LOCUS       c00033_gnlPro..        14446 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ACLJJELL_33.
ACCESSION   c00033_gnlPro..
VERSION     c00033_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 15:26:55
            Original ID  :: gnl|Prokka|ACLJJELL_33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14446
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..105
                     /locus_tag="ctg33_1"
                     /transl_table=11
                     /translation="IKVANSPETIVKGEDTQLKMAVDELLKEIDSRKK"
     protocluster    1..14446
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[222:4446](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      223..4446
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14446
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14446
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             223..4446
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_2"
                     /sec_met_domain="HGD-D (E-value: 4.1e-29, bitscore: 92.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.6e-35, bitscore:
                     112.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIGIDVGSTTAKLVAVDENDNLLFSKYERHNAKAKETILSFLK
                     ELLSEIGDKDISVRITGSIGMGISEKCSLPFVQEVVAAAKAIQKDYSHVTSMIDIGGED
                     AKVVFFNDAEATDLRMNGNCAGGTGAFIDQMAIILGVNIDELNQLAMNATQVYPIASRC
                     GVFCKTDIQNLIAKNVSRENIAASIFRAVAVQTVVTLAHGCDITTPVLFCGGPLTFIPA
                     LRKAFIDYLSLDEKEIILPANGTLLPALGAALFHLDKEDYCKLSHLIDKIDTTLNGNGN
                     LASTGLEPVFASNEEYEAWKERISRHKMISSGLKAGTQDVFIGIDSGSTTTKIVVLDED
                     SRLLYSYYNINGGNPIKAVEEGLNQLNDECLKQNAVLNIKGSCSTGYGEDLIRSAFQLH
                     SGIIETIAHYMAAHYLNKDVSFILDIGGQDMKVIFVNNGVIDRMEINEACSSGCGSFLE
                     TFAKSLGYSAQEFSLAACHSEAPCDLGTRCTVFMNSKVKQVLREGATINDIAAGLAYSV
                     VKNCLYKVLKLKDISVLGKDIVVQGGTMRNDAVVRAIELLSGAEVARCDTPELMGAFGC
                     ALYAMKHQGESVSLDEIINKAQYSARSLYCKSCDNRCLVIRYEFESGKSYYSGNRCEKV
                     FTNGESSNRKGLNVYRQKEELLFHRSAEIAAPEQIIGIPRCLNMYEEYPFWHTLFTSCG
                     IQVCLSDPSNFRKYEHNARMVMSDNICFPAKLVHSHVQDLIEKKVDRIFMPFVIFERKG
                     MEQNSYNCPIVTGYSEVIKSVQSEGIPVDSPAITFKDRNLLFKQCREYLSGLSVDDRTI
                     QQAFQKAESEQHSFINTLVDYNKNILQQTGKGETLTVMLAGRPYHTDSLIQHKVSDMLA
                     DMGVNVIADDLVRQMDIPTDDAHFVAQWAYTNRILKAAKWCATQGKNIQFVEMTSFGCG
                     PDAFLVDEVRDLLMRHNKSLTLLKLDDINNIGSMKLRVRSMIESLKLANADGTEDGVKD
                     FTTVPVYDKSYRDRKILVPYFTPFISPLIPAIMKVAGYDAENLPLSDNDSSEWGLKYAN
                     NEVCYPATLIVGDIIKALKSGKYDISKIAVAITQTGGQCRASNYISLIKKALVDAGYTD
                     IPVISISVGSDIDNDQPAFKVNWMKVVPITFHAVLYSDCIAKFYYASVVREKEAGASAK
                     LRDKYLQLAPEVILRRDIKGLNSLLQSAITEFNEVCRAVDTPKVGIVGEIFLKFNPFAQ
                     KEIIDWLIGRKIEVVPPILADFFMQGFVNRKVNTDSYIKNRQLPEFIYDWIYKFVKKQI
                     DKINETASKFRYFAPFNDIFEEAEGAKSVISLNAQFGEGWLLPAEIVSYARQGVNNVVS
                     LQPFGCIANHIVSRGVEKRIKSFYPDINLLSLDFDSGVSDVNITNRMLLFIDNLKNATM
                     NYDNN"
     CDS             4433..5056
                     /locus_tag="ctg33_3"
                     /transl_table=11
                     /translation="MTTTNNNEDLEKKIIEAAKELFIENGFAETSMSDIAAKVGINRPA
                     LHYYFRTKDKMFQAVFGNIILSFIPKIHDIIIQQDKPVSESIGEIVDAYYKVFTENPCL
                     PLFMVREMHRDMNHLSTTIKELRLEQYLHKIMDVLQEEMNDGRLKTVPLPFVFYTFYSA
                     LTVPFLTKNLSASFFLEKDDSFEDILVQWKPYIVRQMETLLVAS"
     CDS             complement(5064..5735)
                     /locus_tag="ctg33_4"
                     /transl_table=11
                     /translation="MGMKDVFKRYLVFVIGLYFLAAGIVLIVRSALGTTPISSINYVLS
                     LNSPLSLGTCTFLINMLLILGQFWIIRKNKTRQDTIEILLQLPFSFIFSAFIDFNMALT
                     SNLHPDNYGISIALLLTGCMIQSIGVVLELKPKVAMMSAEAFVKYASRRYNKEFGKFKV
                     CFDVTLVTLAVILSLLLSQCIEGVREGSLIAACITGYIVSFLNQKIMTRKTLYKLLPVL
                     K"
     CDS             5893..6783
                     /locus_tag="ctg33_5"
                     /transl_table=11
                     /translation="MVKSRIFDNKQLLKEHPEIPHYKEEVVCFMSEYKDRSYPENERYF
                     NRELYMILVLEGRSEILLNGEFIVIEPDMLLVHGANYLTDHLYSSPDIKFITLSISESM
                     RTDDSYLTQITAILLATMRQNKQYTIQLTAYEAQIIRNELEVLMHLLNIKHQFLFRRIQ
                     AACNALFLDIADFLSRKTIIKKEVSRKDHVLQEFHALVTRNFREEHFVSFYADKLAISE
                     QYLARIVRAGTGKSVNTIINELLIMEARTLLSSTKSTVGDIASQLGFSDAAGFCKFFKR
                     NMGQTPLNYRKGLWI"
     CDS             complement(6870..8627)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_6"
                     /sec_met_domain="Transketolase_C (E-value: 7e-17, bitscore:
                     51.3, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 2.1e-18, bitscore:
                     56.4, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Transketolase_N (E-value: 4.7e-08,
                     bitscore: 22.0, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYLENIYSPADVKKLSFQELNDLSHEIRASLLQKLSEHGGHFGPN
                     FGMVEATIALHYVFNSPKDKIVYDVSHQSYVHKMLTGRKDAFLHPAEYDHVSGYSEPQE
                     SEHDFFVIGHTSTSISLASGLAKGRDLTGGNENIIAVIGDGSLSGGEAFEGLDYVAELG
                     TNMIIIVNDNQMSIAENHGGLYKNLKDLRDSNGQCECNFFKAMGLDYMYVNDGNHVEAL
                     IEAFSKVKDIQHPIVVHINTLKGKGYEPAEQDKETYHWRTPFDLETGESKMNDDAEDYS
                     EVTAQYLLKKMKEDKRVVTITSGTPAVLGFTPDRRQEAGKQFVDVGIAEEHAVALASGI
                     AANGGKPVYGVYSTFIQRSYDQLSQDLCINNNPAVLLVFWGTLSGMNDVTHLCFFDIPL
                     ISNIPNMVYLAPTCKEEYLAMLEWSIRQNEHPVAIRVPATDVISCGEPVESDYSNLNRY
                     KVAHRGSKVAILALGSFFGLGQSVLSLLKDKANIDATLINPRYITGVDSELMDELKADH
                     ELVITLEDGVLDGGFGEKIARYYGATDIKVLNYGAKKEFVDRYDIQELLRANHLTDEQI
                     VEDILSLIG"
     CDS             9035..10066
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MKRILLLTAVFIMMLGTSFSFAQADADNFYKSDWVKVEKVSFSNQ
                     YKMKVAGNLFLPKTMKEGEKYPAIIVGHPMGAVKEQSANLYATKMAERGFVTLSIDLSF
                     WGASEGEPRNAVLPEVYAEDFSAAVDFLGTRPFIDRNNIGVIGICGSGSFAISAVKIDP
                     RLKAIATISMYNMGTASRNGLKHALTLEQRKQIMAEAAEQRYAEFLGGETKYTGGTVHE
                     VTENSGPIEREFYEFYRTQRGEFTSEGATPMTTTHPTLSSNVKFMNFYPFADIETISPR
                     PMLFITGENAHSREFSEDAYRLAAEPKELYIVPGAGHVDLYDRVGLIPFDKLESFFKEY
                     LKK"
     CDS             10116..10979
                     /locus_tag="ctg33_8"
                     /transl_table=11
                     /translation="MKQIKNTHYEGERPLFASHGLYLEEVTIHAGESALKECSDIEAVN
                     CRFEGKYPFWHNDGFVVKNCLFTEGARAALWYSRNLKMKDTLVEAPKMFREMDGVELEN
                     VQLPNALETLWYCRNVELNNVKIDKGDYLFIHGEDIRIKNFVLNGNYSFQYCKNVEIRH
                     AEIHSKDAFWNTENVTVYDSVLDGEYLGWHSKNLRLVNCKISGTQPLCYAHDLIMENCT
                     MADDADLAFEHSSVKATIKGPVHSVKNPRTGNIVAESFGTIILDENLKAPGNCELKLWD
                     GLTCFD"
     CDS             10985..11767
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_9"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2e-32, bitscore:
                     102.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYNFDEIVPRRGTNSYKWDSAGDADVLPMWVADMDFRTAPSVVE
                     ALKRRVEHGIFGYVRVPDTYYEAITGWFAGRHGWQIEKEWIIYTTGVVPALSAVIKALT
                     TPGDKVIVQTPVYNCFFSSIRNNGCEVAANPLIYTDGTYQMDFIDLERKAADPSVKVLL
                     LCNPHNPAGRVWTKQELTRLGEICLRNNVWVVADEIHCELVFPGHTYIPFASVSEEFLM
                     HSVTCTSPSKAFNLAGLQMTGKNGWKNLTNTCLPTTIV"
     CDS             11806..12045
                     /locus_tag="ctg33_10"
                     /transl_table=11
                     /translation="MPLEGTYLVWVDCSTLKQSSEDIVKTLLEKEKLWVNEGNLYGEAG
                     EGFVRINIACPRQRLIEGLNRMRRALSSPITSFT"
     CDS             complement(12059..12967)
                     /locus_tag="ctg33_11"
                     /transl_table=11
                     /translation="MEENTKEMIVIDSVDRYNEIFGLETRHPLVSIIDLAKSTTWPTRA
                     WFRYEVYALYLKNVKCGDIKYGRQYYDYQDGTIVCFAPGQITDLEMLPNIQPNAHGILF
                     HPDLIRGTALGQEIKKYSFFSYEINEALHISEEERQTVMDCLQKITIELEHSIDKHSRR
                     LICANIGLLLDYCMRFYERQFDTRNGVNKDIIVRFEHLLNEYFEGDAPQKQGLPSVKYF
                     ADKVFLSANYFSDMVRKQTGKTVSEYIQDKMIGLVKEQLLSTDKTTSQIAYEIGFQYPQ
                     HLSRMFKRIVGMTPNKFRLQP"
     CDS             13174..14190
                     /locus_tag="ctg33_12"
                     /transl_table=11
                     /translation="MLTMMPMAACDGSNADPILPEQPGQPGNSDGGDEDDSTDPTNPIP
                     GGNGRYLVLYCSRTGSTERMAQQIQQTLDCDILEVEPQTPYESDYNGMLNRAQEELAAI
                     RQGNYPAIKTSVEDFGNYDIVFVGYPIWYGSMATPMQTFLHNHASKLAGKRIALFASSG
                     SSGISASVDEARTLCSGATFTETLLLTSSTLSQMGNRIRTWLETLGASRENNYPSTSMN
                     VKITVGNRTITATMEDNAAAQDFLSRLPLEVMLNDYNNITEKIFYPSPALTTAGVTRGC
                     APVPGDITIYVPWNNVAIFCKSGSQSNDLIKIGRIDGDGIDALNVPGNVAVKFERQS"
ORIGIN
        1 atcaaggttg ccaacagccc ggagactata gtgaaaggag aggatacgca acttaaaatg
       61 gctgtggatg aattgcttaa agaaatagat agtcggaaga aatagacatc gttcgtttgt
      121 gttaaaagaa ccgaaaaaaa agcttattga aatgatgtgt ccaacttatt cttacttttg
      181 tgtttgacaa tagtgtcaaa ctaggggaac atagtgtaga acatgattaa aataggaatt
      241 gatgtaggtt caacgacggc gaagttagtt gccgtcgatg aaaatgataa tctattattt
      301 tcaaagtacg agagacacaa tgcgaaagca aaagagacaa ttctatcatt cttgaaagag
      361 ctgttatctg aaatcggaga taaagatatt tccgtgagga taacaggctc tatcggaatg
      421 ggaatttcag agaaatgttc gttgccgttt gtacaggagg ttgttgcggc agcgaaagcg
      481 atacaaaagg attattctca tgtgacttcc atgatagaca tcggaggaga agatgcgaaa
      541 gtcgtcttct ttaatgatgc cgaagcgacc gatttgcgta tgaacggcaa ttgcgcagga
      601 gggacgggtg cttttattga ccagatggcg attatactgg gagtgaatat tgatgaattg
      661 aatcaactag ccatgaatgc gacacaggta tatcctattg cctcccgttg tggcgttttc
      721 tgtaaaacgg atattcagaa tctgatagct aaaaatgtaa gtcgtgagaa tattgcggct
      781 tccatctttc gtgcggtagc agttcaaacg gtagtgacgc tggcgcacgg ttgcgatatt
      841 acaactcccg tattgttttg tggtggtccg ttaaccttca ttccggcact gcggaaagcc
      901 ttcattgatt atttgtccct cgatgaaaaa gagatcatac tgccggccaa cggcactttg
      961 ctccctgcac taggtgctgc tctatttcat cttgataaag aggattactg taaactgtcc
     1021 catttgatcg ataagattga cactacttta aacggtaacg gtaaccttgc ctcaacagga
     1081 ttggaacctg tttttgcaag taatgaagaa tatgaagcat ggaaagaaag aatatcccgt
     1141 cataagatga tatcttccgg cttgaaagcc ggaacacagg atgtctttat cggcatcgat
     1201 tcaggttcta ctacgacaaa gattgttgta ctggatgaag attcaaggct tctgtattct
     1261 tattataata ttaatggcgg caatccgata aaagctgtgg aagaggggct gaatcagttg
     1321 aacgatgaat gtttgaagca gaatgccgta ctcaatataa aaggaagctg ttctaccgga
     1381 tatggggaag accttatcag gtctgccttt cagcttcatt cggggattat cgaaacgatc
     1441 gcccattata tggcagcgca ttatctgaac aaggatgtgt cttttatcct cgatatcggc
     1501 ggacaggata tgaaggttat ttttgtgaat aatggcgtga ttgaccggat ggagattaat
     1561 gaagcatgct cttccggatg tggttctttt cttgaaacgt ttgctaaatc tctggggtat
     1621 tcggcacaag agttttctct ggcagcctgc cattcggaag caccgtgtga tttgggaaca
     1681 aggtgcaccg tttttatgaa ctcaaaagtg aaacaggtac tcagggaggg ggcaacgatc
     1741 aatgatattg ccgccggact ggcatattcc gttgtcaaga attgcctgta taaggtgttg
     1801 aaactgaaag atatatctgt tttgggaaaa gatattgttg tgcagggagg caccatgcgc
     1861 aatgatgcgg tggtccgtgc cattgaactt ctctcgggag cggaagtggc aaggtgtgat
     1921 acacccgaat tgatgggagc attcggatgt gcattatatg cgatgaaaca tcagggggag
     1981 tccgtatcat tggatgagat tatcaataaa gctcaatatt cggcacgttc tttatattgc
     2041 aagagttgcg ataatcgttg tctggtcatt cgttacgagt tcgaaagcgg caaaagttat
     2101 tattcgggaa acaggtgcga gaaagttttc acgaatggag agagcagtaa ccggaaaggt
     2161 ctgaatgtct atcggcaaaa agaagagctt ttgtttcatc gcagcgcaga gattgcagca
     2221 cccgagcaga ttatcggaat cccccgatgt ctgaatatgt acgaggaata tccattctgg
     2281 cacactcttt tcacttcctg tggcatacaa gtctgtttgt ctgatccgtc caatttcaga
     2341 aagtatgagc acaatgcgcg tatggtgatg tcggacaata tctgctttcc ggctaagctg
     2401 gtacatagtc atgttcagga cttgatagaa aagaaggtcg accggatttt tatgcctttt
     2461 gttattttcg aaagaaaagg gatggaacaa aacagttata attgtccgat tgtgacaggt
     2521 tattcggagg ttatcaaaag tgtgcagtcc gaaggtatac cggttgattc ccctgcaata
     2581 actttcaaag accggaatct gttgtttaaa caatgccgtg aatatctgag cggtttgagc
     2641 gtggacgatc ggacgattca gcaagcattc caaaaagcgg aaagcgaaca gcactctttt
     2701 attaatacat tggtcgatta taacaaaaac atattgcagc agactggaaa gggagagact
     2761 ttgactgtca tgcttgccgg acgtccttat cataccgatt ctctgataca gcacaaagtc
     2821 tcggatatgc ttgcggatat gggagtgaat gtgatagcgg atgatttggt gcgtcagatg
     2881 gatataccga cggatgatgc gcattttgtt gctcaatggg cgtatacgaa ccgtatcctg
     2941 aaggctgcga aatggtgtgc gacacaagga aagaatattc agtttgtaga gatgacttcg
     3001 ttcggatgtg gaccggatgc ttttctggtg gatgaagtaa gggatttgct gatgcgtcat
     3061 aacaaatcgc tgaccttatt gaaactggat gatatcaata atatcggttc aatgaagttg
     3121 agagtacgtt ccatgattga aagcctcaaa cttgcgaatg cggatggaac ggaagacggt
     3181 gtaaaggact ttacgaccgt tcctgtttat gacaagtctt accgtgaccg taagatactc
     3241 gttccttact ttactccgtt tatttcacct ttgattcctg ctattatgaa agtagccggt
     3301 tatgatgcgg aaaaccttcc tctcagtgat aatgattcaa gtgaatgggg gttgaagtat
     3361 gcgaataatg aggtctgtta tccggctact ctgatagtcg gcgatattat aaaagcactt
     3421 aaaagcggga aatatgatat ttcaaaaata gccgtagcca tcacccaaac gggaggacaa
     3481 tgccgtgcca gcaactatat ttccttgata aaaaaggcgt tggtggatgc cggatatacg
     3541 gatattccgg taatctctat ctctgtgggc agtgacatag ataatgacca gcccgcgttc
     3601 aaggtcaact ggatgaaagt agtaccgata acttttcatg ccgttttgta tagtgattgc
     3661 attgctaagt tttattatgc gtctgtggta cgtgagaaag aagcaggtgc atcggcaaag
     3721 ctgcgtgata aatacctgca actggcacct gaagtgatac tgagaagaga cataaagggg
     3781 ttgaactctt tgttgcaatc ggcaatcact gaatttaatg aggtatgtag ggctgtagat
     3841 actcctaaag tcggaattgt aggagaaatc ttcttgaaat tcaatccttt cgcacaaaaa
     3901 gagatcattg attggctgat aggccgcaag atagaagtgg ttccgccgat tctggctgac
     3961 tttttcatgc aggggtttgt gaacaggaaa gtcaatacgg attcttacat aaaaaacaga
     4021 cagttgcctg agtttattta cgactggatc tacaagtttg taaagaaaca gattgataaa
     4081 ataaatgaga cagcaagtaa gttccgttac tttgccccct tcaatgatat ctttgaagaa
     4141 gcggaaggag ctaaaagcgt tatttcgctg aatgcccaat tcggtgaagg ctggttgttg
     4201 ccggctgaaa tcgtgtctta cgcccggcaa ggggtgaaca atgtagtgag tttgcaacct
     4261 tttggctgca tagcgaatca tatcgtatcc agaggagtcg aaaaacgtat aaaaagtttc
     4321 tatccggata taaatttgct atctttagac tttgatagtg gtgtgagcga cgtaaacata
     4381 acaaaccgta tgcttttgtt tattgataat ctgaaaaatg cgacaatgaa ttatgacaac
     4441 aactaataat aatgaagatt tggagaaaaa gataattgag gctgccaaag aactatttat
     4501 agagaatggg ttcgcagaaa ccagtatgag tgatatcgct gctaaagtag gtatcaacag
     4561 accggcactt cactattatt tccgaacgaa ggataagatg tttcaggccg tttttggtaa
     4621 tatcatactt tcttttattc ccaaaataca tgatataatc attcagcagg acaaacctgt
     4681 ctccgagagt atcggtgaaa ttgtagatgc ttattataaa gtattcacgg aaaatccatg
     4741 tttgccattg ttcatggtga gggagatgca tcgtgatatg aaccatttaa gcactactat
     4801 caaggagttg cgcctggaac aatatctcca taaaatcatg gatgttttac aggaagaaat
     4861 gaatgacggg agactgaaaa cagttccttt gccattcgta ttctatactt tttatagtgc
     4921 attgacagtt cctttcctga caaagaatct cagtgcttct ttctttttgg agaaggatga
     4981 ttcttttgag gatattctgg ttcagtggaa accttatatc gtcaggcaga tggaaacgtt
     5041 gctggtagcg agctagagaa aacttatttc aatacaggta ataatttgta gagagtcttc
     5101 cttgtcatta ttttctgatt caggaaactg acgatatatc cggtgatgca ggcggcgata
     5161 agagacccct cgcgaacacc ttcgatgcat tgcgaaagca ggagagagag tatgactgcc
     5221 agagtgacca gcgtaacatc aaaacagact ttgaactttc cgaactcttt gttataacgg
     5281 cgggaggcgt attttacgaa agcctctgcg ctcatcattg ctactttggg tttgagttcg
     5341 agtacgactc ctatggattg tatcatgcat cctgtgagta ataaggctat tgatatcccg
     5401 taattgtcgg gatgcagatt actggtgagt gccatattaa aatcaatgaa tgctgaaaag
     5461 ataaaagaga acggcaattg aagaagtatt tcaatggtgt cctgtcgggt cttatttttt
     5521 ctgatgatcc agaactgtcc cagaataagc agcatattga tcagaaacgt acaagttcct
     5581 aatgataaag ggctgtttag gcttaacaca taattgatgc tggatatagg tgtggttcct
     5641 aatgcggaac gtacaatcaa cactattccg gcagccagaa aatacaatcc gataacaaat
     5701 accaaatacc ttttaaaaac gtctttcatt cccatatctt atctatctta tataatcgta
     5761 ttgttcttca ttctataaag aagaatatgc aaaggtcccg tttttttgtc tgatataagt
     5821 tatccgattc cacacagttt ttgtcatatc cgaaacaaat tgtactttta cgtcgaaaag
     5881 aaggaggtat aaatggtaaa atctcgtatt tttgataata agcagttatt aaaggaacat
     5941 ccggaaattc ctcattataa agaggaggta gtctgcttta tgagtgaata taaggacagg
     6001 agctatccgg aaaacgaacg ttactttaat cgtgaacttt atatgatact cgttcttgaa
     6061 ggtcgttccg agattttgtt gaatggggaa tttattgtga tagagcctga tatgttgctt
     6121 gttcatggag cgaattatct caccgaccat ctttattcga gtccggatat taagtttatc
     6181 accctctcca tttccgagtc catgcggaca gatgactctt atcttaccca gataacggct
     6241 attctgttgg caacgatgag gcagaataag caatatacca tacagctgac agcatacgaa
     6301 gctcaaatca ttcgtaatga actggaagtg ttgatgcatt tgctgaatat aaaacatcag
     6361 tttcttttcc ggcgaataca ggcggcttgc aatgccttat ttttggatat agccgatttt
     6421 ctttcccgaa agaccatcat aaaaaaggag gtcagtcgta aagaccatgt tttacaggaa
     6481 tttcatgcgc ttgttacccg aaacttcaga gaagagcatt tcgttagttt ctatgcggat
     6541 aagctggcca tcagtgagca gtaccttgcg cgtatcgttc gtgccggaac gggaaaaagt
     6601 gtgaatacga ttattaatga gttattgatc atggaagccc gaaccttgct gagttccact
     6661 aaatctacgg taggggatat tgcttctcag ttgggcttta gcgatgctgc cggtttctgt
     6721 aagtttttca agagaaatat ggggcagact cctctcaatt atcggaaggg attatggatt
     6781 taagtgaaaa tgaatgcagg ttgatgtgat cccataacga acggatacat caacctacat
     6841 gaaatatata atgaactggt tttgacttat cagccaatga gtgataggat atcttctacg
     6901 atctgttcat ccgtcagatg gttggcacga agcagttcct gtatatcata acggtctaca
     6961 aattcttttt tagctccata gttgagcact tttatatctg tagcgccata gtaacgggca
     7021 atcttttcac cgaaaccacc atccagaact ccgtcttcca gtgtaatcac taattcgtgg
     7081 tcggctttca gttcgtccat cagttcgctg tctacacctg tgatgtagcg gggattgata
     7141 agggtggcat caatgttggc tttatctttc agcaatgaca gaaccgattg ccctaatccg
     7201 aagaaggagc ctaatgcaag aattgctact ttggagccgc ggtgggcgac tttataacga
     7261 ttgagattgc tatagtcgga ttccaccggt tcaccgcaac tgattacatc tgtggcaggt
     7321 acacggatag ctaccggatg ctcattttgg cggatgctcc attccagcat ggctagatat
     7381 tcctctttac aggttggtgc tagatagacc atattgggga tattgctgat aagtggaata
     7441 tcgaagaaac agaggtgggt tacatcattc ataccggata acgtccccca gaataccaac
     7501 agaactgccg gattattatt gatgcagaga tcttgcgaga gctggtcgta agagcgttgt
     7561 ataaaggtgc tgtacactcc gtaaaccggt tttccgccat tggctgcgat accggaagca
     7621 agtgccactg catgctcttc ggcaataccg acatctacaa actgcttgcc tgcttcctga
     7681 cgacggtcgg gagtgaagcc cagaacagcg ggggtgcccg aagtaatggt aactacacgc
     7741 ttgtcttctt tcatcttttt cagcagatat tgagcggtta cttcactata atcttctgcg
     7801 tcgtcgttca tttttgattc tccggtttct agatcaaacg gagtacgcca gtgataggtc
     7861 tccttgtcct gttctgcagg ctcgtaacct ttgcctttta atgtattgat gtggactact
     7921 atcggatgct gtatatcttt aactttggag aaagcctcga tcagtgcttc cacatggttg
     7981 ccgtcattca cgtacatata gtccagcccc atcgctttga agaagttgca ttcacattga
     8041 ccgttactgt cgcgcaaatc tttcagattc ttgtataaac ctccgtgatt ttcggcaatg
     8101 gacatctggt tgtcattgac aataataatc atgttagttc cgagttctgc tacgtagtcc
     8161 agtccctcga aggcttcgcc tccgcttagt gaaccgtcgc ctattacagc gatgatattt
     8221 tcgttgccac ctgtcaggtc acgtcctttt gccagtccgc ttgccaagct gatcgaagta
     8281 gaagtatgac cgatcacaaa gaaatcatgt tcactttcct gtggttctga gtagccggat
     8341 acatggtcat attcagcagg atggagaaaa gcatctttac gtccggtcag catcttatgt
     8401 acgtaactct gatgtgatac atcatataca attttatctt tcggtgaatt gaaaacatag
     8461 tgcagggcaa tggtcgcttc taccattccg aagttagggc cgaagtgccc gccatgttca
     8521 ctcagttttt gtaagaggga tgcacggatt tcgtgactta aatcattcag ttcctgaaac
     8581 gataacttct ttacgtctgc gggagagtaa atattttcta aatacatatc aaattgtttt
     8641 tttatgttta tacctatatt tttatttcac tgcaaagata ctgccggatt tgaaatctgt
     8701 ttgtatatga attacggatt ctttttacct atattacagt tccgctaaaa atgggcttga
     8761 taaaacataa aatatgactt cctctatatc aaccatgtgc tcttttgcaa gcttgattct
     8821 tttctcctga atatactttg gataaggtat cacgcacgcg taatcattat atataatagt
     8881 atatactctt atgtgcggca aaaagataaa accgataatc cgtaattggg gtaataatgt
     8941 cagtaattca tctacaaaca ctctctttat ttcaccgtat ttttgcaatg tagaaagtag
     9001 acaatcaatt cattaataat taaatgtaag agatatgaaa cgaatattat tattaaccgc
     9061 tgtatttatt atgatgcttg gaaccagttt ttctttcgca caggctgatg cggataactt
     9121 ttataaaagt gattgggtaa aggtagaaaa ggtttctttt tctaaccagt ataaaatgaa
     9181 agtagccggc aacctgtttt tgccgaagac catgaaagag ggagagaaat atcctgccat
     9241 tattgtcgga catccgatgg gagcggtcaa ggaacagagt gcgaacctgt acgctaccaa
     9301 aatggcggag cgtggttttg taacgctgtc catcgacttg tctttttggg gtgcaagtga
     9361 aggtgagccg cgcaatgctg ttttgccgga ggtatatgcg gaggatttca gtgccgcagt
     9421 agattttctg ggtacacgtc cgttcatcga ccggaataat ataggtgtaa tcggaatttg
     9481 tggcagcgga agtttcgcta tcagtgcggt caagatagac cctcgtctga aagcgattgc
     9541 aaccatcagc atgtacaata tgggtacagc cagtcgtaac ggactgaaac atgcgctgac
     9601 tctggaacaa cggaaacaaa tcatggctga ggcagcagaa cagcgctatg cagagttttt
     9661 gggcggagaa actaaatata ccggtggcac tgtacacgaa gtgacagaaa actccggtcc
     9721 gatagaacgc gaattttatg agttctaccg cactcagagg ggagagttta cttccgaagg
     9781 agcaaccccg atgactacca cacatcctac gctttcgagc aatgtgaaat tcatgaattt
     9841 ctatcctttc gcagatattg agactatttc gccccgtcct atgcttttca taaccggaga
     9901 aaatgcccac tcacgcgaat ttagtgaaga tgcctaccga ctggctgctg agcccaaaga
     9961 actgtacatt gtacccggtg caggtcatgt agacctttac gaccgtgtgg gtcttatacc
    10021 attcgataaa ttggaatcct tttttaagga atatctgaaa aaataagcat gaacaggaaa
    10081 aacagataac tatttaaata aaagacaatc gaatcatgaa acaaattaaa aatacacatt
    10141 acgaaggcga acgtcctttg ttcgcatccc acgggcttta tctggaagaa gtaaccattc
    10201 atgccggcga atcggcattg aaagagtgta gtgatataga agcggtaaac tgtcgtttcg
    10261 agggaaaata tccgttttgg cacaatgatg gttttgtagt taaaaattgc ctttttaccg
    10321 aaggagcacg tgccgcactc tggtactcca gaaatctgaa gatgaaggat acattagtgg
    10381 aagcaccgaa gatgtttcgc gaaatggacg gagtcgaact cgaaaatgta cagttgccca
    10441 atgctttgga aacactctgg tattgccgga atgtggaact gaacaatgtg aagatagata
    10501 aaggagacta tctctttata cacggagaag acatccgcat caagaatttt gtattgaatg
    10561 gtaattactc cttccaatat tgcaagaacg tagaaatccg tcatgctgaa atccattcga
    10621 aggatgcatt ttggaatacg gagaatgtga cagtctacga ttctgtgctg gacggagaat
    10681 atctgggatg gcattctaaa aacttacgtt tggtgaactg caaaatttcg ggtacacaac
    10741 cgctttgcta cgcacacgac ctgataatgg aaaattgcac gatggcggat gatgcagacc
    10801 ttgctttcga acacagtagt gtgaaggcaa cgattaaagg cccggttcac agcgtgaaga
    10861 atccccgtac gggaaacatt gttgccgaaa gtttcgggac aatcatcttg gacgagaacc
    10921 tcaaagctcc gggaaactgc gaattgaaac tttgggacgg actgacttgt tttgattgaa
    10981 atatatgaag tacaacttcg atgaaattgt tccgcgcaga ggtacaaatt cctataaatg
    11041 ggattctgcc ggagatgcgg atgtattacc aatgtgggta gctgatatgg atttccgtac
    11101 agctccctct gtggtggaag cgttgaaaag gcgggtggaa catggtatct tcggatatgt
    11161 gcgtgtgccc gatacttact atgaggcgat aacaggatgg tttgccggac gtcatggctg
    11221 gcagattgaa aaagaatgga ttatttatac gactggagta gtaccggccc tgtcagctgt
    11281 catcaaggcg ctgacaactc ccggagataa agtaatcgtg cagacacctg tctataactg
    11341 ctttttctcc tccatccgca ataacggatg cgaggttgcc gccaatccat tgatttacac
    11401 agacggaact tatcagatgg actttattga tttggaacga aaggcggctg acccgagtgt
    11461 aaaagtcctg ctattatgca atccgcacaa tcctgccgga agagtctgga caaagcagga
    11521 actgactcgc ttgggggaaa tctgccttcg gaataatgta tgggtagtag cagacgagat
    11581 tcattgcgaa cttgtctttc cgggacatac ttatatccct tttgcatctg tctcagaaga
    11641 gtttctgatg cattccgtta cttgcacctc gcctagtaaa gcctttaatc tggcggggct
    11701 tcagatgacg gggaagaatg gctggaagaa cttaaccaat acctgtttgc caactaccat
    11761 tgtttaaggg cttactttga taaatatctt cccgaatttc cggtgatgcc attggaaggc
    11821 acctacttgg tatgggtaga ttgctcgact ttgaaacaat cgtcggagga tatagtgaaa
    11881 actctgctgg agaaggaaaa actttgggtg aacgaaggca atctgtatgg agaagctggt
    11941 gaaggattcg tccgcatcaa tatcgcttgt ccgcggcaac ggctgataga aggactgaac
    12001 agaatgaggc gggcgttatc atcgcctatt acctcattca cctaaccaag atagcgtttc
    12061 agggttgcag acgaaattta ttgggagtca tcccgacaat ccgtttgaac atccgactaa
    12121 ggtgctgtgg atactggaat ccgatttcgt aagcaatctg gctggtggtc ttgtccgtag
    12181 acaacagctg ctccttcact aatccgatca ttttatcctg aatatattca gagacggttt
    12241 taccggtctg tttacgtacc atgtcactga aatagttagc ggaaaggaat actttatcag
    12301 cgaagtactt gaccgatggc aacccttgtt tttgcggggc atctccttcg aaatattcgt
    12361 tgagcagatg ttcgaagcgg acaatgatgt ctttatttac tccgtttcgt gtgtcgaact
    12421 ggcgttcgta aaagcgcata cagtagtcga gcagcaatcc tatgttggcg cagatcagtc
    12481 ggcggctgtg tttgtcgatg gaatgttcca gttcgatggt gattttttgc aggcagtcca
    12541 tcactgtttg ccgctcttct tcggaaatat ggagtgcttc gttgatttcg taggagaaga
    12601 aggagtattt ctttatttct tgtccgagcg cagtgccacg tataaggtcg ggatgaaaaa
    12661 gaataccatg cgcgttgggc tgaatatttg gcagcatttc caggtcagtg atttgtccgg
    12721 gagcaaaaca gacgatagtt ccgtcttggt agtcgtaata ttggcgtcca tatttaatat
    12781 caccacattt tacatttttc aagtatagtg catacacttc gtaacgaaac cacgcacgtg
    12841 tgggccacgt agtggatttg gccagatcga tgatgctgac taacggatgt ctggtttcaa
    12901 gcccgaagat ttcgttgtaa cggtcaacgc tgtctattac aatcatttct ttagtattct
    12961 cttccatatc acaatctggt ttttttaatg cgttacaaat ataattcttt tctctttaaa
    13021 atttttactc tcccatcaaa atccatgatt ggggtataaa tatccgtaaa tcgtctacat
    13081 ccgggctgga ccatacctcg taactttgta accggtaatt taacattgaa aagagatagt
    13141 aatatgaaaa agattctatt aattccattg atgatgctga cgatgatgcc gatggcggct
    13201 tgcgacggct caaacgctga tccgattctt ccggagcagc cgggacaacc gggaaattcc
    13261 gacggtggag acgaggatga ttctacagac ccgacaaacc ccattccggg tggtaacggg
    13321 cgatatctgg tactttactg ttcgcgtacc ggtagcacgg agcgtatggc gcaacagatt
    13381 cagcaaacac tcgattgcga tatcctggaa gtggaaccgc aaacacctta tgaaagcgat
    13441 tataatggga tgctcaaccg tgcacaggaa gaactggctg ctatccgtca ggggaattat
    13501 ccggcaatta aaacttcggt tgaagatttt ggcaactatg atatcgtgtt tgtcggctat
    13561 ccgatttggt acggtagcat ggccacaccg atgcagacat tcctgcataa tcatgcttcg
    13621 aaacttgcag gtaagcgtat cgctcttttt gccagcagtg gcagcagcgg catctctgca
    13681 tcagttgacg aggcgcggac gctttgctcc ggtgctactt tcactgaaac actgcttctg
    13741 acttcttcga cgctttcgca gatgggaaac cggatacgga catggctcga aacactcggt
    13801 gcgagtcggg aaaacaatta tccgtctact tctatgaatg tgaagattac agtcggtaac
    13861 cgtaccatta ctgctacgat ggaagacaat gccgcagcgc aggactttct ttcgcgtctg
    13921 ccgcttgaag tgatgctgaa tgattataat aatatcacag agaaaatttt ctatccgtcg
    13981 cctgcactga cgacggcagg agtgacccgt ggctgtgcgc ctgtccccgg tgatattaca
    14041 atctatgtgc cgtggaataa tgtggcgatc ttctgtaaaa gcgggtcgca aagcaatgac
    14101 ttgataaaga ttgggcgcat tgacggtgat ggaatagatg cattgaacgt tccgggcaat
    14161 gtggcagtga aattcgaacg acaatcatga ttgatgctac gccactcatt cccggactga
    14221 agatgaagta aatgacaggc agtactataa atccgtaatt ttggttttta tatccgtaat
    14281 ttgtattata aagagttgga tcagaacagc taattttgca ttatcggcga gttcttaaat
    14341 agtaaaccat agacgtcaca gtatgagaga attatatttt atttttgtaa cagtcatcgg
    14401 atttctgcaa atcccgatgc aatctataaa tgcacagagt atgaaa
//
