LOCUS       c00468_gnlPro..        15657 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JIEFPDNF_468.
ACCESSION   c00468_gnlPro..
VERSION     c00468_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 10:17:25
            Original ID  :: gnl|Prokka|JIEFPDNF_468
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1468
            Orig. end    :: 17125
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15657
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11468:16604]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15136
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..15657
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15657
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             1228..2397
                     /locus_tag="ctg468_3"
                     /transl_table=11
                     /translation="MEKVIYNLVFNRKKRLNAEGKALIQVEAYLNRQKKYFSTKIYVKP
                     TQWDSKRKAVKNHPNMDELNQYIEDYITYLERIELDMVQSGRPFSLKYLRERGDFESVS
                     SSFVSFMKNEINHSNLRLSTLKNHLSTLQVLCQYQPQVSFDDLTFNFLCGFEHFLLEQK
                     YHRNTIAKHMKHLKRYVNLAINKDLFELQKYPFRKYKIKYMESKRGHLTPEELGRLENI
                     APKLQRTLRRTLDMFLFSCYTGLRFSDIVNIRPDNFHLIDDKLWLVYSSVKTDVNVRLP
                     LFLLFDGKALVVYERYCKRYSRTLFGVSVSANSNVNKQLKRICRLAEIDKRLSFHMARH
                     TNATLLLYNGANITTVQKLLGHKSVRTTEIYSDIMDMTVIRDLENITLK"
     CDS             2645..3925
                     /locus_tag="ctg468_4"
                     /transl_table=11
                     /translation="MMSQPLAERLRPKTLDDYIGQKHLVGPGAVLRKMIDAGRVPSFIL
                     WGPPGVGKTTLAQIISNKLEAPFYTLSAISSGVKDVREVIEKAKGNRFFNTVSPILFID
                     EIHRFSKSQQDSLLNAVETGVVTLIGATTENPSFEVIRPLLSRCQVYVLKSLEKADLLT
                     LLNKAVTEDIILKDMNIVLAETDAMLRYSGGDARKLLNILELVVAAEEGNEKIEITDEK
                     VVERLQENPAAYDKGGEMHYDIISAFIKSIRGSDPDAAVYWLARMVAGGEDPEFIARRL
                     VISASEDIGLANPNALLLANACFDALKKIGWPEGRIILAETTVYLACSPKSNSAYMAIN
                     DALELVNRTGNLPVPLHLRNAPTKLMAELNYGKDYKYAHDYENHFVKQEFLPKEILNER
                     LWKGQENPSEHKLIEQMRRLWGDRYQN"
     CDS             4108..5175
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg468_5"
                     /sec_met_domain="Aminotran_5 (E-value: 2.2e-43, bitscore:
                     138.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKHNFYAGPSILSEYTIKNTAAAVENFAGMGLSLLEISHRSKEF
                     VAVNDEARALIKELLDVPAGYEVVFLGGGASMQFCMVPYNLLNKKASYLDTGTWSSKAI
                     KEAKLFGEVEVVASSKDKNYTYIPKDYTIADDADYFHITTNNTIYGTETRKDPDVKQRL
                     VADMSSDIFSRPIDVSKYDIIYAGAQKNLAPAGVTLAIVRVDALGHVERPIPTMLNYKT
                     HVDKDSMFNTPPVLPIYAALQTLKWYKEQGGVAAMEKKDMENAAILYDEIDRNKLFRGT
                     VAAEDRSIMNVCFVMNDEYKELEDEFSKFAAAAGMVGIKGHRSVGGFRASLYNAMPKSS
                     VEALVACMKDFEKQH"
     CDS             5178..6101
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg468_6"
                     /sec_met_domain="Hacid_dh_C (E-value: 8e-36, bitscore:
                     113.1, seeds: 144, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKILVATDKPFAAIAVKGIREVVEGAGDELILLEKYGEKAKLLE
                     AVKDVDAIIIRSDVIDAEVLDAAKQLKIVVRAGAGYDNVDLAAATAHNVCVMNTPGQNS
                     NAVAELAFGMMVMAVRNFYNGTSGTELKGKKLGIHAYGNVGRNVARIAKGFGMEIYAFD
                     AFCPASAIEADGVKPVASPEELYATCDIVSLHIPATAETKNSINYALVGKMPKGGLLVN
                     TARKEVINEAGLIKLMEERTDLKYVTDIMPVANEEFATKFAGRYFSTPKKMGAQTAEAN
                     INAGIAAAKQIESFLKEGCEKFRVNK"
     CDS             6118..7365
                     /locus_tag="ctg468_7"
                     /transl_table=11
                     /translation="MARIKPFKGIRPPKDLIEQVASRPYDVLNSEEAREEAKGNEKSLY
                     HIIKPEIDFPVGTDEHDPAVYLKAAANFRMFQEKGWLVQDKEECYYVYAQTMNGKTQYG
                     LVVGAYVPDYMNGVIKKHELTRRDKEEDRMKHVRVNNANIEPVFFAYPDNAELDQIVAK
                     YTSRNPEYDFVAKDDGFGHTFWIIDEPADIARITELFGEMPSLYIADGHHRSAAAALVG
                     AEKARQNAAHKGDEEYNYFMAVCFPANQLTIIDYNRVVKDLNGLSEEEFLAKLEKNFVV
                     EEKGADIYKPAALHNFSLYLAGKWYSLTAKQGTYNDNDPIGVLDVTISSNLILDEILGI
                     KDLRSDKRIDFVGGIRGLGELQRRVDSGEMKVALALYPVTMKQLMDIADTGNIMPPKTT
                     WFEPKLRSGLVIHKLE"
     CDS             7526..8152
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg468_8"
                     /sec_met_domain="HAD_2 (E-value: 2.4e-10, bitscore: 30.9,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIRNIVFDLGGVLIDLDHHQAVSRFEEIGVKDAKQLLDPYEQK
                     GFFLELENGKIDVDTFCRKLCEHTGKQLSYDEIKYAWMGFIADVPQYKLDFLLELRKKY
                     KVYLLSNTNPIVQSWARSEAFTPAGRPISAYFDKMYTSYEVGVTKPDAAIFDRMIENAP
                     LIPAETLFVDDAKSNIEVGQGLGFHTYQPENGEDWREAVLNILAK"
     CDS             complement(8832..9872)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg468_9"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 5.7e-49, bitscore:
                     157.3, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQKILVAGGTGYIGSHTTVELQNAGYEVVIIDDLSNSNIEVLDG
                     IERITGIRPEFIKLDLKDKEGTREALKAHPGIKGIILFAASKAVGESVQQPLKYYRNNV
                     VTLVNLLELMPEFNIEGIVFSSSCTVYGQPDPENLPVTENAPIKPATSPYGNTKQINEE
                     IIRDTIHAGAPFKSIILRYFNPIGAHPTAEIGELPNGVPQNLIPYLTQTAMGIRKELSV
                     FGDDYDTPDGSCIRDYINVVDLAKAHVIAMDRMLGGKSLDNVEIFNLGTGNGVSVLELI
                     NTFEAATGVKVPHKIVGRREGDIEKVWANPERANKVLGWKATETLADTLASAWKWQERL
                     RERGIM"
     CDS             complement(10001..10573)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg468_10"
                     /sec_met_domain="Rnf-Nqr (E-value: 2.4e-64, bitscore:
                     206.6, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYILIFIAAVFVNNVVLSQFLGICPFLGVSKKVDTAIGMGAAVA
                     FVLTIATLVTFLVQKYVLDVFGLGFMQTISFILIIAALVQMVEIILKKVSPALYQALGV
                     FLPLITTNCCVLGVAIQVIQKQYNLLESVVYAFSIAIGFALALIIFAGVREQLAMTNVP
                     DGMKGTPIALITAGLLAMAFMGFSGIV"
     CDS             complement(10587..11171)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg468_11"
                     /sec_met_domain="Rnf-Nqr (E-value: 5.6e-69, bitscore:
                     221.7, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNLKILMNGIITENPTFVLLLGMCPTLGTTSSAMNGMSMGLATM
                     FVLICSNMVISALKNVIPDMVRIPGYIVVIATFVTVVQMCMEAFIPALYASLGLFIPLI
                     VVNCIVLGRAEAFAAKNGVVASAFDGIGIGLGFTIALTLLGAIRELLGTGKLFNLTIMP
                     EQFGSLIFVLAPGAFIALGFLIAIVNKLRKA"
     CDS             complement(11164..11778)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg468_12"
                     /sec_met_domain="FMN_bind (E-value: 5.9e-24, bitscore:
                     74.7, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFLSLTIICVVAGAILAGVNMYTTGPIAATKAAALEAAIKAVTPA
                     FDNKPTEEAYMAVTADGDSLKIYPAKQDGKFVGAAVESNTMKGFGGEIRVIVGFDTEGK
                     LLNYSVLQHAETPGLGAKMQEWFRTDKNRQSVLGRNLSDGELKVTKDGGDVDAITASTI
                     TSRAFLNAVNRAYSAFSGADGLTGATTSSDNTTKEGGNDNE"
     CDS             complement(11811..12770)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg468_13"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 1.9e-116,
                     bitscore: 378.6, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLYVSPSPHIHGGDSISKNMYGVLIALVPAFLVSLYFFGLGA
                     LIVTVASVFFCVLFEYLIQKFLMKKEPTIYDGSAILTGVLLAFNLPSNLPIWIIAIGAL
                     AAIGIGKMSFGGLGNNIFNPALTGRIFLLISFPAQMTTWPVVGQLTSYADATTGATVLS
                     LMNEGALDKMPTLSDMLIGNMGGSLGEVSALALLLGMFYMLWKKIITWHVPVSIFVTVF
                     VFTGIMHLVNPVQYASPFVHLLSGGLMLGAIFMATDYVTSPMSKSGMIVYGVGIGILTT
                     VIRLFGSYPEGMSFAIFIMNGVTPLINSYMKPKHFGGK"
     CDS             complement(12783..14114)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: RnfC_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg468_14"
                     /sec_met_domain="Fer4_9 (E-value: 1.9e-09, bitscore: 27.8,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="SLBB (E-value: 1.7e-16, bitscore: 50.0,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 5.1e-50, bitscore:
                     159.4, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 5.7e-32, bitscore: 99.9,
                     seeds: 53, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.5e-05, bitscore: 15.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRTFRIGGIHPPENKLSAGKKITALAAPKQVIIPLSQHIGAPAQ
                     AVVKKGDLVKVGTLVAKAGGFVSANIHSSVSGKVNKIDNALDSSGYKRPAIYIDVEGDE
                     WEETIDRSDALVKDCTLSSKEIVDKIAAAGIVGLGGATFPTQVKLMPPPGSKAEIIIIN
                     AVECEPYLTSDHSLMMEKGEQILVGVTLLMKAVNVNKAVIGIENNKPDAIAHLTKLAAA
                     YPGIEIMPLKVQYPQGGEKQLIDAVIRRQVKSGALPISAGAVVQNVGTAYAVYEAVQKN
                     KPLFERVVTVTGKAVANPSNFLVRMGTPINTLIEAAGGIPENTGKIIGGGPMMGKALVS
                     AEVPVTKGSSGVLLLTKEESVRKPMQDCIRCAKCVNVCPMGLNPAFLMKFTIYKDWEKA
                     EGGYIQDCIECGSCSYTCPAHRPLLDQIRLGKGKVMGIIRARKS"
     CDS             complement(14126..15136)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 36.2; E-value:
                     2.3e-11)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg468_15"
                     /sec_met_domain="Fer4_7 (E-value: 6.1e-12, bitscore: 36.2,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.1e-11, bitscore: 34.3,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 1.5e-09, bitscore: 27.8,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 3.5e-11, bitscore: 32.8,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.3e-06, bitscore: 18.9,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILIAVISLGAIGAIGAVFLYAASKKFEVYEDPRIAQVQEVLPGA
                     NCGGCGYPGCGGFATACVKADTLDGLLCPVGGAPVMGKVATILGKEAASAEPMVAVVRC
                     NGTCAARPRTNQYDGVQSCAIASTLYGGETGCSFGCLGYGDCVAACNFDAIHINLETGL
                     PEVDEDKCTSCGACVKACPKNIIELRKKGPKSRRVFVSCVNKDKGGVAKKACANACIGC
                     GKCAKECPFEAITVENNVAYIDYTKCRLCRKCVAVCPTGAIHELNFPPRKEAAPAVDAD
                     KIKPATAPKPAAPKADAPKTEVPKKESPKAEAPTANATPNAATPKVETKEETIQK"
     CDS             complement(15147..15596)
                     /locus_tag="ctg468_16"
                     /transl_table=11
                     /translation="LPRFCNVEITNMSESINHNGIIEKIDGGTVYVRIIQQSACSGCHA
                     KSMCTASESKEKIIEVPDNSGKFHINEEVQLCGQSSLGLQAVLLAFVFPLIIVFAAIVT
                     GTSMQWEETTSGLTGLLLLVPYYCILYFLRDKLKKRFIFTLKKLN"
ORIGIN
        1 aagaaatgca gaacaatccg cgtgctactg tccagcaggt atatgatcag attatgagcg
       61 atttgaatca ggcagcagaa ttgttggccg gctttgataa tggagcgaat aaagaccaat
      121 tggatgaagc ggtcgtatat ggcttgcgtg cccgtgccaa tctgttgatg cagaaatggg
      181 ctgatgcagc aaaagatgca gaaagagcta ttgccggcgg aacaccgcaa tcattggcag
      241 aagtatctac tccgacattt aattctgcta ctgcaaattc ttggttatgg ggtgtcatga
      301 tcactccgga taatgatgtt gtacaaaccg gtatcataaa ctggccttct catttgtgtt
      361 cttttacggg gaacggatat acttcaggtg ttcctgacgg atacagaaaa gtgaatacgg
      421 atttatatga ccagattccg gatactgata ttcgtaaaca atggtttttg tctccggata
      481 gcacatcttc gttgatagac aatgaaacga tagaaggatc ttctattgtt gagtatttcg
      541 gtcttgaacc atatgtaaat actaagttcg gtgcttatca gagtgtgttt gggaacacga
      601 ctaatgcttc ggattggccg ttgatgcgtg tggaagaaat gtatttgatt aaagcggaag
      661 ctgaagcaat gagtggaaat ctggcggcag gtaaatctac attggaaaac ttcgtgcaag
      721 cctatcgcga cccttctttt gttagtaaag ctacttcgcc acagcaattt caagatgaag
      781 tctggctgca gcgtcgtatg gaactttggg gcgaaggtca ttcgttgttc gaccttttac
      841 gcttaaagaa gccggttata cgtaaaaata cgaattatca tgcttccgta cagtttaatt
      901 tggagccgga atcccagata atgatctacc gtattccgca atgtgaaatg gagaccaata
      961 caggtatttc tgatgcagat aataatccgg cggctccaca acctgcttta taaaagaaat
     1021 aaggtttata tccggaaaag gaatgaagag gcgtgttcaa aaaacacgcc tctttttttg
     1081 tctctgtccg ggcttttgca ggatagcttt gctgatagtt gttcttctat tgaaacacga
     1141 aatataacaa acttttagtt tgtctcatac gaaacaaaga acttattatt gttccttcgt
     1201 gttctcattc agaaaataat gtatatcatg gaaaaagtta tttacaatct ggtgttcaat
     1261 cggaaaaagc ggttgaatgc agaaggaaag gctttgattc aggtagaggc ttacctgaat
     1321 aggcaaaaga agtatttctc aacgaaaatc tatgttaagc ccacacaatg ggatagcaag
     1381 agaaaagctg tgaagaacca tcccaatatg gatgaactca atcagtacat tgaggattat
     1441 attacttatt tggaacggat cgaattagat atggtccaaa gcggacgtcc gttttctttg
     1501 aagtatttga gggaaagggg agattttgaa tccgtctctt cctcttttgt ctcttttatg
     1561 aaaaatgaga tcaatcatag taacttaaga ctttccacat tgaagaacca tttatccact
     1621 ttgcaggttt tgtgccagta tcagccacaa gtctcttttg atgatcttac ctttaatttc
     1681 ctttgtggtt ttgaacattt tcttcttgag caaaagtacc accggaatac gattgccaag
     1741 catatgaagc atctgaaaag atatgtcaac ctggcgatta ataaggattt gtttgaattg
     1801 cagaaatatc cttttcgtaa gtataagatt aaatatatgg agagcaagcg tggtcatctg
     1861 acacctgagg aattggggag gttggagaat atcgctccta aattgcaacg aacgctcaga
     1921 cggacgctcg atatgttcct tttcagctgc tataccgggc tgcgcttttc cgatattgtc
     1981 aatatacgac cggataattt tcatctgatc gatgataagt tatggctggt ctattcatcg
     2041 gtcaagacgg atgtgaacgt ccggcttcct ttgtttctgc tattcgacgg aaaagctctt
     2101 gttgtttatg aacgctattg caagcgttat tcaagaacgt tgtttggagt ttctgtttcg
     2161 gcaaactcga atgtgaataa acagttgaaa aggatttgcc ggctggcgga aatagataaa
     2221 aggttgtctt tccacatggc acgccatacc aacgctacct tattattata taatggagcg
     2281 aatatcacga cagtccagaa gttgctgggg cataaaagtg tacggacaac ggaaatctac
     2341 agtgatatta tggatatgac tgttatacgt gatctggaaa atatcacatt gaaataaaat
     2401 aaggtaatag atacgggggg cagtgcattc tctgatacac actgccctga tctttcatga
     2461 ttttattcag tgcccaagag ttgtaaatat gacaaaatgt tatctcatta tggtttttat
     2521 aggcgtgtgc tgccgtgtgt gcttactttt tatcatattt tctgttgtca aacattaaaa
     2581 tagccttgaa tttttactgt atttatactt tgaaaagtaa ataaaatatg cgacttttgt
     2641 tggcatgatg agtcaaccgt tagcagagag attacgtccg aaaacgttgg acgattatat
     2701 cgggcagaaa cacctggttg gtccgggggc tgtccttaga aagatgattg atgcgggtcg
     2761 tgtcccctct tttatattgt ggggacctcc gggagtagga aagactacgc tggcgcagat
     2821 tatttcgaat aagctggaag ctccgttcta cacgttgagc gcaatcagtt caggagtgaa
     2881 agatgtgcgg gaagtgatag aaaaggcaaa aggcaatcgc tttttcaata ccgtttcacc
     2941 gatcctgttt attgacgaaa tacatcgctt tagcaagtcg cagcaggatt ccctgcttaa
     3001 tgctgtagag acaggtgtgg taaccttgat cggagccacg acagagaatc cctcgttcga
     3061 ggtcatccgt ccgttgcttt cccgctgcca ggtatatgtt ttgaaatcat tggagaaagc
     3121 tgatctgttg accttgttga ataaggcggt taccgaagat atcatattga aggatatgaa
     3181 tatcgtgctg gccgagacgg acgccatgtt gcgttattcc ggtggcgatg cgcggaaact
     3241 gctgaatatc ctggagcttg tcgttgctgc ggaagaagga aatgaaaaga ttgaaataac
     3301 agatgaaaag gtggtggagc gcttgcagga aaatccggcg gcgtacgata aaggagggga
     3361 gatgcattat gacatcatat ccgcttttat caaatccatt cgcggaagtg atccggatgc
     3421 cgctgtctat tggctggctc gtatggttgc cggtggcgaa gatccggaat ttatagcccg
     3481 ccgtctggtt atttcagcat cggaagatat cggattagcg aatccgaatg ctctgttgtt
     3541 ggcaaatgcg tgttttgatg ccttgaagaa aatcggctgg cctgaaggac ggatcatttt
     3601 ggcggaaacg accgtttatc tggcatgcag tcctaaaagc aattcggctt atatggcgat
     3661 taatgatgcg ttagagttgg tgaaccgtac aggaaacttg cctgttcccc ttcatttgcg
     3721 aaatgcaccg acaaaattga tggcggagct gaattacgga aaagattaca aatatgcgca
     3781 cgattatgaa aatcattttg tcaagcaaga gttccttcca aaggagattt taaacgaacg
     3841 gctgtggaaa ggacaggaaa atccgtccga acacaaacta attgaacaga tgaggcgttt
     3901 gtggggagat agatatcaga attgacaatt gataatagac aattgacaat tggggaataa
     3961 gtgtaattga taaagataat tatcatgtcg ttttgctaat aattatcaat cgtcgattgt
     4021 caattgtcaa tttattttgt acattagccg cctgtttttg aaaaaatagt tactttattt
     4081 ataataacat tctaaaaaga cattggtatg aagaagcaca atttttatgc aggtccctct
     4141 atcttgagcg agtatacaat taaaaatacg gccgctgcag tagagaattt tgcgggtatg
     4201 ggtttatctc ttcttgaaat ctcccacaga agtaaagaat tcgttgccgt gaacgatgag
     4261 gcgcgtgcgc tgatcaaaga attgctggat gttcctgctg gctatgaggt tgttttcctg
     4321 ggtggaggtg caagcatgca gttctgtatg gttccttaca acctgttgaa taagaaagct
     4381 tcttatttag ataccggtac atggtcgtcc aaagccatca aggaagctaa gctcttcggg
     4441 gaagtcgagg ttgtggcatc ttctaaagat aaaaactata catatattcc gaaagattat
     4501 acgattgccg acgatgcgga ttatttccat attacgacca ataatacgat ttacggaacg
     4561 gaaactcgca aagatccgga tgtgaaacaa cgtttggtcg ccgatatgtc gtccgatatt
     4621 ttctcccgtc cgatcgatgt atccaaatat gacattatct atgccggggc acagaagaat
     4681 ctggctcctg ccggtgtgac gttggctatt gttcgtgtgg atgctttggg gcatgtggaa
     4741 cgcccgatcc cgacaatgtt gaactataag actcatgtgg acaaggattc catgtttaac
     4801 actcctcccg tgctgccgat ctatgctgcg ttgcagacat tgaaatggta taaggaacaa
     4861 ggcggtgttg ccgctatgga aaagaaggac atggaaaatg ccgctatcct gtatgatgaa
     4921 atcgatcgta acaagttgtt cagagggact gttgcagccg aagaccgttc tatcatgaat
     4981 gtatgtttcg tgatgaatga cgaatataag gaactggaag acgaattcag caaatttgct
     5041 gcggctgccg gtatggtcgg tatcaaggga caccgctctg tcggtggttt ccgtgcctca
     5101 ctgtacaacg caatgcctaa gagcagcgtt gaagctttgg ttgcatgtat gaaggatttt
     5161 gaaaaacagc attgattatg gcaaagatat tagtagcaac agataaacct ttcgcagcga
     5221 tagctgtgaa aggtatccgc gaagtagtgg aaggggcagg cgatgaactg atcctgttgg
     5281 aaaaatacgg tgaaaaggcc aaactgctgg aggcagtcaa ggatgtggat gcaatcatta
     5341 tccgcagtga cgtgatcgat gccgaagtgc tggatgccgc caagcagttg aagatagtgg
     5401 ttcgtgccgg agccggttac gataacgtcg acctggctgc tgcgacagct cataatgttt
     5461 gtgtgatgaa tacaccgggg cagaactcca atgccgttgc cgaattggct ttcggaatga
     5521 tggtaatggc tgtccgcaac ttctataacg gaacatcggg aacagaattg aaaggaaaga
     5581 aattgggaat ccacgcatac ggcaacgtag gtcgcaatgt ggcccgtatc gcaaaaggtt
     5641 tcggaatgga aatctatgca ttcgatgctt tctgtccggc ttcggccatt gaagcggatg
     5701 gtgtgaaacc ggtcgcttca ccggaagaac tctatgctac ctgcgatatc gtttctttgc
     5761 atattcccgc aactgccgaa acaaagaact ccatcaatta cgctctggtc ggcaagatgc
     5821 cgaaaggggg cctgttggtc aatacagctc gtaaggaagt gatcaacgaa gccggactga
     5881 tcaagctgat ggaagaacgc acggacttga aatatgtaac cgacattatg cctgtggcca
     5941 acgaagagtt tgccaccaag tttgccggcc gctatttctc cactcctaaa aagatgggtg
     6001 cacagactgc cgaagccaat atcaatgccg gtattgccgc cgccaagcag atcgaaagct
     6061 tcctgaaaga aggatgtgaa aaattcagag taaataaata gatttatcta aattatcatg
     6121 gcacgaatta aacctttcaa aggaatccgt cctcctaaag atttgatcga acaagtggct
     6181 tcccgtcctt acgatgtgtt gaactcggaa gaggcacgcg aagaagcgaa gggaaatgaa
     6241 aaatcattat atcatatcat caaaccggag atcgactttc cggtcgggac ggatgaacac
     6301 gatcctgccg tttatctgaa agctgccgcc aatttccgga tgttccagga aaagggctgg
     6361 ttggtgcagg ataaggagga atgttactat gtgtatgccc agaccatgaa cggcaagaca
     6421 caatacggct tggttgtcgg tgcgtatgtg cccgattata tgaatggcgt tatcaagaag
     6481 catgagctga cacggcgtga caaggaggag gaccgcatga agcatgtccg ggtgaataat
     6541 gccaatatcg aaccggtgtt ctttgcttat cccgacaatg ccgaactgga tcagattgtc
     6601 gccaaatata catcccgcaa tccggaatat gacttcgtcg cgaaagacga cggtttcggc
     6661 catacgttct ggatcattga cgagccggct gatattgccc gcatcacgga actgttcggc
     6721 gaaatgcctt ccctgtatat tgccgacggt catcaccgtt ccgccgccgc cgccctggtc
     6781 ggtgcggaga aagccagaca gaacgcggct cataaagggg acgaggagta taactacttt
     6841 atggctgtct gtttcccggc aaaccagttg acgattatcg actataaccg tgtggtgaaa
     6901 gacttgaacg gtttgtcgga agaggaattt ctggctaaac tggaaaagaa ctttgtcgtg
     6961 gaagaaaagg gcgcggatat ttataaaccg gcagctttgc ataatttctc cctctatttg
     7021 gcaggaaaat ggtattcgtt gacagccaag caaggtacat acaacgataa cgatccgatc
     7081 ggtgtcctgg atgtgacgat ctcttccaac ctgattttag atgagattct gggcataaaa
     7141 gatcttcgtt cggataaacg catcgatttc gtaggcggta tccgtgggct gggagaattg
     7201 cagcgtcgtg tggacagtgg cgagatgaag gtcgcgttgg cgctttatcc tgtcaccatg
     7261 aagcaattga tggatattgc cgataccggt aatatcatgc ctcccaagac aacctggttc
     7321 gaaccgaaac tgcgttccgg cctggttatc cataagctcg aataaaatga tttcacattc
     7381 acaagcctgc ttgatgcttg tgtgatgccg atttacagtg aaggctgagt atgcggaggg
     7441 tgatcccgcc tgcatacggc cttcactttt tttatttggt tgtccggaca cttttatgta
     7501 agtttgtgag tattacacaa agaatatgaa aagaatcaga aacatagtat ttgatctggg
     7561 aggcgtcttg atcgacctgg accatcacca ggctgtaagc cgctttgagg aaataggagt
     7621 gaaggatgca aaacagttgc tcgatcctta tgagcagaaa ggctttttcc ttgaactgga
     7681 gaatggaaag atcgatgtcg atactttctg ccgcaagtta tgcgagcata ccggcaagca
     7741 actttcttat gatgaaatca aatatgcctg gatgggtttt attgccgatg tcccgcaata
     7801 caagttggat ttcctgttag agttgcgaaa gaaatataag gtttatttgt tgagcaatac
     7861 gaatccgatt gtccagtcgt gggcgaggag cgaggcgttc acccccgccg gtcgtcctat
     7921 atccgcttat ttcgacaaaa tgtatacttc ctatgaagtt ggggtgacga agccggatgc
     7981 cgccatcttc gaccggatga tagaaaatgc cccgcttatt cccgctgaaa cgctgtttgt
     8041 cgacgatgcc aaatcgaata tagaggttgg acaagggctc ggtttccaca cctatcagcc
     8101 ggaaaacgga gaggattggc gggaagctgt cctgaatata ctggcaaagt aatcttccag
     8161 tttgtttttg ggggagatgt ctcatgataa aaaagctata gcctgtttcc aaaaaggtta
     8221 tagctttttt cttggaaagc tatggcttgt aaacggaaaa cctatagctt ttgggaggac
     8281 ttggaacgtt ttttaggccc ccaaatatag aaaaggacaa tttgaccgca atatttcccc
     8341 tacacttttt ggaagcaata gatttatgaa aatattgtat gtgtttgata aataattgtt
     8401 tagatgattt ttctaaacct ttgcctttct tttccgtatg gaggcagtgc atgctaagag
     8461 tcaggctgtt caaatgggtc ggaggtgtgt ggaggagaat gtgtttttgt ccggatttgg
     8521 ttttttcttc gtcaggtagc tcgttattta ccgttcgtta tttaccgttc gctatttaca
     8581 aggagtattg cggttgtcgt gtaagaaaat gaggcttgtt tgaaaaagtg taggggaaat
     8641 attgcggtca aattgtcctt ttgtagggat ggttattttc aatatattga tatacagtgt
     8701 gctgtctgat gataagcttg tctttatact gtatacacct ttccaaggct tcttaatgaa
     8761 aaaggggagc cgatgggttt aataatgaac tttggccccc cttttttgta tggtaacgag
     8821 aaatattccg attacatgat accgcgttcg cgcagtcttt cctgccattt ccaggccgaa
     8881 gccaatgtgt cggccagtgt ttctgtcgct ttccagccta aaactttatt ggcacgttcg
     8941 ggattggccc aaaccttttc gatgtcacct tcgcggcgtc ctacgatttt gtgcgggact
     9001 ttaacgcctg ttgcagcttc gaatgtgttg atcagttcca atacggaaac gccattgccg
     9061 gttccgaggt tgaagatttc cacattatcc agagacttgc cacccaacat gcggtccatg
     9121 gcgatcacgt gagccttagc caagtcgaca acattgatgt agtcgcggat gcaggaaccg
     9181 tcaggcgtgt catagtcgtc accgaataca ctcagctctt tgcggatacc catagcagtc
     9241 tgtgtcagat acgggatcag gttctgagga acgccgttag gcaattcgcc gatctctgct
     9301 gtcggatgtg ctccgatcgg gttgaagtaa cgcaggatga tgctcttgaa aggagcgccg
     9361 gcatggatcg tgtcgcggat gatctcttcg ttgatctgtt ttgtatttcc gtatggagaa
     9421 gtagccggtt tgatcggagc gttctcggtt acaggcagat tctcagggtc aggctgcccg
     9481 taaacggtgc aggaagacga gaatacaatg ccttcgatat tgaattccgg catcagttcc
     9541 aacaggttca ccaatgtcac aacgttgtta cgatagtatt tcaacggttg ctgtacggat
     9601 tcgcctactg ctttgctggc ggcaaacagg atgatccctt tgattcccgg atgagctttc
     9661 agtgcttcgc gggttccttc cttatctttc aagtccagct tgatgaattc aggacggatg
     9721 cctgtgatgc gttcgatacc gtccaatact tctatattgg agttagacag gtcatcaatg
     9781 atgacaactt cataacctgc gttttgcagt tctactgtgg tgtgtgatcc gatgtaacca
     9841 gttccacctg ctactaaaat cttctgtttc atgaggagag aaaatttatg atttatgatt
     9901 tatgaaagga tttatgattt atgatttata gcggcaagcg gtgttacctg ttattatcaa
     9961 gcagtattac ctgttattat aaatcataaa tcataaatct ttaaacgatc cccgagaatc
    10021 ccataaacgc catagccagc aggccagctg tgattagggc gatcggggtt cctttcatgc
    10081 catcggggac atttgtcatt gctaattgtt ctctgacacc tgcaaagata atcaaagcta
    10141 atgcaaatcc aatagcaata gagaatgcat atactacaga ttctaataaa ttatactgtt
    10201 tctggatgac ctggatggcg acacccaaca cacaacagtt tgtcgtgatc agcggaagaa
    10261 acactcccaa tgcctgatag agggcaggag aaactttctt caggatgatt tccaccattt
    10321 gtaccagagc tgcgataatc aggatgaagc tgatggtctg cataaagccc aggccgaata
    10381 catccagcac atatttttgt acgaggaaag tcacgagtgt cgcaatggta agcacaaatg
    10441 caacggctgc tcccatgcct attgctgtat ccactttctt ggatacgccg aggaacggac
    10501 atatacccaa gaattgggac aacacaacgt tgttgacgaa tacagcggcg ataaatatca
    10561 atatatattc catatcttac cttgttttat gctttacgca gtttattaac aatagctatc
    10621 aggaatccca gtgcgatgaa tgcacccgga gccaatacga aaatcagcga gccgaactgt
    10681 tccggcatga ttgtcaggtt gaacagttta cccgtcccca acaattcgcg gatagctcct
    10741 aacagtgtca aggcaatcgt aaagccgaga ccgataccga ttccgtcgaa agccgaggcc
    10801 acgactccgt tcttggcggc aaaagcttcg gcgcgtccca acacgataca gttgacgacg
    10861 atcaacggga tgaacaatcc caaacttgcg tataaggcag gaataaatgc ttccatgcac
    10921 atttgcacaa ccgttacgaa tgtggcgatt acgacaatgt acccgggaat acggaccata
    10981 tccgggatta catttttcaa tgctgatatg accatgttgg aacagatcaa cacgaacatg
    11041 gtagcaagtc ccatactcat accattcatc gctgaagagg tcgttcccaa tgtcggacac
    11101 atacctaaca gcaatacgaa tgtcgggttc tctgtgatga ttccgttcat caatattttc
    11161 agattactca ttgtcgtttc ctccctcttt agttgtgtta tcggatgatg tggttgctcc
    11221 ggtcaatccg tcggcaccgg aaaaagcact gtaggcgcgg ttcacagcgt tcaggaatgc
    11281 acggctggta atggtcgaag ctgttatggc atcgacatct ccaccgtctt tggttacttt
    11341 cagttcgcca tcagacaaat tgcgtcccaa aacgctctgg cgatttttgt ccgtacggaa
    11401 ccattcttgc attttagccc ctaatccggg tgtttcggca tgttgcaaga ctgaatagtt
    11461 cagcagtttg ccttcggtgt caaaaccgac aatcacgcgg atctcaccgc cgaacccttt
    11521 cattgtgttg ctctccactg cggcaccgac gaatttgccg tcttgttttg ccgggtagat
    11581 tttcagcgag tcgccatcgg ctgtaactgc catataggct tcttctgtcg gtttgttgtc
    11641 gaatgccgga gtgaccgctt tgatcgctgc ttccagcgct gctgctttgg tggcggcaat
    11701 cggaccggtg gtgtacatat tcacacctgc taatattgct ccggccacta cacagatgat
    11761 cgtgagtgaa aggaacatat tgggtaatgt tgattttagt tttgccatgc ttatttccct
    11821 ccgaaatgtt taggtttcat ataactgttg atgagcggag taactccatt catgatgaag
    11881 atggcaaatg acataccttc gggataagaa ccgaacagac ggataaccgt tgtcaggata
    11941 ccaatgccga caccgtagac aatcataccg ctcttgctca tcggcgaagt cacatagtcg
    12001 gtcgccatga agatagctcc caacatcaga cctccggaca acagatggac gaacgggctt
    12061 gcgtattgaa ccggattcac caggtgcatg atacctgtaa agacaaatac cgtgacgaag
    12121 atggataccg gaacgtgcca ggtgatgatc ttcttccata acatatagaa catacctaac
    12181 agcagtgcca gtgcgctgac ttcaccaagg ctaccgccca tgttaccgat cagcatgtcg
    12241 ctgagtgtag gcattttgtc gagtgcaccc tcgttcatca gagagaggac ggttgcccct
    12301 gttgttgcat cggcataaga tgtcaactgt ccgacaacgg gccaggtggt catctgtgcc
    12361 gggaaagaga tcagcaggaa gatgcgtcct gtcagtgcag ggttgaaaat attgttgccc
    12421 aggccgccga acgacatctt accgataccg atggctgcca gcgcaccgat ggcgatgatc
    12481 cagatcggca ggtttgacgg caggttgaac gccagcaaaa caccggtcag gatggccgaa
    12541 ccgtcgtaaa tggtcggttc ctttttcatc aggaacttct gaatcagata ttcgaacagg
    12601 acacagaaga aaaccgaggc tacggttacg atcagcgcac ccagtccgaa aaagtagagt
    12661 gataccagga aagccggaac aagggcaatc agtacaccgt acatattttt acttatgctg
    12721 tcgccgccat gaatgtgggg cgagggagac acgtataatt tgttttccat attgctcttg
    12781 ttttatgact ttcttgcacg aataataccc ataactttgc ctttacccaa tcggatctgg
    12841 tctaacagcg gacggtgggc agggcaagta taactgcatg aaccgcattc gatacagtcc
    12901 tggatgtagc ctccttcagc cttttcccaa tccttataga tcgtgaattt catcaggaag
    12961 gccggattca accccatcgg gcagacgttc acgcacttgg cgcaacggat acagtcctgc
    13021 atcggtttgc ggacagattc ttccttggtc aggagcaata cgccggaact gcctttggtt
    13081 accggaactt cggcgcttac caacgctttg cccatcatcg gaccgccacc gataatctta
    13141 cccgtgtttt cgggaatacc accggctgct tcgatcagcg tgttgatagg cgtacccata
    13201 cggaccagga agttcgacgg gttggcaacg gcttttcctg ttacggtcac gacgcgctcg
    13261 aacagaggtt tgttcttctg gacggcttcg tagacggcgt aggcggttcc tacgttctgt
    13321 acgacggctc cggccgagat aggcagggcg ccgctcttta cctggcgacg gatcacggcg
    13381 tcgatcagct gcttttcacc tccttgcgga tattgcactt tcagcggcat gatctcgatt
    13441 ccgggataag cggctgccag cttcgtcagg tgggcgattg catcgggttt attgttttca
    13501 atgccgataa cggctttgtt tacatttacg gctttcatca gcaatgtgac gcccaccaat
    13561 atctgttcgc ctttttccat catcagggaa tggtcggagg tcaaataagg ttcacattct
    13621 acggcattga tgatgatgat ttctgccttg cttccgggag gcggcatcag tttcacctgt
    13681 gtcgggaaag tggctccccc cagacctacg ataccggctg ctgcaatctt gtcgacgatc
    13741 tctttggatg acaacgtaca atcttttacc aatgcatcgc tgcggtcgat cgtttcttcc
    13801 cattcgtctc cttccacatc gatgtagatg gcgggacgct tgtagccgct tgagtcgagg
    13861 gcgttatcta ttttgtttac tttaccggat actgacgagt ggatattggc ggaaacgaaa
    13921 ccacctgcct tggcgacaag tgttccgact ttaaccagat cacccttctt gaccactgcc
    13981 tgggctggag ccccgatgtg ctgactgagc ggtatgatta cctgcttagg agcagctaaa
    14041 gcggtaattt tcttaccggc agacaattta ttttcgggcg gatgtatacc tccgattcga
    14101 aatgtcctta gcatactatt agattttatt tttgaattgt ttcttctttt gtttcaactt
    14161 taggagttgc tgcatttggc gtagcgtttg ctgttggagc ttctgccttc ggagactctt
    14221 tcttcgggac ttcagtcttt ggcgcatcag ccttcggtgc agccggtttc ggagctgttg
    14281 ccggttttat tttgtcggcg tccacagccg gagctgcctc tttacgtggc gggaagttca
    14341 attcgtggat ggcgccggtc ggacatacgg ctacgcactt gcggcataag cgacattttg
    14401 tgtaatcgat gtaggccacg ttgttttcca ctgtaattgc ttcgaacggg cattcctttg
    14461 cacatttgcc acagccgata caagcgttag cgcatgcttt cttggctact ccgcctttgt
    14521 ctttgtttac gcagctgacg aagacgcggc gtgatttggg gcccttctta cgcagttcga
    14581 tgatgttttt cgggcaagct tttacgcaag ctccgcatga agtacatttg tcttcgtcca
    14641 cttccggaag cccggtctca aggttgatgt ggatggcgtc gaagttacat gcagccacac
    14701 agtcgccata acctaagcaa ccgaatgaac agccggtctc tccgccgtac aaggtggaag
    14761 caatcgcaca actctgcaca ccgtcgtatt ggttggtacg cggacgggcg gcacacgttc
    14821 cgttgcagcg gacaacggct accatcggtt ctgcactggc tgcttctttt ccgaggatgg
    14881 tggctacttt gcccattaca ggtgctccgc ctacggggca taacaggccg tccaacgtgt
    14941 cggcttttac acaagccgta gcaaaaccac cgcatccggg atatccacaa cctccgcaat
    15001 tggctccagg caatacctcc tggacttgtg cgatacgagg atcttcgtat acttcaaact
    15061 tcttggaggc ggcgtataga aaaactgcgc cgatggctcc aatcgctcct aatgaaataa
    15121 cggcaattaa aatcatgata tgtttgtcaa ttaagttttt tcaaagtaaa tatgaatcgc
    15181 tttttcagtt tgtcgcgtaa aaagtataat atgcaataat aaggaactaa gagcagtaat
    15241 ccggttaacc cgcttgtggt ttcttcccat tgcatacttg tacctgttac aatagccgca
    15301 aaaactatga tgagcggaaa tacaaatgca agaagtacgg cctgcagccc cagtgaactt
    15361 tgtccgcata actggacttc ttcatttata tggaattttc cagagttgtc cggaacctcg
    15421 atgatctttt ctttgctctc ggatgccgta cacatacttt tcgcatggca tccggagcaa
    15481 gccgattgtt ggatgatcct gacatagacc gtaccgccgt cgatcttctc tataatccca
    15541 ttgtgattga tactttcgct catatttgta atctcgacat tgcaaaaccg aggcaaaagt
    15601 acgtattatt tggaaattat gtcacgatta acaaagttta ttatggaaat aatagac
//
