LOCUS       gnlProkkaOGEMPLPK_49   12422 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OGEMPLPK_49.
ACCESSION   gnlProkkaOGEMPLPK_49
VERSION     gnlProkkaOGEMPLPK_49
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 08:16:29
            Original ID  :: gnl|Prokka|OGEMPLPK_49
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12422
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12422
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2068:2422]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2069..2422
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12422
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12422
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             115..504
                     /locus_tag="ctg49_1"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTSAEAPAPAAEAPAAE"
     CDS             658..2049
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 102.4; E-value: 3.6e-31)"
                     /gene_kind="transport"
                     /locus_tag="ctg49_2"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMAAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGTDATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFVFTVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLVVALLLKKADRKYGYKLEE
                     PNIQK"
     CDS             2069..2422
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_3"
                     /sec_met_domain="PqqD_RRE (E-value: 2e-09, bitscore: 29.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.5e-16, bitscore: 52.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEIPEGKVSLLDAVPVRCGHITTEWEGECAVLAYPRFKYEWMRR
                     FLLPKGMSPDIHVRLEEHGTAVWDLIDGHRTVREIISLLARHFGEEENYIPRVTAYVMQ
                     LRKDGFILLTIRD"
     CDS             complement(2430..3479)
                     /locus_tag="ctg49_4"
                     /transl_table=11
                     /translation="MKKNILILSALFLSTTAIAQTDVTTGVMRGKDYGVTYMLPKTEIE
                     IVLQTTKHTYTPGEFCRYADRYLRLNNVSAEPEEFWTLDKIETRIAGIPDKDNVYFVKM
                     KDKTVAPLMELTEDGIVRSINIPFSDKPAAKMPVAKATESNIDPRSFLTEEILMSNSSA
                     KMAELVAKEIYSIRESKNAILRGEADNMPKDGAQLKLMLDNLNQQETAMTEMFSGKIKK
                     EPKTFTIRLTPKEMKDEVAFRFSKKLGVVANNDLAGEPYYISVTDLKNPDVSATEESKK
                     KVDGVAYNLPGKAQVTLVYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFDTAT
                     GGLIKVDRE"
     CDS             complement(3550..4677)
                     /locus_tag="ctg49_5"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGGQDELAMLVGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSATLPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLSFNRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQVTPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDNPIPHASLEAVNIEEDSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGRLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLTKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVRSVNNL"
     CDS             complement(4771..7743)
                     /locus_tag="ctg49_6"
                     /transl_table=11
                     /translation="MEDIFSKRNTLRTIKADTSDYFIPFFHTLAVFLSIKETIITKRFS
                     EHIMKNLIALTLLLGGSTLLCAQKPAKTPVTYKPVKSEMYRKGWIDFNKNRVKDVYEDP
                     SAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLWKDGIGAIDEHL
                     NGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNEGIRGVESYRAT
                     NFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQRWGRYEEVYGES
                     PYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQMSPREVENIHIY
                     PFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRSEMGFRGYVVSDSDAVEYLYT
                     KHGTAKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRKLVKEGGLSEEVINDRVRDILR
                     VKFLIGLFDAPYQTDLTGADREVEKEENEAIALQASRESIVLLKNAGELLPLDINSTKK
                     IAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKGKAEVLYTKGCNLVDAHWPESE
                     IIDYPLTDDEQAEIDKAVENARQADVAIVVLGGGQRTCGENKSRTSLDLPGRQLQLLQA
                     IQATGKPVVLILINGRPLSINWANKFVPAILEAWYPGSKGGTALADILFGDYNPGGKLT
                     VTFPKSVGQIPFNFPCKPSSQIDGGKNPGLNGNMSRINGALYPFGYGLSYTTFEYSDLD
                     ITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNLAGFQRIHLEPG
                     ETQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLNGTLTVEDYQTRAKAI
                     EVQKPTKRVNASTNPEDAENVLDEKINTVWQGNKGDYITFALKNGAKVDKVAIAFTRDN
                     NLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVLNDDRVGIAEVK
                     F"
     CDS             9024..9509
                     /locus_tag="ctg49_7"
                     /transl_table=11
                     /translation="MKIHEGKCTEKILKERERIGSRLAILRKKRNMTQEELANLCGVNR
                     VNIAKIEKGAYNVSIDILSKVTSALGFVIDIKVDSSVCPTHFSQRKPVKLVIGKDYYVS
                     FGNNEAHRCKLVDIPEMYQGQRIKIETPTPRGSITHILFADEIGTTPDEAVMNQVTM"
     CDS             complement(9709..10506)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 56.4; E-value: 5e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_8"
                     /transl_table=11
                     /translation="MQKRHTDRESYFDEQSQTSKNYYIPYIKEVIGHIPDKVLEVGCGE
                     GGNLLPFAKAGCRVMGVDIDAMRIEQARTFFTQRHQQGQFIATDIFQLEDKATNFPLIL
                     LHDVIEHIRDKERFLSGLQKHLSADGAVFVGFPAWQMPFGGHQQIAHSHIISHFPFLHL
                     LPRTLYRWILRLCGEQERVITELLDIKSTGCTIELFNRIARQANYQIIDRRLYLINPHY
                     KIKFGLSPRRLNGVIAAIPYIRNFFCTSCFYILKKGTKTVNHY"
     CDS             complement(10588..12228)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 69.4;
                     E-value: 4.9e-21)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg49_9"
                     /transl_table=11
                     /translation="MDTKALVTLCQKGNGQALSLLYENYSEKMLKVCLRYIPDPTIAQD
                     LLHDGFVIIFTSIHSLRNPEKLEYWMKKIMRNLALQYLNHANANPTIPLTDIPEEEEPA
                     ENPFCPDFISYDKMLDIVESLPEGYCKVFKLAVLEGLSHKEIGDLLGIAPHSSSSQLFR
                     AKILLKKMLAGYRVFIVLTVLLLFPTLYDYLYREKKSIRENRLSKVSSRQAGSTQQTKK
                     TDTPRTDEQCYTKENLNKRERIIPPVPVSTEWPLAIPKMKDSIHKYPIPSPFTGQTITN
                     RQMAFASSPSLMPPTRKKKSRKWKLMLAGSLGPQLAQNLYKLIATPHTDGISSDFPQQV
                     STWEEYYSYLHTRYQQGTLGKDSIGLMQIAQNNSGRIVENQQHHAPIVVGLSLSKKLNE
                     RWSLETGLQYTLLRSEFTTGEAFRIQDNQKLHYIGIPLRLSYRFWHYKRFSGYATAGMQ
                     VDIPIKGTLQSFHVTDSIPHKLDSQPVSAPWQWSVNTSIGIQYRLTPQAGIYLEPTINY
                     YIPDGSQLRTIRKEHPFTFTLPVGLRISW"
ORIGIN
        1 cacttgaaat tattaaaaaa ttaagtttga attatccaaa aaaaaatgct tactttgcag
       61 accaaatcag atttttggag aaattgatta ttaacgctaa atcaaaataa caaaatgtat
      121 ttattattag ttatcttaat gctgattgca tctgtgctga tgtgcttcat tgtattgatt
      181 caaaattcta aaggaggcgg tctggcatca ggcttttcat catccaacca aattatgggt
      241 gtgcgcaaga ctacggattt tttggaaaaa gcaacttgga ctctggcagc tgtcatggta
      301 gtcttcagta ttgtttctgc ttacactatt ccttcttcca caggtaaggg cggtgatgtg
      361 attctggaac aggcgcaaca agaagaaaaa actaatcctt ataacatgcc cgtaggtaca
      421 gaagctccgc aatcggaggc ccctgcagct acaacttcgg ctgaagctcc tgctcctgca
      481 gcagaagccc cagcagcaga ataagataag gatattgcgg atgactcccg cttggaaaaa
      541 taagagaaag gttgatactg aaaaggtgtc aacctttttt cgttttaatg aagtatttat
      601 ttacctttgt cagcaactta tgcaatctga ttaataaatt gaaatttaaa tagtgcaatg
      661 acagaacaac tcaaacttaa attgaatgat tccaaggcta cccgttgggg ggcattggtg
      721 attgttgcct tcacgatgat ggcagcttat tatgtaaacg acgtggtagc gccattgaag
      781 acaatgttgg aaacggactt ggcttggtcg agtactgatt tcggattctt taccggtggt
      841 tatagtttcc tgaatgtttt tttcctgatg ctgatttggg gaggattaat cctcgaccgc
      901 tttggcatcc gcttcaccgg aaagctggca actatcttga tggtaggtgg tacagcactt
      961 gaatactatg caatgacggg acttgccggt accgacgcga ctttatttgg aatcaatgaa
     1021 atatttggct ataaaacagg ggtgtttgtt gcttttgccg gttattccat ctttggagta
     1081 ggagcggagg tcgctggtat tacagtttcc aaaatcatag ccaagtggtt taaggggaaa
     1141 gagcttgcca cggctatggg ggtacaagtt gctttggcac gtatcggttc gcaggccggt
     1201 tatgcagtag ccattccttt ggcccgtgct ttcggtattt ccacaccggt gttgttgggc
     1261 ttggttctgt tgttgggtgg tatgattgct ttcttcgtct ttacagtgat ggacaagaag
     1321 ctggacaaac agatggaagc tgctgccatt gctgccggta cggaagatga ggaagagaag
     1381 ttctccttta aggatgtgaa gaatattctg gtcaatcccg gtttctggct gatagcattg
     1441 ctgtgtgtat tgttctactc ttgtgtattc ccattccaga aatttgcttc cgagttgatg
     1501 attatcaaat acggtatcaa tgagaatgta gctggtacgt ttgccggact tccggcattg
     1561 ggggcgctga ttctgacccc ggtctttggt ggttttattg acaagcgggg caagtccgca
     1621 tctatcatgc tgctgggttc agccatgctg atatgtgtac attttattta tgctattccc
     1681 gatataaact attggttggt agctattgtg ctgatgataa ttttgggcat cgctttttcg
     1741 ctggtacctt ctgccatgtg gccggctgtg gccaagatat tcccggtaag tcagctgggt
     1801 acggcatacg cattgatttt ctttatccag aatatcggtc tttggggtat tcctacattg
     1861 atagggtggg tgcttgatgc ctattgtata tccggtaaga aacctgatgg aacgaatatg
     1921 tatgattata cggtgcctat gtgcatattt accggtattg cctgcttgtc ccttgtagtg
     1981 gccctactgc tgaagaaggc ggacaggaag tatggttata agctggaaga gcctaatatt
     2041 cagaaataat aggaaaagcg gataccatat gatggaaata cccgaaggaa aagtaagtct
     2101 gttggacgct gttccggtcc gctgtggaca tataacaacc gaatgggaag gtgagtgcgc
     2161 cgtactcgcc tacccacggt ttaaatacga atggatgcgt cgttttttat tgccgaaggg
     2221 gatgtctcct gacatccatg tgaggctgga agaacacggt acagccgtct gggatctgat
     2281 agacggacat cgtaccgtgc gcgaaatcat ttctctactt gccaggcact tcggggagga
     2341 agagaattat attccccggg tcaccgccta cgtaatgcaa ttgcgtaagg atggatttat
     2401 cctgttgacc atccgggatt agaatttctt tattccctat ctacttttat cagtcctccc
     2461 gttgccgtat caaacaacac tttgatggtt gaattcttgt tgaacagtac cggtgcgaga
     2521 tattctacgg tgccgaattg ggtaatggga agttggtcat caaacaattt cttattgtta
     2581 tacaccaatg tcacttgtgc cttgcccgga aggttatagg ctacaccgtc cactttcttt
     2641 ttactttcct cggtggcaga tacatcggga tttttgaggt ctgtgacact gatgtaatac
     2701 ggttcacctg caaggtcatt attagctacc actcctaact ttttggagaa acggaaagcc
     2761 acttcatctt tcatctcttt aggcgtcaac cggatagtga atgtcttggg ttctttcttt
     2821 attttgcccg agaacatttc cgtcatggcc gtttcctgct ggttcagatt gtcgagcatc
     2881 agcttgagct gggcgccgtc cttgggcata ttgtctgcct caccgcgcag gatggcattc
     2941 ttgctttcgc ggatgctgta tatttccttg gccaccagct cggccatctt ggcactggag
     3001 ttggacatca gtatttcttc tgtcagaaaa ctgcgtgggt caatgttgct ttcggtggct
     3061 ttagctacgg gcatcttggc agcaggcttg tcactgaacg gaatgttgat ggagcggaca
     3121 atcccgtctt cagtaagctc cataaggggt gccacggttt tgtctttcat tttgacgaaa
     3181 tagacattgt ccttatccgg tataccggct atacgggttt ctatcttatc cagtgtccag
     3241 aactcttccg gttcggcaga cacgttgttg agacgcagat agcggtcggc atatctgcaa
     3301 aattctccgg gagtgtaggt atgcttggtg gtttgcaata cgatttctat ttctgttttg
     3361 ggcaacatat aggttactcc atagtctttg ccacgcatca caccggtggt tacgtctgtt
     3421 tgcgctatgg cagtggtaga caagaacaga gctgagagta tcaatatatt ctttttcata
     3481 atctacattc gtttagactg atttagctaa gggacaaagt taatgaagtt atctttgcta
     3541 aatattgctt tataaattat taacagatct gacgaattgt acgcaaaccg gcatgtcgac
     3601 tacaatgtcc tgatgagtgt cttctaaaag tccggtaact tcgtttcgtt tatacacctg
     3661 aatgacattg ctgtcacggc aggcggcaag caagtatttg ccgttgggtg taatgttgaa
     3721 gttgcgagga tggatgccgg ttggctgata acctaccttt gtcaaggtcc cattttcggg
     3781 attaacggca aagatggcga tgccgtcttc tttcagccga ttactggcat agaggtattt
     3841 cccgtccgga ctgaggtgga tgtctgcact tccacgggcg gctacggtgt cggctgtaat
     3901 ggtttgtatc tgttccaggc ggccgtcatc gtaactgaag gcgatgactt tgccggacaa
     3961 ctcggtgatg agataggcaa acttcccgtt gggactgaat gtcaggtggc gcgggccgga
     4021 atcctcctca atgttaacgg cttccagaga agcatgagga atagggttgt cggggtgcat
     4081 cacaaagcgc aggatgcggt cggcactgaa gtcggtggcg aagatgtact ttccgtccgg
     4141 tgaaaagacc gtgcaatgga tgtggggagt gacttgtcgt atggcgtcgg gaccggtggc
     4201 agagccttga aagagcgtgt ctgcaggggc caaagtgccg tctttctgta aaggaaagac
     4261 ggacatggtt ccaccgctgt agttggcagt caacacttcc cggccattgg tggccacgta
     4321 gcaggggtcg gcgccgaagg tgggaacggt gttcagcagg cgcagttctc ctgtttcccg
     4381 attgaaggaa agggagctga gggctgctgt gctgtcgttc atttcactga cggcatagac
     4441 aaattcgcca tcttccgagg gaacgaggta ggagggattg ggcaatgtcg ctgaactgag
     4501 cgggacggct gttcccgtct cctgattaaa gcggaaggta tagataccct tgcttgaacc
     4561 attcgtgtaa gtacctacca gcatggcaag ttcgtcctgg ccaccgttag tgccctttgg
     4621 agaagagcca catgctgtca aacctaatcc gagcatacag aaaagaagtg ttttcattaa
     4681 tttaatgtgc taatatgtca atatgctaat gtgccaatgc ccctgcggca tatacagcgc
     4741 agccaattag catattggca cattagcaca ttaaaattta acttcggcaa taccgacgcg
     4801 gtcatcgttc agcacgatgc ggaggtcgct ggcggtagtg cctttgaacg gataggaaat
     4861 cagcttgcca tattcgctga cggtgcccga atatacggtg aggaactgtc cgccaccgcc
     4921 cgagagctgg atttcgaagg ttgccggtag gttgttgtcg cgtgtaaagg cgatggcaac
     4981 tttatctacc ttggctccgt tctttagggc aaaggtaata taatctccct tatttccttg
     5041 ccatacggta ttgatttttt cgtcgagcac gttttcggca tcctctgggt tagtgctggc
     5101 gttcacacgc tttgtcggtt tttggacttc aatggctttg gctcgagtct gataatcctc
     5161 tacggtcagc gttccgttta agcggatgtc ttcggaagag gcgccggcca tgagcacgaa
     5221 gtcgccgggt tccaccaccc atttcatgtc ggcgtccaga agctccaagt gcttgcggtc
     5281 gatggtgaag gatagttcct gggtttcgcc cggttcaagg tggatgcgct ggaaacctgc
     5341 aaggttcttt tcgtaggtgg tgatgctgct cagtacgtcg cggatataga gttgcactac
     5401 ttcatctccg gcgcgtttgc cggtgttggt caccttcagg cggacggtgg cagactcgtt
     5461 tggggtaatg actcgggggg tgatgtcgag gtcggagtac tcgaaggtgg tgtagctcaa
     5521 gccgtaaccg aaggggtaca gtgctccgtt gatgcgtgac atattgccgt tgagtcccgg
     5581 attcttaccg ccgtctatct gtgaagaagg cttgcagggg aagttgaagg gtatttgccc
     5641 tacgctcttg gggaaggtca ctgtcagctt tccgccgggg ttgtagtcgc cgaagaggat
     5701 gtcggccagg gctgttccgc ctttggagcc gggataccaa gcttcgagga tagcggggac
     5761 gaacttgttt gcccagttga tggagagcgg gcgtccgttg atgagtatca gtacgacggg
     5821 cttgcccgtg gcttgtatgg cttgaagcag ttgcaactgc cggccgggca ggtcgaggct
     5881 ggtgcgcgat ttgttttcgc cgcaggtgcg ttgtccgccg cctaatacta cgatggcaac
     5941 atcagcttga cgggcatttt ctacggcttt gtctatctcg gcttgctcgt cgtcggtcag
     6001 aggatagtct atgatttcac tttcgggcca gtgggcatcc actaggttgc agcctttggt
     6061 gtagagcacc tctgccttgc cttttgtctt ttcttgaatg ccttccagta cagtggtcac
     6121 ctctacggca agggggccgt aatgggtcag cgcgtagcct tcttcgttgg cattgggacc
     6181 acagacggca atcttcttgg tggagttgat gtctaagggc aacagctcac cggcattctt
     6241 cagcagaacg atggactcgc gggatgcctg caaggcgatg gcttcgttct cttctttttc
     6301 cacttcacgg tcggcaccgg taaggtctgt ctggtagggg gcatcgaaca gaccaatgag
     6361 gaactttacc cggaggatgt cgcgcacacg gtcgttaatg acttcttcgc tcagcccgcc
     6421 ttccttcacc agtttgcgga ggggaaggac gaaggagtcg ggcgagcgga aggtacagcg
     6481 tacgttcagc ccggcttcca cgctttggcg gacggcttct ttcatgtctt tggcggtgcc
     6541 gtgcttggtg tagaggtatt ctacggcgtc actgtcggat acgacgtagc cacggaatcc
     6601 catttcgcta cgcaggcggg tggtgagcca gtagtagctg ccctgcacgg ggatgccgtc
     6661 gtaatcgttg tacgaactca ttacgcccag catgccggct tcccggatga cgcgtttgaa
     6721 ggggtagatg tgtatgttct ccacttcgcg cggcgacatt tgcgggtcca cgcgtgccat
     6781 gccttcgcgg gcgcctttgt tgttactgta agcggcaaag tgcttgccgg tggcggccac
     6841 ttggtggttg tgctgcaagc cgcgcaccat ttcgatgccc agttcggcta cgaggtaggg
     6901 agattcgccg taaacttctt cgtagcgtcc ccagcgctgg tcgcgtccta cgtcgaggat
     6961 gggggcgtag acgttggtgt agcccagcat gcgggcttcg cgtccggtga tgagtcctac
     7021 ttggcgaatc agttcacggt tccaggtatg tcccagtccc agttgggtgg ggaagttggt
     7081 ggcgcggtag ctttccacgc cgcgtatgcc ttcgttggta aagtctacgg ggatgccgag
     7141 acgggtatct tccacaaaga accgttgcac ctcgttcagt gcccaggcgt ggcgcgaggc
     7201 gggccagacg taggcattgt ccgagggagg cagtccccat tgctggaagc cgttcaggtg
     7261 ttcgtcgatg gcgccgatgc cgtctttcca gagcagctct ttccattcgg gggtggggag
     7321 gtcgtctttc agtacgcgtt tgtagccgta gagggtgacc atttggcagg tcttttcgtc
     7381 cagcgtcatc tgttgcagca ggttttcgat acgtgcttcg agcggggcgg aggggtcttc
     7441 atacacgtct ttcactcggt tcttgttgaa gtctatccaa cctttgcggt acatttcact
     7501 tttcaccggc ttgtaggtta ccggtgtttt ggcaggcttt tgtgcgcaga gcagtgtgct
     7561 tcctccaagc agcagggtta gggcaataag gttcttcatg atatgttctg aaaatctctt
     7621 ggttattatt gtttctttta ttgacaaaaa tacggctaat gtgtgaaaga aagggataaa
     7681 atagtccgaa gtatcggctt ttattgtccg aagggtattc ctcttactaa aaatatcctc
     7741 caagatgcta ccggggagtt caaatcatta ttagacgaaa catatcattc acttttaaaa
     7801 agaaataggg gacactataa taacctgaga agtagatgcg gtcgtggtgt atacaagtat
     7861 tacggctgca tctgttgaac gagggtatat ttatataata ggaatccgtt ggcagaattg
     7921 ttgcttgtac gggagaacat tcttttcaac cttgggatgt ctaaacccaa ccttggttta
     7981 gacatcccaa agttgggttt ggaaaaacca aagtttggga tagattgctt ccttaattct
     8041 ttccggtttt tccgttaact tcagagactt tttccgttaa cttcctatct cttttgtgca
     8101 aatatccatt acagaagata gatattccct cttgcaggca ttaattccgt caacggatac
     8161 tggctttggt agctgtttga acattgatga caatggggtg cacatattgt atgtatggag
     8221 gattattgtt tttatcacga aaagtcagta ttagctaata tttgtaaata tatggtgatt
     8281 gctaataaaa gaatatgtat ctttgtgcca aagaaagcgg tagaggatga aaaataaagt
     8341 agcatttatc cctttttcac cctccctact tagcaatgag ttacgcaatc ttttaaattt
     8401 cagaccgtta taaagtcatg gggttgactg gatttgacag cgggcagaaa tggtaagtaa
     8461 gcatgcagtg cgtcgttgat ttgcacttta atctcagtcc tcaaaatttt atctggcgaa
     8521 actcgttacg ctctcgctgc ttaatcgaag tatagtagat tgaagcttaa tcccggcacc
     8581 aggtgctggg acgtgacatc actcggaagc tgttgctccg aagcattccg ataaagtggt
     8641 gcagtcaaat cggggatagt tcgtgtcagc ctcgtggcgc gggtgaaaat ctagaggata
     8701 agggaacggt tgatggcttt ggttctgccg ctgcacgaaa atttaggcaa agataagcat
     8761 gtagaaagct tatgatttcc tcgtttggac gagggttcga ttccctccag ctccacggat
     8821 atagtaaaaa gaagtttgta agtccttgaa ttccagtaat tcaggggctt tttcttttct
     8881 tctactcccc ctacctttta tattcattta gaaaatagtt gtagtaaatg tgctacaatt
     8941 caaaattaat atctactttt gtctgttcaa aaaccaataa ctattagaag tgggggcaac
     9001 actttaaatt ctgcaacaga tttatgaaaa ttcacgaagg aaaatgtaca gagaagattt
     9061 tgaaagaacg tgaacggatt ggtagtcggt tagccattct tcgcaagaag agaaatatga
     9121 cccaagagga attggctaat ctttgtggtg ttaatcgtgt taatatagcc aagatagaga
     9181 aaggggctta taatgtgagc attgatatac tatctaaggt aacatccgct cttggttttg
     9241 tgatagatat aaaagtggat agctctgttt gtccgactca tttctctcaa cgtaaacctg
     9301 taaagctggt aatagggaaa gactattatg tcagttttgg caataacgaa gcccatagat
     9361 gtaagctggt tgatattccg gagatgtacc aaggtcaaag aattaaaatc gaaactccga
     9421 ccccgagagg gtctatcacc cacatattat ttgccgatga aataggaacg acacctgacg
     9481 aggctgtaat gaaccaagta acgatgtaaa aacattaaaa gggaggaagt gcaagttcct
     9541 cttttattga aatccccctc gctacaacca tctgcagcga gggggatttt ttagtttatg
     9601 agggtttcta cacccactct ttcatcagag ctattcaaaa aattaatgat ttcttctgaa
     9661 tatataatct taaattgatg gttcggaatc aattctaaag ctgggaaatc agtagtgatt
     9721 aacagtttta gtccctttct ttaatatgta aaagcaactt gtacaaaaga agtttcttat
     9781 atacgggata gcagcaataa ctccgttgag ccttcgtggg gacaagccga atttgatttt
     9841 ataatgtggg tttataaggt acagtctccg gtcaatgatt tgatagttgg cttgccgggc
     9901 gatgcgattg aacagttcga tggtgcatcc ggtgctcttt atatccagta gctccgtgat
     9961 tacgcgttcc tgctcaccgc atagtcttaa tatccatctg tataaagtgc ggggaaggag
    10021 gtggagaaaa gggaaatgtg aaataatgtg gctgtgtgct atctgctggt ggcctccgaa
    10081 tggcatttgc caggcgggaa atcctacaaa tacagctccg tcggcagaca aatgtttttg
    10141 taggccggag aggaaccgtt ctttgtctct gatatgctct atcacatcgt gtagaagaat
    10201 caggggaaaa ttcgtagcct tgtcctcaag ctggaaaatg tcggtggcaa tgaactgtcc
    10261 ctgctgatgc ctttgggtga agaaggtcct ggcttgctct attcgcatgg catcaatgtc
    10321 tacgcccatc acccggcaac cggctttggc aaagggaagc agattgcctc cctctccaca
    10381 gcccacttcc agcactttat cggggatgtg tccgatgact tcctttatgt aggggatata
    10441 atagttcttg ctggtctgtg actgttcatc aaagtagctt tcccggtcgg tatgtcgttt
    10501 ctgcatgttc tttgttcctt cttgagtttg attatccata taaatagata atcagtcggg
    10561 taaaagactg cgtggcgcat cgttttttta ccaggaaatg cggaggccta ccgggagggt
    10621 gaatgtgaac ggatgttcct ttcggatggt gcgcagttgg ctgccgtcgg ggatgtaata
    10681 gtttatagtc ggctccagat agatgcctgc ctggggtgtg aggcgatatt gtatgcctat
    10741 acttgtgttg accgaccact gccagggagc acttaccggc tggctgtcga gcttgtgtgg
    10801 aatactgtcc gtgacatgga agctttggag tgttcctttt atggggatat ccacctgcat
    10861 gcctgccgtg gcataaccgg agaaacgttt gtaatgccag aaacggtagg aaagccggag
    10921 agggatgccg atataatgta gcttctggtt gtcttgaatg cggaatgctt cgccggtagt
    10981 gaactccgac ctgagaagcg tatattgcaa tccggtttcc aggctccaac gctcattcaa
    11041 tttcttgctg agagagagtc ccacgacgat gggggcatga tgttgctggt tctcaacaat
    11101 cctgccgctg ttattctggg caatctgcat gagtccgatg gaatcttttc ccagagtacc
    11161 ctgctgatag cgggtgtgca gataagaata atactcttcc cacgtgctga cttgttgagg
    11221 gaagtcactt gaaatgccgt cggtatgtgg agtggcaatc agcttatata agttctgtgc
    11281 cagttgcggt ccgagtgaac ctgccagcat caacttccat ttcctggatt tcttcttgcg
    11341 ggttggcggc attagggaag gggaggaggc gaaagccatc tgccggttgg tgatggtctg
    11401 tccggtgaat ggagaaggta tgggatattt gtggatgcta tctttcattt tgggtatggc
    11461 aaggggccat tctgtggaaa ctggaacggg agggatgatt cgttcccttt tgttcagatt
    11521 ttctttggta tagcattgtt cgtcggttcg gggagtatcg gttttctttg tttgttgcgt
    11581 actcccggct tgtctggaag aaactttgga caaacggttt tccctgatac tctttttctc
    11641 tctgtacaga tagtcataca gcgttggaaa gagaagcaat actgtcaaaa caatgaatac
    11701 acggtatcct gccagcatct ttttaagtaa aattttcgcc cggaacaatt gggaggaaga
    11761 ggagtgtggc gctataccca gtaaatctcc gatttctttg tgggacaatc cttccagtac
    11821 tgccagttta aataccttgc agtagccctc cggaaggctc tccactatat ccagcatctt
    11881 atcgtacgaa atgaaatccg gacaaaaagg attttcagca ggctcttcct cttccggaat
    11941 atctgtcaat gggatggtgg ggttggcatt ggcatggttg aggtattgca gtgccaggtt
    12001 tctcataatc tttttcatcc agtattccag tttctccggg ttgcgcagcg aatgaatgga
    12061 agtgaatatg atgacaaaac cgtcgtgaag aagatcttgg gctatcgttg ggtcgggaat
    12121 atagcgtagg catactttca gcattttctc tgaatagttt tcgtagagca ggctcaaggc
    12181 ctgcccgttt cccttctggc ataaagtgac aagagctttt gtatccatgt gtttgtctca
    12241 atgttatttc ttaaggatag agaagaacat gaatgactgc atggattttt attttttaac
    12301 taagcccccc ggttggcttc tgctgcacag tccggacaaa tgcctttcag tacatagttg
    12361 atgctgttca gtgtaaatcc ttgaggcagc ttcaccaccg gagtgggaat gttggtgaag
    12421 ca
//
