LOCUS       c00008_gnlPro..        15321 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PLKGMHMK_8.
ACCESSION   c00008_gnlPro..
VERSION     c00008_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 10:46:07
            Original ID  :: gnl|Prokka|PLKGMHMK_8
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 36133
            Orig. end    :: 51454
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15321
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[46133:49573]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13440
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15321
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15321
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(905..2020)
                     /locus_tag="ctg8_29"
                     /transl_table=11
                     /translation="MTDKRIYQIGLTMINGVGDILARHLLQALGEAEAVFTEKQQLLGR
                     IPGIGSNIAAEIKRPEILQRAEKELAFIEKNNISCYYLTDTDYPVRLRECPDAPILFYF
                     KGNTNLDATRIISIVGTRNATEYGRELTESLIKDLAKVIPDLLVVSGLAYGIDICAHRN
                     ALYNRLPTVAVLAHGLDRIYPSCHRNTAVEMLESGGLLTDFPSGTEPDRPNFLRRNRIV
                     AGISDCTIVVESAEKGGSLVTADIAFSYGRDVYSFPGRVGDSHSKGCNNLIRQNKAGLI
                     TSADDLLSALCWDIQAGATPVQTELFFAEAETFTSEQNPVLAIMRTRNEIHINELASVL
                     EIPVHQLSMLLFELEINGKVKALPGNLYKLS"
     CDS             complement(2017..2424)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_30"
                     /sec_met_domain="HBT (E-value: 2.8e-08, bitscore: 25.6,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 4.2e-09, bitscore: 28.5,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYIFKLTDKVRDYECDLQGVVNNSNYQHYMEHTRHEFLESLGE
                     NFGKMHEKGVDGFVSRVEIQYKTSLKSGDSYISCLNAYKKGVKLVFEQDIYRASDNALA
                     TKGIVESVIVENGKLTRGEYFDEMLKRIEHT"
     CDS             complement(2424..3683)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_31"
                     /sec_met_domain="Peptidase_U32 (E-value: 4.6e-69, bitscore:
                     223.6, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNEKDFEIMAPVGSYESLMAAIQGGADSIYFGIEGLNMRSRSSNN
                     FTTDDLRKIVALCREHGIKSYLTVNTVIYGEDLPLMREIIDAAKEAEVSAIIAADVAAM
                     NYANSIGQEVHLSTQLNISNAEALKFYARFADVVVLARELNLKQVHEIYRQIVDQQITG
                     PKGELIRIEMFAHGALCMAVSGKCYLSLHEMNASANRGACMQICRRAYSVKDKDSNIEL
                     DIENQYIMSPKDLKTIHFMNKMMDAGVRVFKIEGRARGPEYVRLVTECYKEAVRAYCNG
                     TFDEKKVAAWDERLRSVFNRGFWDGYYLGQRLGEWSSKYGSGATKKKVYVAKGIKYFDK
                     IGVAEFEMESGNLKVGDEILITGPTTGAVMQTIEEIRVDLKPVDETVKGERFSLKVNEK
                     IRPSDRLYKMEKVQLEKVFE"
     CDS             complement(3738..4934)
                     /locus_tag="ctg8_32"
                     /transl_table=11
                     /translation="MKKMLFGLMTAIATFTGCESKQPAGELPRIDLTATSFAFDQVEIA
                     DEIESIEYVPLELTDESLIADVLDLCVSDEYIFVYSTRQDGVLQFDRKGKYLRCIAKTG
                     NGPGETGQIISLTVDEENRLFCVSEYFSTSFYSFDGEFIKKIENPRPYSYQFSVGPNTM
                     AELGRMYVPMNTPGMFSLGVFNWGTDDTIAFRHTIGDMDLMPLEETSLKGWIFSGSKDG
                     ILCYSEGIDTVWDVNARNIAPAFLINTGYSVEEEKEMRSSKTGNEAVDGKYSVFSFFET
                     PRHYFVKCFEGSNQSKFYLYGLDKATGELKRETSPLNAQELFKNNWTLAGIGFRNTKDN
                     GLPIWPYLSYPGKKQMVQFNTAVEIEYLKEKYPDLKKHLVLQQITEDSNPLITIYHLR"
     CDS             complement(5001..6236)
                     /locus_tag="ctg8_33"
                     /transl_table=11
                     /translation="MIHNVKILFFICFFTACSSTEQKEIVTAGELLRQAAFYGERLQFL
                     PALETYQQAIKLAEKEKDSTVFSLAYLEMGKIYRYQSLKQKALQSEKKALSYIKSPACD
                     SLRLELYREIGDMYTLSGQADSAFHYYEMAGCRIKQAKILQQNGSNKEAETLLKTELEQ
                     TIFPKEKAEVCLALADLQITLGKLDEAEKSLSQVPPSHPHLYAALSRIAQSRGDSLQAD
                     FYHKSYLHHLSVLRQEKEQNQITQLLRTSEQKEWEKRLTDSQKAQKEQIYVWVTLLVSC
                     STGIWGYSRYRQKRNVVSLSETDFFSSEIYLRFHRKEEWKPVPKDWEELLQAFNRTYPD
                     FRERLKRKIPKLSEQEWRMCCLIKMEVPPSTAAMLLCCTNQAISMRRVRLYQKITGEKG
                     TPELCDSFIRDF"
     CDS             complement(6348..7316)
                     /locus_tag="ctg8_34"
                     /transl_table=11
                     /translation="MMLKKKSNNWARLKLALLVPVGFAALSAFARPETSPPPAATMTDN
                     IHLSINKSTVNQETMQQDHAVFLTYKESGSEDLNSIVCKTLDRIRTRVAEGQFKNALEV
                     TVNPAFDDIPASYLETVKDVLEERDIKCKIDMTVPNTIMDDVAKPYRKYDDVVYLIQNK
                     KIVAALSISKFSANQNDPRLDKISKSASLILQPENPKVSRQEMEKLKNLLDKKGLTSEI
                     NMNIFKIGDAAAPPPPPPAGQVIFSYRDGQPDQQFVLYDRHAKPGANLGQRIDKIYKDN
                     ITKVSIKINKSTPKDLLETVKQELKKKINYPVQYEILQFVD"
     CDS             complement(7484..8116)
                     /locus_tag="ctg8_35"
                     /transl_table=11
                     /translation="MDAFLLYILKSGICLTVFYVCFKALFSNDTFFRFNRWILLVGTGV
                     CMLLPLCRIQTARPFPLSRPVSQLEIVFYEEEMKAFPVPESKEEITIPTEQRNISVPWT
                     GIIGIAFLTGSGICLTTTILSFGKMYQLTRKNRKLKQGKYTLILTPDPVSPFSWGRYIF
                     LSENDYRNHPNEILMHEKMHLRYNHSVDLIYMKRFFFCNGLILPYGY"
     CDS             complement(8130..8486)
                     /locus_tag="ctg8_36"
                     /transl_table=11
                     /translation="MVRLTSKEEEILGYFWAKGPLFVRELLDLQEESKPHYNTLSTIVR
                     SLEEKGYIGYKVYGNTHQYYALVSEDEYRRNSLKQVISKYYDNSYTRVVSTLIEEEVLT
                     IDELQKLIQQIKNK"
     CDS             8646..9677
                     /locus_tag="ctg8_37"
                     /transl_table=11
                     /translation="MKIGTIDLGERPVFLAPMEDVTDISFRLMCKRFGADMVYTEFVSA
                     DALIRSVNKTQQKLNVADEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVK
                     RVAGKGAGAGMLRNIPLMLDITREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCG
                     IAALSIHGRTRAQMYTGEADWTLIGEVKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVD
                     AVMIGRGSIGRPWIFREVRHYLDTGETLPAESFSWYLDILKKQVEQSVERLDERRGILH
                     IRRHLAATPLFKGIADFKQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSES
                     IDC"
     CDS             complement(9650..9808)
                     /locus_tag="ctg8_38"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSIDSDT"
     CDS             complement(9805..9990)
                     /locus_tag="ctg8_39"
                     /transl_table=11
                     /translation="MYVYGKARRQWQRAFFMFVQTHKKAALPIIKVDAAFLLLSSETVS
                     RFPLCKDFVNLRSKIL"
     CDS             complement(10001..10756)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_40"
                     /sec_met_domain="Fer2_3 (E-value: 3.3e-26, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 9.8e-12, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1e-05, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             complement(10784..12727)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_41"
                     /sec_met_domain="FAD_binding_2 (E-value: 8.1e-60, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 5.2e-38,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFIPGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             complement(12766..13440)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_42"
                     /sec_met_domain="SucD_FumR (E-value: 3.3e-67, bitscore:
                     217.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLILFLVFHLCMNIAAVFSGEAYNVI
                     CGLLGSNWYALLGTLVLAAGVVVHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGVIVILFMVLHFTQFWYNMMFAELAGIHGDIHPQDGAAFINFYFQGNVVNTVLYL
                     IWFVALWFHLTHGFWSAIHTIGWNNTVWLSRWECISKWVATIICGLFAVITVIFYLNGV
                     GA"
     CDS             13700..14653
                     /locus_tag="ctg8_43"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSETSCSVVDTGKTLDYKIGDKLL
                     FSYNYTTVYPAPGVDSVYKRSGFIHPLKTLGGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFERD"
     CDS             complement(15037..15156)
                     /locus_tag="ctg8_44"
                     /transl_table=11
                     /translation="MKYNACVNLSNFSATLLKLSSRDGVISRMFFHEHLSLYH"
ORIGIN
        1 gaatcgtttt tcgagataga tccgcgtttg acaaaagacg ggataatcgt attgatgcac
       61 gacgaaacca tcgaccggac aactaccggg aaaggaaagg tttcagatta cacttatgca
      121 gaactgcaac aattcaatct ggtggaccga aacggcaacg tgacagcctt caaaattcca
      181 actttaaaag aatgcctgga atggagcaaa ggcaaaacaa tcctgaattt ggatatcaag
      241 gatgtacctt tagaagttat ggctgatttt atagaaacag aaaagcctgt taacgtcatg
      301 tacacggtac ataacgccag tcaagcccgc tattatctcg accggaaacc ggatgcgatg
      361 ttttcttgct ggtgtaagaa tcgggaagaa ttcgataatt atgaaaaagc cggcatcccc
      421 tggaaacagg taatggctta tgtaggcccg aagatgaagc ctgaacagca accactgtat
      481 gacgctctgc accgtaacgg agtcatgtgc atgatttccg ttgctccgac acatgatcgc
      541 gcgaaaacgg aaacagagaa aaccgccggt taccggtcag agatcagcac tcgtcccgac
      601 gtgatcgaaa cggactatcc gtacctgttt caaggactcg atttaacaaa ataacgcagt
      661 ttaaaggact ctttatagcc gattaaaatc tttttgctat ttatgctcat ctgattaaca
      721 agtattagca acaaaatgct tgacaaacgc tcttgacgag agtatctttg caatgtggtt
      781 ttttcataat agtattagat ttaaggttaa caaagttggt taggggttgt cgtgagacag
      841 cctttaattg tttatagagg ttccgtttct tctcccacat acaaatcgta tacgaaaaag
      901 ccggtcagga cagcttatag agatttcccg gcaacgcttt taccttcccg tttatttcca
      961 gttcgaacaa tagcatagag agttgatgta ccggtatctc caacactgag gcaagctcgt
     1021 tgatatgaat ctcattccgc gttcgcataa tggctaaaac cggattttgt tccgaggtga
     1081 atgtttccgc ttcggcgaaa aacaactccg tttgaacggg agtagcccca gcttggatat
     1141 cccaacaaag agcggagagc agatcgtccg cagaagtgat caggccggct ttattttgtc
     1201 ggatcaaatt gttgcatcct ttggaatggc tgtcaccgac acgccctgga aagctataga
     1261 catcccggcc ataagagaat gcaatatcgg cagttaccaa agagcctcct ttttctgccg
     1321 attcaaccac gatcgtacaa tccgagattc cggcgacaat ccggttcctc cggaggaaat
     1381 ttggacggtc tggttctgta ccgctgggaa aatcggtcaa cagaccgccc gattccagca
     1441 tttcgacagc cgtattccga tggcaggaag gatagatacg atccaagcca tgcgccagca
     1501 cagcaacagt cggaagtcgg ttgtacaaag cgttccggtg agcacagata tcgatgccgt
     1561 aagccaatcc actcacgacc aacaagtccg ggatcacttt tgccaagtct tttataaggg
     1621 attcggtaag ctcccgacca tattcggtcg cgttgcgagt acccacaata ctgatgatac
     1681 gggtcgcatc aaggttagta tttcccttaa aatagaaaag tataggggca tccggacatt
     1741 ctctcaagcg caccggataa tctgtatcag tcagataata acaggaaata ttgtttttct
     1801 cgataaaagc caactctttt tccgcccgtt gcaagatttc cgggcgtttg atttcggcag
     1861 caatattgct gccgatacca gggatccttc ctaacaactg ttgcttttca gtaaacacag
     1921 cctctgcttc tcccaaagcc tgcaggagat gacgcgccag gatatctccc acgccgttta
     1981 tcatagtaag gccgatttgg taaatccgtt tgtcagtcat gtatgttcta ttctttttag
     2041 catttcgtcg aaatattcac cgcgtgtcaa ctttccgttc tcaacgataa ccgactcgac
     2101 gattcctttc gtcgccaatg cattgtcaga agccctatat atatcctgct cgaatacgag
     2161 cttgactcct tttttatagg cattgaggca agagatatag ctgtcgccgc tcttgagcga
     2221 ggtcttatac tggatttcta cccgcgatac aaatccgtca accccttttt cgtgcatctt
     2281 tccgaagttc tcgccaagcg actccaagaa ttcatgccga gtatgttcca tataatgctg
     2341 ataattggag ttgttgacca ctccttgcag gtcgcattcg tagtcacgga ccttgtctgt
     2401 cagtttaaaa atatactctt tcattattca aatacctttt caagttgaac cttttccatt
     2461 ttatacaatc ggtcagacgg ccgaatcttc tcgttcacct tgagagagaa ccgttcacct
     2521 ttaacggtct cgtccaccgg cttcaagtcc acacggattt cttctatcgt ctgcataacc
     2581 gcacccgttg tcggtccggt aatcaggatc tcatcaccca ctttcaggtt accggattcc
     2641 atttcgaact ccgccacgcc gatcttgtcg aaatatttga ttcctttggc aacatacact
     2701 ttcttcttag tcgcgccgga gccatatttg ctactccact cacccaaccg ttgccccaaa
     2761 taatagccat cccagaatcc tcggttgaac acactgcgca ggcgttcgtc ccaagcggca
     2821 actttctttt catcgaacgt gccattgcaa taggcacgca cagcttcctt atagcattcg
     2881 gtcaccaggc ggacatattc gggaccgcgg gcacgtcctt cgatcttgaa tacccgtaca
     2941 cctgcatcca tcatcttatt catgaaatga attgtcttaa ggtctttagg cgacataata
     3001 tactggtttt cgatatccag ttcgatattg ctgtctttat cttttaccga ataagcacgc
     3061 cgacaaatct gcatgcaagc tccccggttg gcggaagcgt tcatttcgtg caggctcagg
     3121 taacatttac cggaaacggc catacagaga gctccgtggg caaacatttc gatacggatc
     3181 agttctcctt tcggtcccgt aatctgctgg tcgacgatct gccgatagat ttcatgcacc
     3241 tgtttcaaat tcagctcacg cgccaagacg acaacatcag caaaacgggc atagaatttc
     3301 agtgcttccg cattggaaat gttgagctgt gtggaaagat gcacctcctg tccgatgctg
     3361 ttggcatagt tcatagctgc cacatcggcc gcaatgatcg ctgaaacttc cgcctccttc
     3421 gccgcatcga taatctcgcg catcagaggc aggtcttccc cataaataac cgtattgacg
     3481 gtcaaatagc tcttaatacc gtgctcacga caaagcgcaa cgatcttgcg caaatcgtct
     3541 gtcgtaaagt tattggaaga gcgcgaacgc atattcaatc cttcgatacc gaaatagata
     3601 gaatcggctc ccccttggat agccgccatc agtgattcgt acgaaccgac aggcgccatt
     3661 atttcaaaat ctttctcgtt caagttctta tacatttact ggttcgttcg caaaggtagg
     3721 aataatatcc gagaagatca gcgcaaatga taaatcgtga tgagcggatt tgaatcttcc
     3781 gttatctgtt gcaggaccag atgcttcttg agatcaggat atttctcttt gagatattcg
     3841 atttccacgg ctgtattaaa ctgtaccatt tgttttttgc cgggataaga caggtaaggc
     3901 cagataggaa gaccgttgtc tttcgtattt cggaagccta ttcctgccag cgtccagttg
     3961 tttttgaata attcctgggc attaagcgga gaagtttcac gtttcaactc accggtagcc
     4021 ttatccaagc cgtacaaata gaatttggat tggttggaac cttcgaaaca tttaacgaag
     4081 taatgccggg gtgtctcaaa gaagctgaag acgctatatt tcccgtctac cgcctcatta
     4141 ccggttttgg aagagcgcat ttctttttct tcctcgacag aatatcccgt gttgataaga
     4201 aaagccggag cgatatttct tgcatttaca tcccagaccg tgtctatccc ttccgaatag
     4261 catagtatgc cgtccttact gccgctgaat atccaacctt tcaggctcgt ttcttccaac
     4321 ggcatcagat ccatatcccc gatcgtatgc cggaatgcga tcgtatcgtc tgtgccccaa
     4381 ttaaagactc cgagactgaa catgcccggc gtgttcatgg gaacatacat cctccctaat
     4441 tccgccatcg tattcgggcc aacagagaat tggtacgagt aagggcgcgg attctctatc
     4501 tttttgataa attctccatc aaaggagtag aaagaggtgg agaagtattc gctgacacag
     4561 aagaggcggt tctcttcgtc tacggttagc gaaatgatct gtccggtttc tcccggcccg
     4621 tttcctgttt tagcgatgca gcgcaagtac ttccctttcc ggtcgaactg caagacaccg
     4681 tcctgacggg tagaatagac gaagatatat tcgtctgaaa cacacagatc caatacgtct
     4741 gcgatcaggg attcatccgt tagttccaac ggaacatatt cgatggattc gatttcgtct
     4801 gcaatctcta cttgatcgaa agcaaaactt gttgctgtca gatcgatccg ggggagttct
     4861 ccggcgggtt gtttggattc gcatccggta aaagtggcaa tggctgtcat aagcccgaac
     4921 aacatctttt tcatacgctt tttttagaca aaagtagaag atacggctat ttccccggtt
     4981 tcacatcagt tcacatctgc ttaaaaatca cgaataaagg aatcacacag ctcaggagtg
     5041 cccttttcac ctgtgatttt ctggtacagg cgtacgcggc gcatcgaaat cgcctggttc
     5101 gtgcagcaaa ggagcatggc ggcagtagaa gggggaactt ccattttgat caggcagcac
     5161 atgcgccatt cctgttcgct caactttggt attttccttt tcagccgttc ccggaaatcc
     5221 ggataggtcc ggttgaaagc ttgcaacaat tcttcccagt ctttgggaac cggtttccat
     5281 tcttcttttc ggtggaagcg caggtagatt tctgaagaaa agaaatctgt ttcggacagg
     5341 gaaacgacat ttcttttctg ccggtagcgg gaatatcccc agattccggt actgcaagag
     5401 acaagtagcg tgacccagac atatatttgt tctttttgtg ccttttggct atcggttaaa
     5461 cgtttttccc attctttctg ttccgaggta cgaaggagtt gggtaatttg attttgttct
     5521 ttttcctgtc gcaggacgga taagtgatgg aggtagcttt tgtggtagaa atcagcttgc
     5581 aggctgtctc cacggctttg ggcgatgcgg gacagggcag catacagatg cgggtgggaa
     5641 ggggggacct gacttaaact cttttcggct tcgtccaatt ttcccaaagt aatctgcaaa
     5701 tcagccaaag ccagacatac ttctgctttc tctttcggga aaatcgtttg ttccaactcc
     5761 gtttttaata aagtttcagc ctctttattg cttccattct gttgcaatat ctttgcctgt
     5821 tttatccgac atccagccat ttcataatag tgaaaggcac tgtctgcttg tccggacaag
     5881 gtatacatat cccctatttc ccggtaaagt tccagccgta gcgaatcgca ggcaggactt
     5941 ttgatatagc ttaatgcttt tttctcactt tgtagtgcct tttgttttaa agattgatac
     6001 cgatagattt ttcccatttc caggtaggca agggaaaaga cggtgctgtc tttctccttc
     6061 tccgccaatt tgattgcctg ttgataggtt tccaatgccg gaagaaattg caatctttcc
     6121 ccatagaaag cagcctgtcg aaggagctct ccggcggtga caatctcttt ttgttcggta
     6181 gaagaacagg cggtgaaaaa gcaaatgaaa aagagtatct ttacattgtg tatcatctga
     6241 atccttcttt tgaaggagta aagataataa tattcctctc cgtttacccc ctggagcagg
     6301 ttttgtaaac ggagaggatg ataaatagat aatccgtgtt tctgatttta atcgacgaat
     6361 tgcaggatct cgtattggac agggtaattg attttctttt tcagttcttg cttaaccgtt
     6421 tccaacaggt ctttgggagt acttttgtta atctttatac ttactttcgt aatattgtcc
     6481 ttgtaaatct tgtctatgcg ttgtccgaga ttggctcccg gtttggcatg gcgatcgtat
     6541 aaaacgaact gttggtccgg ctgcccgtcc cggtaactga aaataacctg tccggcagga
     6601 ggtgggggag gtggagccgc agcatctccg atcttgaaaa tattcatgtt gatttcgctt
     6661 gtcaatcctt ttttgtccaa caagtttttt aatttctcca tttcttgtct ggatactttc
     6721 ggattttcag gttggagaat taaggaagct gatttggata tcttatccag cctcggatca
     6781 ttctggtttg cactaaactt actgatgctt agtgctgcga caatcttttt attctgaatc
     6841 agataaacca catcgtcata tttgcggtaa ggtttggcaa catcatccat gatagtattc
     6901 ggaacagtca tgtcgatctt gcatttaata tctctttctt ccaaaacatc ttttactgtt
     6961 tccagataag aagccgggat atcgtcgaag gccggattaa cagtaacttc cagggcgttc
     7021 ttgaattgtc cctccgctac tcgtgttctg attctgtcca gagttttgca tacaatactg
     7081 ttcagatcct ccgaacccga ttctttgtag gtgaggaaaa ctgcatgatc ctgttgcatc
     7141 gtttcctgat ttaccgtact tttgttaatc gatagatgaa tgttgtcggt cattgtcgct
     7201 gccggcggcg gacttgtttc cggacgggcg aatgcactta aggccgcgaa gcctaccggg
     7261 accaggagcg caagcttcaa ccgggcccaa ttgtttgatt tcttttttaa catcatagta
     7321 atacgttttt taattttact gtgattgaag ctgttggcaa gagtgtagag gctggagccg
     7381 acagcttttt tcacgagtaa tagttgatat tttgttgcat cgatgccttg actgagtacg
     7441 cctttatccg cctggtattc gtgtatgccc cgtaattccc tttttaataa ccatacggca
     7501 ggattaaacc attgcagaag aagaatcgtt tcatatagat cagatcgacc gaatggttat
     7561 agcggaggtg cattttttcg tgcatgagga tttcgttcgg atggttccgg taatcgtttt
     7621 ccgaaaggaa tatataacgt ccccaactga aaggggatac gggatcggga gtcaggatta
     7681 acgtgtattt cccctgtttt agtttcctgt tttttcttgt tagttgatac atttttccga
     7741 atgacagaat cgttgtggtc aggcagatac cactgcctgt tagaaaagca atcccgataa
     7801 ttcccgtcca gggaacagat atatttctct gctctgtcgg aatcgtaatt tcttctttgc
     7861 tttccggaac aggaaacgct ttcatctctt cttcatagaa aactatctcc agttggctga
     7921 ctggccggct aagaggaaaa ggccgggctg tttggatccg gcaaagtggc agcaacatgc
     7981 aaactcctgt ccctaccagt aatatccagc ggttgaaccg gaaaaacgtg tcgttactga
     8041 ataatgcctt gaaacagaca taaaagactg tcaggcaaat accagatttt aatatgtata
     8101 gaagaaaagc gtccataagc gttggttttt tatttgtttt ttatctgctg gatcagcttc
     8161 tgtaactcgt cgatcgtgag cacctcttct tctatcagcg tcgaaacgac acgggtgtac
     8221 gagttgtcat aatatttgct gatcacctgt ttcaaggaat tacgccggta ttcgtcttcc
     8281 gataccagtg catagtattg gtgcgtatta ccgtatacct tgtatccgat atatcctttt
     8341 tcttccaatg agcggacaat cgtggacaag gtgttataat gcggcttaga ttcttcctgt
     8401 aagtcgagta gttcgcgaac gaacaggggg cctttcgccc aaaagtagcc caatatttct
     8461 tcttcttttg atgttaatct aaccataatc cgttttttgt tagaggaatg cacaaataca
     8521 actatattat ttagtaacac aactatatca tatagttatt ttactatatt ttttagtaga
     8581 tatcctttta tccctgtttt tagcaggaaa tcagtacctt tgtccccgtc attgataata
     8641 taaatatgaa aataggtaca atagatttag gcgaacgccc cgtcttctta gctccgatgg
     8701 aagacgttac agatatttct ttccggttga tgtgcaaacg ttttggtgcc gatatggttt
     8761 ataccgaatt cgtttcagca gacgccctaa tccgcagtgt aaataaaaca cagcaaaagc
     8821 tgaatgtggc ggatgaagaa cgtccggtcg ccatacaaat atatggccgt gatgttccga
     8881 caatggtcga agccgcgcaa atttgcgaag ccgctcatcc ggacattctc gatatcaatt
     8941 tcggttgccc tgtcaaacga gtggcaggca aaggagcagg cgccggcatg ctgcgcaata
     9001 ttccactgat gctggacatc acccgtgaag tcgtcaaagc ggtgaacatc cctgtcaccg
     9061 taaaaacccg cttgggctgg gatgccgaca accggatcat cgtagacttg gccgaacagc
     9121 tacaggattg cggtatcgca gccctttcca tccacggacg tacccgggca cagatgtaca
     9181 caggagaggc agactggaca ctgatcggtg aagtaaaaaa caatccccgt atacaaattc
     9241 ccatcatcgg caatggcgat gtgacttccg ccgaaatctg caaacaacgt ttcgaacaat
     9301 atggcgtgga tgccgttatg attggccggg gcagcatagg ccgcccctgg attttcagag
     9361 aagtgaggca ttatctggat acaggcgaga cattgcctgc cgaatctttt tcatggtatc
     9421 tggacatact gaaaaagcag gtggaacaaa gcgtggaacg tttggatgag cgccggggaa
     9481 ttctccacat tcgccgccat ttggctgcaa ctccgctgtt taaaggtatt gcagacttca
     9541 agcagacacg cgtcgccatg ctacgtgcgg aaacagtgga agcattattc gacattctgg
     9601 attccatccc cgacaaattt catacaggat acggatttca aagcgactct caagtgtcag
     9661 aatcgatcga ttgttgatat aataacagtg tgaatccgca cacagtgtca attttaaaac
     9721 aaaaagtagc aaatttgcaa taaaatgtaa ttacaaactc ttgcgtattc agtaaatata
     9781 ctttatattt gcagtgagtt tttttcatag tattttagat ctaaggttaa caaagtcttt
     9841 gcagagaggg aatcgagaga ctgtttcact ggaaagcaac aaaaaagccg catccacttt
     9901 tattataggg agtgcggctt ttttgtgggt ttgaacgaac ataaagaaag cccgttgcca
     9961 ttggcgacgg gcttttccat atacatacat atataatgta ttagtcttgt aacttagcag
    10021 agatgaactc gcggttcaag cgagcgatgt tgctaacgga gatgttcttc ggacattcca
    10081 tttcgcaagc gcgagtgttc gtacagttac caaagcccag ttcatccatc ttagcaacca
    10141 ttgcttttgc acgacgagca gcttccacct taccctgagg caaaagagcc agctggctaa
    10201 cctttgcaga gacgaacagc atagctgaac cgttcttaca agcagcagca caagcaccgc
    10261 agccgataca agcagcagca tccatagcca aatccgcatc agccttagaa ataggaattg
    10321 cattagcatc aggaacccca cctgtgttta cagaaacgaa accacctgcc tggataatct
    10381 tatcataagc ataacggtct accatcaagt cgcggattac cgggaaacca gcagaacgcc
    10441 acggctcgat cgtaatcgtc tcaccatcat tgaaacggcg catatagagc tgacaggttg
    10501 ttgcacctgt tgccggtccg tgcggatgtc cgtttacata caatgaacac ataccgcaga
    10561 taccttcacg gcagtcgtgg tcgaatacga taggttcttt gccttcgcta accaaacgtt
    10621 cattcaaaat gtctaacatt tccaagaaag aaacactctg attgattttg tcgatttggt
    10681 aagtctcaaa ctgtccttta tctttcggac ctttctgacg ccaaacttta agtgttacct
    10741 ttatatcttt atccatgatt ctaatttttg tgattgatga ttattacttc ttgtagttac
    10801 gtgtttgagg aacaacgaac tgatagttca aatcttcctt cagcataacc gggtctttgt
    10861 cttcaccctg gtattcccaa caagagacgt acatgaactt atcgtcatga cgcatagctt
    10921 cgccttcttc ggtctgatgt tccgtacgga agtgaccacc acaagattct gcacggtcta
    10981 acgcatcgtg tgccatcaac gcaccgattt cgataaagtc agccaaacgc aatgccttgt
    11041 ccaattccac gttcaagcta ttggcctcac ccggaatgaa tacattgctc cagaattcct
    11101 tcttcaggtc tttcaacatt tggatagctt ctttcaagcc ttccgcgtcg cgtgccatac
    11161 cgacgtgttc ccacatgata tgtcccagct tacggtggat agaatcgact gtttctttac
    11221 ccttcacgtt catcaacttc gcgatacggg cgttaatagc cttttctgct tccacaaatt
    11281 caggcaggtc agtgctaaag cgcggaacct ggatctggtc agacagatag ttctggatcg
    11341 tgtaaggcaa tacgaagtaa ccatcggcca atccctgcat caaagcagaa gcacccagac
    11401 ggttagcgcc gtggtcagag aagttggctt caccaattgc gaacagcccc ggaatagaag
    11461 tcatcaattc atagtctacc cacaaaccac ccattgagta gtgcaatgca ggataaatca
    11521 tcatcggagt ttcgtacgga tcatcgttcg tgatctcttc gtacatatcg aacaggttac
    11581 catatttctg tttaaccact tccttaccca gacggttgat agcatcggag aaatccagga
    11641 atacagccaa gcccgtgcta tttacaccga aaccggcatc acaacgttct ttagcggcac
    11701 gtgaagccac gtcacgagga accaagttac cgaatgccgg ataacgacgt tccagatagt
    11761 agtcgcgatc tgcttcagga atatcctttc ccttttttgt tccggcctgc aatgccttcg
    11821 catcttccag cttcttcgga acccagatac ggccgtcgtt acgcagtgat tctgacatca
    11881 aagtcagctt agactggaag tcacctttca ccggcacaca agtcgggtgg atctgcacca
    11941 tacaaggatt agcaaagtaa gcccctttct tgtagcactg ccatgcagca gaaccgttag
    12001 acgccatcgc gttagtagac aagaagaatg tatttacata accacctgtc gcaacaacga
    12061 ctgcgtgagc ggcaaaacgt tcgatcttac cggtaatcaa attacgggca ataataccgc
    12121 gagcacgtcc gtcaaccttc acaacatcca gcatttcatg gcgtgtgtac atcttcacct
    12181 ttcccaaacc aatctgacga ctcaatgcag agtaagcacc caacagcagc tgctgtccgg
    12241 tctgaccacg agcatagaac gtacgggata cctgagcacc cccgaatgag cggttatcca
    12301 acagaccacc atattcgcga gcgaatggta caccctgtgc tacgcactgg tcgataatag
    12361 agtttgacac ttcagccaaa cgatagacgt ttgcttcgcg ggcacggtag tcaccacctt
    12421 tgattgtatc gtagaacaga cgataaaccg agtcaccatc attctgataa ttctttgccg
    12481 cattgatacc gccctgtgca gcgatagagt gtgcacgacg gggagagtcc tgaatacaga
    12541 aattcaatac attgaatccc atttcagcca gagaggcagc agcagaagca cccgccagac
    12601 cagtacctac tacaattatg tccaaacgac gtttgtttgc gggattcacc aatttctggt
    12661 gatttttata atttgtccac ttctcagcca acgggccttg aggaatttta gaatctattt
    12721 gagtcataat gttttatttt caaattgaaa aaataatatc cgaaattaag cacctacacc
    12781 gttcaggtag aagataactg tgataacagc gaataagcca caaataatag tggcaaccca
    12841 tttagagata cattcccaac ggcttaacca aacggtattg ttccagccaa ttgtgtgaat
    12901 cgcagaccag aaaccgtgag tcaggtgaaa ccacagagca acgaaccaga tcagatacaa
    12961 caccgtattc acaacattgc cctggaagta gaaattgata aacgctgcac catcctgcgg
    13021 atgaatgtca ccatgaatac ctgccagttc ggcaaacatc atgttgtacc agaactgagt
    13081 aaagtgcaga accatgaaca ggataacgat cacacccaaa acaaacatgt tctgagaagc
    13141 ccattcaaca cctttcggac gagcgttgat ggcataacgg tcgttaccgc gagccttacg
    13201 attctgcaga gtcaagataa tagcatacac gaagtgcacg actacacctg cagccaacac
    13261 caatgtaccg agcaaagcat accagttaga acccagcaaa ccgcaaatca cgttatacgc
    13321 ttcaccagaa aatactgccg caatgttcat acataagtgg aacaccaaga acagaatgag
    13381 aaaaagacct gatatactca ttatcagctt cttcccgata gaagaattaa gtaaccacat
    13441 aagataataa tttaagttat ttaattgtat ttagaaattt cctccaatct atggttatta
    13501 tcgtgcaaag gtatgctaaa tccccatatc acgcaaacga ttaaagaaat atttcatcaa
    13561 ttagaacgct gcttgctggc tggttttatt tgcatcagat atcacaaacg gattgtgcga
    13621 aacgaaaaaa tttcgttttt ttgtagccga tacaggcaag gtcttgccgg ataactgatt
    13681 attatttaat tgtcatatta tgaaaactgc tattttttct attggtgttt ttttgatttc
    13741 tctgttctta ggctcttgtc agccttccga aacatcctgt tccgtcgtcg acacggggaa
    13801 aaccttagac tataagatag gagataaact gttgttctct tacaactata ccacggttta
    13861 cccagcccct ggcgttgact cggtctataa acgcagcggt ttcatccatc ctttgaagac
    13921 attgggaggc gaagtgatga ccaattgttc tcccgccgac cattaccatc atttcggttt
    13981 gtggtatgcc tggacgaaaa ccacgttcga aggaaacgag atcgatttct ggaatctcca
    14041 caaaaaacaa ggaacagttc gcttccgcaa cttcgaacac gtatccgaca acggttttgt
    14101 tgcgacactg gaccatgtgg tctaccccga ttctcccgca gaaaaagtag caatgaacga
    14161 acgcctggag atcaacatcg ggacaacatc cttaccaggt tattacatcg actatcatac
    14221 cactatccgc ctcgccagcc ccagcccgat caccatggaa gcttaccgtt atggcggcat
    14281 atgcatccgt acgcgcgaag actggaacga tcagacagcc gaaatgctca cctcggaagg
    14341 cctttcccgc gacgaagctg acggttcgag agcccgttgg tgctactacc aagggaaagc
    14401 cggaaacgaa aaggcctgta tcctaatcgt tgcctcccct tccaacctaa actatcctga
    14461 gcccttacgc gtatgggaca aaactgtcaa caagcctgcc ggtgacgtca tgtggaattt
    14521 ctcaccgacc aagcagaagg cattcacatt ggaacccggt aaagaactga gcctgtctta
    14581 ccgcatttat gtattggaca agaacatcaa cgctactacg gcagaagtgc tgtccgattt
    14641 cgaacgtgat tgaatttcta ctaaaacaaa ctgacaattt gcagggcaag gtaaacaaga
    14701 aaaggaaaaa gggcttgttc tcctatatca tcaaagacaa ggctctttta tgtaaataca
    14761 gctacaaatc aatgaaaaac acgtaataaa acttacccaa cacccccatg tatccgcccc
    14821 cgacacccgg atctataaga gcgtaagatc cgggtgtcgg gggcggatac atgggggtgt
    14881 tgataaaatt gtctccctac ttttacctta aaatgcttgg agtttattca tttaaaacag
    14941 atagatgagc gattacagat agtgatagaa gcgtgatata taaaacaggt atctatcact
    15001 tcagatacgc actgattatc aagactcaca cgacatttag tgatagagtg acagatgttc
    15061 atgaaaaaac atcctagaaa tcaccccatc ccgactactg agcttcaata aagttgcact
    15121 aaaattagat aaattaacac aggcattgta tttcattgcc tattgccctt ttcccagttt
    15181 ttcgacagat acaaaatcat gttctgtgct gatgagaata tgcataacca caaaactttc
    15241 agacaaatat gcaatattat aaaaataaga ttattttttg accacccatg cacagaaaga
    15301 gatataagtt ctatcagaac t
//
