LOCUS       c00835_gnlPro..        12941 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KEKHGNPL_835.
ACCESSION   c00835_gnlPro..
VERSION     c00835_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 10:48:49
            Original ID  :: gnl|Prokka|KEKHGNPL_835
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12941
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12941
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[8009:12941]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      8010..12941
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..12941
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12941
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(2..1222)
                     /locus_tag="ctg835_1"
                     /transl_table=11
                     /translation="MEEKELWMNKLKEKLADYSEPVPASAWEQLEKELMPPVEKKIYPY
                     RKWMMAAAAVILLAVVSSVSLYFLGTPAADEIRHIKTPALASTPDALPGVQQPDVQGTS
                     VEPVLRPVAREDRLAKIDKNLTEQKTNAGQSAIENNNEPVTGNENNPVIEEDQMLKGET
                     EQTKNEARQVDSENVGQATQSQDTERPNNRPRRPSGRDKLHIPAEKRASQKGTWSMGLS
                     VGNSGGASTEVGAGSHAYMSRVSMLSVSNGLMEIPNDQTLVFEDGVPYLRQAKQVVDIK
                     HHQPISFGLSVRKGLAKGFSLETGLTYTLLSSDAKLAGEDQQIEQKLHYVGIPLRANWN
                     FLDKKLVTLYVSGGGMVEKCVYGKLGSEKETVKPLQFSVSGAVGAQVNATKRLGIYVEP
                     GVAYYFDD"
     CDS             complement(1229..1777)
                     /locus_tag="ctg835_2"
                     /transl_table=11
                     /translation="MEELELSEQCRLGNNQARKELYEQYAGRMLGICLRYTGDRDTAQD
                     LLHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQYLRKNDVINQSAPLEELPEEY
                     EEPDASDVEAIPQKVLMQFIEELPAGYRTVFNLYTFEDKSHKEIAQELGINEKSSASQL
                     FRAKSVLAKRVKEWITHNG"
     CDS             1954..2676
                     /locus_tag="ctg835_3"
                     /transl_table=11
                     /translation="MKKFKFIAFIFAIMTTMPILQSCLDDDDNPSDLLVVSTINMISQD
                     SKEFYFTLDDGKKMYPSNAQGWSNKDWVEGQRAFVIFNELEEPVNGYDLNIQVRGINPI
                     LTKDIITMGEDDNDEEKVGDDKINTTYMWINKDNKYLTIEFQYYGTHSEDKKHFLNLVI
                     NDKEESAPTADEDSAEDEYINLEFRHNSEGDYPQSLGEGYVSFKLDKIKDRMEGKKGLR
                     IRVNTLYGGPKTYEVKFP"
     CDS             complement(2809..3489)
                     /locus_tag="ctg835_4"
                     /transl_table=11
                     /translation="MKKYIAEMIGTMVLVLMGCGSAVFAGSVTGTVGAGVGTVGVALAF
                     GLSVVAMAYAIGGISGCHINPAITLGVFLTGRMNGKDAGMYMIFQVIGAIIGSAILFAL
                     VSTGAHDGPTATGSNGFGDGEMLQAFIAEAVFTFIFVLVVLGSTDSKKGAGNLAGLAIG
                     LTLVLVHIVCIPITGTSVNPARSIAPALFQGGEALSQLWLFIIAPFVGAALSAVVWNYL
                     GDKK"
     CDS             3607..3777
                     /locus_tag="ctg835_5"
                     /transl_table=11
                     /translation="MKKGLLHAILASTLWAIVNSLIKQGLSNDVTPMNFSETRFATVGV
                     ILFAYTRYKGI"
     CDS             complement(3802..4728)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     61.1; E-value: 2.4e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg835_6"
                     /sec_met_domain="LysR_substrate (E-value: 1.7e-44,
                     bitscore: 141.4, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 5.1e-20, bitscore: 61.1,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQQLEYILAVDQFRHFARAAEYCRVTQPTLSAMIQKLEDELGV
                     KLFDRTVQPVCPTPIGQKVIDQARVILAQAAQVKEIISEDKQSLSGVFRLGVLPTIAPY
                     LLPRFFPQLMEKYPELDIRVTEMKTQDIQQALHAGDLDAGIIASKLEDTFLTGETLFYE
                     QFYAYVSRKEPSFKHDVIRTSDITGEHLWLLDEGHCFRDQLVRFCQMEAVKVSQMAYRL
                     GSMETFMRMVESGKGITFIPELAVAQLTEEQRQLVRPFAIPRPTRQVVLATNRDFIRHS
                     LLCVLKEEIKAAVPKEMLTLQSIQCLL"
     CDS             4867..5343
                     /locus_tag="ctg835_7"
                     /transl_table=11
                     /translation="MKTLEFIKLNESGANNVVASLQQLLADFQVYYTNLRGFHWNIKGH
                     DFFVLHSQFEKMYDDTAEKVDEIAERILMLGGTPANKFSDYLKVANISEVDKVSNGEQA
                     LNNILQSISYLIGEERKILSIASQAGDEVTVSMMSDYLKEQEKLVWMLTAYNSK"
     CDS             complement(5654..6790)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 57.1; E-value: 4e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg835_8"
                     /sec_met_domain="AMP-binding (E-value: 8.4e-19, bitscore:
                     57.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRKQQRLLLEGKEYTFEDISRLIAGGAEAHSPASWDLYLFLN
                     EWFNDSPVIIVHTSGSTGTPKELIVRKDQMMQSARLTCEFLDLKKGETALLCMNLRYIG
                     AMMVVVRSLVAGLNLIVRPASGHPLADIKEPLRFVAMVPLQVYNTLQVPEEKERLKQTD
                     ILIIGGGAIDEALEAEIKHLPTAVYSTYGMTETLSHIALRRLNGTLASEHYYPFSSVKL
                     SLSVENTLIIDAPLVCDEILQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKL
                     LRSFIPVPFVITSVPDQRLGQAVTLLLEGQPELLEGQPDTKEIGNKLQEILEPYYRPKY
                     IWTTDCIPQTENGKVNRAKCRILAKQMLTTFYTHTLTP"
     CDS             complement(6812..7837)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg835_9"
                     /sec_met_domain="MR_MLE_C (E-value: 2.2e-28, bitscore:
                     89.1, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCKIEIIPRLLHFKQPAGTSRGTYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILVKVCRKVEREQGRLDMDGLCDYPSILFGLETAIRHFF
                     AGNWALCDTAFSRGEVGIPINGLIWMGDFQNMLSQIEKKMEAGFRCIKLKIGAINFEEE
                     LTLLRHIRTHFSSKEIELRVDANGAFSPVDAMEKLKRLSEFDLHSIEQPICAGQWEEMA
                     RLAAESPLAIALDEELIGCNTLERKQELLSTIRPQYIVIKPSLHGGICGGDEWITEAEK
                     QQIGWWITSALESNIGLNAIAQWCATFSNPLPQGLGTGALFTDNVEVPLEIRKDCLWFC
                     K"
     CDS             complement(8010..8834)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg835_10"
                     /sec_met_domain="ECH_1 (E-value: 1.2e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(8838..10505)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg835_11"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-07, bitscore:
                     21.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYPVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVIISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDSLPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKVGQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPEYPRVWENYCKIIPEPEFAYSEMSAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTNGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNVNVRSNLRV
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELAEAM
                     KTFTQPEAMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(10525..11640)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg835_12"
                     /sec_met_domain="Chorismate_bind (E-value: 5.4e-58,
                     bitscore: 186.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSESCPVVLIQPDQWGQPLPVDDDTEEDREIALRLQGQES
                     FLTSSTEEYAACFHTFINALRDRTFDKLVLSRHLTVDKVADFSPLSIFRAACKRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLDIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             complement(11637..12941)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg835_13"
                     /sec_met_domain="HBT (E-value: 2.2e-18, bitscore: 56.3,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="FYLFTLSVVHSISYLCNLNQNRVIMKYKLLVLDVDGTLLNDAKEI
                     SKRTLAALLKVQQMGVRIVLASGRPTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNG
                     EILFERRINPEMLPYLEKKARKNGFALFTYHDDTIITDSPENEHIQNEARLNNLQIIKE
                     EEFSAAVDFAPCKCMLVSDDEEALVGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKA
                     NSLGALLEVLDVKREEVIAVGDGVCDVTMIQLAGLGVAMGHSQDSVKACADYVTASNEE
                     DGVAVAVEKAIIAEVRAAEIPLDQLNAQARHALMGNLGIQYTYADEDRVEATMPVDHRT
                     RQPFGILHGGATLALAETVAGLGSMILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTV
                     VHKGRSSHVWNVDVFTSTNKLVSSIRVVNSVMKKR"
ORIGIN
        1 cgtcatcaaa ataataagca acaccgggtt ctacatagat acccagacgt ttcgttgcgt
       61 tcacctgtgc acctaccgca ccggataccg agaattgcag aggtttcacc gtttctttct
      121 cggaaccgag ctttccatag acacatttct ccaccatacc tccaccggag acgtagagag
      181 tgacgagttt cttatcaagg aaattccagt tggcacgcag cggaataccg acataatgaa
      241 gtttttgttc tatctgctga tcttcacccg ccagtttcgc atccgaagaa agcaatgtgt
      301 aagtcaatcc cgtttcgaga gagaatcctt tggccagtcc tttacggacg gacaatccga
      361 aggaaattgg ttgatggtgc ttaatgtcga ccacttgttt tgcctgacgc aaataaggca
      421 ctccatcttc aaaaaccaat gtctgatcgt taggtatctc catcagaccg ttggaaacag
      481 aaagcatact cacacgagac atataagcat gagagccggc accgacttct gtggatgctc
      541 cgcccgaatt tccgaccgag agtcccatgg accatgttcc tttttgagat gctctttttt
      601 ctgccggaat atgcagcttg tctctgccgg aagggcgacg cggcctgttg ttcggccgtt
      661 cggtgtcctg tgactgtgta gcctgaccca cattttcact gtcaacctgc cttgcttcat
      721 ttttcgtctg ttccgtctca cctttgagca tctggtcttc ctcaatcaca ggattatttt
      781 cattccctgt tactggttcg ttgttatttt ctattgcaga ttggcctgca tttgttttct
      841 gttctgtaag attcttatca attttcgcca aacggtcttc acgagccact ggtcgcaaga
      901 cgggttctac ggaagtgccc tgcacatccg gttgttgcac acccggcaac gcatcgggtg
      961 tagatgccaa tgccggagtc tttatatgac gtatttcatc cgcggccggt gtccccagaa
     1021 aatatagact taccgacgaa acgacggcta acaatataac agctgcagca gccatcatcc
     1081 attttcgata aggatatatt ttcttctcca caggaggcat aagttctttc tccagttgtt
     1141 cccaagcgga agcaggcacc ggctcggaat aatccgcgag cttctccttc aacttattca
     1201 tccacaattc tttctcttcc atctctatct atccattatg cgttatccat tcttttactc
     1261 tttttgccaa tacactcttc gcacgaaata gttgcgaagc cgaagatttt tcattaatac
     1321 ctaattcctg tgcgatttct ttatgcgatt tgtcttcgaa tgtataaagg ttaaacactg
     1381 tacgatatcc ggcaggtagt tcttctataa actgcatcaa cactttctgt ggaatagctt
     1441 ctacatcaga agcatccggt tcttcatatt cttcaggcaa ctcttctaat ggtgccgact
     1501 gattgattac atcatttttc cggagatatt gcaaagctgt gttgaccatc accctttcca
     1561 tccaagcccg cagggagcct tcacccctcc aggtgaactt gtcgaaggaa tcgaatatct
     1621 ttaaaaaacc gtcgtgaagc agatcctggg ctgtatcacg gtcgccggta tagcgaagac
     1681 agatgccaag catacgtccc gcatactgct catacagttc tttgcgagct tggttattgc
     1741 ctagcctgca ttgttccgac aactctaatt cttccattct cttatacacg tgtttaactt
     1801 ataaatgcag caaagataga aatactgcat agagagaaca actcttttat cacttttgtt
     1861 tctttaacag attcaaatgc aatattttct atcccattgc attttcacaa tacaaaggaa
     1921 ccattttata taatctaaaa cttaaataag tatatgaaga aatttaaatt cattgccttt
     1981 atctttgcta ttatgactac aatgccgatt ctccagtcat gtttggacga cgatgacaac
     2041 ccgtccgatc ttctggttgt cagtaccatc aatatgatta gccaggatag caaggaattt
     2101 tatttcactt tggatgacgg gaaaaagatg tatcccagca atgcgcaagg atggagtaat
     2161 aaagattggg tggaaggaca acgagctttt gtgatcttca acgagctgga agaacctgtg
     2221 aatggatacg accttaatat tcaggtgaga ggtatcaatc caatcttaac taaagacatc
     2281 atcacgatgg gtgaagatga caacgacgaa gaaaaagtcg gagatgacaa gatcaacaca
     2341 acttatatgt ggatcaacaa ggataataaa tatctgacga ttgaattcca atattatgga
     2401 acgcatagtg aagataaaaa acatttcctg aatctcgtaa tcaacgacaa agaagagtct
     2461 gctcccactg ctgacgaaga cagtgcggag gacgaatata tcaatctgga attccgtcat
     2521 aacagtgaag gtgattatcc tcaaagcctg ggcgaaggat atgtatcttt caaactggat
     2581 aagattaaag accggatgga agggaaaaaa ggattaagga tccgtgtcaa cactttatat
     2641 ggcggaccga aaacttacga agtaaagttt ccctaagatt ataaatctaa tgtaaacgtg
     2701 caaaacacac tcttttttaa tataatatat taattacgca aaagagggcg gtagttgtga
     2761 aactgccgcc cttttacttt cttctttata ttctttcttc taaaagagtt atttcttatc
     2821 tcccagataa ttccaaacta ccgcactcaa cgcagctcct acaaatggag caatgatgaa
     2881 cagccacaac tgcgacaatg cttctcctcc ctggaataat gccggagcaa tactacgtgc
     2941 cgggtttaca gaagtccctg tgataggaat acatacaata tgtaccaata caagagtcaa
     3001 accgatggca agtcctgcca gattgcctgc tcccttcttc gagtcggtag agccgagcac
     3061 cactaataca aaaatgaaag taaatactgc ttccgcaatg aatgcctgca acatttctcc
     3121 atcgccaaaa ccattggaac ctgtagccgt aggtccgtca tgagcaccgg tggaaactaa
     3181 agcaaaaaga atagccgagc cgataatagc tccgattacc tggaaaatca tatacatacc
     3241 tgcatctttt ccgttcatac gcccagttaa gaacactcct aatgtaatag caggattaat
     3301 gtgacatcct gaaatacctc cgatagcata cgccatcgct actactgaaa gaccaaatgc
     3361 taaagctacg ccgactgttc ccacgccagc acctaccgta ccagttacac taccggcaaa
     3421 aacggcactt ccgcatccca taagaacgag caccatcgtt ccaatcattt ctgcaatgta
     3481 ctttttcata actataaata atggttaatg catcaaatat agagaattaa cccaagaaaa
     3541 caaagcctac gtgcctaaat tattattgct ttcgcaacat ttttgaataa aaggcaagca
     3601 aataaaatga aaaaaggact tttgcacgcc atattagcct ctaccttatg ggccatcgta
     3661 aactctctta tcaagcaagg attgagcaat gacgtcactc cgatgaattt ctccgaaacc
     3721 cgctttgcca ctgttggagt tattcttttc gcttataccc ggtacaaggg tatatgacag
     3781 gaatcatctc aacctctatt attatagcaa acactgtatg gactgcaaag taagcatttc
     3841 tttggggact gcagctttta tttcctcttt cagaacacat agcaggctgt gacgaataaa
     3901 atctctattt gtcgccaaca ccacttgccg cgtcggtcgg gggatagcaa acggacgtac
     3961 taattgtcgc tgttcttccg tcaattgagc cactgccagt tcgggaataa aagtgattcc
     4021 ttttccgctt tctaccattc tcataaaggt ttccatgctt cccaggcgat aagccatctg
     4081 actaaccttc accgcttcca tctgacagaa acggacaagt tggtcacgaa aacaatgtcc
     4141 ttcgtccaaa agccaaagat gttcgccggt tatatcggaa gtgcggataa cgtcatgttt
     4201 gaacgagggt tctttccgtg atacataagc ataaaattgc tcatagaaga gagtttctcc
     4261 cgtcaagaat gtgtcttcta atttactggc aataatccct gcatccaaat cgccggcatg
     4321 cagagcctgc tgaatatcct gggttttcat ttccgtgaca cgaatatcca gttcgggata
     4381 tttctccatc agttgaggga aaaagcgggg tagcaaataa ggagcgatag tgggtaatac
     4441 tcccaaacgg aatacacctg ataatgattg cttatcttca ctgatgattt cttttacttg
     4501 agctgcctgc gccagaatca cacgagcctg gtctatcact ttctgcccga tgggtgtcgg
     4561 gcagacgggt tgcactgtcc tatcgaataa ctttactccc aattcatctt ccagcttctg
     4621 aatcatggca ctcaaagtag gttgcgtcac acggcaatat tcggctgccc gtgcgaaatg
     4681 cctgaactgg tctacggcta gtatatattc taattgttgt atcgtcatct atcaaatcat
     4741 attaagttat agatttcatc tatgcaaaga tagaaatttt cagtttgaca acaagcattt
     4801 tccgccttat ctttgcagta cagaaaaaaa agaaaacaag tataaatcat taaaaataaa
     4861 aagaatatga aaactttaga atttatcaaa ctgaatgaat cgggagcaaa caacgtagta
     4921 gcatctttgc aacaactatt agcagacttc caagtgtatt acaccaatct ccgcggtttc
     4981 cactggaata tcaaaggaca tgatttcttt gttctccaca gccaattcga aaagatgtat
     5041 gatgacacag ccgaaaaggt agacgaaatt gcagaacgta tcttgatgtt gggcggtact
     5101 cctgccaata aattcagcga ttatttgaaa gtagcaaata tcagtgaagt agataaggtg
     5161 agcaacggcg aacaggcact gaacaatatc cttcagagta tcagttatct gattggtgaa
     5221 gaacgtaaaa tcttgtctat cgcttctcaa gccggagatg aagtaaccgt ttcgatgatg
     5281 agcgattatc tgaaagaaca ggaaaaacta gtttggatgt tgacggctta taatagcaaa
     5341 taattaagat aaaaggttta ggtttttaag tgagaaagag aggatatttc cgtaaaagga
     5401 atattctctc tttattattt ccagtgtact agtactatct aaatacgttc attcgctgat
     5461 attattaaaa aaattagttt tgttctttat ttatcaagat ttataaaagt aagcaacaac
     5521 tttcaaaaga tgaaacttat tctactgaaa taaaatgtct taccctgaat tttgttgact
     5581 ctaataagtc tcaactaaaa ctagggtaag acaattagag gcccctgaaa cgttgatgaa
     5641 taaaggattt caatcaaggt gtgagagtgt gagtgtaaaa cgtcgtcaac atttgtttgg
     5701 ctaaaatacg acacttcgca cgattaacct tgccgttttc tgtttgcgga atacaatctg
     5761 tcgtccatat gtacttggga cgataataag gttccaatat ttcctgtagt ttgtttccga
     5821 tttctttagt gtccggctga ccttccaata attctggctg accttccaat agtaaggtta
     5881 cagcctgccc taaacgctgg tccggaactg aagtaataac aaatggcaca ggaataaaag
     5941 aacgaagcaa tttctccatt tcctccgcct gaatcttaat tcctccacta tttatcacat
     6001 tgtctttccg acccaaaatc ataaaacttc catcgggata gatgcgtgca atgtcattgg
     6061 tttgcaatat ttcatcacat accaaagggg catcaataat taacgtattc tctacagata
     6121 aagacagttt tactgaagaa aacggataat aatgttccga agccaatgtt ccgttcagcc
     6181 gacgaagagc aatatgagat aaagtttcag tcatgccata ggtagaatag acggcagtcg
     6241 gaagatgttt gatctccgcc tctaaagcct catcaatagc tccaccacct ataatcaaaa
     6301 tatccgtctg tttcaatcgt tctttctctt cgggaacttg caacgtatta taaacttgca
     6361 ggggaaccat tgccacaaat ctcaaaggct cttttatatc cgctaaagga tgaccggaag
     6421 caggacgtac aatcaaattc aagcctgcaa ccaacgaacg cacgaccacc atcattgcac
     6481 caatataacg aagattcata caaagtaatg ccgtctctcc tttcttcaaa tccagaaact
     6541 cacaagtcag acgcgcactt tgcatcatct ggtctttacg tacaatcaac tctttaggtg
     6601 tacccgtaga gcctgatgta tgaacaatga tgacaggaga atcgttaaac cattcgttca
     6661 ggaaaagata taaatcccaa ctagcaggag aatgagcctc cgctcctcct gctattaatc
     6721 ggcttatatc ctcaaaagta tattcttttc cttccagtaa caagcgttgt tgttttcgat
     6781 cgaatatcat cggaatatcc tttaaatact atcatttaca aaaccataaa caatcttttc
     6841 ttatttcaag aggcacttcc acgttgtctg taaagagcgc ccctgttccc agtccctgtg
     6901 gcaacggatt gctgaatgtt gcacaccact gggcaatggc gtttagccca atgtttgatt
     6961 ccagagcgga agttatccac cagccgatct gttgtttttc agcttcggta atccattcgt
     7021 ctcctccgca tattcctcca tgaagagaag gtttaataac gatatattgc ggacgaattg
     7081 ttgaaagcag ctcctgtttc ctttccagcg tattgcatcc tatcagttct tcatccaaag
     7141 caatcgctaa tggagattcg gcagcaagcc gagccatttc ctcccattgt ccggcacaga
     7201 ttggctgttc gatagaatgt aaatcaaact cggacagacg tttcagtttt tccattgcgt
     7261 ccacgggtga gaaagcacca tttgcatcta cacgcaactc tatttcttta gaagagaaat
     7321 gcgtacgaat atggcgcaac aatgtcagtt cttcttcgaa attgatggca cctatcttta
     7381 acttgataca acgaaatccg gcttccatct ttttctcaat ctgggataac atgttctgaa
     7441 aatctcccat ccaaataagg ccgttaatcg gaataccaac ttctccacgt gagaaagccg
     7501 tatcacataa agcccagttt cctgcaaaga aatgccggat ggccgtttcc agaccaaata
     7561 aaattgaagg atagtcacac aagccatcca tatccaatct gccttgttcc ctctctactt
     7621 tccggcagac tttcactaat atatcttcgt aatcaggaag atcgtcacaa cttaaagcgg
     7681 gcaaaggtgc acactcccct attcccactc tgccagggaa gtcaggagag gtaaaatgaa
     7741 gataccaaac tttacgcgta gtatatgttc ctctggaagt cccggcaggt tgcttgaaat
     7801 ggagcaatcg gggaataatt tctattttac aattcatcgt gaataatttt tcaattcacc
     7861 acagaataac acagagcctc acgaagtttt aataagttat atctcttgca gttctcctac
     7921 cattctctcc tccacagtct tgctttgcag aaaatcgggc ttaaacgcag gaaaagcaaa
     7981 ctctgtggta ctctgtggca aagccgattt taagggaatt tcggatattg tttgaagttc
     8041 ggtttacgtt tctccagaaa cgcattcttt ccttcctgtg cttcatcagt caggtaatag
     8101 agcaacgttg cgtcacctgc caattcctga atacctgctt gaccatccag ttcggcattc
     8161 aatcctgctt taatcatgcg caaagccaac ggactaagca gcatcatttc ttctgcccac
     8221 tgcacatatt catcttccaa ctgctccaag ggaactactt tattcactaa tcccatatcc
     8281 aatgcttctt gtgcattata cttccggcag aggaaccaga tttcgcgtgc tttcttctga
     8341 ccgaccacac gtgccagata agacgcaccg aatccagcat caaagctacc tacacgagga
     8401 cccgtctgac cgaaaatagc attttccgac gcaatggaca aatcacatac cacatgaagc
     8461 acatgtccgc caccaatagc aaaaccgttc acggcagcaa tcaccggttt cgggatgctg
     8521 cgaatctgct tttgcacatc caatacgcta agacgaggca caccgtcttt tccgatatat
     8581 ccgccacgtc ctttcacatt ctggtcgccg cccgaacaaa atgccttatc accggctccg
     8641 gtaatcacaa tcacatcaat atccgcttct tcacggcaga tgcgcaatgc gtcactcatt
     8701 tcagcagtag ttgtcggagt aaacgcattc cgatagcgtt cacggttgat cgtgatacgg
     8761 gcaattccat tataataatc aaaaagaata tcgtcgtatt ctctaatggt tgtccactct
     8821 ctttgtgttg acataatcta tttttgtttt aattgatgat aataattctt caacatgcgc
     8881 gcgtccttgt ttttgttggt aaacacctcc aagagcacag gctgttccat agcttccggt
     8941 tgagtgaaag ttttcatcgc ttcagccagt tcttcgtcat tttgtgcttg cagatagagg
     9001 aatccacgtt cctccgccca acctttggcc gacgttttat ggactgccgc aataaattta
     9061 tgtgaggtac ccgacatatc caatcccggc aaggtatgga aaatctctcc tcctccatta
     9121 tttaacagaa gaacacgcag attggagcga acattgacat tccacaatgc attcatatca
     9181 tagaaaaagc tcaaatctcc gatagctata aagttcagtt tgtcggaagc tgccgcataa
     9241 ccgacagccg tagacagtga gccttcaatg ccgtttgtcc cccggttgca acaaacttca
     9301 atcgtagaag gaatggagta taattgcgca taacgcacca ccgaactgtt tgccagatgc
     9361 aacgcacatg actccggcaa ggctttcaat aacgtaccga cggcagacat ttccgaataa
     9421 gcaaactccg gttcgggaat gatcttgcaa tagttttccc acacacgggg atattcagga
     9481 gtccgattgt ccagcaaact ggctatcttc tccagaaact cgaacgggtc catttcgatc
     9541 accgtagtta atgagccgta caaatcgacc acctcaccat ccggcgatac gtgccaatgt
     9601 tctttaggcg gatgctgacg gagaaacttc ttcagccgtt tggaaacgac atgtcctcca
     9661 taagtaatca acaactccgg aaccatctgg ccgaccttct cttcgggcat ggcataaagc
     9721 gccgcatcaa agttctttac cggaataccg ggaactgtct ggttgccgat atgttcagtc
     9781 aaccaggcaa aatgtttata taataacttg atatatcttt tttcaaacag gtagataaga
     9841 ttcatctgac cgatgataat cattcgcttc tggtatttat tcatccgatc gaccaaatca
     9901 ttataatcac gatcgtagac gttcaacccc tgataacggg taatgacacg cacttcagga
     9961 agcgaatcaa ccgtaaactg gaacaacggt tcagaaatag ggacattaat atgtaccggt
    10021 ccttttccat gatggttcgt ttccagcaaa gcttcattca ccagacgatt gcaataccat
    10081 tcatcttctt ccgtatgaat ctccggaagg tttactgact tcttaaccaa tgtctgaaat
    10141 acgcctggtt gtggtactgt ctgtccatcc atctgcccga tccaggcagc gggacgatcc
    10201 gcagaaataa tgaccagagg aacattttga taaaatgctt ctgccacagc cggatgaagg
    10261 tttaataatg cagtaccgga agtgcaacag acagctgcgg gcttaccacc attcaacgca
    10321 agaccgatgg caaaatagcc ggcactccgt tcatccgtca ccggatagca ggtaaaattc
    10381 ggatggttag acaaagtatg tactatgggc gtattacgac tacccggaca caatacaacc
    10441 ttagtaatcc catgcgcctc gagcaacgca accaactgga gtatgttctt cttgtctgta
    10501 tacatgatga taattattag tagtttatga ttttaaagga ggcactgcaa tcagccgttt
    10561 gatggtttgc aacttcttct ccgtttccag ccattcgtca ttcaattccg aagaggccaa
    10621 taatccaccg ccggcataaa gagtaagttg tttatcttcg atatgcatac agcgtaagtt
    10681 tacatagatg tctgttcgtc cttccggatc gagccatccg ataaagccgg agtaatagcg
    10741 gcggtcgtaa ccttcattct gcaaaataaa ctgataggct tcttccttcg gcaagccgca
    10801 tacggcaggt gtcggatgca aaactttcag aaggtctccc aaacctttat tatctttcaa
    10861 agaaaaacgg aaatcagttt ttaaatgtga caaagcaccg gcataagcag gatatggccc
    10921 gttttccgta gaatgaatat ccagtgaaag aagctgccga cggatataag aagcaacata
    10981 atcttgttct ttccggttct tttcatccca tacttgcggc aatctgccat cttgcaaagg
    11041 ctgtgttccg gctagtgcaa ccgtatgcca ttcgtctttc tcacctgata aaatgatttc
    11101 gggagtactt cccagccaga tgcccgtctg cggagtataa cataagtaaa tatacgaatg
    11161 aatataacgt ttacaagccg cccgaaagat ggacaaagga gaaaaatccg caactttatc
    11221 aactgtaaga tgacgggaaa gcactagttt atcaaacgtc ctgtcacgta acgcatttat
    11281 aaaggtatga aagcatgccg catattcttc cgtagaagaa gtcagaaatg attcttgtcc
    11341 ttgcaggcgc aaggctatct cccgatcttc ttccgtatca tcatccacgg gtaaaggctg
    11401 cccccactga tcgggttgaa tcaacacaac cggacatgac tcactcacct gaaacggagc
    11461 aattacaaat cctctctgtc cattcagttc tttcaaatcg tatatcaaac ggaccgctcc
    11521 ttccgcctgc gtcaacagac ggggaacttt ctctccggga atacggtaaa cagcaaacgg
    11581 ctgcttccgc tgaataaatg catcaatagt tgtcaagtta cttatttctt cgtcggtcat
    11641 ctctttttca tcacactgtt gactacccgt atggaagaca ccagtttgtt tgttgaagta
    11701 aacacgtcta cattccatac gtgggaggaa cgtcctttat gtacaactgt tcctactgca
    11761 cgcacggtat ctccttcatg tgcagaagat atatggtttc cgctgacctg cattcctact
    11821 acaatctcgt ccggctggca aagaatcatc gaaccgagtc cggcaactgt ttccgccaac
    11881 gcaagagtag ctccaccatg caaaatgcca aaaggctgac gggtacgatg gtctaccggc
    11941 atcgttgctt ccacacgatc ttcgtcggcg tatgtatatt gaattcccaa gtttcccatt
    12001 aatgcgtggc gtgcctgcgc attcagttgg tcaaggggaa tttcggctgc acgcacttcg
    12061 gctatgatag ctttctccac tgcaacggcc actccgtctt cctcattcga agcagtcaca
    12121 tagtcggcac aggctttgac cgagtcttgt gaatgtccca tagctacacc cagcccggcc
    12181 aactgaatca ttgttacatc acacacaccg tcgcccacag caatcacttc ctcacgcttc
    12241 acatccagca cctccagcaa agcacccaaa gaattggctt tgtcgatggc gcagggaact
    12301 acttccagaa aatatggctc cgaacggaat acgtccaacg ctccgttcaa tcgtctcttc
    12361 cagtgatctt ccagaccaac cagtgcttct tcgtcatcgc tcaccagcat acacttacaa
    12421 ggagcaaaat caacggcagc agaaaattct tcttctttaa ttatttgcag gttattcaac
    12481 cgggcttcat tttggatatg ttcattttca ggagaatccg ttatgatcgt atcatcatga
    12541 taagtgaata aggcaaaacc gtttttacgg gctttctttt ccagatacgg caacatttcg
    12601 ggattaatcc gacgttcaaa cagaatttcc ccgttttgtg cattgataat ctgacagcca
    12661 ttataggaaa ggataaaacc tccatagttt ccaagttcaa gcatcttggc cagcggcatc
    12721 aggccataag taggtctgcc ggatgccagc acaatacgta ctcccatttg ctgaaccttc
    12781 aacagggcag ccaatgtacg cttactaatt tctttcgcat cattgaggag tgttccgtct
    12841 acatcaagaa ccaataattt atacttcatg attacacgat tttgatttag attacaaagg
    12901 taggaaattg agtgaacgac agaaagcgta aacagataaa a
//
