LOCUS       c00357_gnlPro..         4976 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KLCMFMLH_357.
ACCESSION   c00357_gnlPro..
VERSION     c00357_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 11:29:15
            Original ID  :: gnl|Prokka|KLCMFMLH_357
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4976
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..4976
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[165:4332]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      166..4332
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..4976
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..4976
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             166..1968
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg357_1"
                     /sec_met_domain="ILVD_EDD (E-value: 5.2e-218, bitscore:
                     712.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFT
                     QFVPGHTHLHEIGQQVKVEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNNQHLDLID
                     AMIKSADASVSDEDVAQIENNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATH
                     ANRTQLFKDAAALIVKNAYKYYEEGDDSVLPRNIATRDAFLNAMTLDIAMGGSTNTVLH
                     LLAIAHEAEVDFKMDDIDMLSRHVPCLCKVAPNTQKYHIQDVNRAGGILNILGELSKGG
                     LLKTDVKRVDGLTLAEAVEKYNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELD
                     TDRANGCIRDLQHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPNRSINVKLSDEELAARPMTAVTRDRK
                     VPKSLKAYASMVSSADKGGVRIID"
     CDS             2070..3767
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg357_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-50, bitscore:
                     158.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHRNT
                     LNHILVRHEQGAAHAAQGFARVSGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPVVLD
                     FAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGN
                     AQDELRAFIEKADMPCGCTLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVG
                     MRFDDRVTGKLDTYAKQAKVIHLDIDHSEIDKNVKVDVPVLGNCKYTLAMLTQLIRKNE
                     HSEWIDSFTEYEKTEYEHVISKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQM
                     MAARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMERKAPVKIILLNNNYLGNVRQWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVM
                     KREELQAAIHEMLTTDGPFLLEACVIEEGNVLPMTPPGGSVNQMLLEC"
     CDS             3778..4332
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg357_3"
                     /sec_met_domain="ALS_ss_C (E-value: 4.9e-20, bitscore:
                     59.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENIAGLLNQITAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTTRDVIEKVVKQIEKKIDVLQAHYFTDSEIYQHEIALYKVSTPEFQENPM
                     ASKVIRRYSARIVEVNPVFSIVEKNGMSEEITALYEELRGLGCVLQFVRSGRVAITTSC
                     FERVNEYLTQREEKYRQQKTE"
     CDS             4332..4976
                     /locus_tag="ctg357_4"
                     /transl_table=11
                     /translation="MMSENKVGTYRFVAEPFHCDFSGKLTMSVLGNHLLNCAGFHAADR
                     GFGIATLNENHYTWVLSRLAVELENMPCQYEGFSIQTWVENVYRLFTDRNFAILDKEGK
                     TVGYARSVWAMISMETRKPADLLTLHGGSIIDYVCDKKCPISKPGRIKVTEKAPVSEYQ
                     TRYSDIDINGHVNSIKYIEHILDLFPIEFFKEKRIKRFEMAYVAESYYGDIL"
ORIGIN
        1 taacctagca gtcctgcata ttgttcgcgt cgtggtggtc acactaggag cgtgagaaag
       61 gttgtgtatg tgtagttgta catataaaga aataattgga agcctttctc acatggtgag
      121 gaaggctttt tcaataagta taggacgtta tagatttaga ataagatgaa gaatcagtta
      181 cgcagttcgt ttagcacaca gggtcgccgt atggcaggag cgagagcttt atgggtggct
      241 aacggcatga aaaaagaaat gatgggcaag cccattatag ccatagtaaa ttcgtttaca
      301 cagtttgttc cgggacatac ccatctgcat gaaataggtc agcaggtgaa agttgagatt
      361 gaaaaattgg gatgttttgc agcagaattc aatacgattg ccattgatga cggaatagct
      421 atgggacacg atggtatgct gtattcactg cccagtcgtg atatcattgc cgacagcgtg
      481 gaatatatgg tgaatgctca caaggcggat gcaatggtgt gtatcagtaa ttgtgacaaa
      541 atcactccag gtatgctgat ggctgccatg cgactgaaca taccggctgt ttttgtatcg
      601 ggtggtccta tggaagcggg agaatggaat aaccagcatc ttgatttgat agacgccatg
      661 attaaatctg ctgatgcatc ggtcagcgat gaggatgtgg ctcaaattga aaataatgcg
      721 tgtcctggct gtggttgctg ttcgggtatg tttacggcta attccatgaa ttgcctcaat
      781 gaggctattg gtctggggct tccggggaat ggcactattt tggcgactca tgccaaccgt
      841 actcagttgt ttaaagatgc ggctgctctg atagtgaaga atgcttataa atattatgag
      901 gagggagatg acagcgtgtt accacgcaac attgctactc gtgacgcttt tctgaatgcc
      961 atgacattgg atattgcaat gggtggttct accaatactg tgctccatct tttagctatc
     1021 gcccacgagg cggaagtaga tttcaagatg gatgatattg atatgctttc acgccatgtg
     1081 ccttgtttgt gtaaagtagc tccgaataca cagaaatatc atattcagga tgtgaaccgt
     1141 gccggtggta tccttaatat attgggagaa ttatccaagg gtggtttgct gaaaactgat
     1201 gtgaaacgag tggacggcct gacattggcg gaagctgtcg aaaaatataa tatatgtaag
     1261 aaagaagtgg atactgaagc aaaacgtatt tattcaagtg ctccgggaaa caaattcaat
     1321 ataaagttag gttctcagaa tgctgtttat aaagaactgg atacagatcg tgccaatggt
     1381 tgtatccgcg atttgcaaca tgcctatagt aaagatgggg gtttggccgt tttgaaaggg
     1441 aacattgcac aggatggttg cgtagtgaaa acggccggag tggatgaaag tatttggaaa
     1501 ttctcggggc ctgccaaggt gtttgattcg caggatgctg cttgtgaagg tattttagga
     1561 ggaaaagtag tcagcggaga tgttgttgtt atcactcatg aaggtccgaa aggtggtccc
     1621 ggtatgcagg aaatgcttta tcctacttcc tatatcaaat ccaagcattt aggaaaagaa
     1681 tgtgctttga ttaccgacgg acgttttagt ggaggaactt cgggattaag catcgggcat
     1741 atttctcccg aagctgcagc gggtggtaat atcggaaaaa tagtggatgg tgatataatt
     1801 gaaatcgata ttccgaatcg cagtatcaat gtgaaactga gtgacgaaga attggccgcc
     1861 cgaccgatga cagcggtgac ccgtgaccgt aaagttccta aaagcttgaa ggcatacgct
     1921 agtatggtaa gttctgcaga taaaggagga gtgagaatca ttgactaaat tagaaattaa
     1981 aaattgagaa taaaaaaaat agatttgttg tcattggtcg attgtccggc atcgtatttt
     2041 tttgattctc aattctcaac taaacaatta tggcaaaaga aaagataaca ggagcagagg
     2101 cgatgatgcg ttctttggag tatcaaggag tgaaaactct tttcggatat cccggaggtt
     2161 ctatcatgcc tacttttgat gctttatatc atcatagaaa tacattgaac catatattgg
     2221 tccgtcatga acaaggagct gcccatgcag cacagggatt tgcccgcgta tccggtgagg
     2281 ttggtgtctg tttggtgact agcgggcccg gtgcgacaaa taccattact ggcattgccg
     2341 atgctatgat tgacagcacg cctatcgtgg tgattgccgg gcaggtagga gcttcctttt
     2401 taggtacgga tgcttttcag gaagtggatc tggtgggcat cactcagcct attaccaaat
     2461 ggagttacca aattcgtcgt gcggaagatg tagcttgggc tgtagcccgt gctttctata
     2521 tagctaaaag cggacgtccc ggtcctgtcg ttttggactt tgccaagaat gcacaagtgg
     2581 agatggtgga ttatgaaccg atgaagcttg attttatccg tagttatgat ccagaaccta
     2641 atcctgataa ggaatctctt caggaggctg ccgaattgat aaacaatgct caaaggccat
     2701 tagtgttggt aggacagggg gtagagttag gtaatgcgca agatgagtta cgtgcattta
     2761 tagaaaaagc cgatatgcct tgtggctgta ctttgctggg actttcggct ataccaactt
     2821 cgcatccttt aaacaaagga atgttaggta tgcatggaaa tctggggccc aatgtcaaaa
     2881 ctaatgaatg tgatgtgttg attgctgtag gtatgcgctt tgacgatcgt gtaactggaa
     2941 aattagatac atatgctaaa caggcaaagg tgattcattt ggatattgac cattctgaaa
     3001 tagataagaa tgtaaaagtg gatgtacccg tattaggtaa ttgtaaatat acgctagcta
     3061 tgctgacgca acttatccgg aagaatgaac attccgaatg gattgatagc tttactgaat
     3121 atgaaaagac ggaatatgaa catgttatca gtaaagaaat tcatcctgtt gacggggcgt
     3181 tgaatatggg tgaagtggtg cgtgcggtaa gtgaggcttc gaacaacgag gctgtattgg
     3241 tgacagatgt aggacagaac caaatgatgg ctgctcgtta ttttaaatac agtaagaacc
     3301 gtagcattgt aacttcgggt ggattgggaa cgatgggatt cggtcttccc gctgctatag
     3361 gcgctacttt cggtcgcccg gatcgtactg tatgcgtatt tatgggggat ggcggtttgc
     3421 agatgaatat tcaagaattg ggaactatca tggagcgaaa agcaccggta aagattattt
     3481 tattgaacaa taactatttg ggtaatgttc gtcaatggca agctatgttt tttggtcatc
     3541 gttattcatt tactccgatg ttgaatccgg attatatgaa gattgccgag gcatatgaga
     3601 ttcctgcccg ccgtgttatg aagcgtgagg aattgcaggc tgctatccat gaaatgttga
     3661 ctactgacgg gccattcctg ctggaagctt gtgtgataga agagggaaat gtgttgccga
     3721 tgacacctcc gggaggctcg gtgaatcaga tgttactgga atgctaattt aataattatg
     3781 gacaagacat tatatacatt aatcgttcat tcagaaaata tcgccggttt gctgaaccag
     3841 attacggcag tgtttactcg ccgccaaatt aatatcgaaa gtcttaatgt ttctgcatct
     3901 tccatcaagg gggtgcataa atatactatt actgcttgga ccacccggga tgtgatagaa
     3961 aaagtggtga agcagattga aaagaaaata gatgttttgc aggcacatta ttttactgat
     4021 agtgagattt atcagcatga gattgctttg tacaaggttt ctactcctga atttcaggag
     4081 aatcctatgg catctaaagt tatccgccgt tatagtgccc gcattgtaga agtgaatccg
     4141 gttttctcta ttgttgaaaa gaatgggatg agtgaggaaa ttactgctct ttatgaggag
     4201 ttgcgcggat tgggatgtgt gttgcagttt gtccgttcgg gacgtgtggc cattactacc
     4261 agctgtttcg agcgtgtgaa cgaatatctg acccaacgcg aggaaaagta tcgccagcaa
     4321 aaaacagaat aatgatgagt gagaataaag taggaacata cagatttgtg gcagaaccct
     4381 ttcactgtga tttcagtgga aagttgacca tgagtgtgtt gggtaatcat ttactgaatt
     4441 gtgccggctt tcatgctgcc gaccggggtt tcggaattgc tacgctcaat gagaatcatt
     4501 atacatgggt actttcccgt ttagctgtag agttagagaa tatgccctgt caatatgagg
     4561 gtttcagtat tcagacatgg gtagagaatg tttatcgtct ttttacagac cgtaattttg
     4621 caattttgga caaggaagga aagactgtcg gatacgcccg ttctgtatgg gcgatgatca
     4681 gtatggaaac tcgcaaacct gctgacctgc ttacgcttca cggaggtagt atcattgatt
     4741 atgtatgcga taagaaatgt cctataagca agcccggtcg tattaaggtg acagagaaag
     4801 ctccggtttc tgaataccag accagatata gcgatattga tattaatggt catgtgaaca
     4861 gtattaagta tatagaacat attctcgatt tgtttcctat agagtttttt aaagagaaac
     4921 ggattaaacg ttttgagatg gcttatgtag ctgagagtta ttatggtgat atattg
//
