LOCUS       c00581_gnlPro..        13152 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ODKNMFEK_581.
ACCESSION   c00581_gnlPro..
VERSION     c00581_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 14:46:20
            Original ID  :: gnl|Prokka|ODKNMFEK_581
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13152
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13152
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1095:7082]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1096..7082
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13152
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13152
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             311..685
                     /locus_tag="ctg581_1"
                     /transl_table=11
                     /translation="MKRLVLLVVVALGMSATSFAGEKVEGKDWKVDVNVAKLSKYLNLD
                     ARQMEEVANISDYFADKVQSASYAKEAKQGKKLREAVYGNFKLMKRTLTNEQYKKYVQL
                     LNVTLKNKGLDSYMEDVANK"
     CDS             1096..2898
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg581_2"
                     /sec_met_domain="ILVD_EDD (E-value: 2.1e-217, bitscore:
                     712.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFT
                     QFVPGHTHLHEIGQQVKVEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNNQHLDLID
                     AMIKSADASVSDEDVAQIENNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATH
                     ANRTQLFKDAAALIVKNAYKYYEEGDDSVLPRNIATRDAFLNAMTLDIAMGGSTNTVLH
                     LLAIAHEAEVDFKMDDIDMLSRHVPCLCKVAPNTQKYHIQDVNRAGGILNILGELSKGG
                     LLKTDVKRVDGLTLAEAVEKYNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELD
                     TDRANGCIRDLQHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPNRSINVKLSDEELAARPMTPVTRDRK
                     VPKSLKAYASMVSSADKGGVRIID"
     CDS             2999..4696
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg581_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-49, bitscore:
                     156.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHRNT
                     LNHILVRHEQGAAHAAQGFARVSGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPVVLD
                     FAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGN
                     AQDELRAFIEKADMPCGCTLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVG
                     MRFDDRVTGKLDTYAKQAKVIHLDIDHSEIDKNVKVDVPVLGNCKYTLAMLTQLIRKNE
                     HSEWIDSFTEYEKTEYEHVISKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQM
                     MAARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIILLNNNYLGNVRQWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVM
                     KREELQAAIHEMLTTDGPFLLEACVIEEGNVLPMTPPGGSVNQMLLEC"
     CDS             4707..5261
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg581_4"
                     /sec_met_domain="ALS_ss_C (E-value: 1.5e-19, bitscore:
                     59.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENIAGLLNQITAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTTQDVIEKVVKQIEKKIDVLQAHYFTDSEIYQHEIALYKVSTPEFQENPM
                     ASKVIRRYSARIVEVNPVFSIVEKNGMSEEITALYEELRGLGCVLQFVRSGRVAITTSC
                     FERVNEYLTQREEKYRQQKTE"
     CDS             5261..6004
                     /locus_tag="ctg581_5"
                     /transl_table=11
                     /translation="MMSENKVGTYRFVAEPFHCDFSGKLTMSVLGNHLLNCAGFHAADR
                     GFGIATLNENHYTWVLSRLAVELENMPCQYEGFSIQTWVENVYRLFTDRNFAILDKEGK
                     TVGYARSVWAMISMETRKPADLLTLHGGSIIDYVCDKKCPISKPGRIKVTEKAPVSEYQ
                     TRYSDIDINGHVNSIKYIEHILDLFPIEFFKEKRIKRFEMAYVAESYYGDILSFYREEV
                     EEKEYDIEVKKNGTDVVVRSKVIFI"
     CDS             6039..7082
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg581_6"
                     /sec_met_domain="IlvN (E-value: 1.2e-46, bitscore: 148.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.4e-41, bitscore: 131.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKATIVMCLLSDAAVMS
                     VWPTIKPYLTQGKALYFSHGFAITWSDRTGVVPPTDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDVTGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHSPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             7210..8295
                     /locus_tag="ctg581_7"
                     /transl_table=11
                     /translation="MNNRLSLLLIGCIFPFLSFYAQKNMNLPPYYPTVKGITDYAVWQL
                     VYPDSLLRANIAGEAVCTLRIDSLGTVRCKYIEATHPLFAKAAEDVIEGMREWQPAKKA
                     GRDIDTTIVFHIPFNPDVYSDRIWRQQQVLESCRGQLVDSMPVFPDDIRSLVMGNMSWP
                     DDKVDKAVAICRFTVNEKGEIVDIRVIKGTHPAFDKESIRILSNFPRLIPAMKNRKSVP
                     YDYFLTMRFWKEDLEHYLLYRECAQEDLEKITWEPYRYSSYPGGTVALTQFINSHLKIT
                     PEMKATGKQGRVIYSFNVDIDGSMKDFQLVRGLDPLMDAEALRVLQLVNERWSTGYYFN
                     SKKWYREFYVNQFTIPIIFSW"
     CDS             complement(8389..9603)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OAD_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg581_8"
                     /sec_met_domain="OAD_beta (E-value: 9.3e-113, bitscore:
                     366.3, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENIDFGILFQGIGTMIESGWFLACARVFLILLGFLLIYLGWKGI
                     LEPMVMIPMGLGMIAINCGTLIMPDGNLGNLFLDPMLSDTDELMNTMQIDFLQPVYTLT
                     FSNGLIACFVFMGIGTLLDVGFLLQKPFASLFLALCGELGTFLTLPIANALGLSAQESA
                     SVAMVGGADGPMVLFTSLALAKHLFVPITVVAYLYLGLTYGGYPYLVKLLIPKRFRSIK
                     MTVKKAPKNYDAKVKLAFAAVLCAVLCFLFPVASPLFFSLFLGVAVRESGMKHIYDFVS
                     GPLLYGSTFMLGLLLGVLCDAHLLLDPKILKLLILGMLALLLSGIGGILGGYIMYYIKK
                     GNYNPVIGIAAVSCVPTTAKVAQKIVSKDNPDSFILGDALGANISGVITSAIITGIYIT
                     IIPLL"
     CDS             complement(9625..10068)
                     /locus_tag="ctg581_9"
                     /transl_table=11
                     /translation="MLHLFLSTLAMMGLTFLIGFFVAAIIKGIALAADSMDFYSSHLLE
                     LQRLRKIKKARARFIQLVWNNSPEEMEALGDSRENWNRGMNSDLRGKQEGGYYHGVSHG
                     ASQLNLIDYYYPDTKMIYLKKREEMHNQQQKSTHVKKNLSMNK"
     CDS             complement(10223..10630)
                     /locus_tag="ctg581_10"
                     /transl_table=11
                     /translation="MFAIVIMKYFIAICTCILLLCSFNSTNKGGIIRECPPEVISSISM
                     LSDDTNSYRQLSTEKRYDAPNVKLSEVNLLCFTLRTPMFTKTSKPLSTIKVLCHYRILL
                     PEQKFNSLYPSINYVKSSCKYFIYTLGHILI"
     CDS             complement(10781..12913)
                     /locus_tag="ctg581_11"
                     /transl_table=11
                     /translation="MATLQTIRSKGPLLVVVIGLALFAFIAGDAWKVLQPHQGKQDVGE
                     VNGKTLTAQEYQKMVDEYTEVIKLTQGVSALNDDQLTQVKDQVWQSYVNNQLIAAEAAK
                     LGLTVSKAEVQAIIEEGTNPLLMQTPFRNPQTGAFDKDMLKKFLVDYAHLDASKMPAQY
                     VEYYQKMGAFWNFIEKTLIQSTLAEKYQNLIAKSLISNPVAAEDAFISRTEQSDVLLAA
                     IPYSSISDSTITVSNSEIKDLYNKKKGSFEQPVETRNIKYIDVLVTPSDEDRKEVLNEV
                     TEYATQLGTAADMNTFIRSTGSVVPFSEIAINKTVYPNDVVARLDSVTINEVYGPYYNQ
                     ADDSYNAFKIIAKQTAPDSIQYRQIQVYAEDAAKTATLADSIFNALKGGADFTDIAKKY
                     GQTGEATWLTARNYEGAALDADNAKYINTLINSNVKELTNLQIGQANVILQVLDKKAMK
                     DKYKVAVIKRPVEFSKETYNKAYNDFSQFVAQNTTMDKIIANAEESGYRLLERADFRSA
                     EHRVGGVKGTREALKWIFAAKEGEVSPLYECGENDHLMVVALEKINPAGYRNINLVADM
                     LKAEIIKDKKAEKLIAEMKSASSIDQVKSMANAVSDSVKHITFSAPAYVSVTRASEPAL
                     GAYASKAEINKLTGPIKGNAGVYMIQVYNKEKSAEEFDAKNEENNLSNMAGRYASSFIN
                     DLYKKADVKDDRYLYF"
     CDS             13082..13150
                     /locus_tag="ctg581_12"
                     /transl_table=11
                     /translation="MEFIENDLFMYFGETLVLVQDES"
ORIGIN
        1 tttgttggca aagatacgaa ttaattcccc ttaatccttt gttattacgt ttatattaca
       61 taaatttgtt attatgatac tataaatgcg cttttgattg cgtttgatcc ttgatataaa
      121 tcaattaacc gctcgccttg atagattttt gctttaatta acggatatat gacaacatgt
      181 cgtaaagcat gttgttatat ttgcagtgta aagagaaaga gataacgaga ttgtttttaa
      241 aaggtattat ttagttctta ggtactaaat aaattgtttt taggtttaac aaattaaaat
      301 tttaggtatt atgaaacgtt tagtattgtt ggttgtagtg gcattaggaa tgtcagctac
      361 aagttttgca ggagaaaaag tagaaggtaa agattggaag gtagatgtta acgtcgcaaa
      421 gttgagcaaa tatttgaatt tggatgcacg tcagatggag gaagttgcta atatttctga
      481 ttattttgct gacaaagtac aaagcgcaag ctacgcaaaa gaagctaaac aaggtaaaaa
      541 attgcgtgaa gccgtatatg gaaacttcaa actgatgaaa cgtacattga caaatgagca
      601 gtacaagaag tatgtacagt tgttgaatgt tacattgaaa aacaaggggt tggattccta
      661 tatggaagat gtggcgaata agtaaattta taaaatgaaa taaatgaact gaaaagagaa
      721 tgcaaaccaa tgcattctct tttttattta tccgttggaa gatacagtgt atatttgtga
      781 taaaatgatt gtttaaagct cgatttagtt acgaataata atttataaga aaaaaaatct
      841 tcattttatt tgtttgttac gaaaaacgcc ttacctttgc agtcgttaaa gaaacaaaga
      901 aaacagatat atgaatatta ctactctaaa taacctagca gtcctgcata ttattcgcgt
      961 cgtggtggtc acactaggag cgtgagaaag gttgtgtatg tgtagttgta catataaaga
     1021 aataattgga agcctttctc acatggtgag gaaggctttt tcaataagta taggacgtta
     1081 tagatttaga ataagatgaa gaatcagtta cgcagttcgt ttagcacaca gggtcgccgt
     1141 atggcaggag cgagagcttt atgggtggct aacggcatga aaaaagaaat gatgggcaag
     1201 cccattatag ccatagtaaa ttcgtttaca cagtttgttc cgggacatac ccatctgcat
     1261 gaaataggtc agcaggtgaa agttgagatt gaaaaactgg gatgttttgc agcagaattc
     1321 aatacgattg ccattgatga cggaatagct atgggacacg atggtatgct gtattcactg
     1381 cccagtcgtg atatcattgc cgacagcgtg gaatatatgg tgaatgctca caaggcggat
     1441 gcaatggtgt gtatcagtaa ttgtgacaaa atcactccag gtatgctgat ggctgccatg
     1501 cgactgaaca taccggctgt ttttgtatcg ggtggtccta tggaagcggg agaatggaat
     1561 aaccagcatc ttgatttgat agacgccatg attaaatctg ctgatgcatc ggtcagcgat
     1621 gaggatgtgg ctcaaattga aaataatgcg tgtcctggct gtggttgctg ttcgggtatg
     1681 tttacggcta attccatgaa ttgcctcaat gaggctattg gtctggggct tccggggaat
     1741 ggcactattt tggcgactca tgccaaccgt actcagttgt ttaaagatgc ggctgctctg
     1801 atagtgaaga atgcttataa atattatgag gagggagatg acagcgtgtt accacgcaac
     1861 attgctactc gtgacgcttt tctgaatgcc atgacattgg atattgcaat gggtggttct
     1921 accaatactg tgctccatct tttagctatc gcccacgagg cggaagtaga tttcaagatg
     1981 gatgatattg atatgctttc acgccatgtg ccttgtttgt gtaaagtagc tccgaataca
     2041 cagaaatatc atatccagga tgtgaaccgt gccggtggta tccttaatat attgggagaa
     2101 ttatccaagg gtggtttgct gaaaactgat gtgaaacgag tggacggcct gacattggcg
     2161 gaagctgtcg aaaaatataa tatatgtaag aaagaagtgg atactgaagc aaaacgtatt
     2221 tattcaagtg ctccgggaaa caaattcaat ataaagttag gttctcagaa tgctgtttat
     2281 aaagaactgg atacagatcg tgccaatggt tgtatccgcg atttgcaaca tgcctatagt
     2341 aaagatgggg gtttggccgt tttgaaaggg aacattgcac aggatggttg cgtagtgaaa
     2401 acggccggag tggatgaaag tatttggaaa ttctcggggc ctgccaaggt gtttgattcg
     2461 caggatgctg cttgtgaagg tattttagga ggaaaagtag tcagcggaga tgttgttgtt
     2521 atcactcatg aaggtccgaa aggtggtccc ggtatgcagg aaatgcttta tcctacttcc
     2581 tatatcaaat ccaagcattt aggaaaagaa tgtgctttga ttaccgacgg acgttttagt
     2641 ggaggaactt cgggattaag catcgggcat atttctcccg aagctgcagc gggtggtaat
     2701 atcggaaaaa tagtggatgg tgatataatt gaaatcgata ttccgaatcg cagtatcaat
     2761 gtgaaactga gtgacgaaga attggccgcc cgaccgatga caccggtgac ccgtgaccgt
     2821 aaagttccta aaagcttgaa ggcatacgct agtatggtaa gttctgcaga taaaggagga
     2881 gtgagaatca ttgactaaat tagaaattaa aaattgagaa taaaaaaata gatttgttgt
     2941 cattggtcga ttgtccggca tcgtattttt ttgattctca attctcaact aaacaattat
     3001 ggcaaaagaa aagataacag gagcagaggc gatgatgcgt tctttggagt atcaaggagt
     3061 gaaaactctt ttcggatatc ccggaggttc tatcatgcct acttttgatg ctttatatca
     3121 tcatagaaat acattgaacc atatattggt ccgtcatgaa caaggagctg cccatgcagc
     3181 acagggattt gcccgcgtat ccggtgaggt tggtgtctgt ttggtgacta gcgggcccgg
     3241 tgcgacaaat accattactg gcattgccga tgctatgatt gacagcacgc ctatcgtggt
     3301 gattgccggg caggtaggag cttccttttt aggtacggat gcttttcagg aagtggatct
     3361 ggtgggcatc actcagccta ttaccaaatg gagttaccaa attcgtcgtg cggaagatgt
     3421 agcttgggct gtagcccgtg ctttctatat agctaaaagc ggacgtcccg gtcctgtcgt
     3481 tttggacttt gccaagaatg cacaagtgga gatggtggat tatgaaccga tgaagcttga
     3541 ttttatccgt agttatgatc cagaacctaa tcctgataag gaatctcttc aggaggctgc
     3601 cgaattgata aacaatgctc aaaggccatt agtgttggta ggacaggggg tagagttagg
     3661 taatgcgcaa gatgagttac gtgcatttat agaaaaagcc gatatgcctt gtggctgtac
     3721 tttgctggga ctttcggcta taccaacttc gcatccttta aacaaaggaa tgttaggtat
     3781 gcatggaaat ctggggccca atgtcaaaac taatgaatgt gatgtgttga ttgctgtagg
     3841 tatgcgcttt gacgatcgtg taactggaaa attagataca tatgctaaac aggcaaaggt
     3901 gattcatttg gatattgacc attctgaaat agataagaat gtaaaagtgg atgtacccgt
     3961 attaggtaat tgtaaatata cgctagctat gctgacgcaa cttatccgga agaatgaaca
     4021 ttccgaatgg attgatagct ttactgaata tgaaaagacg gaatatgaac atgttatcag
     4081 taaagaaatt catcctgttg acggggcgtt gaatatgggt gaagtggtgc gtgcggtaag
     4141 tgaggcttcg aacaacgagg ctgtattggt gacagatgta ggacagaacc aaatgatggc
     4201 tgctcgttat tttaaataca gtaagaaccg tagcattgta acttcgggtg gattgggaac
     4261 gatgggattc ggtcttcccg ctgctatagg cgctactttc ggtcgcccgg atcgtactgt
     4321 atgcgtattt atgggggatg gcggtttgca gatgaatatt caagaattgg gaactatcat
     4381 ggagcaaaaa gcaccggtaa agattatttt attgaacaat aactatttgg gtaatgttcg
     4441 tcaatggcaa gctatgtttt ttggtcatcg ttattcattt actccgatgt tgaatccgga
     4501 ttatatgaag attgccgagg catatgagat tcctgcccgc cgtgttatga agcgtgagga
     4561 attgcaggct gctatccatg aaatgttgac tactgacggg ccattcctgc tggaagcttg
     4621 tgtgatagaa gagggaaatg tgttgccgat gacacctccg ggaggctcgg tgaatcagat
     4681 gttactggaa tgctaattta ataattatgg acaagacatt atatacatta atcgttcatt
     4741 cagaaaatat cgccggtttg ctgaaccaga ttacggcagt gtttactcgc cgccaaatta
     4801 atatcgaaag ccttaatgtt tctgcatctt ccatcaaggg ggtgcataaa tatactatta
     4861 ctgcttggac cacccaggat gtgatagaaa aagtggtgaa gcagattgaa aagaaaatag
     4921 atgttttgca ggcacattat tttactgata gtgagattta tcagcatgag attgctttgt
     4981 acaaggtttc tactcctgaa tttcaggaga atcctatggc atctaaagtt atccgccgtt
     5041 atagtgcccg cattgtagaa gtgaatccgg ttttctctat tgttgaaaag aatgggatga
     5101 gtgaggaaat tactgctctt tatgaggagt tgcgcggatt gggatgtgtg ttgcagtttg
     5161 tccgttcggg acgtgtggcc attactacca gctgtttcga gcgtgtgaac gaatatctga
     5221 cccaacgcga ggaaaagtat cgccagcaaa aaacagaata atgatgagtg agaataaagt
     5281 aggaacatac agatttgtgg cagaaccctt tcactgtgat ttcagtggaa agttgaccat
     5341 gagtgtgttg ggtaatcatt tactgaattg tgccggcttt catgctgccg accggggttt
     5401 cggaattgct acgctcaatg agaatcatta tacatgggta ctttcccgtt tagctgtaga
     5461 gttagagaat atgccctgtc aatatgaggg tttcagtatt cagacatggg tagagaatgt
     5521 ttatcgtctt tttacagacc gtaattttgc aattttggac aaggaaggaa agactgtcgg
     5581 atacgcccgt tctgtatggg cgatgatcag tatggaaact cgcaaacctg ctgacctgct
     5641 tacgcttcac ggaggtagta tcattgatta tgtatgcgat aagaaatgtc ctataagcaa
     5701 gcccggtcgt attaaggtga cagagaaagc tccggtttct gaataccaga ccagatatag
     5761 cgatattgat attaatggtc atgtgaacag tattaagtat atagaacata ttctcgattt
     5821 gtttcctata gagtttttta aagagaaacg gattaaacgt tttgagatgg cttatgtagc
     5881 tgagagttat tatggtgata tattgagttt ctaccgcgag gaagtggagg agaaagaata
     5941 tgatatagag gtgaagaaga atggcacaga tgttgtcgtt cgtagtaagg tgatatttat
     6001 ttagaatcta atttttaatt tttaatttat aatttaaaat ggcacaattg aattttggcg
     6061 gcgttacaga aactgtagtt atccgcgatg aatttccttt ggaaaaagca cgtgaagtat
     6121 tgaaagatga aacaatcgct gtgatcgggt atggtgtaca gggaccgggg cagtctttga
     6181 atctccggga caatggtttc aatgtaattg ttggtcagcg tccgggaaaa acatatgaaa
     6241 aagcagttgc tgacggatgg gttccgggtg aaactctgtt tggtattgaa gaggcttgtc
     6301 agaaagcgac tatcgtaatg tgtctgttat ctgatgcagc tgttatgtct gtatggccga
     6361 ctatcaaacc ttacttgacc caaggcaagg cactttattt ctctcatggc tttgccatta
     6421 cttggagtga ccgtacaggg gtagttcctc ctactgatat tgatgtgatc atggtagctc
     6481 ctaaaggttc gggtacttca ctgcgtacca tgttcttgga aggtcgtggc ttgaactctt
     6541 catacgctat ctatcaggat gtaaccggta aggcttatga acgtactatt gcattgggta
     6601 ttggtatcgg ttcaggctat ttattcgaaa cgactttcca gcgtgaagca acttctgacc
     6661 tgacaggtga acgcggttct ttaatggggg ctatccaagg attgttgttg gctcagtatg
     6721 aagtattgcg tgaaaacgga catagtcctt ctgaagcatt taatgaaact gtagaagaat
     6781 taacccagtc attgatgcct ttgtttgcta agaatggtat ggactggatg tatgctaact
     6841 gctctaccac tgctcagcgc ggtgcattgg attggatgac cccatttcac gatgctatca
     6901 aacccgtagt tgaaaagtta tatcacagtg tgaagactgg caacgaggct cagatttcta
     6961 tcgattctaa ctctaaaccc gattatcgtg aaaaattgga agaagaattg aaggcattgc
     7021 gtgaaagcga aatgtggcag actgctgtaa ccgtacgtaa acttcgtcct gaaaataatt
     7081 aatagttagt atttaatgta gaaagcgggg atgcgatgag gtatctccgc tttcttttat
     7141 atatattaat gttagtggtg ttgtttatat catgtgtagt cgctaatttt gtgaaaactt
     7201 gacttaggca tgaataatag attatcactt ttattaatag ggtgcatatt tccctttcta
     7261 tctttttatg cacaaaagaa catgaatctc ccgccatatt atcctacagt aaaaggtatt
     7321 acggattatg ctgtgtggca gctcgtatat ccggattctt tattaagggc caatattgca
     7381 ggtgaagctg tgtgtacgct ccgcattgat agtttgggga ctgtccgttg taaatatatt
     7441 gaagccactc accccttgtt tgctaaggcg gccgaagatg tgattgaggg tatgcgtgaa
     7501 tggcagcctg caaagaaagc gggtagagat atagatacta ctatcgtctt tcatattcct
     7561 tttaatcctg atgtttacag tgaccgcatt tggcggcagc agcaagttct ggaatcttgc
     7621 agaggacaac ttgtcgattc catgcctgtc tttcctgatg atattcgtag tcttgttatg
     7681 ggaaatatga gttggcctga cgataaagtg gataaagccg tcgctatttg ccgttttacg
     7741 gtaaatgaaa aaggagaaat tgtggatatc cgtgtgataa aaggtactca tccggctttt
     7801 gataaagagt ccatacgtat tctttctaat tttccccggt tgattcctgc tatgaaaaac
     7861 agaaaatctg tgccatatga ttatttttta actatgcgtt tttggaaaga ggatctggag
     7921 cattatttat tatataggga atgcgcacag gaagatttgg aaaagatcac ttgggagcct
     7981 tatagatact cttcttatcc cggtggtact gttgctttga cgcaatttat taattctcat
     8041 ctgaaaatta ctcccgaaat gaaggctacg ggaaagcagg gacgggtgat ttatagtttc
     8101 aatgtggata tagatggttc aatgaaagat tttcagttgg tgagaggact tgatccatta
     8161 atggatgccg aagcattgcg ggtacttcaa ttagtgaatg aaagatggag tacggggtat
     8221 tatttcaatt caaagaaatg gtatcgggag ttttatgtga atcaattcac cattccaatt
     8281 atttttagtt ggtagtggtg gcagagggca gatacgcgga ctgccctctg cgaaaatgat
     8341 agcattatta aaagtggatg aaatttatta ggtaggattc atgctgtttc ataatagcgg
     8401 gatgattgtg atataaatac ctgtaataat tgctgaagta ataactcccg atatattggc
     8461 tcctagtgca tctcctagga taaatgaatc aggattgtct ttactgacaa tcttttgtgc
     8521 cactttggca gtagttggta cgcagcttac agcagcaatg ccaatgactg gattataatt
     8581 tcctttcttg atatagtaca tgatatatcc gcctaaaata cctccgatac ctgatagtaa
     8641 caatgccaac atacctagta tcagcaattt taagatttta ggatctagta gcagatgagc
     8701 gtcgcaaagc actcctaata ataatcccag cataaaagta gaaccgtaaa gcaatggacc
     8761 gctgacaaaa tcataaatat gtttcatccc tgattcacgt acagccactc ctagaaatag
     8821 agagaaaaac aggggagagg ccactggaaa aaggaagcag agtacagcgc agagtaccgc
     8881 tgcgaaagca agctttacct tggcatcgta attcttcggc gctttcttta cggtcatttt
     8941 gatggaacgg aaacgtttgg gaatcagtaa tttaaccaaa tagggataac cgccgtaagt
     9001 caatcctaaa tagagataag ctaccacggt aatcggtaca aacaaatgct tggctaatgc
     9061 caatgaagtg aacagtacca tcggaccatc tgcacctcct accatggcta cagaagcact
     9121 ctcttgtgcc gataagccaa gtgcattggc aattggcaat gtgagaaagg ttcctagttc
     9181 tccgcaaagt gccagaaaca aactagcaaa aggtttttgt agcaggaaac ctacatctag
     9241 caaggttccg attcccatga agacgaaaca agcgatgagt ccattactga atgtgagggt
     9301 gtaaaccggt tgcagaaaat ctatttgcat ggtattcatc aattcgtctg tatccgagag
     9361 catgggatca agaaaaagat tgcctagatt tccatccggc atgattaatg ttccacaatt
     9421 gatggctatc ataccgagtc ccattggaat catgaccatg ggttccaata ttcctttcca
     9481 acctagataa atgagtagaa atcccaaaag aattaaaaaa acgcgcgcac aggcaaggaa
     9541 ccaaccgctt tctatcattg taccaatgcc ttggaaaagt attccaaaat ctatattttc
     9601 catatctaat tgttgatttt caggttattt attcattgaa agattctttt tcacatgagt
     9661 gcttttttgt tgctgattat gcatttcctc ccgtttctta aggtagatca tctttgtgtc
     9721 cggatagtaa taatctatca gatttaattg ggatgctcca tgactgacac catggtagta
     9781 accaccttcc tgttttcctc tcagatcgct gttcattcct cggttccagt tttcacggct
     9841 gtctcctaga gcttccatct cttctggaga attattccat actaattgga taaaacgggc
     9901 acgtgctttt ttgatttttc ttaaacgttg aagttccaat aggtgggagc tatagaaatc
     9961 catagaatct gctgccagcg ctattccttt aataatagca gcgacaaaaa aaccgatgag
    10021 gaaagtaagc cccatcatgg ccaatgtgga taaaaataag tgtagcatta taatataaat
    10081 gtgatttagt aggtaaaata gtattaaatt ccgagttata gtgatattca catcgtagtg
    10141 tcacacatat atgtatacac gccgatagaa taatttcaat ccggaatgat aatgatcaag
    10201 aataagtaag aggaaatagc tgctaaatca aaatatgtcc taatgtgtaa atgaagtatt
    10261 tacacgagga ttttacataa ttaatgctag gatataggct attaaatttt tgttcaggta
    10321 gaagaatacg gtaatggcaa agtactttga ttgtagataa gggttttgat gttttggtaa
    10381 acatcggagt acgtaaagtg aaacataaaa gatttacttc ggatagtttc acattaggag
    10441 cgtcatatcg tttttctgta gataattggc gataggaatt cgtatcatcc gaaagcatgg
    10501 atatagaaga tatgacttct ggcgggcatt cgcggataat tcctccttta tttgtactat
    10561 taaagctaca taacaaaagg atacacgtac atatagcaat aaaatacttc ataattacta
    10621 ttgcaaacat aatgataaaa atgggaatac ggaacgtaaa cgaatagatt ttataaatta
    10681 tttcatcttt aatttttgcg aaaataggaa taagacaaaa caggctgtat cgacgaattt
    10741 tcgatacagc ctgttttgtc ttattgataa ctttctgata ttagaaatat aagtaacggt
    10801 cgtcttttac atcagctttc ttatacaggt cattgatgaa actgctagca taacgccctg
    10861 ccatattgga caagttgttt tcttcattct tggcatcaaa ttcttctgca ctcttttctt
    10921 tgttgtaaac ctgaatcatg taaacacctg cattaccttt gataggacca gttaacttat
    10981 ttatttcagc tttacttgca taagcaccta aagctggttc gctagcgcga gttactgaaa
    11041 catatgccgg agcagaaaaa gttatatgtt ttacagaatc gctaactgca tttgccatac
    11101 tttttacttg gtcaatgctg cttgcacttt tcatttcagc tatcagtttt tcagcttttt
    11161 tatctttgat gatttctgct ttcagcatgt cggcaacaag attaatatta cgatatccgg
    11221 caggattaat cttttcaaga gcaactacca tcaagtgatc attttcacca cattcataca
    11281 atggggacac ttcaccttcc ttggctgcaa aaatccattt caacgcttca cgagttcctt
    11341 ttacaccacc cacacggtgt tctgcgctac ggaaatcagc acgttctaac aagcgatatc
    11401 cgctttcttc tgcattggca ataattttat ccattgtagt gttctgtgct acgaattgac
    11461 tgaaatcatt gtatgctttg ttgtatgttt ctttgctaaa ttcaaccgga cgtttaatca
    11521 ctgcaacttt atatttatct ttcatagctt ttttgtccaa tacttgaaga ataacgttag
    11581 cttgtccgat ctgaagattg gttaattctt tgacattaga gtttatcaat gtgttaatgt
    11641 atttagcatt gtctgcatct aatgcagcac cttcatagtt gcgtgcagtc aaccaagtcg
    11701 cttcacctgt ctgaccatat ttttttgcaa tatcagtaaa gtctgctcca cctttcagtg
    11761 cattaaaaat actatcggct aaagttgcgg ttttagcagc atcttcggca tatacctgaa
    11821 tttgacgata ttggattgag tcgggagctg tctgtttggc aataatttta aaagcattat
    11881 atgaatcatc tgcttggtta tagtaaggac catatacttc gttgatagtt acagagtcca
    11941 aacgagcaac tacatcatta ggatatacag tcttgttgat tgcaatttca gaaaaaggaa
    12001 ctacagaacc ggtggaacgg atgaatgtgt tcatgtctgc agcagtacct agctgggtag
    12061 cgtattcggt tacttcgttt aatacctctt tgcgatcttc gtcagatgga gtaaccaata
    12121 catcaatata tttgatgtta cgagtttcaa ctggctgttc aaaagaacct tttttcttgt
    12181 tatacagatc tttgatttca ctatttgaaa ctgtaatagt tgaatcgctg atagaagaat
    12241 agggaattgc agctaataaa acgtctgatt gttcagtacg tgatataaaa gcatcttcag
    12301 ctgcaaccgg atttgaaatc aatgattttg caatcaggtt ctgatatttt tcagctaaag
    12361 tggattgtat caaagtcttt tcaataaaat tccaaaaagc tcccatcttt tgatagtatt
    12421 ctacatattg tgcaggcatt ttgcttgcgt ccagatgagc gtaatccact aggaattttt
    12481 tcagcatatc tttgtcgaaa gcaccggttt gcggattgcg gaacggggtt tgcatcaaca
    12541 atgggttagt accttcctcg atgattgctt gaacttcagc tttgctgacg gtcaacccca
    12601 attttgcagc ttccgctgcg attaattggt tatttacgta agattgccat acttggtctt
    12661 tcacttgagt cagttggtcg tcatttaatg cagaaacacc ttgtgtcaat tttatgactt
    12721 ctgtgtattc atctaccatt ttttgatact cttgtgctgt aagtgttttt ccatttactt
    12781 cacctacgtc ttgtttaccc tgatgtggtt ggagaacctt ccatgcgtct ccggcaatga
    12841 atgcgaagag ggcaagtccg attacaacga ccaacagagg gcctttactt ctgattgttt
    12901 gtaatgttgc catttaattt tactattttt gtttattgtt tttttatact tcatagattt
    12961 agcgcacgaa gatacaaaaa atgcagctta caagctattt tattgtgaaa aaaatctgtt
    13021 attcgattac tttcaacttt actaattcaa ttcttgttgc tgttacttta attattttga
    13081 aatggaattt atcgaaaatg atctcttcat gtattttggg gaaactttgg tattggtgca
    13141 ggatgagtcc ac
//
