LOCUS       c00500_gnlPro..        15527 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ODKNMFEK_500.
ACCESSION   c00500_gnlPro..
VERSION     c00500_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 14:46:20
            Original ID  :: gnl|Prokka|ODKNMFEK_500
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15527
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15527
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[7860:12504]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      7861..12504
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15527
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15527
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(3..368)
                     /locus_tag="ctg500_1"
                     /transl_table=11
                     /translation="MSYIQNNLQAGEEIKYKADIHWYIFAYPVILLLLSVFFSSAQTGF
                     FHYVSLFLLLSGLFQLIKRILLKMGTEYVVTNKKVILKSGILSRDALELVLNKCEGIRI
                     NQSLMGRMLGFGSIVVTT"
     CDS             complement(527..970)
                     /locus_tag="ctg500_2"
                     /transl_table=11
                     /translation="MKKIITLLLILLFTTKSTFSQSPNNIEKFTVVCVNDKDSILNKIK
                     MSTPQFYNIGKGKRIEIKVCNEDSIQIRRVRCLLYYSNSGKKECIGKIWISPLIGYETC
                     YFCMNVDIPLTKDEWHKLTFRIKRGKNYKDYKFLKQQVQEENI"
     CDS             1341..1523
                     /locus_tag="ctg500_3"
                     /transl_table=11
                     /translation="MDILVWGGLGNSDYLEKMMSFSNIYLYFWLKRKQGISRVYIWCFF
                     ICILNGLRFYDKHYR"
     CDS             1504..2067
                     /locus_tag="ctg500_4"
                     /transl_table=11
                     /translation="MTNIIDNMLSLCPVSEDTIQELKKCMILCRFPKKYQLIKENTFCK
                     SAYFIEKGMTRSFWLVNGEEITTSFSWEGGIVFSMDELYYNKPSEEFVETLEDVVVYKI
                     SLVDLTKLFQTNIELANWGRIIHQNEYRRLHRSHKERLTLPAKERYEEFKQQFPQICQR
                     VKLRYIASYLGITLPTLSRLRAKK"
     CDS             2185..3336
                     /locus_tag="ctg500_5"
                     /transl_table=11
                     /translation="MEKISSAAFTDTKPHYDLLDGLRGVAALMVIWYHVFEGFAFASAG
                     NIETLNHGYLAVDFFFILSGFVIGYAYDDRWGKNFTMKDFFKRRLIRLHPMVIMGAVLG
                     AITFCIQGCVQWDGTHVAISMIMLSLLCTIFFIPAMPGVGYEVRGNGEMFPLNGPCWSL
                     FFEYIGNILYALFIRRLSNKALAVLVVLLGMALASFAVFNVSGYGNMGVGWTLDGVNFL
                     GGTLRMLFPFSLGMLMSRNFKPMKVNGAFWICTIILIALFSVPYLEGLEPICMNGIYEA
                     FCVIAVFPFLVWLGASGTTTDKQSTKICKFLGDISYPVYVVHYPLMYLFYAWLIENKLY
                     TLGETWYVAVGVFVLSVILACLCLKLYDEPVRKWLSKKFLAPK"
     CDS             complement(3510..3935)
                     /locus_tag="ctg500_6"
                     /transl_table=11
                     /translation="MNETIYLKKLEQREIKPTAIRLLILKTMMQHKEAFSLLDLENELD
                     TVDKSTIYRTITLFLAHHLVHGIDDGTGSLKYAVCSNDCNCEVDDLHTHFYCENCHRTF
                     CMKSIHVPIVTLPPGFTVQSINYVLKGLCSECSHQHV"
     CDS             complement(3958..5667)
                     /locus_tag="ctg500_7"
                     /transl_table=11
                     /translation="MKKIKLESVFNEFTLMGIAVSGAFYLGEYWEGIAVILFYLIGEWF
                     QHKAVHKARSNIKALLDVRPETATVVYNNTYKITAPEKVQPGETIEVKVGEKVSLDGFL
                     LEDSASFNTATLTGESVPRTLYKQEEVLAGMIASDKVVRIKVNKPYDQSTLARILTLVQ
                     DAAERKAPAELFIRRFARIYTPIVTGLAILVVILPYLYSLIKPEFIFVFDDWFYRALVF
                     LVISCPCALVVSIPLGYFGGIGAASHKGILFKGGNYLDAITQINTVVFDKTGTLTQGVF
                     SVQAISAAEGVSQKELLQLIASIESFSNHPIAKAIVKYAEEQSISLNSSLRITEFAGYG
                     IKAVTNGKEVYVGNTRLLSKYGISFPYEISNMTETIVLCAMENKYLGYLSLADTPKPDA
                     VQAIRELKDLNINNIQILSGDKQTIVSNLAEKIGVTHAFGDLLPEGKVAHLEQLKANFE
                     NRVAFVGDGINDTPVLALSDVGIAMGGLGCDAAIETADVVIQTDQPSKVAEAIKIGKQT
                     HRIVWQNISMAFGVKLLVLLLGAGGMATMWEAIFADVGVALLAIFNAMRIQK"
     CDS             5765..6583
                     /locus_tag="ctg500_8"
                     /transl_table=11
                     /translation="MKKRYWAFLIGSWCLSVGMQAAKVDTLSVHSDAMNKEVQVITICP
                     DKAMAGEKCPVLYLLHGYGGNAGTWLGIKPELPQIADKEGIIFVCPDGKNSWYWDSPLN
                     KEYRYETFVSKELVNYIDKNFTTKVERGGRAITGLSMGGHGSLWLSIRHKDVFGGGGSM
                     SGGLDIRPFPNNWEMKKQLGEEASNKQRWDEHTVINQLDKIKNGDLAVIIDCGCDDFFL
                     EVNKVVHEKLLKKKINHDFIIRPGGHTGRYWNNAIDYQILFFSKFFNKSK"
     CDS             6588..7346
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg500_9"
                     /sec_met_domain="adh_short (E-value: 1.6e-56, bitscore:
                     181.3, seeds: 44, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKIVFITGASSGIGAGCARKFASQGASLILNARNVNKLSALKEE
                     LEKQYGTEIYLLPFDVRDRKAATSALESLPKEWQSIDILVNNAGLVIGTDKEQEGSLDE
                     WDIVIDTNVKALLAMTRLIVPGMVERKRGHIINIGSIAGDAAYPGGSVYCATKAAVKAL
                     SDGLRIDLVDTPLRVTNIKPGLVETNFSVIRFRGDKEKADNVYKGIRPLTGDDIAETVY
                     FAASVPEYMQIAEMLVMPTYQATGTIVSRK"
     CDS             complement(7438..7686)
                     /locus_tag="ctg500_10"
                     /transl_table=11
                     /translation="MEKKTVKYHIPQHGIYMYARTNSGKTELIVLNSTNAEQVVANNHY
                     RIMTNDSKSGKELISGKKIDLTKNMTVGARQSLIIEL"
     CDS             complement(7861..9021)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg500_11"
                     /sec_met_domain="OAD_beta (E-value: 3e-153, bitscore:
                     500.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFINFLGNNLADFWTYTGFANATVGHIVMILIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALAMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGLTVGAS
                     TQASEFLTIDSILIFALGALSFIIATASGVIFVKIFNLVLGKDNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(9023..9454)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.7; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg500_12"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.7e-21, bitscore:
                     64.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNIYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAV
                     VKPVVRPASTSPAPAPTTVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE"
     CDS             complement(9478..10407)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg500_13"
                     /sec_met_domain="OAD_gamma (E-value: 2.3e-15, bitscore:
                     47.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNIGIFLSLLLMVGLCSCGEQKSNTKLVLNEVLIENESNFQD
                     DYGVHSAWIEIFNRSFGSADLAGCLLKVSSQPGDTATYFIPKGDVLTLIKPRQHALFWA
                     DGEPNRGTFHTNFTLNAATNNWIGLYDSGKKLLDQIIVPAGTLQANQSYARVSDAANEW
                     EVKGSSADKYVTPSTNNKTINSNAKMEKFEEHDSVGIGMSISAMSVVFVGLLLLFIAFK
                     VIGRISVNLSKRNAMKVKGITDKQEAKEKKLGEAPGEVFAAIAMAMHEMQSDVHDVEET
                     VLTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(10435..11988)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg500_14"
                     /sec_met_domain="CT_Btheta (E-value: 8.5e-292, bitscore:
                     958.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRATARMGGGDKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLAMIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPN
                     KPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(12091..12504)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg500_15"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.1e-25, bitscore:
                     80.5, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVKTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVANALAEAETTGIRL
                     IDKAPRKGAEGLQIAFLHPKSTLGVLTELCEKP"
     CDS             complement(12661..13683)
                     /locus_tag="ctg500_16"
                     /transl_table=11
                     /translation="MWIDKQKTINLQLEMPVRLSTYRKGNAIPPLPGTNIFHSTELFHV
                     FEMTRGYEPLLIVAYIGNRPVGKLLAVIRKSMRLFPPAIIKRCEIYGTGEYFDEEQNKE
                     DLFGEMLEHLTNEVLCKSFLIEFRNLENPLFGYKAFRKNNYFAINWLRVRNSLHSKVPY
                     ERLSMSRKRQINKALRNGAIMEVADNEKDIQDFSRMLKKAYSSQVRKHFPDIGFFRLLA
                     WQNPEKELAKVFLVKYKGKIIGGSICLFSKESAYLWFSGGMRKTYAFLYPGILAVWAPI
                     TYAHEKGYAHLEFMDAGLPFKKHGYRDFILRFGGKQSSTRRWFRFSWKWLNKLLCKFYI
                     "
     CDS             13729..14265
                     /locus_tag="ctg500_17"
                     /transl_table=11
                     /translation="MEQFSDLIKNRRSMRKFTDQELTQEEVVALLKAALMAPSSKRSNC
                     WQFLVVDDKYMLEKLSHCKEMGAAFLADAAMAVVVMADPLASDVWIEDAAIASIMIQLQ
                     AEDLGLGSCWIQVRERFTATGMPSGEYVHTLLDIPLQLQVVSIIAVGHKGMERKPFNED
                     HLQWEKIHINKFGGK"
     CDS             14268..14594
                     /locus_tag="ctg500_18"
                     /transl_table=11
                     /translation="VAAVNHKDTYKASAVFLIVMGMLYLIDKFIGFASHGLPWVMQKDN
                     LLLYAAVIFLWFKADKSVGIVLAGIWLILNISLVIALLGQMSAYLLPAALLLLGVILYL
                     VSTR"
     CDS             14594..15400
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg500_19"
                     /sec_met_domain="F420_oxidored (E-value: 2.6e-10, bitscore:
                     31.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVLIGAGNVATHLGIALQKAGCLILQVYSRTEESASALADRLL
                     VDYTIVPDEIRRDADLYIVALKDAVLRQLAPVLVKGREQALFVHTAGSMPMDLWKGLVK
                     RYGVLYPMQTFSKQREVDFNTVPFFIEASAPAEVGVLRMVAVRLSPKVYEVTSGQRRHL
                     HLAAVFACNFANHMYALSSHILEKQGISFEVMLPLIDETAGKVHELSPTQAQTGPAVRY
                     DENVISKHLEMLADEESLQELYEKISKSIHDLPLSVIQTNKEGKNS"
     CDS             15406..15525
                     /locus_tag="ctg500_20"
                     /transl_table=11
                     /translation="MINYDLKKIKALVFDVDGVLSAETIYLHPNGEPMRTVNIK"
ORIGIN
        1 cctgtagtaa ctacaataga accaaaaccg agcatacgtc ccatgaggct ttgattaatc
       61 cgtatccctt cgcatttgtt taaaaccaat tcaagggcat cccggcttaa aataccggat
      121 tttagaatga ctttcttgtt tgtgacaaca tattcagtgc ccatcttaag aagaattctt
      181 tttatcaatt ggaataatcc ggacaataat agaaataagc taacataatg gaaaaatccg
      241 gtttgtgcag aagaaaagaa aacgcttaat aatagtagta ttaccggata tgcaaatata
      301 taccagtgaa tatctgcttt gtattttatt tcttcaccag cttgtagatt gttttggata
      361 tagctcattg tttttgtaaa ttaatagatt gcataatttt attatcaaaa gacaaatata
      421 aggataatca gaatggtata aaataaatct tggtttattt taaagctgaa acttaaaata
      481 aaaacaattc ttcctgtttt tcttcttgtc aatatctctt ttcttatcaa atattttctt
      541 cttgtacttg ttgtttcaag aatttgtaat ccttataatt ttttcctctc tttattcgga
      601 aagttagttt atgccattcg tcttttgtta gggggatatc cacgttcata caaaaatagc
      661 aggtttcgta gccaatgaga ggggaaatcc atatttttcc tatacattct ttcttgccgg
      721 agttggaata atataaaaga cagcgtactc ttcttatttg tatgctgtct tcattgcata
      781 cttttatctc tatacgttta ccttttccga tgttgtagaa ttggggagta gacattttta
      841 ttttgtttaa aatactatct ttatcattta cacagactac ggtgaacttc tctatattgt
      901 ttggtgattg ggagaaagtg ctttttgtgg taaacaacaa tattaaaagt aatgttataa
      961 tttttttcat gtgattggac ttgttggtta aagcagtagc agattattaa ttaagatttt
     1021 actcttctga taatagatac ttcatactgc aaagtaaata ttttttttgt tttaagggtt
     1081 ataattgtta aaatgcaaaa atagcctgca tctgccaatc tgtcaagggc tgtttttcat
     1141 aaaaaatgtt caattctttg gtatttcttt tggattttct tggtatgaaa tttctgatag
     1201 attatatgaa aagtgatttg aaggctattg caattctttt agagtggtgc attaagcaat
     1261 gggaagtttt aaaagcttga ttggcatttg aatgctttat ctttgtaatt tgaacaaaaa
     1321 gtaataaata aaagaggtat atggacattc ttgtatgggg tggtcttgga aattccgatt
     1381 atttggaaaa aatgatgtcg ttttccaata tatatttgta cttttggctg aaaagaaaac
     1441 aaggtatatc ccgtgtttat atttggtgtt tttttatatg tattttaaat ggactgaggt
     1501 tttatgacaa acattataga taatatgctc tctttgtgtc cggtttctga agatacgata
     1561 caagaactga aaaaatgtat gattttatgt cgtttcccta agaaatatca gttaataaag
     1621 gagaatacat tttgtaaatc agcttatttc atagaaaaag gaatgacgcg ttctttctgg
     1681 cttgtaaatg gagaagaaat aacaacctcc ttttcatggg aaggaggtat tgttttcagt
     1741 atggacgagt tgtactataa taagccgagc gaggaatttg tggaaacgct tgaagatgta
     1801 gttgtttaca aaatatcatt agttgattta accaagctgt ttcagactaa tattgaattg
     1861 gctaattggg ggaggattat tcatcaaaat gagtacaggc gtttgcatcg ttctcacaaa
     1921 gaacggctga ctttgcctgc aaaagaaaga tatgaggagt ttaaacaaca gtttcctcaa
     1981 atatgccaac gggtgaagtt aaggtatatt gcatcttatt tgggtataac acttcccaca
     2041 cttagtcgtc ttcgagctaa aaaataattt atgtattact gtttttttgt cataggacaa
     2101 atttaaaagc ctttaagttg tgtaactttg cagcattatt agtaacggtt aaaaagaatt
     2161 aattattaaa tctattaatt tattatggaa aaaatctctt ctgcagcatt tacagataca
     2221 aagcctcatt atgatcttct tgatggattg agaggagtcg ctgctcttat ggtaatatgg
     2281 tatcatgtat ttgaaggctt tgcttttgct agtgccggta atatcgagac tctcaaccac
     2341 gggtatcttg ctgtggattt cttttttatt ctttcgggtt ttgttatcgg ttatgcgtat
     2401 gatgaccgtt gggggaagaa tttcactatg aaagactttt tcaaacgccg tttgatccgt
     2461 cttcatccga tggtaattat gggtgctgtt ttgggagcta ttacgttctg tattcaaggt
     2521 tgtgtgcaat gggatggaac gcatgtcgcc atttccatga ttatgttgtc tttgctttgt
     2581 acaatattct ttattcctgc catgccgggt gtgggatatg aagttcgtgg taatggtgag
     2641 atgtttccat tgaacggacc ttgctggtcc ctgttttttg agtatatagg taatattctt
     2701 tatgcgttgt tcattcgtcg tttgtctaat aaagcattgg ctgtgctggt tgtgttgctg
     2761 ggtatggcat tagcgtcatt tgctgttttc aatgtgtctg gttatgggaa tatgggagtg
     2821 ggatggacac tcgacggagt gaatttctta ggtggaacct tacgtatgct tttcccattc
     2881 tcgttgggta tgttgatgtc gcgtaacttt aagcctatga aggtgaatgg ggcattttgg
     2941 atatgtacta ttatactgat tgcgctgttc tcggttcctt atctggaagg attggagccg
     3001 atttgcatga atggtattta tgaagctttt tgtgtaattg cggtttttcc ttttcttgtg
     3061 tggctggggg cgtcgggtac tactacggat aagcagtcta caaagatatg caagttcttg
     3121 ggagatatat cctatccggt ttatgtagta cattatccgt tgatgtattt gttctacgca
     3181 tggttgattg agaataaact ttatacattg ggagaaactt ggtatgtagc tgtgggtgtt
     3241 tttgttttga gtgtcatttt ggcttgcctg tgtctgaaac tgtatgatga gcccgtaaga
     3301 aaatggctga gtaagaagtt tcttgctccc aaataaaaat actgcatttc ttgatggatg
     3361 ttcattaaaa ggtcggacac tatacaagaa gatattacag ctttgaataa ctgacaatta
     3421 gatgaatggc atccgatctg taaattcgga tgcctgcatt cgattatttc aaaatgggct
     3481 ttaggattga tttccttttt tggcaatagt cacacatgtt gatgagagca ttccgagcat
     3541 agacctttca ggacataatt gatactttgt acggtgaatc cgggaggtag tgtcacgatg
     3601 ggcacgtgga tacttttcat acaaaacgtg cgatgacagt tctcacaata aaagtgagtg
     3661 tggagatcgt ctacctcaca attgcaatca ttgctgcaca cggcatattt taacgatcct
     3721 gtgccgtcat caatgccatg aaccaaatga tgggctaaaa aaagggttat ggtgcggtag
     3781 atggttgatt tgtctaccgt atccaattcg ttttccaaat ccaacagtga aaatgcttct
     3841 ttgtgctgca tcatggtttt tagaataagc agacgtatgg ctgtcggttt gatttcccgc
     3901 tgttccaatt tttttaaata gattgtttca ttcataggtc aaatcatttt attcttttca
     3961 tttctgtatt ctcattgcat taaaaatggc gagtaaagct acgcctacat ctgcaaatat
     4021 agcttcccac atagtggcca ttccgccggc tcctaatagc aatactaaca atttcactcc
     4081 gaatgccatc gatatatttt gccatacaat gcgatgggtc tgttttccta tttttatagc
     4141 ttccgctact ttactgggtt ggtctgtttg tatcactaca tccgcagtct ctatagcagc
     4201 gtcacagcct agaccaccca tggcaatccc aacatcgctg agtgccagta cgggagtatc
     4261 attgataccg tctcctacaa aagctacacg attttcaaaa tttgctttta attgttctaa
     4321 atgtgctact ttaccttcgg gtagtaaatc gccgaaagca tgtgtgacac ctatcttttc
     4381 ggctaaatta gaaacaattg tctgtttatc tcccgataat atttgaatat tattaatatt
     4441 taagtctttc agctcgcgga tggcttgtac agcatcaggt tttggggtat ccgccaatga
     4501 aagatatccc aaatatttgt tttccattgc acatagcacg attgtttctg tcatgttgct
     4561 gatttcatag ggaaaagaga tgccgtattt tgataataac cgtgtatttc ctacatatac
     4621 ttctttaccg tttgttacgg cttttattcc atatccggca aattcagtga ttctcagtga
     4681 cgagttaaga gatatacttt gttcttccgc atatttgaca atggcttttg cgataggatg
     4741 attgctgaaa ctctctatag aggcgataag ttgaagcagt tccttttgcg aaacaccttc
     4801 ggctgccgat attgcctgaa cactgaatac accttgggtg agtgttccgg ttttatcgaa
     4861 tactacggtg tttatttggg ttatggcatc tagataatta ccccctttga aaagaatccc
     4921 tttgtgagat gcggcaccaa tacctccaaa gtatcctaat ggaatgctga ccactaatgc
     4981 gcaaggacat gatatgacta ggaatactaa agcccgatag aaccaatcat caaaaacaaa
     5041 aatgaattca ggttttatca gagagtataa ataggggagt atgacaacta gtatcgccag
     5101 tcctgtcact atcggtgtat aaattcgtgc aaaacggcgg ataaataatt cggcaggggc
     5161 ttttctttct gctgcatctt gtactaaagt gaggatacgt gctaacgtac tttgatcata
     5221 cggtttgttt actttgatcc gtaccacttt atctgaagcg atcattcctg ctaaaacttc
     5281 ttcttgttta tatagagtcc ggggaacact ttctccggtt agggtggccg tattaaatga
     5341 agcggaatct tccagtaaaa atccgtctag agatactttt tctccaactt ttacttcaat
     5401 ggtttctcct ggctgtactt tttccggtgc tgttatttta tatgtgttat tatatactac
     5461 agtggctgtt tcgggacgta catccaataa tgctttgatg ttgctgcgtg ctttgtgtac
     5521 agctttgtgt tggaaccatt cacctatgag atagaacaga ataacggcaa taccttccca
     5581 gtattctcct agatagaatg ctcctgatac agctatcccc attaaagtga attcattgaa
     5641 aactgattct aattttattt ttttcattgt ttctttttat ttatggcaac aaagatagtg
     5701 gaaagaagat gcaactaaat tgcaaattat attgtacttt tacatcgggt aattttttat
     5761 atacatgaaa aaaagatatt gggctttttt gataggaagc tggtgtttgt ctgtgggaat
     5821 gcaggcggcc aaagtggata ctttgtcggt acatagtgac gcaatgaata aggaggttca
     5881 ggtaattacc atctgtccgg ataaagccat ggcaggtgaa aaatgtcccg tactttatct
     5941 gcttcacgga tatggaggca atgcgggaac gtggctcggt ataaaaccgg aattacctca
     6001 aatagctgac aaggaaggaa tcatttttgt ttgtccggac gggaagaaca gttggtattg
     6061 ggacagccct ttgaataagg agtaccgtta tgaaacattc gtatcaaaag aattggtgaa
     6121 ctatattgat aagaatttta ctacgaaagt ggagagaggg ggacgtgcta tcaccgggtt
     6181 aagtatgggt ggtcatggaa gtttatggtt gtccatccgt cataaagatg tctttggagg
     6241 aggaggtagt atgagcggag gtttagatat ccgtccgttt cccaataatt gggagatgaa
     6301 gaagcaatta ggcgaagaag cgagcaacaa gcagagatgg gacgaacata cggtaattaa
     6361 tcagttggat aagataaaaa atggtgatct ggctgttata atagattgcg gttgtgatga
     6421 tttctttctg gaagtgaata aggttgtaca cgaaaaactg ttgaagaaga aaataaatca
     6481 tgactttatc atccgtccgg gcgggcatac aggcaggtat tggaataatg ccatagacta
     6541 tcaaatacta tttttcagta agttctttaa taaatcgaaa taataaaatg gataaaattg
     6601 tttttattac aggagcttcc agcggtatcg gtgccggatg cgctcgcaag tttgcttcac
     6661 agggagcaag tttgatttta aatgctcgta acgtaaataa actgagtgca ttgaaagaag
     6721 aattagaaaa gcaatatggt acggaaatat atttgcttcc ttttgacgtg cgcgaccgta
     6781 aggcggcaac gtctgctttg gaatcattac ccaaggaatg gcaatccatt gatatactgg
     6841 tgaataatgc tgggttggtt atcggtacgg ataaagaaca ggaaggtagt ctggatgagt
     6901 gggatattgt catagatact aatgttaagg ctttgctggc aatgacacgc ctgattgtac
     6961 cgggaatggt ggaacgtaaa cgaggacata ttattaatat tggttctatt gccggagatg
     7021 ctgcttatcc gggaggtagt gtgtattgtg ctacaaaggc cgctgtgaaa gctttatcgg
     7081 atggactgcg tatagattta gttgatactc cattgagagt gactaatatt aaaccggggt
     7141 tggtagaaac aaatttttca gttattcgtt tccgaggaga taaggaaaag gcggataatg
     7201 tatataaagg tattcgtcca ttgacgggag atgatattgc ggaaactgtt tattttgctg
     7261 cttctgtacc agaatatatg cagattgcag aaatgttggt tatgcctact tatcaagcta
     7321 cagggacaat tgtttcacgc aaataaaaga ggtagaagag atataaataa aggcgaccct
     7381 ttataaagcc gcctttattc ttaccttctc attttacctt cttaccttaa aaaacaatta
     7441 taattcaata atcaatgatt gacgtgcacc gactgtcata tttttggtaa ggtcaatttt
     7501 tttgccactg ataagttctt taccgctttt tgagtcattt gtcattatgc ggtagtggtt
     7561 attagccacc acttgttcgg cattggtgct gtttaggaca atgagttcag ttttcccaga
     7621 attagtacgt gcgtacatat atattccgtg ttggggaata tggtacttaa ctgttttctt
     7681 ttccatcttc gtttaattta gtttggtttt acggcggcaa atttatatgt ttttcagcat
     7741 atcttatata actaatcatt caaaattcat aataaatcat tcatttctta atctatatca
     7801 ataaaaaatc ctcttccaca tattagttga agaggatttt atttgttgtt gttcaatgaa
     7861 ttacatcaag aatccaagta aaataccggc tgctacggca gaaccgatta caccagctac
     7921 gttgggaccc atagcatgca tcagcaagta gttggtagga tcatattcca gaccaataac
     7981 ctgagagata cgtgccgagt cgggaacagc agatacaccg gcattaccga taagcgggtt
     8041 gattttgtta tccttaccta ataccaagtt gaatatcttc acgaagataa ctccagaagc
     8101 agtagcaatg atgaatgaca atgcacccag cgcgaaaatc aagatcgaat caatggtaag
     8161 gaactctgaa gcttgcgtgg aagcacctac tgtcaatcct aataagatgg taatggtatc
     8221 aatcagcgga ccgcgggcag tttctgctaa gcgacgagtt acaccgcttt ctttcaataa
     8281 gttaccaaag aaaagcatac ccaatagagg cagacccgac ggaaccagaa aacaagtaag
     8341 taacaaacca atgataggga acattacttt ttctgtatga gaaacgacgc gtggtggttt
     8401 catacggatc aaacgttcgt gcttggtagt gagcagacgc atgataggcg gctggataac
     8461 cggtaccaat gccatgtatg aataggctga taccgcaata gctcccatca ggttaggcgc
     8521 cagtttggat gaaaggaaga ttgctgtcgg accgtccgca ccaccgatga tgccgatagc
     8581 accagcctgc atcggatcaa agcccattgc caatgcaatc atgtatgcac cgaaaatacc
     8641 aaactgtgcg gcagcaccaa tcaacatcag tttaggattt gaaatcaatg ccgagaaatc
     8701 cgtcattgca ccgataccta aaaagataag tggtggatac catccggagg taactccttg
     8761 atataaaata ttaagaacag aaccttcctc atagatgccg actttcagtc cagcttccat
     8821 gttgaaagga atattaccga tcaagatacc aaaaccgata ggaatgagca acatcggctc
     8881 aaattccttg gccacggcaa ggtatatgaa gaataaacct atcaggatca ttacgatatg
     8941 accaacagta gcattggcaa aacccgtata tgtccaaaag tcagctaggt tattccctaa
     9001 aaagttgata aattctccca tattattcaa taattacaag gtcagtacct tcgagaacgg
     9061 attctccttt acttacattg attgcggtga tcttgccgtc tttgtctgcg ttgatgttat
     9121 tctccatctt catagcttca aggataatga tggtttgccc cttttttacg gtatcaccaa
     9181 catttacctt aatatcaagg attacacctg gcaacggaga tttaacgccc gattttcctg
     9241 tagaagttgc agcaggcttt actactgtag ttggagccgg agcagggctg gttgatgcag
     9301 gacgaactac cggtttcact acagctttcg gggctttttc catttctact ttgtaaggag
     9361 tgccgtttac ttcaacatga gcgatattat cttctatatc tccaatggca accttatata
     9421 tgttaccgtt aatcttatat ttatattctt tcatcgtttt atctttttat tggtgactta
     9481 ctttttgtgg ggagtttcac gcaaggtata aatcttagaa ctccacggtg aatagctacg
     9541 ttttacacga gtaatggtaa gaacagtttc ttctacatcg tgtacatcgc tttgcatttc
     9601 gtgcatagcc atggcaattg cggcgaatac ttcgcctgga gcttcaccca gtttcttttc
     9661 tttggcttct tgtttgtcgg taataccttt taccttcatg gcattgcgct tgctcaggtt
     9721 gacagaaata cggcctataa ctttgaaagc aataaacaga aggagcaagc ctacgaatac
     9781 gacactcata gctgatatgg acataccaat acccacactg tcatgttctt caaacttttc
     9841 catcttagcg ttgctgttga tagtcttgtt gttagtgcta ggagttacat acttgtctgc
     9901 actagaacct tttacttccc attcatttgc agcgtcgctg acacgtgcgt atgattggtt
     9961 tgcctgtaat gtacctgcag gaactataat ctgatccaat aatttcttgc ctgaatcata
    10021 caagccgatc caattgttcg ttgcggcatt cagggtgaag ttggtgtgga aagtaccacg
    10081 gttaggttca ccatctgccc agaacaaagc gtgctggcga ggtttgatca aagtcaatac
    10141 atcaccttta gggataaaat aagtagcagt atctccaggc tggctgctca ccttcagtaa
    10201 acaaccggca aggtctgcgc taccaaatga tctattgaat atttcaatcc atgcgctgtg
    10261 tactccgtag tcatcttgga aattgctttc attttcaatc agcacttcat tcagtaccag
    10321 cttggtgttt gatttctgtt ctccacaaga acataaaccc accatcagca gcaaagaaag
    10381 gaatattcct atatttaatt tcttcatgtt caattctcaa tttttaattt ttaattaaag
    10441 aggaatatta ccatgcttct tagccggatt ggttaatttc ttagtttgca actgttgcaa
    10501 tgcacggatg atgcggaaac gggtattacg cggttcaatc acatcatcaa tatagccata
    10561 tttggcagca ttgtaaggat tggcgaacag cttggtgtat tcagcttctt tttcggctag
    10621 gaatgcggca ggattttcct gttctttggc ttcgcgggcg tataatactt ctactgcacc
    10681 tgcaccaccc ataacggcga tttcggcagt aggccatgca taattcatat caccgcgaag
    10741 ttgtttacag ctcattacaa tgtgagatcc gccgtatgat ttacgcaggg taattgttac
    10801 tttgggtaca gtcgcttcgc cgtaagcata cagcaacttg gcgccgtgga ggattacgcc
    10861 gttgtattct tgtcctgtgc ctggaaggaa tcccggaaca tctaccaatg aaacaagagg
    10921 tatattgaaa gcgtcgcaga aacgtacaaa acgcgcacct ttacgtgacg cattgctgtc
    10981 aagtacaccc gccaggtatt ttggctggtt tgcaacaata cctacagatt gtccgttgaa
    11041 acgtgcgaaa ccaatgatga tatttttagc gtagtgaggt tggacttcca aaaactcacc
    11101 attatctacg atggcgctga tcacctcata catatcgtat ggtttgttgg ggctgtcggg
    11161 gataatttcg ttcaaagagt cttccagacg gtcgatagga tcggtacagt ctacataggg
    11221 agcttcttcc agattatttt gaggaatata gcttaacaat ttgcggatca tggctaaccc
    11281 ttcttcttcc gtcttggcag taaaatgagt aacaccggat ttggtagaat gaacgcttgc
    11341 accacctaag ttttcttggc ttacatcttc acctgtaaca gtctttacca ctttcggtcc
    11401 ggtaaggaac atgtatgatg tgccttccat catcaatgtg aagtctgtca gcgcaggaga
    11461 gtaaacagct ccgcctgcac aaggaccgaa aatacctgaa atctgtggaa taacacctga
    11521 agcaagaata ttgcgttgga aaatttcagc ataaccggcc agcgcattga taccttcttg
    11581 aatacgtgcg ccacccgagt cattgatacc gatacaggga gcacccattt tcatggcttg
    11641 atccattact ttgcagattt tcagagacat tgtttctgac agagaaccgg cagaaacagt
    11701 gaaatcctgt gcaaagatgt aaactaaacg tccttctatg gtaccacaac ctgttactac
    11761 accgtcgccc ggataatgtt ttttctccat gccaaaattg gtgcatctgt gttccacaaa
    11821 catatccatt tcttcgaaac tgccttcatc cagcaacatg gctatgcgtt cgcgggctgt
    11881 atattttcct ttttcatgct gttttgcaat tgctttatca cctccaccca tgcgtgctgt
    11941 agcccggcgt tcgataagct cttttatttt ttcaagttga ttgctcattt tacttatgat
    12001 tttacaattt acgattaaaa aatatttcta tttacgcttg aaccagacta aatacactga
    12061 tttcaattgt gaatagtcag atctcgtgtt ttatggtttt tcgcaaagct cagtcaggac
    12121 acccaaagtt gatttgggat gtaaaaaagc aatttgcaaa ccttcagcac ctttacgcgg
    12181 agctttgtca atgagacgga tgccagtggt ttccgcttcg gctaacgcat ttgccacacc
    12241 atcttccact gcaaaagcca aatgatgcat accaccgttg ccattatttt tttcaatgaa
    12301 ctttgcgata gtgctttcgg ggcttgtagg ttccagcagt tctattttaa catcacctac
    12361 tttcagaaaa gcggttttaa ctttctgatc ctctactgtt tcgatattgt agcatttcag
    12421 acctaatacg ttttcataat acggcagggc ctcttcaatg ctctttacgg caatgcccag
    12481 gtgttcaatg tgtgagattt tcatgatctt ataattttaa tagtttggtt ttatactcaa
    12541 gttttcagat aaaactgcac aaagaaagta atttcgagtt aaataaagaa atatttcttc
    12601 aattttattt cttatttgcg agatgcttca caacacttta gacaaaaaga caaaaatgaa
    12661 ttaaatatag aatttgcaca agagtttgtt cagccacttc caactgaagc ggaaccagcg
    12721 gcgtgtactg ctctgcttgc cgccaaagcg gagtataaag tccctgtaac cgtgcttttt
    12781 gaacggtaat cctgcatcca tgaattccaa atgtgcatat cctttttcgt gagcataggt
    12841 aataggtgcc catacggcta gaataccggg gtaaagaaaa gcataggttt tccgcatacc
    12901 tcctgagaac cacagataag cactttcttt tgagaaaaga cagatagaac cacctatgat
    12961 tttgccttta tatttcacaa gaaacacttt ggctaattct ttttctgggt tttgccatgc
    13021 taatagccgg aaaaagccga tgtccgggaa atgttttctt acctgtgagg aataggcttt
    13081 tttcaacatt cgtgagaaat cttgaatatc tttctcattg tcggctactt ccatgatggc
    13141 accgtttctc aacgctttgt ttatttgtct tttgcgagac atgctcagcc gttcgtaagg
    13201 gactttactg tgcagtgagt tacgtactct tagccaatta atggcgaaat agttgttctt
    13261 tctgaaagct ttgtatccga atagcggatt ttccaagttg cggaactcga tgaggaacga
    13321 tttgcataat acttcgttgg tgagatgttc caacatttcc ccgaacaggt cttccttatt
    13381 ctgttcttca tcaaaatact cgcctgtgcc ataaatctcg catcgtttga tgattgcggg
    13441 ggggaacaag cgcatactct tccggatgac agccagcagt ttgcctacag gacggtttcc
    13501 tatataggct acgataagca gaggttcgta tccccgagtc atttcaaaga catgaaataa
    13561 ctcggtagaa tggaaaatgt ttgttccagg cagaggggga atggcatttc ctttgcgata
    13621 tgtacttaat ctgacaggca tctctaattg caaatttatt gttttttgtt tatcaatcca
    13681 cattctagtt gtatatttgt gcagaaaaat aaattaactg agtatattat ggaacaattt
    13741 agtgacttaa taaagaacag acgcagtatg cgtaagttca cggatcaaga gttgacacag
    13801 gaagaggtgg ttgctttgtt gaaggctgct ttgatggctc cgtcttctaa acgtagcaat
    13861 tgctggcagt ttcttgtggt agatgataag tatatgctgg aaaaactttc ccattgtaag
    13921 gagatggggg cagcttttct agcggatgct gctatggctg tagttgtgat ggctgatccg
    13981 ttggctagtg atgtttggat tgaagatgcg gcaattgctt ccataatgat ccagttgcag
    14041 gcagaagatt tggggttggg aagttgttgg atacaggtgc gtgaacgttt taccgctacc
    14101 gggatgccct cgggtgaata cgtgcataca ctgcttgata ttccgttgca gttgcaggtg
    14161 gtttccatta tagcggtagg acataagggc atggaacgca agccttttaa tgaggaccat
    14221 ttgcaatggg agaaaattca catcaataaa tttggaggca agtaaacgtg gctgctgtca
    14281 atcataagga tacgtataaa gcttctgcgg tgtttctcat tgtgatgggt atgctttatc
    14341 tgatcgataa gtttatagga tttgcctcac acgggttgcc atgggttatg cagaaagaca
    14401 atctgttact gtatgcagct gttattttcc tttggttcaa ggccgataag tcagtaggaa
    14461 ttgtattggc gggtatatgg ctgatattga atatcagttt ggtgatagct ttgttggggc
    14521 agatgtctgc ttatttgttg ccggcggctt tgttgttgtt aggagttatt ttatatttag
    14581 tttcgacccg atgatgaaaa tagttctgat aggagctggc aatgtggcta cccatttggg
    14641 aatcgcttta caaaaggcag ggtgtcttat tttgcaggta tacagccgta cagaggagtc
    14701 tgcttctgca ttggctgaca gacttttagt agactacaca attgtgccgg atgagatacg
    14761 tcgggatgcc gatttgtata ttgtagcgct gaaagatgca gttttgcgac aattggctcc
    14821 tgtattggtg aaaggaaggg agcaggcttt gtttgtacat acggcgggta gtatgcctat
    14881 ggatttatgg aaggggttgg taaaacgcta tggggtactt tatcctatgc agacttttag
    14941 caagcagcgt gaagttgatt tcaataccgt accttttttt atagaagcat ctgctccggc
    15001 agaagtggga gtgctgcgta tggtggcagt tcgtctcagt cctaaagtgt atgaagtgac
    15061 ttccggtcaa cgtaggcatt tgcacctggc ggcagtcttt gcttgtaatt ttgctaacca
    15121 tatgtatgca ttaagttcac atatactgga aaagcagggg atttcttttg aagtgatgct
    15181 tccgctgata gacgaaactg ccggcaaagt acatgaactt tctcccacac aggcgcagac
    15241 aggtccggct gtacgctacg atgaaaacgt aataagcaaa catttggaga tgttggcgga
    15301 tgaggagtct ttgcaggaat tgtacgaaaa gataagtaaa agtattcatg atctcccttt
    15361 gtctgttatt cagacaaata aagagggaaa gaactcataa gtggtatgat aaactatgat
    15421 ttaaagaaaa taaaggcatt ggtatttgat gtcgatgggg tattgagtgc ggaaactatt
    15481 tatttgcacc ccaatggtga acccatgcgt acggttaata tcaagga
//
