LOCUS       c00472_gnlPro..        14441 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EMOPLLNF_472.
ACCESSION   c00472_gnlPro..
VERSION     c00472_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 13:52:28
            Original ID  :: gnl|Prokka|EMOPLLNF_472
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14441
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14441
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[9466:13678](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      9467..13678
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14441
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14441
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(189..491)
                     /locus_tag="ctg472_1"
                     /transl_table=11
                     /translation="MKKKEENNTGVNQSFKLSVIVGIWESLNLHPTVMIYQSKRKYFLS
                     MLHLSDNGQAKPAVYEIQKEDSRYFIVSAFKRLYISYDAVKDSISLSYYGEYLRN"
     CDS             complement(502..807)
                     /locus_tag="ctg472_2"
                     /transl_table=11
                     /translation="MNIVTIEEQTFKQVCGRFSGFISQVERICKENTHQPEKWLSGREV
                     CALLGISIRSLQNYRDSGKLGYSQIGNKLYYKSADIERLIAECTENKKANYKSNNK"
     CDS             complement(804..1103)
                     /locus_tag="ctg472_3"
                     /transl_table=11
                     /translation="MEEVKQSLQETASKERESYKSVFLKKRSVCNRQSVYISGEIQKRI
                     VQIVGVITNKQVSIGNFIDNVLEEHLGAHNDVLSALYREEIQKGIFNQPKEKDV"
     CDS             1595..2044
                     /locus_tag="ctg472_4"
                     /transl_table=11
                     /translation="MEQKKKPFNKGGRKPKLDPRTHRYSLNLDDVENAKFLAFYDQSGY
                     KVKAHFIKNCIFGKSFKVLRIDKSKVDYYIQLSQLFSQFRSIGILYNQTVKELHSNFAE
                     KKALALLYKLERYTVELVKTNQQIIALTKQFEASYREEGTISAGK"
     CDS             complement(2113..2436)
                     /locus_tag="ctg472_5"
                     /transl_table=11
                     /translation="MYVDSYEFKDWMQKLLDKLEEVGKDVKSLQTNPEVMPNDKLLDNQ
                     DLCLLFKVSTRTLQRLRSKKLLPFMMISGKAYYRASDVREFIKERFDVGTLRKFEKEHG
                     ANK"
     CDS             complement(2469..2612)
                     /locus_tag="ctg472_6"
                     /transl_table=11
                     /translation="MVITICKKEFSVILIITVLQIIYGGLGVPFPHFLCFPFPNFASSI
                     DW"
     CDS             complement(2593..3234)
                     /locus_tag="ctg472_7"
                     /transl_table=11
                     /translation="MPKWDLTEKQIYKLLKHPCQKEKSVIEEITSAYLEFVEDLFDYLN
                     KEHDNKIRIRQLNMSYIDFGTIKALEETSPTENSKLKIIYLDKLLSLINMEQELIYRQM
                     EYPKFFINIESDWKSPFYLNNEVIKIVDIMELVCGIFYIKDGIVRIDNKDIFLSDVARI
                     FEKMFNINFGDIYKKEIAVIKRKPTKITEFLDSLKVAIIKKSRDNGYNHL"
     CDS             complement(3266..3736)
                     /locus_tag="ctg472_8"
                     /transl_table=11
                     /translation="MTRGGKEVVGRRVVVTSEFEANRENIWCKIQDIDTLREICKPKAS
                     FVSYDNTSPTWKEGKSFCFKMFLHGFIPVGKHTINVIKMDKSTGEIVTNEYNKKVTIWN
                     HYINMEEISPNVTRYTDMVDLYAGGLTALAAWWTLKFYKHRQKKWQKIAKNL"
     CDS             3911..4678
                     /locus_tag="ctg472_9"
                     /transl_table=11
                     /translation="MIIEEIEKQIINLLPTSNILLDEVDYSILEERKKDWKKLSEVTHS
                     IVLAFDCYTKKFVFVSDNIPELYGLDSHRLFIDGHQPVVEVIHPDDIYYGLIVRKKIYS
                     ILSSFSNEEKMNYKAIHEMRVRNLRGEYIRIIEQEQVIELDKSGNIWLMLSVIDVDASH
                     ESEIIKSHLYNFKTGEQIFIDLSDTLDEPLTNRELEVLRLMKQGLLSKEIANTLKVSIN
                     TVNTHRQNILQKLKANNSIEAVNFAQRLGLFNK"
     CDS             4700..5062
                     /locus_tag="ctg472_10"
                     /transl_table=11
                     /translation="MENKNVTIVDLFIDILSKNKDTQSQNMVKCLKVFIRIPECAEFLN
                     VIIINAMGYKSQIKSTTVDKAVECIINQSNNRVDEDNSLDEHQKQQIKKDNEIILRMCA
                     DITKNKLKETEQLIED"
     CDS             complement(5465..5887)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_10"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg472_11"
                     /sec_met_domain="Acetyltransf_10 (E-value: 6.5e-19,
                     bitscore: 58.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKIKVTDYPRLMEIWESAVLSTHDFLKEEDFLYYKERLPVYFQ
                     YVNLFGFEQEGILIGFMGIAEGNLEMLFIDNKYRGAGIGKKLITYAIDNLQVTKVDVNE
                     QNVQAVGFYEYMGFNIYKRSNLDGEGKEYPILHMQL"
     CDS             complement(5952..6530)
                     /locus_tag="ctg472_12"
                     /transl_table=11
                     /translation="MLLEKLLKEFNFSTNIFNWEEFKLFDQYFERILVSKGTFLIKEGE
                     TERYSYFVFDGILRCWLLNHNGEEQTFWFCKEGTFSMSNISFTLQTRSAFNVQTIVDSV
                     IYRIDKKQVNELYTAIPKVKTVFEDLNAILLNKLLKRNIDLIKYSPEQYYLQMMEEYGI
                     TLNYIPLKDIASYLGITQQALSRIRKRIF"
     CDS             complement(6636..7199)
                     /locus_tag="ctg472_13"
                     /transl_table=11
                     /translation="MKQIIFIFMSLLCFSCSSKAQNQTADTNVQSDKKILVAYFSCTGT
                     TEKAADAIAKTVGGKLYQITPATAYTSADLDWNNKSSRSSIEMTTENSRPELGGEALNL
                     KDYDMIFLGYPIWWNLCPRPVNTFLEKYDFSGKTVIPFATSGGSSITNSVKQLKKLYPK
                     IVWGESRLLNGSVKQAGEWAKGVI"
     CDS             complement(7428..8255)
                     /locus_tag="ctg472_14"
                     /transl_table=11
                     /translation="MNKLLLFSVFSILTLNVMAQEKIVQTAGRDQLGTFAPKFAELNDD
                     VLFGEVWSRTDKLGLRDRSLVTITSLISMGITDNSLVYHLQSAKKNGITRTEIAEIITH
                     IGFYAGWPKAWAAFNLAKGVWSEDIVGEDAKTAFQREMIFPIGEPNTAYAQYFIGNSYL
                     APVSREQVNISNVTFEPRCRNNWHIHRATKGGGQMLIGVAGRGWYQEEGKPAVEILPGT
                     VIHIPANVKHWHGAAADSWFAHLAFEVSGENTSNEWLEPVTDDEYNKLEQTKR"
     CDS             complement(8267..8704)
                     /locus_tag="ctg472_15"
                     /transl_table=11
                     /translation="MIKTILSVLSLFVMLSCSMTGKKDIKQQPGMCAKLPMAADGIVRL
                     SKIEVYPEYLEEYMKYATEVGEVSLRTEPGVLTMYAVSEKENPGRITILETYASQEAYK
                     SHIASEHFQKYKQGTLHMVKTLVLSDQMPLNPANCINNFIQ"
     CDS             9467..13678
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg472_16"
                     /sec_met_domain="HGD-D (E-value: 6.9e-23, bitscore: 72.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 5.2e-34, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVYKVGLDIGSTTTKMVVLDKDGTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVCREHPHTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLIAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNNDNHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSAPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIR
                     DEVCKNAFSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTS
                     FGCGPDAFLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKNFNYFTPFESIFEKAEKAKQVISPGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
     CDS             13683..14303
                     /locus_tag="ctg472_17"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEE"
ORIGIN
        1 aggaataaag aatgatggag atacaaccat agatggctgc ttaacttgaa aggagataca
       61 gccttttttt tatagtgtac tttatcggat gcttacaatt atctcactgt tgccgtttat
      121 cagttccata ttgttatatc gttttattgg tttataattg gtttaaatga tgacaggcac
      181 acaccttgtc agttacgcag atactcgcca tagtaagata aggaaatact atctttgacc
      241 gcatcatagc ttatataaag ccgtttaaag gctgaaacga tgaagtaacg gctatcttct
      301 ttctgtatct cgtaaacggc tggttttgcc tgtccgttat ccgataaatg gagcatcgaa
      361 aggaaatact ttctcttgct ttggtatatc atcaccgtag gatgaagatt taaactttcc
      421 catattccga caataacaga caatttgaat gactggttta ctcctgtatt attttcttct
      481 ttctttttca tagggcaata tttatttatt gtttgattta taattcgctt tcttgttttc
      541 cgtacattct gcaatcagtc tttcaatatc ggcagattta tagtacagtt tattaccgat
      601 ttgggagtaa cccaatttgc cactgtcccg gtagttctgc aaacttcgga tgctgatacc
      661 gagcagggcg cacacttcac gacctgacaa ccatttctcc ggctggtggg tattctcttt
      721 acaaatccgt tccacctgac tgatgaaacc ggagaaccgc ccacatactt gtttaaaagt
      781 ctgttcctca atagttacga tattcatacg tctttttctt ttggctggtt gaatattcct
      841 ttttgtattt cttcccggta gagagccgaa aggacatcat tgtgcgcacc taaatgttct
      901 tccagtacgt tatcaatgaa atttccgatg cttacttgtt tgtttgtaat cacgcctaca
      961 atctgaacga tacgtttttg tatctctccg cttatgtaca cgctttgacg gttgcaaacc
     1021 gaccgttttt taaggaacac cgatttataa ctttcccgtt ccttacttgc tgtttcctgt
     1081 aatgattgtt ttacttcttc catacattta atttttaatg atttataaat aagttgattg
     1141 attcccgata ctgattgaaa aaatgcaagc cagttttata actatgtccc tttatcttta
     1201 aatagctttc aaacatggtt taaaactata ttcagacctt gttttactgt cttatatatt
     1261 gccaccactc aatcattttt cagcaaagaa agaggtaaaa acaaacgctt ttaaaaatgg
     1321 ggttactttg tctgtttatg tcacaatttg gcgcaaccgc ctatatttcg ggagggaatt
     1381 actgtctgta attttgcaac tgataaacag acagaggata aagccaaacc gcttgctttt
     1441 gcaatctgac tatagggaag atttttgtta tcacatgata acagcaagtt gtgttttgag
     1501 gcccgcgctt cgctttttgt gcctcaaaac cttgccacct tttaaggtgg ttggttttac
     1561 tccgaagtcg taaaatcagt aaataattat cattatggaa cagaaaaaga agccatttaa
     1621 caaaggtggg cgcaagccta aacttgaccc acgaacacac cgctattctc ttaatttaga
     1681 cgatgtggag aacgctaagt tcttagcctt ttacgaccaa tcaggctaca aggtaaaggc
     1741 gcatttcatt aagaactgta ttttcgggaa atcgtttaag gtgcttagaa ttgataaaag
     1801 caaggtagat tattacatcc aactctccca attgttttca caattcagga gcataggcat
     1861 actgtataac caaacggtga aagaactcca ttccaatttt gcggaaaaga aagcacttgc
     1921 cttgctttac aaactggaac gatatactgt tgaactggta aagacgaacc agcagattat
     1981 tgcgcttacc aaacagtttg aagcatctta tagggaagag ggaacaatat cagcagggaa
     2041 gtaaatacag acttgccaaa agaaaaacat cccgaaactg ccacgtgtac agctccggga
     2101 tgaatttcac tcttacttat tcgctccgtg ttctttctcg aactttcgga gcgtgcccac
     2161 atcgaaccgt tcctttatga actcacgcac atcggaagcc cggtagtagg cttttccgct
     2221 aatcatcata aagggtagca gttttttgct tcttaatctc tgtaatgtcc gggtactgac
     2281 tttgaacagc aggcataaat cctgattatc caaaagtttg tcattcggca ttacttctgg
     2341 gttggtttgc aaactcttta catctttgcc gacttcttcc agtttatcaa gtagcttttg
     2401 catccagtct ttgaactcgt aactatctac atacatattg cttcattttt cagtttatac
     2461 actaatgctt accaatcgat tgatgaagca aagttcggaa aagggaagca aagaaaatgg
     2521 gggaatggta cacctaatcc cccataaata atttgtagta cggtgattat caatataaca
     2581 gaaaattcct ttttacaaat ggttataacc attatctctg ctctttttta taatagcgac
     2641 tttcaagcta tctaaaaatt ctgttatttt agtaggtttc cttttgataa ccgcaatttc
     2701 ttttttgtat atatctccaa aattaatgtt gaacatcttt tcaaaaatcc gggcaacatc
     2761 acttaaaaat atgtccttgt tatcaatccg aactattcca tctttgatgt aaaaaatacc
     2821 acaaaccaat tccattatat ctacaatttt aataacctca ttgtttaagt agaatggaga
     2881 tttccaatca gattctatat tgatgaaaaa ttttggatat tccatttggc gatagattag
     2941 ttcttgttcc atatttatta aagacaagag tttatcaaga tatataattt tcagtttact
     3001 attttcagta ggagaagttt cttctaatgc ttttattgtt ccaaaatcta tataactcat
     3061 atttaattgc ctgatacgta ttttattatc gtgctcttta ttgagataat cgaataaatc
     3121 ttcaacaaat tcaagatatg cagaagttat ttcttctatc acagattttt ccttttggca
     3181 aggatgcttt agcaatttat atatttgctt ttctgttaaa tcccattttg gcataatctt
     3241 tcttagaaga aaaagtgtaa ttgttttata agttttttgc tatcttctgc cattttttct
     3301 gcctatgttt ataaaattta agcgtccacc aagcggcaag agctgttaaa ccacctgcat
     3361 ataaatcaac catatctgta tatcttgtta cattaggaga aatttcttcc atgttgatat
     3421 aatgattcca tatagttact tttttattat actcatttgt tactatctct cctgtgcttt
     3481 tatccatttt gattacgttt attgtatgtt ttcctactgg aataaatcca tgtaggaaca
     3541 ttttaaagca aaaagatttc ccttctttcc aagtaggaga agtattatca taagatacaa
     3601 aactggcttt tggcttgcaa atttctctta aggtatcaat atcctgaatt ttacaccaaa
     3661 tattttccct gttagcttca aactcagaag taacaactac tctacgtcct acaacctctt
     3721 ttccgccacg tgtcattaaa caaattttct ttatcatact acatgaatta aaatattaaa
     3781 catctattta tcttatactt atactgattt cattatcttt gtgcaaagat agaagcaata
     3841 gactctaaag gcaatagtca tttataatga gagaacgtgc aaatatctaa taatcagata
     3901 tttttaaaat atgataattg aggaaattga gaagcaaata ataaacttac tcccgacatc
     3961 aaacatacta cttgatgagg tagactattc cattctcgaa gaaaggaaaa aggactggaa
     4021 aaaactctcg gaagttacgc acagtattgt gttggcgttt gattgctaca ctaaaaaatt
     4081 tgtatttgtt tctgataaca ttcctgaatt atatgggctt gattcccata gattgtttat
     4141 agacgggcat cagccagtag tagaggttat acatccagat gatatatact acggattaat
     4201 tgtaagaaag aaaatctatt cgatattgag ttcgttctcc aatgaagaaa aaatgaacta
     4261 taaagccatt catgaaatgc gggtgaggaa tctacgaggt gaatatatcc gtataataga
     4321 gcaggaacag gtcattgagt tggataaatc aggcaatatt tggcttatgc tgtcggttat
     4381 tgatgttgac gcaagccatg aatcagaaat tattaaaagc cacctatata actttaaaac
     4441 tggagaacag atttttatag atttatctga tacattggat gaacctttaa caaatagaga
     4501 gttggaggtt ttgcgtttga tgaagcaagg cttgttaagt aaagagatag caaacacttt
     4561 gaaagttagc atcaatacgg tgaatactca tagacaaaat atattgcaaa agctaaaagc
     4621 caataattcg attgaggctg taaattttgc tcaaaggtta ggtttgttca ataagtaaat
     4681 atcatataat agtaataaaa tggaaaataa aaatgttaca atagtagatt tgtttataga
     4741 tattctgtct aaaaataaag atacacaatc gcaaaacatg gtaaaatgtt taaaagtttt
     4801 cattcgcatt cctgaatgcg ctgaattttt aaatgttatt attattaatg caatgggata
     4861 taaatctcaa ataaaatcta caacggtaga taaagctgtt gaatgtataa ttaatcagtc
     4921 taataataga gtagatgaag ataattccct tgatgaacat caaaaacagc aaattaagaa
     4981 agataatgaa atcatattaa gaatgtgtgc agacatcacc aagaataagt taaaggaaac
     5041 tgaacaactt attgaagatt aatttgccta aaagcagaaa tacattctaa atattactat
     5101 ctttgcacca actcaaacaa ccaccgcaac accaagcaat ctaaagaatt gcgcacgtgg
     5161 ggttattagt gggagaaaga ttttagagat tgctaagata ttgagtatgt gaagaataaa
     5221 actaaggttc atcttccgta cgcaccgcga aagcaaatag taaattaaag caaagctctg
     5281 aaattcaaga aattcagagc ttttttcttt ttcttcactt catttaaaac agagtttaag
     5341 taggcgatag atgtgcccat tcaaactcta caatgatttt ttaaccaatc attttattca
     5401 aatgtaacat tcatcttcaa ttaaaggtac ctatactaag catctgttta taattgaaca
     5461 gagactacaa ctgcatgtgt aaaataggat attccttacc ttctccgtcc aaattcgacc
     5521 ttttatatat gttaaaaccc atatattcat aaaaaccgac agcttgaaca ttttgctcat
     5581 tcacatcaac tttagttact tgcaaattat ctatggcata agttattaat ttttttccga
     5641 ttcctgcgcc tcgatactta ttgtcaataa ataacatttc aagatttcct tctgcaattc
     5701 ccataaatcc gattaagatt ccctcttgtt caaatccgaa tagattaaca tactgaaaat
     5761 ataccggaag tcgttcctta taatatagaa aatcttcctc tttaagaaaa tcatgtgtac
     5821 tcaatactgc actttcccaa atttccatca aacgtggata atccgtaact ttaatttttc
     5881 taatcatact tgtaattgca atttaaagcc gcaaagttcg ttacttatac attcaaaaca
     5941 ctgaacctaa gttaaaaaat acgtttacgg attctgctta gtgcttgctg tgtgataccc
     6001 aaataagaag ctatatcttt taatggtata tagtttaatg taataccata ttcttccatc
     6061 atctgtagat aatactgttc aggagaatat ttaatcaagt cgatatttct tttcaaaagt
     6121 ttattcaaca atatagcatt taaatcttca aatacagttt ttactttagg gatagcggta
     6181 tatagttcat ttacttgctt cttgtctatt cggtaaataa cactatctac aattgtttgc
     6241 acattaaatg cagacctagt ttgtaatgta aaagatatgt ttgacattga aaacgtaccc
     6301 tctttacaaa accagaaagt ttgttcttcc ccgttatgat ttaaaagcca acaacgtaat
     6361 attccatcaa aaacgaaata actatacctc tctgtttctc cttccttaat caaaaatgta
     6421 cctttactaa ctaatattcg ttcaaaatat tggtcgaata acttaaactc ctcccaatta
     6481 aaaatattag tactaaaatt aaattcttta agtagttttt ctaaaagcat aatctaaata
     6541 tgattcgtaa tatacttact catttaatat attcactatt acttccgccc tatttaactt
     6601 ctcatattta gtgaatatat tttcagtagc catttttata ttactccttt cgcccactct
     6661 ccggcctgct tgacacttcc gttcaacaat cggctttctc cccatacgat ttttggataa
     6721 agtttcttga gttgttttac actattagtt attgagcttc ctccggaagt agcaaatgga
     6781 ataacggttt taccggagaa atcatatttc tcaaggaatg tattgaccgg acgcggacat
     6841 aaattccacc atatcgggta accaaggaat atcatgtcgt aatctttcag attaagcgct
     6901 tctcccccca attccggacg tgaattttca gtcgtcattt caattgaact acggctactc
     6961 ttgttgttcc agtcgagatc tgccgaggta taggctgtag cgggagttat ctgataaagt
     7021 ttgccgccaa ccgtttttgc aatggcatcg gcggcttttt ctgtagttcc agtacaagag
     7081 aaataggcaa ccaggatttt cttatcggac tgtacattag tatccgctgt ctgattctgc
     7141 gcttttgatg agcagctaaa gcaaaggaga ctcataaata tgaatataat ctgtttcatt
     7201 ttattttgat tttaaatatt tcttatcatt aattagttta gacattatca cgatggagta
     7261 accccacagg cgttttcatt cttccattac tttgataatt gcccatatcg tccatcaaac
     7321 gatgtatttc ttctgtatta agcgctttgc gcgtctttac atattcctta aaattcctcg
     7381 gtagtcatat tatttccttt caaaagataa agcaggatta gcaaaaatca tcgtttagtc
     7441 tgttcgagtt tgttatactc gtcatctgtg accggctcaa gccactcatt ggaagtgttt
     7501 tcaccggaaa cttcgaaagc cagatgagca aaccaactgt cggcagcagc tccgtgccag
     7561 tgtttcacat tggcaggaat atggataacc gtaccaggca gaatctctac cgccggttta
     7621 ccttcttcct gataccagcc tcgaccggct acaccgataa gcatctgtcc gccacctttc
     7681 gttgcacggt gaatatgcca gttattgcgg caacgtggtt caaaagtaac gttagagata
     7741 ttcacctgct cgcgcgaaac cggagcaaga taactgttac caataaaata ctgtgcatag
     7801 gctgtattgg gttcgccaat agggaaaatc atctcacgct ggaaagctgt tttggcatcc
     7861 tcaccaacaa tatcttcaga ccatactcct tttgccaaat tgaacgctgc ccacgctttc
     7921 ggccaacctg catagaaacc tatatgagtg ataatctctg cgatctccgt gcgggtgatg
     7981 ccgttcttct tcgccgactg aagatgataa acgagcgaat tgtccgtgat tcccatactg
     8041 ataagggagg taatggttac taaactgcgg tcacgcagac cgagtttgtc agtgcggctc
     8101 caaacttctc caaagagaac atcgtcatta agttccgcaa acttgggggc aaacgttcct
     8161 aactggtcgc gtcctgccgt ctgtactatc ttttcttgtg ccataacatt gagtgttaaa
     8221 atactaaata ctgaaaataa aaggagttta ttcataatca tttcgtttat tgaatgaagt
     8281 tattaatgca atttgcgggg ttaagcggca tttggtcaga gagtacgaga gtcttaacca
     8341 tgtgcagcgt tccttgcttg tacttttgaa aatgctccga tgcaatatga gatttataag
     8401 cctcctgact cgcgtaagtt tcaagaatag ttatcctgcc aggattctct ttttcgctga
     8461 cggcatacat agtcagcact cccggttcag tacgcaagga gacttcaccc acttcggtcg
     8521 catatttcat atattcttca agatactccg gataaacctc gattttcgat agccgcacaa
     8581 taccgtcagc cgccataggt aatttggcgc acataccagg ctgctgtttt atatcctttt
     8641 tccctgtcat actgcatgat aacataacga ataaagacaa aacacttaga attgttttta
     8701 tcatcatctt ctatcttttc attgttaaac ttctgattgc aaatttactg cgataaaacg
     8761 aatggaattg tatatcaatt acggattttt gtacccaaat ccccgattct gtaataaagc
     8821 cgaataaaaa tcagatatta gaagtaaagt tattcatctg ttttgagacc gataagctac
     8881 ttttctcatc agactcttga caaatgactt tttatgttgt atctttgaga aaagaaaaag
     8941 tataaacaac atgaaaatag aaagaaataa tcatacataa atcataaata acctggtatt
     9001 ttacaatacc actcctatac gatatggggc aatagtcgaa tgattattgc cccattttgt
     9061 ttataattca gcttaaaatc tctcgtctga tcctagaact gttctacaat agtttataat
     9121 aaactcgaat accgttttac taaaactatc aaaaagttta ttataaacag aatccgggtt
     9181 tattaaaagc cacgttacct tttgtcaaaa atagagtaaa caagatttct aagattcacc
     9241 ataaaagatc tactacaacc caacaagtaa tataaataca caattattca tttacgtctt
     9301 tttttacacg atcgttttcc tccctcacat tccatctttc ttttttccca attcgttaat
     9361 taaatcaaaa acttcaatta cgatttgccg tatctaccat atttttacat acatttgcgt
     9421 ctgacacaga tgtcaaacac gaggtctaat ttaagatatt tggtatatga atgtatataa
     9481 agtgggttta gatataggct ctactaccac taagatggta gtattggata aagatggaac
     9541 tacagtcttg ttttccggat acaaaaggca tcaggcaaaa atacaagaat gtttactcgg
     9601 atttctttat caaataaagg aacagttggg tgatattcct ttatctttcc acattacggg
     9661 ctctgttgga atgggaattt cagagaaatg ctctctgccg tttgtgcaag aggttgtagc
     9721 tgcaacaaac tatgtgtgcc gggagcatcc gcacacagcc actatgatcg atattggagg
     9781 agaagatgcg aaagttgttt tctttcagga cggacaggct acagacctgc gcatgaatgg
     9841 aaattgcgcc ggcggaaccg gggctttcat tgaccagatg gctattctgc ttggagtctc
     9901 catcgacgaa ttgaatgaac tagcacttcg ttccaatcag gtatactcta tcgcttcacg
     9961 ctgcggagta ttctgcaaaa cggacataca gaatctgata gccaaaaata tatctaaaga
    10021 aaatatagca gcttccattt tccatgcagt agccgtacag accactgtca cacttgcacg
    10081 cggttgcaat atcgtagctc cggtattact ctgcggtggc ccattgactt ttattccggc
    10141 ccttcgaaaa gcatttgcca actatctgaa tctgtcacaa gatacagatt tcatattacc
    10201 ggaaaaagga aatctgatcc ctgcctgggg agcagcattg gcagagaaca atgaagaaag
    10261 tattcatctc tccaacctga tacaggtaat agaaaacaaa ctaagtgtta cctcaccttt
    10321 ccagagtgat ctttctccta tattcgacag tgaggaagaa tatcggtcat ggaaaaaaga
    10381 aaaagaccag tataaaattc aatatgccag tctgcgtccc ggattacagg aagcaactat
    10441 cggcatagac tccggctcta ctaccaccaa aatcgtagta ctcgacaaca atcatcgtat
    10501 cctttactcc tattatcacg acaacaacgg aaaccctata aaaacagtag agaacggctt
    10561 gcagaaacta tatgaagaat gccggagacg aggaactacc ctgcgcataa aaggaggatg
    10621 ttctaccggt tacggagaag atctgataaa agcggctttc cacatggatg cgggaatcat
    10681 tgaaaccatc gctcattatg ctgctgccaa acatatcagc aaagaagttt cttttatcct
    10741 ggatattgga gggcaggata tgaaagccat ctttgtgaac gacggagtaa tcaacagaat
    10801 cgaaatcaat gaagcctgtt cctccggttg cggttctttt atcagcacat ttgcgcaatc
    10861 gctggattac agtgtggagg actttgccaa agcagcttgt ttttcgcaag caccatgtga
    10921 tctgggtaca cgttgcacag tcttcatgaa ctccaaagta aaacaggtac ttcgggaagg
    10981 agcgtccgta gcggatatag ctgccggatt atcttattcc gttgttaaaa actgcctgta
    11041 taaggttctg caattaaaag acacggagat acttggcgac catattgtcg tgcagggagg
    11101 aaccatgcgt aatgattcca tcgtacgaag tctggaaaag ctgaccggga aacaaacctt
    11161 ccgcagtaac tgtcctgaat tgatgggtgc tcttggttgt gccctatatg ccaaacaaat
    11221 cgaaaatgcc cgggtgacgg agctgaacga gatgctccaa tgggcgcaat atacttccaa
    11281 gcaacttcaa tgccgggggt gcgagaacca gtgcgccatt atgcgatata cgttcaacaa
    11341 tgacaaccat tacttctccg gcaaccgatg tgaaaaggta ttttccaata aaggaagcca
    11401 tgcggacaaa ggcatcaata cgtatgataa aaagctggaa ttattattcg accggagcgc
    11461 agacattcca caacccctat ttaccatagg cattccacgt attctgaata tgtatgagga
    11521 ataccctttc tggcatacct tatttactgc ttgcggcatt caggtacagt tgtcggcccc
    11581 ctctacattc agcaaatacg agactgctgc cggcatggtg atgtctgata acatctgctt
    11641 ccctgccaaa cttgtgcaca gtcatatccg taacctgaca ctgcaaaacg tcaaccggat
    11701 atttatgccg ttcgttgttt tcgagaaaaa ggataagcaa cagcaaaaca gctataattg
    11761 ccccatcgtt tccggttatt cggaagtcat caaaagtgta caggaagaga atataccgat
    11821 agatgctccg actatcacct tcaaagatga agcattgctg tataaacaat gctatgaata
    11881 tctgaaatct ttgggtatca gggatgaggt atgcaaaaat gccttctcac gcgcattaca
    11941 ggaacaatat gctttcgaag aaaaaattgc tgcctataat caggaagttc tgaacgaggg
    12001 acgggaaaaa cacaaactga ttatcttact cgccggacgc ccttaccata gcgatccact
    12061 gatacagcac aaggtttcgg acatgattgc tgcgatggga gtttatgtga taactgatga
    12121 tattgtccgc cagcaggaga tttcattgga aaagactcat tacctctctc aatgggcatt
    12181 taccaaccgt attctgaaag caaccaagtg ggcggcaatg caagagggtg acatacaata
    12241 tatgcagatg acttcttttg gctgcggtcc ggatgctttc cttatagatg aagtacgtaa
    12301 cttgctgaaa cgatacggca agaatcttac tttgctcaag atagacgatg ttaataatat
    12361 cggctccatc aaattacgag tccgctcgtt ggtggaaagc ttgaatttca gtttgaaaca
    12421 ttctcaagcg aaagatcccg agccatttgt ttcaactgct cctttcacca agaaagacaa
    12481 aaagaagaaa atcctcgctc cattctttac gcctttcatt tcaccactca ttccatccat
    12541 catgaaagtg gccggatatg aaatggaaac gttaccgttg agcgacaccg catcttgcga
    12601 ctggggattg aaatactcca ataatgaggt atgttatccg gcaacattga ttgtcggcga
    12661 catagtaaaa gcctttaaaa gcggacgtta tgatcctgcc aatacgtgcg ttgccatcac
    12721 acaaaccggt ggacaatgtc gtgccagcaa ctatatttca ctgataaaaa aggcattgat
    12781 tgagaatgga tacaccaata caccggtggt atcacttgct ttcggcagtg gtattgaaaa
    12841 tgagcaatcc ggttttaaag taaactggct caaggttttg ccaatcatac ttgcgtctgt
    12901 gttatacagt gattgtatcg ctaaattcta ttatgcagcc gtcgttcgtg agaaagaacg
    12961 gggacaggcc gcccgtctgc gcgatcttta tctggataca gcacagccca tcatccagaa
    13021 aaataaaccg gaggacttgt tgagttactt atatctcgct gccagagact tcaacaaaat
    13081 ctgtgaacag agatcctgtc acaaagtagg tattgttgga gaaatattcc tgaagttcaa
    13141 cccttttgct caaaaggacg tcacctcatg gctcatcaac cagaagatcg aagtgattcc
    13201 gccactgata agtgatttct tcatgcaggg atttgtcaac ctgaaagtga gacagaacca
    13261 acacttgcag cgaaaactca ctcccgactt tgttatcgac tggttataca agaaagtcca
    13321 gaagcagatt aataaagtga atgaaatcgg caaaaatttc aattacttca cgccgttcga
    13381 atcaatcttt gaaaaggcag aaaaagctaa acaagtcatc tccccgggca cccagtttgg
    13441 agagggttgg ctgatatccg gtgaaatact atcctttgct tcccaaggag tcaatcatgt
    13501 cattagcttg caacctttcg gatgcattgc caatcacatt gtagaaaaag gaatagaaaa
    13561 acgtataaaa tcgctgtgcc ctcaaatgaa tatactatct ttagactttg acagtagcgt
    13621 cagcgatgtg aacataacaa acagattatt actttttatt gacaacataa acaactaaaa
    13681 ttatggctac aacggaacat agcgatttag agcagcaaat aataaaaact gcccaacaac
    13741 tttttataga aaaaggattt gtggagacca gcatgagtga tattgctgca acggtaggaa
    13801 tcaaccggcc cactttacat tattatttca gaaccaaaga taagatgttc aaagccgtgt
    13861 tcggctcgat agtcatgtct ttaatgccga aaatacagga tatagtaaaa caggatatcc
    13921 catttatgga gcgactaagc atgattctgg atgagtatat tgagcttttc acaagtaatc
    13981 cctgtcttcc cagattcatt tgcggagaaa tacagcgtga tgtaaaccac ttgcttgcca
    14041 ctgcaaaaga acttcagttc ggagatgctt tatcccaagt gaaagacagt atactgacag
    14101 caatggaaga cggtaaactt aaaaaggttc cgatacatat tgtatttctg actgtctaca
    14161 gcctattgag ctatccattt cttgccaaga acctgatagt atctttattc ttggaagatg
    14221 aagccgcttt tgctgacttc ctgcaagaat ggaaacaaaa catcatcaac caattgcaga
    14281 acttattgtg ttatgaggaa tagtatagat actatataag gaggtgtgtc ataatgaata
    14341 ataaaacgca gattaacgca aattatcgca gattattcca attatattga tatattaatc
    14401 aacgacttat aaaattattt ctgcgataat ttgcgttaat c
//
