LOCUS       c00108_gnlPro..        16735 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IPLCELAE_108.
ACCESSION   c00108_gnlPro..
VERSION     c00108_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 11:42:20
            Original ID  :: gnl|Prokka|IPLCELAE_108
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16735
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16735
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4671:8220](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4672..8220
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16735
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16735
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             529..2085
                     /locus_tag="ctg108_1"
                     /transl_table=11
                     /translation="MNDLLRKLPIGIQTFEKLRKGDYLYVDKTELVWKIAYTSTPYFLS
                     RPRRFGKSLLLSTFEAYFEGKKELFEGLAIEKLETKWEKHPVLHLDLNAEKYDSPERLY
                     DILSRQLTLWEIQYGKGIDENTLSGRFSGVIRRAYEQTGSSVVVLVDEYDKPLLQALGN
                     DVLLDEYRKTLKAFYGVLKSADRYLRFVFLTGVTKFSQVSVFSDLNQLQDITLWPDYGT
                     LCGITLQELLDTFQPEIKILAANNSISYDDAVQRMTRLYDGYHFCINSVGIFNPFSVLN
                     VLKSKVFDNYWFQTGTPTFLVEMLQETEYDLRTLLDGIEAPSSMFSEYRVDSNNPIPLI
                     YQSGYLTIKDFDREFGNYLLQFPNDEVRYGFINFLVPFYTGVRNSDQGFYIGKFVQELR
                     SGDYDAFLTRLQAFFADFTYELNEQTERHYQVVFYIVFKLMGQFTDAEVRSARGRADAV
                     VKTPKYIYVFEFKLHDTAEAALKQIDDKGYLIPYQADGREVIKIGVEFSAEKRNISRWL
                     V"
     CDS             complement(2096..3298)
                     /locus_tag="ctg108_2"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARRMASELALLPMWYA
                     EEGSAVLASSAYNLDYLKQMQELLGVSIHLMTEPELAVGPDLDIRPWGWDVALRKRLLG
                     LGVDEALLPSMEQLNGLREYSHRSKAVSLLPELQLNEYFCGESYYLKTQEEWKTFVEER
                     ECCLLKAPLSGSGKGLNWCKGIFTPFISGWCTRVAASQGGIIAEPIYNKVEDFAMEFYS
                     DGTGEVTFMGYSLFHTGKSGMYEGNRLFSNEAIWKQLSQYIPSKVLTDLENCLKYRLSA
                     LVGTVYKGYLGVDMMICRFLENEKPVFRIHPCVEINLRMNMGVVARFLYDRYVRSGSTG
                     RFVIDYHPSEGEALQEHERMSATYPLEIREGRVYSGYLPLVPVHRRSCYRAWIWVTPDN
                     I"
     CDS             3461..4639
                     /locus_tag="ctg108_3"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             4672..8220
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg108_4"
                     /sec_met_domain="PFOR_II (E-value: 5.5e-19, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 6.4e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 8.8e-32, bitscore: 100.0,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.3e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.5e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.8e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.4e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGAE"
     CDS             complement(8373..9239)
                     /locus_tag="ctg108_5"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAILLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRQLVDSW
                     IPKSENK"
     CDS             complement(9260..10084)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg108_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.4e-29, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMVHFSTFFDAVNAGIGSFIIGFQHVLFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(10081..11307)
                     /locus_tag="ctg108_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGHEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTAGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSRQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETHEFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(11607..11945)
                     /locus_tag="ctg108_8"
                     /transl_table=11
                     /translation="MKDYKVDKASLSTSFCQEVYQVVREIPVGKVSTYGGIAALLGMPQ
                     CSRMVGRALKQVPDDLSTPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVSE"
     CDS             12028..13416
                     /locus_tag="ctg108_9"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGV
                     FAFSSCEKNLYDESKQPEKEIQVKDLDIPAGFQWKLTQVAAGTVAATTPTMVSFFLDEA
                     CSKEEKIADIPVDTEISSLPLSIPTYVNTLYAQYKTSTNETKKVAIPVNADRSFSLNIA
                     NDAKSKSNTTRSITRGHDIEDDIQLSKGVIFHPKDGWGTIMFEDQFPSLGDYDFNDFVV
                     NYKVQFQGIRKVDKKYTAQYIQIGLRLKAIGGIFPYSPYLRLKEIDSDEVESIEVYETK
                     NVIPAIDGVELVPNKHLIIDYSPLIKNLAKPAGSQYYNTEKNALVATSDLPEINILITL
                     KKRKEVKEILEGDEFDLYLKRNDSGTEIHMNGIEPITYQYPFNDKNLLPIYTNGDEEDD
                     NYYFSAGRLIWGLRVPGNAAHAIEKANFLEAYKGFAKWAQSSGKNEQNWYNQGNADKSL
                     LIHN"
     CDS             complement(13497..16334)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.6; E-value: 2.6e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg108_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 4.3e-20, bitscore:
                     61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRMMGYTKWIAVLLCLLGMTACRQDTHRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDEGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNFPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKVGREKEMIFVGIDALPGKGNGLEMVLDSVLNATFIYPTNGDKVMQLAMN
                     ILEKKPYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRAKNRLNKELSEQKKQLEEQRDKLEEQRDQLEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADHTLSGDQH
                     RMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVQIDVLSSFEGWNESFLAAARKKH
                     IHFSFDNMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKITVRLSSLTKEDTRWIR
                     FTVANTGSMISAEHIRSIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTISVESDEKQG
                     TVFTVDLPVQTCETILAEDSLKSSISAVPLNPASPGSPASSDLNGTLAAEEEELEKGYD
                     SSKPSVLVIDDNADIRSYVRGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGI
                     DGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRN
                     LIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKTLIEAKMGDSNLNVEDLGKDMGLS
                     RVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCYR
                     EQFGESPTDLLKRKG"
ORIGIN
        1 taaattaacg gcaggagaaa caaattacat gtcactatta cctatcaaca ataataaaga
       61 atactaatta ttggataaag agatgctata tactccacta cagagtatag aaaaagggac
      121 agccatacaa tgagtgctta cttttgcact catggagaat tagtttatgt aaggtttata
      181 ctgtgttgca gatactttat ctgcaaccta tctgtcgcag gtatctgcca cgttctaact
      241 acttattaac tactgtatta catgcgtttg gttgcaggtg gcagatgttt tcatgttttt
      301 tcaactttat agaggaggat tacgcattaa aattagggtc acaaccgtaa gtcataaaac
      361 aaattcacct ctgtgtcctc cgtgtcctct gtggtgaaaa ccgtgcaaga atgagctaaa
      421 tgataatttt ccagttaaac aaaattataa cgcccgttct ttgagatatt gaaaacgaaa
      481 tattacgaaa ataatgatta tctttgaacc actaaaagga aaataacaat gaatgacctg
      541 cttcgtaaac tccctatcgg gatacagacc tttgagaaac ttcgtaaggg cgattatcta
      601 tatgtagata aaacagagct tgtatggaaa atagcttata catctactcc atacttcctg
      661 agtcgtccac gccgttttgg taaaagtctt cttctctcta cctttgaagc ctactttgaa
      721 ggaaagaaag aactcttcga agggcttgcc attgaaaaac tggaaacgaa atgggaaaag
      781 catcctgtgc tgcatctgga tttaaatgcc gagaagtacg attccccaga aagactttat
      841 gatatcctca gccgtcaact caccttatgg gaaatccaat atggcaaagg aatagacgag
      901 aacactcttt ccggtcgttt ctccggcgtc atccgtcgtg cctacgaaca aaccggtagc
      961 agcgtcgtag ttctggtaga cgaatacgac aaacctctat tgcaagcttt aggcaatgat
     1021 gtcttactgg atgaataccg taaaactctg aaagcctttt acggagtatt gaaaagtgcc
     1081 gaccgctacc tacgtttcgt cttcctcaca ggagtaacga aattctcaca agtaagtgta
     1141 ttcagtgacc tcaaccaatt gcaggacatc actttatggc ccgattacgg aaccctttgc
     1201 ggcatcactc ttcaagaatt attggatacc ttccagccgg aaatcaagat actggcagcc
     1261 aataattcca tttcttatga tgacgcggta caacgaatga cacgtctcta cgatggctat
     1321 catttttgca ttaattcagt aggtatcttc aacccgttca gtgtactgaa tgtcctgaaa
     1381 tcaaaagtgt tcgacaatta ctggttccag accggcacac cgactttcct cgtcgagatg
     1441 ctgcaagaaa ccgaatacga cctgcgtact ttgcttgacg ggatcgaagc accgtcttcc
     1501 atgttctccg aatatcgtgt agattccaat aatccgattc cgttaattta ccaaagtggc
     1561 tatctgacga taaaagattt cgatagggaa tttggtaact atctattgca atttcctaat
     1621 gatgaagtcc gctacggctt cattaatttc ctggttccat tttacaccgg agtgagaaac
     1681 agtgaccaag gattttacat cggcaagttt gtacaagaac ttcgttcggg agactacgat
     1741 gcctttctta cccgcctgca agccttcttt gccgatttca cctacgaatt gaacgagcag
     1801 acagagcgtc actaccaagt agttttctat attgtcttca aacttatggg acagttcacc
     1861 gatgccgaag tacgcagcgc ccgcggtcgt gcagatgccg tagtgaaaac acctaaatat
     1921 atctatgtct tcgaattcaa gctgcatgac acagcagaag cggcattgaa gcagatcgac
     1981 gataaaggct atctgatacc gtatcaggca gacggacgtg aagtgataaa gatcggggta
     2041 gagttcagtg cggaaaaacg caatatcagt cgctggctgg tgtgaacaga taaagttaaa
     2101 tattatcagg agttacccat atccatgcgc gatagcaact tctcctatga acaggaacca
     2161 aaggtaaata accggagtac actctacctt ccctgatttc caacggataa gttgcggaca
     2221 ttcgttcatg ttcctgcaag gcttcacctt ccgaaggatg ataatcaatc acaaaacgcc
     2281 ctgttgaacc agaacgtaca taacggtcat ataaaaaacg cgcaacaact cccatattca
     2341 tgcgcagatt aatttccaca cagggatgaa tccgaaaaac cggcttttca ttttccagaa
     2401 accgacaaat catcatatca actccaagat aacctttata aacggttcct accaacgcag
     2461 aaagcctata tttcaagcag ttctccaaat ccgtcaaaac ctttgaaggg atatattgcg
     2521 aaagttgttt ccagattgcc tcattagaaa acaaacgatt cccttcatac attccactct
     2581 ttccggtatg gaagagggaa tatcccataa atgtcacttc acctgtacca tcggaataaa
     2641 actccatggc aaaatcctct accttattat atataggttc cgcaatgatt ccaccctgcg
     2701 aagcagccac acgcgtacac caaccggaaa taaaaggagt aaatatgcct ttacaccagt
     2761 tcaagccttt accgcttccc gaaagcggag ctttcaacag gcagcattcc cgctcttcca
     2821 caaaggtttt ccattcttcc tgtgtcttca aataataaga ttctccgcag aaatattcat
     2881 tcagttgtaa ttccggaagc aatgagacgg ctttagaacg atgggagtat tcccgcagac
     2941 cgtttaattg ctccatagaa ggaagcaggg cttcgtccac gcccagccct aaaagccgtt
     3001 tccgcaaagc tacatcccac ccccaaggac gaatatccaa atccggtccg acagcaagtt
     3061 ccggttcagt catcaaatga atcgaaactc ccagcaattc ctgcatttgc ttcaaataat
     3121 ccagattata agcggaagaa gctaatacag cactcccctc ctctgcatac cacatcggaa
     3181 gcaaagccaa ctcggaagcc atacgtctgg ccgaagctgg agccatataa ttagtttcac
     3241 cgctggccaa cgccaagtca tgttccggat tgaatatata aagagccttt tttgtcattt
     3301 caaatgaatt caaaacttta ttctgcaaat atatacagga aatagtcagg aatgactaca
     3361 ataaacagaa agttggaatt aaacacacaa ttttgccatc tctactttgc aaatcctaaa
     3421 aaaagcagta tatttgccac ccgaaaaaca aagaactgaa atggaatcat tctaccgcac
     3481 acacgcctac ctcgttgagc acaccaatgc ccccgttcgc cgcgatctta tggacgagat
     3541 cgattggagc gaccgcctga ttggtatcaa agggacacgt ggcgtaggaa aaaccacttt
     3601 ccttctccaa tacgccaaag agaaattcgg gaacgaccgt tcctgtctgt tcatcaacat
     3661 gaacaacttc tatttctcgg gccacagcat tgtagacttc gccaacgaat ttcagaaacg
     3721 tggcggaaaa gtattgttga tcgaccaggt gttcaaacat ccggaatgga gcaaagagtt
     3781 acgcatgtgt tacgaccgtt ttcctaacct gaaaattgtc ttcaccggct cgtccgtgat
     3841 gcgactgaaa gaagaaaatc ttgaattacg tgatatcgcc aagagctata acctgcgtgg
     3901 attctctttc cgtgaattcc taaacttgca aacaggcatg aaattcaggg catacagtct
     3961 cgaagaaatt cttagcactc acgaacagat tgccaaagga gtactctcca aagtccgtcc
     4021 gttggattat ttccaggatt atctgcacca cggcttctat ccgttcttcc tcgaaaagcg
     4081 taacttttcg gagaatctgc tgaaaacgat gaacatgatg gtggaagtag atatacttct
     4141 catcaaacaa attgaactga aatatctttc aaagataaaa aaattactat atttgctcgc
     4201 tgtcgacggg ccgaaagctc caaatgtgag ccaactagca agcgacatac agacatctcg
     4261 cgccacggtg atgaactata tcaagtatct ggcagatgcg cgactcatta atctggttta
     4321 tccgaaaggg gaagaattcc ctaaaaaacc ttcaaagata atgatgcaca actccaacct
     4381 gatgtattcc atctatccgg tgaaagtgga agagcaggat gtgctcgaca cattctttgc
     4441 aaattcttta tggaaagacc ataaggtaca taaaggagat aaaaacgtct cttttatggt
     4501 ggacgaagta atgccgttca aaatttgcca ggaaggcgca aagatcaaga acaatccgaa
     4561 tgtaacgtac gcgttgcata aggctgaaat aggtcggggc aaccagatac ctctctggat
     4621 gttcggcttt ttatattaaa agatttattt acttaaatat ttaatttagt tatgactaaa
     4681 cagaagaaat tcatcacttg tgatggtaac caggctgcag cgcatatctc gtatatgttc
     4741 tctgaagtag cagctatcta ccccatcact ccttcttcga ctatggctga gtacgtagac
     4801 gaatgggctg ccgcaggacg taagaacatc ttcggcgaaa cagtattagt acaggaaatg
     4861 caatctgaag gtggtgctgc cggtgcagtt cacggttctc ttcaggctgg tgcgttgact
     4921 actacttaca ctgcttccca aggtcttctc ctgatgatcc ctaacatgta caaaattgcc
     4981 ggtgagttct tgccttgcgt attccatgta tctgctcgta cattggcttc tcacgcattg
     5041 tgtatcttcg gtgaccacca agacgtaatg tcagctcgtc agactggctt tgctatgttg
     5101 gctgaaggct ctgtacagga agttatggat ttggctggtg ttgctcactt ggctaccatc
     5161 aaatctcgcg ttccgttcat gaacttcttc gatggtttcc gtacatctca cgaaatccaa
     5221 aagattgaaa tgttggaaaa tgatgatctt gctccgctga tcgaccaaga agctttggct
     5281 gaattccgtg cccgcgcact gaacccgatg aaaccggtag ctcgtggtat ggctgaaaat
     5341 cctgaccatt tcttccaaca tcgtgaatca tgcaacaact actatgaagc agttcctgct
     5401 atcgtagaag aatacatgaa tgaaatttct aagatcacag gtcgtaaata cggtttgttc
     5461 gattactatg gtgcagaaga tgcagaacgc gtaattatcg ctatgggttc tgtaacagaa
     5521 gctgcccgcg aagctatcga ctacctggta gcaaacggcg aaaaagtggg tatggttgcc
     5581 gtacacctgt atcgtccgtt ctctgctaaa cacttcttgg ctgctgtacc taagactgct
     5641 aagactatcg cagttcttga ccgtactaaa gaaccgggtg ctaacggtga acctctttac
     5701 cttgacgtta aagactgctt ctacggtgca gaaaatgctc cggttatcgt tggcggtcgc
     5761 tacggtttgg gttcaaaaga tactactcct gctcaaatcc tttcagtatt cgaaaacttg
     5821 gctatgccaa tgccgaagaa ccacttcact atcggtatcg tagacgacgt tactttcact
     5881 tctcttcctc aaaaagaaga aatcgcttta ggcggcgaag gtatgttcga agctaaattc
     5941 tacggtttgg gtgctgacgg tacagtaggt gctaacaaga actctgtaaa gattatcggt
     6001 gacaacactg acaaacactg ccaggcttac ttctcttatg actctaagaa gtcgggcggt
     6061 ttcacttgtt ctcacttgcg tttcggtgac aatccaatcc gttctactta tctggtaaat
     6121 actccgaact tcgttgcttg tcacgttcag gcttacctgc acatgtacga tgtaactcgt
     6181 ggtttgcgta agaacggttc tttcttgctg aacacaatct gggaaggtga agaactggct
     6241 aagaacctgc ctaacaaggt taagaaatat tttgcacaga acaacatttc tgtatactat
     6301 atcaacgcaa cacaaattgc actggaaatt ggtttgggta accgtaccaa cacaatcctt
     6361 caatctgcat tcttccgtat cacaggcgtt attcctgtag accaagctgt tgagcagatg
     6421 aagaaattca tcgttaagtc ttacggcaag aagggtgaag acgttgttaa caagaactat
     6481 gctgccgttg accgtggtgg tgaatacaag actttggctg ttgatcctgc ttgggctaac
     6541 cttccggatg acgcaaaagc tgaaaacaac gatcctgcat tcatcaacga agtagttcgt
     6601 ccgatcaatg cacaagacgg tgacttgttg ccggtatctg cattcaaggg tatcgaagac
     6661 ggtacttggt atcaaggtac tgctaaatac gaaaaacgtg gtgtagctgc attcgttcct
     6721 gaatggaatc cggaaaactg tatccagtgt aacaagtgtg catacgtttg ccctcacgct
     6781 tctatccgtc cgttcgtact cgacgctgaa gagcagaagg gtgctaagtt cgaacaactg
     6841 aaagctgtag gtaaagcatt cgacggtatg acattccgta tccaggtgga cgttctcgac
     6901 tgtctgggtt gcggtaactg tgctgacatc tgtccgggta atccgaagaa gggtggcaaa
     6961 gcattgacaa tgaaacacct cgaaagccaa ttggctcaag ctgaaaactg gacttactgt
     7021 gctgaaaacg tgaagactaa acaacatctt gttgatatca aggctaacgt gaagaactca
     7081 cagttcgcta ctccgttgtt tgagttctcc ggcgcttgct ctggttgtgg tgaaactccg
     7141 tacgtgaaat tgatttctca attgttcggt gaccgtgaaa tggttgctaa cgctaccgga
     7201 tgttcttcta tctactctgg ttctgttcct tctactccgt atactacaaa cgaaaacgga
     7261 cacggtcctg cttgggctaa ctcactgttc gaagacttct gtgaattcgg tttgggtatg
     7321 gaactggcta acgaaaagat gcgtgctcgt ctcgtgaaag tgatgaacga ggctattgct
     7381 gctgattgca ctcctgctga agtaaaagaa ctgttcgctg aatggatcaa caatatgctg
     7441 gatgcggaca agactaagga attggctgct aagatcattc cggttgttga agctaacaag
     7501 gataaatgta accactgcaa acaaatcgct gaactgcaac aatatcttgt aaaacgcagc
     7561 cagtggatca ttggtggtga cggtgcttct tacgatatcg gttacggtgg tcttgaccat
     7621 gtaatcgctt ccggtaagga cgttaacatc ctcgttctgg atactgaagt ttactctaac
     7681 acaggtggtc agtcttctaa agctactccg gtaggtgcta tcgctaagtt cgctgctgct
     7741 ggtaagcgcg tacgtaagaa agacctcggt ctgatggcta ctacttacgg ttatgtatat
     7801 gttgcacaga tcgctatggg tgctgaccaa gctcaaactc tgaaagctat ccgtgaagct
     7861 gaagcatatc cgggaccatc tttgattatc gcttatgctc catgtatcaa ccacggtctg
     7921 aaagcaggta tgggtaagag ccaagaagaa gaagaaaaag ctgttaagtg cggttactgg
     7981 cacttgtggc gttacaaccc ggctttggaa gaagaaggca agaacccatt ccaattggat
     8041 agcaaagaac cgaactggga agatttccaa ggtttcttga agggtgaagt tcgttacgct
     8101 tctgtaatga aacaatatcc tgctgaagct gaagaactgt tcaaagctgc tgaagaaaac
     8161 gctaaatggc gttacaacag ctacaaacgt ttggctagag aaaactgggg tgctgaataa
     8221 tagtaatacc ctataaatat aaaacggtaa tcttgtagaa gattaccgtt tttttattgt
     8281 atgaactctg tctaacataa acaatactcc ctttttccca ctagagttca tgtctatttt
     8341 atatttaaaa ttaaaaataa caatgctcca atctatttat tctctgactt cggaatccaa
     8401 ctatccacca actgccgatg ttcatccctc catttacggg ctatttcttc ttcatccatc
     8461 cgggcatcct tcatagctgt cataaaagag ctaagttctt ctgtcgttag tttgatgttg
     8521 ccaaagaatt cggcagcaaa cggatctttc tcactgaatc ctttccatgc aatagcatgt
     8581 atttcttcca agtctccata tactttcttc ggatcatcca agaatttcaa gtcaaactgg
     8641 tcgaacatcc aatgcggtgt ccaccccgtg atgacaatcc attctccttt gtccatcgct
     8701 tttttcaaag aagccagcat ggtggaacta cttgaagtca tgagggtata cccatcaagt
     8761 ccgtaagcag caatggcctt atcggtcgtc ttcataattc ctgctccggc atcaattccc
     8821 actatttcag aagagaaacg gtctttatta gcttccagct cactaataga ctggatcgta
     8881 acatattgag gaacaaccag tcctacacgg gcttctccat atacctcacc caaaaattcg
     8941 atgctgtctc catactgatc catataatct ttcatcgtta ttggtaacca ggcatccaga
     9001 aagacatcag atttctttcc tgacatagat acaaagatgg gggcaaggtc agcattttgc
     9061 agttcaacct catatccatg ttcttccaat accaccttag ccaaatgact catggcaata
     9121 ccttccagcc aattggcata ggctatcttt actttctttt tctctaaatc tgaattagta
     9181 caggaagcca gcaaaagtat agctgacaat actattccta ctattttata tattctcata
     9241 cgtattttat cctttccgtt tagttcttat tttttcgtcc tgccattcct tgtgtgatac
     9301 ggtctaagat gatagctaaa ataacaactg cgataccacc ttcaaaccca agtccgattt
     9361 tcatttgggt aatacctttc aatacaattt ctcccagacc accggcagca atcatggcag
     9421 caatgacaac catagaaagc gacatcatta ttgtctgatt gacacctgtc aggatggttg
     9481 gcaacgccaa aggaagctgc actttataca ataactgcca acgggtagcc ccgaacgaac
     9541 gggaagcttc cactacattt ttaggaactt gccgaattcc caatccagta aggcggacca
     9601 caggaggcat agcaaagata atggtggcaa acactcccgg cactgctccc aatccgaaaa
     9661 acaaaacggc aggaatcaga taaacaaaag caggcatcgt ctgcatcaag tcgagaacag
     9721 gacgaagtat tttctctgca cgcggactgt ttgccgtcca cactcctaaa ggtacaccaa
     9781 caatcagagc cagacaggta gatgaaaaaa cgagagccag ggtttgcata gtagcctccc
     9841 aaaatcccat tccataaatc agtaataatc ctaatgcggt gaaaattgcc gtaccacgtc
     9901 ctgccttcat ccatgcgagt gcagcaagca ctagaatggt tatataaaaa ggtattccaa
     9961 aaagtacgtg ttggaatcct ataataaaac taccgatgcc tgcattcacg gcatcaaaga
    10021 aagtggaaaa atgtaccatc atccaattga tggccatctc tatatattgt cctatattta
    10081 tcataaatct attgcgtttt gaattatttc gtttatttct tctttatctt tccccgtcac
    10141 ttcgatgatt aaggaggaaa gcgggattgt tcctaaaaac tcatgcgtct catcaatcac
    10201 ccataccggc gaattgctct ttgtcattaa aggaagtata tcctccaaca ctgtatcctc
    10261 caatacagaa tgtacttctg tacgcacaat cgtttcaatg gatttttcct gtctgctacg
    10321 taacttaagc aggtcgttca gacgtacttc tccgaccagt ttatcatcgg cgtctatgac
    10381 aggtaatacg gtgatattct tcgcacgcat cttacgaatc aatacttcag gtccctcttt
    10441 cttcagacgg gccaccagtg gtttgtcaat cattaaagaa gaagcggtga taattttact
    10501 cctgtccacg ttttcaacaa aacgggctac ataatcgtta gccggttcgg tcagtatttc
    10561 ttctgaagta cctacctgca ccacctctcc gtctttcata atggcaatac ggtcgcccag
    10621 tttaatcgct tcactcaagt catgggtaat aaagacaatt gtttttttca tcttcgactg
    10681 caaagccagc agttcatcct gcatttgcac acgaatcaga ggatcgagcg cagagaaagc
    10741 ctcatccatt aaaagcactt cgggattatt agccagagca cgggccagtc cgacacgctg
    10801 ttgcattcca ccggaaagct cgcccaccat ctgattttca tatcctttca atccgacaag
    10861 cttcatactt tccatcgctt tcttctcacg ttcctctttc ttcactccct gaagttcgag
    10921 accgaacgcg atattgctca atacggaacg gtgaggtaac agaccgaaat tctggaaaac
    10981 catcgccaac tctttccggc gaacttgcaa taactctttt tcggatattt tagatatatc
    11041 tactccgttt acaagcactt gtccggcagt aggacgtatc agacgattga tacaacgcag
    11101 taatgtcgat tttccacttc ccgagagtcc cattatcaca aaaaactctc cttcattaat
    11161 tgaaagattg gcatctttca ctcctaccgt acaaccggta tctttcagaa tttcctcttt
    11221 actcttatct tttttcaaca tcttgagtgc tttctgcttc tcgtgaccaa agataaggta
    11281 caaatccttt atttctattt tactcatata atatattggt ttagattata atagttgttt
    11341 tgttttcaac tgctgcgttc ctcattctca cttacgataa acaagttgaa tgttcgcatg
    11401 gttcagtcat gtcacatgac aacatgatga tccgacgttt tttaaaatgg ttttaaaaga
    11461 cagactgagt agtttaaaag gaatagaatt tgataagatt atcctctcaa tgaacagtag
    11521 aaaacagtat tttcataaat aaataacagt ctgttcttgc atattgttgg cacaaaggta
    11581 agggaaatag attaaatatg caaatttcat tcagatacgg agtaattcca aagatgcttt
    11641 ttcaagtcta cgcatccatt ttgcttgaaa gagatccctt cttccaacaa gagttgtttc
    11701 tgctctgtcc accccggaac aaggcgtccc gatgcattga caacccggtg acaaggcgta
    11761 gataaatcat ccggaacctg tttcaaggca cgccccacca tacgggaaca ttgaggcatt
    11821 cccaataatg cggcaattcc cccataggta gaaactttac ctaccggaat ttcccgaaca
    11881 acctgataca cctcctgaca aaaggatgtg gaaaggcttg ccttatctac tttataatct
    11941 ttcatcgcct ggactttatt tatttcattc ccaaagctag ataaaaagaa gagaatttgc
    12001 aaataacaaa agcatttcaa ataaaatatg caactttatt tgctttattt acaaataatc
    12061 ccgacctttg tacccattaa aagcaaccct attattaaca aaacaagcac tgctgttatg
    12121 aaaaagaaga caattctatt cgcttcttgt ttattgggag tattcgcttt cagctcctgt
    12181 gagaagaacc tttatgatga aagcaagcaa cctgaaaaag aaattcaagt aaaagacctg
    12241 gatatacccg caggctttca atggaaatta actcaagtag ccgcaggaac agtagctgct
    12301 actaccccca ctatggtttc cttctttttg gatgaagcat gtagtaaaga agagaaaata
    12361 gccgacattc ctgtagatac agaaatttca agtctccctt tgagcatccc aacctacgta
    12421 aatacattgt atgcccagta caaaaccagc accaatgaaa ccaaaaaagt agccatacct
    12481 gtaaatgcag atagaagttt ctcactgaac attgctaatg atgccaaatc caaatctaac
    12541 accacccggt caatcactcg tgggcatgat atagaagatg acatccaatt gtcaaaagga
    12601 gtcatttttc atcccaaaga tggttgggga acaatcatgt ttgaagacca atttccatca
    12661 ttaggagatt atgactttaa tgattttgta gtcaattata aggtgcagtt ccaaggtatt
    12721 agaaaggttg acaaaaaata cactgcgcag tatatacaaa tagggttacg tctaaaagct
    12781 atcggaggaa tattccctta ttccccttat ttaagactga aagaaataga ttctgacgaa
    12841 gtggaaagta tagaagttta tgaaactaaa aacgtgattc ctgcgatcga cggagtagaa
    12901 cttgtcccca ataaacatct tatcattgat tacagccctt taattaagaa tctggctaaa
    12961 cctgcaggca gccaatatta taatacagaa aagaatgctt tggtagcaac aagtgattta
    13021 ccggagatca atattctgat caccctaaag aagagaaaag aagtaaagga aatattagaa
    13081 ggcgatgaat tcgacttgta tttaaaacgt aatgatagcg gaacagaaat ccatatgaat
    13141 ggtattgaac cgatcactta ccaatatcca ttcaatgata aaaatctgct accgatatat
    13201 acaaacgggg acgaagaaga tgataattat tattttagtg caggacgcct gatttgggga
    13261 ttaagagtac caggcaacgc agcgcatgct attgaaaaag ctaatttctt ggaagcctat
    13321 aaaggatttg caaaatgggc gcaaagtagt ggcaaaaacg aacaaaactg gtataatcaa
    13381 ggaaacgcag ataaaagttt attgattcat aactaacaca tatcaataaa tcccggcaaa
    13441 cattgaaaat tcaagttacc gggatttatt gtattctaac gtgaatagtt ttgattctat
    13501 cctttcctct tcagcaaatc tgtcggactt tctccaaact gctctctata acatttggta
    13561 aaataagaag gagagctgaa accgacttca taaccaatct ctgccactgt catatccgac
    13621 gaagcaagca gggaagcagc tttctttaaa cgagcgatgc gaagcaattc attcggagaa
    13681 taattagtca aagattttat tttgcgatag agctgcacac gacttaatcc catatcctta
    13741 cccaaatctt ctacattcaa atttgagtct cccatctttg cttcaatcaa agtcttgaat
    13801 ttttccacaa agtctttatc catatcgcaa acatcctctt tcgccaacgt ttgtccgtca
    13861 ccaaagaact gtttcaggcg gcgatgtgaa tctatcagat tacgaacgcg tgccaacagc
    13921 aattgcgaac tgaagggctt ggagatataa gaatccgcac ctccgtcata tccctgaatc
    13981 cgttgttcat ccaaagaaca ggctgtcaat aagatgacag ggatatggca ggtttgcagt
    14041 tcgcttttca gacgacggca acactctatt ccatcaatac caggcatcat cacatcagag
    14101 attatcaagt ccggaacata tttcattgct ttgcggatgc cctccgaacc gtctgctgct
    14161 tcaattacag tataatcggt atggagtaat ccgcgtacat acgaacggat atctgcatta
    14221 tcatcaatta ccaaaacgga aggtttggaa gaatcatagc ctttttccag ttcctcttct
    14281 tcggcagcta aagttccatt caggtcggaa gaggcgggag atccgggaga agcaggattt
    14341 aaaggaactg cagagattga tgactttaga gaatcttcgg ccagaatagt ttcacaagtc
    14401 tgtaccggta aatcaacggt aaaaacagtg ccctgctttt catcactttc cacagaaatt
    14461 gtacctttat gcaattcaac gaaagctttg accaatgcaa gcccgattcc cgaaccggca
    14521 tggtgcatgt ctattttata aaaacgatcg aaaatgctcc gaatatgttc ggcggaaatc
    14581 attgaaccgg tattggcaac agtaaaacga atccagcgag tatcctcttt cgttaaggaa
    14641 gataaacgaa ccgttatctt tccattttcc ggtgtgaact tgaacgcgtt ggaaagcaga
    14701 ttaaaataaa tacgttccaa cttttccata tccgccaatg tatggtaatc cgtatccggc
    14761 atattatcaa aagagaaatg aatgtgtttc ttccgggccg ctgcaaggaa tgattcgttc
    14821 cagccctcaa aagaggaaag aacatctatc tgaacaggtg tatattccat cttaccgttc
    14881 tcgtatttac ggaaatccag aatctgattg acaagacgta agaggatatt cacgtttcgt
    14941 tgaatcagca tcaacattcg atgctgatct ccacttagtg tatgatcggc caataaatgt
    15001 tctaccggat cggcaaccaa tgtaagcgga gtacggaaat cgtgagatat atttgtgaag
    15061 aacaccagtt tggcatgcgt tgcctcttcc agttgatgag aaagctggat gagctgatcc
    15121 cgttgctctt ccagtttgtc ccgctgttct tctaattggt cacgttgttc ctctaacttg
    15181 tcccgttgct cttccagctg tttcttctgc tcggaaagtt ccttattcag acgattttta
    15241 gcacggagag atttatagac taccaataat aagcctgcca ccaatagaag aataaccaaa
    15301 ccgccataca tcaccacctg ctgtgtagca acccgagaca gatatccgcc gatacgtccg
    15361 ttcaatgttt caatcttctg atccagttcc gagatgtgag ttgtctgaag ttgcatgaca
    15421 tgcgcattcg tacggtcgac caccgcagtg ttcatgaccg tttcccgggg ataaggcttt
    15481 ttctcaagga tattcattgc cagttgcatc actttgtcgc cattggtcgg ataaataaaa
    15541 gtagcattca acacactgtc gagcaccatt tccaatccgt tacctttgcc ggggagagcg
    15601 tcgataccga caaaaatcat ttccttctcc cgtcccactt tctttgcagc ctgataagct
    15661 cccggagcga tacggtcatt atgcgcatac acggcgtcta tcttcggatg ccgacggagc
    15721 atactatcca tttccacttc cgccggttca cgctcccacg cagcatccgc tttatcaatc
    15781 agtttgatat ccggaaagtt actgatagca gccataaatc cttgatggcg ttccatggca
    15841 ggagttgagc cacccagtcc ggtaagttcc accacattcc cttttccttt caggctcgac
    15901 gcaatataat tgcctaccgc acgtcctatt tcataattgt cggcaccgat ataggcagta
    15961 tatttatcag aaagaatctt ccggtctacc aggatgacag gtattccctt ttgataagct
    16021 tcctctacaa tcggagtcat gggggccgct tcgttggcag agataatcaa taagtcaacc
    16081 ccttcatcta taaaataatg aacgtcttcc gcctgtttgc gattatcatc cgcagccgac
    16141 cggatttcaa ccgatacccc atcgtagaac attgcttcgc gaagaatttc atcattcatc
    16201 ttatgccgcc aggagtcatc actacattgc gccaccccga tacggaagcg gtgtgtgtcc
    16261 tgccgacaag ccgtcatgcc aagaagacag agcaagactg ctatccactt tgtatatccc
    16321 atcattctaa tcattctcat ttttttcgta tttctttcta tgacccaaat ggacgattga
    16381 gaacaaaaat aagaaataaa actgtgagta tgctatctat cacccaatta ttctcatcat
    16441 taccctccaa agaaatacaa aacagtttcc aatattcaac cggaaactat taacaaaagt
    16501 ataaagcgta agacaaacac tcaataaatg ttataaaaca tctcttttta tttggattat
    16561 ttgcagattt agcagaagtc cgtatctttg cggcaagaag ttacgaaaag agtgtaattt
    16621 attggaaatg agcgtaggtt aattgctctt gatagtaata ggttacgatt tagttagtta
    16681 tctactgcat tatccttctg cgcgttgcgt aaccttcaaa gaactcttcg tatgc
//
