LOCUS       c00045_gnlPro..        14900 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NDPGNIHK_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 10:51:22
            Original ID  :: gnl|Prokka|NDPGNIHK_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 75327
            Orig. end    :: 90227
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14900
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[85327:90185]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14858
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14900
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14900
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             619..1887
                     /locus_tag="ctg45_70"
                     /transl_table=11
                     /translation="MKVFKILFLLLITVLVPLNAQVTYFTNVSDKQIKTLQVKVAGEMF
                     SDPFIELGGENRIEVNFDAFNPGFGRYAYNLVHCNADWTQSNLSPIEYMNGFQGSTIED
                     FANAMGTTVQYTNYRLLFPNDDVQPKVSGNYALQVYNEDDPSQIVFTACFSIFEPMVSV
                     AATVSGNTDIDTNQSHQQVSFAINNKNFPITYPQTDLKIWVYQNNRRDNAVTGLQPMTI
                     LENQISYTNNQNLIFPAGNEYRRMEFLSNKYNGMHVESISFHNPYYHVELMTDYRRDQL
                     SYQYDQDQDGRFFIRCSNCNDPDTEADYYIVHFTLAMDLIPDGNVYLNGELYNNVLDEK
                     SKMGYNPETHQYEKSVLLKQGSYNYQYLFVPNGQTVGQTGPIEGNFFQTENEYSIYVYY
                     CPMGARYDRLIGVTSIRNTMPVL"
     CDS             1932..2900
                     /locus_tag="ctg45_71"
                     /transl_table=11
                     /translation="MKTRRIVISTVLLVGGLLSIVQVMPKNPLLIGERLFPYGGWIQVI
                     LAMLYGGWLCYKMQDRQERPKWRKRAWLLFSIVFFGQLALGIFADPIFLMTGKLHLPIP
                     AVILAGPLYRFEGLFMPILFISTLLLSGPAWCSQLCYFGAFDAWSARGKLERKRFPYHK
                     QMRYSILFLVMLGAILLRIFGASGRIATAFGIAVGVIGLLIMLLFSRKRRKMVHCSSYC
                     PIGTLVSFLKYLSPFRVRLTTDCCHCMACTNACRYDALHKEEIKKGKIGYTCTYCGDCL
                     SACKHGAIEYHFPGLRPTTAERLWIVVTVVLHTCFLMIARI"
     CDS             complement(2865..4205)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_72"
                     /sec_met_domain="Amidohydro_1 (E-value: 4.9e-69, bitscore:
                     225.6, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTMMKNLYRGEVLYLIASPLDHVEAYRYFEDGGLAVVDGKIVEAG
                     PFEAMRSRYPDFPVTDYSGKLITPGFIDSHIHFSQSEIQGMYGKQLLDWLDEYTFPAEE
                     AFSSMEYAQDIARFFVKELVKNGTTTCAAYATVHPASVTALFSVATEYNMCILAGKVMM
                     NRNAPDYLMDTTHQGELDCRSLIEDWDGKGRNHYVITPRFAITSTPDQLKSAGRLHAEY
                     PSTYIQTHLSENLGEIESVLSLCPGHADYLEVYERAGLLTDRSIFGHCVHLTDREYKRL
                     GETGGIIAHCPTSNLFLGSGLFDMREANRYGVRTTLATDVGAGTSFSMWRTMGEAYKVQ
                     QLNGYPMTALEAIYKCTLGSARALSLDDRIGSFLPGREADFIVVDYAATSVQKLRMEYL
                     RSRDKWTIENKLFGLQTLGDDRNTVCTYIMGKQVYGSDSCDHQEASM"
     CDS             complement(4218..5084)
                     /locus_tag="ctg45_73"
                     /transl_table=11
                     /translation="MRVTLLGSFANFVLLVFKFVAGIWGHSSAMIADAVHSLSDFVTDI
                     IVLLFVNISSKPKDESHDYGHGKYETLATSIVGIVLLCVGFGLFWEGANKIYDFYFKGI
                     PLESPGMIALVAALISIVIKELLYHITVWVGRKQNSQVVIANAWHHRSDAFSSIGTALG
                     IGGAILLGDNWRVLDPLAAVIVSLFIVKVALQLVIPAINDLLEKSLPKEVEDEILAIIS
                     EIPEVKSPHNLRTRRIGNNFAIEAHIRVDGQITVTRAHDLTKEIEQNLRDKFGQATHIA
                     LHVEPIK"
     CDS             complement(5130..6422)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_74"
                     /sec_met_domain="SDH_alpha (E-value: 1.4e-59, bitscore:
                     194.2, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTIIKTQIIDLIHREVIPAIGCTEPIAVALAAAKAAEVLGRKPE
                     KIEVYLSANILKNAMGVGIPGTGMVGLPIAIALGSIIGKSAYGLEVLKDLTPEGLKEGK
                     EMVCKKCIGIDLKENVDKLYIEIISSAGNDRSRVIICYEHTHIIYVEKNGEVLTDLRMA
                     NASGEEVCENKDLRLSFSMVYEFAMEMPLDEIRFILETAELNKKAAQASMKGNYGHTVS
                     KTVSGAFGRKFMGDSAYTHMLIMTSAACDARMDGAMIPVMSNSGSGNQGIAATLPVLSF
                     AEDIQCSEEQLIRALMLSHLMVIYIKQSLGRLSALCGCVVAATGASCAITYLMGGNKVR
                     ISYAIKNMIGNITGMICDGAKPSCAMKVSSGVSTAMLSALMAMEDKVVTSVEGIIDEDV
                     DKSIANLTAIGSKGMEATDRLVLDIMTGKSC"
     CDS             complement(6467..6838)
                     /locus_tag="ctg45_75"
                     /transl_table=11
                     /translation="MNENDAFYNALIDVAAWDKENTLDRFMNSDSLFKKFLYKFITTDG
                     SYVKLRSSLVERDLENAKLYSHTLKGIAANLGLVNLFDVSNNILSLLREGNLEEALRYE
                     DALGKQYDALRDIVVEFCS"
     CDS             7024..8946
                     /locus_tag="ctg45_76"
                     /transl_table=11
                     /translation="MGISSPLVDLQHQYDLLQKEYEYEKETYRQQSERTGLRKRVAQGL
                     CWYPVTPGRSYYNSLNQLVIEIERTENREIEHNFEYGRPVCFFTADISGKFKYLDFSAT
                     ISYVQEDRMVVVLPTPSALMDIQGKSNDLGVQLYFDETSYKTMFSALSDVMRAKNNQLS
                     HLRDVLLGQEKPGQRELFPIRFPWLNRSQEEAVNKVLGAKQVSIVHGPPGTGKTTTLVE
                     AIYETLHRENQVIVCAQSNTAVDCISEKLVDRGINVLRIGNPTRINDKMLSFTYERRFE
                     SHPDYPELWSIRKAIRDIQSNMRKKSREERDTIRNRLSRLKFRATELEVKIDTELFDEA
                     RVVACTLVGSANRVMMNRHFTTLFIDEAAQALEAACWIAIGKADRVILAGDHHQLPPTI
                     KCIEAEREGLGRTLMQKIAHTKPETVSLLKIQYRMHEDIMRFSSQWFYHNELESAPEVS
                     GRGILRLDTPIVWFDTSECDFTENTREETMSRVNRQEAELLVEQLRSYIQKISKERVLE
                     ENIDFGLISPYKAQVQYIRKLIKQDAFFKPLRRLITVHTVDGFQGQERDVILISLVRAN
                     EDGKIGFLNDLRRMNVAITRARMKLMILGDASTLTRHAFYKELYNYISQRGKIITINTK
                     QEHEL"
     CDS             8951..9742
                     /locus_tag="ctg45_77"
                     /transl_table=11
                     /translation="LVLDLDGTLTNSKKEITPFTRETLLQAQEKGLHLVLASGRPTYGI
                     VPLAEELNIKQYGGFILSFNGGKVIDLMTDKVLFEQALPPDIVPVLYNRSKEAGLAILS
                     YNGKYILSEHPENKYVQYESFLTKMKIKATDDFLRDLHQPADKCLVVGEPEMLVPLEEK
                     LRQELGKRINVYRSEAFYLELVPKGIDKAASLSRLLERTRIKQEEVIAIGDGFNDVSMI
                     HFAGLGVAMANAQPPVKANADRITQYTNDEDGVARFIQELL"
     CDS             10001..11233
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_78"
                     /sec_met_domain="HBT (E-value: 1.1e-16, bitscore: 53.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDKKEITPRTHAALLKAQQMGVHVVLASGR
                     PTNGVQPLAEALELNHYGGFILSYNGGQIINAQTGELMFEKRIDPAMIPYLNRKAKENG
                     FAIFTYHKDYILTDSPENKHVQEEAELNKMRIIGVENFPEAVDFAPCKCILTSDDENNL
                     VGLENHWKKRLDGVLEAFRSEDYFLEVAPHFINKGNTLAVLMEMLNITTEEVVAIGDGV
                     ADVSMLQLAGTGVAMGNARDSVKACADFTTLSNNMDGVAVAIEKAILATIKPTEVPLDQ
                     LNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDIFTSTDKLVSS
                     VRVINSILKKK"
     CDS             11230..12327
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_79"
                     /sec_met_domain="Chorismate_bind (E-value: 9.3e-54,
                     bitscore: 175.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRDSYEIIDTLIKQGRSFAIWRIPGEDRLHFRMQSAGSPCLLY
                     DIKDLNERSGFVIAPFQVTAERPIVLIQPDCFEIPSESDWDFSREKNEFPSNEIEIPSE
                     SEEKERYAYHFSLFTSPLLKGSQDKLVLSRSKTIRKDPSFSPGKAFFAAVERYIRSYVY
                     LCHTPETGTWMGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQLVAS
                     YIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPAVCGL
                     PKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGGGLLA
                     ASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             12342..14030
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_80"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.8e-07, bitscore:
                     21.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLIEHGVSNIVLCPGSRNSPIVHTLANHSFFN
                     CHSVTDERSAGFFAVGLALHGGKPAAVCCTSGTALLNIHPAVAEAFYQKVPLVVISADR
                     PAAWIGQMDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLELNHHGKGP
                     VHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRMMIAGQMS
                     LIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKLVPELVIT
                     YGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDAFEFLEKIAYMLEN
                     RQIEYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRYAQLYTVP
                     ETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGNLHNNLRI
                     LLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNAEELAAAM
                     SAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             14034..14858
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_81"
                     /sec_met_domain="ECH_1 (E-value: 2.1e-81, bitscore: 265.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
ORIGIN
        1 tggagccaac ggagcggagt aaaaagccga aacgaagata tcacgcggag tatccaatgg
       61 agcggcaacg atatcgtatg ggcgttgctt gataaacggc cacataccag cgttcagaag
      121 tacctctttc acctctgctc cctgtaggga tgctacgttc ttcttaccga actcctcata
      181 ctcgatctgc gcatccggct tcacaacgat gcttagcacc ttacgcttct ctcctcggtt
      241 tacggcagtt acctcgccac tgaccggcga aacaaacttg atctcggggc ggttcttgtc
      301 aatcatcagt acagaaccgg ctttgacttt ttctcctact ttcgcaacaa ctttggggag
      361 aataccgtta taataatcgg ggacgattgc gtaagactcg ctcttgccgc cgtttaacag
      421 tacatccgaa gctttgccct tcagattaat gtctaaaccc tttttaatct taatcacatt
      481 tgccatgata caactaaaat tgtttatatg taattttcct gcaaaagtaa acattttttc
      541 atgctttaga gcagggaaag gcaaataaat agagaaataa ttccataatt ttgcgtcgtt
      601 aaagaaagta ataagaaaat gaaagttttt aaaatcctat ttctgctgct tatcacggtt
      661 ttagtaccgt tgaacgctca agtgacttac ttcaccaacg ttagcgataa gcaaataaag
      721 accctccaag tgaaggttgc cggcgagatg ttctccgatc cattcattga actgggcggt
      781 gaaaaccgta tcgaagttaa tttcgatgct tttaatccgg gcttcgggcg atacgcctat
      841 aatctggttc attgcaacgc cgattggacg caatcgaatc tttccccgat tgagtatatg
      901 aatggtttcc aagggagcac gatcgaggat ttcgccaatg cgatgggtac tacggtgcaa
      961 tacaccaact accgattact tttcccaaac gatgacgttc aaccgaaggt ctcggggaat
     1021 tatgccttgc aagtatataa cgaggatgat ccctcccaga tcgtatttac cgcatgcttt
     1081 tctattttcg agccgatggt tagtgtcgcc gctacggtga gcggaaatac ggatatcgat
     1141 accaatcagt cacaccaaca agtcagcttt gcgatcaata acaagaattt ccccatcacc
     1201 tatcctcaga ccgacttgaa aatctgggtt tatcagaata accgcaggga taatgccgta
     1261 acaggtcttc agcctatgac tattttagaa aaccagatct cttatacgaa caatcagaac
     1321 ttgatctttc ccgcaggaaa cgaatatcgc cgtatggaat ttttgagcaa caaatacaat
     1381 ggcatgcacg tagaaagtat ctcgttccat aatccatatt accatgtaga gttgatgacg
     1441 gactatcggc gtgaccaatt atcgtatcaa tacgatcaag accaagacgg ccgttttttc
     1501 atccgttgca gtaattgtaa cgacccggat acggaagcgg actattacat cgttcacttt
     1561 accctcgcca tggacttaat tcccgatgga aacgtgtatt tgaacggtga attatataat
     1621 aatgtattgg acgagaaaag taagatgggc tataatccgg agacgcatca atacgagaaa
     1681 tccgtcttac tgaaacaagg cagttacaac tatcagtacc tctttgtccc taacggacag
     1741 accgtaggac agaccggccc tatcgagggt aatttcttcc agacggagaa cgaatatagc
     1801 atttacgtct actattgtcc aatgggagca cggtatgatc gtttaatcgg tgtaactagt
     1861 atcagaaata caatgcccgt gctataatta ttcgcgtaaa aggcatactt ttacgcataa
     1921 aataattgag catgaaaacg agacgtattg ttatcagtac cgtattatta gtcgggggac
     1981 ttctctcgat cgttcaagtc atgcctaaaa atccactgtt gataggcgaa aggttatttc
     2041 cgtatggagg atggatacaa gtgatacttg ccatgctata cggtggttgg ctctgctata
     2101 agatgcaaga tcggcaagaa cgtcccaaat ggagaaaacg agcgtggttg ttattctcga
     2161 tcgttttttt cgggcaactt gctctaggga tttttgccga tcctattttc cttatgaccg
     2221 gaaaattgca tttaccgatc cctgcggtaa tcttggccgg accgctttat cgcttcgagg
     2281 gattattcat gcccatactt tttatcagca ccttattact atccggtccc gcttggtgta
     2341 gccagctttg ttacttcggg gcattcgacg catggagtgc ccggggaaaa ttggaacgaa
     2401 aaaggttccc ctatcacaag caaatgcgat acagcatatt atttctggtt atgttggggg
     2461 ccatcctact ccgaatattc ggagcgagcg gcaggatagc caccgctttt ggaatagcgg
     2521 tcggagttat cggcctactt atcatgctat tgttttccag aaagagacgg aagatggtgc
     2581 attgcagtag ttattgtccg atcgggactt tagtgtcttt cctcaaatac ctctctcctt
     2641 tccgggtacg actgaccacg gattgttgcc attgcatggc ttgcacaaac gcttgccgtt
     2701 acgatgccct acataaagaa gagatcaaga agggaaagat cggctatacc tgtacctatt
     2761 gcggagattg cctctccgct tgcaagcacg gggctataga atatcatttc ccgggattgc
     2821 gcccgactac tgccgagcgc ctatggatcg tcgtaacggt cgtattacat acttgcttct
     2881 tgatgatcgc acgaatctga gccgtatact tgcttgccca ttatataagt acataccgta
     2941 ttccggtcat cgccgagggt ttgcaggcca aacagcttat tctcaatcgt ccatttatct
     3001 ctcgaacgaa gatactccat acgcaatttc tggacagagg tagcggcata atccacgact
     3061 atgaaatccg cttcacggcc agggaggaaa cttccgattc ggtcgtccaa cgataaggcc
     3121 cgtgcagagc ctagcgtaca tttatagata gcctccaaag ctgtcatcgg ataaccgttc
     3181 aactgttgta ccttataggc ctctcccatc gtacgccaca tagagaaaga tgtacccgca
     3241 ccgacatctg tcgccaaggt agtacgtacg ccgtaacggt tcgcttccct catatcgaat
     3301 aatccgcttc caaggaaaag gttcgaggtc gggcaatggg cgataatgcc tcccgtttct
     3361 cccaaccgct tatattcccg atcggttaga tggacacaat gcccgaatat cgaacgatcg
     3421 gtcaacaatc cggcacgctc atagacctcc agataatccg catgaccggg acagagcgat
     3481 aagacagatt caatctctcc cagattctcc gaaagatgtg tctgtatata ggtactggga
     3541 tattcggcat gtaaacgacc ggcagacttt aattgatccg gcgtactggt tatggcgaaa
     3601 cggggcgtga tcacatagtg attccgtcct ttcccatccc aatcctcgat taagctacgg
     3661 cagtccaact caccctgatg cgtggtatcc atcagataat ccggagcgtt ccggttcatc
     3721 atcacctttc cagccaagat acacatatta tactccgtag ccacggaaaa taatgcggtt
     3781 acggaagcag gatgaaccgt ggcataagcg gcacaagtcg tagttccgtt cttcaccagt
     3841 tccttcacaa aaaagcgagc gatatcttgt gcatattcca tggaagagaa agcttcctcg
     3901 gcgggaaacg tatattcgtc cagccaatcc agaagttgct tgccatacat tccctgtatc
     3961 tccgactggg agaaatggat atgggaatca ataaagccgg gtgtaatcaa tttaccggaa
     4021 tagtctgtca ccgggaaatc cgggtaacgg gaacgcatcg cctcgaacgg ccccgcctct
     4081 acaatctttc catcaacaac agccagtccc ccatcctcaa aatagcggta agcctccaca
     4141 tgatccagcg gggaagcgat caaatagagc acttctcccc tatataagtt cttcatcatg
     4201 gtcaaataac aattcgttta tttaattggt tccacgtgca aagcgatgtg cgtagcctga
     4261 ccgaacttat cacgcagatt ctgttcgatc tctttcgtca agtcatgggc acgagtcacg
     4321 gttatctgtc cgtccacccg tatatgcgcc tcgatagcaa aattattacc gatgcggcgg
     4381 gtacgtagat tatgcgggct ctttacctca ggaatctcac taatgatcgc caagatctca
     4441 tcctccacct ccttcggcaa agatttctcc aataagtcat taatcgccgg gatcactagt
     4501 tgtaaggcta cttttacgat aaataaactg acaatcacag ccgccaacgg gtccagcaca
     4561 cgccaattat cccccaacaa aatcgcccct ccgataccta aagccgtacc gatcgaggaa
     4621 aaggcatccg agcgatgatg ccaagcgtta gcgataacga cttgactatt ctgcttcctt
     4681 cctacccaaa ccgtaatatg atacagtaat tccttgatca caatggagat aagagcggca
     4741 actaaagcga tcattcccgg actttccaac ggaatcccct tgaaataaaa gtcataaatc
     4801 ttgttcgctc cctcccagaa aaggccaaaa cctacacaaa gcaagacgat accgacaatt
     4861 gaagtcgcca aagtctcgta tttaccatgc ccgtaatcat ggctctcgtc ctttggcttg
     4921 gaagatatat tgacaaaaag aagtacgatt atatccgtta cgaaatcaga taacgaatgt
     4981 accgcatcgg cgatcatagc gctactatgc ccccagatac ccgccacgaa cttgaatacc
     5041 aataaaacaa aattagcgaa tgaccctaaa agtgtcactc gcataatctc ttttttcctc
     5101 gcctttggtg cctcctccat agaatcccat taacaagatt taccggtcat gatgtccagc
     5161 accagacgat ccgtcgcctc cattccttta gaaccgatag cggtcaagtt cgcgatcgat
     5221 ttatccacat cctcatcgat gataccttcc acggaagtca ccaccttatc ctccatggcc
     5281 atcaaagcgg aaagcatcgc cgtagatacg ccactagata ctttcatcgc gcaactcggc
     5341 ttggcaccgt cacagatcat tccggtaata ttaccgatca tattcttgat cgcataagaa
     5401 atccgcacct tatttcctcc catcaaatag gtgatagcgc aactcgctcc cgtagcggca
     5461 accacacaac cgcaaagggc ggacaaacgt cccagacttt gcttgatata gatcaccatc
     5521 aaatggctta acatcaacgc acggatcagt tgctcttccg agcattggat atcctcggcg
     5581 aaagaaagaa ccggaagcgt agcggcgatt ccttgatttc cgcttcccga attactcatc
     5641 accgggatca tagcgccgtc catgcgagcg tcacaagcgg cggaagtcat gatcaacata
     5701 tgcgtataag cggaatctcc catgaactta cggccgaaag cacccgagac cgtcttgctt
     5761 acagtatgtc cgtaattgcc tttcatggaa gcttgggcgg ctttcttatt caactcagct
     5821 gtttctaaaa taaaacgaat ctcatccaat ggcatttcca tggcaaactc atagaccata
     5881 gagaaggaaa gacgtaaatc cttattctca catacttcct cgccagaagc gtttgccata
     5941 cgtaaatcag tcaatacctc cccgtttttc tctacatata ttatatgggt atgctcatag
     6001 caaatgatca cccttgaacg atcgttccct gctgaactta taatttcgat ataaagttta
     6061 tctacattct ctttcaggtc tataccgata catttcttgc agaccatttc cttaccttct
     6121 ttcaatccct ccggagtcaa gtctttcagc acctctagcc cataagcgga cttaccgatg
     6181 atcgatccca aggcgatagc gataggcaac cccaccatgc cagtccccgg gattcctact
     6241 cccatggcat tcttcaggat attggcgctc agataaacct ctatcttctc tggcttacgc
     6301 cccagcactt ccgccgcttt tgcggccgcc aaagccacgg caataggttc cgtacatccg
     6361 atagcaggga ttacctccct gtgaatcaaa tctataattt gagtttttat gatagtatcc
     6421 atactgatag tctttattta gaattagata gttaatatac aatagattaa gaacaaaact
     6481 caacaacgat atctcgcaag gcatcgtatt gttttcccaa tgcatcttca taacgcaacg
     6541 cttcttccag attcccttct cttaacagcg atagtatatt attcgataca tcgaatagat
     6601 ttaccagacc taaattagcg gctatccctt tcaaggtatg cgaatatagc ttggcattct
     6661 ccaaatcccg ctctactaaa gagctccgta atttcacata cgaaccgtct gtagtaataa
     6721 atttatatag aaactttttg aagaggctat cactattcat aaaacgatct aaggtattct
     6781 ctttatccca agcagctaca tctattaatg cgttataaaa agcatcgttc tcattcattt
     6841 ttttatgata ttagttttcg tacaaaatta ggaattttat agacactacc aacgttagcg
     6901 gtattctttt tctttactta ccgcaacttg ggtacggaac gataatttta gtacttttgt
     6961 cgcctacttc gggacctaga acgcccgggc tgtatttatc cgattaattg aattgataaa
     7021 ggaatgggaa tttcatcgcc gcttgtagat ttgcaacatc aatatgatct cctgcagaaa
     7081 gaatatgaat atgagaagga aacataccga cagcaatccg agcgtacggg tttgcgaaaa
     7141 cgagtggcgc agggcctctg ttggtatccg gtcactccgg gacgcagtta ttataactcc
     7201 ttaaaccaat tggtgatcga gatcgaaaga acagaaaacc gggagatcga gcataatttt
     7261 gagtacgggc gcccggtttg cttctttacg gcagatatca gtggtaaatt taagtatctg
     7321 gatttctccg ccacgatcag ctacgtgcaa gaggaccgga tggtggtagt tctccccact
     7381 ccttccgcct tgatggatat acaaggaaaa agcaatgatc tcggcgtgca actctacttc
     7441 gacgagacca gctataaaac gatgttttcc gctctctcgg acgtgatgcg ggcaaaaaac
     7501 aaccaactct ctcatctaag ggacgtattg ctgggacagg aaaaaccggg acagcgggaa
     7561 ttattcccga tccgcttccc ttggttgaac cgttctcagg aagaagccgt aaataaggta
     7621 ttgggagcga aacaagtatc tatcgtacac ggccctcccg gaactgggaa aacaaccacc
     7681 ttggtggaag ccatttacga gacccttcac cgggagaatc aagtgatcgt ttgcgcccaa
     7741 agtaataccg ccgtagactg catctcggag aaactggtag atagaggcat taacgtcctg
     7801 cgcatcggga accccactcg tatcaatgac aagatgctct ctttcacata tgaacgccgt
     7861 ttcgaatcgc atccggatta tcccgaatta tggagcatcc ggaaagcgat acgggatata
     7921 caatccaata tgcgaaagaa aagccgggag gaacgggata cgatccgaaa ccgcctctcc
     7981 cgtttgaaat tccgggcgac cgaactggaa gtcaagatcg atacagagct gttcgacgag
     8041 gctcgtgtcg ttgcttgcac cttggttggc tccgcaaacc gggtcatgat gaaccggcac
     8101 ttcacgacct tgtttatcga tgaggccgcc caagccttgg aagctgcttg ctggatagcg
     8161 atcggcaagg cggaccgggt catactagcg ggcgatcatc accaattgcc ccctactatt
     8221 aaatgtatag aagcggaacg agaaggctta ggacgtacct tgatgcaaaa gatagcccac
     8281 acgaaaccgg aaacagtctc tctcctgaag atccaatatc gtatgcacga ggatatcatg
     8341 cgcttctcct cccaatggtt ctatcataac gaactcgaat ccgctcccga ggtaagtggg
     8401 cgaggaatct tgcgactgga cactcccatc gtatggttcg atacgtccga gtgcgatttc
     8461 acggaaaata cgagagagga gaccatgagc cgtgtcaaca ggcaagaggc ggaattgctc
     8521 gtggaacaat tacgctccta tatacagaaa atatccaagg agagagtgct ggaggagaat
     8581 atcgacttcg gattgatctc cccttataag gcgcaggtac aatacatccg taaattaatc
     8641 aaacaggacg ctttcttcaa gcctttacgc agactgatta ccgtacatac cgtagacggt
     8701 ttccaagggc aagaacgcga tgtcatcttg atcagtttgg taagggccaa cgaggatgga
     8761 aagataggct tcttgaacga cttgcggcgc atgaacgtag cgatcacccg tgcccgtatg
     8821 aaactgatga tcttgggaga cgcttccacc cttacccggc acgcatttta taaagaactc
     8881 tataattata tctcccaaag aggtaaaata atcacgatca acacgaaaca agagcatgaa
     8941 ctataaatta ttggtactgg atttagacgg tacactgaca aacagtaaaa aagagatcac
     9001 cccgtttacg agggaaaccc ttctgcaagc gcaggaaaaa ggattgcatc tggtcttagc
     9061 ctccggccgg cccacctacg gtatcgtgcc tttagccgag gaactgaaca taaagcaata
     9121 tggtggtttt atcctttcct tcaacggcgg taaggtgatc gacttgatga cagacaaagt
     9181 acttttcgaa caggctttgc cacccgatat cgtacctgtt ttatacaacc gctccaaaga
     9241 agcgggactg gctatccttt cctacaacgg taaatatatc ttaagcgagc acccggaaaa
     9301 taaatacgta caatacgaat cattcctaac aaagatgaag atcaaggcta ccgacgattt
     9361 cctgcgggat ttacatcaac ctgccgataa atgcttggtg gtaggcgaac cggagatgtt
     9421 ggtaccgttg gaagagaagc tccgccaaga attagggaaa cgtatcaacg tatatcgttc
     9481 cgaggcattc tatctggagc ttgtccccaa aggtatcgac aaagccgcct cattatcccg
     9541 cttactagag cgaacccgga taaaacagga ggaagtgatc gctatcggcg atggtttcaa
     9601 cgatgtatcc atgatccatt tcgccggatt gggagtcgct atggccaacg cccagccccc
     9661 tgtcaaggcc aatgccgacc gcatcaccca atacacgaac gatgaggatg gagtggctcg
     9721 tttcatccaa gaattgcttt gaaaaaaaca cgtacgtatt ttccgagaaa cacgtacatg
     9781 ttttcgcgag aacacgtacg tgttttttca gagacattta caccagtatc gacacaggcc
     9841 aatgcctata tcggcataag cctgtacgta tatcgccgca aggctacacc gatataggcg
     9901 tgagcttgcg ccgatatacg taaattcctt tcatggaaat gtcttctaac tatcaactat
     9961 tttatgtaca tttgtattct aaaccataaa ataagacgcc atgaagtaca aattattagt
    10021 cttagacgta gatgggacgt tgcttaacga caagaaagag ataactcccc ggacccatgc
    10081 cgccctgtta aaggctcagc agatgggagt tcatgttgta ttggcatccg gccgacccac
    10141 caacggggtt caacccttgg cggaggctct tgaattgaat cattacggtg gtttcatatt
    10201 atcttataac ggaggtcaga tcatcaatgc ccagaccgga gaattgatgt tcgagaaacg
    10261 aatcgatccg gccatgattc cttatttgaa ccggaaggcg aaggaaaacg gttttgctat
    10321 cttcacgtat cacaaggact atatcctgac cgatagcccg gaaaacaagc atgtccaaga
    10381 ggaggccgaa ctcaataaga tgcgcatcat cggtgtggag aatttcccgg aagcggtgga
    10441 tttcgcaccc tgtaagtgta ttcttaccag cgatgacgag aacaatctag tgggtctcga
    10501 aaatcattgg aagaaacgtc tggacggggt attggaagct ttccgctccg aggactattt
    10561 cttggaggta gctcctcatt tcatcaataa gggaaatacg ttggcggtat tgatggagat
    10621 gctgaatatc acgaccgaag aggttgtcgc tattggtgat ggcgtagccg acgtatccat
    10681 gcttcaatta gccggtaccg gcgtggcgat gggtaacgca cgcgactccg taaaggcttg
    10741 cgccgatttc acgaccttat ctaataatat ggatggtgtg gcggtagcga tcgagaaagc
    10801 gatccttgcc acgatcaaac ccacggaggt tccgttagat caactaaacg cacgggccaa
    10861 acatgcctta atgggtaatc taggcattca atatacctat gcgtcggagg atcgtgtgga
    10921 agcgaccatg cctgtagacg aacggacccg ccagcctttc ggtatcttgc acggaggcgc
    10981 tacgctggct ttggcggaga ccgtggccgg actaggttcc atgattctgg cgaaaccgga
    11041 cgagatggta gtcggcatgc aagttagcgg cagccatatg tcgtccgccc acgagggaga
    11101 cacggtacgt gccgtcggga cgattatcca caaaggccgt tcatcccatg tgtggaacgt
    11161 agacatattc acctctaccg acaaactggt ttcctcggta cgggtaatca atagcatact
    11221 aaagaagaaa tgattccaag agattcttac gaaataatag acacgttgat caagcaaggc
    11281 cggagtttcg ctatttggcg tattcccggt gaggataggc tccatttcag gatgcaaagc
    11341 gccggctctc cttgcctatt atacgacata aaagacttaa atgaacggag cggttttgta
    11401 atcgctccgt ttcaggtgac agcggaacga cctatcgttt taatccaacc ggattgcttt
    11461 gaaatcccct ccgaatccga ttgggatttc tctcgagaga aaaacgaatt cccttcgaat
    11521 gaaatcgaaa tcccatccga atccgaggag aaggaacgat acgcttacca tttctccctg
    11581 tttaccagcc ctttgctaaa aggaagccaa gataaactag tcctatcccg tagcaaaacg
    11641 atccggaaag atccctcttt ctcacccggc aaggcattct tcgccgcagt agaacgatat
    11701 atccgctcct atgtctacct ttgccatacc ccggaaaccg gaacttggat gggtgggaca
    11761 ccggaaatct tgttatccgg cgagaaaggc gactggcaaa cggtagcttt ggccggaacc
    11821 caatccttac gagacgggaa attaccgaaa agctgggacc ataagaattg gagagaacag
    11881 caattagtcg cctcctatat acgccgccag ctgtccacct tgggtattac tcccgaggag
    11941 aaggggcctt attcagcccg ggccggagag gtttcccatt tgaaaagcga tttcttcttc
    12001 tccttgccga atcccgagaa gctgggtgat gtccttcaac tattacaccc tactccagcc
    12061 gtttgcggtc ttcccaagga ggaggcttat catttcatca tcgagaatga ggggtacgat
    12121 cgtagctatt actccggttt catcggttgg ctggatccca aaggcaaaac agatctgtac
    12181 gtaaacctcc gttgcatgaa tatcctcccc caaaccttta cgctgtatgc cggaggcggt
    12241 ctgttggcgg cctcgcagct agaggatgag tggcaggaga cagaggataa attagatacg
    12301 atgcggagaa tagtgggtaa tttataattt tatatcatat aatgtatagc gataaaaaga
    12361 acatccttca attggtagcc ttgctgatag agcacggcgt aagtaatatc gtgctatgtc
    12421 cggggagccg gaactctccg attgtgcaca cattggcaaa ccattcgttc ttcaattgcc
    12481 attccgtgac ggatgagcga agcgcgggat tctttgccgt agggctagcg ttgcacggag
    12541 gtaagccggc ggctgtttgc tgtacctcgg gcacggcctt gctgaatata catccggcgg
    12601 tagcggaggc tttctatcag aaagttccgc ttgtcgtgat atccgccgac cgccccgccg
    12661 catggatcgg gcaaatggac ggacagacct tgccgcaacc cggggtgttc ggctcgctgg
    12721 tgaagaaatc ggtacagcta ccggaaatac atacggatca agatgaatgg tattgtaatc
    12781 gattgatcaa cgaggctttg ttggaactga accatcacgg caaagggccg gttcatatca
    12841 acgtcccgat ctccgagcct ttatttcagt tcacgacacc cgaattgccg aaggtacggg
    12901 taatcacccg ttatcaaggc ctaaacgtgt acgaccggaa atatgacgat ctgatcgagc
    12961 gtttgaacaa atatagcaag cgaatgatga tagcgggaca aatgagtttg atctatctct
    13021 tcgagaagaa aatatgtaag ttactataca aacatttcac ttggctctcc gagcacatcg
    13081 gcaaccgtat cgtaccggga ttgccgatca agaatttcga cgccatcctg tacgctaccc
    13141 cagaggagga aaaagagaag ctggttcccg agctcgtgat cacctacggc ggccatattg
    13201 tctccaagcg gctgaaagag tttttgcgga aacacccgcc taaggagcat tggcatgtct
    13261 cattggatgg ggaggtagcg gatttattcg gtagcctgac cacggtgatc gagatggacg
    13321 ctttcgagtt tctggagaaa atcgcttata tgctggagaa taggcagatt gaatatccga
    13381 aggcttggga atataaatcc cggaatctgc cggagccgga gttcgcttac tccgaaatgg
    13441 cggcgatcgg tggtttgata cgttcgcttc cggctgaatc ggccttgcat ctggggaata
    13501 gctccaccgt acgttacgca caattgtaca ccgtacccga gacggttgag gtttgttgta
    13561 accgaggtac gagcgggatc gaaggctcct tgtctacggc tatcggatac gcctcggcct
    13621 cgcaaaaact aaactttatc gttataggcg atcttagttt cttctatgat atgaatgcgt
    13681 tgtggaacgg aaacttgcac aataaccttc gtatcctgct cttgaacaac ggaggtggtg
    13741 agatcttcca agccttgcca ggattcaaga tgaacgagcg tacgcaccgt tacgtcaccg
    13801 cctcccacca gacctcagcg gagggatggg ccacggaaag gggattctcc tactccgccg
    13861 ttcataacgc cgaggagttg gcagctgcga tgagcgcctt tacccaaacg gagcaaccga
    13921 gcgaacatcc cctattcatg gaggttttca cggacaaagc ggaagacgta cgattgctca
    13981 aggaatatta tcatcaacta aaaaattcat cccaagcaca aaacatataa tatatggaaa
    14041 cgaaaagaga atggacaacc atcaaggaat acgaggagat cttatttgat ttctacaacg
    14101 gcatcgcccg cattacgata aaccgggaac ggtatcgcaa cgcttttacc ccgactacga
    14161 ccacggagat gagcgacgcc ttttacatct gccgggaacg tccggacatt aacgtagtcg
    14221 ttctgacagg agccggagat acggcgtttt gcgcgggagg cgatatgaac gtgaaaggac
    14281 gtggcggcta cgtgggtaaa gacggcgtac ctcgcttgaa cgtattggac gtacaaaagc
    14341 agatccgctc tctcccgaaa cccgtcatcg cagccgtgaa cggtttcgct atcggcggcg
    14401 gacacgtatt gcacgtggtt tgtgacctta cgatcgcttc cgagaacgct atcttcggac
    14461 agacaggccc tcgtgtgggt agcttcgacg ccgggttcgg ctcttcttac ctcgcccgtg
    14521 tggtcggaca aaaaaaggcc cgtgagatct ggttcctatg ccgcaagtac aatgcacagg
    14581 aggctttgga tatgggtctg gtaaataagg tagtcccctt ggataaatta gaggacgagt
    14641 acgttcaatg ggccgaggag atgatgttgc ttagcccgtt ggccttgcgc atgatcaagg
    14701 caggcttgaa cgccgagttg gacggacagg ccggtataca ggagttggcc ggagacgcta
    14761 ccatgcttta ctatatgacg gacgaggcgc aggaaggcgg caaggcattc ttggagaaac
    14821 gccgtccacg cttcgaggat tacccgaagt tcccgtaaag ggaattgaga attgagaatt
    14881 gaaaattgaa aattaagtgg
//
