LOCUS       gnlProkkaBCNCMMLM_93   13197 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BCNCMMLM_93.
ACCESSION   gnlProkkaBCNCMMLM_93
VERSION     gnlProkkaBCNCMMLM_93
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 08:29:20
            Original ID  :: gnl|Prokka|BCNCMMLM_93
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13197
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13197
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1173:8197]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1174..8197
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13197
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13197
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(2..349)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg93_1"
                     /sec_met_domain="Polysacc_synt (E-value: 1.7e-21, bitscore:
                     69.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLHSIFKNSLYKGALNFFNLVLPLLVTPYLYRILSPETIGQVEYS
                     TSIFGYFSLFGVLGIYNYGLREVSKNRDRQEKVKSIYANLFLIGCLSNFIVACIYLLFI
                     RLSFYSSPMYLL"
     CDS             complement(351..1163)
                     /locus_tag="ctg93_2"
                     /transl_table=11
                     /translation="MEDLNRYNKEGSDLRKLQYRMLELLEVLDKICKKHNLPYWLEGGT
                     LLGAVRHGGFIPWDDDLDVQMLRSDYKKLLKILPKELPGNIALQTFKTDKGYYRYVAKL
                     RDLNSKLISTSVDYKDCKFQGVFIDIIPMEFIKSKFLNKVSIYIRWKIVALKVKIPNDK
                     LGLKILLFNIIYFFENLMHFSFRLVDLFIRKNRELSYSYGIDFYEYSCPIEYIFPLSSI
                     TFENKVFWAPHDVDGMLRRNYGNNYMEIPPEDQREIQAHSLGVIFNEK"
     CDS             complement(1174..2277)
                     /NRPS_PKS="Domain: Aminotran_5 (30-298). E-value: 6.2e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg93_3_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     1.9e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_3"
                     /sec_met_domain="Aminotran_5 (E-value: 8.3e-31, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVKFVK"
     aSDomain        complement(1384..2187)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg93_3_Aminotran_5.1"
                     /evalue="6.20E-34"
                     /label="ctg93_3_Aminotran_5.1"
                     /locus_tag="ctg93_3"
                     /protein_end="298"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIKREWQS"
     CDS             complement(2274..3410)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.4e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(3422..4723)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_5"
                     /sec_met_domain="CTP_transf_like (E-value: 2.7e-12,
                     bitscore: 39.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 5e-64, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVCEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             complement(4743..5462)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.5; E-value:
                     3.8e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_6"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.7e-15, bitscore:
                     48.6, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTAMIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLS
                     CGIERIILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLL
                     ESDLVFERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKDALEAKG
                     ELVGIHKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEI
                     DDEADLSYAEEHIIRYC"
     CDS             complement(5455..6738)
                     /locus_tag="ctg93_7"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGSSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             complement(6745..7299)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg93_8"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 4.8e-72,
                     bitscore: 234.0, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEILKTTIEGLIIIEPKLFWDGRGYFFESFNQKEFEEKVCKIVFV
                     QDNESKSHYGVIRGLHFQKPPFAQSKLVRVIKGAVLDVAVDIRKGSPTFGKYFSVELTE
                     DNHRQFFIPRGFAHGFSVLSEEVIFQYKCDNFYHPEAEGAIVWNDTELKIDWKIPIEKI
                     TLSEKDKAYPNFMDQDFHFNY"
     CDS             complement(7310..8197)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 271; E-value:
                     1.9e-82)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg93_9"
                     /sec_met_domain="NTP_transf_3 (E-value: 8.4e-13, bitscore:
                     41.7, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLYPITKGISKQLLPIFDKPMIYYPISVLMLAG
                     IRKILIISTPYDLPGFQRLLGDGSDFGVHFLYAEQPSPDGLAQAFIIGEEFIGDDSVCL
                     VLGDNIFYGQSFTRMLQEAVRTVESENKATIFGYWVKDPERYGVAEFDNDGNVLSIEEK
                     PDTPKSNYAVVGLYFYPNRVVKVAKNITPSFRGELEITTVNQHFLLDQKLKVQLLGRGF
                     AWLDTGTHDSLSEASTFIEVIEKRQGLKIACLEGIALRQGWISSEKMKVLAQPMLKNQY
                     GQYLLKVIDELSVK"
     CDS             complement(8217..8690)
                     /locus_tag="ctg93_10"
                     /transl_table=11
                     /translation="MNQVQNLQHIARELLYLGMDGSPIYTDHFRQLNTEVFRLSEALFS
                     MKGTTSEEEAAICLSLLMGYNATIYNDGDKESKIQSILDRSFAVLDHLPASLLKCQLLT
                     YCYGEVFEEDLAQEAHQIMDSWKNRALSEEELEVMETLQTMEDNRYPCSEVED"
     CDS             complement(8710..9228)
                     /locus_tag="ctg93_11"
                     /transl_table=11
                     /translation="MSEQQEYWFAARTKKDQEFSVRNALEKLGIEYFLPTQFVIRQLKY
                     RRRRVEVPVIKNLIFVRTTKDRAWSITKDDHVPLYYMKDLYTHTLLIVPNKQMEDFKFV
                     MDLAPENVTFDDLPLTIGTKVQVVKGEFCGIEGELSSLANRTYVVIRIHGVLSASVKVP
                     KSYLRILSA"
     CDS             complement(10549..11553)
                     /locus_tag="ctg93_12"
                     /transl_table=11
                     /translation="MNLKFLYLLLLISALCISCSKDEEPSDKGSTSPQEPVYTTFTDAG
                     EVVVPGVLPANFTPRSVRVKGDTLFVANTNAADRSVLLLNLTTGELIGRIDSWVRKGVK
                     ETFNAEIGDMAVSDRYIFVGMYNSRINIFDRRTLQFVNAIGRSDGKWGDDIYSMTHCYG
                     LRECGERLMVRDKNTIRGYWIYEAVTEPAFRVPWIGKVKVSEGVGYDYQARIHGMAEYD
                     GRMYLTDWYNKSVQVFTPSKMEIVFGEETHITSDAVFKYDDIQPLGLLAYGGELLMSVQ
                     KSGKIQRYDPETGDLLGVLAEFPGKEIGRMEIARGMLYYIDLKAGKLMKAKGE"
     CDS             complement(11673..12686)
                     /locus_tag="ctg93_13"
                     /transl_table=11
                     /translation="MMKRHNILTVLAVLLLTFAACDKNSAPGFSFTTDSILTLTFDKEL
                     DAAFVGVGTQNYNPVGMRRSGDTLFIANRAEGSDGVWVVRASTGELLYSLTGWTYNGKN
                     EKFDNQVMDVAVSSDYIFVVNRSSRIDLFRRNDYSYVTTIGRTGWQSSSLLQCEAAEVA
                     GDKLFIRDKQKIKVVQISDCTPENRFKVPVFAQNTDSTSSNNGFNLESVARHEGLIYVS
                     DYETSRILVIDPATVAVKGEPVRFLRSYRMPNKPLSMGFFQNEMYVVCANNRIVRVDLR
                     TGKELGSYSSFAGGVGLGTPGRLFFHNDTFYLAGRNANAPRLIQGKVMFVEISELD"
ORIGIN
        1 gtaataaata cattggagaa gaataaaaag ataatcttat aaaaagtaaa tatatacacg
       61 ctactataaa attacttaaa caaccaatca ggaacaaatt ggcatagata gattttactt
      121 tttcttgtct atctctattt ttactaactt cacgtaaccc atagttataa ataccaagta
      181 ctccaaacaa actaaaatat ccaaaaatag aagtagaata ttctacttgc ccaattgtct
      241 ccggagatag tatacgatat aaataaggcg taaccaacag gggaagtact aaattaaaaa
      301 aattcaaagc ccctttatac agtgaatttt taaatataga atgaagcact ttatttttcg
      361 ttaaaaatga ctcctaaaga atgcgcctgt atctctctct gatcttcagg aggtatttcc
      421 atataattat tcccataatt ccttctcaac ataccatcaa catcatgagg agcccagaac
      481 actttattct caaacgttat agaacttaat ggaaaaatat actcaatagg acaactatat
      541 tcataaaaat caataccata agaatagcta agttctcgat tttttcgaat aaataaatct
      601 actagtctaa aagaaaaatg catcaaattt tcaaagaaat atataatatt aaataaaaga
      661 attttcaatc ccaatttatc attaggtatt ttcactttca atgcaacaat cttccatcgt
      721 atatatatag aaactttatt taaaaactta ctcttaataa attccattgg aataatatcg
      781 ataaatactc cttgaaattt acaatcctta taatctaccg atgtagaaat caatttagaa
      841 tttaaatctc ttagtttagc tacataacga taatatcctt tatccgtttt aaatgtctga
      901 agagcaatgt taccaggtaa ttctttgggc agtattttta ataatttttt ataatcagaa
      961 cgaagcattt gaacatctaa atcatcgtcc caaggaataa atcctccatg ccttactgca
     1021 cctaataagg tccctccctc tagccaatat ggaaggttat gctttttaca tatcttatct
     1081 aaaacttcca ataattccag catacggtat tgaagctttc ttaaatctga accctcttta
     1141 ttatatctat ttaagtcttc cattaataca aatttattta acaaatttca cagcttctct
     1201 catcacctca aagaacctct caatatcctc cacatcaatc tctcccaacg cacaaagccg
     1261 gaatgtattc gttgtggaaa tcttacccgg gtagatcgta aagccacgtt catagcagta
     1321 atcatgaacc ttatcaaaat cccagagggg atcatcagga tacaatacag aaacaacaag
     1381 acccgactgc cattcacgtt tgatcgcata ctgaagacca agctcttgca aacctttatg
     1441 gatggcttca aagaccctct tgtgacgggc gaatttagcc tcttcaccta ctgcaaaata
     1501 ttcatcaaga gcctgacggg cagcgtaaac ggtttgaaca ggaggagtaa aatgcatctc
     1561 gcccgtcttc tcaaagtaat cgtattgtaa atagaggtta caatagtagg aacgtttcgg
     1621 ataatccctt gaagcacgta tcagggattc atcacctatg ataaaggaaa gccccgtcat
     1681 ggcctgaagg cctttctgag ccgaagccat acaaaagtca acattatcct tcccgatatc
     1741 aaaaggaatc atacccaggg aggaagtggt gtcgacaaca aaaacggcac cgtgcgaatg
     1801 ggctattttt ccgatctcac ggatggggtt caagataccc gtacccgttt catggtgcgt
     1861 ggtatagacc aaagcgatgt ccggattgtc ggaaagcgtc ttttcgatta ccgacaggtc
     1921 gggaagttcg taaacggaaa acttcaaatc gatatgggga agaccgtaat attcgcagac
     1981 ttccaccgca cgggtgctgt aggcaccgtt attgacaacc agaactttct tatccgcagg
     2041 aagaagagag ttcaggcaga tatcgatatt gatcgtaccc gagccgcaaa acaggacggc
     2101 cgtatgtttg gagaggtctc catgcgcaac gcggaccagg tcgtcacgta actgtttcat
     2161 catacccgca aactctttct cacgcggaca gatatcggga acaacctgcg ccagcttcac
     2221 cgtatccgtc gtggtggcgg gacccggatt caaaaggatc tttctttcga tattcatgaa
     2281 tgcgtatctt ttaaaaatgc cataaaatgc tctttattct ctaccggagt agtcgtaggg
     2341 cgacccagat catcacgtga atcgatccgg accttaattt caagaagaac cgggccggac
     2401 aggccggaca gcttctcaag cgcacacgaa agcccttcct tgtcggaggc agtcagtaca
     2461 tgcgcataac cgcaaccttt cgctatcgag gcgatatcca gacggaaacc gagcgtgggt
     2521 tgaccgccga cagattcatg ggcaccgtta ttgaaaagga cgtgcctgta attcttggga
     2581 gaaagatcgc cgatattgct gacagcaccc atgtgcatga taaaggcacc gtcaccgtca
     2641 agacagtaga cacggcggtc aggcttctca agggcaatcc ccagggcaat ggaagaactg
     2701 tgacccatgg aacccacagt taggaaatcc cttgcgtgcc cctgcccttt cgattcacgg
     2761 tactcgaaaa gctcacggga gagcttgccc gtggtggaaa ccacaatgtc attgtccccg
     2821 aggtggtcga caacctgcat tagcgcctcc tcgcgggaca gaggatagtc attcaaggct
     2881 tcctgacgca atttatattt tccaaacgta tctttacgga tgacaatcgc atggggaatc
     2941 gaccggctct tcgccgagac aaccgcgtca tggatctgcg ccagggcctc gtcttcatcc
     3001 gtatccagaa ttataaaagg aattttcatg gctttcagaa gatcaagggt aacctcgccc
     3061 tgcttcttat gctggggttc gtctttcgtg ccgggctcac cgcgccaacc gaccagcaaa
     3121 agaagaggaa ggctgtacac tttctcgtcc gcaagggaca agaggggatt caccgtattt
     3181 cccagaccgg agttctgcat ataaaccaaa ggaacgttgc cagaagccat ataataaccg
     3241 caggcaatgc ccaccgcgga accttcattg gcggcgatga tatgcttacc acgcggagca
     3301 tgatccgtga tataggcgca aatattcttc aaaagggaat cgggaacacc cgtaaagaag
     3361 tcaacaccgt gatgaaggaa cgtatcgtat atcttttcta cacttaccat aaccgtctga
     3421 tttatttagt gcccggaatc aattccagaa tttccttgat aggcatacaa agcggacgga
     3481 cctcctcggc gcgctcgttt tcaaggatgg tcctggccac gttcatcatg gccggataag
     3541 cggcacggag aaggtggttg gcgtaaatga ctacgttggc accccattcg tgaagttcgg
     3601 attcgtgcac atggtcataa gtcgtcggaa caacgacaat gggaacatgg gcgtattctt
     3661 tgcggaaagt ccggcagaac tcacggatat cctcacccga cttatccttg ctgtggatca
     3721 tgatgccgtc cgcacccgcc tgtacatagg cataagcacg ttcgagggcg tcactcatgg
     3781 gtttgccggc aataaggctt tcgatacgcg caatgatcat aaagtcaccg gtgacctggg
     3841 cattcttccc tgctctgatc ttatcgcaga aaccctcgat actatcctga gtctggatag
     3901 cgtcagtacc aaaaagggaa ttcttcttca gaccaacttt atcttcaatg attaccgcag
     3961 aaatgccgtg acgttccaaa gtgcgcacag taaagacaaa gtgttcgatc ttgccacccg
     4021 tgtctccatc aaaaataata ggcttggtgg tgcattcaag gatattgttc aggtcctgta
     4081 aacgggtggt aaggtcgacc gcttcaatat ccggtttacc cttactcgtg gagtcggtca
     4141 ggctgctgga ccacatgccg tcaaagacct cgcgcttatc acccttctgg acttcaagat
     4201 tctcaataat cagaccgcaa agaccgtcgt gagcctccag gatacggacc acaggcttgg
     4261 cctggatcag gcggcggagg gacttaagac gtacgtcagg ggtagtcccg atcgccttga
     4321 tatccttgtc gagcgaggag gagttgatgc cccgggtata agggatctcg attaccttgc
     4381 ccccctgggc gttcatcacc tcaaaaacct gttcgcgcac ctcgcgcaac gggcccgttt
     4441 tccagtcgtc gccgtggatg atatagtcag gcttgagttt ttccagattc ggaacatagc
     4501 tccaatcctc ctggggaaca acttcgcaaa cccctttgat attctcaaca acctccttac
     4561 gctgatcata ggtaaggtaa gggaggcgtt tgtgttcggc gatggccttg tccgtcagca
     4621 gaccgacgat gacatcaccg tatttagtag cttcatgaat aatatggatc aaccccggat
     4681 gcatgatatc cgcggtcata ccgacataga ttttcttgtt catatatgga aaagatttgt
     4741 ttttaacaat agcggatgat gtgctcctca gcatacgaaa ggtcggcttc atcatcgatt
     4801 tcataccatt taagaccctc caccctgagc acacggacag gggaaacgga acgggacatg
     4861 cggagcagtt cgtactcgta acccagttta ggctgggact ccaggatggt cgcataatcg
     4921 gcgcacatcc ggcggtagaa agtattggaa agtttatgga taccgaccag ctcgcctttt
     4981 gcctcaaggg cgtccttgtc taccgaacag gaagtaagga tgtgattgcg gtcatattcc
     5041 acataatact gatcctggaa cttggtcaga gaagagacaa gcatcacatc cgggaattcg
     5101 tcatccagca gcgagaggat ggccttgcgt tcaaaaacaa ggtccgattc aagcagcagg
     5161 aaactgtcat cgcctatcac gtcacgcgta ttgtacagag tgtacatact gttagtatcg
     5221 gcataacggg gactgaaaca ggtctctatc tgggggaaat ccgcctgaag ggcttcataa
     5281 gcctcttttt tataacccgt accgaggatg atacgttcga taccgcagga aagaagggtt
     5341 tcgatagagc ggataatcat aggttttcca ccaacctcca caaaaccttt gggcacaagc
     5401 tcggtataat gcccgaagcg ggtaccaaga ccggcagcca tgatcattgc tgttttaatc
     5461 atgaatttca gagggaatta atataagtga attcaattgt tgcttgaaat aacagtaaat
     5521 cgcaaaaatc gacaggacag aaacaaatcc tgaaaaaagg gcagtacgca tcagcatgac
     5581 agtccaggaa atgtcagcag aaacgaagtt cttgaccata aacacacccg tagtgcccag
     5641 atagccgaaa gaatcggcca aataaataat aaaaacagcc gtactaacca ccctaaggga
     5701 agcaatcaga cgttctatca ggtaagtgaa aggaatatac cccatataca gaccaagacc
     5761 ggaaagaatc atccaccaaa taggagaaag aaaaccgtac acataaagca atgtggaaaa
     5821 aaccattaag gaactgcctg tgacggcgat gcaataaatg atattaagag ccaaacggtt
     5881 attacggaca aacacaatca ggaacatcag tacaaggaca aaaacggcaa tgggaacctc
     5941 tgtctgagta aagatcattg caccctcaat atggagctcc ttccaaatat cggcagcgaa
     6001 agagtcacga agctcacgga acacggtcag ggcaccgtaa aaaacaacca gcatgcagat
     6061 tccccaaaag aattgcctca aaaatttacg cctgtcttta ccatccatcg gagcacgttt
     6121 ggtacgctgt atgatatctt gctcattggg agccggaatc tgattgagaa gccagctgca
     6181 aagcaacata acagggtata ccaacaaacc ggtggtaaaa ggcatccaat attccgacac
     6241 atgcaaatta tccatcacga attgtcccaa ggttttcacc aaaccggaag agactatcaa
     6301 agcaacgctc agcccgacat tcaatatttc actgatacga cgtccttcga tatagctaaa
     6361 aatgacaccc cagatcatac ccaggggaag accgctcaga aaaatagaac acaccttcaa
     6421 aggaaccgga agaagtgcaa aacccaacaa agcaacttcg gaaaaagtaa gcagccctat
     6481 tatataatag atgcggtgac ccgctttcat cgaaggcaga atacgaacac cgatgaactt
     6541 ggaaagggcg tagccgataa tctcagaaag gacatacagg attttgacat cgaatcccca
     6601 aagaatctca ccttcataaa tggctgcggt aaatggctta cggtaggcat aggcacaagt
     6661 ataaaccaga aaaatcaaaa cgctggcata gagagccaaa acgtaaaggg gagaacggga
     6721 aagaaaggaa cgaatcatta tcttctagta attaaaatga aagtcttgat ccatgaaatt
     6781 aggatatgct ttatcctttt cgctcaatgt aattttttca attggtatct tccaatcaat
     6841 cttcaattct gtatcattcc aaacaatcgc cccttccgct tccggatgat aaaaattatc
     6901 acatttatat tgaaaaatga cctcttcact taatacacta aagccatgag cgaatcctct
     6961 tggaataaaa aactgacgat gattatcttc tgttagttct actgaaaaat atttcccaaa
     7021 tgtcggtgaa cctttacgaa tatcaactgc aacatcaaga acagcccctt taataactct
     7081 aactaattta ctctgagcaa aaggaggttt ctggaaatga agaccgcgta taacgccata
     7141 gtgagacttg gattcgttat cttgaacaaa cacaatctta catactttct cttcaaattc
     7201 tttttgatta aaagattcaa agaaatagcc ccgaccgtcc caaaaaagtt taggctcaat
     7261 aataataagt ccttctattg tcgttttcaa tatttccata aaaagacatt tactttactg
     7321 ataattcatc aataactttc aataaatatt ggccatattg atttttcaac attggctgtg
     7381 ctaatacttt catcttctcc gaagaaatcc atccttgcct cagtgcaatc ccttccaaac
     7441 aagcgatttt taaaccttga cgtttctcga tcacttcaat aaaggtactt gcttcagata
     7501 aagagtcgtg cgtacccgta tctaaccaag caaaaccacg gcctaataat tgaaccttta
     7561 gtttttgatc caaaagaaaa tgttgattaa cagttgttat ttctaattct cctcggaaag
     7621 aaggagttat attttttgcc actttaacaa ctctatttgg ataaaaataa agtcctacaa
     7681 cggcataatt agatttaggt gtatcaggtt tttcttctat actaagtaca ttgccatcat
     7741 tgtcaaactc tgctacaccg taacgttcgg gatccttcac ccaataaccg aaaatggttg
     7801 ctttattttc tgactctact gtacggactg cctcttgtaa catacgagta aaactctgcc
     7861 cataaaaaat attatctcct aaaaccaaac atactgagtc atctcctata aattcttcac
     7921 caataataaa agcctgcgcc aagccatcag gagaaggttg ctcagcataa aggaaatgaa
     7981 ccccaaagtc agagccgtca cctaataaac gttgaaatcc tggcaaatca tacggagtag
     8041 aaataattaa tattttccga attcctgcta acataagaac tgaaatagga taataaatca
     8101 tcggtttatc aaaaatagga agcaactgct tgcttattcc tttagtaata ggatataaac
     8161 gtgttcctga accacccgcc aaaacaatac ctttcatttt tttatatgtt attttatcaa
     8221 tcttctacct cactacacgg ataccgatta tcttccattg tctgcaatgt ctccatcact
     8281 tccaattctt cttctgaaag tgccctattt ttccagctat ccattatttg atgtgcttct
     8341 tgtgctaaat cctcctcgaa tacctcgcca tagcaataag tcagcaattg gcatttcaat
     8401 agagaagcag gaagatggtc caatacggca aaagagcgat ctaaaatgct ttgtatctta
     8461 gattctttgt cgccatcatt gtaaatggta gcattatagc ccattaacag ggacagacaa
     8521 atcgctgctt cttcctcgga tgtggtacct ttcatagaga aaagggcttc ggacaagcga
     8581 aaaacttcgg tgttcagttg acggaaatga tcggtataga tgggagaacc atccataccc
     8641 aaataaagca actcacgggc aatgtgttgc agattttgga cttgattcat ataattttga
     8701 aattacgaat tacgctgaaa gaatacgaag gtaactttta ggtactttga cgctggcaga
     8761 aagaactccg tggatacgaa tcactacgta agtacggttg gcaaggctgg acaattcgcc
     8821 ctcaatgcca caaaattctc ctttgacgac ctgcactttt gtaccaatgg taaggggaag
     8881 atcatcaaaa gttacatttt ccggagctaa atccatcaca aacttgaaat cttccatctg
     8941 tttgttggga acgatcaaca aagtatgggt atagagatcc ttcatataat aaagaggaac
     9001 atgatcatcc ttcgtgatag accaggcacg gtctttcgtg gtccggacaa aaataagatt
     9061 cttgataaca ggaacttcta ccctacgacg acgatatttc agttgacgga tgacaaattg
     9121 tgttggaaga aagtattcta ttccaagctt ttctaaagca ttgcgaacag aaaactcctg
     9181 atccttcttt gtccgagcgg caaaccaata ctcctgttgt tcagacattt attagtggat
     9241 attaaaagtc gagaggttac tttcgggtgc gctacgcggt ttggacgaga catcttttcc
     9301 cattcaaacc gtaagaattt ccgaaactat ttttagtggt aaaacgaatg aaattgtttc
     9361 aaaaaacgtt cgtcttttgg aacacctttt ttcgaccttt tctaaaaatc atgttcttat
     9421 agaaaaaaca catatataaa gattctattt catgtatata atactcttat aatcagtata
     9481 ctaaaataga taaagaaaga aaaactcaat ttatttataa aaatattttg ttgttataaa
     9541 aatgtgcctt acctttgtgt ttataaacga acgttttttg aaacacccct ccccttttct
     9601 tccatctact ttatattacg tatctgtttg tagtccaata ggtaagtacc ctagcctcct
     9661 atcatttaca caaaaaaatt tctccttacg cgcgagacga cacctacttt agaaaacagg
     9721 ttcttcgtca agtttggtgg taagttttct tttactcatg gaatctaatt cagttttcgg
     9781 aagtgcaagc cctcgtttat agttgacaaa aaagcaagta tcccggcttt cgcccgaagt
     9841 gtccattcgt gaggtgaaga agcgaatctt agactaaact atctgaaaat caacatcttt
     9901 aaaaagtaag atttctgtct tcaaaagctt tgttttaaca caaagttaaa gcttgttctt
     9961 tggatataaa taagaagttc tttaaatgca aaagacttgt tatttgcgca caagaacctg
    10021 acaacctgta aaaggcgtta acaatgttaa ttgaagaaaa gtataaggat gaagataccg
    10081 gttcagacgg cataaattca cttccaaaac ttgagttatc ttattcagcc ggtgtctgtt
    10141 ttttcttatt aaagcaagca aaaaggacaa ttatcaactt ggagataaag aatttaccac
    10201 caaatttgat ttaaataggc tataaatagt aatatggaaa aagtgaaaat cggagaaaac
    10261 tccagaaaag tatgacgaat acttatacat gcaagaaaag tctctgtgaa agaactttgc
    10321 agcttgacct gcctgaatat agacgatgta atgcttgctg tcggatggtt ggcaaaagag
    10381 aacagttctt tttatcgaaa agaaagcaga ttctttttat gtcagcgacg gttctgagta
    10441 ttacttctgc ttcggatagg acatgcagat gaaagaacga gggtgtgtcg aaactcgtat
    10501 tcaccacaga ttgctctgtg gtgagtcatg acacactctc gccgttcttt attctccttt
    10561 tgccttcatc agtttcccgg ctttgaggtc aatgtagtaa agcattcccc gggctatctc
    10621 catgcgcccg atctccttac ccggaaactc ggccagcact ccgagcaggt ctcctgtctc
    10681 cggatcataa cgctgtattt tcccactctt ttgtaccgac atcagtaatt cgcctccgta
    10741 ggcaagcagt ccgagcggtt gaatatcatc gtacttaaac acggcatcgg aagtgatatg
    10801 tgtctcttca ccgaacacga tctccatttt cgacggagtg aacacttgca cactcttgtt
    10861 gtaccagtcg gtcagataca tacgcccgtc atactctgcc ataccatgga tacgggcctg
    10921 atagtcatat ccgactcctt cggacacttt cacctttccg atccagggaa cccggaacgc
    10981 aggttcggta acggcttcgt aaatccaata gccgcgaatg gtatttttat cacgcaccat
    11041 cagtctctcg ccacactcac gaagtccgta gcaatgggtc atgctataaa tatcgtctcc
    11101 ccactttccg tctgaacgcc cgatggcatt gacaaactga agggtgcgac ggtcaaaaat
    11161 attaatacgg gagttgtaca tacccacaaa gatataacgg tcagaaacag ccatgtcgcc
    11221 tatctcggca ttaaaggtct ctttgacacc tttccgtacc catgaatcga tacgtccgat
    11281 cagttcgcct gtcgtcaggt tcagcaacag cacggaacgg tcggcggcat tggtattggc
    11341 aacaaacaaa gtgtccccct tgacccgtac ggaccgggga gtgaaattgg ccggaagcac
    11401 tccgggaaca accacttcgc cggcatctgt aaaggtggtg taaaccggct cttggggaga
    11461 agtactgccc ttatccgaag gttcttcgtc cttggaacag gatatacaca gggcagatat
    11521 caataataac agatataaaa atttcaaatt catgcttgat tgttttctca ccacagacga
    11581 cacagaaagt tttcttctct taaaccgtca tccggatata gaggagtgta caaacctgca
    11641 taatctgcag cgaatcgtaa ttattcattt ttttagtcca gctcggatat ttcaacaaac
    11701 ataactttcc cctgtatcag ccggggagca ttggcattgc gccctgcaag atagaatgta
    11761 tcattatgga aaaagaggcg tccgggagtt cccagcccca ctcctccggc aaaggatgaa
    11821 taagagccga gctctttccc ggtacggagg tctactctca cgatgcggtt atttgcgcag
    11881 acaacataca tttcgttctg aaagaatccc atactgagcg gtttgttcgg catgcggtaa
    11941 gagcgcaaaa agcgtaccgg ctctcccttg accgccacgg tggcgggatc gatcaccagg
    12001 atgcgtgagg tttcgtagtc ggacacatag atcaagcctt catgccgcgc aacggactca
    12061 agattaaaac cgttattaga agacgtactg tccgtattct gagcaaagac aggaacctta
    12121 aaacgatttt caggcgtaca atctgaaatc tgcaccactt taatcttctg tttgtcacgg
    12181 atgaacaatt tatcaccagc cacttcggcc gcttcgcatt gcaacagaga actcgactgc
    12241 catccggtac gcccgatggt ggtcacatac gaataatcgt tccgtcggaa caggtcgatc
    12301 cgggacgaac ggttcaccac aaagatgtaa tcgctgctga ccgccacatc catcacctga
    12361 ttgtcgaact tctcgttttt cccgttgtag gtccagccgg tcagcgaata aagcaactcc
    12421 ccggtcgaag cgcgtaccac ccacacaccg tcagaacctt cggcacggtt ggcaatgaaa
    12481 agagtatcgc ccgaacgccg cattcccacc ggattgtaat tttgggtccc cactccgaca
    12541 aaggcggcat ccagctcttt atcgaaagtc aatgtaagga tggagtcagt cgtgaaactg
    12601 aatccggggg cactattttt atcgcatgcg gcaaaggtga gcagcaggac tgccagtacc
    12661 gtcagtatgt tatgtctctt catcatagct ctatgtcggg attgtcggca tcattgatgc
    12721 cgggattata atcattgtaa ctcttaaagg gattgatgat ataaggcagc atgcggtgct
    12781 tcatcatgta gcgatacact ttcggtacta tttcatcggg caccgacccg taacacaggc
    12841 tgctagaatg accatagccc agacagtgcc ctagctcgtg aatccagaca tgaagcaccc
    12901 agttgcaatc gattgccacc cggttctggt agaagaatcc ggccagatat tcttcacgca
    12961 atcccaaagc atttcctcca ccgagcccgg cgataccgga accggtaacc actccgaaca
    13021 caagactttg tttattgaga attgaattca gtagcccttc acggtcgatc tcctttcctg
    13081 catcattgtg aatgctacct ttgtagttca tcaatgaatc acgaaaaatt tcggaactga
    13141 acatgacagc catattcacc gccgatgtgg catagtagcg ggctgcattt gctgtca
//
