LOCUS       c00016_gnlPro..        13776 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HPFPGLDM_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 10:42:18
            Original ID  :: gnl|Prokka|HPFPGLDM_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 44040
            Orig. end    :: 57816
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13776
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[54040:57530]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13490
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13776
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13776
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             241..759
                     /locus_tag="ctg16_47"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMKKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAHPGA
                     LRENEEAGQ"
     CDS             704..1633
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_48"
                     /sec_met_domain="adh_short_C2 (E-value: 4.2e-75, bitscore:
                     244.2, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTGRTPVHSGKMKRPDSSPPPRFSPLFFHSRHALSPYGFLRGQV
                     HFKLAGTVKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGAKVILISRSPSSC
                     GGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLR
                     MKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKA
                     GLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDI
                     AALTAFLASDDARYITGQVIACDGGMTM"
     CDS             1657..2862
                     /locus_tag="ctg16_49"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPAA
                     GASLRMIAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNVEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAVRRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDVMTMHRLWNFSKG
                     EP"
     CDS             2996..3298
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_50"
                     /sec_met_domain="Acetyltransf_1 (E-value: 3.6e-09,
                     bitscore: 28.9, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVSPSFIPEQDAVAVHGSRIVGNIVDATSVIRADDGKEYEVLGM
                     GAIAVLPEYQSRGIGRRMIGYTRNRVREMGFRAIFLYGDPDYSSRCGFVPAETLG"
     CDS             complement(3426..4202)
                     /locus_tag="ctg16_51"
                     /transl_table=11
                     /translation="MTGAQEQKLKCICWDMATNNYEYRRVYLDKVKTDYGEFSSYNQKN
                     NVYKQLINEINRYDKDFRIETIKWLKNIDSEKENELFAQEIRMMVAMIIKEQSKNGRPN
                     EKIKNQIEINIENKFRKKKNIIVAEAIKKKFLTKIKDRMIALMESSILSIGDRSNYLFW
                     KTNIINAKDCASEDNLLAGNLKTRYENDLIRHRHRCAHNLTSYQQNLPTLSALAENEHR
                     YHNYFFRFTTLILIDEIFMLLYNEYIKQIECNISHI"
     CDS             complement(4336..5640)
                     /locus_tag="ctg16_52"
                     /transl_table=11
                     /translation="MESLDDRVYYGEYSLKHWIDLMLTRNIELPDYQRHFVWQERDMKR
                     LIKSLKEKQFVQPVTIALYDVGEQKRNLILDGQQRLTSILLAYVGYLPDRKKFSDGDNE
                     MLAKEDDSASDESDNSYKHNPILWKFSELLANQNSKEDIIKRIHEDGRYAQLTDKEFID
                     LTDDFFENTFIGFSYIVPESRNPTTVQTVFSKLFRNINYFGRKLDALESRKSLYFQDKN
                     LVNYFEGKTENNSDVLCGIKIMENLQPYKIDFVRYLSILSQYSANCSNERKVLVGYSAF
                     GSRESFYADYVSYILGQGADEQESRPDKFNYFDFREVFPNNCWKQRFLNLKIAIDRLKK
                     IMGLNDRSSFSTWLEADYWLFGLIYHIVFKGSVLKEDLSMEIKKDMSISLKNEIDEKII
                     DKKKDSSNYMKNINRLGNLRERLKDSCEIYGKYVQ"
     CDS             complement(6252..6992)
                     /locus_tag="ctg16_53"
                     /transl_table=11
                     /translation="MKKTLTFLIAMGSFAVSSEAATVFNYYTPGTDNYNSTIYGFYLGL
                     GSSSLAPSDSSSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNT
                     GTTAAGINLTFSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAP
                     TANTEGDTVTISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEM
                     VPEPATVSLGLLGLAALMMRRRRA"
     CDS             7307..8014
                     /locus_tag="ctg16_54"
                     /transl_table=11
                     /translation="MNKLLSTLILSAGMSLSATAATSLLDSSIVGYSDFASQTADFGTR
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLSKINTPVAYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLTALMMRRRRA"
     CDS             8269..8676
                     /locus_tag="ctg16_55"
                     /transl_table=11
                     /translation="MQSPASLSIRNSPSFQQSISPHGPDRCGSVRRQQTPSPKQGKGVG
                     KWLSLNLYPPFPSMNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPDE
                     FLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(8710..9525)
                     /locus_tag="ctg16_56"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(9528..9800)
                     /locus_tag="ctg16_57"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             10001..10702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_58"
                     /sec_met_domain="SucD_FumR (E-value: 2.5e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             10724..12682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_59"
                     /sec_met_domain="FAD_binding_2 (E-value: 4e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.1e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             12660..13490
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.6; E-value: 9.2)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_60"
                     /sec_met_domain="Fer2_3 (E-value: 2.6e-23, bitscore: 74.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 8.3e-11, bitscore: 34.2,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.5e-06, bitscore: 19.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPSAATSKDSQYINTQKKDYNMAKTLNLTLKVWRQENREAKGRIE
                     TYAAKDIPVDASFLEMLDIVNEGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPER
                     QVTTCQLHMRKFKDGDTVWIEPFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAP
                     NANNIAVEKVKADAAFDAAACIGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSK
                     RVLAMMKQMEAEGFGNCTNQYECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
ORIGIN
        1 cattatgaag gaacactggt cttcatctcc cacgatgtgc acttcatccg ttccctggca
       61 caaaaaaccc tgcatgtgaa ccgggggacc atcaccgcct acgcaggcgg atatgactac
      121 tatctggaaa agtcaggcat tctggacgat gaaaaaggcg gcatcacggc ggaataaggc
      181 tcttttttca gtttcccctt tttccttgcc gtggatttca tcctgcctta aaagaacagg
      241 atgaaggctt ttcttgttcc tctcttatat tctgcgcttc tgtccggagc ctctcttgca
      301 tttggtgaaa cggccgccgg aacggcttcc cccgcagcag cggctccggc ggaaaaaatt
      361 ccttccgcgg aatccctgat caaccaggcc ttttcctttg ccatcaatat ccagcagacg
      421 ttggcaggcg ttcaggacaa ggaaagcgcg gacaacgccg tcaaaacgct gcaggacatt
      481 cagaaggaca tccggcattt cctccagctt caggataaat tgaacgatgc ggaaaaggag
      541 aaagaagacg ccttgataga aaaaatgaaa aaacgaatgg aaatgctgga caaccgctgc
      601 aggcaggaag gcaaacgcct gtttgaggcc cgctattacg gttccgccgc cttaaaggac
      661 attttggaaa attcggatga attcagcgac ctggtagaac cggatgaaga cggggcgcac
      721 cccggtgcac tccgggaaaa tgaagaggcc ggacagtagc cccccgcccc gtttctcccc
      781 cctctttttt cattcccggc acgccctttc cccgtatggg ttcctgcgcg gccaagtcca
      841 tttcaagctt gccggaaccg tgaaaaacgg gtttactgtg ggcagcatgc aaaagttagc
      901 aggtaaaaca gccatcgtta ccggcgcggg ccgcggaatc ggcaatgccg tcgcgcgccg
      961 cttcgcttcg gaaggagcca aggtcatcct gatcagccgc agtccatcca gctgcggggg
     1021 ggccgcagaa gaaatcaaca aggaatttcc ggattcctgc aaggcctacc cctgcgacgt
     1081 agcggattac gcggccgttc aggaaaccat ggccgccatt ttgaaagact tcccgcagat
     1141 tgacatcctg gtgaacaacg ccggcatcac gcgggactcc ctgatgctcc gcatgaaaga
     1201 ggaagactgg gatgccgttc tggacaccaa cctgaaaagc gcgttcaata cggtcaaggc
     1261 cctccagcgc gttctcatga aatccccggc cgggcgcatc atcaacatga gctccgtcat
     1321 cggtctcgtc ggcaacatcg gccaggccaa ttacgccgct tccaaggcgg gcctcatcgg
     1381 tttcaccaaa tcactggctc aggaattcgc tccgcgcaaa gtcacgtgca acgccattgc
     1441 tcccggcttc atctccacgg aaatgtccaa tgccattccc gacaatctca aggaagaaat
     1501 cgttaagaaa atacctttga aagaacaagg ttccgtggaa gatatcgccg ccctgacggc
     1561 cttccttgcc tctgacgatg cccgttacat caccgggcag gtcattgcct gcgacggagg
     1621 catgacgatg tagggcattc cggttttctc cattccatgc gcggcatttt ccttgtttcc
     1681 tgctttctgg gaggaagcgc cctgctggcc gggtgccggg aagaaaataa ttccccccgc
     1741 ccggccacgg aagatgccgc gcgcattacc agcgcacgcc aatggggaga aagccgatcc
     1801 gcgctgcaaa aacgggaact ggaccgcgct gccggtcctg cccttcctat tccggatgac
     1861 ctgccgtccc gggagctggt cggcacgacg cgccaaatcc atcagctcat tgaagcttcc
     1921 ggaaatccgg cacgttttga atcctacacg gaaacggttc ccgcggcggg agcttccctg
     1981 cgcatgatcg ccataccggg aggaacgttc ctcatgggga gtcccgcgga agagccgcac
     2041 cggaaaccgg acgaaggacc gcagcataaa gtgagcatct ctcccttctg gatctcggaa
     2101 acggaaatcc cctgggaact ttatacggcc ttcatggaaa acgggcgtcc gcgcgccaag
     2161 gacggccagc ttctggagga acagccggat gacgaactgt gggactccgt tacgcagcct
     2221 accgccccct acaccgccat gaacctgggc atgggccacg gctatgaaca cggtctgccc
     2281 gccatctcca tgtcccacca cgccgccagc aaattctgcg aatggctgag cgcccagacc
     2341 gggcattact accgcctgcc cacggaggcg gaatgggaat acgcctgccg ggccggctcc
     2401 cccggcgcct attcttacgg aaacgtggaa gcctctctgg accagtacgc ctggtactgg
     2461 aacaactcca atgaccgcta ccagaaaaca ggctctaaaa aaccaaataa gtggggactc
     2521 cgggacatgc acggaaatgt ggcggaatgg gttttggact cttacgttcc ggatgcctac
     2581 ggcaaacgga gcggcttgcc cgcgaaagac cctctggtca tcatccccgg cgcccctcac
     2641 atcgttcgcg gcggttcgtg ggaagacgac ccggacagcc tgagaagcgc tgtgcgccgc
     2701 gccagcaccc ccgcctggaa ccgtcaggat cctcaaaacc ctaaaagcat ctggtacctg
     2761 acggacggag gcatgatcgg gttccgcgtg gtgcgcccca tgaacattcc ggacgttatg
     2821 acaatgcacc gcctctggaa tttctccaag ggggaaccgt aaagaacaac ccttcatgac
     2881 cattgcatta agaacggaac aatccgcaga ccatgccaaa acggaacatg tcacgagaga
     2941 agcgttctga aactatttcg tccccggctg caatgaacat tacctgctcc atatcatgcg
     3001 cgtcagtcct tccttcatcc cggagcagga tgcagtcgcc gtccacggca gccgcatcgt
     3061 cgggaacatc gttgatgcaa cgtccgtcat cagggcagac gatggaaaag aatatgaagt
     3121 gctgggcatg ggggccattg ccgttcttcc ggaataccag agccggggaa taggacggcg
     3181 gatgatcggc tacaccagga accgggtgcg tgaaatgggc ttccgtgcca ttttcctgta
     3241 cggcgacccg gactactctt cacgctgcgg attcgttccc gcggaaacgc tgggataata
     3301 tgtatgcagc ggtctcgcat ttgttgcatt aacaaatgtg taatgaaata ttattaatat
     3361 aacaacatta atatatattt cataacaacg tgcattctac aatcaagata caaaaataaa
     3421 aataattata tatgcgatat attacattct atttgtttta tatactcatt atataagagc
     3481 ataaatattt catctatgag tatcaatgta gtgaaacgga aaaaatagtt gtgataacgg
     3541 tgctcgtttt ctgccaaagc actcaatgtt ggaagatttt gctggtaaga agttaaatta
     3601 tgtgcacatc tatgacgatg tctgataagg tcattctcat atcttgtttt taaattccca
     3661 gcaagcaaat tgtcttctga agcacaatct tttgcattaa ttatatttgt tttccaaaac
     3721 aaatagttgc tcctatctcc aatagacaat atggaagatt ccataagtgc tatcattcta
     3781 tcttttattt ttgtcaaaaa cttcttcttt atagcttctg ctacaattat gtttttcttt
     3841 tttctaaatt tattttcaat atttatttca atttgatttt tgattttctc attcggcctc
     3901 ccattttttg attgctcttt tattatcatt gcaaccatca tcctaatctc ttgagcaaaa
     3961 agttcattct ctttttcaga atcaatattt tttaaccatt ttatggtctc tattctaaaa
     4021 tctttatcgt acctattaat ttcatttatc aattgcttat agacattatt tttttgatta
     4081 taagaagaaa attctccata atcagtttta actttatcaa gatacacacg ccgatactcg
     4141 taattatttg ttgccatatc ccaacaaata catttcaatt tttgttcctg agctccagtc
     4201 atttttagaa aaagagattg tactacataa tcgcaaagcg gataagtttc catattacac
     4261 cctacaggta aacaagcatt aacgccgtct ttaaggatat aaaaaatagg agtctttata
     4321 aatttcgaat gaatactatt gtacatactt tccatatatt tcacatgaat cctttagtcg
     4381 ttctcttaaa ttcccaagac gatttatatt tttcatataa ttactactat cttttttctt
     4441 atcgataatt ttttcgtcta tttcattttt aagagaaatg ctcatatcct tttttatttc
     4501 catagataag tcttccttta gcacactacc tttaaataca atatgatata ttaatccgaa
     4561 aagccaataa tcagcctcca gccatgtact aaatgaactt cgatcgttta atcccataat
     4621 tttttttaat cgatcgatag caattttaag attgagaaaa cgttgtttcc aacaattatt
     4681 aggaaaaact tctctaaaat caaaataatt aaatttgtcc ggcctactct cttgttcgtc
     4741 tgctccctga cctaatatgt aagaaacata gtcagcgtaa aaactctcac gtgatccaaa
     4801 cgcggaatat cccacaagaa cctttctttc attactgcaa tttgccgagt attgcgaaag
     4861 aattgataaa taacgaacaa agtcgatttt gtatggctgc aagttttcca taatctttat
     4921 tccacataat acatcgctat tgttttccgt tttcccttca aaataattta ctaaattctt
     4981 atcttgaaaa tataatgatt tacgactttc taatgcatca agcttccttc caaaatagtt
     5041 tatatttctg aacaactttg aaaaaacggt ttgtactgtt gttggatttc tactttctgg
     5101 aacaatatac gaaaaaccaa taaaagtatt ttcgaaaaaa tcatccgtaa ggtctataaa
     5161 ttctttatct gttaattgtg cataccttcc gtcttcatgt attcgcttga tgatatcttc
     5221 tttgctattc tgattagcta ataattcact gaatttccaa agaataggat tatgtttata
     5281 agaattatcc gattcatcag aagcactatc gtcttcttta gctaacattt cattatcacc
     5341 atctgaaaat ttttttctgt ccggtaaata ccctacatac gcaagaagta tagatgtaag
     5401 tcgttgttgt ccatccagaa ttaagttgcg tttttgctcg ccgacatcat aaagagctat
     5461 tgttacaggt tgtacaaatt gcttctcttt aagtgatttt ataagccgtt tcatatctcg
     5521 ttcttgccaa acgaaatgcc tttgataatc aggaagttca atatttcttg taagcattaa
     5581 atcaatccaa tgtttcaagg aatattctcc gtagtatact ctatcatcta atgattccat
     5641 ataaaaaata tttaatggta ataattttat gggcaaattt actattattc tgtaagtcga
     5701 actaaatttc aattatcaaa ttcagcgaat tatgggttac agttactgaa atttatattt
     5761 taattcatac tcttcaagtt ttctgtataa cgttattctt cttattccga gcagtttgga
     5821 agaaacacta cgatttccag ctggtccgtg ttaaggcacg taaaattgtt ccttatcctt
     5881 cgcattattg cacatgacga aattgacggg cgaagccggt ttaatcaatg gtgtatacaa
     5941 cctgcaggta tgatatatac tgcctttttc agaaaactat cagtgtcttg ttctatgtca
     6001 taaactgttt cagttgttcg attaaatccg tagttttgca cttgtactat ttgatacgtt
     6061 tggtgtcatg atgtatgata atataggaaa tagtcaacag taaaataaca aataccatca
     6121 gaccacatat tttcacaaaa agccactcct tcatagcaac tatttttccc ctatataatc
     6181 tttgaaaata aaaaacaagg gctgttcttg cgaaacagcc ctcatccgcc gatttttcgc
     6241 catcaggaag ctcaagccct gcggcggcgc atcatcagcg cggccagtcc cagcaggccc
     6301 agggaaaccg tggctggttc cggcaccatt tcccctcgga tttccgtgaa aatcggggat
     6361 aataagctga aagtattggt tccgttggct cccgtaataa cgacagaatc accaggcgct
     6421 ccctcggcgt cataatggcc gcggatgccg ggagcagtca atccgccgct gatcgttacg
     6481 gtatctcctt ccgtgttagc agtaggggcg gctgttcccc ccgcagcata taaatacgtt
     6541 ttagacgtat cctgcatcaa gtccatcacg gactggctca cggccaggaa acggtatgtc
     6601 aatgccgcat caagaagcag gggagaacca tccagggaag aaaaactgaa cgtcagatta
     6661 atccctgctg cagtagttcc cgtattggtg ctccagccga tgaccgaatt gtcggagcca
     6721 ttcagcacca ggaagccgta agtgacatta gcgcccaaat tgttggcggc tccgcgcagc
     6781 gtaaaactgt ccagtctgat ctctccggac agggaggagg gagaagagga atcggaagga
     6841 gccagggaag aagaccccag gccaagataa aacccataga tggtactatt gtaattatcc
     6901 gtaccgggag tgtaataatt aaaaacggtc gctgcctccg aggaaacagc aaagcttccc
     6961 atcgcgatta aaaatgtcag tgttttcttc atatttatta ttccttttgg atggcaactt
     7021 gtagcgaatt tggaattccc caatcggatt tggaattccc caatcggatt tggaatccgc
     7081 aagcaattaa aaatattaag agttagtata ttgtatttat aattcattga aaataatgat
     7141 tttttaatat ctctggtcct tttgctaaga tgacgggtca gtctttgtta ttcattggtt
     7201 tcatgattga tttggcctct ttttcattac ttgacggatt ccaaattcgt tattcaagca
     7261 caagtacata cattgaacct tgcatcattt tattaagata ctgaccatga ataaattatt
     7321 atccaccctg attctttcgg ccggcatgag cctaagcgct accgcggcta cctctctgct
     7381 ggatagctcc atcgtgggat attcggactt tgcctcccaa acggcggatt tcggcacccg
     7441 gaaagattcc gtttccatca cgtctgacga cagcaatctg acgttatccg ggataacctt
     7501 caacggatac ggtgccaaca accgcgacgt tatgtctgtg acgatggttc ttgacctgtc
     7561 caaaatcaac actccggtcg cctataccgc tctgtttaac gccaaaaaca gcagtgtaag
     7621 ctggggcgtg ggcctgaaca cggaccggaa actccaggga ttatggaaca acacctcata
     7681 cagcgggccc gtcgttgaca ccccgctggg cacggaaggt tccctgacca tttccgtagt
     7741 caccggagat cttggcaccc gcatctattt tggagacagc gctacgtact attccaacag
     7801 cggcctgaaa ttcggcaacc agcaaattga tcagattctc atggacgcag gactggctga
     7861 atccatcgaa cagctctaca ttcacgactc cctcctttcc caggaacaag ttggtcaact
     7921 gatgagtgaa atcgccagca ttccggaacc cgccacggct tccctgggcc tgctgggact
     7981 gaccgcgctg atgatgcgcc gccgcagggc ataagcctgt accgtccgcc tccctatatt
     8041 caaaggccgg ctcacaaaat cgtgagccgg ccttttcctt atccgttcaa acatctgccg
     8101 aaaaaacaga ggggaaaagc ttccatttgc tgcggcaacc tcacggccag cacttgacgg
     8161 aaaaatggca ttcagtctcc cccggtaggg tcatttcaag agcttccggc cccgccccac
     8221 ttccgtacac gccccttttt cccatgccgg gacagccgga accggagcat gcaaagcccg
     8281 gcttccctca gcatccggaa cagcccatcc tttcagcaat ccatttcccc gcacggtccg
     8341 gatcgctgcg gttccgtccg tcggcaacag actccttccc cgaaacaggg aaaaggagtg
     8401 ggaaaatggc tgagcttgaa cctttatccc ccgttcccgt ccatgaacct tcaaaaacag
     8461 cagctgctac tgcgcctgtt ccggtatttc aaaagcagaa aaggagaacc gcgttttttc
     8521 aacaaacgga atatatgcct tctggccgcc gccggcgcct acatcctgac tcccgacgaa
     8581 ttcctgtttg acggaatcgg caggctgggc cttctggatg acgcggcggt catcctgggc
     8641 gccgtcctca ccgtcttttt cccggacggg gactagaggg ccgtaccctc cgccgcgcct
     8701 cgggcggaat tagcgggacg acactttccg gaacttcggg gactgtccca tgaatgtctc
     8761 cggattttcc aggagaagac gttccgtttc ctgccgggaa aaaccgcgcc tgcgtagctc
     8821 gcaggccagg gccgtcagcg ccaggggatc ggaatccccc cagtccgccg cggaattggc
     8881 ccagacacgg tccattccgt acaattccag aatatccgcc gcccgcttgg gattcagctt
     8941 actggtggga taaagggtca gcccggccca gtaaccggcc tccttcacca gcgggaaggt
     9001 atgttcctca cagtgatcca ccagcacgcg gcaagggtcc agatccggac ggtttttcag
     9061 ggcggaaaga atcattacgg tccccttaag cttgtcttcc agatggggag tgtgaatcag
     9121 cacaagctgg ttgaggcgca ccgccagatc cagatgctct tcaaaaatag tcatttcatg
     9181 ggaagtattc cggttcagcc ctatttcccc gatgccgagg acattgggcc ggtcaatgaa
     9241 ctccggaatc agtttcatca catcccgcgc gaaagccacg tcctgcgcct ccttgggatt
     9301 gatgcacagc catgtgtaat ggtccatgcc gaacttggcc gccctggcgg gttcgcattc
     9361 cgtaagctgt acgaaataat cccggaaacc gtccgcggac gaacggtcgt aaccggccca
     9421 gaacgccggt tcccctaccg ccaggcagcc ggcctgcgcc atggcccggt attcgtccgt
     9481 ggtgcggcac accatatgta tatgaggttc tatgaaagcc atcattctta tttgctgagg
     9541 ttcggggctc cgcaggccgc tttggctgcg gcggtttccg gcacggtgtc atccctgtag
     9601 gaaagggctt ccagaatggc ccggacgcgt ccggggccgg atgcggacaa gaggggaaga
     9661 acatccatca gggcatggta gcggaaatcc gcctcccctt ccccgcggtc cacccggtcc
     9721 agaaatgcgg ccacatccag aacgccggcg cgcgccgctg cgaaatccgc gtccagcacc
     9781 tcctttttac ttcttttcat gcacagacga tacgcctatg cggaaagcct cgtcaagccg
     9841 gaacaggcaa caaaatgata accattccaa acttataaac agcaacctct ttccccggtt
     9901 tttcaaaaat ccgaaaagcg ccggaaattc aagaagaggc ttgccatccg ggcttgaacc
     9961 gggcatcctg tgaagacgca tttatttcat tagagcgcct atgaatgcac tagtaaaaac
    10021 catatgtaca ttcgtgacat cctccatcgg ccgcaaaatc attgtggctc tgacggggtt
    10081 atgtttggtc ttgttccttg cgggacacct ggcaggcaac cttctcatct tcggaggccc
    10141 tgaatggatc aacacctacg cccacggcct gcactccatg ccggaagcag ccctctgggg
    10201 aatccgcgcg gggcttgcgg tgatcttcat catccacgtc tggctgacca tccagctgaa
    10261 gctggaaaac catgcggccc gcgaacccta cgtgttcaag aacaccatta aggcaacgct
    10321 ctcctcccgc tacatgatct ataccggttt gaccgtcctg gtgttcctga tctaccacct
    10381 gtaccagtac accctgcgcg tgggatacga ccccgcccag ttcaccacct ttatttccga
    10441 cggtacggtg gaaacctttg acgtgtacaa gatgatcgtg accggattct ccaacgtatg
    10501 gtgctccgcc ttctacatcc tggccgttct gatgctgttc agccatctgc gccacggggt
    10561 acagtccatc ttccagactg tgggcgtcga ttcccgcaaa atccggccct tctacaactt
    10621 tatcgccatc gcctacggcg cgattatctg cctgggcttc atctccgtgc cggtctcggt
    10681 tcttctgggt atcatcaaat aaccatcaac tcctctcaaa gtcatgatta attttcccgt
    10741 aagcgactgg atgccggatg ccaaaattcc ctccggccct attcaggaca aatggtccaa
    10801 gtacaaactt gagtccaaac tgatcaatcc gaacaacaag cgcaagtaca cggtacttgt
    10861 ggtaggttcc ggcctggctg gcgcctccgc tgccgccacg cttgccgaac ttggctacaa
    10921 cgtcaaatgc ttctgctacc aggacagccc ccgccgcgcc cactccattg cggcccaggg
    10981 cggcattaac gcggccaaga actaccagaa cgacggcgac tccgtttacc gcctgtttta
    11041 cgacaccgtt aaaggcggcg acttccgcgc ccgtgaagcc aatgtctacc gtctggcgga
    11101 agtctcctcc aacatcattg accagtgtgt ggcccagggc gttcccttcg gccgtgaata
    11161 cggcggcctg ctggacaacc gctccttcgg tggcgcccag ctcaagcgaa ccttctacgc
    11221 acgcggacag acgggccagc agctcctgct gggtgcctac caggccctgg aaaaggaagt
    11281 ggccaaggga cacattgaaa tgttctcccg ccatgaaatg atggatctgg tgttggtgga
    11341 cggcgaagcc aagggcatcg tcacccgcaa tctggttacc ggcgaaatca aatcctacgc
    11401 aggggatacc gtcctgctct gcacgggcgg ctacggcaac gtgttcttcc tgtccaccaa
    11461 cgcgatgggc tgcaacgtca ctgccgccta caaggcctac aagcgcggtg ccttcttcgc
    11521 caacccctgc ttcacacaaa tccaccccac ctgcattccg gtcaagggcg actaccagtc
    11581 caaactgacg ctgatgtcgg aatccctccg caacagcggc cgcatctggg tgcccaagtc
    11641 ccgtgaaacc gcagaaaaaa tccgtaaaaa ggaaatcaag ccttccgatg ttcccgaaga
    11701 agaacgggac tactacctgg aacgcaagta tccctccttc ggcaacctgg ccccgcgcga
    11761 catttcctcc cgcgccgcca aggaagcctg cgacgacggc cgcggcgtgg ccgtcaccgg
    11821 caagggcgtc ttcctggatt ttgcggatga aatcaagcgc atgggccgcg aatggattga
    11881 cggccaatac ggtaatctgt ttgacatgta cgaagaaatc acggacgacg acccccatga
    11941 aacgcccatg atgatctacc ccgcctccca ctacaccatg ggcggcctgt gggtggacta
    12001 caacctcatg tccaatgtga aggggctgca cgtcctcggt gaagccaact tctccgacca
    12061 cggcgccaac cgcctgggag cctccgccct gatgcagggc ctgtctgacg gctacttcgt
    12121 cattcccgcc acgctgcccg cttacctgac gaccaccaaa cccggcgccg tcaccaccgc
    12181 cgccccggaa ttcaaggctg cggaagacga agtgaaggaa cgcatcaaca agctcctgaa
    12241 tgtgaagggc accaagacgg tggactcctt ccaccgggaa ctgggcctca ttatgtggga
    12301 agactgcggc atggcccgca cggaagaaag cctgacccac gccattgaac gcattcccca
    12361 gctccgcaag gaattctggg aaaacgtgcg cgtaaccggc acggcggacg gcatcaacgc
    12421 ggaactggaa aaagcctgcc gcgtggccga cttcctggaa ttcgcccagc tgctctgcta
    12481 tgacgccctg aaccgccagg aatcctgcgg cgcccacttc cgcgtggaat accagctgcc
    12541 ggacggcgaa gctaagcgca acgacgatga atacgcctat gtagccgcct gggaatacac
    12601 tggcgtggac agcctgcctg ttctccacaa ggaaccgctg accttcgaga acgtgcacct
    12661 tgccatccgc agctacaagt aaagatagcc aatacattaa cactcaaaag aaagattata
    12721 acatggctaa aacactcaat ctcactctca aggtctggcg ccaggaaaac cgggaagcca
    12781 agggccgcat tgagacctat gccgccaagg acattccggt ggacgcctcc ttcctggaaa
    12841 tgctggacat cgtcaatgaa ggcctggtca aggaaggcaa ggaacccatc cattttgacc
    12901 acgactgccg ggaaggcatc tgcggcatgt gctccctaac catcaacggc attccccacg
    12961 ggccggaacg ccaggtgacc acttgccagc ttcacatgcg caagttcaag gacggcgata
    13021 ccgtctggat tgaacccttc cgcgcgaagg ctttcccaat cctgcgggac ctgatggtgg
    13081 accgctccgc cctggaccgc atcatcgccg ccggaggcta tattgacgtg cgtaccggtt
    13141 ccgcgccgaa cgccaacaac atcgccgtgg aaaaagtgaa ggcggacgcc gcctttgacg
    13201 cggccgcctg catcggctgt ggcgcctgcg tggcctcctg taaaaacgcc tccgccatgc
    13261 tgttcacctc cgccaagatc gcccatctca atctgctgcc gcagggccag ccggaacgtt
    13321 ccaagcgcgt cctggccatg atgaagcaga tggaagcgga aggcttcggc aactgcacga
    13381 accagtatga atgtgaagcc gcctgcccga aaggcatcag cgtggacaac atcgcccgcc
    13441 tcaaccgcga cttcatgcgg gccaacgcca aggaaggcct ctgtttctaa agaagattcc
    13501 ttcttaagac gctctgtaaa aactcccggc ggcatcggct gtcgggagtt tttttcatta
    13561 ccaggtttcc ttgaagcagg aataaaatac cagacagttg cttcctcatc gtcgcgcagc
    13621 gtaaaaaatt gttacaccgg aaggcaccca gtaatccagg agaccgtact tggaaatgcc
    13681 ggacgaaacc taagcaggcc ccgtccgaca gcgacggccc catctttctc cgagaaagaa
    13741 aaatattgat tacaggaatt agactgatgc ccggaa
//
