LOCUS       c00116_gnlPro..        16196 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PBPAGIDJ_116.
ACCESSION   c00116_gnlPro..
VERSION     c00116_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 10:58:15
            Original ID  :: gnl|Prokka|PBPAGIDJ_116
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16196
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16196
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1639:6196]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1640..6196
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16196
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16196
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             451..1455
                     /locus_tag="ctg116_1"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSADHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPVTGVMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPQEEVATINQYGGALKAAIGIPEEWLRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAQ"
     CDS             complement(1640..2800)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_2"
                     /sec_met_domain="OAD_beta (E-value: 1.3e-153, bitscore:
                     501.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLVFIYLAIAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFVIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(2802..3233)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 7.2e-22, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPAAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             complement(3258..4178)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_4"
                     /sec_met_domain="OAD_gamma (E-value: 1.4e-15, bitscore:
                     48.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGKKLLDQIVVPAGTLGPNQSYARVSDGAAEW
                     EVKSGSGDKYVTPSTNNKTLDSNSKMEKFEEHDANGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             complement(4210..5763)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_5"
                     /sec_met_domain="CT_Btheta (E-value: 9.2e-290, bitscore:
                     951.6, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEYLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(5792..6196)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_6"
                     /sec_met_domain="Glyoxalase_4 (E-value: 2.3e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(6372..7370)
                     /locus_tag="ctg116_7"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNAFHSKELFQIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEIFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPVNWLRVRNSLHSMKKTEDRFSPSRI
                     RQIKKGLKNGAKVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNDMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDARQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWNWLNKLLVKFYV"
     CDS             7610..10849
                     /locus_tag="ctg116_8"
                     /transl_table=11
                     /translation="MRCNAFVEAWKNYHRRASMILGLSLLAAPLSYAVYAEDGVSNTMV
                     QVVTQTKTVKGTIIDESGEPLIGVSIVVKGTSTGTITDFNGNFFIDLPAGRKELVISYI
                     GYKEQTVTVTGNGPVNVKMVSDTQALDEVVVVGYGTMKKRDLTGAITSVKSEDVVMNPS
                     SNPMQALQGKVAGLDITRESGQAGSGVKMQLRGNRSFQKDSGNPLFIIDGMPGDYSTLN
                     PNDIESIEVLKDASSTAIYGSSGANGVILITTKGGKEGKAIVNFNAYVGVNGWSRTPEM
                     RSGESYIQTLRDASVGAGDGRWSSVADDKNLFTTDAEWNAHQNGQYIDWVDALLKTSVT
                     QNYSVSVAGGTEKTKAYFSLNFSNEDGQFAQDSYKLYSSKIRVDHKIKKWMKVGIDAQL
                     SYVHQNKADSDLQTLMASNPLGSLYNEDGSINPQPVADPSSTVYNYLLNEDKSLYRNQA
                     QNLKVYFNPYLEITPLKGLTFITRAGANLGYSRSNTFTGEGSVQWYKANQTADGIKAQV
                     KDNRSYNYKWENILTYNFQIKKVHDITLTAVTSWNHNRSDVTTLYQKGVSDNKFLWHNI
                     LDGNSATSGSTSYSMSKGMGYVGRLNYSYMGRYLFAASVRHDGSSRLAEGNKWDTFPAF
                     SLGWRISDEKFMESTTNWLSNLKIRFGYGVTGSTAGIDPYSSAASLDATAVNMILGGVL
                     TPIYKFSQNIPNYLLTWEKSYNTNIGIDAAFLNNRIDVSMEYYNTKTKDVIWNKALPVI
                     NGAFSPDGGPKANYTTNLNMCETSNKGFELALNTRNIITKNFTWSSSVTFNHNKEKITK
                     LSGGDSDVLNNGDTGYALALGEAINSYYHYKLDGVWQKGEETDAAVFGAAPGDLKINIP
                     NLVKESDGRFYKIDEETGSAAVDENGNVIYYTSDNKYTPSDADYQILGHNSPDWSLGFQ
                     NNFTWKDFDLSVFVYARYGQMFAYDMLTSYDPKGIRNFPTYFNYWTENNPSNDFPAANA
                     NKGLEQYTGYYALRYVDGSFIKIKNITLGYSLPKSILKSAGIEKCRFYATITNPFVFAK
                     SHLLKDYDPEMNGSLKYPLTKQFVFGVNVTF"
     CDS             10874..12895
                     /locus_tag="ctg116_9"
                     /transl_table=11
                     /translation="MKSTIYKIAALTFAVASMSACSLDEYNPSQKTGDEILATFDGLKG
                     LQSYCYSSLYGQLFSVYDFLSVAEGGTDCWVTPAGNPDYAKQVIYYDGLATNTNATNKL
                     FGQAYSMIGNCNAVVNRAELLTDGNEKDITTLVAEARCLRAFYYSILVNTYGNVTLTLE
                     ESSQDPILTPQRNSIEELYTQIIDDLKFAANNLEDTPYDNNRARVTKKTALGLLARVYA
                     QGGGEYGLTEDGVSYWQRAKEVAEDMILAYGDCLYDDVEDVWAPANNRNNKEALFIAAG
                     PDATNLENWNAGTQCNNNFTYMYPKPNTLTIYPTPDNQNYWYGRTNNNTLAPSKYLLDC
                     FDADYDKRWEVTFTTAFVQFSAVQSGGSYLFTKKQTLDDGTTPKIGTKHGVNDNISSFT
                     ILTQNIIDTYGLDAKFHNEYIYPYGDLNYTYYDGTWAPKMIAKVWPKGENSGDPSKLQE
                     VKNPYVIPYPVAEDDDRICFYLSKERLSDAEKAKRRYYVINIDDLFDNGQYRKTDIKVT
                     NDKNMYPGFNKYNWLSEDSYSSNLQRKTGDVFIMRMAEVYLIAAEANQQLGNGGKAAEY
                     LNVLKKRAARNDASYNAMKLSNATQDDVMDEYARELCGEYQRWVLMKRHKDSFKQRLAV
                     GNPRAAENFDENKHYLRPISFNFLSQIDNAEEYGNNGY"
     CDS             13002..13544
                     /locus_tag="ctg116_10"
                     /transl_table=11
                     /translation="MLEEILAYNKQFVENKGYESYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EVMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVRHPLIPSDVT
                     VYGFIIDSTTGELTRIV"
     CDS             complement(13634..13858)
                     /locus_tag="ctg116_11"
                     /transl_table=11
                     /translation="MKKRITQDDYIKANRKASREAEIEMYGHPICHKRVHQSKKVYNRR
                     KIKAADKKLPYFFVFKIASLSSRHSDTIQ"
     CDS             13860..14024
                     /locus_tag="ctg116_12"
                     /transl_table=11
                     /translation="MKLFICAKIQYILHLVEYLALFSCHRFPSDKRNEKDTFISYYARF
                     ALSLHTLIK"
     CDS             14038..14574
                     /locus_tag="ctg116_13"
                     /transl_table=11
                     /translation="MENFSELIKNRRSMRKFTDEELTQDQVVTLMKAALMSPSSKRSNS
                     WQFVVIDDKEVLKELSHCKEQASSFIADAALAIVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWVQVRERFTATGMPSDEFVHGILGIPLQLQILSVIAIGHKGMERKPFNEE
                     HLQWEKIHINKFGGK"
     CDS             14577..14912
                     /locus_tag="ctg116_14"
                     /transl_table=11
                     /translation="MGAAKASNSKDTYLATAVTFIVIGALYLIDKLIHFSTIGLPWVMN
                     KDNMLLYASICFLIFKRDKSIGFVLLGLWLVMNISLVISLLGSLSGYLLPLTLLIVGII
                     LFWFAKR"
     CDS             14920..15714
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg116_15"
                     /sec_met_domain="F420_oxidored (E-value: 6.1e-14, bitscore:
                     43.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSIEDTPIVFIGAGNLATNLAKALYHKGFRIVQVYSRTMESAR
                     TLAEKVEAEYTTDLQGVSKDAKLYIVSLKDAALVDLLPQITEGKQNSLLVHTAGSIPMS
                     IWEGHAERYGVFYPMQTFSKQREVNFQEVPFFVEAKRPEDVELLKAVAATLSEKVYEAS
                     SEQRKSLHLAAVFICNFTNHMYALAADLLEKYNLPFDVMLPLIDETARKVHELAPRDAQ
                     TGPAVRYDENVMNNHLAMLVDSPALQEIYKLMSKSIHEHHQL"
ORIGIN
        1 gaaggccttt tttcatttca gtatctgttt ttttaattta tattctgtta ctattttggt
       61 aagaaatagt gtaatggtca ttttcagagc gcaaagataa tgcttttctg tgaaatagaa
      121 aaaggttttc taaaatttct gatttctaat ttatgatttc tgatttgcta tgcagatttt
      181 ggtgattaaa tgaattgaaa aatgaggtat aaataaggta taaataagga gatataaatc
      241 cgaaggcata aatcagaatt cagaaatcat aaatcccaaa gtttgcaagg tggacattac
      301 aatctaatgt cacactcgta ttcctgctaa attttgcagt ctgatttaaa cctttttcta
      361 ctatattttt ctttccgatg ttcgttattc gatggataat gcttactttt gcgtagaatt
      421 tttattcact aacaataaac tttaaacaaa atggtaaatt acaaagattt aggattggta
      481 aacacaagag aaatgtttgc taaggctatc aaaggtggat atgctatccc agcattcaac
      541 ttcaacaata tggaacaaat gcaggctatc atcaaggctg ctgttgaaac taaatctcct
      601 gtgattcttc aggtttctaa aggtgctcgt cagtatgcta acgctacttt gttgcgttac
      661 atggcacagg gtgctgtaga atatgctaaa gaattaggct gcgcacatcc ggaaatcgtt
      721 cttcaccttg accacggaga tacattcgaa acttgcaaat cttgtatcga ttcaggtttc
      781 tcttcagtaa tgatcgatgg ttctcacctt ccttacgaag aaaacgtagc attgactaag
      841 aaagttgttg aatacgctca ccagttcgac gtaactgtag aaggtgaact tggcgtattg
      901 gctggtgtag aagatgaagt ttctgctgac caccacacat atactgaccc agaagaagta
      961 atcgacttcg ctactcgcac tggttgcgac tctttggcta tctcaatcgg tacttctcac
     1021 ggtgcttaca agtttactcc ggaacaatgc cacatcgacc cggttacagg cgtaatggtt
     1081 cctcctccat tggcattcga agtattggac gctgtaatgg aaaaacttcc gggattccct
     1141 atcgttcttc acggttcatc ttcagttcca caggaagaag tggcaactat caaccaatac
     1201 ggtggtgcat tgaaagctgc tatcggtatt cccgaagaat ggttgcgtaa ggctgctaag
     1261 tctgctgttt gcaaaatcaa catcgactct gactcacgtc tggctatgac tgctgctatc
     1321 cgtaagactt tcgctgaaaa accagctgaa ttcgacccac gtaagtatct tggcccggct
     1381 cgtgacaaca tggaaaaact gtacaagcac aaaatcatca acgtgctcgg ttctgacaac
     1441 aaattggcac agtaataatc tccggattat tccataaata aaagaaagag gctgctccgg
     1501 tttgaacacc ggtggcagcc ttttttatga cgtttaattg tttcagaacg gagagaagat
     1561 aacactatgg ctgtaataaa gaacacccgt gtcacaactg aatgtaacac gggtgttctt
     1621 atctattata taatgtttct tacatcaaga atccaagcag gataccggca gcaacagctg
     1681 aaccgatcac tccggcaacg ttcggaccca tagcgtgcat cagcaaatag ttggtcgaat
     1741 catattccaa accaatcact tgcgagatac gtgcagagtc gggaacagca gaaacacctg
     1801 cattaccgat caacggattg atcttattac ccttcttcag gaagatattg aagatcttaa
     1861 cgaagatgac accggaggca gttgcaataa caaatgacaa tgcaccgagg gcaaagatct
     1921 tgatagagtc aagcgtcagg aattcggatg cttgtgtaga agcacctact gtcagaccca
     1981 acaggatagt gattgtatca atcaacggac cactggctgt attagccaaa cggcgggtta
     2041 caccactttc tttcaacagg ttaccgaaga acagcatacc cagcaaaggc agaccggaag
     2101 gaaccaggaa acaagtcagc aacaaaccga tgatcgggaa aatcaccttc tccgtgtgag
     2161 aaacggcacg tggcggtttc atgcggatga cacgttcgtt cttggtggtg agcagacgca
     2221 tgataggcgg ctgtatcacc ggaaccaacg ccatatagga gtaggcggac accgcaatgg
     2281 ctcccatcag gttaggtgct agcttggaag aaaggaagat ggccgtcggg ccgtctgctc
     2341 caccaatgat accgatagca ccggcttgca tcgggtcgaa gcccatttct aacgcgatca
     2401 tataagcacc gaagataccg aattgtgcag ctgcaccgat cagcatcaat tttggattag
     2461 agataagtgc cgagaagtcc gtcatggcgc cgatgcccaa aaagatgagc ggcggatacc
     2521 agccggaggt cactccctga tacaatatat tcaatacaga accttcttca taaataccga
     2581 ctttcagccc ggcatccata ttaaaaggta tgttaccgat caatataccg aaaccgatag
     2641 gaatcagcag catcggttcg aactctttgg ctattgccaa atagatgaat accaagccaa
     2701 cgagaatcat gactacatgc cctaccgtag cattggcaaa gcctgtgtat gtccagaagt
     2761 cggccaggtt atttcctaaa aagtttataa agtctcccat attattcaat aattacgagg
     2821 tcattacctt caagaacaga gtctcccttg ttgacgttga tggcagtaat cttaccgtcc
     2881 ttatccgcat tgatattgtt ttccatcttc atggcttcca atatgataat ggtctgtcct
     2941 ttctttacag tatcgcctac attcactttg atgtcgagga tcacacccgg cagcggagat
     3001 tttactcctg attttccggt agacggagcg gtcggtttca ctacttgagt aggagcagca
     3061 ggagcattag gcatcgggcg tactgtcacg ggtttcgcaa caggcttcgg ctgtttctcc
     3121 atttctactt tatagtgtgt accgttcact tctacatgag cgatgttgtc ttcaatatct
     3181 ccgatggtta ctttatatga gttaccgttg attttatatt tatattcttt catcgttttt
     3241 actttttaaa aggtgactta ctttctggga ggagtttcac gcaaagtgta aatcttcgaa
     3301 ctccatggtg agtagctgcg ttttacgcgg gtgatggtca gcaccgtttc ttctacgtcg
     3361 tgcacctcat cctgcatttc gtgtaatgcc atagaaatag cagcgtatac ttcgcccgga
     3421 gcctgtgaca gttccttagc ttcatgcttg tcaatgcctt tagatttcat agcgttgcgc
     3481 ttgctcaaat taacagctac ttttcctaca atcttaaaag caataaagag aagaatcaat
     3541 ccgcagaata ctacgctcat ggcagaaatg gacattccaa cgccattagc atcgtgttct
     3601 tcaaattttt ccatcttgga attgctgtca agagtcttgt tgttggtgct cggagtcacg
     3661 tatttgtcac cgcttccact ttttacttcc cattcagctg ccccgtcgct tacacgagcg
     3721 tatgattggt tgggaccgag agtgcctgcg ggcactacaa tctggtcgag caactttttg
     3781 ccggagtcga acagaccaac ccaattagct gtttccggat tcagcttgaa gctggtatgg
     3841 aaagtaccac ggttaggttc gccatctgcc cagaatagtg catgttggcg tggtttcact
     3901 aaggtaagta tatcaccttt cgggataaaa taagtaactg tatcgcccgg ttggctgctt
     3961 actttcagca agcaagctgc caggtcggcg ctaccgaatg atttattgaa tatttcaatc
     4021 catgcgctgt gcaatccgta atcgtcctga aaattactct gattgtctat caggatttcg
     4081 tttagcacca gcttattgtt cgacttttgc tctccacaag aagtcagacc aatcagcaac
     4141 agcaaagaaa ggaatattcc gattttggtt ttgttcataa tcgttcttgt tttaatgtga
     4201 aaagtaggat tacaacggaa tattaccatg cttcttagcc ggattgctca atttcttagt
     4261 ctgcaactgc tgcaaagcac ggataacacg gaaacgtgtg ttgcgcggtt caatcacatc
     4321 gtcgatgtag ccatatttag ctgcattgta aggattggcg aacagtttcg tgtattctgc
     4381 ttctttctct gcaaggaatt gagcagggtt ttcctgatct ttggcttcgc gtgcgtacaa
     4441 tacttctact gctcctgcac cacccattac tgcgatttcg gcagtaggcc atgcgtagtt
     4501 catgtcaccg cgaagttgct tacagctcat cacgatgtga gaaccaccgt aagatttacg
     4561 taatgtaata gtaaccttag gcacagtagc ttcaccgtaa gcatacaaca gtttagcacc
     4621 atgaaggata acgccattgt attcctgacc tgttcccgga aggaatcccg gtacgtctac
     4681 caacgatacg ataggaatat tgaatgcatc gcagaaacga acgaaacgtg cacccttacg
     4741 agatgcgtta ctatcgagca caccagccag atacttaggc tgattagcaa cgatacctac
     4801 cgattgtccg ttgaagcggg cgaaaccgat gatgatattc tttgcataat ctttctggat
     4861 ttcaaggtat tcaccgttgt ccacaatagc gccgatcact tcgtacatgt catacggttt
     4921 agtagggctg tcggggataa tatcgttcaa agaatcttcc agacggtcga ttgggtctgt
     4981 gcaatctaca taaggagctt cttcaaggtt gttttgagga atatagctca acagtttgcg
     5041 aatcagttcg aaaccttctt cttctgtttg ggcggtgaaa tgagttacac ccgatttagt
     5101 ggagtgaacg cttgcgccac cgaggttttc ctggctaacg tcttcacctg taacggtctt
     5161 caccactttc ggtccggtga ggaacatata agaagtgcct tccatcatca gtgtaaagtc
     5221 ggtcagagcc ggagaataaa cagcaccacc ggcacaagga ccgaagatac cggaaatctg
     5281 cggaataaca cctgaagcaa ggatgttgcg ttggaagatt tctgcataac ctgccaaagc
     5341 gttgatacct tcttggatac gtgcaccacc cgagtcgttg ataccgatac aaggagcacc
     5401 catcttcatg gcctgatcca taattttaca aatcttcaat gacattgttt ctgacagtga
     5461 accggcagaa acagtgaagt cctgtgcgaa cacatatacc agacgtcctt cgattgtacc
     5521 gcagccggtt actacaccgt ctcccggata atgttttttc tccattccga agttcgtgca
     5581 tctgtgctca acgaacatgt ccatttcttc gaagctaccc tcgtcaagca gcatagccag
     5641 acgctcgcgt gctgtgtatt tccctttttc atgttgcttc gcaattgctt tttcaccgcc
     5701 tccgatacgt gctacggcac ggcgttcaat aagctcttta attttttcaa gttgattact
     5761 catgagttct tgttggtttt agagtttatg attaatgttc gcagagttct gtcaacacgc
     5821 ccaaagttga tttcgggtga aggaaagcaa tattcaaacc ttcggcaccc ttgcggggag
     5881 ctttgtcgat aaggcggatt tctttgcttt ctgcttctgc caaagcattg gctacgccat
     5941 cttctacagc aaaggctaca tggtgaacac ctgcaccttt gttttcaatg aatttggcaa
     6001 tagtactctc cgggcaagtc ggctccaaca gttcaatttt ggtttcgcct acttttaaaa
     6061 aagcagttct tactttctga tcttccactg tttcaatgtt gtaacacttc agacctaata
     6121 cattttcgta gtaaggaagg gcttcttcga tgctttttac agcaatgccc agatgttcaa
     6181 tgtgtgaaat cttcataact atactttttt tatttggttt taatcatgtg cttatatggc
     6241 ataaaacagc acaaagaaag acatttctta cctaataaag aaatatttct gcatttaatt
     6301 attggattat taaacagaaa aaatggtagg gaaggagcat gaagagtcgt tttgcaatct
     6361 tgagattaca tttagacata aaatttgact aagagtttgt tcagccaatt ccaattgaca
     6421 cggaaccagc ggcgggtact gctttgcttt cctccgaatc ggagaacgaa atcacgataa
     6481 ccgtgtttgc ggaacggaag tcctacatcc ataaattcca tgtgacggaa tccccgttgg
     6541 cgggcgtctt ccaatgcctt ccagacggcc aacactcccg gatactgaag tgcgtatgtc
     6601 tttctcattc ctccggaaaa ccaaaggtac gcgtcatctc ccgagtagat acagacggaa
     6661 ccgccaatga ttttctcttt gtattttact acgaatattt ttgcctgttg tcctttgatt
     6721 aacatatcgt tcatgtgacg gaaaaagtcg ttggcaggga aatatctgcg tatgcgggag
     6781 gaataaacct tgtgcagcat ccgtgagaaa tcgtgtattt cttccacggt atgtgcctcc
     6841 tctactttgg ctccattctt gagtcctttt tttatctgac ggatgcgtga cgggctgaac
     6901 cggtcttccg tctttttcat actgtgcagc gaattgcgta cccgcagcca attgacaggg
     6961 aaataatcat tggcacggaa aacccgatag ccgaacattg aattgtttag gttccggaat
     7021 tcgatcagga cacagctgcg cgatgcttct tgtgtgagat gttcgagcat atcgccaaag
     7081 atttcttctg ccttttcttt gttggtcgaa agcgactcat ccagaaattc accttcgcta
     7141 tatactacgc aatgtttcac taaagaggag ggaagccact ttttcgcttt gcggatggca
     7201 gcaagcaggc gtgccacagg tctgccgtct tctgttgcta ctattaataa aggagtatac
     7261 cccggagtcg cttcataaat ctgaaataac tctttggaat ggaaggcgtt ttttcccggc
     7321 aattcaggaa tgtccttccc atgataatat gtggttagtt taagtggcat ctaggtacaa
     7381 atttacactt tttattcttt attcaacaac aaaacaaaga ttttgttgga actgcctgaa
     7441 gtaaagtaca atatatcttt gcatatttaa tggaaaaaat gtattttata ggagaaatat
     7501 ggtatgaaaa gtgagtacgt attaaaatta ggttcgtctt aaattaagat tataatcgaa
     7561 tagtttttgc aaaacaacga gaattaatat taactttaaa ttagaacgaa tgagatgtaa
     7621 tgcatttgtt gaagcatgga agaattatca tagacgcgct tccatgattt tagggttgtc
     7681 tttattagct gcccctctgt catacgctgt ttatgcagaa gatggagttt ctaatactat
     7741 ggtgcaagtt gtcacacaaa cgaaaactgt gaaaggaact atcatcgatg aaagcgggga
     7801 gccgctgatt ggagtttcta tcgttgtgaa aggaacaagt acaggtacga ttaccgattt
     7861 taacggtaac ttctttatcg atcttccggc gggaagaaaa gaactggtca tttcttatat
     7921 cggttacaaa gaacaaacgg tgactgtgac aggcaacgga ccggtcaatg tgaaaatggt
     7981 ttcggatacg caggcattgg atgaagtggt tgttgtgggt tacggtacga tgaaaaaacg
     8041 cgatttgaca ggggctatca cttctgtaaa aagtgaagat gtagtgatga atccaagttc
     8101 aaatccgatg caggctttac aaggtaaggt ggcaggattg gatattacgc gtgaatcggg
     8161 acaggccggt tcgggagtaa agatgcagtt gcgtggtaac cggtcattcc agaaggattc
     8221 cggaaatcct ttatttataa ttgatggtat gccgggggat tattctacat tgaatccgaa
     8281 tgatattgaa agcattgaag ttttaaaaga tgcttcttcg acagctattt atggttcaag
     8341 tggtgcgaac ggtgttattt taattactac taaaggtggt aaggaaggca aagcaattgt
     8401 taattttaat gcatacgtag gtgtaaacgg ctggtcaagg actccggaga tgcgtagtgg
     8461 agaaagttat atacaaacct tgagagatgc atctgttggt gctggcgatg gacgttggag
     8521 ctcggttgct gatgataaaa atctgtttac tactgatgct gaatggaatg cacatcaaaa
     8581 tggccaatat atagattggg tggatgcttt gttgaaaacc agtgtaacac agaattattc
     8641 tgtttctgtg gctggtggaa cggaaaagac aaaggcatat ttttctctga acttctctaa
     8701 tgaggatgga cagtttgcac aagatagcta taaactttat tcatctaaaa tccgggtaga
     8761 tcataagatt aaaaagtgga tgaaggtggg cattgatgct caactgtctt atgtacatca
     8821 aaataaagct gattctgatt tgcagacttt gatggcgtca aatcctcttg gatcgttgta
     8881 taatgaagat ggaagcatca atccgcaacc tgttgccgat ccttcatcta cagtatataa
     8941 ttatctttta aatgaggata aaagtttgta ccgcaatcag gctcaaaacc ttaaggtcta
     9001 ttttaatcct tacttggaaa tcactcctct taaagggctg acttttatta ctcgtgctgg
     9061 tgctaatttg ggatattcac gtagtaacac tttcacagga gaggggtctg ttcaatggta
     9121 taaggcaaat caaacggcag acggcattaa ggcacaagtt aaggacaacc gttcgtataa
     9181 ttataagtgg gaaaatatac ttacttacaa tttccagatt aagaaagtgc atgatataac
     9241 tcttactgca gttacatctt ggaaccacaa tcgtagtgat gtcactactt tgtatcaaaa
     9301 aggtgtttct gataataaat tcttatggca taatattctt gatggtaatt ctgcaacttc
     9361 gggaagtact tcttatagta tgtctaaggg gatgggatat gtcggccgtt tgaactattc
     9421 atatatgggt aggtatttat ttgctgcatc tgtccgccat gacggctctt ccagactggc
     9481 agaaggtaat aaatgggata ctttcccggc tttttctttg ggatggagaa tttctgatga
     9541 aaaatttatg gagagtacga ctaactggtt gagtaatctg aaaattcgct tcggatatgg
     9601 tgttacgggt agtacagcgg ggattgatcc gtattcgtct gctgcatcat tggatgctac
     9661 tgctgtaaat atgatattag gaggtgttct gacaccgatt tataaattct cacagaatat
     9721 tccgaactat ttgcttacat gggaaaagtc gtataacacg aatattggta ttgacgctgc
     9781 attcttaaat aatcgcattg atgtcagtat ggaatattat aatacaaaaa caaaagatgt
     9841 tatatggaac aaggcacttc ctgttattaa tggagcattc tccccggatg gcggacctaa
     9901 agcgaattat actactaatt taaatatgtg tgagactagc aataaaggtt ttgagttggc
     9961 tcttaataca cgtaatatta taacaaagaa ctttacctgg agttcaagtg taactttcaa
    10021 tcataataaa gagaaaataa ccaaattgtc cggtggagat tcagatgtgc ttaataatgg
    10081 tgacaccggt tatgcattgg cattgggaga agctattaac tcttattatc attataagtt
    10141 ggatggtgta tggcaaaaag gtgaggaaac tgatgcggcg gtatttggtg ctgcacctgg
    10201 tgatttgaaa atcaatatac ctaatttagt aaaagaatct gatggtagat tctataaaat
    10261 agatgaagaa acgggtagtg ctgctgtgga tgaaaatggt aatgttattt attacacttc
    10321 tgataataaa tatactccaa gtgatgcaga ttatcaaatt ctgggtcaca actctccgga
    10381 ttggtcttta ggattccaga ataattttac ctggaaggat tttgatttaa gtgtgtttgt
    10441 ttatgcacgt tacggacaga tgtttgctta tgatatgttg acgtcttatg acccgaaggg
    10501 tatacgtaac ttcccgacct attttaatta ttggactgaa aacaaccctt caaatgattt
    10561 tcctgccgcc aatgctaata aaggtctcga acaatatacg ggatattacg cattacgcta
    10621 tgtagacggt tcgtttataa agattaagaa cattacattg ggatatagtc tgccgaaatc
    10681 tatcttaaaa tcagccggta tagagaagtg tcgtttctat gctaccatta caaatccgtt
    10741 tgtatttgcg aaaagccatt tgctgaaaga ctatgatccg gaaatgaatg gttctctgaa
    10801 gtacccattg accaaacaat ttgtatttgg tgtaaatgtt acattctagt ttttcactaa
    10861 aaaaagtatt gaaatgaaaa gtacaatcta taaaatagca gcgcttacat tcgctgtggc
    10921 ttcaatgtct gcctgctcgc ttgatgagta taatccaagc caaaaaacag gagatgaaat
    10981 tcttgcaacg ttcgatgggc ttaaagggtt acagtcttat tgttattcat cactttacgg
    11041 gcagttattc agtgtctatg atttcttgtc tgtggctgaa ggtggtacgg actgctgggt
    11101 aactcctgcc ggtaatccgg attatgccaa gcaggtgatt tattatgatg gtttagctac
    11161 gaatacgaat gctacaaata aattattcgg tcaggcttat tctatgatcg gtaattgtaa
    11221 tgcagtagta aacagggctg aattactaac ggatggcaat gaaaaagata taacgacttt
    11281 agtggctgaa gcccgctgtc tccgtgcgtt ttattattcc atattggtga atacgtatgg
    11341 gaatgtaacg ttaaccttgg aagaatcatc tcaagatcct attttgactc cgcagcggaa
    11401 ctctattgaa gaactatata cgcagataat tgatgatttg aaatttgcgg ccaataatct
    11461 tgaagatact ccttatgata ataatcgtgc gcgtgtgact aagaaaaccg cgttaggact
    11521 tttggctcgc gtttatgctc aaggtggtgg cgaatatggg ctgacagaag atggagtatc
    11581 ttattggcaa cgtgctaaag aagtggcaga ggacatgatt ttagcgtatg gtgactgtct
    11641 gtatgatgat gtggaagatg tttgggctcc ggcaaataat cgaaataata aagaagcttt
    11701 atttattgct gccggtccgg atgctacgaa tttggagaac tggaatgctg gaacacaatg
    11761 taataataac tttacttata tgtatccaaa gccaaatact ctcactattt atcctactcc
    11821 ggataatcaa aattattggt atggacgtac taataataat acgttggcac cttccaaata
    11881 tttgctggat tgttttgatg ctgattatga taagcggtgg gaagtaacct ttactacggc
    11941 ttttgtacag ttttctgccg tacagtcagg aggtagttat ttgtttacta agaagcagac
    12001 attagatgat ggtacaacgc cgaaaattgg aacaaaacat ggtgtaaatg ataatattag
    12061 ttcatttaca attcttactc aaaatataat cgatacttat ggattggatg caaaattcca
    12121 taatgagtat atttatcctt atggtgattt gaattataca tattatgatg gaacttgggc
    12181 gcccaaaatg atagccaagg tttggccgaa aggtgaaaat agcggtgatc cttccaaatt
    12241 gcaggaagtg aagaacccct atgtgatacc ttaccctgta gctgaagatg atgatagaat
    12301 ctgtttctac ttgtcaaagg aaagactttc ggatgcggag aaagcgaaac gtagatatta
    12361 tgtaatcaat attgatgatt tgtttgataa cggacaatat cgtaaaacag atataaaagt
    12421 cactaatgac aaaaatatgt accctggttt caacaaatac aattggttgt cggaagattc
    12481 atatagtagc aatttgcaac gtaagacagg tgatgtgttc attatgcgta tggctgaagt
    12541 atatctgatt gcagctgaag ctaaccaaca attaggaaat ggcggaaaag ctgctgaata
    12601 tttaaatgta ctgaaaaagc gtgccgctcg caatgatgca tcttacaatg ctatgaaatt
    12661 gagtaatgct acacaggatg atgttatgga cgaatatgct cgtgaattat gtggagaata
    12721 tcaacgttgg gtattgatga agcgtcacaa agattctttc aaacaacgtc ttgcggttgg
    12781 taatcctcgt gcagctgaaa attttgatga aaacaagcat tatttgcgtc cgatttcttt
    12841 taacttcttg agtcagattg ataatgcaga agaatatgga aacaatgggt attagtactc
    12901 ttacagatta aatttagatt aaagagggga tatgtcgtgg tgatatgtcc cttttttata
    12961 tatctttgcg taatcgaaca gaacttttaa aaagcggaac tatgttagaa gaaattttag
    13021 cttacaacaa gcaatttgtt gagaacaagg gatacgaatc gtatattact aataaatatc
    13081 ccgataagaa aatagctatt ctttcctgta tggacacccg actgactgct ttgcttccag
    13141 ccgcattagg aattaagaat ggcgatgtaa aaatgataaa aaatgcaggt ggcgttattt
    13201 cccatccttt cggtagcgtg atacgtagtt tgctcgttgc tatttttgag ttgggggtag
    13261 aggaaataat ggtgattgct cattctgact gtggagcttg ccacatgcac agtgaagtaa
    13321 tgctcgaaaa aatgaaagca cgcgggatca atccggatta tattgacatg atgcgtttct
    13381 gcggagttga ctttcattcg tggctggatg gcttcgaaga tacggaaaag tcggtgagag
    13441 gaacagttga ttttattgta cgccatcctt tgatcccttc agatgtgaca gtctacgggt
    13501 ttattattga ttctacgacc ggggaattaa ctcggattgt atagataatt agatagatta
    13561 ggtaaataga taaacttctt ttttaatccc ctaaatatag tgacgctatc ctatcatgat
    13621 agtgacgcca ttcctattgt atagtgtcgc tatgtctgga ggatagtgac gctattttga
    13681 agacaaaaaa ataaggcagc tttttatcgg ctgcctttat ctttctgcgg ttatatactt
    13741 tctttgactg gtgcactcgt ttgtgacaaa tagggtgtcc gtacatctca atttctgcct
    13801 cacggctagc tttacgattc gctttaatgt aatcgtcttg tgtaattcgc tttttcataa
    13861 tgaaattatt tatctgtgca aagatacaat atattcttca tttagtggag tatttggcac
    13921 tcttttcatg tcatagattc ccttctgaca aaagaaatga aaaagatact tttatttcct
    13981 attacgctcg gtttgcatta tctttgcata cattaatcaa atgaaaccgg aaataatatg
    14041 gaaaatttca gtgaattaat aaagaaccgt cgtagtatgc ggaagttcac cgatgaagag
    14101 ttgacacaag atcaggtagt tacgttgatg aaagcagctt tgatgtctcc ttcttccaaa
    14161 cgtagtaata gttggcagtt tgtagtgatt gatgataaag aggtattgaa agaattgtct
    14221 cattgcaagg aacaggcttc ttcattcatt gccgacgctg ctttggcaat tgtggtaatg
    14281 gccgatccgt tggccagtga tgtttggatt gaagatgctt ctattgcttc tatcatgata
    14341 cagttgcagg ccgaagatct cggcttggga agctgctggg tgcaggtccg cgaacgtttc
    14401 actgctaccg gaatgccttc cgatgaattt gttcatggaa tcctgggtat tcctctgcaa
    14461 cttcaaattc tttccgttat tgctatcgga cataaaggga tggaacgtaa acctttcaac
    14521 gaagaacatc ttcaatggga gaaaattcac ataaataaat tcggaggaaa ataaatatgg
    14581 gagctgctaa agcgagtaac agcaaagata cttatttggc tactgctgtt acctttatcg
    14641 ttatcggagc actttatctg attgataaac tgattcattt ctctactatt ggactacctt
    14701 gggtgatgaa taaagacaat atgttattgt atgcttcgat ctgttttctt attttcaaac
    14761 gcgataaatc aattggtttt gtgttacttg gtctttggct ggtgatgaat atcagtctgg
    14821 taatatcatt gctgggttcg ttatccgggt atctgctgcc attgactttg ctcattgtcg
    14881 gcatcatttt attctggttt gcaaaacggt aaggaaataa tgaagagaag tatagaagat
    14941 acaccgattg tgtttattgg cgcaggtaac ctggctacta atctggcgaa ggctctctat
    15001 cataaaggct tccgtattgt gcaggtatat agccggacca tggaatctgc ccgtacttta
    15061 gccgagaaag ttgaagctga atatactaca gatttacagg gagtctccaa agatgccaaa
    15121 ttgtatattg tatctttgaa agatgccgct ttagtagatt tgttgccgca gataacagaa
    15181 gggaaacaga attctttgtt ggtgcataca gcaggaagta ttccgatgag tatttgggaa
    15241 gggcatgcag aacgctatgg ggtattttat ccgatgcaga cattcagcaa acaacgtgag
    15301 gtcaattttc aggaagtgcc tttctttgtt gaagcgaaac gaccggaaga tgtagagctc
    15361 ttgaaagctg ttgccgccac tctttcggag aaagtttacg aagcttcttc cgagcagcgt
    15421 aaaagccttc atttggcagc tgtttttatc tgcaacttca caaatcacat gtatgcatta
    15481 gctgctgatt tgcttgaaaa atacaactta cctttcgatg tcatgcttcc gctgatagac
    15541 gaaacggcac gtaaagtaca cgagctggca ccgcgtgatg cacagaccgg acccgctgtc
    15601 cgttacgatg agaatgtgat gaacaatcat cttgccatgt tggtagattc tccggcattg
    15661 caggaaatat ataaactaat gagcaaaagt atccatgagc accatcaact atgatttatc
    15721 ccgtatcaag gctttagctt ttgatgtaga cggagtattg agttcgacaa ccgtaccttt
    15781 gcatccttcc ggagagccga tgcgtactgt gaatatcaaa gacgggtacg ccatccagtt
    15841 ggctgtgaaa aaaggacttc acatagccat catcaccggt ggccgtacag aagcagtgcg
    15901 tatccgtttt gaaggactgg gagtgaagga tctgtatatg ggatccgccg tcaagataca
    15961 cgactatcgt gattttcgtg ataaatacgg actgaccgat gatgaaattc tctatatggg
    16021 cgatgatgtt ccggatattg aagtgatgcg tgaatgtgga cttccatgtt gtccgaaaga
    16081 tgccgtgccg gaagtgaaat ccgtagcaaa gtatatctct tatgcagacg gcggacgtgg
    16141 ttgcggacgt gatgtagtgg agcaagtact gaaagctcat ggcttgtgga tggcag
//
