LOCUS       gnlProkkaFPLNEAEK_42   13220 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FPLNEAEK_42.
ACCESSION   gnlProkkaFPLNEAEK_42
VERSION     gnlProkkaFPLNEAEK_42
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 13:49:09
            Original ID  :: gnl|Prokka|FPLNEAEK_42
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13220
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13220
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2779:9786]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2780..9786
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..13220
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13220
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             complement(237..1178)
                     /NRPS_PKS="Domain: PKS_ER (12-220). E-value: 2.9e-12.
                     Score: 38.2. Matches aSDomain:
                     nrpspksdomains_ctg42_1_PKS_ER.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 200; E-value:
                     8e-61)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_1"
                     /sec_met_domain="ADH_N (E-value: 1.6e-12, bitscore: 37.2,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.4e-22, bitscore:
                     69.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEDALGPRENIILGHEACGVVVEVGEDVKDFKPGDRVLVPAITP
                     NWSDVYSQAGYATDSDGMLGGWQFSNIKDGVFATRFHVNDADGNLAHLPDEIDPTEACM
                     LSDMIPTGLHASEMAGVTFGDAVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEV
                     AKKYGATDIIDYHNGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSIGN
                     VNYLNGHDDVVFNAGDWGVGMGHKTIHGGLMPGGRLRMEKLAVLVVNGRIDPSLMITHR
                     FEGFEKIPDAIELMHHKSADLIKPVVICNDID"
     aSDomain        complement(519..1142)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg42_1_PKS_ER.1"
                     /evalue="2.90E-12"
                     /label="ctg42_1_PKS_ER.1"
                     /locus_tag="ctg42_1"
                     /protein_end="220"
                     /protein_start="12"
                     /score="38.2"
                     /tool="antismash"
                     /translation="ILGHEACGVVVEVGEDVKDFKPGDRVLVPAITPNWSDVYSQAGYA
                     TDSDGMLGGWQFSNIKDGVFATRFHVNDADGNLAHLPDEIDPTEACMLSDMIPTGLHAS
                     EMAGVTFGDAVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEVAKKYGATDIIDY
                     HNGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSI"
     CDS_motif       complement(714..740)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg42_1_0002"
                     /evalue="5.50E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg42_1"
                     /protein_end="155"
                     /protein_start="146"
                     /score="0.8"
                     /tool="antismash"
                     /translation="GAGRVFAVG"
     CDS_motif       complement(1101..1139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg42_1_0001"
                     /evalue="6.30E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg42_1"
                     /protein_end="26"
                     /protein_start="13"
                     /score="9.6"
                     /tool="antismash"
                     /translation="LGHEACGVVVEVG"
     CDS             complement(1189..1308)
                     /locus_tag="ctg42_2"
                     /transl_table=11
                     /translation="MKGFAMLGPNKTGFIEKEDPKVGSRDALVRPLAVAPVYF"
     CDS             complement(1539..2729)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 231.1; E-value: 2.9e-70)"
                     /gene_kind="transport"
                     /locus_tag="ctg42_3"
                     /transl_table=11
                     /translation="MDAKPNRRALSLGSFVILYLGYMLLFADRTVLNLSLAAIGKDFSV
                     SPAALGATSSVFFLGYTIMQIPGGWLTDRFSSRKVIIATLAFWSVMTIFTGLAWSLAAL
                     LVIRFLFGIAEGPYPPAAMKQVAQDFPVNKRAQLTAALISSNYAGAALAPFIIVPIIAA
                     TGWRSAFFWLGGFGLLLMVSYLFFRGHGGGQTVTKQERQKINWKEIDPRVWAFVVIGLA
                     LNIITKGMETWMPVYFLNARHINLANLAWLVPLPTIAGGIAALISGYVMVHIFKNHERL
                     MIILASFLTVLTMFGLYKSTSLVWLVIFQMATYFVKSLAFTGIFSYAAQLFPQKTYGSQ
                     IGTINFGGQLGGFFGPLLIGWIVQLSGSYDTAFFGLVISALVAGVASLFVGNLKAK"
     CDS             complement(2780..4204)
                     /NRPS_PKS="Domain: AMP-binding (8-379). E-value: 2.4e-71.
                     Score: 232.3. Matches aSDomain:
                     nrpspksdomains_ctg42_4_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     305.9; E-value: 7.2e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_4"
                     /sec_met_domain="AMP-binding (E-value: 9.7e-76, bitscore:
                     244.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITNWLLKQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQA
                     QTDQPRVGVMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDD
                     QLADRYYGGHRVLCSELTAGTAPAAVLTKTVDLDAVASIMYTSGTTGQPKGVLQTYGNH
                     LASAISSSLNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQIL
                     EDEPVTIISAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPVV
                     QCYGMTETCSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQ
                     PAKFAAKHDGDWYRTGDVGHFDEDGFLYVDGRLDEMIISGGENIFPAEVENVLRQYPGI
                     QEIAVVGRNDQQWGAVPVAVVVSKQPVDFQQLEAFGREHLAHYKVPKVYLQTDALPKNA
                     SGKVQKFRLQDLVANA"
     aSDomain        complement(3068..4180)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg42_4_AMP-binding.1"
                     /evalue="2.40E-71"
                     /label="ctg42_4_AMP-binding.1"
                     /locus_tag="ctg42_4"
                     /protein_end="379"
                     /protein_start="8"
                     /score="232.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="KQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQAQTDQPRVG
                     VMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDDQLADRYYG
                     GHRVLCSELTAGTAPAAVLTKTVDLDAVASIMYTSGTTGQPKGVLQTYGNHLASAISSS
                     LNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQILEDEPVTII
                     SAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPVVQCYGMTET
                     CSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQPAKFAAKH
                     DGDWYRTGDVGHFDEDGFLYVDGRLDEMIIS"
     CDS_motif       complement(3734..3784)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg42_4_0001"
                     /evalue="4.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg42_4"
                     /protein_end="157"
                     /protein_start="140"
                     /score="22.4"
                     /tool="antismash"
                     /translation="ASIMYTSGTTGQPKGVL"
     CDS             complement(4214..5035)
                     /NRPS_PKS="Domain: ECH (18-261). E-value: 2.8e-63. Score:
                     205.3. Matches aSDomain: nrpspksdomains_ctg42_5_ECH.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 198; E-value:
                     2.4e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_5"
                     /transl_table=11
                     /translation="MTSANWTPVKEYSEIIFERDDKIAKITMNRPEKHNAFTPVTVAEM
                     IDAFNICRDDSTIGVIILTGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIR
                     IIPKPVIAMVKGWSVGGGNVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVI
                     GHKRAKEVWFLNHFYTADEAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKA
                     AMNADTDGLAGLQQFAGDATMLYYTTDEGKEGRDAFNQKRDPDFDKFPKFP"
     aSDomain        complement(4253..4981)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg42_5_ECH.1"
                     /evalue="2.80E-63"
                     /label="ctg42_5_ECH.1"
                     /locus_tag="ctg42_5"
                     /protein_end="261"
                     /protein_start="18"
                     /score="205.3"
                     /tool="antismash"
                     /translation="RDDKIAKITMNRPEKHNAFTPVTVAEMIDAFNICRDDSTIGVIIL
                     TGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIRIIPKPVIAMVKGWSVGGG
                     NVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVIGHKRAKEVWFLNHFYTAD
                     EAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKAAMNADTDGLAGLQQFAGD
                     ATMLYYTTDEGKEGRDAFNQK"
     CDS             5070..5453
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144:thioesterase superfamily protein (Score: 97.2;
                     E-value: 9.8e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_6"
                     /transl_table=11
                     /translation="MNLLENLGIHQDLVTKDRVELSMPVQAKHLQPYGIVHGGINTVLA
                     ETAASLGANANVAPGRIAVGVNVTTQHIRAIREGEIFVVATPDHVGHTLQTWQARLLVN
                     DRLTATATITLMNVPAPTNNHKH"
     CDS             complement(5863..6240)
                     /locus_tag="ctg42_7"
                     /transl_table=11
                     /translation="MTNDINFWTGIKDPYLKPDKPFLTEDKELKIIHLIQSYPMHCPLC
                     GQLMRRNGFRKRPVTIKILTPAGKPAVLKIKKQQYLCPPSPQCPKRVTKVAEIQGVNFA
                     CRIANVVKYHIVQELSESVRN"
     CDS             complement(6452..7210)
                     /locus_tag="ctg42_8"
                     /transl_table=11
                     /translation="MMYEFPRLTAHHIQTTDQPVVTSTNEMAKERLKVKDQPFLISARQ
                     QTAGHGKTSRKFYSPAGSGAYFTLALPFSYLAKSAGQVTVTAAVAAYEVLSKQFTVPIT
                     IKWVNDLYCERKKVVGILAEMEMTANNQPRGIVVGWGINLAAPTVPLPPALQLRAGWLG
                     TTSIDDHQRLQIVDAVAAHFLDLLANASWKHILQVYQAHQYLINKLLLVDTGAGRVRGY
                     FDHITDDGWLCVQTDNGPRAFMTGTVRELV"
     CDS             complement(7225..9786)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     183.6; E-value: 1.1e-55)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_9"
                     /sec_met_domain="HMGL-like (E-value: 8.3e-37, bitscore:
                     116.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVEHTVTELITGIDIVKTQIRVAAGEDLHQDIGLPQQDDLKFHG
                     AAIQCRVTTEDPENNFMPDTGQVTTYDAPGGTGVRLDGNVYPGYKVTPYFDSLLVKCCT
                     RGEDFSDARIKMLRALEEFKIRGVKTNIPFMINVLKHPTFIAGKCSTTFIDENPDLFSF
                     AHRPDTPNQLLQYIGNVTVNGFAGVTKRTKLVLPNMQEPQAGQLTPNQHTTKTVKDILD
                     KQGADAAMQYVKDQPRVLLTDTTMRDAHQSLFATRMRTHDMLPAMKVYDRAMPNLFSVE
                     SWGGATFDVCYRFLGEDPWTRLRLLKKYMPHTLQQMLLRASNAVGYQNYPDNELKRFIE
                     HSAATGVDVFRIFDSLNWIDQMERSITYVRETGKIAEGTMCFTGDFLSPHEHKYTLDYY
                     MKLAQLLVDAGAQIIGIKDMAGLLKPKAAYELVGSLKAKFDVPVHLHTHDTTGNGVPTY
                     VAATNAGVDVVDVAMSSMAGTTSQPSLATFYYALEGDKRQPDLNMHNVAVLNRYWSNVR
                     PLYNDFSNGVNAPQPDLYQTEMPGGQYSNLKQQAQSLGINDFSLVEEKYREVNQLLGDI
                     IKVTPSSKVVGDMAIFMIQNHLDKDNILTKGQRVDFPESVVNFFAGDLGQPYRGFPKDL
                     QKVVLKDHSAITVRPGSLAKPVDFAAVKQELAAKINQEPSEDDLQGYIMYPKVFTTYFR
                     NHQRYGEVMDLDTTTYYQGMRPGEILHVKYGQGKEMIIKLDFVSAPDDDGDRFLFFELD
                     GRILKIKVKDNSMKDKVVSVSKADPDKSNEIGMPLNGNVVKVNVAEGDQVKVGDVLVVT
                     EAMKMESAVKAPFTGKVTKVYAKVGDALKSQDLLLTLTEDA"
     CDS             complement(9756..10661)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     412.9; E-value: 4.3e-125)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_10"
                     /sec_met_domain="ATP-grasp (E-value: 2e-11, bitscore: 33.6,
                     seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2e-12, bitscore:
                     36.7, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKKVLVANRGEIATRIIRACHELGIKAVAVYAKEDEYSAHRFAA
                     DEAYQIGAGEHPLDAYLDIDEVIRVAKESGAEAVHPGYGFLAENADLAQACIDNGLKFI
                     GPKPEHLRMFGDKLVAKRVAVEAGLQPIPGLSGDVKNVDQVKDFAHQYGYPIMVKAANG
                     GGGRGMRIINDDQQLTDEFDQAKDEALKAFGSDEMYVEKDVQHPKHIEVQIIADEHGHV
                     MHLFERDCSVQRRHQKVIEFALSVVLTPERRVEVCGLAVKLMKSVHYQNAATIEFLATP
                     DHFYFIEVNPGCRLNTPLPS"
     CDS             11362..12306
                     /locus_tag="ctg42_11"
                     /transl_table=11
                     /translation="MTRKVAVVGMGHVGATVAHYLVAGGFTDYLALYDTNEAKVRADAL
                     DLRDAMANLPFHTNLTVNDDSQLADCDVVISTLGKSKLVDTPDHDRFAEFKFTRTQVPL
                     VAKKLVDNGFHGKLVDVTNPCDVITSMYQKLTGLPKNHVMGTGTLLDSARMRACVGEAL
                     HVDSRSVVGFNLGEHGNSQFTAWSTVRVLGKRVLDLVDERHLDLTDMEERARQGGYMVY
                     KGKKYTNYGVATAAVRLTNALLSDARTEMPVSNYREEYGTYLSYPAVVGRDGVVEQLHL
                     DLTAAEKEKLATSAKYIKDRLAAEEQRAAQQDA"
     CDS             12673..12918
                     /locus_tag="ctg42_12"
                     /transl_table=11
                     /translation="MVIDTHTEIYDLLREYERTCVTITFKDGTSKKIFFLDVDDEYQEN
                     DVRPEKDCIVYNITDSISYGNGIPLDKLKSIETIKH"
     CDS             13062..13160
                     /locus_tag="ctg42_13"
                     /transl_table=11
                     /translation="MKIKAAVVEEQGAPFTIKDDVELAEIGPLSIK"
ORIGIN
        1 tcgtagaact gttcgcagtg gtgtatctat gcaaattgtg attcaaacac tcatcagaag
       61 ggtgcttgct cacaagctac tgactttagt cagtggtggt tgactttgcg tatgttagat
      121 agaaaacgtg gtcaataacc acaggcctag tgtctaagcc ggccgaagaa cgatgcgttc
      181 cgcccctagc ttagtcatac gacctgccaa gcaagttatt tgccactccc ttttaattag
      241 tcgatatcgt tgcaaattac gaccggcttg attaagtccg ccgacttgtg gtgcatcagt
      301 tcgatggcgt ccggaatctt ctcgaagcct tcgaagcgat gggtgatcat tagtgatgga
      361 tcgatccggc cgttcaccac gaggacggcc agcttttcca tccgcaggcg gccaccaggc
      421 atcaggccac cgtggatggt cttgtgaccc atcccaacac cccagtcacc ggcgttgaag
      481 accacgtcgt cgtgaccgtt taagtagtta acgttcccga ttgagccacc cggcttgagc
      541 atccggacgg cttcttcaaa ggtgtccttg gcgttcccac cggcgatcag gaccttgtcg
      601 accccttggc caccagtggc ttccaggatt tggtcggaaa tccggccgtt gtggtagtca
      661 atgatgtcgg ttgcgccgta ctttttagcc acttcgaccg tcttttcccg tgaaccaacc
      721 gcaaagacgc ggccagcccc gtggagcacc gccccgcgca gggccatcaa gccaaccggg
      781 ccgatcccaa tcacggcgac ggcatcccca aaggtcacac ccgccatttc ggaagcgtgg
      841 aggccagttg ggatcatgtc ggaaagcatg caggcctcgg tcgggtcaat ttcatccggt
      901 aggtgagcca ggttcccgtc ggcgtcgtta acgtggaaac gagtggcgaa gaccccgtcc
      961 ttgatattag agaactgcca gccgcccagc atcccgtcgg aatcagtggc gtagccagct
     1021 tgggagtaaa cgtcagacca gtttggcgtg atcgccggaa cgagtacccg gtcacccggt
     1081 ttaaagtcct tgacgtcttc accgacttcc acaaccaccc cgcaggcttc gtggccgaga
     1141 attatattct cccgtggccc taaggcatct tcaaacacgg tgtggatgtc agaagtacac
     1201 gggggcaacg gctaggggac gtaccagggc gtcacggctg cccaccttgg gatcttcttt
     1261 ttcaataaag cccgtcttgt tggggcccag cattgcaaaa cctttcattc ataactacca
     1321 cctttcttga ttagttgccg tcattctaac ataaatcatg ttataaccaa gtcttcatat
     1381 gtgagtttaa ttaattttaa agaaagcgtt ctcattccct gaaagggtta aaataacagg
     1441 gattatgata gttaagaaat tgattggaaa taaataaaat gactgtgata atcccgtacg
     1501 aggtcaccac agtcattaat cattctataa ttagcggatt atttagcttt taaattccca
     1561 acgaagaggg acgccacccc ggccaccaag gcggagatga ccaggccgaa gaaggccgtg
     1621 tcgtatgaac cgctcagctg aacgatccag ccgattaaga ggggaccgaa gaagcccccg
     1681 agttggccac caaagttaat cgtcccgatc tgggagccat aagtcttttg cgggaagagt
     1741 tgggccgcgt aggagaagat cccggtgaag gctagcgact tgacgaagta ggtggccatt
     1801 tggaagatca ctaaccaaac caggctggtg gacttgtaga gtccaaacat ggtcaggacc
     1861 gttaaaaagg aggccaggat aatcatcagg cgttcgtgat ttttaaagat gtgcaccatt
     1921 acgtaaccgg aaatcaaggc cgcaatcccc ccggcaatcg tcggtagggg aactaaccaa
     1981 gccaagttgg ctaagttgat gtggcgggcg tttaagaagt aaaccggcat ccaggtttcc
     2041 atccccttgg tgataatgtt taaggccagc ccgatcacca cgaaggccca gacccgcggg
     2101 tcgatttcct tccagtttat cttttgccgt tcttgtttcg ttaccgtttg tccaccgccg
     2161 tgaccgcgga agaagaggta gctgaccatc aagagtaggc caaagccccc caaccagaag
     2221 aaggccgagc gccaaccggt agcggcgatg attggcacga tgatgaaagg ggccagggcc
     2281 gcgccggcgt agttagagga aattaaggcg gcggtcagtt gggcacgctt gttgaccggg
     2341 aagtcctggg cgacttgctt catggcggcc ggtgggtaag ggccctcggc gatcccaaac
     2401 aggaaccgaa ttaccaagag ggcggctaag gaccaggcca gcccggtaaa gatcgtcatc
     2461 accgaccaaa aggcgagggt ggcgatgatc accttacggg aagagaagcg gtcggtcagc
     2521 cagccccccg ggatttgcat gatcgtgtag cccaagaaga agacggaact agtcgccccc
     2581 agtgcggccg ggctaacgga gaaatccttg ccgatcgcgg ccaacgataa gttaagcacg
     2641 gtccggtcgg cgaataagag catgtaacca aggtataaaa tcacaaagga accgagcgac
     2701 agcgcccggc ggttgggttt tgcatccatc atttatttgt atctttcttt tctcaattga
     2761 ttattctgct gtggcatgac taagcgttag cgaccaggtc ttgtaagcga aacttttgga
     2821 ccttgccgct ggcgtttttc ggtagggcgt ctgtttgcaa gtagaccttg ggtaccttat
     2881 agtgggccag gtgttcacgc ccgaaggcct ccaactgctg aaagtcgacg ggttgtttgc
     2941 tgacgactac ggccacggga acggcgcccc actgttgatc attacggccg accacggcaa
     3001 tttcttggat gcctgggtac tggcgcaaga cgttttccac ctcggcgggg aaaatgtttt
     3061 cgcccccgga gatgatcatt tcatctaacc gtccgtcgac gtacaagaaa ccgtcttcat
     3121 caaagtggcc gacgtcgccg gttcggtacc agtcgccatc gtgcttagcc gcaaacttgg
     3181 ccggttggtt taagtaaccc ggggttaagg ccggggtctg gatctcgatt tcgtgatgct
     3241 cacccaccaa acgcagctgg gtggtaaaca ggggcttacc gaccgaacca aggtggtaag
     3301 gcgcctcttc agccgagagg gcaacgaact gcgagcaagt ttcggtcatc ccgtaacact
     3361 ggacaaccgg cagcccactt tcttcgcagg cgttaagggt cgcccggtca atcgtcccac
     3421 cgccgagtag caccaggcga aaggccgatg agtaacagtg gtcatttgct tggacgtctt
     3481 cgagcatctt ctttagcatg tagggaacgg ccgaaatgat cgtaaccggt tcgtcctcca
     3541 ggatttggtt gaccacttgc gcatcgaaat ggttgactag gcgaacgccc atcccgtaaa
     3601 tcaggccccg cattagaatt gaaaagcccg aaatgtggaa gatgggggcg acgcacaacc
     3661 agaggtcgtt tggcaacacc ccgaggttca aagatgacga aatggcggag gccaagtggt
     3721 tgccgtaggt ttgcaagacg ccctttggct gaccggtggt tcccgaggtg tacatgatcg
     3781 aggccacggc gtctaggtca accgtcttcg tcaacactgc cgccggggca gtgccggctg
     3841 tcaattccga acagaggacc cggtgcccac cgtaatagcg atcggctagt tggtcatcga
     3901 ctaagactag gtcgagcccc gcgtcgccga tttggcgact cagttcttca ggggcgaggc
     3961 gccaatttag ccaaacgatg gtcttgtcgg cggctaagac ccctagggcg gctaagtaac
     4021 cagccaggtt attgtgggtc atcaccccaa cccggggctg gtccgtctgc gcttgaatct
     4081 ggccagcacg gtgggcgacc aggggaacca gctgggcaaa ggtgtaggcg gtggtaccgt
     4141 cgttaaccgc cacccggtta gggtttagcg aagcctgttt gaggagccaa tttgtaatct
     4201 ccatgacggc ctcctacggg aacttcggga acttatcgaa gtcggggtcg cgcttttggt
     4261 taaaggcgtc gcgcccttcc tttccttcgt cagtcgtgta gtaaagcatc gtggcgtcac
     4321 cggcaaattg ttgaagcccc gctaaaccat ctgtatcggc gttcatggcc gccttaatga
     4381 agcgaagggc ggtcggtgac ttctttaaga tttcatgaca ccagtctaaa gtaactgatt
     4441 cgacctcagc taggggcgcc accttgttaa tccagttcat ttggtaagct tcgtcagccg
     4501 tgtagaagtg gtttaagaac caaacttcct tggcccgctt gtggccgatc acccgggcta
     4561 ggtaacccga gccataaccg gcgtcaaagg aacccacctt cggccccgtt tgcccaaaca
     4621 tggcgttgtc ggcggcgatc gtcaggtcac aaaccagttg taagacgttc ccgcccccga
     4681 ctgaccagcc cttgaccatg gcaatcaccg gcttggggat gatccgaatc aagtgttgga
     4741 ggtccaaaac gttgagccgg gcgatgtggt cggggcccac gtaacccccg ttaccccgca
     4801 cggattggtc accaccggaa gaaaaggcct tatcgccggc tccggtaaga ataatcactc
     4861 caattgtgct atcatcacga cagatgttaa acgcgtcgat catttcggcg accgttaccg
     4921 gggtgaaggc attgtgcttt tccggccggt tcatcgtaat cttggcgatc ttatcgtcgc
     4981 gttcaaaaat aatttcggaa tactccttaa cgggggtcca gttagcactc gtcataacaa
     5041 actcctttac aaaatccaga ggtacaaaaa tgaatttact tgaaaactta ggcattcacc
     5101 aggacttggt gaccaaagac cgcgttgaac tctccatgcc ggtccaagca aagcacttgc
     5161 aaccgtacgg gatcgttcac ggcggaatta acaccgtact ggcggaaacc gcagcctccc
     5221 taggggctaa cgccaacgta gcgccggggc gaatcgcggt cggggtcaat gttaccacac
     5281 aacatatccg tgcgatacgg gaaggggaga tttttgtggt tgcaacccct gatcacgttg
     5341 gtcacacact tcagacctgg caagcccggc tgctggttaa cgaccgatta acggctaccg
     5401 caaccatcac cctgatgaac gtcccagcac caaccaacaa tcataaacat taattcacaa
     5461 attggctact attatgctta gaaagttgct gggtgaccat tgggggatta cctaaatcac
     5521 atttttttaa ttttatatta tgtaaatcaa tcgagaagtc gtcggctaac tgttatgaaa
     5581 ggggcgccac tacgcagtcg atttaagttg gccccgattt tgtattagtg ttgcaaccag
     5641 tacgcaaaag cacacataat ttatcgaggg gaggaccaga tatgaggaaa tggtgggtgg
     5701 aattgaaact ggtcgtcttt tgcatcgccg ctcttttcag gtaattactc taacggcgct
     5761 aattagactt acttctgtaa attcacatta tgtaaagata tcgtttgatg attaaagaag
     5821 cctcaaaggc cctccgagga tgacaataca gatgttcaag acttaattac gtacgctctc
     5881 actgagttcc tgaacaatat ggtatttaac gacattcgca attcgacagg caaaattaac
     5941 tccttgaatc tcggcaacct tggtaactcg cttggggcat tggggcgatg gtggacagag
     6001 atactgttgt ttcttgattt ttaagacagc tggttttcca gccggtgtaa ggattttgat
     6061 cgttacgggc cgcttacgga agccattacg acgcatcaac tggccgcaaa gcggacagtg
     6121 catgggataa gactgaatta aatggataat ctttagttct ttatcttcag ttaaaaatgg
     6181 tttgtcaggt tttaagtaag gatccttgat tccagtccaa aaattgatat cattagtcat
     6241 gaggaatata tcctttctaa gacaactgag tggttatggg gataacttaa gacagttgtc
     6301 ttttttattt ttaaatcaat ggtacagcaa gtaacaaaaa acggtaaaga caagaaatca
     6361 tcttatcctt accgaatatc atagaacctt caaggataac tgcggtcaaa acacgtccgc
     6421 gtttgtccaa gaaggactgc ttttttaatt actaaaccag ttctcgaacc gtccccgtca
     6481 tgaatgcgcg gggcccgtta tctgtctgca cacataacca gccatcatcc gtaatatggt
     6541 caaagtatcc cctaacacgt cccgctcctg tatcaacgag gagcagcttg ttaataaggt
     6601 attgatgagc ctggtaaacc tgcaggatgt gtttccagga cgcgtttgct aacaggtcaa
     6661 ggaagtgcgc agcgactgca tcaacgattt gtagccgttg atggtcatca attgaggtgg
     6721 tgccgagcca tcccgcacgt aactgaagtg ctggcggcaa gggaacagtt ggtgccgcca
     6781 ggttaatccc ccagccgacc actattcccc gcggctgatt attcgcggtc atttccattt
     6841 cagcaagaat ccccaccacc ttctttcgct cacagtacag gtcgttcacc catttaatag
     6901 taatgggaac agtgaattgc ttgctgagga cttcataagc agcgaccgcg gcagtcaccg
     6961 ttacctgacc agcacttttt gccaggtagc taaagggtaa ggcaagggtg aagtaggccc
     7021 cacttcccgc gggtgaataa aacttccggc tggtctttcc gtggcctgcc gtttgctgcc
     7081 gggcggagat gagaaagggc tgatctttca cctttaaccg ttcctttgcc atttcgttag
     7141 tcgaagtgac cactggctga tcggttgtct ggatatgatg tgctgtcagt ctaggaaatt
     7201 cgtacatcat tgctactctc cttatcaagc atcctcagtc aatgttagta agaggtcctg
     7261 actctttaac gcatcgccaa ccttagcgta tactttcgtc accttaccag taaatggcgc
     7321 tttaactgct gattccatct tcatcgcctc agtaacaacc agaacgtcac caaccttgac
     7381 ctggtcacct tctgctacgt taaccttgac cacgttcccg ttcaacggca tcccgatctc
     7441 attactctta tcgggatcag cctttgaaac actgacaacc ttgtccttca tgctattgtc
     7501 cttaactttt attttaagga tccgcccgtc cagttcaaag aagaggaagc gatcaccgtc
     7561 atcatctggt gctgaaacaa agtcgagttt tataatcatt tcttttccct gaccatactt
     7621 aacatgcaaa atttcaccag gacgcatgcc ttgatagtag gtcgtggtat caaggtccat
     7681 cacttcaccg tatcgctgat ggttgcggaa gtaagtggta aagactttcg gatacatgat
     7741 gtaaccctgc aggtcgtcct cgctcggttc ctggttgatc tttgcggcca gttcctgctt
     7801 aacggcggca aaatcaaccg gtttagcaag gctcccgggc cgaaccgtga ttgcagaatg
     7861 gtccttcaag acaaccttct gtaggtcctt ggggaagccc ctatatggtt gaccaaggtc
     7921 gccagcaaag aagttaacca ctgattctgg aaagtcgact cgttgcccct ttgtcaggat
     7981 attgtcttta tcaaggtggt tttggatcat gaagattgcc atgtcgccaa ccaccttcga
     8041 gcttggcgtc accttgatga tgtcaccgag caactgattg acctcccggt atttttcttc
     8101 caccaggcta aaatcattga ttcctagtga ctgggcctgt tgcttcaggt tcgagtactg
     8161 gccacctggc atttccgtct ggtataggtc tggttgcggt gcgttgaccc cgttgctgaa
     8221 gtcgttgtaa agcggccgga cattggacca gtaccggttt aagaccgcca cgttatgcat
     8281 attaaggtcc ggttggcgtt tatctccttc tagcgcgtag taaaaggtgg ctaaactagg
     8341 ctgactggtt gtccccgcca ttgaagacat cgccacgtcc accacgtcaa cacccgcatt
     8401 tgtggcggca acgtaggttg gaactccatt acccgttgtg tcatgagtgt ggaggtgaac
     8461 aggaacatca aacttagcct tcaaactacc gactagttcg taagcggcct ttggtttcaa
     8521 gaggccggcc atatccttaa taccaataat ctgcgctccc gcgtcgacta ataactgtgc
     8581 caacttcatg taataatcta gggtgtactt gtgctcgtga ggactaagga agtcgccggt
     8641 aaagcacatt gttccttcgg cgattttgcc ggtttcccga acatatgtaa tgctacgttc
     8701 catctggtca atccagttga gggagtcaaa gatccggaaa acatccaccc cggttgcggc
     8761 actgtgctca atgaaccgct tcagttcatt atccggataa ttctggtaac cgaccgcgtt
     8821 cgacgcccgc aacaacatct gctggagagt atgtggcatg tacttcttca ataatcgtaa
     8881 tcgggtccac gggtcttcac caaggaaccg gtagcacacg tcaaaagttg ccccgcccca
     8941 gctttcaaca gaaaagaggt taggcatcgc ccggtcgtaa accttcattg cgggcaacat
     9001 atcgtgcgtc cgcatccgag tggcaaaaag gctttggtga gcatcacgca ttgtggtatc
     9061 agtcagtagt accctcggct ggtccttaac atactgcatc gccgcatcgg ctccctgttt
     9121 atccaggatg tcctttactg tttttgttgt atgctggtta ggtgtaagtt ggcctgcttg
     9181 tggttcttgc atgttaggca aaacaagttt ggtccgcttg gttacccctg caaagccatt
     9241 gacggtaaca ttgccaatat attggagcaa ctggttaggc gtatcgggcc ggtgcgcaaa
     9301 gctaaagagg tcgggattct cgtcgataaa cgttgtcgag cattttccgg caataaacgt
     9361 gggatgcttt aacacgttga tcatgaaggg aatattagtt ttgactcccc gaatcttgaa
     9421 ttcttcaagc gcccgcagca tcttaatccg ggcatcactg aagtcttcac cccgggtaca
     9481 acacttaacg agcaaggaat caaagtaagg agtgacctta tagccgggat agacgttccc
     9541 gtcaagccgg acaccggttc cccctggcgc atcataggtc gtaacctgtc ccgtatctgg
     9601 cataaagtta ttctcgggat cttctgttgt gacccggcac tgaatggctg ccccgtggaa
     9661 cttgagatcg tcttgctggg gaaggccaat atcttgatga agatcttcac cggccgcaac
     9721 ccgaatctgg gtcttaacaa tatcaatccc agtaatcaac tcggtaacgg tgtgttcaac
     9781 ctgcacccgg gattaacctc aatgaagtaa aaatgatccg gggtcgccaa gaattcgatc
     9841 gtcgccgcat tctggtagtg aacactcttc atcagcttga cggccaggcc acaaacttcg
     9901 acccgccgct caggggtcaa gacaacgcta agtgcaaatt caataacctt ctggtggcgg
     9961 cgctggacag agcagtcacg ttcaaagagg tgcatcacat gcccgtgctc atcagcaatt
    10021 atctgcactt caatatgctt cgggtgttgg acgtcctttt cgacatacat ctcatccgat
    10081 ccaaacgcct tcagcgcctc atccttcgcc tgatcaaact cgtcggtgag ttgctggtcg
    10141 tcattgatga tccgcatccc ccgaccgcca ccaccattag cagccttaac catgatcggg
    10201 taaccatatt ggtgggcaaa atcctttacc tggtcaacat ttttaacatc ccccgataaa
    10261 ccgggaattg gttgcagccc tgcctcaacg gccacacgtt tagcaaccaa cttatcccca
    10321 aacatacgaa ggtgttccgg cttaggtcca ataaacttta atccattatc aatacaggcc
    10381 tgcgcaaggt cagcgttttc tgccaggaag ccataaccag ggtgaacagc ttctgccccg
    10441 ctttctttgg ccacccgaat tacttcatca atatccaggt aagcatcaag cggatgttca
    10501 ccagccccga tttggtacgc ctcatcagca gcaaagcggt gcgcactata ctcatcctcc
    10561 ttagcataaa ctgcgacggc tttgattccc agctcatgac aggcgcgaat aatccgtgta
    10621 gcaatttcac cacggttagc aactaaaact tttttaaaca caattatcca ccatcctttt
    10681 tattaatcct tcacgcccat cacgtcatta ctattggcgg tgagggtggc tgtatttgta
    10741 gaaatattaa tattaccaac cattgcactc acctcctcat ttttctaatc aaattttaaa
    10801 acaaactata atcaatctaa gctaacgtgt caataatttt tcctcaagaa atgcccgcta
    10861 ttaaacgaat ttatactata aattgtctgc ctttgcaccc atcttttctc atcttttttt
    10921 aatttttatc ttgacttccc tatctgccta gtgatatagt acttaacaat caattgaaac
    10981 aagttaaaga cgttgagcga gaaacagcga tgaggccgaa gcaagagagc tggtgggtgg
    11041 tgtgaaccag tgagaggccg cacctgctaa tcactcgtga gtcgtacgcc gaacggattc
    11101 cctagtagag cgtattggta gcacccatta ccgtgccggc taataccaca ttatttgtgg
    11161 cggttggttg aggcgacatt atgtcgtaaa gaaaggtggt accacgcaca agcgtccttt
    11221 ttagttctta gatttatcaa gagctagaaa ggacgctttt tgttttgata ttaaaggtgg
    11281 tggtgatcat ggcagacagt gatatttctg acattagtaa gattaaaggc aacaatacga
    11341 taatcgaaag gaagttttat tatgacaagg aaagtagcag tagttggaat ggggcacgtt
    11401 ggcgcaactg tcgcccatta tctcgttgct ggtggattca ctgattattt agccctctat
    11461 gatactaacg aagcaaaggt ccgtgccgat gcgcttgacc tccgtgacgc catggcgaat
    11521 ctcccgttcc acacaaactt aaccgttaat gatgattcac aattagctga ctgtgacgtt
    11581 gtaatctcta ctctgggaaa gtctaagctg gtggacacac ccgatcacga ccgctttgca
    11641 gaatttaaat ttacccggac tcaggttcca ttggtcgcta agaaactcgt cgataacggt
    11701 tttcatggca aacttgtcga cgttaccaat ccctgtgacg tcatcacttc aatgtatcag
    11761 aagctcacgg ggctaccaaa gaatcacgtg atgggtacgg ggaccctgct agactccgca
    11821 cgaatgcgcg catgcgttgg ggaagccctc catgttgact cacgatccgt ggtcggcttc
    11881 aatcttggtg aacacggtaa ctcccaattt actgcctggt caacagtccg ggttctcggc
    11941 aaacgagtac tagatctggt ggatgaacgg cacctcgacc ttaccgacat ggaagaacgc
    12001 gcacggcaag gaggctacat ggtctataag ggaaagaagt ataccaacta cggtgttgct
    12061 actgccgcag tccggcttac caatgcccta ctaagtgatg cccggactga aatgccagtt
    12121 tcaaattacc gtgaagaata cggaacgtac ctctcctacc ccgcagtcgt tggtcgtgac
    12181 ggggtggtgg aacaacttca cctggacctt accgctgctg aaaaagaaaa gctcgctacc
    12241 tctgccaaat acatcaagga tcgccttgct gcagaagaac aacgggcagc tcaacaagac
    12301 gcctaacttg ctggtattaa atgatctctc ctcaaacata tccctaataa agcaccaacc
    12361 ttattttgta taactgaaac ttgaaagctg ataaccatgt caaacaggcg aggttatcag
    12421 ctttcaagtt tcagttaatt aatcaacggc ggagccagct taaatagctg gcttttatta
    12481 tgcagaaagg aggtaaaaat agctaaagtt caaaacgaaa tggcgacccg gatcactgtt
    12541 gatactgtcc aggcggctaa ttccatgcag gcaatgcgtc aggctatctc agccaatacg
    12601 aatgcatgga aggcaattaa aaatcaacca ttctgtgaca gaatattaag tagtactggg
    12661 gagtgaataa agatggtgat cgacacacat actgaaatat atgacctcct aagggaatat
    12721 gaacggactt gtgtgaccat tacgtttaaa gacggaacgt ccaagaagat tttctttctg
    12781 gatgttgacg atgaatacca agaaaatgat gtgagacctg aaaaagattg tatcgtatac
    12841 aatataacgg attcgatatc atatggtaat ggcatcccgc tagataaact taagtccatt
    12901 gaaacaatta agcactagcg ttggctggtg ttttttctta accggcataa atacgtatcc
    12961 tcccaagtta gtaaacaccc tgataaaacc acttgttatt tttgaaagcg ttttctataa
    13021 tagttatgta atttatatca caagcaaagg agacgtaaat tatgaagatt aaagctgcgg
    13081 tggttgaaga acaaggtgcg ccatttacca ttaaggacga tgttgaactg gctgagattg
    13141 gtcccctgtc aataaaatag acaatttaaa tagagacttt tttgtcctat gccacgacta
    13201 aattttgaat ttgagtttga
//
