LOCUS       gnlProkkaIPLCELAE_80   13709 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IPLCELAE_80.
ACCESSION   gnlProkkaIPLCELAE_80
VERSION     gnlProkkaIPLCELAE_80
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:50:32
            Original ID  :: gnl|Prokka|IPLCELAE_80
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13709
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13709
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3334:3709]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3335..3709
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13709
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13709
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             370..1881
                     /locus_tag="ctg80_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKYFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             1954..3021
                     /locus_tag="ctg80_2"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDDK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             3058..3342
                     /locus_tag="ctg80_3"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(3335..3709)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg80_4"
                     /sec_met_domain="PqqD_RRE (E-value: 3.4e-11, bitscore:
                     34.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-17, bitscore: 55.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVVYRNLLLFI"
     CDS             complement(3807..5195)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.6; E-value: 3.5e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg80_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTIFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5444..5839)
                     /locus_tag="ctg80_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(5846..6619)
                     /locus_tag="ctg80_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6625..7152)
                     /locus_tag="ctg80_8"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7139..8380)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg80_9"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8390..9484)
                     /locus_tag="ctg80_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9489..10529)
                     /locus_tag="ctg80_11"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             complement(10548..11582)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg80_12"
                     /sec_met_domain="PF04055 (E-value: 5.3e-18, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
ORIGIN
        1 attaccttat tcatggctat tccggagtac tttaagatgc atatagtttg gataatttat
       61 ttgctatttc taatatgccg atatcccttt atccatcggc ctttcaatga gctttactag
      121 cacggaattt gattaagaac caaatctttt tcaggagaaa taaaagtaag ttcataatgg
      181 tgctgcattg aattattttt tggcggagtt attctaacac ttaatagttc aaaagcagat
      241 atttctctga cccaaagata gaactaatga tgaattaaaa gttgcaatta tggttttctt
      301 cccacaacaa acgggaaaag tcagaagaat catgtacatt tgtaatccga aaactaaaag
      361 aacatcgcaa tgaaaatatt tccaagcagc agtatcaaga aattggacgc ttataccatt
      421 gagaacgaac ctattgcatc aatcgatctg atggaacgtg cagcaaccgt attaacaaaa
      481 gccatcacag acagatggaa tacggaaacg ccggtcacta tctttgccgg accggggaat
      541 aatggcggag acgctctcgc cgtagcccgc atgatggctg aaaaaggata taaaatcgag
      601 gtatttctct tcaacacgaa aggagaactt tcacccgact gccaaaccaa taaagaactg
      661 gtagaaatga tggaagaagt aaaattccac gaaatcagta cccaattcgt acctcccgtc
      721 ctgacgcccg accatctggt aatcgacgga ttattcggtt caggcctgaa caaaccgtta
      781 agcggcggat tcgctgccgt agtgaaatac atcaattcct cccctgctat ggtagtagcc
      841 atcgacattc cttccggact gatgggagaa gaaaacacat tcaacgtaaa agctaatatt
      901 atccgtgccg acgtaacttt cagtctgcaa ctgccgaagc tcgcctttct tttcgcagag
      961 aacacggaat ttgtcggaga atgggaagtg ctggatatcc aattgagcga agacggtatt
     1021 gaagagatgg agactaacta cgaaatgttg gaaatagagc aaatccgttc actcatcaag
     1081 ccacgcaaac agtttgccca caaggggaac ttcggccatg cactattgat tgccggttca
     1141 aaaggaatgg caggagcctc tgttctcgct gcccgcgcct gcctccgttc gggagtaggg
     1201 ttgctgactg ttcatgcacc aatgtgcaac aacgacatct tgcagacctc catccccgaa
     1261 gcaatcgtag aaaccgacat caacgaaacc tgttttgccg tacctaccga cacggacgac
     1321 tatcaagcag tcggcatcgg cccagggctg ggacgaaacg aggaaacgga agctgccttg
     1381 ttggaacaac tggaacactg ccagactcct gttgtagtgg atgccgacgc acttaatatc
     1441 ctcgccaacc accgtcatgc acttacccac ctaccgaagg gttccatcct caccccgcat
     1501 ccgaaagaac tggaacgtct gaccggcaaa tgccaggact cttacgaacg tctgatgaag
     1561 gcttgcgaac tggcccgtgc cgcccatgtt cacattattt taaaaggagc ctactccgcc
     1621 atcatcaccc ctgaaggtaa atatttcttc aacccaaccg gaaatccggg aatggcaacc
     1681 ggaggtagcg gtgacgtact gaccggagta atcctggcgc tgcttgccca aggttacccc
     1741 accgaggaag ccgctaaaat cggcacttac attcacggat tggcgggcga tgtcgctcaa
     1801 aagaagcaag gaatgatcgg aatgatcgca agcgatatta tcacctgtct gccgacagca
     1861 tggcgacttg taagcgaata aaagttaaga agttaccctt ttttcaataa cttcattaac
     1921 tttgttttca aaaccagtta aaaagaaccg aatatgaaaa agttgattat agcagcagga
     1981 ctacttatga caacgtccgc ctatgcacaa accgaagtac tgacgggggt tacccgagga
     2041 aaagactatg gagtggttta cagtcttccc aaaacccaaa tagaacttga aataaaagcc
     2101 aacaaagtca actatactcc gggagaattc agcaaatatg ctgatcgtta cctacgactg
     2161 accaacgtct ccgccgaccc tgaagagtat tgggaactag ctagcgtaaa agtgaaatcc
     2221 gtaggtgtgc ccaacagcga aactacgtat ttcgtaaaat tgaaggataa gacagtagca
     2281 ccgctcatgg aactgacaga ggatggcatt gtgaaaacga tcaatgttcc ttacagcaat
     2341 agcagtgtag gcaaaaaagc tgctcccgcc cccgcagtcc tccaaaagaa agcgaatcct
     2401 cgcgaattcc tgaccgaaga gattctgatg gctagttcta ccgccaagat ggccgagctg
     2461 gtggctaaag aaatctataa catccgcgaa agcaaaaatg ccttattgcg cggacaagct
     2521 gataatatgc cttcagatgg ggcacagctt aaaattatgc tcgacaatct gaatgcacag
     2581 gaagaagcca tgacgcaaat gttctccggc acctgcaaca aagaagagag aacattcact
     2641 gtccgcctta cccctgacaa ggaattcaac aatgaagttg ccttccgctt ctcgaagaag
     2701 ttaggtgtag ttgccaacaa tgatttggca ggaactccgt tttatatcag tctgaaagac
     2761 ctgaaatcgg tcaagatacc acaggaagac gataagaaga agaaagattt ggatggaatc
     2821 gcctacaacg tacccggaca agctatggtt acactgaccg acggtaaaaa gaaactttac
     2881 gaaggtgaac ttcctattac tcaatttggt gtgatagaat atctggctcc ggttttgttc
     2941 aacaagaatt ctaccatcaa agtttatttt gatccgaata cgggaggatt gctcaaagtg
     3001 gacagagaag aagggaaata gaaaaatgag gaagtgaact tctaaaaaac aaagaatatg
     3061 gttggtgaag gacatgcatt cgacatgata cgccgaataa aagagggacg ggaagcttcc
     3121 cgcctacgtc gtgaacgtgc taacgataag ttgaagcatt taaaccgtgc aaacgaacct
     3181 tatccactac ccaacaccac ccccgaagaa atggaacgta tcatccacga ctcggagaaa
     3241 aagaaagaga aagacagcaa ttattttgtt tggggaacgc ttattatcat gggggtcctg
     3301 atagcaattg ccgtcatact ttgggctgta tttatcaaat aaataataat aagttcctat
     3361 atacgactgg tatcaccagt tttataaatc catctttctg catttgagaa agataagccg
     3421 atacacgcga ctcgtagccc tcttcatttt gaaagtggtc tgcgagtttt tctataatct
     3481 cacgaacatt gcgttttcca tctatcagtt cccatacagc cgtaccgtgt tcttccaatt
     3541 tcacatgaag ttctttcgac attcctttcg gcacaaggaa gcgttgcatc cacggatatt
     3601 taaaacgggg aaaggagagc acaattgtct ccccttccct ttctgctgta atatgttcac
     3661 tgcgacaggg aatgacctct aacaggttga ttttctcttt ggcagccata cttcttattt
     3721 tttatttcag agtattcata ctgataccct tttgtttaca ccttgataca aaattccttt
     3781 gttactttag gtattgaatt tcctagttac ttttggatat tcgcctcttc cagaccgtat
     3841 cccttcttct tgttctctgc ctttaacatc aaagccacaa tcagagcaag cacaccaaag
     3901 agagcaaaaa tagccatcgg caacgtgtag tcataagtct gtgcaccgtc tactaccgga
     3961 cctttgcaat aagtattcaa cacccatccg atcaacaaag gaacacccat caatccccag
     4021 ttctgtaccc agaaaatcaa tgcgtatgcg gtacccaact gtttttccgg aataatcttc
     4081 ggaacagacg gccacatagc tgaaggcacc aacgagaagg caaatcccaa tataatcatg
     4141 atgatagtag caaaccacca tatattcagt ataggcagag cgaatatcgt atgcacaaaa
     4201 ataagcatca ctgatccgat tatcatcaac gtagctccct taccgatacg gtcataaagc
     4261 gagccgaaca acggagtcag gataatcgca ccaatcggca acaatccggg aatcgttccc
     4321 gccaacttcg gatctacatt atacttctgc accatcaagt cggcagcata cttgataaag
     4381 gggaatacag ccgagtagaa caatacacat agtaatgcaa tcaaccagaa tcccttattc
     4441 gtaatgatat acacaatatc tttcatacgg aacggttctt ccggttccaa tccctctgca
     4501 tccaaagaag catccaactt cttatcatag aaagtataaa ggaagaaagc aatcgtaccc
     4561 acgcacaaca taatcagaca aaacaaaatc ggagcaggaa tattggtatg gaatgtgcca
     4621 ctctcatccg tagatccgaa gaagtcggcc aaaggaaccg tgagcaccat tgccagagtt
     4681 gttccgatac gtgccgtagc catttcaagt cccatagcca atgccatttc cttacccttg
     4741 aaccatttta caataatttt ggaaactgtg ataccggcaa tttccacacc tacaccgaag
     4801 atagcatacc ccaatgcggc cagggttacc tgtgttttga atccaaagag catggcacct
     4861 tccggaaaag tagtagaaat cgcatagtat ttcaatccac aaccaaacac catcaataag
     4921 caagccccca ttccggtgaa acgaactccc atcttatcca aaatgatacc accgaaaatc
     4981 agcatcaaca ggaatacatt aaaccacccg taagcgcttg tgaagaaacc ataatcaaga
     5041 ctgtcccata gtagttcttt ctcaagcatg ggttttagag gagacattac gtcggtgagg
     5101 aaatagccgc atagcatagt aaatgcgacc aatgctagaa cactccatcg gagtacggcg
     5161 gagtcattca atttctgttt caaatgttct gtcattgtta tatttaaaaa agtagttaat
     5221 aatcttcata cgaccaacaa aggtagttaa atctcgtttg tttctatcaa aaagagattg
     5281 tttttacaag aaaaagttaa gtgcggatta cactgaccac gcggaagatt gaaaatccgt
     5341 gtaatctgcg taatccgcac ttaaatatca aagaaatgca gcatccgtct gcaccttccc
     5401 attaatggtt ttaccccaaa gtcttacctg acaacggagt gaattactct gctgcaggag
     5461 caggagtttc agtagccggt gccggagttt ctgtagcagg tgcattggta gcaggagctt
     5521 cagtttgcgg cgcagccgta cctgcgggta agttatacgg gttagtctgt tgttctttct
     5581 gtgcctgttc caacactgcg tctttagcaa cagcagagcg aggaactaca taagcagtag
     5641 caatgctcat taccaccatg aagatagcta agccccatgt tgctttttcc agaaaatctg
     5701 tagtcttgcg cacgcccatg atggcgttag atgaagagaa accagaagca agtccgcctc
     5761 cttttgagtt ctgaatcagc acgatgaaac acatcaacaa ggctgcaata accattaaga
     5821 taacgaataa taagtacatt tttagttatt ttgaattagc gttaataatc aatttctcca
     5881 aaaatctgat ttggtctgca aagtaagcat ttttttttgg atatttcaag cttaattttt
     5941 taattatttc aagagctttt gaatatcgtt gctgtttaac atagattttt gccaaagttt
     6001 ccgtaaaaca gctgtcatct tcctcttctt ccttcattgt ttcttcttcg gtaagttcgt
     6061 ccgaagaggt tggcgaagat ggcatttctt ctcttaaagg tttcttgcag aggggagagt
     6121 cgctctcgct cttttctata aagtcgtcaa tcagttcgta gcctttgagt ttgggcgttt
     6181 cttcggccga ctgttccgtg gccggagtct cctccaaaag ataagaggtg taatccatcg
     6241 aatagtcgaa gctggtgcgg gcagtcacct cttcgggtac tgtggacaag aaagcgtcga
     6301 tcaatgctaa tgtgcggtct acggacggtt cgtctttcag cacctccgtg agaggtactc
     6361 cctttttccg tgcctgcaca tcatagcggt caccttcaat caaccggaac aactgccgtc
     6421 tgtctgcaat gtaaagaact gctttccgca gttctccacc gaaactaata tcatggagaa
     6481 tatacagatt cttcagatac agcagacgaa gtgactgaaa atacggatac ctcgcaagaa
     6541 gattgcgcag ttcgtacaaa gtatccctat tcagcgtctc gggatgctga atccattgtt
     6601 gaaagttaac agaagtcatt tatattacca gtttgctaca gttgcattaa aaatttggtc
     6661 ggtgatctct ttagacattt cagcaatcaa tccgtcctgt acggcagtca gcaactggct
     6721 agagtcgtag gtacggaacg cagaaaactg ttgttcaaag tcttcggcat gattggtgtt
     6781 gttgacaaaa cgtacattga cggtaatagt caacttcgtc tccgaagagt aaccgtcggc
     6841 agatactgcc tggttgtact gattgtatcc tgtgatttct ccgtcaatct gcaagtccgc
     6901 attctgattc ggcttgagca gttgcagacg ggtctgccgg atgaagatat ctttcaggtc
     6961 ctcattgaat ttggttgcta acggagcata tacatactcc gacttgatcg ggaagtcggc
     7021 tatcgaaatg gtctttacct tatcataatt gatagacgat ccgttaaact tataggaaac
     7081 agtgcacgca atgactacca acggcaagcc gaacagtaac aaagggcgta ttattttctt
     7141 aatccaattc atattctttt atttttctat aaagtgtacg ctcggaaata ttcaagtcct
     7201 tggccgcact cttccgcttt ccatgatgcc tctcaagtgc cttgcgtatc atttctttct
     7261 ccacttcgtc cagtgacaaa ggggattctt ctacatattc ttccgtgtct tgtatgtcat
     7321 catcatcctt gcaaaccgta ggctgcatgg tgtgaatgat agcaggtacc gaaggttgat
     7381 gcgccgtcac taccggagta gtaaccaccg ttcccatttg tcctacctgc cccacctgtc
     7441 cggcacgttc cgccatcagg ttgtgcacca tcttcttcag ctccgccact tcctggcgca
     7501 tatcgaacag aacagaataa agaatctccc gttcgctctc aaagccttta ctctcacgcg
     7561 ttcccatcaa cgcgggaaga cgttgcgtat tttgtgcagg aagataattc tgcaagatag
     7621 cagcagagat ctccctattg gtttcaatga tagatatttg ctcggtgatg ttcttcaact
     7681 gacgcacgtt tccgggccac gggtaagcca acaactcttt cttcgcatcc tccgtcaact
     7741 gaatagcggg catccggtat ttctctgcaa agtctgcgga aaacttacga aacaacaaaa
     7801 gtacatcgtc accacgttca cgcaaaggcg gtatctggat aggcaccgta ttcaaccggt
     7861 aatataaatc ttcacggaaa cgtccttctg caatcgcttg tgtaagattg acgttggtag
     7921 ccgccaccac acgcacatcc gttttttgta ctttggacga acctactttc ataaactcgc
     7981 cactctccag tacacggagc aaacgtgcct gggtagacat cggcaactcc cctacttcat
     8041 caagaaaaat agtaccaccg tcagcttcgc caaagtaccc tttccgttcg ccaatcgcac
     8101 cggtaaacgc acctttctca tgtccgaaca gttcggaatc aatcgtacct tccggaatag
     8161 cgccacagtt gacagcaata tactgtccgt gcttcctccg gctatattga tgaataatct
     8221 gcggaaaact ttcttttccg actccacttt ctccggtaat cagcacagac aaatcggtag
     8281 gagctacctg aatggcaaca tctatggcgc gcgacaatgc ttcagtattt ccaataatac
     8341 cgaaacgctg tttcacttgt tgtatctctg ctttcgtcat cactcgtttt taatcttcgt
     8401 ctactgtatc cagcttcagt ttatcactat cgtcacgttt ctcgtaatac tgtttacgca
     8461 acggattggc acgagccact ttttcccgct gacgattacg gaacacgtcg atggcaacat
     8521 agattgcctg acggaaagaa tcttcacaag ccactccctt gcctgcaata tcgtatgccg
     8581 ttccatgagc cggagaagta cgtactaccg gcagtcctgc cgtatagttc accccgtctt
     8641 ccatagccaa ggccttgaac ggagccagcc cttgatcgtg atacatcgcc aggataccgt
     8701 caaaatgagt ataattgccc gaacccataa agccgtcggc cgcataagga ccgtagcaaa
     8761 ggattccttt ctcttccatt tctttcatgg cagggataat cacttcctgc tcttccattc
     8821 ccaacaaacc accgtctccg gcatgaggat tgagagagag caccgcaata cgcggagcgc
     8881 cgataccgaa atcctgtttc agacaacgat ggaatatcat cagtttctcc tgaatcaatt
     8941 ctttggtaat cgtagtcgca atctctctaa cagggatatg tgtcgtcacc aaagccaccc
     9001 ggaagtcatt cttcatcaaa atcatcaatg acttatcacc attgcccaga cgttcttcga
     9061 tatattccgt atgtccgggg aaggagaact cttccgactg aatcgtatgt ttgttgatcg
     9121 gagctgttac gataacgtct atcaaccctt cgcgatattc ttcgatggca cgttccaaag
     9181 cccccagcgc agctttaccg gcttcggggt cgggtttgga aaattccact ttcacctcat
     9241 catccgtaca gttcaccacg ctcaaacggt tgtaccccgc ttcggtagca gagttgacaa
     9301 tgctgaaatt ggcctgtata tccagtgctt tgcgatgata agccgctact ttcggtgagc
     9361 cataaatgat cggagtacat agttccaaca tcgtagggtc ggaaaatgtc ttaagaatca
     9421 cctcatagcc caccccgtta atatctcctt gggtgatacc tatccttatc ttgttatctt
     9481 ccatgttttt atttattagt ttgttccgct tccttagatg cttctcccaa tggaatctgc
     9541 ttctgctgaa cttcattcgg aagtttcagt gtatacagag atgcttccat ctggcgtact
     9601 aggttgcgtt tcattttatc aggtgaataa acaaatattt ctgcagtaat aattcgttgg
     9661 ttcttctcgt ccagacgagt atgagataca tacggaccac ccataaagtc gcccttcata
     9721 cgccacagac cacgtgcttc cattgtgtag ctgttctgta cattgatcgg acggacatcg
     9781 gtcagtaaac tatcggtcga catataaact ccttccttga atccggggat attggctttc
     9841 atcacagagt cacgtttgtg cacaaaatat tctttggtaa acgtatcctt gtcagtgtac
     9901 ggataagagt acatcacaaa gttacggtcg gcagtacctg tgttggtaga agcccagaag
     9961 aaatcatccc cggtctttga attagccagt tcggcatcca cccagatgtc gcatccgaac
    10021 aaactgtcca ctttctgcga aatgaaatta ctgtgtttcc cttccaggaa tgtaatctga
    10081 cggttcattt ccgcacgggt aaagaagtcg acaatcgtct ttttgttctc ttccacaaac
    10141 ttctcgaact cttcttcgtt cggagcctgg atagtcaata tcatctgcgg attggcatac
    10201 acgtccttcg catatttgaa cgaggctttc gtatatatat cctgtatatc tacaataata
    10261 atgttacgta tcaacttcag cgtagaatca taatctttcg gcgaagtata cataatccgg
    10321 aaagaaggtt ccgactgcgg caaaccgggc atatcagcat cgagcgcatc atgtaaagcc
    10381 cttccggcag cacgatccca aacaccgtga tctactacaa ccaaaagctc gtaagcacga
    10441 ccactagagg tgtgatttcc tttcagacca caagatgcaa cgacaaaggc taccaaagcg
    10501 atgcataaaa taaaagagta ctttttcatg atgttcggtt ttatatatta actttcatta
    10561 tttttctcct gtttcgctgt cgacagcata ccgcaagcgg caaaaatatc ttcgcccctg
    10621 gatgaacgga tagtggtgaa aagtccgtgt gacgtcagat aatcacgaaa acgggtcatc
    10681 gtatccatgt ccgccccctc gaggtctacc cccggtatgg catgaaaacg aatcagattc
    10741 accctgcaat ccagcccgcg aagaagtttc agcaactctt tggcatagac ctgcgaatca
    10801 ttgagccctt taaaaacaat atattcaaac gaaagtcgac gttgtttact aaaatcatag
    10861 ttttttaaca gttccaccat ttcggtgatt gaaaacgcct tttccgccgg cattaattca
    10921 gcacgctgaa cggtcagcgg agagtgaagg ctgatggcaa ggtggcagtc attttcttca
    10981 ataaaacgct gcaatccttt ccgtagcccg actgtagaaa gcgtgatacg cttcggactc
    11041 catgcgtaac cgtaggtagc ggtcagtagt tccaatgcct tcaatacctc atccaggtta
    11101 tcgagcggct cgcccattcc catcattacg acattagtca gtttgtcccg ttccggcagc
    11161 gaatgaatct ggtttatgat ctggctggcg gtcaggttag ccgtataccc ctgtttgccg
    11221 gtcatacaga acttacagtt catcttgcaa cctacttgtg acgacacgca caacgttgcc
    11281 cggtcatcat ccggtatata aaccgactct acaaaatggt tctcacccac tttataaaga
    11341 tacttcaccg taccatctac agagcgcatt tcatctaccg gagcttccgc tcccacctca
    11401 tagttctgct tgagcaactc tcggtgtttc aatgacaaat tagtcatatc atcaatcgag
    11461 gctaccttct tttcgtaaag ccaggatgca atctgcttgg cagcaaagcc gggcataccc
    11521 agtctttttg tcaatgattg aagctctaca agagtcattc ctaaaagggg atatttagac
    11581 attcttcttt ctgttgatag tttatatctg caaatgtaag gaaataaagt cgatttccgt
    11641 atagcaggaa tgtaaaagtt aacaaaaaag ggaagtatgc ctccgttatg attcaaccac
    11701 gctgatatat tgaagtagct tttgcgccat ttcagaatcc tcgccattct ttttcacttc
    11761 ataaccgtac gcctcacgga aacaagccag cgcctcttcc cgttcattac aaaagctgtg
    11821 caaaacccct aagttctgac aagccagaat cgtatcttct tcctcccatc ccaaatactt
    11881 ctttcgcagt tcaagctctc tgaagaaagc ctctttcgcc attggataat tctccaactt
    11941 cacataagcc tgtgctttgt aataatatac cagacaggaa gcattagggt cagcatcatc
    12001 gtgaaaatcc aaagacgttg caatacgaat cacgttatca tagtctttat tcatgtaata
    12061 ctgctgcata atatcacatc tcaatgcctc gtagcggaca gtcagttccg ccagacgcgg
    12121 tttttcgctg aaatacattt catgcagaag agactcacgg aagaataaag tagacgcctg
    12181 ctcatcgcca cgttcattca tcatccgttt gaattccctg catagataat acaactgttt
    12241 atgacaagcg acgatctgtt ttttgctgtc tatctgtata gcaatgtcca acgcctgatt
    12301 catcagcatc catgcttcat cgtatcgttt gatataataa agacatttac cctgcatacg
    12361 caaacattta gccactccac cagacagtct gccattcaac gactcgtgca tttcagctac
    12421 tttccggaat ttctcggcag ccctctcttc ctcatcctta tagtaatcac aataagccag
    12481 atattcggaa agttcaatga cttctgcctg actcttctca tcagcagaag ccgcatgata
    12541 atcaagcgcc ctattcagat aggtcactgc ttcattgtat tgctcattgt agtaatatgc
    12601 cagagctaga tttcggcaag tgttggcaat ctccagttcc ggagtcggta caatgttttc
    12661 ctgcatcacc aatgctttca ggaaacagtc gcatgccgtt tcgtattctt cattacgggc
    12721 ataccggcat ccctcattca tcttcaatac cgacttggca atgagtggca tggcagcacc
    12781 ttccatactc ttctcactca cagcagctgc cgccttcgtc agatggaaag aactgctcaa
    12841 gaaagtagcc atatcattag caatgacagg aattaaaaaa gaatcgatct catcaaaatc
    12901 caattcggca tagacttcag gcgtaacttc aggattgtcg ttcatgatcg ccttccagct
    12961 atcttccaac agagaacgat tcgtgcgata cagaatctcg aaaatctcca catcacaaat
    13021 ccaatccttc aatatatccc attcttgcat cttatagcat tgataggtaa tctccacttt
    13081 atagcgatac gaatcatggt agcagaactg tttcatgcga tagttataat cggcaaaagt
    13141 caacggatgg gaaaggatct cttcctcatc cagcagagcg gaaataattt catggcgact
    13201 atcatctata cattcgtcat cttgagcgaa atagcgttcg attgcctcta ccatttgtgt
    13261 gtcaccaatg caatatcgcc ctcctttgtt agtgagccag ctgctcattt ccactctcaa
    13321 ctgcgaccaa agtatctgat taatgtctgc catgctcttc acttcatctt cggtaaatcc
    13381 ttctaaagta agtgaaagca tcagaagcgt tcttccaatc tcttcgaaac cataatcagc
    13441 cgacaaacgc cgtagcacac tgtcatagaa ttgcccaacc tcattgagcc ggcaatatcc
    13501 actcatatat tcattgagag catcgtactg accgaacgaa accagctcgt tgagcaatac
    13561 acttaaacag cgcggttgtt tagccagcac ccacgaagca agaatatctt cctgttgtgc
    13621 ggacaaagcc ttggagtaag tagacaaata ttgctttgag aacgacttgg catccgcctg
    13681 tgaaaagcca ttcaactgga aatgggcgt
//
