LOCUS       c00186_gnlPro..        14928 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ACLJJELL_186.
ACCESSION   c00186_gnlPro..
VERSION     c00186_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 15:26:55
            Original ID  :: gnl|Prokka|ACLJJELL_186
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 26871
            Orig. end    :: 41799
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14928
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[36871:41050]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14179
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14928
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14928
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             242..1351
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_16"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1.4e-09,
                     bitscore: 28.6, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMMKRELHTFIIGSVLFFTACGDKQESEQKSGYRIQGDTVYIADP
                     LLLEKIKVSVSELKPYSKKVITSGVVRPIPPRYAYVAPPFAGRVTKSYVRIGQSVRQGT
                     PLFEISSPDFTSAQKEYFQALSSRELAKKDLKRKEDLIRNGVSSQRELEEAQNALLIAD
                     KEFENASAALRVYQVDNPAEMILGQPMIVRSPIPGEVIKDNIVTGQYLKDDTEPIAIVA
                     DLSKVWIAAQVKEKDIRFINEGSSLDIEISALPGTVIKGNVYHVEEEVDEETRSIQVLS
                     VCDNLNGHLKLGMYTTVHFLSVPVGQIQIPEKALLQGEKDSYVFVQIAPLVFVRTSVTV
                     ETTENGIAVISEGLRPGDKIISEGGYYLK"
     CDS             1358..4465
                     /locus_tag="ctg186_17"
                     /transl_table=11
                     /translation="MKKELMLSIIQKRWVMLCLFVMMCIFGYYSWKQLSIEAYPDIADV
                     TSQVVTQVPGLAAEEVEQQITIPLERAINGLPGMHVMRSKSTFGLSMITIVFKDGTEDY
                     WSRQRVQERLNEVELPYGAVPGLDPLTSPVGEVYRYIIESDQHSLRELTDLQNWVIIPR
                     IKEVSGVADVTNFGGITTQFQVEVDPSKLEQYNLSLSQVVEAIENNNANVGGSVLNRGD
                     LGYVVRGIGLIGNLDDLGHIVVSTTSGVPVFLNDIGSLKYGNLERKGVLGYTDRTRNYS
                     ESLEGIVLLLKHENPSKVLEDIHVAVDELNNETLPEGVRIHTFLDRTNLVDTTLSTVSH
                     TLLMGMALVVLVLILFLGNWRGALLVSITIPVSLLIAFILMHLTDIPANLLSLGAIDFG
                     IIVDGAIVMLETILKKREDNPKQYLEEKSMAQRAKEVGRPILFSTIVIITAYLPLFAFE
                     RVERKLFTPMAFTMSYAMIGALLVALLLIPGLAYAIYRKPHKIYKNKWLDRLKDKYIRT
                     ITRFLEAPLKAIIPSGLILTAGIVLSVVVGKDFLPELDEGSIWLQVNLPPGISVEKSRE
                     LSDTLRARTMKYSEVTYIMVQAGRNDDGTDPFTPSHFEVSIGIKPYDEWPKGKTKKDLI
                     HELEEEYKLLPGFKVGFSQPMIDGVMDKIAGAHSELVVKVYGEDFRETRRIAEEITRAL
                     GTVRGAVDLDIDQEPPLPQLQISMNRDAIARYGLNVSDVADLIEVAVGGKAIAQLYQGD
                     RQYGITCKYKEEARNTPEKIAGLMLTSSTGAKIPLSQVADVRLSVGESTITREMNRRHL
                     TVKLNLRGRDLTSFLNEAQNTINEKVHYDKNKYTIKWGGAFENQKRAYTRLAVIIPLTL
                     TGMFILLYVTFGKFRQAGLVLAIVPLALFGGMLALNVRGMTLNVSSAVGFIAMFGLSIQ
                     NGIIMVSQVNGLRRGGMELRKSVIEGARQRFRPILMTSVTTILGLFPASLATGIGSDVQ
                     RPLATVIVYGLMFSTLISMFLLPVFYYLVENNVLNKKKNDEKEYTI"
     CDS             4443..5693
                     /locus_tag="ctg186_18"
                     /transl_table=11
                     /translation="MKKNIRYNIVLLLLMVEAVLIPAFAQMPEIKLGQSISFEEYLNRV
                     AKKNLSYLAEKLNVSIADAEVIARKIFPDPELEFEAGNETFSLGVSYSLEMGNKRGARI
                     KLARTQAELEKLFLQQGFQDLRAEAADLFLEAILQRELLEVQKSSYEYMYQLSQSDSLR
                     YVSGEITENDVRQSKLETVTLLNTVYSQEAAYHSALVLLNKHMGMSADTLHIPLGNWEE
                     LSRDFALSDLVKAGLDNRIDLLVAQKSTEVTTREYKLTRAERRPDIGVSVSYERNWNGF
                     LPPSRSATAGVSVPLTFSNINKGAVKAAKFRIAQSEIMERDMELQIQAEITQAWFNYEA
                     EKKKIAQYKAGVLEDSQKVLDGMVYKYKRGETSILDVLVAQRTYNEVQQEYLETMKGYA
                     ASLVALESACGIWDICF"
     CDS             6029..6796
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_19"
                     /sec_met_domain="Acetyltransf_1 (E-value: 7e-09, bitscore:
                     26.8, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAKYITLTKENIEKEHICCAFSDKKCKDSYELKKTWLKNEFENG
                     YVFRRLDERAKAFIEYGPAEKAWVPVNAPNYLMINCFWVSGKYKGCGHGKALLQSAVED
                     AKAQGRDGLVTVVGTSKFHFMGDAKWLLRQGFETIEKLPYGFSLLALKINSAAPDPSFN
                     GTVSSGECEEKEGVVVYYTHRCPFAEFHVRNSLVSVTENKGIPLKIVRLETMAQAQNAP
                     TPATIFSLFYKGKFVTTDLSACMEQRFDKALGL"
     CDS             7175..8944
                     /locus_tag="ctg186_20"
                     /transl_table=11
                     /translation="MKSIRSVICFCLFLFVFNQLLFADKTIENDSLYTSEYISRIYMAE
                     PERALSLLDGAESKKTIPLRIIHELRSRVYRNMYMTKLAFLYAKKSYLLDSVSQKDPKH
                     LLTMTVDLAELAVLMSDHKESMRYALDGIKLAQKEKDKGAESKLLFCIGENKWQLSFKE
                     EAYDYFDKAIKLLQGTSSKLEMAMLSYFYGMKMDYLLNDSRSKEALEVGLKREKLLKDI
                     AKLPEKTKGFLDLQYTYLYAKMSYICYLEGKYDQAEKYYQQYLSTENSQTPDGKTYAIP
                     YLLVSKQYQKVVDQCQDFKKLMQEQDTVNLQYISILQKEVKAYKGLKDFEKVAALRESI
                     ISIIDGINSKDKQNAALELNAIHKADEQEEYIAEQTLQLRIRNISLAFLGCVTCLILFV
                     LWRIWRHTIIVKYKNKMLAKFINEKLAGKVENKQLFIDGDAEDPIAVPLDLEPETGFSE
                     KDDLSPDEVVESREEEDENKKIFKELNRIVVQDQLYLSPELSREDLAQIVHLNNARFAR
                     MIKENTGTNFNGYINELRINYAIQLLKQHPNYTIRAIADEAGFNSTPILYSMFKKKTGM
                     TPYEFKKAQESLG"
     CDS             9015..9377
                     /locus_tag="ctg186_21"
                     /transl_table=11
                     /translation="MVQVRIKRVYEDFSETDGYRVLVDKLWPRGIKKEWLKYDYWAKDI
                     TPSAALRRWFHEDIPGHWNDFVVMYQKELEASQAVADFLTLIKPHLVITLLYASKEPVY
                     NHARILRDYLEMHLKE"
     CDS             9462..9998
                     /locus_tag="ctg186_22"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKSLELGNYGGYILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNN
                     FALFTYHDDTIITDTPENEHIQNEARLNNLKVIKEEEFSVAIDFAPCKCMLVSDDEEAL
                     VSLEGHWKRRLNGAL"
     CDS             10001..10555
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_23"
                     /sec_met_domain="HBT (E-value: 1e-17, bitscore: 55.2,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQLAGLGVAMGHSQDSVKVCADYVTASNEEDGVALAVEKAIIAE
                     VRAAEIPLDQLNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLA
                     LGETVAGLGSMILCQPDEIVVGMQVSGNHISSAHEGDTVRAVATIVHKGRSSHVWNVDV
                     FTSTNKLVSSIRVVNSVMKKR"
     CDS             10552..11664
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_24"
                     /sec_met_domain="Chorismate_bind (E-value: 7.1e-58,
                     bitscore: 186.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDEKSNLTTIDALIQRKQPFAVYRVPGEKYPRLLTEDVGAVRLI
                     FDLKELNGQRGFVIAPFRVDKSCPIVLIQSDRTGQPLPMEIVAEEEQGLQSYPEESFHT
                     LCTGKYATCFHTFIEALRDATFDKLVLSRSLTIGKNPEFSPSAVFRAACQRYIHSYIYL
                     CYTPQTGVWLGSTPEIILSGEKNEWNTVALAGTQPLQNGKLPQVWDDKNRQEQDYVASY
                     IRRQLLSLGIRSTESGPYPAYAGALSHLKTDFHFSLKDNKNLGDLLKVLHPTPAVCGLP
                     KEEAYRFILENEGYDRKYYSGFIGWLDPEGRTDLYVNLRCMHIEDEQLTLYAGGGLLAS
                     SELNDEWQETEKKLQTMRRILVSAPIMMNH"
     CDS             11684..13351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_25"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.5e-08, bitscore:
                     23.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLEAHGITKVVLCPGSRNAPIVHTLSTHPGFT
                     CYAMTDERSAGYFAIGLALNGGHPAAVCCTSGTALLNLHPAVAEAYYQNIPLVVISADR
                     PAAWIGQMAGQTLPQPGVFQTLVKKSVNLPEIQTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINIPISEPLFQFTVESLPEVRVITRYQGLNVYDRDYNDLIERLNRYQKRMIIVGQMN
                     LIYLFEKRHTKLLYKHFVWLTEHIGNQTVPGIPVKNFDAALYAMPEEKTGQMTPELLIT
                     YGGHVVSKRLKKYLRQHPPKEHWHVSADGEVVDLYGSLTTVIEMDPFEFLEKIAPLLDN
                     RVPEYPRVWENYCKIIPEPEFGYSEMSAIGALIKALPESCALHLANSSVIRYAQLYQVP
                     STIEVCCNRGTSGIEGSLSTAVGYAAGSDKLNFIAIGDLSFFYDMNALWNINVRPNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKYITAVHKTSAKGWAEERGFLYQRVENEEQLAEAM
                     KTFTQPEAMEQPVLMEVFSNKNKDARILKDYYHQLKQK"
     CDS             13355..14179
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg186_26"
                     /sec_met_domain="ECH_1 (E-value: 4.7e-82, bitscore: 265.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYEDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKKYPKFP"
     CDS             14183..14926
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg186_27"
                     /sec_met_domain="MR_MLE_C (E-value: 6.6e-24, bitscore:
                     75.5, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRVLHFKQPAGTSRGTYTTRKVWYLHFTAPEFPNWVG
                     IGECAPLPNLSCDDLPDYEEVLAKICRQVENQGGKLDMEALCKYPSILFGLETAIRHFF
                     EGSWALWDTPFSRGEAGIPINGLIWMGDFNRMLAQIEKKMEAGFRCIKLKIGAINFEEE
                     LALLQHIRSHYSFKEIELRVDANGAFSPTDAMEKLKRLSELDLHSIEQPIRAGQWEEMA
                     RLTSESPLPIALDEELIGYNTWEEKQ"
ORIGIN
        1 ataagaactt ttcggcttac gataaaaata ccggaatatc atccgttgaa gggttggctt
       61 tttagtcaac cccttatttg tgcgtactct ctaacaacaa agctgctgtt ttaagaagaa
      121 atctttattt actctaataa gattctaata ggattctaac tattctctaa caggctctcc
      181 gaagggagcc gtctatcttt gtacccggaa atccggttac taacttaact tatgtttaat
      241 tatgatgatg aagagagagt tacacacatt tattattggc agtgtgttgt tttttaccgc
      301 atgcggggat aaacaggaat cagagcaaaa aagtggctat cgtatacaag gtgacacggt
      361 ctatattgca gatcctcttt tacttgaaaa gatcaaagta tcagtgtctg aactgaaacc
      421 ctattccaag aaggtgataa cgtccggtgt ggtgcgtccc attcctcccc gttatgctta
      481 tgttgctcct ccatttgcag ggagagtcac aaaatcttat gtgcgtatcg gacagtcggt
      541 acgtcaggga acacctttat ttgaaatcag ttcccccgac tttacttctg cacaaaagga
      601 atactttcag gcactttcgt ccagggaact tgctaaaaaa gatttgaaac gcaaagaaga
      661 tctgataagg aatggtgtca gttcgcaaag agaactggaa gaagcccaga atgctttatt
      721 gatagcagat aaggagtttg aaaacgcctc tgccgcattg cgggtatatc aggtggacaa
      781 tccggcggaa atgatattgg ggcaaccgat gattgttcgt tctcctattc ccggggaagt
      841 gataaaggat aacatcgtaa cagggcaata tctgaaagac gataccgaac cgatagctat
      901 tgttgccgac ctgtctaagg tatggattgc ggctcaggta aaggagaaag atatccggtt
      961 tataaatgaa ggcagtagtc tggatattga aatttcggca ttgcccggta cggttattaa
     1021 aggcaatgtg tatcatgtag aggaggaggt agacgaggaa acccggtcca ttcaggtact
     1081 ttcggtctgt gataatttga acggacatct gaagctgggg atgtacacta ctgtccactt
     1141 tctgagtgtt ccggtcggac aaattcaaat cccggagaaa gcgttactgc agggcgaaaa
     1201 ggatagctat gtatttgtgc agattgctcc gttggttttc gtacggacgt cggtgacagt
     1261 ggagacaaca gaaaacggaa tagcggtgat cagcgaagga ttgcgtcccg gagataagat
     1321 aatcagtgaa ggaggatatt atttaaagta agaaattatg aagaaggaat taatgctttc
     1381 aattatacaa aaaagatggg taatgctttg cctgtttgtg atgatgtgta tctttggata
     1441 ttactcatgg aaacagcttt cgatagaagc atatccggat attgcagatg tcacttccca
     1501 ggtggtcact caagttcccg gactggctgc ggaggaagtg gaacagcaga taaccattcc
     1561 tttggaacgc gctattaatg ggctgcccgg tatgcacgtc atgcggagta agagtacatt
     1621 cgggctgtca atgattacca ttgtctttaa ggacgggaca gaggactact ggagccgcca
     1681 gcgcgtacag gaaagattga atgaagtaga actgccttat ggagctgttc cgggacttga
     1741 tccgctgaca tctcccgtag gagaagtgta ccgttatatc atagaaagtg accagcactc
     1801 attacgcgaa ttaaccgacc ttcagaactg ggtaattatt ccccgtatca aggaagtgtc
     1861 gggagtggct gatgtaacca atttcggtgg gatcactact cagttccagg ttgaagtaga
     1921 tccgtccaaa ctggaacaat ataatttatc tctcagccag gttgttgaag ccattgagaa
     1981 taacaatgcc aatgtggggg gaagcgtgtt gaatcgtggt gacttgggtt atgtggtacg
     2041 gggaattgga ttaatcggaa atttggacga tttgggacat attgtagtga gtactacttc
     2101 cggagttcct gtctttctga atgatatagg ttctttgaag tatggaaatc ttgaaagaaa
     2161 gggagtgctg ggatatacgg accgtacccg caactactct gagagtctgg aaggaattgt
     2221 actccttctg aaacatgaga atccgtctaa agtactggaa gatattcatg tggcagttga
     2281 tgagttaaat aatgagacat tgccggaagg agtgaggata catacttttc tggatcgtac
     2341 caacttggtg gatactactt tgagtaccgt atcccatacc ttgctgatgg gtatggcttt
     2401 ggtggttctt gtgcttattc tgtttctagg caactggcgt ggtgcattat tggtatctat
     2461 aacgattcct gtgtcattgc ttatcgcttt tattcttatg catctgacgg atattccggc
     2521 taaccttctg tcgcttggtg ctattgattt cggtattatt gtggacggcg ctatcgttat
     2581 gctggaaacg atccttaaga aacgtgagga taatcccaaa caatatctcg aagaaaaaag
     2641 catggcgcaa cgcgccaaag aagtgggtcg gcctattctt ttctcaacca ttgtcattat
     2701 tacggcatac cttccgctgt ttgcctttga acgtgttgaa cgcaaacttt ttactccaat
     2761 ggcatttacg atgagctatg caatgattgg agcactgttg gttgcgctct tattgattcc
     2821 gggacttgcc tatgcaatct atcgtaaacc acataaaata tataagaata aatggctgga
     2881 cagactaaag gataaataca ttcgtaccat tacaagattt ctggaagctc ccttaaaagc
     2941 catcattcca tcaggactga ttctgacagc ggggatcgtg ttgagtgttg tcgtaggaaa
     3001 agacttcctt ccggagctag atgaaggttc gatatggtta caggttaatc tgccacccgg
     3061 aatttccgta gaaaagtcac gggagttatc cgatactttg cgtgcccgta cgatgaagta
     3121 ttccgaagta acttatatta tggtacaggc gggaaggaat gacgacggaa ctgatccgtt
     3181 caccccttca cattttgaag tgtccatcgg tattaagcct tatgatgaat ggccgaaagg
     3241 aaaaactaaa aaggatttga ttcatgaact ggaagaagaa tataagttac ttcccggttt
     3301 taaagtagga tttagccaac ctatgataga cggggtgatg gataagatag ccggggccca
     3361 tagtgaactg gtggtgaaag tatatggcga agattttcgt gaaacacgtc gtattgccga
     3421 agaaataacc agggcattag gaactgtgcg aggggctgtt gatctggata ttgatcagga
     3481 accacccttg ccacagttac agatcagtat gaatcgtgat gccatagccc gttacggatt
     3541 aaatgtatcc gatgtagcgg atctgattga agtggctgtc ggaggtaaag ctatcgcaca
     3601 actttatcag ggtgaccgcc agtatggcat cacctgtaag tataaagagg aagcgcggaa
     3661 tactccggag aaaatagccg gacttatgtt gacttcttcc accggtgcaa agatacctct
     3721 ttctcaggtt gccgatgtca gattgagtgt cggcgaaagt acgattacca gggaaatgaa
     3781 cagacgccat ttgacggtaa agctgaattt gcgcggtcgt gacctgacat cttttctgaa
     3841 tgaagcccag aatacgatca atgagaaagt acattatgac aagaataaat ataccatcaa
     3901 atggggaggg gccttcgaaa atcaaaaacg ggcttataca cgtcttgctg tcattatacc
     3961 gctgacactg acggggatgt ttatactgct ttatgtcacg ttcgggaagt tccggcaggc
     4021 aggactggta ttggctattg ttcctctggc acttttcgga ggtatgcttg ctcttaatgt
     4081 gcgtggtatg acgctgaatg tatcttctgc cgtaggattt atagcgatgt tcgggctttc
     4141 catacagaat ggaattatca tggtatcgca ggtcaatggg ctgcgcaggg gaggaatgga
     4201 actccggaaa tcggtcatag aaggggcacg ccagcgtttc cgacctattc tgatgacttc
     4261 ggtcactacg atactcggac ttttcccggc ttcgttggca actggaatcg gtagtgatgt
     4321 acagcgtccg ctggcaacag tgattgtgta tggattgatg ttttcaaccc ttatttctat
     4381 gtttctgctt ccggttttct attatctggt tgagaacaat gttttaaata aaaagaagaa
     4441 cgatgaaaaa gaatatacga tataatatag tgctcttgct gttaatggtg gaagccgtac
     4501 tcattccggc ttttgcgcaa atgcctgaaa taaagctggg gcagtctatt tctttcgaag
     4561 aatatctgaa tcgggtagcg aaaaagaacc tgagttattt agccgaaaaa ctcaatgtga
     4621 gtattgctga tgcggaagta attgcccgga aaatctttcc ggatccggag ttggaatttg
     4681 aagcaggtaa tgagactttc tcgttgggag tttcctattc attagaaatg ggaaataaaa
     4741 ggggagcacg tattaagttg gcgcggactc aggcagaatt ggagaaactg ttcctgcaac
     4801 agggctttca ggatttgagg gcggaggctg ccgacctttt tctagaagca attcttcagc
     4861 gcgaattact tgaagtacag aaaagttctt atgagtatat gtatcagctg agtcagtcag
     4921 atagtttacg ttatgtttcg ggagagatta cggagaatga tgtccggcag tcaaaactgg
     4981 aaactgtcac cttgcttaat actgtttaca gtcaggaggc ggcttatcat tccgctttgg
     5041 ttttgttgaa taaacacatg gggatgagtg ctgatacgct tcatatccct ttgggaaatt
     5101 gggaagagct aagcagggac tttgctctgt ctgatttggt caaagcggga ctggataatc
     5161 gcatcgacct gcttgttgct caaaaaagta ctgaagttac tacccgggaa tataaactga
     5221 cgagagcgga acgcagaccc gatatcggag tatctgtttc ttatgaaaga aactggaacg
     5281 gctttcttcc tccgtcccgt tctgctactg ccggtgtatc tgttcctctg acattctcga
     5341 atataaataa aggagctgta aaagctgcaa agtttcggat tgcccaatcg gagataatgg
     5401 aaagagatat ggaattgcag atacaggcag agataaccca ggcctggttc aactatgagg
     5461 ctgaaaagaa aaagatagct caatataaag ccggtgtact tgaagactcg cagaaggtgc
     5521 tcgacggaat ggtatataaa tacaaacggg gagaaacgag tattcttgat gtactggttg
     5581 cccagcgtac ttataatgaa gtgcaacagg agtatctgga aacaatgaaa ggatatgccg
     5641 cttcactagt agcattggaa agtgcttgtg gtatatggga tatatgcttt taacagttaa
     5701 atatccggct ttactattgt gaattgcagc aaagccggat atttgtatgg ttaccagtca
     5761 gcggtttcac gctttatgtt aaatcattgt gcgatattcc tcctgttttt tcttagggag
     5821 ttttttgatc acttcttcca cagagtggtc aataagttct ttgataagtt tgtcactcag
     5881 gtttatttac ttatctgttt tccgaacttt aatccgtact actgtgtcat tttgacgaga
     5941 ctggacaatg ttttattact ttcgattgtg tatctttgct gtagttaaaa tggacaaccg
     6001 gaatttatat actaataaac agaatattat ggaagcgaag tatatcactc tgactaaaga
     6061 gaatatcgaa aaagaacata tttgctgtgc tttctccgat aagaaatgca aggatagcta
     6121 tgagttgaaa aagacatggc tgaaaaatga gtttgagaat ggctatgttt tcagacggct
     6181 tgacgaacgt gcaaaagcat ttatagaata tgggcctgcc gaaaaagctt gggttccggt
     6241 taatgcacct aactatttaa tgataaactg tttttgggtt tcaggaaaat ataaaggatg
     6301 cgggcatggc aaagcactat tgcagtctgc tgtcgaggat gccaaagcac agggtaggga
     6361 tggcttggtg actgtggtcg gtacctctaa atttcatttt atgggtgatg cgaaatggtt
     6421 attacgtcag gggtttgaga cgatagaaaa actaccctat ggtttcagtc ttttggcttt
     6481 gaagataaat tcggcagctc ctgatccgtc attcaatgga acagtatcaa gtggagaatg
     6541 tgaggaaaaa gaaggtgtag tcgtttatta tacacatcgt tgtccgtttg cagagtttca
     6601 tgtccgtaat tctttagtga gtgtgactga gaacaaaggt attccattga agatagtcag
     6661 attggaaacg atggcacaag cacaaaatgc acctacacct gctactatct tttccctttt
     6721 ctataaagga aagtttgtaa cgacggattt gagtgcatgt atggagcaac ggtttgataa
     6781 agcgttggga ttataatctt tcttattaca gtatgtgttt ctcttttttg attttctgtt
     6841 tttgtgctgt tttgctctga tgagtgtggc gggttaataa ttgtctggtg tttatttaga
     6901 ctggtcggtt cgatttttca tgtgctgctc tgatcttatg cagattcatt aatagaatcg
     6961 gcagtttatt tatatgttga gatgttttgt tttatgtatg tgacatgtgc ttgattttta
     7021 gtattttatt gtatgtggtt ggtggggaaa acttgatggc tcctgacttt tataatcact
     7081 aacttttctt attttagttc attcaaatat gttcaattct tgcattttat gaaactatgt
     7141 tttacttttg gggagtaaaa tcattgggat tataatgaaa agtattcgct cggttatttg
     7201 tttttgtttg tttttgtttg tgtttaacca gctccttttc gccgacaaaa ctatagagaa
     7261 tgattcgcta tataccagtg agtatataag tcgaatttat atggcagaac ctgaacgggc
     7321 tttaagtttg ttggatggag ctgaaagtaa gaagactatc cctctgcgta ttatacatga
     7381 attacgcagc agggtttatc gtaatatgta tatgactaaa ctggcttttt tgtatgccaa
     7441 aaagtcttat ttgctggatt ccgtttctca gaaagatcct aagcacttgt tgaccatgac
     7501 tgtcgacctg gcagaattag cagtgcttat gagtgaccat aaagagagta tgaggtatgc
     7561 tcttgatggt atcaagctag cacaaaaaga aaaggataaa ggggctgaaa gtaagctgtt
     7621 gttttgcatt ggtgaaaata aatggcaatt gtctttcaaa gaggaggcat atgactattt
     7681 tgacaaagct atcaaattgc ttcaaggtac aagttccaaa ttggaaatgg ctatgctttc
     7741 atacttttat gggatgaaaa tggattatct gctcaatgat tcccgtagta aagaagcatt
     7801 ggaggttggg ttgaagcgcg aaaagctact taaagatata gctaaattac cggaaaaaac
     7861 aaaaggcttt cttgatctgc aatatactta cttgtatgca aaaatgtcgt atatctgcta
     7921 tctggaagga aagtatgatc aggcggaaaa atattatcaa caatatttgt caacagagaa
     7981 ttcacagaca ccggatggaa aaacctatgc gataccttat ctgctagtgt ctaaacaata
     8041 tcagaaagtc gttgatcaat gtcaggattt taagaaattg atgcaagagc aggatactgt
     8101 caacttgcag tatattagta tccttcagaa agaggtgaaa gcttataaag gcttgaagga
     8161 ttttgaaaaa gtagcagcat tacgtgagtc tattatttct attattgatg gtattaacag
     8221 caaggataaa cagaatgcgg ctttggaatt aaatgctatt cataaagctg acgagcagga
     8281 agaatatatt gccgaacaga ctttacagtt aagaatcaga aacatatcac ttgctttttt
     8341 gggatgtgtc acttgtctca ttttatttgt gctatggcgg atttggcgtc atacgattat
     8401 tgttaaatat aaaaacaaaa tgctggcaaa gtttatcaat gagaaactgg ctggaaaagt
     8461 agagaacaaa caattattca tagatggaga tgcggaagat ccgatagctg ttccattgga
     8521 cttggaaccg gaaactggct tttccgaaaa agacgattta tctccggatg aagtagtgga
     8581 gagtagggag gaagaggatg agaataagaa aattttcaaa gaactgaatc gtattgttgt
     8641 tcaggatcag ttatatctgt ctccggaatt gtcgagagag gatctggctc agattgtaca
     8701 tttgaataat gcgcgtttcg cccggatgat caaggaaaac accggaacta atttcaacgg
     8761 gtatattaat gaacttcgta ttaactatgc gattcagtta ttgaagcaac atcccaatta
     8821 taccattcgt gcgatagctg atgaagccgg atttaatagt acgcctattc tgtacagtat
     8881 gttcaagaaa aagactggta tgactcctta cgaatttaaa aaagcgcagg aatccttagg
     8941 ttgattttgg ctttttcgat aaacaatttt ccgttttatc ggtttattct tatgataact
     9001 aaatataaac ggaaatggtg caagttagga taaagcgagt gtacgaagac ttttcagaga
     9061 ccgacggata tcgggtgctg gtagataaac tctggccacg tggaatcaaa aaagaatggt
     9121 tgaaatatga ttactgggca aaagatataa cgccttccgc agcactgcgc agatggtttc
     9181 atgaagatat tccggggcac tggaatgatt ttgtcgtaat gtatcagaag gaactggaag
     9241 cttctcaagc tgttgccgat tttctgactc ttatcaaacc tcatctggtg atcactttgc
     9301 tttatgcatc caaagaaccg gtttataatc atgcccgaat ccttcgtgat tatttggaaa
     9361 tgcatctgaa agagtgaaat taaagtaatt tttatctctt tccgctttca gtcgttcact
     9421 caatttccta cctttgtaat ctaaatcaaa atcgtgtgtc catgaagtat aaattattag
     9481 ttcttgatgt agacggaacg cttctcaatg atgcaaaaga aattagtaaa cgtacattgg
     9541 ctgctttgct gaaagttcag cagatgggag tacgtatcgt gttggcatcc ggccgaccga
     9601 cttacggtct gatgccttta gccaaatccc tagaactcgg aaattatgga ggttatatcc
     9661 tttcttataa tggttgccag ataattaatg ctcaaaacgg agaaatactg tttgagcgga
     9721 ggattaatcc ggaaatgttg ccttatctgg aaaagaaggc aagaaaaaat aatttcgcac
     9781 tgttcactta ccatgatgat acgatcatta ctgacactcc ggagaatgaa catatccaga
     9841 atgaagctcg cttgaataat ttgaaagtga tcaaggaaga ggaattttct gtagcaattg
     9901 actttgctcc gtgtaagtgt atgcttgtca gcgatgacga ggaagcgttg gttagtctgg
     9961 aaggacactg gaagagacgg ttgaacggag ctttgtaacg atgattcagc tggcaggact
    10021 gggagtggcg atggggcatt cgcaggattc ggtaaaggtc tgtgcggatt atgtgacagc
    10081 ttccaatgag gaagacggag tggctctggc tgtcgaaaag gcgataatag cggaagttcg
    10141 cgctgcagag attcctttgg accagttgaa tgcacaggcg cgtcacgcat tgatgggtaa
    10201 tctgggtatc caatatacat atgccgacga agaccgtgta gaggcgacga tgccggtaga
    10261 tcaccgtacc cgtcagccgt tcggtatttt gcacggtgga gctacgcttg cattgggaga
    10321 aacagttgcc ggactcggct cgatgattct ctgtcagccg gatgaaattg tggtaggaat
    10381 gcaggtcagc ggaaatcata tatcttctgc gcacgaaggt gatacagtac gtgcagtagc
    10441 gacgattgta cacaaaggac gttcctccca tgtatggaat gtggacgttt ttacttcaac
    10501 caataaactg gtgtcctcta tacgggtggt caacagtgtg atgaaaaaaa gatgattgac
    10561 gaaaaaagta acttgacaac tattgatgca cttattcagc ggaaacagcc ctttgctgtt
    10621 tatcgtgttc ccggggagaa gtatcctcgt ctgttgacag aagatgtcgg agctgtccgc
    10681 ctgattttcg atttgaaaga actgaatgga caaagaggat ttgtgattgc tccgttccgt
    10741 gtagataagt catgtccgat tgtgttgata cagtccgaca ggactggaca accgttgcct
    10801 atggaaatcg tggcagagga agagcagggc ttgcaaagtt atccggagga atcttttcat
    10861 accctttgta ctgggaagta tgcgacctgt tttcatacat ttattgaagc cttgcgtgat
    10921 gctacctttg ataaactggt gctttcccgt agtctcacta ttggaaagaa tccggagttt
    10981 tccccttcag ctgtttttcg tgcagcttgt caacgttata ttcattccta tatctatctg
    11041 tgttatactc ctcagacggg cgtgtggctg ggaagtactc ccgaaattat attgtcgggc
    11101 gaaaaaaatg aatggaacac agttgccctg gcaggaactc aacctttgca gaatggtaaa
    11161 cttccgcaag tatgggatga caaaaaccgt caggagcagg attatgtggc gtcctatatc
    11221 cgtcggcagc ttctttcgct gggcattcgc tccacagaga gcggacctta tccggcttat
    11281 gccggtgcct tgtcacatct gaaaactgat ttccatttct ctttgaaaga taataaaaat
    11341 ctgggagacc ttctgaaagt cctgcatccg actcctgccg tgtgcggact gcctaaagaa
    11401 gaagcctacc ggttcatttt ggaaaatgaa gggtacgatc gtaagtatta ttccggtttt
    11461 atcggttggc tcgatccgga gggacgcaca gatttgtatg tgaatctgcg ttgcatgcac
    11521 attgaagacg agcaattgac actgtatgcc ggtggcggat tgttagcctc ttcagagttg
    11581 aatgatgaat ggcaggaaac ggaaaagaaa ttgcagacca tgaggcgtat tcttgtatct
    11641 gctccaataa tgatgaatca ctaacaagct aatcactatc aatatgtatt cggacaagaa
    11701 aaatatactc cagttggtcg cgctgcttga ggcgcatgga attacgaaag tagtgttatg
    11761 tcccggtagc cgtaatgcac ctattgtgca tacgctgtct actcatccgg gttttacttg
    11821 ttatgctatg acggatgaac ggagtgccgg ttattttgcg attggtcttg cgctgaatgg
    11881 cgggcatcct gctgccgttt gctgtacttc cggtacagcg ttgctcaatc ttcatcctgc
    11941 tgtggcagaa gcgtattatc agaatatacc tttagttgtt atctctgccg atcggcctgc
    12001 tgcctggatt ggacagatgg cgggacagac attgccgcag cccggtgttt ttcagacatt
    12061 ggtcaagaag tcggtaaacc ttccggagat tcagacagaa gaggatgaat ggtactgtaa
    12121 ccgcttggtg aatgaagcct tgctggaaac caaccatcat ggaaaaggtc cggtacatat
    12181 taatattcct atatccgaac ctttgttcca gtttacggtg gagtcgcttc ccgaagtacg
    12241 tgtcatcacg cgctatcagg ggctgaatgt atacgaccgg gattacaatg acctgatcga
    12301 acgcttgaac agatatcaga agcggatgat tattgtcgga cagatgaact tgatttactt
    12361 gtttgagaaa cggcatacca aattgttata taaacatttc gtgtggctga ccgagcatat
    12421 cggtaatcag acagtacccg gtattccagt gaagaatttt gatgcggcgc tttatgcgat
    12481 gcccgaagag aaaaccggcc agatgactcc cgagttattg attacttatg gcggacatgt
    12541 ggtttccaag cggttgaaaa aatatcttcg gcagcatccg cctaaagaac actggcatgt
    12601 gtctgctgat ggagaagtgg ttgaccttta cggttctctg actaccgtca tcgaaatgga
    12661 cccgtttgag tttctggaga aaatagctcc attgctggat aaccgcgtgc cggagtatcc
    12721 ccgtgtatgg gagaattatt gcaagatcat tcccgaaccg gagttcggat attcggaaat
    12781 gtcggctatc ggtgctttga taaaagcatt gccggaatca tgtgcattgc atctggcaaa
    12841 tagttctgtt atccgctatg ctcagttata ccaggttcct tctacgattg aggtatgctg
    12901 taatcggggt acaagcggca tcgaaggctc gttgtccacg gcagtgggat atgctgccgg
    12961 ttcggataaa ctaaatttta tagctatagg tgaccttagt ttcttttatg atatgaatgc
    13021 tttgtggaat atcaatgtcc gtcctaatct acgcattctt ttgctgaata acggaggagg
    13081 ggagattttc catacattac ccggactgga tatgtcgggt acatcgcaca agtatattac
    13141 agccgttcac aagacatctg ccaaaggatg ggcggaagaa cgcggattcc tttatcaacg
    13201 ggtagagaat gaagaacagc ttgccgaagc gatgaaaacc ttcacacaac cggaagccat
    13261 ggaacaaccg gttctgatgg aagtattcag caataaaaat aaagatgcac gtatactgaa
    13321 agattattat catcaactaa aacaaaaata gattatgtca acacaaagag aatggacaac
    13381 catcagagaa tacgaagata tcctctttga ttactataat gggattgccc gcatcaccat
    13441 taaccgtgaa cgctatcgaa atgcatttac tccgactaca acggctgaaa tgagtgacgc
    13501 attgcgcatt tgccgggaag aagcggatat tgatgtgatc gtgattacgg gagctggtga
    13561 caaggctttc tgttcgggcg gtgaccagaa tgtgaaaggg cgtggcggct atatcggcaa
    13621 ggacggtgtt ccccgtctga gtgttctgga tgtacagaaa caaatccgca gcattccgaa
    13681 accggtaatt gctgccgtaa atggatttgc cattggtggc ggacacgtgc ttcatgtagt
    13741 ttgcgattta tcgattgctt cggagaatgc gatcttcgga cagaccggtc ctcgcgtagg
    13801 tagctttgat gcaggtttcg gagcctctta tctggctcgt gtcgtcggtc agaagaaggc
    13861 acgtgagata tggttccttt gccggaaata caatgcgcag gaagcgttgg atatgggatt
    13921 ggtgaataaa gtagttccat tggagcaact ggaggatgag tatgtgcaat gggcggaaga
    13981 aatgatgctg ctcagtccgt tggccttgcg gatgattaaa gccggattga atgccgaact
    14041 ggacggccag gcaggtattc aggagctggc aggggatgcg accttgcttt actatctgac
    14101 ggatgaggct caggaaggaa agaatgcatt tctggagaaa cgtaaaccta actttaagaa
    14161 atatccgaag ttcccttaaa caatggattg caaaatagac attattccgc gggtgcttca
    14221 tttcaagcag ccggccggaa cttcacgagg cacatacaca acgcgaaaag tctggtatct
    14281 tcattttact gctcccgaat ttcccaattg ggtagggatc ggggagtgcg ctcctctgcc
    14341 aaatcttagc tgtgatgatc ttcccgatta cgaggaagtg ctggctaaaa tctgccggca
    14401 ggtagagaat cagggaggta agctggacat ggaagctcta tgcaagtacc cttccatcct
    14461 ttttggcttg gagacagcca ttcgtcactt ttttgaagga agctgggctt tgtgggatac
    14521 acccttctca cgtggggaag caggtattcc gataaacggg cttatctgga tgggtgactt
    14581 caatagaatg cttgctcaga tagagaagaa gatggaggcg ggattccgct gtataaagtt
    14641 gaagatcggt gccatcaact ttgaagaaga actggcttta ctccaacata tccgctctca
    14701 ctattctttt aaagaaatag aattgcgtgt agatgccaac ggagcattct cgccaacaga
    14761 tgcgatggag aaattgaaac gcttgtccga actggactta cattcgatag aacagcccat
    14821 tcgtgccgga caatgggaag aaatggcacg tcttacttcc gaatctcctt tgccgatagc
    14881 tttggatgag gaactgatag gctataatac ctgggaagaa aagcaaag
//
