LOCUS       gnlProkkaNEJPABOP_22   16670 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NEJPABOP_22.
ACCESSION   gnlProkkaNEJPABOP_22
VERSION     gnlProkkaNEJPABOP_22
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:10:49
            Original ID  :: gnl|Prokka|NEJPABOP_22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 8362
            Orig. end    :: 25032
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16670
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10841]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10841
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16670
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16670
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             955..1056
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MKCLSRMTGNCHVRFLGGKAVVTPLTQPITLRW"
     CDS             1053..1964
                     /locus_tag="ctg22_14"
                     /transl_table=11
                     /translation="MNRLKGQVIKISPNSTQFINPMDINANYSEEDNPLSLKADFILSL
                     CELVVGGKEGLLPVEKTVIDRCVHLIYRKYFADPCPENMPILEDLYNALLQQDEKEAHH
                     VATALEIYVKGSLNLFNHRTNVNVNNRIVCYDIKELGKQMKKLGMLIVQDQVWGRVTAN
                     RSSGKSTRYYMDEMHLLLKEEQTAAYSVEIWKRFRKWGGIPTGLTQNVKDLLSSREVEN
                     IFENSDMIIMLNQAAGDRQILAKQLNISPHQLSYVTHSGEGEGLLFFGNVILPFVDRFP
                     TDLELYRIMTTKLGEVSEGAQK"
     CDS             1961..3694
                     /locus_tag="ctg22_15"
                     /transl_table=11
                     /translation="MSEPKLNIKEETSAKKTRSPPKKAKAEQTVPKKKKLKTDADKAAE
                     KAQHLRFGKAELTPDELSRLSKAQKREMYAAHAARSAVHHEVDQYEDENVGVQALSESE
                     KAAGNVRDISKSRYARKLKKKAKMQGKKGARTAKSSVQKPTAAQDAGASGTSEGGSNWL
                     SRWKQRQEIHKSYYTAARSGTAAQTAGGKAASNGASAARSGVEQAVEKGKTAVSTAVKG
                     LANAAKGNAHVLVIVGVFLLLILMVMSGFSSCGILFSGGTQVSGQTMYSAEDRDIRGAE
                     QDYKKLEKELDKKIKRTPTDHPGYNEYQYHLDPIEHDPWQLTSFLTTLYNDYTRSEVQG
                     KLKETFKKQYKLTTWVEVQTRYMTVWVMTPAGIPVPTQVPYEYRIFHTKLVNRGLEVVI
                     REELDNDQWKRYEIFQDTLGGRPYLFYGGLPPGGSDGSGTPGIDYQVPAEALTDSEFAA
                     IYKEAQKYVGTPYVWGGSTPETGFDCSGYVCWVYNQNGYDVGRTTANGLWQKSQHISEA
                     EAKPGDLVFFKGTYDTPGMSHTGIYLGNGMMVSAGDPIKYANIHSSYWEKHLAGFGRLS
                     K"
     CDS             3691..3972
                     /locus_tag="ctg22_16"
                     /transl_table=11
                     /translation="MIGGITMSEKSDKLRAMLAKEKERRIKLNNRIEILERRIQEEDSA
                     EVNEMVRTAKVTPEQLAALLRQSATTTPNPAALSAVGATFEKEDADED"
     CDS             3962..4699
                     /locus_tag="ctg22_17"
                     /transl_table=11
                     /translation="MKIKKLGALLVSVALCAGMAAPAFAYGGEPVEEVEQPVLTSTTDE
                     EDVVTVTDEETGALTPEGNLTLVDDYHTDYSDGSGQQFITLVSKSGATFYLVIDRNAKG
                     QQTVHFMNLVDEADLLSLMEEEEANAYTAEKEAAAQAEQDKLKAEEEAKKVAEEAAASG
                     TEQPKENKVTKIASGFLGVVVLIALAAGGGFYFYHQQMQKKKAEKEALDPDANYTEDKG
                     DFEIPTDVPDEDETPDEQDTEPI"
     CDS             4647..5081
                     /locus_tag="ctg22_18"
                     /transl_table=11
                     /translation="MCRTRTKPRTSRTLNPSDFKAAFCRRTYPNENRLEGTLISILVVA
                     EKPSVAMSYAKVLGATNRQDGYLEGNGYLVSWCVGHLVELAPPNIYDAKYVKWSIADLP
                     ILPERWQYLVSASTKKQFGILQKLMDRPDVDSIVCATDAG"
     CDS             5167..5448
                     /locus_tag="ctg22_19"
                     /transl_table=11
                     /translation="MKRNQNPDHNHSQKVLSCRYNMDTNRVEARFEDGTTLSIDCIAIE
                     DEYGNTPTQRAELDWLFYNKPLEYAKLVLRGEIEHYLSLGCDHGRLEY"
     CDS             complement(5534..7198)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 158.8; E-value:
                     3.5e-48)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_20"
                     /transl_table=11
                     /translation="MHDSNMKTIICFLQKHFLGQTPQILFVTCFSMVVALLSQSSVYIS
                     GKFVDFLTTTQNDMSAYKTLLNYSVLFVILNLTAVLINFAINRMVTILYSNTFYSITRT
                     VSQHIQSISLYKEIKFNSSKITHQLQVDAKEIVSFSLGIFQNFPLNICKLLFSIIMLYF
                     LSKSVLLIIILLVFVYVFFYASLKPKLFKSIKELKTVQSKFFSKLFEQIQFSSYVKRHG
                     LLSSFINRLNLPFKSLYEKMLENQILQFQFSGIDSIILTIGQIMLFILGGYLVLSQKLS
                     VGEFSVINLYFSSIITTIRYFYSVGTSFQNMRVSFNRIYEFLKIPCIENGNETIDSIIN
                     VSIENLKIQFDSKIVISEFHKEFIQGKMYIVAGANGSGKSTLLHTMAGLYDDLYLGSIK
                     YNNIDIRKLDMEMLRHSQIGFVEQDAPLIEGTILYNLYPSKTQEDYSANEILRAKEMVD
                     MFGLHDRILKSCDGLNMRIDEKNHLLSGGERQKIAIIRELLKQPSLLLLDEPTASMDQT
                     SAEILLNELNSIKKDVIVVITTHDERILSYGEEILYL"
     CDS             complement(7203..7727)
                     /locus_tag="ctg22_21"
                     /transl_table=11
                     /translation="MIPNNIIRMLFGLFFAIISVAFLLMHKNDIILEESDRKNNYSISI
                     ICISVILLLFIIVGYIILKELQVIVLSDSQEIFLSEILVFGFMAIFGNCSKKLPFNKYV
                     GLRLPWTLDNCLTWRYAHMLLYELTFPTILLGITFLFALPNKSKTVMIWSILLYIGTPS
                     ILSYFYCRKRH"
     CDS             complement(7814..8872)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_22"
                     /sec_met_domain="PF04055 (E-value: 6.7e-19, bitscore: 60.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.2e-12, bitscore: 36.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVSKTKDSVTGPLHLALDITNKCNYRCLHCYNASGENCVVNNEL
                     TDEEVLELINQISKIKPHTFCFCGGEPLLRKDLIVNCSEILYRNGVSAISAVSNGYYLT
                     EEIADELVQAHVSGIQISLDGFSKNSCFELRQNVDAFSRAVRAIEILSKYKDKISIGVA
                     FCPTKFNTGEFEAVYNFCKANGVRQLRVQPLMIIGRASKHVEEIKPSDEQYVQLIRKIY
                     ELNKSSIQVVSNEKKHVLYKNPICIEWGDPLDHIFRYREGNDSCYTTMSIKANGDIAPS
                     PYLPLSIGNIRCHTLQEYWDSGYSKIWKLPILKKMASTLNTVDDMQCDSMGYNTWIDRD
                     YSCDIVDEHLME"
     CDS             complement(8883..9734)
                     /locus_tag="ctg22_23"
                     /transl_table=11
                     /translation="MISINLNNKENLKLTPIFVKNRIPYIRNENNGCITIALPEKRIPQ
                     YKILNKSAVEFSNLMDGTNTVQMILDLLAKKYGENHRTAITADMGIVLSTFLSLKLIIF
                     KKGEFPTMDGITMPLNDKLVVKFAFEHDLKNIVLALDSVKTSDNFTFSSPLAYNAIPDL
                     LQLRSSVFELGKIYFLLLDDTETIRGIAEFETSAISRYITNSVAILSYVSCPSKNLDEF
                     VKGCASLINKVALCRTTKIRTYIPVDQPEAIESFSHSGFEKAAFLKEEYGKIDVCMMDY
                     FV"
     CDS             complement(9799..9981)
                     /locus_tag="ctg22_24"
                     /transl_table=11
                     /translation="MDTEYTSPIIEEFDDPTDTFKDNEFVYTYAILAVVGVVAITFGAV
                     LIEMVSLDADGKPVA"
     CDS             complement(10001..10129)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_25"
                     /sec_met_domain="TIGR04223 (E-value: 4.5e-14, bitscore:
                     43.5, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIIYWLSKLTCVVAMGMAVASVNSTCFFTAYQPDVPEDLK"
     CDS             complement(10185..10841)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_26"
                     /sec_met_domain="AgrB (E-value: 6.7e-37, bitscore: 117.8,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTSCEQTGIRQYKEDTRLFLFINENFMLERTISRKVVEWLYGHE
                     IIERSESNIYVYAYELLISSTISIFLILIASCVCGNIWYSLAFLLGFIPLRIYLGGYHA
                     SSHFNCYLAFLSVFLASVVLSYQIVATYGFRLMTTCLLFIIAFLYAPVEAKNKRLPTEK
                     KRKYRHISICLTGFDVILVTTDILPLSRFTTIYYFSKWALIIFAVIPCLTRKFQR"
     CDS             complement(10886..11065)
                     /locus_tag="ctg22_27"
                     /transl_table=11
                     /translation="MEKSTGILLLIAVAFRLLVLFFFSQSIFLTQLSISTFIVVMIIAI
                     ILLIRKWLHWRNSK"
     CDS             complement(11096..11593)
                     /locus_tag="ctg22_28"
                     /transl_table=11
                     /translation="MKKLSRRSFLALSGSAALLMAVNPLMANAAITEPELKSYYVAPIG
                     ESGTIQLDNSEHGTITIRPDTPIQGRANGDPVIHGTYTVEYNSIGSHFEYKVDTNSSYK
                     ITAAYDLDYTTVHEILSHSLTHTSTMASLKIEFKYFSVAGTANAYLNFVIRNGKIYVET
                     NM"
     CDS             11814..12512
                     /locus_tag="ctg22_29"
                     /transl_table=11
                     /translation="MAKYTVAVCDDEKEDLSFIVRKITEYDTHQLFEIKTYTDGELLFD
                     ELKSQKTSIDLLLLDIEMPSNGFQLARTLQALPKHPMVIFVTRQHEYAVQGYGIAFRYL
                     TKPLNDLLFKSAMDAATQELASRRFLVECDGGTLSLETANIYYIESYGHTILVHSKGKD
                     FQLRMNIQDAAKQLPKRCFTAPHRCYLVNMEHILYTSLDEIMLSNGAKLPISRRKRQEF
                     NQAFNTYLGR"
     CDS             12514..13776
                     /locus_tag="ctg22_30"
                     /transl_table=11
                     /translation="MYYFIELAGSVTNIALLSLFMSRLFVRNKIQSKWHSAFLTLLCTG
                     QCVLSLFPNWVIPRTLYLLLGGFLLARLFYEVQTWPAAFASGSFFVLGSVVEILAMLLI
                     GVRLPDTDLLMQAGAVRVIYVVFSNLLQIPLLILVSHFFNREESDLRIVWLFPLISIQL
                     ASISVCYVVQCHAADKDFPDYMVFFIAVLLFVNIMIVFYVEALRKNEKEKYLAELTEQH
                     YHLQIEYYQQLLEKQQETKALWHDIKKYTAAMQAVAAQNDSEQLRQIAQAAEDAYERVK
                     DISAVGNPVVDALLNQYLRSAKENQIQVLLDITIPEVLAISTLLLSVVIGNTFDNAIEA
                     CRLINPEKREIHLQLRKQNRILFYSIENPYIDAVTQLRVGKHHGYGLKNVERAVNQNNG
                     NFQLEKVDGNFIVQIRLNCEN"
     CDS             complement(13759..14157)
                     /locus_tag="ctg22_31"
                     /transl_table=11
                     /translation="MDVAAFVNVMHHLCKRQHDFRLTERDFQKLHHLIVGQFSRTDQKA
                     FQHSGTSAKTMYTLSPVQLRHPALKDFLSMLTRAQLLLCFGFFAAEVRKVGFRLGHGIT
                     LLFQKIKSQTISMEADHLAVETYLILTV"
     CDS             complement(14182..14394)
                     /locus_tag="ctg22_32"
                     /transl_table=11
                     /translation="MNGLESYSVLLAALDGVLCASVLGGSRKRIAAKQRKENAVFLGME
                     SGWRTNASFDFIEPSARPQFHRNGV"
     CDS             14426..16018
                     /locus_tag="ctg22_33"
                     /transl_table=11
                     /translation="MGVMPIPCPHFKITIVKRSQGQSAVAGAAYQSGERLFSEYDQKTK
                     FYNKKKELVHAEIMLPSHAPPGFADRQILWNAVEAVENQWNSQLARRIVLAFPVEVPKE
                     QYLSMIKEFCQEQFVSKGMIADFAIHDKGDGNPHAHILLTLRAIDEHGKWLPKARKVYD
                     LDENGERILLPSGNWKCHKENTVDWNDQKYAEVWRHSWETITNRHLEAAGRPERVDLRS
                     FERQGIQQIPTVHLGPAAHQMEKRGIETFLGNLNRDIRAANSLMQSIRSAIRGLQRWIA
                     DLNEKKQLLLDALEKAKEPTLSDLLVDYFNLRNEQRSNWSSRAQIKCTARDLAEIMQAV
                     DYLKAHSLNTIEDLDTAISNLNQTAAPLRRQLKQNENRMRAIAQIKDAAAVHAKLKPIH
                     DAFIKKNFKLTKDAYAAQHKEELDTFNKAVRTLMKLNGSTAVDFSALDAEFSALQSSSA
                     ELHTQLETLQPDVSALKNIRKYIDMVLNKQQLSAPGGKMPEKESVLKQLEQFQQKKSHH
                     KTTSTTPNREESL"
     CDS             complement(16072..16215)
                     /locus_tag="ctg22_34"
                     /transl_table=11
                     /translation="MTGFQRGASTINRKSGLKWGVLEKISALKVRLYSLASENSQKPAK
                     NK"
     CDS             16249..16545
                     /locus_tag="ctg22_35"
                     /transl_table=11
                     /translation="MSRGCFRCLPIERIFSKAEIWSQELQFNYKFLTNATKQAFSMPTK
                     CRASFSRPFSDYYDVLFTKLLAMLRNSLFHRLPSRRMFFVRQSPEIFHMFLDK"
     CDS             16542..16670
                     /locus_tag="ctg22_36"
                     /transl_table=11
                     /translation="MNSSIVRYFTKGTSVTRSPVITKTGWLKCQWCGASPPPDDSPL"
ORIGIN
        1 gcaaggtggt attatctccc ccattctggc gaacatgacg ctggatggta tcgagaagaa
       61 gctggtcgaa cgctttcaca caaacgcgct cggtaaggtc gattcaagat ttaagaatgc
      121 ccacaaagta aacttcgtcc gctacgcaga cgactttgtg gtcacagcgg caacacctga
      181 actggctctt gaagcaaagg agctgattcg agagtttctc gctgaacgcg gattggaact
      241 ttctgatgaa aagaccgttg tcaccaacat tgacgatggt ttcgacttcc tcggctggaa
      301 cttcagaaag tataacgaaa agctgattat caagccttcc caaaaggcgg tcaaggctat
      361 cgtttccaat atctctgaca cgattctccg cagaggaaaa gcgtggcagc aagatgttct
      421 gattatgaag ttgaatgaac aaattcgagg ttggactaat taccaccagt ccgtatgcgc
      481 aagtgatgcg ttcgcgcatc tggactacgt cctgtacgaa ctgctgtggc gatgggctaa
      541 aagacggcac ccaaagaaga acaagtggtg gatttccacg agatactggc atcgtgtcgg
      601 taatcggaac tgggtgttct ctacggaaaa caaggagctg atacgggtgg acagcacagc
      661 cattgtgcga cataccaaga taaaagctac tgcaaatccg ttcctcgatg aggcgtattt
      721 ccaaaaaagg aaattcgata aaggaatgca ccggctgact ggaaaattca agatgatttg
      781 gaaaaaccag aacgggctgt gctaccactg cggaatgccg atggatgtaa cggaagaaag
      841 agagatcttc taccttgcac caaaagcaaa gactggcgtg aaagatgttc gtaatatgcg
      901 ctacgttcat tgcgcctgtc agcgaattta tgctgagaac cgcttgaaaa agtgatgaaa
      961 tgcttgagcc gtatgacggg aaactgtcac gtacggttct taggcgggaa ggcggtggta
     1021 acaccgctga cccagccgat tactctccgc tggtgaaccg gctgaaaggt caggtcatta
     1081 aaatctcgcc aaacagcacc cagttcatta accccatgga tatcaacgcc aactactccg
     1141 aggaggacaa cccgctttcc ctgaaagctg actttattct ttctctgtgc gaactggtgg
     1201 ttggcggcaa ggaaggtctg ctgccggtgg agaaaacggt cattgaccgc tgtgtgcatc
     1261 tgatttaccg caaatatttt gcagacccct gcccggagaa tatgcctatc cttgaggact
     1321 tgtacaacgc cctgctccaa caggacgaga aagaagccca ccatgttgct acggctctgg
     1381 aaatctacgt caagggcagt ctgaacctgt tcaaccatcg cactaacgtg aacgtcaata
     1441 accgcatcgt ctgctacgac atcaaggaac tgggcaaaca gatgaagaaa ctcggtatgc
     1501 tcatcgtgca ggatcaggtg tgggggcgtg tcaccgcaaa ccgcagcagc ggcaagtcca
     1561 cccggtatta tatggatgag atgcacctcc tcttaaaaga ggagcagacc gccgcttatt
     1621 ccgtggagat ctggaagcgt ttccgcaagt ggggcggtat tcccacaggg ctgacccaga
     1681 acgtgaaaga ccttctttct tctcgtgagg tcgagaatat tttcgagaac agcgacatga
     1741 tcatcatgtt gaatcaggct gcgggagacc gccagattct cgcaaagcag ctcaacatca
     1801 gccctcatca gctttcctat gtgacccact ccggcgaggg cgaagggctg ctgtttttcg
     1861 gtaatgtcat tctgccgttt gtggaccgtt tccccaccga tctggaactc taccgcatta
     1921 tgaccaccaa gttgggtgaa gtctcggagg gcgcgcagaa atgagtgaac cgaagctgaa
     1981 catcaaagag gaaacgtccg caaaaaagac ccgttctccc ccgaaaaaag ccaaggcaga
     2041 gcagacggtg cccaaaaaga aaaagttgaa aaccgatgca gataaagctg cggaaaaggc
     2101 acagcatctg cggtttggca aggcggaact gaccccggac gaactgagcc ggttgagtaa
     2161 ggcgcagaaa cgggagatgt acgccgccca tgccgcccgg tctgcggtgc atcacgaagt
     2221 tgaccagtac gaggatgaaa acgtcggtgt gcaggcgttg agcgagagcg aaaaggcggc
     2281 aggaaatgtc cgggatattt ccaaaagtcg ctatgcccgg aagctgaaaa agaaagccaa
     2341 gatgcagggc aagaaaggtg cccgaaccgc aaaatcttcc gtacagaagc cgactgcggc
     2401 acaagatgca ggcgcatccg gcaccagcga gggcggttcc aactggcttt cacgctggaa
     2461 acagcggcaa gaaattcaca aaagctatta taccgccgcc cggtcgggca cggcggcgca
     2521 gaccgcaggt ggcaaagcgg catccaacgg tgcatctgcc gcccggtccg gcgtggaaca
     2581 ggcggtagaa aagggcaaaa ctgccgtcag tactgccgta aaggggctgg cgaatgccgc
     2641 caagggtaac gcacacgttc tggtgatcgt gggcgttttt cttttgctca ttctcatggt
     2701 gatgtcgggc ttttcctcct gcggaatcct cttttccggc ggcacacagg tgtccgggca
     2761 gaccatgtac tctgccgagg accgggatat tcgtggtgca gaacaggact acaagaagct
     2821 ggaaaaggag ctggacaaaa aaatcaagcg cactcccacc gaccaccctg gctacaacga
     2881 gtaccagtac caccttgacc ccatcgagca cgacccatgg cagctcacct cttttctcac
     2941 gactctgtat aacgattaca cccggtcgga ggtgcagggc aaattgaagg agaccttcaa
     3001 aaagcagtac aagctgacca catgggtaga ggtacagacc cggtatatga ctgtgtgggt
     3061 catgactccc gcaggaatcc cagtccccac gcaggtgccc tacgagtacc gcatcttcca
     3121 caccaagctg gtgaaccgtg gcttggaggt ggtcatccgg gaagaactag acaacgacca
     3181 gtggaaacgg tacgagatct ttcaagacac cttgggcggc agaccttacc ttttttatgg
     3241 tggcttgccg cccggtggct ccgatggctc cggcacaccg ggcatcgact atcaggttcc
     3301 ggcagaagcc ctgaccgaca gcgagtttgc tgccatctac aaggaagccc aaaagtatgt
     3361 gggtacgccc tacgtctggg gcggctctac cccggaaaca ggctttgatt gttcaggcta
     3421 cgtctgctgg gtgtacaacc agaacggcta cgatgtggga cgcactaccg ccaacggctt
     3481 gtggcagaaa agccagcaca tcagcgaggc agaagcaaaa cccggtgatc tggttttctt
     3541 caaaggcacc tacgacactc ccggcatgag ccatacggga atctatctcg gcaatggcat
     3601 gatggtcagt gccggagacc ccatcaagta cgcaaacatt cactcgtcct actgggagaa
     3661 acatctcgcc gggtttggac ggctttcaaa atgattggag gaattactat gagcgaaaaa
     3721 tcggataagc tgcgggcgat gctggcaaaa gagaaggaac gccgcatcaa gctgaacaac
     3781 cgcatcgaga ttttggagcg gcgcattcag gaggaggatt ccgccgaggt caacgagatg
     3841 gtgcggactg caaaggtcac gccggaacag cttgctgctc tgctgcggca gtctgccacc
     3901 accaccccga accctgctgc gctgtctgcc gtgggtgcaa ctttcgagaa ggaggatgca
     3961 gatgaagatt aagaaactgg gcgcactgct ggtatcggtg gcactgtgcg ctggcatggc
     4021 ggctcccgct tttgcctatg gcggtgagcc tgtggaggaa gtggaacagc ccgtcctgac
     4081 ttctaccacc gatgaagaag atgtagtcac cgtgaccgat gaggagaccg gtgccctgac
     4141 cccggagggc aacttgacgc tggtggacga ttaccacacc gactattccg atggcagcgg
     4201 tcagcagttc attacgctgg tgtcgaagtc gggtgcgact ttctatctgg tgattgaccg
     4261 caacgccaag gggcagcaga ccgttcactt tatgaacctt gtggacgaag ccgaccttct
     4321 ttccctgatg gaggaggaag aagcgaacgc ttataccgct gaaaaagaag cggcggcaca
     4381 ggcggaacag gacaagctga aagccgagga agaagccaag aaagtagcgg aagaagcggc
     4441 agcatccggc acggaacagc ccaaggaaaa caaggtcaca aagatcgcat ccggcttttt
     4501 gggtgtggtg gtgctgattg cactggcagc aggtggcggc ttctatttct atcaccagca
     4561 gatgcagaag aaaaaagccg aaaaagaagc cctcgacccc gatgcaaact acaccgagga
     4621 caagggcgat tttgagatcc ctaccgatgt gccggacgag gacgaaaccc cggacgagca
     4681 ggacactgaa cccatctgat ttcaaggcgg cattttgccg ccgtacatat ccaaatgaaa
     4741 acagattgga gggaacgctt atttcaattc tagttgtagc agaaaagccc tcggttgcca
     4801 tgtcctacgc caaagtcctc ggtgccacca accgtcagga cggctacctt gagggcaacg
     4861 gttatctggt aagctggtgc gtgggtcatc tggtggagct tgctccgccc aatatctacg
     4921 atgccaaata cgtcaagtgg agcatcgcag atctgcccat cctgccggaa aggtggcagt
     4981 atctggtgtc tgcgtccacc aaaaagcagt ttggtatcct gcaaaagctg atggaccgcc
     5041 cagatgtgga tagcattgtc tgtgcaacgg atgcaggata gtgtggttag gtgacttaag
     5101 agaaagaaaa aagagacctc atctcgttga aaatcaaatt ccaaaattat taaaggagcc
     5161 attcaaatga aacgaaatca gaatcctgac cataatcact ctcaaaaagt gctttcctgc
     5221 cgctacaaca tggacaccaa ccgggtggaa gcccgatttg aagatggaac tactctttcg
     5281 atcgactgca tcgccattga ggacgaatac ggcaacaccc ctacgcagcg agcagagctg
     5341 gattggctat tttataataa gcctttggag tatgccaagc ttgtgctgcg gggtgaaatt
     5401 gaacattatc tctcgcttgg ttgcgaccat ggtagactgg agtactaacc cttaatatcc
     5461 aaagcaaaac aatagccctc tatttgcagc cgttgcaaat agagggctat tataaagctc
     5521 agcttcttat gagttataga tataaaattt cttctccata ggatagtatt ctctcgtcat
     5581 gtgttgtaat aacgacaata acgtcctttt tgatagaatt caattcatta agtaaaattt
     5641 cagcacttgt ttgatccata gacgccgttg gttcatccaa caaaagtaac gatggctgtt
     5701 tcagtaattc gcggattatt gctatctttt gcctttctcc tcctgaaagc agatgattct
     5761 tctcgtctat tctcatgttt agtccatcac atgattttaa gatacgatcg tggagaccaa
     5821 acatgtcaac catttctttt gcacgaagaa tttcattagc cgaataatct tcttgcgttt
     5881 ttgatgggta aagattatac aaaattgtgc cttcaataag tggcgcgtcc tgttcgacaa
     5941 aaccaatttg ggagtgacgc aacatctcca tatccagttt tcttatatca atattattgt
     6001 atttgatact tcccagatat aggtcatcat atagtccagc cattgtatgt aacagggttg
     6061 attttccact accatttgct cctgcaacga tatacatttt cccttggata aattctttat
     6121 gaaattcgct tatgacaatt ttggagtcaa actggatttt caaattctca attgacacgt
     6181 taataatgct atcgatggtt tcatttccat tttcaataca tggaattttt aagaattcat
     6241 aaattcgatt aaatgaaact cgcatattct gaaaagatgt gccgaccgaa taaaaatatc
     6301 gaatagttgt aatgatagat gaaaaataaa gattaatgac tgaaaattct ccgaccgata
     6361 atttttgact gagaaccaaa tagccaccca atataaagag cattatttgt ccaatcgtta
     6421 gaataattga atcaattcct gaaaattgaa attgaagaat ttgattctct aacatttttt
     6481 catataggct cttaaacgga agattgagtc gattaataaa agaacttaaa aggccgtgtc
     6541 tttttacata agatgaaaac tgaatctgtt caaacagctt ggaaaaaaat tttgactgaa
     6601 cggtttttaa ctctttgatt gacttaaaga gttttggttt taatgatgca taaaaaaaga
     6661 catacacgaa aaccaagagg ataataatca gcaatacact tttgctcaaa aaatatagca
     6721 ttataatgga aaaaagaagt ttacatatat ttagtggaaa attctgaaaa atccccagcg
     6781 aaaaggaaac gatctctttg gcatcaacct gaagttgatg tgtgattttt gaagagttga
     6841 attttatttc tttgtacaaa gagatgcttt gtatatgctg tgaaacagtt cttgtgattg
     6901 agtaaaaagt gtttgaataa agaatagtaa ccatccggtt aatcgcaaag tttattaaca
     6961 cagctgttaa attcaaaatc acaaaaagaa cactatagtt tagaagcgtt ttatatgctg
     7021 acatgtcatt ttgagtggtt gtcaaaaaat ccacaaattt tccagaaata tacacagaac
     7081 tttgggaaag taaagcgaca accatcgaaa aacaagtcac aaaaagaatt tggggtgttt
     7141 gtcccaaaaa atgtttctgc aaaaagcata ttatggtttt catatttgaa tcgtgcatct
     7201 tattaatgcc tttttctgca gtaaaaataa gaaaggatgg acggagtgcc aatatacaat
     7261 agtattgacc aaatcatgac cgttttcgat ttattgggca gagcaaaaag aaatgtaata
     7321 cctaaaagta tagtaggaaa agttaattca tataaaagca tgtgtgcata tctccatgtt
     7381 agacaattgt ctaatgtcca tggtaaacgc aaaccaacat acttattgaa tggaagcttt
     7441 ttagagcaat ttccaaagat agccataaag ccaaacacga gaatctctga aagaaaaatt
     7501 tcctgtgaat cagatagcac aatgacttgc aactctttta atattatata accaacgata
     7561 ataaataaaa gtagaataac gctaatacat attatagaaa ttgaataatt gttttttctg
     7621 tcactttctt ccaaaattat atcattcttg tgcatcaaca aaaaagcaac acttattatt
     7681 gcaaaaaaca gaccaaataa catacgaatg atattattgg gaatcaataa ttctcctgca
     7741 attccgatca aacacaaaat tcttacaagg aacagtttgt cgtgtttcat cttttctcac
     7801 ctcaaaccta aaatcattcc ataagatgtt catcaacaat atcgcaagaa tagtccctat
     7861 cgatccaggt gttatagccc attgaatcac attgcatatc atctacggtg tttaatgtac
     7921 tggccatttt cttcaaaatg gggagcttcc aaattttgga atagccggag tcccaatatt
     7981 cttgaagtgt atgacaacga atatttccaa tcgaaagtgg caaatatggt gaaggagcaa
     8041 tatctccatt tgctttaatc gacattgtag tataacaact atcattccct tcacgatacc
     8101 tgaaaatatg atctagtgga tcaccccatt caatacaaat aggattttta tatagaacat
     8161 gtttcttttc gttggaaacg acttgaatag aacttttgtt cagttcatag attttcctta
     8221 ttaattgtac atattgttca tccgagggtt tgatttcttc cacatgcttg cttgcacgac
     8281 cgataatcat caatggttgg actcgcaatt gacgtacacc attagcttta caaaaattat
     8341 aaacggcttc aaactctcca gtattgaatt ttgtggggca aaaagccaca ccgattgaaa
     8401 tcttgtcctt atattttgat agaatttcga ttgccctaac cgctcgacta aatgcatcaa
     8461 cattttgtct taattcaaaa caactatttt ttgaaaaccc atcaaggctt atttgaattc
     8521 cagatacatg agcctgtact aactcatctg ctatttcctc ggttaaatag taaccatttg
     8581 atacagctga tattgcggaa accccatttc tgtagagaat ctcagagcaa tttacaatta
     8641 aatctttgcg caaaagcggt tctcctccac agaagcaaaa agtgtgcggc ttgatttttg
     8701 aaatttgatt aataagttct aggacttctt catccgtcaa ttcattatta acaacacaat
     8761 tttcaccgct ggcattatag caatgcagac aacgataatt gcatttgttg gttatatcca
     8821 aagccaaatg cagtggaccc gtcaccgagt cttttgtttt tgaaactccc atatacttat
     8881 cctcacacga aataatccat catacaaaca tcaatttttc catactcttc ttttaaaaat
     8941 gcagcttttt caaatccgga atgcgagaag ctttctattg cttcaggttg atctactggg
     9001 atatatgttc gaatttttgt tgtacggcaa agagctactt tgttaataag agatgcacag
     9061 ccttttacaa attcatccag atttttagat gggcagctca catatgacag aatcgcaaca
     9121 ctattagtta tatatctgga tatcgcagat gtttcaaatt ctgcaattcc acggatagtt
     9181 tccgtgtcat ccaagagtaa aaaataaatt tttccgagtt caaatacaga agatcttaat
     9241 tgtagaagat ctggaatagc attatatgca aggggactag aaaacgtgaa attatccgat
     9301 gttttaactg aatcaagagc aagcacgata ttttttaaat cgtgctcaaa tgcaaacttg
     9361 acgaccagtt tatcattgag aggcattgtt atcccatcca tagttggaaa ttctcctttt
     9421 ttaaaaataa taagtttcaa acttaaaaaa gtcgaaagca ctatgcccat atcggctgtt
     9481 atagcggtgc gatgattttc gccgtatttt tttgcgagta agtctaaaat catttgtacc
     9541 gtattggtcc catccataag attggaaaat tcaacagcac ttttatttaa gattttatat
     9601 tgtgggatac gcttttccgg aagtgctata gtaatgcaac cattattttc gtttcttata
     9661 tatggaatac gattcttcac gaatataggt gtcagtttca aattttcctt attattcaaa
     9721 ttaatcgaga tcatattttc acctaaaaac cgtcagcctt gacgagacca ctcacaacgg
     9781 ctgacggttt ctcctctatt atgctacggg cttaccatct gcatcaagcg aaaccatctc
     9841 tatcaaaact gccccaaagg ttattgcgac tactcctacg actgcgagga tagcataggt
     9901 atagacaaat tcattgtctt taaaagtatc agtgggatca tcgaattctt cgattatcgg
     9961 agaagtgtac tcagtatcca taatatttct ctccttcatt ttattttaga tcttcgggaa
    10021 cgtccggctg atatgcggtg aagaagcagg tgctatttac acttgctact gccatgccca
    10081 ttgcaacaac gcaagtgagc ttactcagcc aatatattat ttttttcatt tttttctcct
    10141 ttcttttgat ttttgaaaac ggtcacccaa aaggaaaacc gagttcatct ttgaaatttt
    10201 cgtgtcaggc aaggaatgac tgcaaatata atcaatgccc acttcgaaaa atagtaaatt
    10261 gttgtaaatc ttgagagtgg tagaatatca gttgtcacaa ggatgacatc aaaaccagtc
    10321 aaacagatgc taatatgcct atactttcgc ttcttttctg tgggaagtct cttgtttttg
    10381 gcttcaacag gggcatacaa aaatgcaatt atgaatagta aacaagtcgt catcaaccga
    10441 aatccatatg tcgccacaat ttgataactt aaaacgacac ttgcaagaaa gacagataag
    10501 aaagccaagt agcagttaaa atgtgaggat gcatgatatc ctcctaggta tattcgaagt
    10561 gggatgaagc cgaggagaaa agccaatgag taccatatat taccgcaaac acatgatgcg
    10621 ataagaatga ggaaaatact tattgttgat gaaatcaaca attcataggc atatacataa
    10681 atatttgatt cactgcgttc aataatttca tgaccatata gccattcgac gacttttcga
    10741 gagatagtac gctctaacat aaaattttca tttataaaaa gaaacagacg ggtatcctcc
    10801 ttgtattgtc ggatgcccgt ctgttcacaa gaagttaaca agaatgaaac tttttaacta
    10861 agcgagtaga tagcagtaat tgattttatt tcgagtttcg ccaatgaagc catttcctta
    10921 tcaacagtat aatggcaatg atcatcacca cgataaaagt agaaatggaa agctgggtta
    10981 aaaagatgct ttgcgaaaag aaaaaaagaa ccaacaatcg aaacgctacg gctattagta
    11041 acagaattcc agttgatttt tccattatta tatctcccgg tagcgtatgt tgaaatcaca
    11101 tgtttgtttc aacatagatt tttccgtttc ggattacaaa attaaggtat gcattagcag
    11161 ttcctgcaac gctgaaatat ttgaattcaa ttttcaggct cgccatagtc gatgtgtgtg
    11221 taagactatg agagagaatc tcatgaaccg tcgtatagtc caagtcatag gcggctgtga
    11281 ttttatagct actgttagtg tcaaccttgt actcaaaatg cgaaccgatg gagttgtatt
    11341 caaccgtata agtaccgtgg ataacgggat cgccatttgc tcgtccctga atcggagtgt
    11401 ctggacgaat cgtaatggtt ccatgttcgc tgttgtccaa ctgaatcgta ccagattcac
    11461 cgatgggtgc aacataatag gactttagtt ccggctcagt gattgcggcg tttgccatta
    11521 aaggatttac tgccatcaaa agggcagcac taccggatag tgcaaggaag ctacgccgag
    11581 aaagcttttt catggtgatc gacctcctaa aatgaaattt acaaatcata gacatatagc
    11641 taacgctata catcatgatt tttagttgat gataccataa tttcaaacaa aagtaatcta
    11701 tttgtcgtga atggttagct ttctggcacg aacggtcaat ttggagactt gctgattcct
    11761 atcctaccat ttataatggt tgtaaacacc aaatctaatt ggaggatctt cagatggcaa
    11821 aatatacagt cgcggtctgc gatgatgaaa aagaagactt aagtttcatc gtaagaaaaa
    11881 tcacagaata tgacacacac cagctctttg agatcaaaac ctatacagat ggagaactac
    11941 tttttgacga attaaaatca caaaaaacat ccattgatct cttgcttttg gacatagaga
    12001 tgccatccaa tggatttcaa cttgcacgaa ctctacaagc tttgccaaaa catccaatgg
    12061 tgatttttgt gactagacaa catgagtatg ccgtccaagg ttatggaata gcttttcgct
    12121 atttgacaaa gccattaaac gacctattgt ttaaatccgc aatggatgcg gcaactcaag
    12181 aacttgcatc acgccgattc cttgttgaat gtgatggtgg aacattatcg ctggaaactg
    12241 caaatattta ctatattgaa agttatggtc atacaatttt agttcacagc aaaggtaaag
    12301 actttcagct tcggatgaat attcaagatg cagccaagca gcttcctaaa cgctgcttta
    12361 cagcacccca taggtgctat cttgttaata tggaacacat cctttatact tcattggacg
    12421 aaattatgct ttccaacggg gcaaagctgc ctattagccg aagaaaacgt caggaattca
    12481 atcaagcgtt taacacatat ttaggacggt aaaatgtatt attttataga attggccgga
    12541 agtgttacaa acattgcact gctcagtctg tttatgagtc gattgtttgt gcgaaacaag
    12601 attcaaagca aatggcactc tgcctttctt actttactat gtacagggca gtgcgttcta
    12661 agtctttttc cgaattgggt gataccgagg acgctttact tactgcttgg aggtttttta
    12721 ctagcaaggc tgttctatga agttcagact tggccagcgg ctttcgcaag cggttcattt
    12781 tttgtcttgg gttccgtggt agagattctt gcgatgttat tgattggcgt tcgtctgcca
    12841 gatacagatc ttttaatgca ggccggagca gtgcgagtga tttatgttgt gttctctaat
    12901 ctgcttcaaa taccacttct tattttagtg tcgcattttt tcaaccgcga agaaagtgat
    12961 ttacggattg tatggctttt tcctctaatc agtattcaac ttgcaagtat ctccgtgtgc
    13021 tatgttgtac agtgccatgc agcagataaa gactttccgg actatatggt tttcttcata
    13081 gccgtcctgc tttttgtgaa tattatgatc gttttctatg tggaagccct gcggaaaaat
    13141 gaaaaagaaa agtatttggc agaactaaca gaacagcact atcatttaca aatagagtac
    13201 tatcagcaac ttctggaaaa gcagcaggaa acaaaggctc tttggcatga cattaaaaaa
    13261 tataccgccg caatgcaagc ggttgcagcg caaaatgact ctgaacaact ccgtcagatt
    13321 gctcaagcag ctgaggatgc ttatgaacgt gtgaaagaca tctctgctgt tggtaatcct
    13381 gtagtcgatg ctttactaaa tcaatatctc cgttctgcaa aagaaaacca gatccaagtt
    13441 cttttggata taacaattcc agaagttctt gctatctcaa cattgttgtt aagcgttgtt
    13501 attggtaata cattcgataa tgcaattgag gcttgccgac ttatcaatcc agagaaaaga
    13561 gagattcact tgcaactacg aaaacagaac cgaatcctgt tttacagtat cgaaaatcca
    13621 tatatagatg ctgtcaccca gttgcgcgta gggaagcacc atggttacgg gctgaaaaac
    13681 gtagaacgcg ctgtgaatca aaacaatggt aattttcagc tggagaaagt tgatggaaat
    13741 tttattgtgc aaatccgttt aaactgtgag aattaaatat gtttccacag ccaaatgatc
    13801 agcctccata ctgattgttt ggctttttat tttctgaaaa aggagtgtga tgccatgacc
    13861 caaccgaaaa ccgacctttc ttacctccgc agcgaaaaag ccaaagcaga gcagaagctg
    13921 cgctcttgtc agcatagaga gaaaatcctt gagcgcagga tgtcggagct gaaccggaga
    13981 gagcgtgtac atcgtctttg cactcgtgcc ggaatgctgg aaagctttct ggtctgtccg
    14041 ggagaactga ccgacaatca ggtgatggag cttttgaaaa tctcgttccg tcagccggaa
    14101 gtcgtgctgg cgcttgcaaa gatggtgcat gacgttcacg aacgcagcaa cgtccaaaac
    14161 cctttagaat aaagggcgca attatacacc gttccggtga aattgcggtc ttgcagacgg
    14221 ctcgatgaaa tcgaagctgg cgtttgtgcg ccagcccgat tccatcccaa ggaaaactgc
    14281 attttccttg cgctgctttg cagctatcct tttgcggctc ccgcctaaga ccgaagcgca
    14341 cagcactccg tccaaggcgg cgagcaaaac cgaatacgat tccagaccgt tcatcaagag
    14401 caatcttgct gggcggtctt tttgtttggg ggtgatgcct attccgtgtc cgcatttcaa
    14461 aatcaccatc gtcaagcgca gccaagggca gtccgctgtt gccggggccg cttatcagag
    14521 cggcgaacgg ctgttcagcg agtacgacca gaaaacgaaa ttctacaaca agaagaaaga
    14581 acttgtccat gccgagatca tgctgccgtc ccatgcgccg cccggatttg cagacaggca
    14641 gatcctctgg aacgccgtgg aagccgtgga gaaccagtgg aactcccagc ttgcccggcg
    14701 cattgtgctg gcgttcccgg tggaggtgcc gaaggaacag tatctttcta tgataaaaga
    14761 attttgtcag gagcagtttg tttccaaagg gatgattgct gattttgcca tccacgacaa
    14821 gggcgatgga aacccacacg cccacattct gctgacgctc cgggcaatag atgaacacgg
    14881 caagtggctt ccaaaagccc gaaaggtgta cgaccttgac gagaatggcg aacgtatcct
    14941 gcttccttcc gggaactgga aatgtcacaa ggaaaacacc gtggactgga atgaccagaa
    15001 gtacgccgag gtctggcggc acagctggga gaccatcacc aaccgccatc tggaagcggc
    15061 tggcagacca gaacgtgttg acctgcgctc ctttgagcgg cagggcatcc agcagatacc
    15121 aacggttcac cttggtcccg ccgcacatca gatggaaaaa cgcggcatcg aaacttttct
    15181 cggcaatctg aatcgtgata ttcgagccgc caatagcctg atgcagtcca tccgcagtgc
    15241 gattcgtggg ctgcaacgct ggatcgcaga cctgaatgaa aagaagcagc ttcttctgga
    15301 cgctctggaa aaggcgaagg aacccacgct ttctgatttg ctggtggact acttcaacct
    15361 tcgcaatgag cagcgcagca actggtcgag tagggcgcag ataaaatgta ccgcccgtga
    15421 ccttgccgaa atcatgcagg ctgttgatta tctgaaagcc cattctctga acaccatcga
    15481 ggatttggat accgcaattt ctaacctgaa ccagactgcc gcccctctcc gcagacagtt
    15541 gaagcagaac gaaaaccgta tgcgggcaat cgctcaaatc aaggatgctg ccgccgttca
    15601 tgccaagctg aagcccatcc atgatgcctt tattaagaag aacttcaagc tgaccaagga
    15661 cgcttatgcc gcccagcaca aggaggagct ggacaccttc aacaaagctg tccgcaccct
    15721 gatgaagctg aacggcagca cagcggtaga tttttcggca ttggatgccg aattttctgc
    15781 gctgcaatcc agcagcgcag agctgcacac ccaactggaa accttgcagc cggacgtctc
    15841 cgcactgaaa aatatccgca agtatatcga catggtgctg aataagcaac agctttctgc
    15901 accgggcggt aagatgccgg agaaggaatc ggtgctgaaa cagctggagc agtttcagca
    15961 gaaaaagtcc caccacaaaa cgacttccac taccccaaac cgcgaagaat cgctctaaac
    16021 gatctttctg tcaccgatat gccgttgcaa tcagtggcag aaatacataa ttcatttgtt
    16081 ttttgctggc ttttggctat tctcgctggc tagtgagtag aggcgtactt ttaaggcaga
    16141 aattttctcc aacacccccc attttaggcc actttttctg ttaatagtag aagcgcctct
    16201 ttgaaagccg gtcatttgtg acctttttgt taattctcaa aaagatggtt gtctcggggc
    16261 tgttttcgtt gcctacctat tgagaggatt ttttcaaaag cggagatttg gtctcaagaa
    16321 ttacaattca attacaagtt tctcaccaat gctacgaaac aggcgttctc gatgcctacc
    16381 aagtgtaggg catctttttc aagaccattc tcggactatt atgacgtttt gtttacaaaa
    16441 ttgcttgcaa tgctacgaaa tagccttttt catcggctac caagtagaag gatgtttttc
    16501 gtccgtcaaa gtccagaaat cttccatatg ttccttgaca agtgaatagt tcaatcgtcc
    16561 ggtacttcac aaaaggtact tctgtaactc gcagcccggt cataacgaag acggggtggc
    16621 tgaaatgcca atggtgcggt gcaagcccgc cgccggacga ttccccactc
//
