPVVLDF
                     AKNAQVEKTKYEPTKVDFIRSYVPVPDTDEETVQAAAELINNAERPLVLVGQGVELGNA
                     QSELREFIEKADMPAGCTLLGLSALPTEHPLNKGMLGMHGNLGPNINTNKCDVLIAVGM
                     RFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDVAVLGDCKETLASVTKLLKKNTH
                     TEWIDSFKEYEKVEEEKVIRPELHPATNSLSMGEVVRAVSDATHHEAVLVTDVGQNQMI
                     SARYFKYTKERSIITSGGLGTMGFGLPAAIGATFGAPERTVCVFMGDGGLQMNIQELGT
                     IMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKVASAYDIPSKRVFT
                     REELKEAIAEMLATDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             complement(10571..12370)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1004_8"
                     /sec_met_domain="ILVD_EDD (E-value: 6.1e-217, bitscore:
                     710.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQLRSSFSTQGRRMAGARALWAANGMKKNQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQLVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVSDQEVANIEQNACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRTQLFKDAAELIVKNAKLYYEEGDESVLPRSIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAEVDFKMDDIDMLSRKAPCLCKVAPNTQKYHIQDVNRAGGIIAIMDELAKGG
                     LIDTSVRRVDGMSLAEAINEYSITSPNVSEKAIKKYSSAAGNKFNLVLGSQGMYYKELD
                     KDRANGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEA
                     ACEGILGGRVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPARKINVRLTDEELAARPMTPVTRDRY
                     VPKSLKAYASMVSSADKGAVRII"
     CDS             12852..13430
                     /locus_tag="ctg1004_9"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYTMEDGEKELFEEAKAEHPFQFISGLGTTL
                     EDFENQITALSKGDKFDFTIPADKAYGQYDEQHVIDLPKNIFEIDGKFDSERIKEGNIV
                     PLMTGDGQRVNASVVEIKPDVVVVDLNHPLAGADLIFEGEILESRPATNEEIQELVKMM
                     SGEGGCGCGCDSCGDGCGDDCGCEGGHCH"
     CDS             complement(13572..14537)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1004_10"
                     /sec_met_domain="SDH_alpha (E-value: 3e-63, bitscore:
                     203.3, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AEKRICISLKEDITEKLYIEVICKTEDKTAKAIIAGGHTTFIYIA
                     KNEQTLLDKQQTVSEEEEEASPELNLRKVYDFALTAPLDEIRFILDTARLNKAAAEQAF
                     KGNYGHSLGKMLRGTYEHKVMGDSVFSHILSYTSAACDARMAGAMIPVMSNSGSGNQGI
                     SATLPVVVFAEENGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGIT
                     WLMGGNYNQVAFAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAMMAMEDRCVTS
                     VEGIIDEDVDQSIRNLTRIGSQAMNETDKMVLDIMTHKGC"
ORIGIN
        1 gacacgtaca ttgaggaagc gtggttccat ggctgcatgt tcacggctgg aaccttctcc
       61 ataattctct tcggcaacaa caatagacgg aataccttca gacttataca tttttgccgt
      121 accggaaact gttccataag tatttgttga acgattccaa acgctgttcg tttcaccgtt
      181 gaaagcattg acagctccca tcagcatatt gtcggaaata ttctccaaat gtccccggaa
      241 gcggagccac ggacctgcca tagagatatg gtcggtagta catttgccct gtgctttaat
      301 cagtaaaggc atgttcagca agtcctgtcc gtcccacgcc gggaaaggcg tcaggagctg
      361 gagacgttga gaatcaggct tcaccttgat ttctgttttt gctccgtgtg gggcaatata
      421 tccctcattt ccctgttcaa aacctttcaa aggaagttca tctcctacag gctcggagag
      481 tttcactttt tctccgttat gattcaccaa tctgtctttc aacgggttga aacagagatc
      541 accggctatc gttaacgcca tcgttagttc cggagaagct acaaacgcat aggtgttggg
      601 attaccgtca gcacgtttgg caaaattacg gttaaaagag gtgacgattg agtttttccg
      661 tgtcggatcg tccgtctcac gtttccactg accgatacaa ggtccacaag catttgccat
      721 aatcgtggct cccagccgtt caaaagcctc aatcataccg tctctttcgg cagtagcccg
      781 gatttgctcc gaacccggat tgacgatcag cggagaagca acgctcaaat tcttttctgt
      841 cacctgcttt gccaaagaag ctgcacggct caaatcctga taagaagaat tggtacatga
      901 acctatcaag cccacctcca ttttacgggg atagccgttc aataacactt tttctgcaaa
      961 ttcagagata ggagtagcgg catccggtgt aaatggcccg tttatataag gttcgagttc
     1021 tgacaagtct atttcaatta cacggtcgta atagttggat ggttcgttgg tcacaatgtc
     1081 gtctgcacga aggtctgcac caacagattc agcccaatcg actacacaat ctcttccggt
     1141 agctctcaaa taagtagcca tgcgtccgtc aaaggggaac aaagaggtag tagctccaac
     1201 ttcggcaccc atattgcaaa tggtagcttt cccggtagca gaaagggatt cagttccggg
     1261 accaaaatat tcgataatag cattcgttcc tccttttacg gtaaggatgc cggccaattt
     1321 caggattaca tctttcggag aggtccaacc gcttagtttt ccggtcagac ggacaccgat
     1381 aatcttcggc attttcagct cccattccat tcctgtcatc acatccacgg catccgcacc
     1441 accaacaccg atagccacca tgcccagtcc gcctgcatta ggcgtatgag agtctgttcc
     1501 caccatcata ccgccgggga aagcatagtt ttcgagcacc acctgatgga taattcctgc
     1561 tcccggtttc cagaagccga tgccataacg ggaagataca tcacggagga agtcgtatac
     1621 ttcttcatta gtcagtcttg ccgtagcaat atccgccttt gcacctttat acgcctgtat
     1681 caaatgatcg caatgtactg tcgaaggcac agccacctga tccttacctg cattcataaa
     1741 ttgaagcaaa gccatctgcg cagttgcatc ctgcatagcc acacggtcgg gacggaaatt
     1801 cacataatcc tccccccgtt tgtaatcttt caaatcggct acatcataca gatgagcata
     1861 caaaattttc tcggccaacg tcaaagggcg tttcagtata gcccgtacgt gttctacctt
     1921 tcctttataa gcagcgtaga aagcttctaa catagtcaca tcatatacca tattgctttt
     1981 tgttttttta gtctatctat taaaataacg aacggcgttc gagtaatgtt taacaaaatg
     2041 aaatattttt tctacccgga acgaagattt gttacctttg cgcctattat gagtaataat
     2101 ccgaaaagtc ccattataga ccttcagcaa cagcaactcc tcctgcggat ggagtatgaa
     2161 tatgagaagg aagaatttaa gcggcagacc gaaacaatgg gcgttgcccg taaagtgaag
     2221 cgcggtctct gctggtatcc tgtctctctt ggccgaagtt actacaattc actgaatcag
     2281 cttgtaatag atattacacg gaccgaaaat aaagaaatag agcattcctt tgagttcggc
     2341 cgtcctgttt gctttttcca ccagtcattc gaaggaaaag tgaaatatat ggatttcatc
     2401 gctaccgtca gctttgccga cgaagaacga atggtcgttg tactccccgg agcgggagct
     2461 ttagcggaac tgcaaactga cggtatactg ggagtacaac tttattttga cgaaacatcg
     2521 taccgggcca tgttcgaggc actagaagac acgatacgcg ccaaagacaa ccgcctagcg
     2581 gaactgcgcg acattttgtt gggtacccaa aagccgggat tccgcgaatt atatcctgtc
     2641 cgcttcccat ggctgaacag tacacaggaa acagctgtta acaaggtgct ctgtacgcgt
     2701 gacgtatcta ttgttcacgg tcctccggga accggaaaga caacgactct tgtcgaagcg
     2761 atttacgaaa cgttacaccg ggaaccacaa gtgcttgtct gtgcgcaaag taacacggct
     2821 gtcgactgga tttgtgagaa actggtagac cgaggagtac ccgtgctccg cattggaaat
     2881 ccaacccgag tcaacgacaa aatgctttca tccacctacg aacgccggtt tgaaagtcat
     2941 cctgcttatc cggagctttg gggaatccgt aaatctatcc gcgaaatggg tagccggatg
     3001 cgccggggta gttcttctga acgggaagga atgcgtaatc gcatgagtcg tctccgcgac
     3061 cgtgccacgg agttggaaat acaaatcaat gccgatcttt tcgacagtgc ccgcgtgatt
     3121 gcttctaccc tagtcagcag caaccaccgc ctgctcaacg gacgtcgttt tccgacttta
     3181 ttcatcgacg aagctgcaca agccctcgaa gctgcctgct ggatcgctat ccgcaaagca
     3241 gaccgggtca tccttgcagg agatcattgt caacttccac cgactatcaa atgtatagaa
     3301 gcctcccgtg gaggattgga tcatacatta atggaaaaag tcgttcagca aaaaccttcc
     3361 gcggtctctc tattaaaagt acagtacaga atgcatgaaa ccatcatgca gtttccctcc
     3421 gactggttct atcatggaga actggaagct gctccggaag tacgctatcg ggggattctt
     3481 gatttcgaca ctcccatgaa ctggatcgat acttcagaga tggactttca cgaagatttt
     3541 gtaggcgaaa gcttcggacg catcaataag caggaagcca acctattact gcaagaactg
     3601 gaaacttaca tcgaacgtat cggcaaaaag cggatactgg atgaaagaat tgatttcggt
     3661 ctgatttcgc catacaaggc acaagtgcaa tatttgagag gaaaaataaa aggaagcagc
     3721 tttttacgtc ctttccgcag tctcatcacc gtgaatacgg tagacggctt tcagggacag
     3781 gagcgagacg ttattttcat cagtctcgta cgtgccaacg aggacggaca aatcgggttt
     3841 ctaaatgact tgcgaagaat gaatgtagcg attacgcggg cacgaatgaa acttgttata
     3901 ttaggagatg cctccaccct tgccaagcat cctttctata aaaggttgat gttattcatt
     3961 aaaaaggagg attaaatact taatcctcct tttaacaaag tgcactttct cacgaaaccg
     4021 cacttcattt aacacaaaca aaacaaacaa tattttacat cagtactatt cttaattttt
     4081 tcatcctcaa agatagtcga ttattccaat gcgctccaac tatttccacc attttatttg
     4141 cggatcgcgc gtttttgccc attctgcaaa tttaggatat gttttgtcaa tgcgctgatt
     4201 ctccttttta agatctaaat tcaaaataga agcgtccaaa cgagcatcta catgtatagc
     4261 aaacggaaaa ccatccttgc aaatgaaata ggtaccatct acatcaccac gagaaatatc
     4321 agctccggaa gggaaacgat tattcgcacc agtcgtcggc ttatgatctg tcagatgaac
     4381 ttctgtggca gagttgaata cttttataaa agggttatac ggagctacca ccactgcttt
     4441 atcaagagta gggttattaa attgtatgga taccgtatat gtcttctctt gaatattctg
     4501 attaatcata tcctccgcat tcacattgga tactcccaat tcagctttag catccttgaa
     4561 taatgttatc acattacctg aataggaaga agcttcacta ccattaaccg ttactttaga
     4621 agctttactc aaatcgaaag gaacttcata agcaaacgag ttcttataat tagctcccgt
     4681 ccaagccaag gtgaacttat caataatatt aagaacctta ttatctatat tataatcaac
     4741 gcttgactga tatttcatga ctacatcatt caagtcataa tctccttgtt ccggccagtt
     4801 atcttcaaag ccaagcactc cagaatacat ttctgttcct tgtcgatcac ccggattagg
     4861 aacatccgga acttcaatag cagcaatagg attagaagag ataacgaaag caacatcatt
     4921 atagtcattt tcaccgtttt tccagtcttc catagtgata acattcactc tatcacctgc
     4981 tttatttttt gctgcaaaaa ttgcagtgtg agaaattttg tcactattca aagatttggt
     5041 tgagtagaac atattcccat tagccttggc atttacccag ccattattcc atatcaagaa
     5101 accaatcttt gtatttgccg gaatacgttc cgggtccttt tgagggaaat taccagtctc
     5161 atttatatat tttaaattaa ctgcaacccc actataataa cctaaactat ttccatgtgc
     5221 gttaggaaat atgacacatg catgctttgt tgccttcctt atttcatcag tagaagcatc
     5281 tttcggatag caataataag caaatacact tttcgctcct gtgtctcccc caaaatagtt
     5341 aataacgaca tttgcatctt cttttatcag aatatcagca ttatcagtaa ctaaaggtcc
     5401 tacgttattc tttccttccg gaaaatatgt cgttatataa ctcttgagag ttgcatccac
     5461 gttgatcttc ttagaagcat ccaaatagtc aggcttacct gaatttgcat tccaagttcc
     5521 taatacgttc gggattacat ctgtaataaa tttcaccgca gcccttgttt gtgcacctct
     5581 cgttgatgaa tccacaggag taacatcaag agcattctca aaggttattt ttgcgctgac
     5641 atccgaaccg acaactttag ttttatacaa agtcggcaca ccaaaatccg gagaataaat
     5701 ataaacttct gaaactgctg tcgggaaaga agccggtttg atataacgtc cttgtatatc
     5761 tgtaaatccg gttgcaatgt gtgaaacccc tgctttcttt ataatctgac cgccttctgc
     5821 cacataagaa agcggatttt cagcataaac ttcaaaataa gccctaggac attcctttcc
     5881 ataatcaata ttcaattgaa tattcttagt agtagcaaag tcgaaatagt tatctaaagt
     5941 aacctcctct tctttatctc ctgaattagc aggatcatat acatctttct gcaaacagct
     6001 ggagaaagca acagaaacaa caccaataac acatactaat ttagtaatgt taatcattct
     6061 tttgggcaag ttaaaataca tcatacttct cgtttatttt atttgatggt gcaaatataa
     6121 acataaactt gcatatttta gtcatattat agatatattt ttctaaaaaa agcaatttaa
     6181 aggattcact cctcctttta tacaatgtat ttccaataaa aaaggagaaa gcaaaaagct
     6241 ctctccttct tttaaaactt gtataatctg gtctaattaa ttattctccg gacgaagttt
     6301 acgaacagtt acagcagtct gccacatttc gctttcgcgt aattgacgga gctcctcgtt
     6361 taacttttca cgataatcag gttgtgaatt actgtcgata gaaatctgcg cttcgttacc
     6421 agtcttcaca ctgttataca acttttcaac taccggtttg atagcatcgt ggaatgggcc
     6481 catccaatcg agagcaccac gttgagcagt agtagagcag ttagcgtaca tccagtccat
     6541 accgttcttt gcgaacaacg gcatcaatga ctgtgtcagt tcttccactg tttcattgaa
     6601 tgcttcagaa ggactatgac cgttttcacg caatacttcg tactgtgcca gcaacaaacc
     6661 ttggatagca cccatcaatg aaccacgttc acctgtcaag tcagaagtag cttcacgttg
     6721 gaaagttgtt tcgaacagat aaccggaacc gataccgata cctagtgcga tagttctttc
     6781 gtaagccttg cctgtagcat cctgatagat agcataagaa gagttcaagc cgcgtccttc
     6841 gaggaacata gtacgcaaag atgtacccga acctttagga gcaaccatga taacgtcgat
     6901 atcagcagga ggaactacac ctgtacggtc gttccaagtg atagcaaaac cgtgtgagaa
     6961 ataaagagct tttccggcag tcaggtaagg cttgatagta ggccatactg acattactgc
     7021 tgcgtcagac aacagacaca ttacaatagt acctctctca caagcttctt cgataccgaa
     7081 caaagtttca cccggaaccc atccgtctgc tactgcctta tcgtatgttt ttccttcacg
     7141 ttgaccaacg attacattga aaccgttatc acgcaagttc agtgcctgtc caggaccctg
     7201 tacgccataa ccgattacag cgattgtttc atttttcaat acttcacgag ctttttccaa
     7261 tggaaattcg tcacggatta ctacagtttc agtagtacct ccaaaattca actgtgccat
     7321 tttctttttg tttttagttt ttgatgactt acgccatccg ttattaattg attttatatt
     7381 ctcacattta ttcaaatatc actttcgagc ggcaaacaac ttcgttgcca ttcttcttca
     7441 cttctacgtg aaactcgttt gcattcactt catcgcagaa gaaagagagt tcatcaccaa
     7501 aatagctttc cgccacatac gccatttcaa aacgacggat acgtttggtc ttatacaatt
     7561 caatcgggaa caaatcaagg atatgttcga tgtaacggat gctgtttaca tgaccattga
     7621 tatctatatc actgtacttt gccgtcaggg tagctatcgg ctgatcgctt gtcactttga
     7681 tgcgtgaagg cttttcaatc gggcaaggct catcacagac atagtctacg atacttcccc
     7741 catgcaaagt caacaagtcg gcaggcttgc gggtattaag attaatcatt gcccatacgg
     7801 aacgtgcgta gccaatcttc tttccatcct tatcaataat agcaaaatta cggtccgtaa
     7861 acaaacggta gacattttcc acccaagtct gaaccgagaa attctcatac tgataaggca
     7921 tttcatccaa ctcaatagcc agacgtgaaa gcacccatgt ataattgtcc tcattcagcg
     7981 ttgcaatacc aaaaccacgg tcattggcgt gaaaacctgc acaattcagc agatgatttc
     8041 ccagtacccc catagtcaga cgtccgttga agtcaacatg gaacggttct gccacaaact
     8101 gataagtccc tattctattt tcttcactca ttattcttat tggtttttac tttggttata
     8161 catagcttcc cgtccatcga gaaactcatt cacccgttca aaacagctgg tagtaatcgc
     8221 tacacgtccc gaacgaacaa actgcaaaac acaattcaaa gccttcagtt caccatagag
     8281 cgaagttata tcttcgctca ttccattttt ctcgacaata gaaaataccg gattgacttc
     8341 cactatacgt gcattgtatc tacgaatcag cttggatgct tccggattct cctgaaaagc
     8401 aggagtagac accttatata atgcaatctc gtggaaataa atctcatcct ctgtgaaata
     8461 atgtgcctga atcacgtcga tcttcttttc gatctgtttc actaccttct caatgatgtc
     8521 cttatcagtc caggctgtta ttgtatactt atgtacacct ttaatagaag aagcagatac
     8581 attcagactc tcaatattta tttgccgacg ggtaaataca gcagttacct gattcagcaa
     8641 cccggctata ttctccgaat gaacaatgat tgtatataac gttttatcac tcataactct
     8701 aattttttaa atgcgaactc ttaactctcc attctcaact ctcaacttct cctagcactc
     8761 cagcaacatc tggtttaccg aaccacccgg aggagtcatc ggcaaaacat tgccttcttc
     8821 caccacgcaa gcttcgagca ggaacggacc gtccgttgcc agcatttcag caatagcttc
     8881 cttcagttct tcacgagtga aaacacgctt ggaaggaata tcataagccg aggccacttt
     8941 catataatcc ggattcaaca tcggggtaaa cgaatagcga cggttgaaaa acatagcttg
     9001 ccactgacgt acgtttccga ggtaattatt gttcaggcag ataatcttca ccggagcctt
     9061 ctgctccata atcgtaccca gttcctgaat attcatttgc agtccgccat ctcccataaa
     9121 tacgcatacg gtacgctccg gtgctccgaa agttgccccg atagctgcgg gaagcccgaa
     9181 gcccattgtt ccaagccctc cggaagtaat gatactgcgt tctttcgtat atttaaagta
     9241 gcgtgcagat atcatctgat tttgacctac atctgttacc aaaacagctt catggtgagt
     9301 agcgtcactt accgcacgta ccacttcccc catactcaac gagtttgtgg caggatgaag
     9361 ttcaggacgg attacttttt cctcctctac tttctcatat tctttgaagc tatcaatcca
     9421 ttcggtatga gtgttctttt tcaggagctt cgtcacagaa gccagtgttt ccttgcaatc
     9481 tcccaataca gctacatcta cctttacatt cttattaact tccgcaggat cgatatcaaa
     9541 atgaatcact tttgcctgtt tggcataagt agccaaatta ccggtcacac ggtcgtcaaa
     9601 acgcataccg acagcaatca gcacatcgca tttattggta ttgatattcg gtcccagatt
     9661 gccatgcata cccaacatac ctttattcaa cggatgttct gtcggcaaag ccgaaagtcc
     9721 gagcagcgta caacccgcag gcatatccgc tttttcgata aactcgcgca attcgctctg
     9781 tgcatttccc agttcaacac cttgtccaac caatacaagc ggacgttcag cgttattaat
     9841 cagttcggca gcagcctgta ctgtctcctc gtccgtatcg ggaacaggaa cataactacg
     9901 gataaaatcg actttcgtcg gttcgtattt cgttttctct acttgcgcat ttttggcaaa
     9961 gtccagtacc accggccccg gacgaccact acgagcaatg taaaatgcac gtgctaccgc
    10021 ccaggctaca tcttccgcac ggcgaatctg ataactccat ttagtgattg gctgggtaat
    10081 acctaccaag tcaacttcct gaaaagcatc cgtcccaaga aagcctgttc ctacctgtcc
    10141 ggcaatcacc acgataggcg tactatcgat catcgcatcc gcaatgcctg ttaccgtatt
    10201 ggttgctccg ggaccgctcg tcaccaggca aacacctaca tcacccgata cacgggcata
    10261 accctgtgcg gcatgggcag ctccctgttc gtgacgaacc aagatatggt tcaatatatt
    10321 ttgatgatcg tacaaggcat cgaataccgg cataatagaa ccaccggggt aaccaaagat
    10381 ggtagtcact ccctgatgtt ccaaggagcg catcaaagcc tctgcacctg ttattaaatc
    10441 tttcatatta gttgatagtt gataaatgat aaatgatagt tgagaaatga cagttgaaaa
    10501 tgaatggttt acaatcattg cgctaagtgc tgcgcagcta actattacct atcaactatc
    10561 accaactata ttatataatt ctcactgctc ccttatcggc agagcttacc atgctggcat
    10621 acgccttcag gctcttcggt acataacggt cacgagtgac aggagtcatc ggacgggccg
    10681 ccagttcttc atccgtcagt cgcacgttaa tcttccgggc cggaatatcg atttcgataa
    10741 tgtctccgtc tacaattttt ccgatattgc ctccagctgc cgcttcagga gaaatatgtc
    10801 cgatactcaa tccggaagtt ccaccgctga aacgtccgtc ggtaatcaaa gcacattctt
    10861 ttccgagatg acgggatttt atataagagg taggataaag catttcctgc ataccgggac
    10921 cacccttcgg accttcgtgc gtaatgacga cgacgtctcc actgacgact cgacctccga
    10981 ggataccttc acaggctgct tcttgcgaat caaatacttt ggcaggtccg gtaaacttcc
    11041 agatactttc gtctacacct gctgttttta ctacacaacc atcttgagca atattgcctt
    11101 tcaatacggc cagtccgccg tctttactgt aagcatgttc caagtcacgg atacatccgt
    11161 ttgcacggtc cttatccagt tccttatagt acataccttg tgaaccaagt acgagattaa
    11221 atttatttcc ggctgcgctc gaatatttct taattgcttt ttcgctcaca ttcgggctgg
    11281 tgattgaata ttcgttaatg gcttctgcca gtgacattcc gtctacccgg cgaacggatg
    11341 tatctatcaa acctcccttt gccagttcgt ccataatggc aatgatacca ccggcacggt
    11401 ttacatcttg aatatgatat ttctgtgtat tgggagccac cttgcagaga caaggagcct
    11461 tgcgggaaag catgtcaata tcatccatct tgaagtctac ctctgcttcg tgagcaacag
    11521 ccaacaagtg aagaaccgta ttggtagatc cccccattgc tatatccagc gtcatggcgt
    11581 tcaggaaagc ctgacgggta gcgatgctac ggggaagtac actttcgtct ccctcttcat
    11641 aatataattt tgcatttttc acgatcagtt ccgcagcgtc tttgaaaagt tgcgtacggt
    11701 tttcgtgtgt cgctacaatg gttccgttgc cgggaagagc cagtccgatt gcttcattca
    11761 ggcagttcat cgagttggcg gtaaacatac cggagcagca tccgcaagta ggacaagcat
    11821 tttgctcgat attcgctact tcctgatcgc taacactctc gtcggccgat ttaatcatcg
    11881 catcgatcaa atccaggtgc tggccattcc attctcccgc ttccatcgga ccacccgata
    11941 caaatacggc agggatattc agacgcatag ccgccatcaa cattccggga gtgatcttat
    12001 cgcaattact aatgcatacc attgcatccg ccttgtgcgc attaaccata tattctacgc
    12061 tgtctgcaat gatgtcacgt gaaggaagcg aataaagcat accgtcatgt cccattgcta
    12121 taccgtcgtc gatagctatt gtattgaatt ccgcagcgaa gcatcccagc ttctcaatct
    12181 ctgccttcac cagctgaccg atttcatgta ggtgtacatg ccccgggaca aactgtgtga
    12241 acgaattgac gatagcgata atgggtttac ccatctgatt cttcttcatg ccgttggctg
    12301 cccacaatgc acgggctccc gccatccgac ggccttgtgt actaaacgaa ctgcgtaatt
    12361 gctttttcat ttcaatctat cttttaatta aagagccttc ctcacacaag tgagaaaggc
    12421 tctaaattct atcttttatg gtacgaacac atacaacaca aaaacctttc tcacgctctt
    12481 gatgggacca ccacgacgcg aataatatgc aggactgcta ggttaataga tgtatgtaac
    12541 atattcatat cttcttttct ttattttcgt gctgcaaagg taagggcttt tttattatat
    12601 ccaaacaaat cgaagaaaaa aatcacttaa aagcgaataa ttgtaagaaa agagaggtat
    12661 tatttctcta ttttatcact taaaggttga atttacaact attatctaac tgcgcacctc
    12721 actttctttt tctgacaaaa gcacttaata atctgaaatt taccctccct ataccggagt
    12781 acaagcaaat aattcgtatc tttgtagatc cgtatttacg ggaattatta atcagaaaca
    12841 aaaaagatca gatggaaaca gtagaaaaca agtacattac cgttgcatac aaactatata
    12901 caatggaaga tggtgaaaaa gagttgttcg aagaagcaaa agcagaacat ccctttcaat
    12961 tcatttcagg attaggaaca acactcgaag atttcgaaaa tcagataact gctctttcta
    13021 aaggtgataa atttgatttt accattccgg cagataaggc ttacggacaa tatgacgaac
    13081 aacacgttat tgacctcccc aaaaatattt ttgaaataga tggcaagttt gatagcgaac
    13141 gtattaaaga aggtaacatc gtacctttga tgactggcga cggtcagcgc gtaaatgcca
    13201 gcgtagtaga aatcaaaccg gatgttgtag tagttgacct caatcacccg ttggctggtg
    13261 ccgacctgat tttcgaaggt gaaatactgg aaagccgtcc tgctactaac gaagaaatcc
    13321 aggaattggt gaaaatgatg agtggcgaag gtggttgcgg ttgcggatgc gacagctgcg
    13381 gtgatggctg tggcgacgac tgcggttgcg aaggcggaca ctgtcattaa ttgaagtatt
    13441 aagtataaag tattaagtat taattccgtg cggatataac cggagtttta atacttaata
    13501 ctttttttat gccgtcattc cggctaatac ttaatgccta atacttaata cttgatactt
    13561 aatacttaaa atcagcatcc tttgtgcgtc atgatgtcaa gtaccatttt atccgtttcg
    13621 ttcatggctt gcgagccgat tcttgtcagg ttacggatac tttggtctac atcttcatct
    13681 ataattcctt ctacggaagt cacacaacgg tcttccattg ccatcatggc agacagtacg
    13741 gctgtcgaaa ctccggtggt taccttcaag gcacaactcg gttttgcacc gtcacaaatc
    13801 attcctgtca aattggcaat catgttttga acagcgaaag caacctgatt gtagtttcct
    13861 cccattaacc aggtgattcc acaactggaa cctgtggcag ctaccacaca accacacaaa
    13921 gcagacaaac gtcccaaact ttgtttgata tatataacag tgagatggct aagcattaaa
    13981 gcacggatca gttcttcttc actttttccg ttttcttctg caaagacaac gacaggaagt
    14041 gtagcggata tcccctgatt accactgccg gaattactca ttacaggaat catagcaccg
    14101 gccatacggg cgtcacaggc agccgacgta taagagagga tatgagaaaa cacgctatcc
    14161 cccatcactt tatgctcata agttccccga agcattttcc ctaaagaatg tccgtagtta
    14221 cctttaaagg cttgctcggc agcagctttg ttcaaacggg ctgtgtcaag gatgaaacgg
    14281 atttcatcca gcggagcagt cagtgcaaag tcatatactt tacgcaagtt tagttcgggc
    14341 gaagcctctt cctcttcctc gctgactgtc tgttgcttgt cgagcaacgt ttgttcattt
    14401 ttggctatat atataaaggt agtatgtcca ccggcaatga tggctttagc cgttttatct
    14461 tccgttttac aaatcacttc gatataaagc ttttccgtaa tatcttcttt cagagaaata
    14521 caaatccgtt tttctgc
//
