LOCUS       gnlProkkaPBPAGIDJ_66   13670 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PBPAGIDJ_66.
ACCESSION   gnlProkkaPBPAGIDJ_66
VERSION     gnlProkkaPBPAGIDJ_66
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:36:06
            Original ID  :: gnl|Prokka|PBPAGIDJ_66
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 47494
            Orig. end    :: 61164
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13670
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13670
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13670
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2419..3453
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg66_37"
                     /sec_met_domain="PF04055 (E-value: 4.9e-18, bitscore: 57.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
     CDS             3472..4512
                     /locus_tag="ctg66_38"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGEASKE
                     AEQTNK"
     CDS             4517..5611
                     /locus_tag="ctg66_39"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5621..6862
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg66_40"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6849..7376
                     /locus_tag="ctg66_41"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7382..8341
                     /locus_tag="ctg66_42"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGIPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINRLTRITYPQVRLRRKLKLLLPMHLLQKL
                     RHRLLKLLLLQQSNSLCRQVRLWGKTINGKVQTDAAFL"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg66_43"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_44"
                     /sec_met_domain="PqqD_RRE (E-value: 4.3e-11, bitscore:
                     34.2, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-17, bitscore: 55.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGLIKLVIPVV"
     CDS             complement(10370..10654)
                     /locus_tag="ctg66_45"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10691..11758)
                     /locus_tag="ctg66_46"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSAGKKVAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDDK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11831..13342)
                     /locus_tag="ctg66_47"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPTMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             13524..13670
                     /locus_tag="ctg66_48"
                     /transl_table=11
                     /translation="MQHHYELTFISPEKDFWFFVKFGGTSSIVNKESWLSVVYFLPYCT
                     SAFL"
ORIGIN
        1 aaaactcggt tttgatggga gatgctggct tgaacacttt ttcagggaac acacttcgaa
       61 acctcaagga gattgaagaa gatttgaatt ctattcaaaa gttcagtcag ttgtggagtg
      121 cgctgggtgc atcaagatac cctatcattc tgttgattga tgacattagt tatctgaatc
      181 cgactgaagc atccctgttt tctttatttg catctattcc cccgaacgtg aaagtcgtgt
      241 tgagcttttc ggcgtcatcc actgcctacc tgccctttgt tcagaatggc tacgctcatt
      301 tccagttgaa tggcttttcg caggcggatg ccaagttgtt ctcaaagcaa tatttgtcta
      361 cttactccaa ggctttgtcc gcacaacagg aagatattct tgcttcgtgg gtgctggcta
      421 aacaaccgcg ctgtttaagt gtattgctca acgagctggt ttcgttcggt cagtacgatg
      481 ctctcaatga atatatgagt ggatattgcc ggctcaatga ggttgggcaa ttctatgaca
      541 gtgtgttacg gcgtttgtcg gctgattatg gtttcgaaga gattggaaga acgcttctga
      601 tgctttcact tactttagaa ggatttaccg aagatgaagt gaagagcatg gcagacatta
      661 atcagatact ttggtcgcag ttgagagtgg aaatgagcag ctggctcacc aacaaaggag
      721 gacgatattg cattggtgac acacaaatgg tagaggcaat cgaacgctat ttcgctcaag
      781 atgacgaatg tatagatgat agtcgccatg aaattatttc cgctctgctg gatgaggaag
      841 agatcctttc ccatccgttg acttttgccg attataacta tcgcatgaaa cagttctgct
      901 accatgattc gtatcgctat aaagtggaga ttacctatca atgctataag atgcaagaat
      961 gggatatatt gaaggattgg atttgtgatg tggagatttt cgagattctg tatcgcacga
     1021 atcgttctct gttggaagat agctggaagg cgatcatgaa cgacaatcct gaagttacgc
     1081 ctgaagtcta tgccgaattg gactttgatg agatcgattc ttttttaatt cctgtcattg
     1141 ctaatgatat ggctactttc ttgagcagtt ctttccatct gacgaaggcg gtggctgctg
     1201 tgagtgagaa gagtatggaa ggtgctgcca tgccactcat tgccaagtcg gtattgaaga
     1261 tgaatgaggg atgccgctat gcccgtaatg aagaatacga aacggcatgc gactgtttct
     1321 tgaaagcatt ggtgatgcag gaaaacatag taccgactcc ggaactggag attgccaaca
     1381 cctgccgaaa tctagctctg gcatattact acaatgagca atacaatgaa gcagtgacct
     1441 atttgaatag ggcgcttgat tatcatgcgg cttctgctga cgagaagagt caggcagaag
     1501 tcattgaact ttccgaatat ctggcttatt gtgattacta taaggatgag gaagagagtg
     1561 ctgccgagaa attccggaaa gtagctgaaa tgcacgagtc gttgaatggt aggctgtccg
     1621 gtggagtggc taaatgtttg cgtatgcagg gtaaatgtct ttattatatc aaacgatacg
     1681 atgaagcatg gatgctgatg aatcaggcgt tggacattgc tatacagata gacagcaaaa
     1741 aacagatcgt cgcttgtcat aaacagttgt attatctatg cagggaattc aaacggatga
     1801 tgaatgaacg tggcgatgag caggcgtcta ctttattctt ccgtgagtct cttctgcatg
     1861 aaatgtattt cagcgaaaaa ccgcgtctgg cggaactgac tgtccgctac gaggcattga
     1921 gatgtgatat tatgcagcag tattacatga ataaagacta tgataacgtg attcgtattg
     1981 caacgtcttt ggattttcac gatgatgctg accctaatgc ttcctgtctg gtatattatt
     2041 acaaagcaca ggcttatgtg aagttggaga attatccaat ggcgaaagag gctttcttca
     2101 gagagcttga actgcgaaag aagtatttgg gatgggagga agaagatacg attctggctt
     2161 gtcagaactt aggggttttg cacagctttt gtaatgaacg ggaagaggcg ttggcttgtt
     2221 tccgtgaggc gtacggtcat gaagtgaaaa agaatggcga ggattctgaa atggcgcaaa
     2281 agctacttca atatatcagc gtggttgaat cataacggag gcatacttcc cttttttgtt
     2341 aacttttaca ttcctgctat acggaaatcg actttatttc cttacatttg cagatataaa
     2401 ctatcaacag aaagaagaat gtctaaatat ccccttttag gaatgactct tgtagagctt
     2461 caatcattga caaaaagact gggtatgccc ggctttgctg ccaagcagat tgcatcctgg
     2521 ctttacgaaa agaaggtagc ctcgattgat gatatgacta atttgtcatt gaaacaccgg
     2581 gagttgctca agcagaacta tgaggtggga gcagaagctc cggtagatga aatgcgctct
     2641 gtagatggta cggtgaagta tctttataaa gtgggtgaga accattttgt agagtcggtt
     2701 tatataccgg atgatgaccg ggcaacgttg tgcgtgtcgt cacaagtagg ttgcaagatg
     2761 aactgtaagt tctgtatgac cggtaaacag gggtataccg ctaacctgac cgccagccag
     2821 atcatgaatc agattcattc gctgccggaa cgggacaaac tgactaatgt cgtaatgatg
     2881 ggaatgggcg agccgctcga taacctggat gaggtattga aggcattgga actactgacc
     2941 gctacctacg gttacgcatg gagtccgaag cgtatcacgc tttctactgt cgggctacgg
     3001 aaaggattgc agcgttttat tgaagaaaac gactgccacc ttgccatcag ccttcactct
     3061 ccgctgaccg ttcagcgtgc tgaattaatg ccggcggaaa aggcgttttc aatcaccgaa
     3121 atggtggaac tgttaaaaaa ctatgatttt agtaaacaac gtcgactttc gtttgaatat
     3181 attgttttta aagggctcaa tgattcgcag gtctatgcca aagagttgct gaaacttctt
     3241 cgcgggctgg attgcagggt gaatctgatt cgttttcatg ccataccggg ggtagacctt
     3301 gagggggcgg acatggatac gatgacccgt tttcgtgatt atctgacatc acacggactt
     3361 ttcaccacta tccgttcatc cagaggcgaa gatatttttg ccgcttgcgg tatgctgtcg
     3421 acagcgaaac aggagaaaaa taatgaaagt taatatataa aaccgaacat catgaaaaag
     3481 tactctttta ttttatgcat cgctttggta gcctttgtcg ttgcatcttg tggtctgaaa
     3541 ggaaatcaca cctctagtgg tcgtgcttac gagcttttgg ttgtagtaga tcacggtgtt
     3601 tgggatcgtg ctgccggaag ggctttacat gatgcgctcg atgctgatat gcccggtttg
     3661 ccgcagtcgg aaccttcttt ccggattatg tatacttcac cgaaagatta tgattctacg
     3721 ctgaagttga tacgtaacat tattattgta gatatacagg atatatatac gaaagcctcg
     3781 ttcaaatatg cgaaggacgt gtatgccaat ccgcagatga tattgactat ccaggctccg
     3841 aacgaagaag agttcgagaa gtttgtggaa gagaacaaaa agacgattgt cgacttcttt
     3901 acccgtgcgg aaatgaaccg tcagattacg ttcctggaag ggaaacacag taacttcatt
     3961 tcgcagaaag tggacagttt gttcggatgc gacatctggg tggatgccga actggctaat
     4021 tcaaagaccg gggatgattt cttttgggct tctaccaaca caggtagtgc tgaccgtaac
     4081 tttgtgatgt actcttatcc gtacactgac aaggatacgt ttaccaaaga atattttgtg
     4141 cacaaacgtg actccgtgat gaaagccaat atccccggat tcaaggaagg cgtttatatg
     4201 tcgaccgata gtttgctgac cgatgtccgt ccgatcaatg tacagaacag ctacacaatg
     4261 gaagcacgtg gcctgtggcg tatgaagggc gactttatgg gtggcccgta tgtatctcat
     4321 actcgtctgg acgagaaaaa ccaacgaatt ataacagcag aaatatttgt ttattcacct
     4381 gataaaatga aacgcaacct ggtacgccag atggaagcat ctctgtatac actgaaactt
     4441 ccgaatgaag ttcagcagaa tcagattcca ttgggagaag catctaagga agcggaacaa
     4501 actaataaat aaaaacatgg aagataacaa gataaggata ggtatcaccc aaggagatat
     4561 taatggggtg ggctatgagg tgattcttaa gacattttcc gaccctacga tgttggaact
     4621 atgtactccg atcatttatg gctcaccgaa agtagcggct tatcatcgca aagcgctgga
     4681 tatacagacc aatttcagca ttgtcaactc tgctaccgaa gcggggtaca accgtttgag
     4741 cgtggtgaac tgtacggatg atgaggtgaa agtggaattt tccaaacccg atcccgaagc
     4801 cggtaaagct gcgctggggg ctttggaacg tgccatcgaa gaatatcgcg aagggctgat
     4861 agatgttatc gtaacagctc cgatcaacaa acatacgatt cagtcggaag agttctcctt
     4921 ccccggacat acggaatata tcgaagaacg tctgggcaat ggtgataagt cattgatgat
     4981 tttgatgaag aatgacttcc gggtggcttt ggtgacgaca catatccctg ttagagagat
     5041 cgcgactacg attaccaaag aactgattca ggagaaactg atgatattcc atcgttgcct
     5101 gaaacaggat ttcggtatcg gcgctccgcg tattgcggtg ctctctctca atcctcatgc
     5161 cggagacggt ggtttgttgg gaatggaaga gcaggaagtg attatccctg ccatgaaaga
     5221 aatggaagag aaaggaatcc tttgctacgg cccttatgcg gccgacggct ttatgggttc
     5281 aggcaattat actcattttg acggtatcct ggcgatgtat cacgatcagg ggctggctcc
     5341 gttcaaggcc ttggctatgg aagacggggt gaactatacg gcaggcctgc cggtagtacg
     5401 tacttctccg gctcatggaa cggcatacga tattgcaggc aagggattgg cttgtgaaga
     5461 ttctttccgt caggcaatct atgttgccat cgatgtgttc cgtaatcgtc agcgggaaaa
     5521 agtggctcgt gccaatccgt tgcgtaaaca gtattacgag aaacgtgacg atagtgataa
     5581 actgaagctg gatacagtag acgaagatta aaaacgagtg atgacgagag cagagataca
     5641 acaagtgaaa caacgtttcg gtattattgg aaatactgaa gcattgtcgc gcgccataga
     5701 tgttgccatt caggtagctc ctaccgattt gtctgtgctg attaccggag aaagtggagt
     5761 cggaaaagaa agttttccgc agattattca tcaatatagc cggaggaagc acggacagta
     5821 tattgctgtc aactgtggtg ctattccgga gggcacgatt gattccgaac tgttcgggca
     5881 tgagaagggt gcgtttaccg gtgcgattgg cgaacggaaa gggtactttg gcgaagccga
     5941 cggtggtact attttcctag atgaagtagg ggagttgccg atgcctaccc aggcgcgttt
     6001 gctccgtgtg ttggagagtg gcgagtttat aaaagtaggt tcgtccaaag tgcaaaagac
     6061 ggatgttcgt attgtggcag ctaccaatgt caatctgaca caagcgattg cagaaggacg
     6121 tttccgtgaa gatttatatt accggttgaa tacggtgcct atccaaatac cgcctttgcg
     6181 tgaacgtggt gacgatgtac ttttgttgtt ccgtaagttt tccgcagact ttgcagagaa
     6241 ataccggatg cctgctatcc agttgacgga ggatgcgaag aaagagttat tggcttaccc
     6301 gtggcccgga aacgtgcgtc agttgaagaa catcaccgag caaatatcta tcattgaaac
     6361 caacagggag atctctgctg ctatcttgca gaattatctt cccgcacaaa atacgcaacg
     6421 tcttcccgcg ctgatgggaa cgcgtgagag taaaggcttt gagagcgaac gggagattct
     6481 ttattctgtt ctgttcgata tgcgccagga agtggcggag ctgaagaaga tggtgcacaa
     6541 cctgatggcg gaacgtgccg gacaggtggg acaggtagga caagtgggaa cggtggttac
     6601 tactccggta gtgacgacac accagccttc ggtacctgcg atcattcata ccatgcagcc
     6661 tgcggtttgc aaggatgatg acgacataca agacacggaa gaatatgtag aagaacctcc
     6721 tttgtcactg gacgaagtgg aaaaagaaat gatacgcaaa gcacttgaaa ggcatcacgg
     6781 aaagcggaag agtgcggcca aggacttgaa tatttccgag cgtacacttt atagaaaaat
     6841 aaaagaatat gaattggatt aagaaaataa tacgcccttt gctactgttc ggcttgccgt
     6901 tggtagtcat tgcgtgcact gtttcctata agtttaacgg atcgtctatc aattatgata
     6961 aggtaaagac catttcgata gccgacttcc cgatcaagtc ggagtatgta tatgctccgt
     7021 tggcaaccaa attcaatgag gacctgaaag atatcttcat ccggcagacc cgtctgcaac
     7081 tgctcaagcc gagtcaaaat gccgacttgc agattgacgg agaaatcaca gggtacaatc
     7141 agtacaacca ggcagtatct gccgacggtt attcttcgga gacgaagttg actatcaccg
     7201 tcaatgtgcg ttttgtcaac aacaccaatc atgccgaaga ctttgaacaa cagttttctg
     7261 cgttccgtac ctacgactct acccagttgt tgactgccgt acaggacgga ttgattgctg
     7321 aaatgtctaa agagatcacc gaccaaattt ttaatgcaac tgtagcaaac tggtaatata
     7381 aatgacttct gttaactttc aacaatggat tcagcatccc gagacgctga atagggatac
     7441 tttgtacgaa ctgcgcaatc ttcttgcgag gtatccgtat tttcagtcac ttcgtctgct
     7501 gtatctgaag aatctgtata ttctccatga tattagtttc ggtggagaac tgcggaaagc
     7561 agttctttac attgcagaca gacggcagtt gttccggttg attgaaggtg accgctatga
     7621 tgtgcaggca cggaaaaagg gaatacctct tacggaggtg ctgaaagacg aaccgtccgt
     7681 agaccgcaca ttagcattga tcgacgcttt cttgtccaca gtacccgaag aggtgactgc
     7741 ccggaccagt ttcgactatt cgatggatta cacttcttat cttttggagg agactccagc
     7801 cacggaacag ccggccgaag aaacgcccaa actcaaaggc ttcgaactga ttgacgactt
     7861 tatagaaaag agcgagagcg actctcccct ctgcatgaaa cctttaagag aagaaatgcc
     7921 atcttcgcca acctcttcgg acgaacttac cgaagaagaa acgatgaagg aagaagagga
     7981 agatgacagc tgttttacgg aaactttggc aaaaatctat gttaaacagc aacgatattc
     8041 aaaagctctt gaaataatta aaaaattaag cttgaaatat ccaaaaaaaa atgcttactt
     8101 tgcagaccaa atcagatttt tggagaaatt gattattaac agactaaccc gtataactta
     8161 cccgcaggta cggctgcgcc gcaaactgaa gctcctgcta ccaatgcacc tgctacagaa
     8221 actccggcac cggctgctga aactcctgct cctgcagcag agtaattcac tctgtcgtca
     8281 ggtaagactt tggggtaaaa ccattaatgg gaaggtgcag acggatgctg catttctttg
     8341 atatttaagt gcggattacg cagattacac ggattttcaa tcttccgcgt ggtcagtgta
     8401 atccgcactt aactttttct tgtaaaaaca atctctttgt gatagaaaca aacgagattt
     8461 aactaccttt gttggtcgta tgaagattat taactactat ttttaaatat aacaatgaca
     8521 gaacatttga aacaaaaatt gaatgactcc gccgtactcc gatggagtgt tctagcatta
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt ctggattatg gtttcttcac aagcgcttac
     8701 ggatggttta atgtattcct attgatgctg atcttcggtg gtatcatttt ggataagatg
     8761 ggagttcgtt tcaccggaat gggagcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tctttggatt caaaacacag
     8881 gtaaccctgg ccgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca agattatcgt gaaatggttc aagggtaagg aaatggcatt agctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgcttac ggttcctttg
     9061 gccgactttt tcggatctac ggatgagagt ggcacattcc ataccaatat tcctgctccg
     9121 attttgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagagggat tggaaccgga agagccgttc
     9241 cgtatgaaag atattgtgta tatcattacc aataaaggat tctggctgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtattcccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata atgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattatcc tgactccgtt gttcggctcg ctttatgacc gtatcggtaa gggagccaca
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgtttgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactattatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtact
     9661 gcatacgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgac
     9781 tacacgttgc cgatggctat ttttgctctc tttggtgtgc ttgctctgat tgtggctttg
     9841 atgttgaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tatccaaaag
     9901 taactaggaa attcaatacc taaagtgaca aaggaatttt gtatcaaggt gtaaacagaa
     9961 gagtatcagt ataaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 aaatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 acttataaaa ctggtgatac cagtcgtata aataggaact tattattatt tatttgataa
    10381 atacagccca aagtatgacg gcaattgcta tcaggacccc catgataata agcgttcccc
    10441 aaacaaaata attgctgtct ttctctttct ttttctccga gtcgtggatg atacgttcca
    10501 tttcttcggg ggtggtgttg ggtagtggat aaggttcgtt tgcacggttt aaatgcttca
    10561 acttatcgtt agcacgttca cgacgtaggc gggaagcttc ccgtccctct tttattcggc
    10621 gtatcatgtc gaatgcatgt ccttcaccaa ccatattctt tgttttttag aagttcactt
    10681 cctcattttt ctatttccct tcttctctgt ccactttgag caatcctccc gtattcggat
    10741 caaaataaac tttgatggta gaattcttgt tgaacaaaac cggagccaga tattctatca
    10801 caccaaattg agtaatagga agctcacctt cgtaaagttt ctttttaccg tcagtcagtg
    10861 taaccatagc ttgtccgggt acgttgtagg cgattccatc caaatctttc ttcttcttat
    10921 cgtcttcctg tggtatcttg accgatttca ggtctttcag actgatataa aacggagttc
    10981 ctgccaaatc attgttggca actacaccta acttcttcga gaagcggaaa gcaacttcat
    11041 tgttgaattc cttgtcaggg gtaaggcgga cagtgaatgt tctctcttct ttgttgcagg
    11101 tgccggagaa catttgcgtc atggcttctt cctgtgcatt cagattgtcg agcataattt
    11161 taagctgtgc cccatctgaa ggcatattat cagcttgtcc gcgcaataag gcatttttgc
    11221 tttcgcggat attatagatt tctttagcca ccagctcggc catcttagcg gtagagctag
    11281 ccatcagaat ctcttcggtc aggaattcgc gaggattcgc tttcttttgg aggactgcgg
    11341 gggcgggagc aacttttttg cctgcactgc tattgctgta aggaacattg atcgttttca
    11401 caatgccatc ctctgtcagt tccatgagcg gtgctactgt cttatccttc aattttacga
    11461 aatacgtagt ttcgctgttg ggcacaccta cggatttcac ttttacgcta gccagttccc
    11521 agtactcttc agggtcggcg gagacgttgg tcagtcgcag gtaacgatca gcatatttgc
    11581 tgaattctcc gggagtatag ttgactttgt tggcttttat ttcaagttct atttgggttt
    11641 tgggaagact gtaaaccact ccatagtctt ttcctcgggt aacccctgtc agtacttcgg
    11701 tttgtgcata ggcggacgtt gtcataagta gtcctgctgc tataatcaac tttttcatat
    11761 tcggttcttt ttaactggtt ttgaaaacaa agttaatgaa gttattgaaa aaagggtaac
    11821 ttcttaactt ttattcgctt acaagtcgcc atgctgtcgg cagacaggtg ataatatcgc
    11881 ttgcgatcat tccgatcatt ccttgcttct tttgagcgac atcgcccgcc agtccgtgaa
    11941 tgtaagtgcc gatttttgcg gcttcctcgg ttgggtaacc ttgggcaagt agtgccagga
    12001 ttactccggt cagtacgtca ccgctacctc cggttgccat tcccggattt ccggttgggt
    12061 tgaagaaaca tttaccttcg ggggtgatga tggcggagta ggctcctttt aaaataatgt
    12121 gaacatgggc ggcacgggcc agttcgcaag ccttcatcag acgttcgtaa gagtcctggc
    12181 atttgccggt cagacgttcc agttctttcg gatgcggggt gaggatggaa cccttcggca
    12241 ggtgggtaag ggcatggcgg tggttggcaa ggatattaag tgcgtcggca tccaccacaa
    12301 caggagtctg gcagtgttcc agttgttcca acaaggcagc ttccgtttcc tcgtttcgtc
    12361 ccagtcccgg accgatgccg actgcttgat agtcgtccgt gtcggtaggt acggcaaaac
    12421 aggtttcgtt gatgtcggtt tctacgattg cttcgggtat ggaggtttgc aagatgtcgt
    12481 tgttgcacat tggcgcatgg acagtcagta accctactcc cgaacggagg caggcgcggg
    12541 cagcaagaac agaggctcct gccattcctt ttgaaccggc aatcaatagt gcatggccga
    12601 agttcccctt gtgggcaaac tgtttgcgtg gcttgatgag tgaacggatt tgctctattt
    12661 ccaacatttc gtagttcgtt tccatctctt caataccgtc ttcgcttaat tggatgtcca
    12721 gcacttccca ttctccgaca aattccgtgt tctctgcgaa aagaaaggcg agcttcggca
    12781 gttgcagact gaaagttacg tcggcacgga taatattagc ttttacgttg aatgtatttt
    12841 cttctcccat cagtccggaa ggaatgtcga tggctactac catagtaggg gaggaattga
    12901 tgtattttac tacggcagcg aatccgccgc tcaacggttt gttcaggcct gaaccgaata
    12961 atccgtcgat taccagatgg tcgggcgtca gggcgggagg tacgaattgg gtactgatct
    13021 cgtggaattt tacttcttcc atcatttcta ccagttcttt attggtctgg cagtcgggtg
    13081 aaagttctcc tttcgtgttg aagagaaata cctcgatttt atatcctttt tcagccatca
    13141 tgcgggctac ggcgagagcg tctccgccat tattccccgg tccggcaaag atagtgaccg
    13201 gcgtttccgt attccatctg tctgtgatgg cttttgttaa tacggttgct gcacgttcca
    13261 tcagatcgat tgatgcaata ggttcgttct caatggtata agcgtccaat ttcttgatac
    13321 tgctgcttgg aaatattttc attgcgatgt tcttttagtt ttcggattac aaatgtacat
    13381 gattcttctg acttttcccg tttgttgtgg gaagaaaacc ataattgcaa cttttaattc
    13441 atcattagtt ctatcttttg gtcagagaaa tatctgtttt tgaactatta agtgttagaa
    13501 taactccgcc aaaaaataat tcaatgcagc accattatga acttactttt atttctcctg
    13561 aaaaagattt ctggttcttc gtcaaatttg gtggtacttc ttctattgtg aataaagaat
    13621 cttggctctc agtagtttac ttcctgccct attgtacatc tgccttttta
//
