LOCUS       c00463_gnlPro..        14798 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EMOPLLNF_463.
ACCESSION   c00463_gnlPro..
VERSION     c00463_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 13:52:28
            Original ID  :: gnl|Prokka|EMOPLLNF_463
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 37699
            Orig. end    :: 52497
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14798
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[47699:52256]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14557
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14798
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14798
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(36..557)
                     /locus_tag="ctg463_27"
                     /transl_table=11
                     /translation="MSTINYDLSRIKALAFDVDGVLSSTTVPLHPSGEPMRTVNIKDGY
                     AIQLAVKKGLHIAIITGGRTEAVRIRFEGLGVKDLYMGSAVKIHDYRAFRDKYGLTDDE
                     ILYMGDDVPDIEVMCECGLPCCPKDAVPEVKSVAKYISYADGGRGCGRDVVEQVLKAHG
                     LWMVEDAFGW"
     CDS             complement(538..1332)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg463_28"
                     /sec_met_domain="F420_oxidored (E-value: 8.3e-14, bitscore:
                     43.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYRKGFRIVQVYSRTMESAR
                     TLAEKVEAEYTTDLQAVSKDAKLYIVSLKDDALVDLLPQITEGKQASLLVHTAGSIPMS
                     VWEGHAERYGVFYPMQTFSKQREVKFQEVPFFVEAKRPEDVELLKAVAATLSEKVYEAS
                     SEQRKSLHLAAVFICNFTNHMYALAADLLEKYNLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMSNHLAMLVDSPALQEIYKLMSKSIHEHHQL"
     CDS             complement(1340..1675)
                     /locus_tag="ctg463_29"
                     /transl_table=11
                     /translation="MGAAKANNSKDTYLATAVTFIVIGALYLIDKLIHFSSIGLPWVMN
                     KDNMLLYASICFLIFKRDKSIGFVLLGLWLVMNIGLVMSLLGSLSGYLLPLTLLIIGIV
                     LFWFAKR"
     CDS             complement(1678..2214)
                     /locus_tag="ctg463_30"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDQVVALMKAALMSPSSKRSNS
                     WQFVVVDDKEVLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILDIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             2337..2561
                     /locus_tag="ctg463_31"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIEMYGHPICHQRVHQSKKVYNRR
                     KIKAADKKLPYFFVFKIASLSSRHSDTIQ"
     CDS             complement(2650..3192)
                     /locus_tag="ctg463_32"
                     /transl_table=11
                     /translation="MLEEILAYNKQFVENKGYESYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EVMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVRHPLIPSDVT
                     VYGFIIDSTTGELTRIV"
     CDS             complement(3299..5323)
                     /locus_tag="ctg463_33"
                     /transl_table=11
                     /translation="MKSTIYKIAALTFAVASMSACSLDEYNPSQKTGDEILATFDGLKG
                     LQSYCYSSLYGQLFSVYDFLSVAEGGTDCWITPAGNPDYAKQVIYYDGLATNTNATNKL
                     FGQAYSMIGNCNAVVNRAELLTDGNEKDITTLVAEARCLRAFYYSILVNTYGNVTLTLE
                     ESSQDPILTPQRNSIEELYTQIIDDLKFAANNLEDAPYDNNRARVTKKTALGLLARVYA
                     QGGGEYGLTEDGVSYWQRAKEVAEDMILAYGDCLYDDVEDVWAPANNRNNKEALFIAAG
                     PDATNLENWNAGTQCNNNFTYMYPKPNTLTIYPTPDNQNYWYGRTNNNTLAPSKYLLDC
                     FDADYDKRWEVTFTTAFVQFSAVQSGGSYLFTNKKQTLDDGTKPKIGTKHGVNDNISSF
                     TILTQNIIDTYGLDAKFHNEYIYPYGDLNYTYYDGTWAPKMIAKVWPKGENSGDPSKLQ
                     EVKNPYVIPYPVAEDDDRICFYLSKERLSDAEKAKRRYYVINIDDLFDNGQYRKTDIKV
                     TNDKNMYPGFNKYNWLSEDSYSSNLQRKTGDVFIMRMAEVYLIAAEANQQLGNGGKAAE
                     YLNVLKKRAARNDASYNAMKLSNATQNDVMDEYARELCGEYQRWVLMKRHKDSFKQRLA
                     VGNPRAAENFDENKHYLRPISFNFLSQIDNAEEYGNNGY"
     CDS             complement(5348..8587)
                     /locus_tag="ctg463_34"
                     /transl_table=11
                     /translation="MRCNAFVEAWKNHHRRASMILGLSLLAAPLSYAVYAEDGVSNTMV
                     QVVTQTKTVKGTIIDESGEPLIGVSIVVKGTSTGTITDFNGNFSIDLPAGRKELVISYI
                     GYKEQTVTVTGNGPVNVKMVSDTQALDEVVVVGYGTMKKRDLTGAITSVKSEDVVMNPS
                     SNPMQALQGKVAGLDITRESGQAGSGVKMQLRGNRSFQKDSGNPLFIIDGMPGDYSTLN
                     PNDIESIEVLKDASSTAIYGSSGANGVILITTKGGKEGKAIVNFNAYVGVNGWSRTPEM
                     RSGESYIQTLRDASVGAGDGRWSSVADDKNLFTTDAEWSAHQNGQYIDWVDALLKTSVT
                     QNYSVSVAGGTEKTKAYFSLNFSNEDGQFAQDSYKLYSSKIRVDHKIKKWMKVGIDAQL
                     SYVHQNKADSDLQTLMASNPLGSLYNEDGSINPQPVADPSSTVYNYLLNEDKSLYRNQA
                     QNLKVYFNPYLEITPLKGLTFITRAGASLGYSRSNTFTGEGSVQWYKANQTADGIKAQV
                     KDNRSYNYKWENILTYNFQIKKVHDITLTAVTSWNHNRSDVTTLYQKGVSDNKFLWHNI
                     LDGNSATSGSTSYSMSKGMGYVGRLNYSYMGRYLFAASVRHDGSSRLAEGNKWDTFPAF
                     SLGWRISDEKFMESTTNWLSNLKIRFGYGVTGSTAGIDPYSSAASLDATAVNMILGGVL
                     TPIYKFSQNIPNYLLTWEKSYNTNIGIDAAFLNNRIDVSMEYYNTKTKDVIWNKALPVI
                     NGAFSPDGGPKANYTTNLNMCETSNKGFELALNTRNIITKNFTWSSSVTFNHNKEKITK
                     LSGGDSDVLNNGDTGYALALGEAINSYYHYKLDGVWQKGEETDAAVFGAAPGDLKINIP
                     NLVKESDGRFYKIDEETGSAAVDENGNVIYYTSDNKYTPSDADYQILGHNSPDWSLGFQ
                     NNFTWKDFDLSVFVYARYGQMFAYDMLTSYDPKGIRNFPTYFNYWTENNPSNDFPAANA
                     NKGLEQYTGYYALRYVDGSFIKIKNITLGYSLPKSILKSAGIEKCRFYATITNPFVFAK
                     SHLLKDYDPEMNGSLKYPLTKQFVFGVNVTF"
     CDS             8827..9825
                     /locus_tag="ctg463_35"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNTFHSKELFLIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKTKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRTNDYFPVNWLRVRNSLHSMKKTEDRFSPSRI
                     RQIKKGLKNGAKVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNNMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDAHQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWSWLNKLLVKFYV"
     CDS             10001..10405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg463_36"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.1e-23, bitscore:
                     75.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAEGKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             10434..11987
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg463_37"
                     /sec_met_domain="CT_Btheta (E-value: 6.4e-290, bitscore:
                     953.0, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             12019..12939
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg463_38"
                     /sec_met_domain="OAD_gamma (E-value: 2.2e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGKKLLDQIVVPAGTLGPNQSYARVSDGAAEW
                     EVKSGSGDKYVTPSTNNKTLDSNSKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             12964..13395
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg463_39"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.3e-21, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPAAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             13397..14557
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg463_40"
                     /sec_met_domain="OAD_beta (E-value: 2.3e-153, bitscore:
                     501.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLVFIYLAIAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFVIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
ORIGIN
        1 tattcgttat taaacaacga ttatttatga ttaagttacc aaccgaaggc gtcttccacc
       61 atccatagac cgtgagcttt cagcacctgc tccactacat cacgtccgca tccacgacca
      121 ccgtctgcat aagaaatata ctttgcaacg gatttcactt ccggcacggc atctttcggg
      181 cagcatggca gtccgcactc acacatcact tcaatatccg gcacgtcatc acccatatat
      241 agaatttcat catcggtcaa tccgtactta tcacgaaaag cacgataatc atgtatcttc
      301 acagcagaac ccatgtataa atccttcact cccagtccct caaaacggat acgtaccgct
      361 tctgtccggc caccggtgat gatagctatg tgaagtcctt ttttcacagc caactggatg
      421 gcgtacccat ctttgatatt caccgtgcgc atcggttctc cggaaggatg caaaggtacg
      481 gttgtcgaac tcaatactcc gtccacatca aaagctaaag ctttgatacg ggataaatca
      541 taattgatgg tgctcatgga tacttttgct cattagttta tatatttcct gcaatgccgg
      601 agaatctacc aacatggcaa gatgattact catcacattc tcatcgtaac gaacagcggg
      661 tccggtctgt gcatcacgtg gcgccaattc gtggacttta cgtgctgttt catctatcag
      721 cggaagcatg acatcgaaag gcaagttgta tttttcaagc aaatcagctg ctaatgcata
      781 catgtgattg gtgaagttac agataaaaac agcagccaaa tgaaggctct tacgttgctc
      841 ggaagaagcc tcgtagacct tttccgaaag tgtggcggca acagccttca acaattccac
      901 gtcttccggc cttttcgctt caacaaagaa aggcacttcc tgaaatttaa cttcacgttg
      961 tttgctgaat gtctgcatcg gataaaatac tccgtaacgt tctgcatgcc cttcccaaac
     1021 gctcatcgga atgcttcctg ccgtatgcac caacaaagac gcttgctttc cttctgttat
     1081 ctgcggtaac aaatctacta aagcatcatc tttcaacgat acgatataca attttgcatc
     1141 tttggagact gcctgtaaat ctgttgtata ttcagcttct actttctcgg ctaaggtacg
     1201 ggcagattcc atagtccggc tatatacctg tacaatgcgg aaacctttac gataaagagc
     1261 tttcgccaga ttagtagcca agttacctgc accgataaac acgatcggtg tatcttctat
     1321 acttcttttc attattctct tatcgttttg caaaccagaa taaaacgatt ccgatgatga
     1381 gcagtgtcaa tggcaacaga tatccggata acgaacccaa taaggacatg accaaaccga
     1441 tattcatcac tagccaaagc ccaagcaaca caaaaccaat tgatttatcg cgtttgaaaa
     1501 taaggaaaca gatcgaggcg tacaatagca tattgtcctt attcatcacc caaggcagtc
     1561 caatggaaga gaaatgaatc agtttatcaa tcagataaag tgctccgata acgataaagg
     1621 taacagcagt agccagatag gtatctttac tattattcgc tttagcagct cccatactta
     1681 ttttcctccg aacttgttaa tatgaatttt ctcccattga agatgttctt cattgaaagg
     1741 tttacgttcc atccctttat gtccgatagc aatgacagaa agaatctgaa gttgcaaggg
     1801 aatatccaaa attccatgga caaattcatc ggaaggcatt ccggtggcag tgaaacgttc
     1861 gcgaacctgc acccaacaac ttcccaagcc aagatcttca gcctgcaact gtatcatgat
     1921 ggaagcaatg gaagcgtctt caatccaaac atcgctggcc aacggatcgg ccattacaac
     1981 aatcgccaaa gctgcatcgg caatgaacga agaagcctgt tctttgcaat gagacaattc
     2041 tttcaatacc tctttatcat caaccactac aaactgccaa ctattactac gtttggaaga
     2101 aggggacatc aaagctgctt tcatcaacgc aactacctga tcttgtgtca attcttcatc
     2161 ggtgaacttc cgcatactac gacggttctt tattaattca ctgaaatttt ccatattatt
     2221 tccggtttca tttgattaat gtatgcaaag ataatgcaaa ccgagcgtaa taggaaataa
     2281 aagtttatac taaatgaaga atatattgta tctttgcaca gagaaataat ttcattatga
     2341 aaaagcgaat tacacaagac gattacatta aagcgaatcg taaagctagc cgtgaggcag
     2401 aaatagagat gtacgggcac cctatttgtc accaacgagt gcaccagtca aagaaagtat
     2461 ataaccgcag aaagataaag gcagccgaca aaaagctgcc ttattttttt gtcttcaaaa
     2521 tagcgtcact atcctccaga catagcgaca ctatacaata gaaatggcgt cactatcatg
     2581 ataggatagc gtcactatat ttaggggatt aaaaaagaag tttatctatt tacctatcta
     2641 tctaataatc tatacaatcc gagttaattc tccggtcgta gaatcaataa taaacccgta
     2701 gactgtcaca tctgaaggga tcaaaggatg acgcacaata aaatctaccg ttcctctcac
     2761 cgacttttct gtatcttcga aaccatccag ccacgaatga aagtcaactc cgcagaaacg
     2821 catcatatca atataatccg gattgattcc gcgtgctttc attttttcga gcattacttc
     2881 actgtgcatg tggcaagctc cacagtcaga atgagcaatc accattattt cctctacccc
     2941 caactcaaaa atagctacaa gtaaactacg tatcacgcta ccgaaaggat gggaaataac
     3001 gccacctgca ttttttatca ttttcacatc gccattctta attcctaatg ctgctggcag
     3061 caaagcagtc agtcgggtat ccatacagga aagaatagct attttcttat cgggatattt
     3121 attggtaata tacgattcgt atcccttgtt ctcaacaaat tgcttgttgt aagctaaaat
     3181 ttcttctaac atagttccgc tttttaaaag ttctgttcga ttacacaaag atatagaaaa
     3241 aagggacata tcatcacgac atatcccctc tttaatctaa atttaatctg taagagtact
     3301 aatacccatt gtttccatat tcttctgcat tatcaatctg actcaagaag ttaaaagaaa
     3361 tcggacgcaa ataatgcttg ttttcatcaa aattttcagc tgcacgagga ttaccaacag
     3421 caagacgttg tttaaaagaa tctttgtgac gcttcatcaa tacccaacgt tgatattctc
     3481 cacataattc acgagcatat tcgtccataa catcattctg tgtagcatta ctcaatttca
     3541 tagcattgta agatgcatca ttgcgagcgg cacgcttttt cagtacattt aaatattcag
     3601 cagcttttcc gccatttcct aattgttggt tagcttcagc tgcaatcaga tatacttcag
     3661 ccatacgcat aatgaacaca tcacctgtct tacgttgcaa attgctacta tatgaatctt
     3721 ccgacaacca attgtatttg ttgaaaccag ggtacatatt tttgtcatta gtaactttta
     3781 tatctgtttt acgatattgt ccgttatcaa acaaatcatc aatattgatt acataatatc
     3841 tacgtttcgc tttctccgca tccgaaagtc tttcctttga taagtagaaa cagattctat
     3901 catcatcttc agctacaggg taaggtatca cataggggtt cttcacttcc tgcaatttgg
     3961 aaggatcacc gctattttca cctttcggcc aaaccttggc tatcattttg ggcgcccaag
     4021 ttccatcata atatgtataa ttcaaatcac cataaggata aatatactca ttatggaatt
     4081 ttgcatccaa tccataagta tcgattatat tttgagtaag aattgtaaat gaactaatat
     4141 tatcatttac gccatgtttt gttccaattt ttggttttgt accatcatcc aatgtctgct
     4201 tcttattagt aaataaataa ctacctcctg actgtacggc agaaaactgt acaaaagccg
     4261 tagtaaaggt tacttcccac cgcttatcat aatcagcatc aaaacaatcc agcaaatatt
     4321 tggaaggtgc caacgtatta ttattagtac gtccatacca ataattttga ttatccggag
     4381 taggataaat agtgagagta tttggctttg gatacatata agtaaagttg ttattacatt
     4441 gtgttccagc attccaattc tccaaattcg tagcatccgg accggcagca ataaataaag
     4501 cttctttatt atttcgatta tttgccggag cccaaacatc ttccacatca tcatacagac
     4561 agtcaccata cgctaaaatc atgtcctctg ccacttcttt agcacgttgc caataagata
     4621 ctccatcttc tgtcagccca tattcgccac caccttgagc ataaacgcga gctaaaagtc
     4681 ctaacgcggt tttcttagtc acacgcgcac gattattatc ataaggagca tcttcaagat
     4741 tattggccgc aaatttcaaa tcatcaatta tctgcgtata tagttcttca atagagttac
     4801 gctgcggagt caaaatagga tcttgagacg attcttccaa ggttaacgtt acatttccat
     4861 acgtattcac caatatggaa taataaaacg cacgaagaca gcgggcttca gccactaacg
     4921 tcgttatatc tttttcattg ccatccgtta gtaattcagc cctgtttact actgcattac
     4981 aattaccgat catagaataa gcctgaccga ataatttatt tgtagcattc gtattcgtag
     5041 ctaaaccatc ataataaatc acctgcttgg cataatccgg attaccggca ggagttatcc
     5101 aacagtccgt accaccttca gccacagaca agaaatcata gacactgaat aactgcccgt
     5161 aaagtgatga ataacaataa gactgtaatc ctttaagccc atcgaacgtt gcaagaattt
     5221 catctcctgt tttttggctt ggattatact catcaagcga gcaggcagac attgaagcca
     5281 cagcgaatgt aagcgctgct attttataga ttgtactttt catttcaata ctttttttag
     5341 tgaaaaacta gaatgtaaca tttacaccaa atacaaattg tttggtcaat ggatacttca
     5401 gagaaccatt catttcggga tcatagtctt tcagcaaatg gcttttcgca aatacaaacg
     5461 gatttgtaat ggtagcatag aaacgacact tctctatacc ggctgatttt aagatagatt
     5521 tcggcagact atatcccaat gtaatgttct taatctttat aaacgaaccg tctacatagc
     5581 gtaatgcgta atatcccgta tattgttcga gacctttatt agcattggcg gcaggaaaat
     5641 catttgaagg gttgttttca gtccagtaat tgaaataggt cgggaagtta cgtataccct
     5701 tcgggtcata agacgtcaac atatcataag caaacatctg tccgtaacgt gcataaacaa
     5761 acacacttaa atcaaaatcc ttccaggtaa aattattctg gaatcctaaa gaccaatccg
     5821 gagagttgtg acccagaatt tgataatctg catcacttgg agtatattta ttatcagaag
     5881 tgtaataaat aacattacca ttttcatcca cagcagcact acccgtttct tcatctattt
     5941 tatagaatct accatcagat tcttttacta aattaggtat attgattttc aaatcaccag
     6001 gtgcagcacc aaataccgcc gcatcagttt cctcaccttt ttgccataca ccatccaact
     6061 tataatgata ataagagtta atagcttctc ccaatgccaa tgcataaccg gtgtcaccat
     6121 tattaagcac atctgaatct ccaccggaca atttggttat tttctcttta ttatgattga
     6181 aagttacact tgaactccag gtaaagttct ttgttataat attacgtgta ttaagagcca
     6241 actcaaaacc tttattgcta gtctcacaca tatttaaatt agtagtataa ttcgctttag
     6301 gtccgccatc cggggagaat gctccattaa taacaggaag tgccttgttc catataacat
     6361 cttttgtttt tgtattataa tattccatac tgacatcaat gcgattattt aagaatgcag
     6421 cgtcaatacc aatattcgtg ttatacgact tttcccatgt aagcaaatag ttcggaatat
     6481 tctgtgagaa tttataaatc ggcgtcagaa cacctcctaa tatcatattt acagcagtag
     6541 catccaatga tgcagcagac gaatacggat caatacccgc tgtactaccc gtaacaccat
     6601 atccgaagcg aattttcaga ttactcaacc agttagtcgt actctccata aatttttcat
     6661 cagagattct ccatcccaaa gaaaaagccg ggaaagtatc ccatttatta ccttctgcca
     6721 gtctggaaga gccgtcatgg cggacagatg cagcaaataa atacctaccc atatatgaat
     6781 agttcaaacg gccgacatat cccatcccct tagacatact ataagaagta cttcccgaag
     6841 ttgcagaatt accatcaaga atattatgcc ataagaattt attatcagaa acaccttttt
     6901 gatacaaagt agtgacatcg ctacgattgt ggttccacga tgtaactgca gtaagagtta
     6961 tatcatgcac tttcttaatc tggaaattat aagtaagtat attttcccac ttataattat
     7021 acgaacggtt gtccttaact tgcgccttaa tgccatctgc cgtttgattt gccttatacc
     7081 attgaacaga cccctctcct gtgaaagtgt tactacgtga atatcccaaa ctagcaccag
     7141 cacgagtaat aaaagtcagc cctttaagag gagtgatttc caagtaagga ttaaaataga
     7201 ccttaaggtt ttgagcctga ttgcggtaca aacttttatc ctcatttaaa agataattat
     7261 atactgtaga tgaaggatcg gcaacaggtt gcggattgat gcttccatct tcattataca
     7321 acgatccaag aggatttgac gccatcaaag tctgtaaatc agaatcagct ttattttgat
     7381 gtacataaga cagttgagca tcaatgccca ccttcatcca ctttttaatc ttatgatcta
     7441 cccggatttt agatgaataa agtttatagc tatcttgtgc aaactgccca tcctcattag
     7501 agaagttcag agaaaaatat gcctttgtct tttccgttcc accagccaca gaaacagaat
     7561 aattctgtgt tacactggtt ttcaacaaag catccaccca atctatatat tggccatttt
     7621 gatgtgcact ccattcagca tcagtagtaa acagattttt atcatcagca accgaactcc
     7681 aacgtccatc gccagcacca acagatgcat ctctcaaggt ttgtatataa ctttctccac
     7741 tacgcatctc cggagtcctt gaccagccgt ttacacctac gtatgcatta aaattaacaa
     7801 ttgctttgcc ttccttacca cctttagtag taattaaaat aacaccgttc gcaccacttg
     7861 aaccataaat agctgtcgaa gaagcatctt ttaaaacttc aatgctttca atatcattcg
     7921 gattcaatgt agaataatcc cccggcatac catcaattat aaataaagga tttccggaat
     7981 ccttctggaa tgaccgatta ccacgcaact gcatctttac tcccgaaccg gcctgtcccg
     8041 attcacgcgt aatatccaat cctgccacct taccttgtaa agcctgcatc ggatttgaac
     8101 ttggattcat cactacatct tcacttttta cagaagtgat agctcctgtc aaatcacgtt
     8161 ttttcatcgt accgtaaccc acaacaacca cttcatccaa tgcctgtgtg tccgaaacca
     8221 ttttcacatt gaccggtccg ttgcccgtca cagtcaccgt ttgttctttg taaccgatat
     8281 aagaaatgac cagttctttt cttcccgccg gaagatcgat agagaagtta ccgttaaaat
     8341 cggtaatcgt acctgtactt gttcctttca caacgataga aactccaatc agcggctccc
     8401 cgctttcatc gatgatagtt cctttcacag ttttcgtttg tgtgacaact tgcaccatag
     8461 tattagaaac tccatcttct gcataaacag cgtatgacag aggggcagcc aataaagaca
     8521 accctaaaat catggaagcg cgtctatgat gattcttcca tgcttcaaca aatgcattac
     8581 atctcattcg ttctaattta aagttaatat taattctcgt tgttttgcaa aaactattcg
     8641 attataatct taattaagga cgaatctaat tttaatacgt actcactttt cataccatat
     8701 ttcttctata aaatatattt tctccattaa atacgcaact atatattata ctttacttca
     8761 agcagctcca acaaattctt tattttgttg ttgaataaag aataaaaagt gtaaatttgt
     8821 acctagatgc cactgaaact aacaacatat tatcatggga aggatattcc tgaattgccg
     8881 ggaaaaaata ccttccattc caaagagtta tttctgattt atgaagcaac tcctgggtat
     8941 actcctttat taatagtggc aacagaagac ggcagaccgg tggcacgcct gcttgctgcc
     9001 atccgcaaaa caaagaagtg gctcccttct tctttagtga aacattgtgt agtatatagt
     9061 gaaggcgaat ttctggacga gtctctttcg accaacaaag aaaaggcaga agaagtcttc
     9121 ggcgatatgc tcgaacatct cacacaagaa gcatcgcgca gctgtgtcct gatcgaattc
     9181 cggaacctga acaattcgat gttcggttat cgggttttcc gtaccaacga ttatttccca
     9241 gtcaactggt tgcgggtacg caattcgctg cacagtatga aaaagacgga agaccggttc
     9301 agcccgtcgc gcatccgtca gataaaaaaa ggactcaaga atggagccaa agtagaggaa
     9361 gcacataccg tggaagaaat acacgatttc tcacggatgc tgcacaaggt ttattcctcc
     9421 cgcatacgca gatatttccc ggccaacgat tttttccgcc acatgaacaa tatgttaatc
     9481 aaaggacaac aggcaaaaat attcgttgtg aaatacaaag agaaaatcat tggcggttct
     9541 gtctgtatct attcgggaga cgacgcatac ctttggtttt cgggaggaat gagaaagaca
     9601 tacgcacttc aatatccggg tgtgctagcc gtttggaaag cattggaaga cgcacaccaa
     9661 cggggattcc gccacatgga atttatggat gtaggacttc cgttccgtaa acacggttat
     9721 cgtgatttcg ttcttcgctt cggaggaaaa caaagcagta cccgccgttg gttccgcgtc
     9781 aattggagtt ggctgaataa actcttagtc aagttttatg tctaaatgta atctcaagat
     9841 tacaaaacaa tgttttatgc tcctttccca ccattttttc tgtttaataa tccaataatt
     9901 aaatgcagaa atatttcttt attagataag aaatgtcttt ctttgtgctg ttttatgcct
     9961 tataagcaca gatttaaaac caaataaaaa aagtatagtt atgaagattt cacacattga
    10021 acatctgggc attgctgtaa aaagcatcga agaagccctt ccttactacg aaaatgtatt
    10081 aggtctgaag tgttacaaca ttgaaacagt ggaagatcag aaagtaagaa ctgctttttt
    10141 aaaagtgggc gaaacaaaaa ttgaactgtt ggagcctact tgcccggaga gtactattgc
    10201 caaattcatt gaaaacaaag gtgcaggcgt tcaccacgtc gcatttgctg tagaagatgg
    10261 cgtagccaat gcgctggcag aggcagaagg caaagaaatc cgccttatcg acaaagctcc
    10321 ccgcaaaggt gctgaaggtt tgaatatcgc tttccttcac ccgaaatcaa ctttgggtgt
    10381 gttaacagaa ctctgcgaac attaatcata aactctaaaa ctaacaagaa ctcatgagta
    10441 atcaacttga aaaaattaaa gagcttattg aacgccgtgc cgtagcacgt atcggaggcg
    10501 gtgaaaaagc aattgcgaag caacatgaaa aagggaaata cacagcacgc gagcgtctgg
    10561 ctatgctgct tgacgagggt agcttcgaag aaatggacat gttcgttgag cacagatgca
    10621 cgaacttcgg aatggagaaa aaacattatc cgggagacgg tgtggtaacc ggctgcggta
    10681 caatcgaagg acgtctggta tatgtgttcg cacaggactt cactgtttct gccggttcac
    10741 tgtcagaaac aatgtcattg aagatttgta aaattatgga tcaggccatg aagatgggtg
    10801 ctccttgtat cggtatcaac gactcgggtg gtgcacgtat ccaggaaggt atcaacgctt
    10861 tggcaggtta tgcagaaatc ttccaacgca acatccttgc ttcaggtgtt attccgcaga
    10921 tttccggtat cttcggtcct tgtgccggtg gtgctgttta ttctccggct ctgaccgact
    10981 tcacgctgat gatggaaggc acttcttata tgttcctcac cggaccgaaa gtggtgaaga
    11041 ccgttacagg tgaagacgtt agccaggaaa acctcggtgg cgcaagcgtt cactccacta
    11101 aatcgggtgt aactcatttc accgcccaaa cagaagaaga aggtttcgaa ctgattcgca
    11161 aactgttgag ctatattcct caaaacaacc ttgaagaagc tccttatgta gattgcacag
    11221 acccaatcga ccgtctggaa gattctttga acgatattat ccccgacagc cctactaaac
    11281 cgtatgacat gtacgaagtg atcggcgcta ttgtggacaa cggtgaattc cttgaaatcc
    11341 agaaagatta tgcaaagaat atcatcatcg gtttcgcccg cttcaacgga caatcggtag
    11401 gtatcgttgc taatcagcct aagtatctgg ctggtgtgct cgacagcaac gcatctcgta
    11461 aaggcgcacg tttcgttcgt ttctgcgatg cattcaatat tcctatcgta tcgttggtag
    11521 acgtaccggg attccttccg ggaacaggtc aggaatacaa tggcgttatc cttcatggtg
    11581 ctaaactgtt gtatgcttac ggtgaagcta ctgtgcctaa ggttactatc acattgcgta
    11641 aatcttacgg tggttctcac atcgtgatga gctgtaagca acttcgcggt gacatgaact
    11701 acgcatggcc tactgccgaa atcgcagtaa tgggtggtgc aggagcagta gaagtattgt
    11761 acgcacgcga agccaaagat caggaaaacc ctgctcaatt ccttgcagag aaagaagcag
    11821 aatacacgaa actgttcgcc aatccttaca atgcagctaa atatggctac atcgacgatg
    11881 tgattgaacc gcgcaacaca cgtttccgtg ttatccgtgc tttgcagcag ttgcagacta
    11941 agaaattgag taatccggct aagaagcatg gtaatattcc gttgtaatcc tacttttcac
    12001 attaaaacaa gaacgattat gaacaaaacc aaaatcggaa tattcctttc tttgctgttg
    12061 ctgattggtc tgacttcttg tggagagcaa aagtcgaaca ataagctggt gctaaacgaa
    12121 atcctgatag acaatcagag taattttcag gacgattacg gattgcacag cgcatggatt
    12181 gaaatattca ataaatcatt cggtagcgcc gacctggcag cttgcttgct gaaagtaagc
    12241 agccaaccgg gcgatacagt tacttatttt atcccgaaag gtgatatact aaccttagtg
    12301 aaaccacgcc aacatgcact attctgggca gatggcgaac ctaaccgtgg tactttccat
    12361 accagcttca agctgaatcc ggaaacagct aactgggtgg gtctgttcga ctccggcaaa
    12421 aagttgctcg accagattgt agtgcccgca ggcactctcg gtcccaacca atcatacgct
    12481 cgtgtaagcg acggggcagc tgaatgggaa gtaaaaagtg gaagcggtga caaatacgtg
    12541 actccgagca ccaacaacaa gactcttgac agcaattcca agatggaaaa gtttgaagaa
    12601 cacgatgctg atggcgttgg aatgtccatt tctgccatga gcgtagtatt ctgcggattg
    12661 attcttctct ttattgcttt taagattgta ggaaaagtag ctgttaattt gagcaagcgc
    12721 aacgctatga aatctaaagg cattgacaag catgaagcta aggaactgtc acaggctccg
    12781 ggcgaagtat acgctgctat ttctatggca ttacacgaaa tgcaggatga ggtgcacgac
    12841 gtagaagaaa cggtgctgac catcacccgc gtaaaacgca gctactcacc atggagttcg
    12901 aagatttaca ctttgcgtga aactcctccc agaaagtaag tcacctttta aaaagtaaaa
    12961 acgatgaaag aatataaata taaaatcaac ggtaactcat ataaagtaac catcggagat
    13021 attgaagaca acatcgctca tgtagaagtg aacggtacac actataaagt agaaatggag
    13081 aaacagccga agcctgttgc gaaacccgtg acagtacgcc cgatgcctaa tgctcctgct
    13141 gctcctactc aagtagtgaa accgactgct ccatctaccg gaaaatcagg agtaaaatct
    13201 ccgctgccgg gtgtgatcct cgacatcaaa gtgaatgtag gcgatactgt aaagaaagga
    13261 cagaccatta tcatattgga agccatgaag atggaaaaca atatcaatgc ggataaggac
    13321 ggtaagatta ctgccatcaa cgtcaacaag ggagactctg ttcttgaagg taatgacctc
    13381 gtaattattg aataatatgg gagactttat aaacttttta ggaaataacc tggccgactt
    13441 ctggacatac acaggctttg ccaatgctac ggtagggcat gtagtcatga ttctcgttgg
    13501 cttggtattc atctatttgg caatagccaa agagttcgaa ccgatgctgc tgattcctat
    13561 cggtttcggt atattgatcg gtaatatacc ttttaatatg gatgccgggc tgaaagtcgg
    13621 tatttatgaa gaaggttctg tattgaatat attgtatcag ggagtgacct ccggctggta
    13681 tccgccactc atctttttgg gtatcggtgc catgacggac ttctcggcac ttatctctaa
    13741 tccaaaattg atgctgattg gtgcagctgc acagttcggt atcttcggtg catatatgat
    13801 cgcattggaa atgggtttcg acccaatgca agccggtgct atcggtatca ttggtggagc
    13861 agacggcccg acggccatct tcctttcttc caagctagca cctaacctga tgggagccat
    13921 tgcggtgtcc gcctactcct atatggcgtt ggttccggtg atacagccgc ctatcatgcg
    13981 tctgctcacc accaagaacg aacgtgtcat ccgcatgaaa ccgccgcgtg ccgtttctca
    14041 cacggagaag gtgattttcc cgatcatcgg tttgttgctg acttgtttcc tggttccttc
    14101 cggtctgcct ttgctgggta tgctgttctt cggtaacctg ttgaaagaaa gtggtgtaac
    14161 ccgccgtttg gctaatactg ccagtggtcc gttgattgat acaatcacta tcctgttggg
    14221 tctgacagta ggtgcttcta cgcaagcttc cgaattcctg acgctcgact ctatcaagat
    14281 ctttgctctc ggtgcattgt catttgttat tgcaactgcc tccggtgtca tcttcgttaa
    14341 gatcttcaat atcttcctga agaagggtaa taagatcaat ccgttgatcg gtaatgcagg
    14401 tgtttctgct gttcccgact ctgcacgtat ctcacaagtg attggtttgg aatatgattc
    14461 gaccaactat ttgctgatgc acgctatggg tccgaacgtt gccggagtga tcggttcagc
    14521 tgttgctgcc ggtattctgc ttggattctt gatgtaagaa acattatata atagataaga
    14581 acacccgtgt tacattcagt tgtgacacgg gtgttcttta ttacagccat agtgttatct
    14641 tctctccgtt ctgaaacgat taaacgtcat aaaaaaggct gctaccagtg ttcaaaccgg
    14701 agcagcctct ttcttttatt tatggaataa tccggagatt attactgtgc caatttgttg
    14761 tcagaaccga gcacgttgat gattttgtgc ttgtacag
//
