LOCUS       c00162_gnlPro..        11020 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EFBBDKOM_180.
ACCESSION   c00162_gnlPro..
VERSION     c00162_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 10:57:38
            Original ID  :: gnl|Prokka|EFBBDKOM_180
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11020
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11020
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[27:4640]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      28..4640
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..11020
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11020
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             28..444
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg162_1"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.5e-26, bitscore:
                     82.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVAGALAEVEEKGIRL
                     IDKAPRKGAEGLNIAFLHPKSTLGVLTELCEKPE"
     CDS             503..2056
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg162_2"
                     /sec_met_domain="CT_Btheta (E-value: 9.4e-292, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             2088..3020
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg162_3"
                     /sec_met_domain="OAD_gamma (E-value: 7.6e-18, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             3044..3478
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg162_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.9e-22, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             3480..4640
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg162_5"
                     /sec_met_domain="OAD_beta (E-value: 3.5e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             4810..6162
                     /locus_tag="ctg162_6"
                     /transl_table=11
                     /translation="MRKLFISLCFSACCSLLAAQTTNPIQEAMANYDYETALMLIDQET
                     PTVPLLYQKGKALKGLGNNLEALSVFQEVVARDSLNPRAYIEAAECCKSLAKYSEALDY
                     YQNALHINPDNKYARIQYISLLMNMKRYRESLKESNLLAERDSSAYVLHLRAESMGQVY
                     DNTEIMHVIDAYLDIQKRYPNDYLSAAKLGNIYVAGHQYEDAISITEKYRSIDSTNVLV
                     NRINAQAYCLNKDYPKAIERYEQLLQEKDSSFQTCFYAGISYYALEDFYPAHDLLERAL
                     KDDNTNINVLYYLGRACSKTSWKEDGVTYLETAVSLAMPSDSVMSRLYVGLADCYKMAF
                     QYTDQANTLLTQYEKYDRQKHKLLYDAAFIYYYYLKDVSKAERYLTAYLKTRPKNSKDK
                     VQEVDADGVPIIGEDNRYNAAENWLKDIREKRKKEDFFKGKVDTASVTPIK"
     CDS             6272..8122
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg162_7"
                     /sec_met_domain="Alpha-amylase (E-value: 2.1e-64, bitscore:
                     207.4, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVFLILGTLLLSLSTYAAMNVNKIDPPFWYTGMQNPELQLMVY
                     GEGIGNAAVSVNYPGVSLSSTVKLESNNYLLVYLKLDKDVKPGKFNLTFTEGKKKLVKE
                     YELKARNKKGCEHKGFDASDALYLLMPDRFANGNPDNDQIAGMADYKVDRNDPNARHGG
                     DLAGIEQHLDYFSDLGVTALWFTPVLENNMTGGSYHGYATTDYYKVDPRFGTNEEYKQL
                     IEKAHARGIKIVMDMIFNHCGVEHVWIKDMPSKDWFNNPDHENNFVQTSFKLTPHVDPY
                     TSQYDADQMNNGWFVPSMPDLNQKNPHVYRYLVQNSFWWIEFANIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPKNSNLKTVMDFSFFDKI
                     NTAKNEQTETWFKGLDRIYNNFVYDFLYPNPASVLAFIENHDTDRFLGEGDNLPMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTGDATNALTPAGRTKIQNE
                     CYDFYKTILNWRKGNDVIAKGSMVQFMVQNGVYAYARQYEGKTIFVMLNGTDAETTVPL
                     KFYKEILKNSKQGKDILSGKAITFGEELKMGPRESLVIEL"
     CDS             complement(8593..9603)
                     /locus_tag="ctg162_8"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVDYAHQFDVTVEGELGVLAGVEDEVSAEHHT
                     YTNPEEVIDFATRTGCDSLAISIGTSHGAYKFKPEQCHVDPATGRLVPPPLEFAVLDAV
                     MEKLPGFPIVLHGSSSVPQEEVDTINKYGGKLEAAIGIPEEQLRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSENKLAQLD"
     CDS             complement(9886..10893)
                     /locus_tag="ctg162_9"
                     /transl_table=11
                     /translation="MRKLLVLCSFWLCVATLGAQNAERKLYSVAFYNLENLFDTIHDAG
                     KNDYEFLPDGSYQWTAKKYESKLQNLSKVLGSLSRDLVPEGPAFIGVAEAENSRVLEDL
                     VKQPAISNYEFVHYEGPDRRGIDCALLYDPKQFSVTHSKLVLSTPFEGDTVHLTRGFLI
                     VDGQLAGERVCVIVNHWPSRGAKSPVRVHAARQVKALKDSLMRSDKKLKLIVMGDMNDD
                     PMDESMEVLGARKYPKQVKKGEFYNPWWETLEDKGVGTLLYRGKWNLFDQIVISKPLLK
                     AKKGLRYDHNEVFIRDYLIQQDGKYKGSPLRTHGGRTWLNGYSDHLPTIIYLKN"
ORIGIN
        1 acaatactaa cattaattta tatagttatg aagatttcac acattgagca tctgggcatt
       61 gccgttaaga gcattgaaga agcccttccg tactacgaaa acgttttagg tttgaaatgc
      121 tacaacatcg aaaccgtgga agatcagaaa gttagaaccg ctttcctgaa agtgggcgat
      181 gtaaagatcg aattgttgga acctacttct cccgaaagca caattgccaa gttcatcgaa
      241 aagaacaacg gtaacggtgg catgcatcat ctcgcattcg ccgttgaaga cggagtggcc
      301 ggtgcgcttg ccgaagtcga agaaaaaggt atccgcctta tagacaaagc tccccgcaaa
      361 ggtgcagaag gtctgaacat tgcattcctg catccgaagt caactctcgg tgtcctgacc
      421 gagctttgcg agaaaccgga ataagcaaga ctgtaaaatc atcaaatcat aaattgtata
      481 aacacttaaa gaatataaat tcatgagtaa tcaacttgaa aagattaaag agcttataga
      541 ccgccgcgct gcagcacgtc tcggtggtgg tgaaaaagcg attgcaaagc aacacgagaa
      601 gggtaaatat acagctcgcg agcgcatagc catgcttctc gacgaaggca gtttcgaaga
      661 aatggacatg ttcgtagaac atagatgcac caacttcggc atggaaaaga aacactaccc
      721 cggtgacggt gtagtaaccg gttgcggtac aatcgaaggc cgtctggttt atatcttcgc
      781 acaggacttc acagtttctg ccggttcact gtccgaaacc atgtctctga aaatctgtaa
      841 gattatggac caagccatga aaatgggtgc tccgtgtatc ggtatcaacg actcgggcgg
      901 tgcacgtatt caggaaggta ttaatgcctt ggctggctac gctgaaatct tccaacgtaa
      961 catacttgct tcgggtgtca ttccgcagat ttccggtatt ttcggtcctt gtgccggtgg
     1021 cgccgtttac tctcctgcct tgacagactt tactttgatg atggaaggta catcctacat
     1081 gttccttacc ggtccgaagg tagtaaagac tgtaaccgga gaagacgtaa gccaggaaaa
     1141 cctgggtggt gcgagcgttc actccaccaa atctggtgtt actcatttta ctgcacagac
     1201 agaagaagaa ggtttggctc ttatccgcaa actgttgagc tacattcccc agaacaacct
     1261 ggaagaagct ccctatgtag actgtacaga ccctatcgac cgtctggaag attccctgaa
     1321 cgacatcatt cctgataacc cgaacaagcc gtacgatatg tacgaggtaa ttggtgctat
     1381 catagataat ggtgagttcc tcgaaatcca aaaagattat tcaaagaata tcattattgg
     1441 tttcgcacgt ttcaacggac agtccgtagg tattgttgcc aaccagccga agtatctggc
     1501 aggtgtgctc gacagcaacg catcccgcaa gggcgcacgc ttcgtccgtt tctgcgacgc
     1561 cttcaatatt cctatcgtat cattggtaga cgtaccggga ttccttccgg gaaccggcca
     1621 ggagtacaac ggcgtcatcc tgcacggtgc caaactgctg tatgcatacg gtgaagctac
     1681 tgtacccaag gttaccatca cactgcgtaa atcctacggt ggttcgcaca tcgtgatgag
     1741 ctgtaagcag ctgcgtggcg acatgaatta tgcttggcct actgctgaaa tcgctgtaat
     1801 gggtggtgca ggtgctgtag aagtattata tgcccgcgaa gccaaagagc aggaaaatcc
     1861 ggctcaattc ctggctgaaa aagaggctga atacaccaag ttgtttgcca atccttataa
     1921 tgcagctaaa tatggctaca ttgatgatgt tatcgaaccg cgtaacacac gtttccgcat
     1981 cattcgtgcc ctgcaacagt tgcaaaccaa gaaattgact aacccggcta agaagcatgg
     2041 taatattccc ttgtaatcaa gcttttcaca ctaaaacaag aacgattatg aataaaacaa
     2101 aaatcggaat attcctttca ttgatgctgg tgttaggctt ttgctcttct tgcaaagaac
     2161 agaaatcgaa caacaaactg ctgctgaatg aagtgctggt caacaacgaa agcaactatc
     2221 aggatgacta cggtgtgcac agcgcatgga ttgaaatatt caacagatca tacggcagcg
     2281 ccgaccttgc aggttgctat ctgaaattca gcagccagcc gggtgatact gccagttatt
     2341 tcattcccaa aggtgacgtt ctgacactca taaaaccacg tcagcatgca cttttctggg
     2401 ctgatggaga accaagacgc ggtacatttc atacgaactt caaactggat gccacaaatg
     2461 ccaactggat tgggttgtat gattccggca agaaattgct tgatcaagtc atagtgcctg
     2521 ccggtacttt aaaagccaac caatcctatg cccgtgtcag tgatgcagcc gaccaatggg
     2581 aagtaaaggg tggaagcgaa gataaatatg tcactccgag taccaacaac aagactatcg
     2641 acagcaatgc caaaatggaa aaattcgaag agcatgacag cgtaggtatc ggtatggcta
     2701 tttctgccat gagcgttgta ttctgcgggc tgatattact ctacatctcc ttcaagatta
     2761 taggtaaaat atcagttaac ctcagcaaac gcaatgccat gaaagctaaa ggtattactg
     2821 ataaacaaga agcaaaagag aaacaactgg ggcaggctcc gggagaagtt tttgctgcca
     2881 tttcaatggc catgcacgaa ttccaaagcg atgtacacga tgtggaagac acgatactta
     2941 ccattacccg tgtaaaacgc agttactcac cgtggagttc aaagatttat acgttgcgtg
     3001 agactcctca caaaaagtaa gtcacccata ataaaataaa acgatgaaag aatataaata
     3061 taaaattaac ggtaacgtat ataaagttgc cattggagat attgaagaca acatcgctca
     3121 tgtagaagtg aacggtactc cctacaaagt tgaaatggaa aaagcaccga aggtagtcgt
     3181 taaaccggta gcacgtccgg cagccacatc cgctcctgct gctcctgcta ctccggtagt
     3241 aaaaccggcc gctgcttcta ccggcaagtc aggtgtaaaa tctccgcttc ccggtgtaat
     3301 cctcgatatc aaagtaaatg tcggcgatac agtaaagaag ggacaagtta tcatcatttt
     3361 ggaagccatg aagatggaaa acaatatcaa tgctgataaa gacggtaaga ttacagccat
     3421 caatgtaaac aaaggggact ctgttctcga aggtactgac ctcgtaatta ttgaataata
     3481 tgggagaatt tatcacattt ttaggaaaca accttgccga cttctggact tatacaggtt
     3541 ttgccaatgc aacggtagga catgtggtaa tgcttctggt aggtttgttt ttcatatact
     3601 tggctgtagc caaggaattt gagccgatgc tattaattcc tatcggtttc ggtatgctga
     3661 ttggtaatat acctttcaat atggaagccg gattgaaagt tggtatctat gaagaaggtt
     3721 ccgtacttaa tattctgtac cagggagtaa cctccggttg gtacccgcca ctcatattcc
     3781 tgggtatcgg tgccatgacg gatttctctg ctttgatatc gaaccccaaa ttaatgttgg
     3841 ttggtgcagc agcccaattc ggtatattcg gtgcttatat gattgccctt gccataggat
     3901 ttgacccgat gcaggctggt gcaatcggta tcattggtgg tgccgatggt ccgactgcca
     3961 tcttcctctc ttctaaactg gctcctaact taatgggtgc cattgcggta tcagcctatt
     4021 catatatggc attagtaccg gtgatacagc cgcctattat gcgttggctg accagtaaaa
     4081 atgaacgtct tatccgtatg aaacctcccc gtgtggtttc acatacggaa aaagtaatgt
     4141 tcccgattat cggtttgtta ctgaccacat tccttgtacc atccggtctg cctttgctgg
     4201 gtatgctgtt cttcggtaat ttactgaaag aaagtggagt cacacgtcgt ctggcaaaca
     4261 cagccagtgg tccgctgatt gataccatta ctattctgct tggtttgaca gtaggtgctt
     4321 ctacgcaagc atccgagttc ttaacccttg attcaatcaa gatattcggt ctgggcgcct
     4381 tatcatttgt cattgccaca gcatccggtg tcatcttcgt gaagattttc aacctcttcc
     4441 tgaagaaagg caacaagatt aatccgttga tcggtaatgc cggtgtatct gccgtacccg
     4501 actctgcacg tatctcccaa gtagtaggtc tggaatacga tcctaccaac tatctgctga
     4561 tgcatgccat gggcccgaac gttgccggtg taatcggttc cgctgtagca gcaggtatcc
     4621 tgctgggatt cttaatgtaa tacatttatt cattccgtta tccggcttga attctgaact
     4681 attttagagc cccttcattt ttggaggggc tttttcgtta atctatctaa aacagattac
     4741 gattatttcg taaatacatt ctttttagta acttgcagtc agtttaacct catataaatg
     4801 atatactgta tgcgaaagct ttttatctcc ttatgtttca gtgcatgctg ttcgcttctg
     4861 gcggcacaga ccacaaatcc cattcaagag gcgatggcca actacgatta tgaaacagcc
     4921 ttgatgctga tcgatcaaga aaccccgacc gtccccctac tctaccaaaa agggaaagcg
     4981 ctgaaagggc tgggcaataa ccttgaagct ctgagcgtat ttcaggaagt cgtagctcgg
     5041 gattctctca atccccgggc atacattgaa gctgccgaat gctgcaaatc acttgccaaa
     5101 tatagcgagg cactggatta ctaccaaaat gcgctccaca taaatccgga caataaatac
     5161 gcacgcatcc agtatatcag tctgctgatg aacatgaaga gataccgtga gtctctaaag
     5221 gaaagtaacc tgctggcaga aagggacagt tccgcctatg tactacacct tagagccgaa
     5281 agtatggggc aagtctatga caacacagaa atcatgcatg tgatagatgc ctatctggac
     5341 atacagaaaa gatatcccaa tgattacctg tctgctgcca aactcggcaa catctatgta
     5401 gcaggccacc agtatgaaga cgccataagc ataacggaga aataccgttc catagactcc
     5461 accaacgtcc ttgtgaaccg catcaatgcc caagcctatt gcctgaacaa agattacccc
     5521 aaagcaatag aaagatatga acaactgtta caggaaaaag acagttcttt ccaaacctgc
     5581 ttctacgccg gaatcagcta ttatgccctc gaagacttct acccagcaca cgacctgctg
     5641 gaaagggctc ttaaagatga caataccaac atcaacgttc tctattatct gggacgcgcc
     5701 tgctccaaga catcatggaa agaggatgga gtgacttatc tggaaactgc cgtaagcctc
     5761 gccatgccca gcgacagtgt catgtcccgc ctatatgtgg ggcttgcgga ctgctacaag
     5821 atggcatttc aatacaccga ccaggcgaat acccttctga cgcaatacga aaaatacgac
     5881 cggcagaaac acaaactgct ctacgacgca gcctttatct attattacta tctgaaagat
     5941 gtgtccaaag cagagagata tctgacggca tacctgaaaa cccgtccgaa aaacagcaag
     6001 gacaaagtgc aggaagtaga tgcggacgga gttcccatca tcggagaaga caaccgatac
     6061 aatgccgccg aaaactggct gaaggacatc agggaaaagc gcaagaaaga ggacttcttc
     6121 aagggaaagg tcgataccgc cagcgtaacc cccatcaaat agcccaatga aaacgtttgc
     6181 ataatataat aaggtacagt aacggagaaa gattaacttt ctccgttatt tgttttaaat
     6241 tagcgcaaaa attaaccgta aagttactat catgaaaaaa gtattcttaa tcttgggaac
     6301 actcttactc tccctcagta cgtatgcagc tatgaatgtg aacaaaatcg accctccgtt
     6361 ttggtacacc ggcatgcaga acccggaact ccagctgatg gtctatggcg aaggcatcgg
     6421 caacgcggca gtatccgtca attatcctgg cgtctcattg agtagcaccg tcaagctgga
     6481 aagcaacaac tacctcctgg tctatctgaa actggacaag gatgtaaaac ccggcaaatt
     6541 caacctcacc ttcactgaag gaaaaaagaa actcgtaaag gaatatgaac tgaaggcacg
     6601 caacaagaaa ggttgcgaac ataaaggttt cgacgcctcc gacgcactgt acctgctgat
     6661 gcccgaccgc tttgccaatg gcaacccgga caatgaccag attgcgggca tggccgatta
     6721 caaggtagac cgcaatgacc ccaatgcacg ccacggcggt gaccttgccg gcatcgaaca
     6781 acatctggac tacttctccg acctcggcgt cacagccctc tggtttactc cagtcctgga
     6841 aaacaacatg accggtggtt cctatcacgg ctatgccacc acagactact acaaggtgga
     6901 cccgcgcttc ggtaccaacg aagaatacaa gcagctgatt gaaaaagccc atgcacgcgg
     6961 catcaaaatc gtaatggaca tgattttcaa ccactgcggt gtagagcatg tatggattaa
     7021 ggacatgccc tccaaagact ggttcaacaa ccccgaccac gaaaacaact tcgtgcagac
     7081 ttccttcaaa ctgaccccgc acgtagaccc ttatacttcc cagtacgatg ccgaccagat
     7141 gaacaacggc tggttcgtac cttccatgcc cgacctcaac cagaagaacc ctcacgttta
     7201 ccgctacctg gtacagaaca gtttctggtg gattgaattc gccaacatcg acggcatccg
     7261 catggacact tacccgtatg ccgactatga tgccatgagc aactggatga aagagctcaa
     7321 cgaagaatat cccaactaca acaccgtggg cgagacctgg gttaccgaac ccgcctacac
     7381 cgcctggtgg cagaaggatt ccaagctatc agcccccaag aacagtaacc tcaagaccgt
     7441 tatggacttc agcttcttcg acaagataaa taccgccaag aatgaacaga ccgaaacttg
     7501 gttcaaggga ctggaccgca tatacaataa cttcgtatac gacttcctct accccaaccc
     7561 cgcttccgta ctggcattca tcgaaaacca cgacaccgac cgcttcctgg gcgaaggcga
     7621 caaccttccg atgctgaagc aagcctctac cctgctgctt accacccgcc gcattccgca
     7681 actctactac ggaacggaag ttatgatgaa tggcgtgaag agcaagagcg acggctatgt
     7741 ccgcaaggac ttccccggtg gatggaccgg tgacgcaaca aacgcactga ccccagccgg
     7801 acgtaccaaa atacagaacg agtgctacga cttctacaag accatcctga actggcgcaa
     7861 aggaaacgat gtgattgcca aaggcagcat ggtgcagttc atggtacaga atggtgttta
     7921 tgcctacgca cgccagtacg aaggcaagac gatattcgtg atgctgaacg gtacagatgc
     7981 agagaccacc gttcctttga aattctacaa ggaaatcctg aaaaacagca agcagggaaa
     8041 agatattctt agcggcaagg ccatcacctt cggtgaagag ctgaagatgg gccccagaga
     8101 atcattagtg atagaattat aacgcgtact ccacacagag agctcattct tgcaaatctc
     8161 ccttgcagat agctggcaga cacttctcct gccagccatc tgcaagggat ttttagtatg
     8221 gaataggtgt cacggggata tgcttttcac cggtctcaaa tatagctaat ctgttagttc
     8281 ataacggtga acactttgtt ccagtataga gaaacaaagt gttcggatat gtagaaacaa
     8341 agtgttctta cgtattggaa cgaagtgttt ttgcatattg gaacgaagtg ttctctttat
     8401 tgaaacaaac tgttcagtta agggaaacag actgttttgt taaaggaaac agactgttgt
     8461 acacgttgaa acatccgctt ctgaaataag cggcgaactt aaccatccca caacaccggc
     8521 ctatatacaa caagtcagcc cttgcaatat tgatgttgca agggctgacg ctatattcgg
     8581 attatctttc gattagtcca gttgagccaa tttgttctct gaaccaagca cgttgatgat
     8641 tttatgcttg tacagttttt ccatattgtc acgagccgga cccagatact tacgcgggtc
     8701 gaattctgcc ggtttttcag caaatgtctt gcggatagca gctgtcatag ccagacgtga
     8761 gtcagagtcg atgttgattt tgcaaacagc agacttggca gccttacgca actgctcttc
     8821 ggggataccg atagcagctt ccagcttacc accatacttg ttgatagtat caacttcttc
     8881 ctgaggaact gaagaagaac cgtgaagaac gatggggaat cccggaagtt tctccattac
     8941 agcatccaga acggcaaatt ccaaaggagg aggaaccaga cgaccggtag cagggtcaac
     9001 gtggcattgt tcgggtttga acttgtatgc accgtgagaa gtaccgattg agatagccag
     9061 tgaatcgcaa cctgtacggg tagcgaagtc aataacttct tcaggattag tatatgtatg
     9121 gtgttctgca gaaacttcat cttctacacc ggccaataca ccgagttcgc cttctacagt
     9181 tacgtcgaac tgatgggcat agtcaactac cttcttagtc agtgcaacgt tttcttcgta
     9241 cggaaggtgt gaaccgtcaa tcattactga agagaaaccg gagtcgatac agctcttgca
     9301 agtttcgaat gtatctccgt ggtcaaggtg aagaacaatt tcaggatgtt tgcaacccaa
     9361 ttccttagcg tactcaacag caccctgagc catgtaacgc aacagcgtag cgttggcata
     9421 ctgacgggca cccttagata cctgaagaat aaccggagac tttgtttcaa ctgcagcctt
     9481 gatgatagcc tgcatctgtt ccatattgtt gaagttgaat gccggaatag catatccacc
     9541 tttgatagcc ttagcaaaca tctctcttgt gtttaccagt cctaaatctt tgtaattaac
     9601 cattttgttt aaattttatt gttagtgaat taaaattcta cgcaaaagta atcattatcc
     9661 tttaaagtaa agaacttgag aggaataaaa tatccggctc atcctaccaa atccattcta
     9721 ttttaaagct attggcttca tttaacagat tattgtaatc tctatattac aaactctttg
     9781 catttatctc tgccaaccat acttttgcca tctatacttc tatcaacaaa aaagccggag
     9841 aacatgtttg ctctccggca tctgtttaca cattattatg taatactaat ttttcagata
     9901 gatgatggtc ggcaaatggt cactgtaacc gttcagccaa gtcctgcccc catgcgtacg
     9961 caagggggaa cctttgtatt tgccatcctg ctgaatcaga taatcgcgga tgaaaacttc
    10021 attgtgatca tagcgcaacc ctttcttagc cttcagcaac ggtttcgaaa tgacaatctg
    10081 gtcaaacaag ttccacttgc cccgatagag caatgtcccc actcccttgt cttccagtgt
    10141 ctcccaccag ggattgtaga attcgccttt cttcacctgc ttcggatatt tgcgtgcacc
    10201 cagcacctcc atgctttcat ccatcgggtc gtcattcata tcccccatca cgatgagttt
    10261 cagcttcttg tcgctacgca tcagagagtc cttcaaggcc tttacctgcc tggctgcatg
    10321 cacacgcacc ggtgactttg ccccacggga gggccagtgg ttcactatca cgcagacacg
    10381 ctctcccgcc agttgtccgt ccacaatcag gaagccgcgc gtcaagtgca ccgtatcccc
    10441 ctcaaaagga gtagaaagca ccaactttga gtgggtaacg ctgaactgct tcgggtcgta
    10501 cagcaaggca cagtcgatgc cccgtctgtc cggtccttca taatgcacga actcataatt
    10561 ggaaatggcc ggctgcttca cgaggtcttc cagcacccgg ctgttctccg cctctgccac
    10621 accgatgaat gccggacctt ccggcactaa atcacgcgaa agggaaccca acactttgga
    10681 aaggttctgc agcttggact catacttctt tgccgtccat tggtaactgc cgtcgggcag
    10741 gaactcatag tcattcttac ctgcatcatg aatcgtatca aacaagttct caagattgta
    10801 gaacgcaaca ctatacagtt tccgttccgc attttgtgcc cccagcgttg ccacgcacag
    10861 ccagaaagag cataagacaa gtagtttcct cataaattca caagattaag tcctgcaaaa
    10921 atcagaaata aaatgcgata aacctactaa ataaaaataa atctgaattt attttgtaga
    10981 gtctccaact tgcactatct ttgcgctctg aaaagaagac
//
