LOCUS       gnlProkkaHLHHGGLG_159  14484 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HLHHGGLG_159.
ACCESSION   gnlProkkaHLHHGGLG_159
VERSION     gnlProkkaHLHHGGLG_159
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:30:06
            Original ID  :: gnl|Prokka|HLHHGGLG_159
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14484
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14484
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4133:4484]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4134..4484
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14484
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14484
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             979..2490
                     /locus_tag="ctg145_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             2563..3630
                     /locus_tag="ctg145_2"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELTSVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPTVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             3667..3951
                     /locus_tag="ctg145_3"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLTRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(4134..4484)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg145_4"
                     /sec_met_domain="PqqD_RRE (E-value: 1.3e-10, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.8e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(4582..5970)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 95.3; E-value: 4.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg145_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGYTDEGGAFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSLMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(6218..6634)
                     /locus_tag="ctg145_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPATETPAPAAE"
     CDS             complement(6641..7414)
                     /locus_tag="ctg145_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(7420..7947)
                     /locus_tag="ctg145_8"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7934..9175)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg145_9"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(9185..10279)
                     /locus_tag="ctg145_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(10284..11324)
                     /locus_tag="ctg145_11"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGEASKE
                     AEQTNK"
     CDS             complement(11343..12353)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_12"
                     /sec_met_domain="PF04055 (E-value: 2.4e-17, bitscore: 57.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
ORIGIN
        1 aagaccaaga aaaagactgg gatttttatc accgaaagag gcacaaactt ttagaaaaat
       61 taagcaactc aagaaaaaat tgaaattata aaataaggag gggtcgcatt tacaacttga
      121 attcagccta cagaaaaaga tttttcattt tcatttctca tatcctcata aataaggcac
      181 aagtggcagt aaactaataa gatagactat gagaaatgat tttaaaacag gcatttctca
      241 tagtttcttc gcaaaataac ccggattttg cttcatttct catagtgtag tgtgccggaa
      301 gctgacattg aataaataga actatgtatt ccttttgctt gcttccatac acagtgtctt
      361 agtcccacat attgtgggaa aagattccct aaggcttggg aaagtattcc cttattttgt
      421 gggaaagttt tccttcaata tacgagaata ctttcccaca atatatggga caatcgagaa
      481 caacgagcat ctccaagcaa aaagccacta ttttatctaa atagtagctt catttcctga
      541 taaaaataag gcaggctgaa agaaaaaagg aagaaagaat ggcttttgac tatgagaaat
      601 accctgaaat acgatgagaa taaggtggct tttgagccaa aacatgggag aacttatgag
      661 aaataccgtt ttgaaaaagt gtttctcata agatatctat ttgattatct ttcgtttatc
      721 gaaaaacaat gagaatatga gaaatgaaga aatctttttc agggagaaat aaaagtaagt
      781 tcataatggt gcagcattga attatttttt ggcggagtta ttctaacact taatagttca
      841 aaagcagata tttctttgac caaaagatag aactaatgat gaattaaaag ttgcaattat
      901 ggttttcttc ccacaacaaa cgggaaaagt cagaagaatc atgtacattt gtaatccgaa
      961 aactaaaaga acatcgcaat gaaaatattt ccaagcagca gtatcaagaa attggacgct
     1021 tataccattg agaacgaacc tattgcatca atcgatctga tggaacgtgc agcaaccgta
     1081 ttaacaaaag ccatcacaga cagatggaat acggaaacgc cggtcactat ctttgccgga
     1141 ccggggaata atggcggaga cgctctcgcc gtagcccgca tgatggctga aaaaggatat
     1201 aaaatcgagg tatttctctt caacacgaaa ggagaacttt cacccgactg ccagaccaat
     1261 aaagaactgg tagaaatgat ggaagaagta aaattccacg aaatcagtac ccaattcgta
     1321 cctcccgtcc tgacgcccga tcatctggta atcgacggat tattcggttc aggtctgaac
     1381 aaaccgttga gcggtggatt cgctgccgta gtgaaataca tcaattcctc ccctgccatg
     1441 gtagtagcca tcgacattcc ttccggactg atgggagaag aaaatacatt caacgtaaaa
     1501 gctaatatta tccgcgccga cgtaactttc agtctgcaac tgccgaagct cgcctttctt
     1561 ttcgcagaga acactgaatt tgtcggagaa tgggaagtgc tggatatcca attaagcgaa
     1621 gacggtattg aagagatgga gactaactac gaaatgttgg aaatagaaga aatccgttca
     1681 ctcatcaagc cacgcaaaca gtttgcccac aaggggaact tcggccatgc actattgatt
     1741 gccggttcaa aaggaatggc aggagcctct gttctcgctg cccgcgcctg cctccgttcg
     1801 ggagtagggt tgctgactgt tcatgcacca atgtgcaaca acgacatctt gcagacctcc
     1861 atacccgaag caatcgtaga aaccgacatc aacgaaacct gttttgccgt acctaccgat
     1921 acggacgact accaagcagt cggcatcggc ccgggactgg gacgaaacga ggaaacggaa
     1981 gctgccttgt tggagcaact ggaacactgc cagactcctg ttgtagtgga tgccgacgct
     2041 cttaatatcc tcgccaacca ccgccatacc cttacccacc tgccgaaggg ttccatcctc
     2101 accccgcatc cgaaagaact ggaacgtctg accggcaaat gccaggactc ttacgaacgt
     2161 ctgatgaagg cttgcgaact ggcccgtgcc gcccatgtcc acattatttt aaaaggagcc
     2221 tactccgcca ttatcacccc agaaggtaaa tgtttcttca acccaaccgg aaatccggga
     2281 atggcaaccg gaggtagcgg tgacgtactg accggagtaa tcctggcgct gcttgcccaa
     2341 ggttatccca ccgaagaagc cgctaaaatc ggcacttaca ttcacggatt ggcgggcgat
     2401 gtcgctcaaa agaagcaagg aatgatcgga atgatcgcaa gcgatattat cacctgtctg
     2461 ccgacagcat ggcgacttgt aagcgaataa aagttaagaa cttacagttt tttcaataac
     2521 ttcattaact ttgttttcaa aaccagttaa aaagaaccga atatgaaaaa gttgattata
     2581 gcagcaggac tacttatgac aacgtccgcc tatgcacaaa ccgaagtact gacaggggtt
     2641 acccgaggaa aagactatgg agtggtttac agtcttccca aaacccaaat agaacttgaa
     2701 ataaaagcca acaaagtcaa ctatactccg ggagaattca gcaaatatgc tgatcgttac
     2761 ctgcgactga ccaacgtctc cgccgaccct gaagagtact gggaactgac tagcgtaaaa
     2821 gtgaaatccg taggtgtgcc caacagcgaa acgacgtatt tcgtaaaatt gaaggataag
     2881 acagtagcac cgctcatgga actgacagag gatggcattg tgaaaacgat caatgttcct
     2941 tacagcaaca gcagtgtagg caaaaaagcc gctcccgctc ccacagtcct ccaaaagaaa
     3001 gcaaatcctc gtgaattcct gaccgaagag attctgatgg ctagctctac cgccaagatg
     3061 gccgaactgg tggctaaaga aatctataac atccgcgaaa gcaaaaatgc cttattgcgc
     3121 ggacaggctg acaatatgcc ttcagacgga gcacagctta agattatgct cgacaatctg
     3181 aatgcacagg aagaagccat gacgcaaatg ttctccggca cctgcaacaa ggaagagaga
     3241 acattcactg tccgccttac ccctgacaag gaatttaaca atgaagttgc tttccgcttc
     3301 tcgaagaagt taggtgtagt tgccaacaat gatttggcag gaactccgtt ttatatcagt
     3361 ctgaaagacc tgaaatcggt caagatacca caggaagatg gtaagaagaa gaaagatttg
     3421 gatggaatcg cctacaacgt acccggacaa gctatggtta cattgaccga cggcaaaaag
     3481 aaactttacg aaggtgaact tcctattact caatttggtg tgatagaata tctggctccg
     3541 gttttgttca acaagaattc taccatcaaa gtttattttg atccgaatac gggaggattg
     3601 ctcaaagtgg acagagaaga agggaaatag aaaaacgaga aagtgaactt ctaaaaaaca
     3661 aagaatatgg ttggtgaagg acatgcattc gacatgatac gccgaataaa agagggacgg
     3721 gaagcttccc gcctacgtcg tgaacgtgct aacgacaagt tgaagcattt aacccgtgca
     3781 aacgaacctt atccactacc caataccact cccgaagaaa tggaacgtat catccacgac
     3841 tcggagaaaa agaaagagaa agacagcaat tattttgttt ggggaacgct tattatcatg
     3901 ggagtcctga tagcaattgc cgtcatactt tgggctgtat ttatcaaata aataataata
     3961 aattcaccac agaggacacg gaggacacag aggtttaatc ttttttattc actatagagt
     4021 aacacagagt ctcacgtatt gagaatcgta tttatcgctc tgttttactt gcggaaagag
     4081 agagaagaac tctgtgtcct ccgtgtcctc tgtggtgaaa tataaattcc tatttatgcg
     4141 actggtatca ccagttttat aaatccatct ttctgcattt gagaaagata agccgataca
     4201 cgcgactcgt agccctcttc attttgaaaa tggtctgcga gtttttctat aatctcacga
     4261 acattgcgtt ttccatctat cagttcccat acagccgtac cgtgttcttc caatttcaca
     4321 tgaagttctt tcgacattcc tttcggcaca aggaagcgtt gcatccacgg atatttaaaa
     4381 cggggaaagg agagcacaat tgtctcccct tccctttctg ctgtaatatg ttcactgcga
     4441 cagggaatga cctctaacag gttgattttc tctttggcag ccatacttct tattttttat
     4501 ttcagagtat tcatactgat acccttttgt ttacaccttg atacaaaatt cctttgttac
     4561 tttaggtatt gaatttccca gttacttttg gatattcgcc tcttccagac cgtatccctt
     4621 cttcttgttc tctgccttca acatcaaagc cacaatcaga gcaagtacac caaagagagc
     4681 aaaaatagtc atcggcaatg tgtaatcata agtctgtgca ccgtctacca ccggaccttt
     4741 gcaataagta ttcaataccc atccgattaa caaaggaaca cccatcagtc cccagttctg
     4801 tacccagaaa atcaaagcgt aagcagtacc cagctgtttt tccggaataa tcttcggaac
     4861 agaaggccac atagccgaag gcaccaatga gaaagcaaat cccaatataa tcattataat
     4921 agtagcaaac caccatatat tcagtatagg cagggcaaac atggtatgta caaaaattag
     4981 catcaatgat ccgatcacca tcaatgtggc tcctttaccg atacggtcat ataacgaacc
     5041 gaacaacgga gtcaggataa ttgcaccaat cggcaacaat ccgggaatcg ttcccgccag
     5101 tttcggatct acattatatt tctgcaccat caagtcggca gcatatttga taaaagggaa
     5161 gacggccgag tagaacaata cgcacagcaa tgcgatcaac cagaatccct tattggtaat
     5221 gatatacaca atatctttca tacggaacgg ttcttccggt tccaaacctt ctgcatccaa
     5281 agaagcatcc aatttcttat cgtagaaagt ataaaggaag aaagcaatag tacctacaca
     5341 cagcataatc agacaaaaca gaataggagc aggaatattg gtatggaatg caccaccctc
     5401 gtccgtatat ccgaagaagt ctgccaaagg aactgtcaac accatcgcca gagttgtccc
     5461 aatacgtgcc gtagccattt caagtcccat agccaatgcc atttccttgc ccttgaacca
     5521 tttcactata atcttggaaa cagtgatacc agcaatctcc acacctacac caaagatagc
     5581 atatcccaat gcagccaacg tcacctgtgt tttgaatccg aagagcatgg caccttccgg
     5641 aaaagtagta gaaatcgcat agtatttcaa tccacaacca aacaccatca ataagcaagc
     5701 tcccattccg gtgaaacgaa ctcccatttt gtccaaaatg ataccaccga agatcagcat
     5761 caacaagaat acgttaaacc aaccgtaagc gcttgtgaag aatccataat caagactatc
     5821 ccataatagt tctttctcaa gcatgggttt tagaggagac attacgtcgg tgaggaaata
     5881 gccgcatagc atagtaaatg cgaccaatgc tagaacactc catcggagta cggcggagtc
     5941 attcaatttc tgtttcaaat gttctgtcat tgttatattt aaaaaagtag ttaataatct
     6001 tatacagcca acaaaggtag ttaaatctcg tttgtttcta tcacaaagag attgttttta
     6061 caagaaaaag ttaagtgcgg attacactga ccactcggaa cattgaaaat ccgtgtaatc
     6121 tgcgtaatcc gcacttaaat atcaaagaaa tgcagcatcc gtctgcacct tcccattaat
     6181 ggttttaccc caaagtctta cctgacgacg gagtgaatta ctctgctgca ggagcaggag
     6241 tttcagtagc cggtgccgga gtttctgtag caggtgccgg agtttctgta gcaggtgcat
     6301 tggtagcagg agcttcagtt tgcggcgcag ccgtacctgc gggtaagtta tacgggttag
     6361 tctgttgttc tttctgtgcc tgttccaaca ctgcgtcttt agcaacagca gagcgaggaa
     6421 ctacataagc agtagcaatg ctcattacaa ccataaagat ggccaggccc catgttgctt
     6481 tttccagaaa gtctgtagtc ttgcgcacgc ccatgatggc gttagatgaa gagaaaccag
     6541 aagcaagtcc gcctcctttt gagttctgaa tcagcacgat gaaacacatc aacaaggctg
     6601 caataaccat taagataacg aataataagt acatttttag ttattttgaa ttagcgttaa
     6661 taatcaattt ctccaaaaat ctgatttggt ctgcaaagta agcatttttt tttggatatt
     6721 tcaagcttaa ttttttaatt atttcaagag cttttgaata tcgttgctgt ttaacataga
     6781 tttttgccaa agtttccgta aaacagctgt catcttcctc ttcttccttc atcgtttctt
     6841 cttcggtaag ttcgtccgaa gaggttggcg aagatggcat ttcttctctt aaaggtttca
     6901 tgcagagggg agagtcgctc tcgctctttt ctataaaatc gtcaatcagt tcgaagcctt
     6961 tgagtttggg cgtttcttca gccggctgtt ccgtggccgg agtctcctcc aaaaggaaag
     7021 aggtgtaatc catcgaatag tcgaaactgg tccgagcagt cacctcttcg ggtactgtgg
     7081 acaagaaagc gtcgatcaat gctaatgtgc ggtctacgga cggttcgtct ttcagcacct
     7141 ccgtgagagg tactcccttt ttccgtgcct gcacatcata gcggtcacct tcaatcaacc
     7201 ggaacaactg ccgtctgtct gcaatgtaaa gaactgcttt ccgcagttct ccaccgaaac
     7261 taatatcatg gagaatatac agattcttca gatacaacag acgaagtgac tgaaaatacg
     7321 gatacctcgc aagaagattg cgcagttcgt acaaagtatc cctattcagc gtctcgggat
     7381 gctgaatcca ttgttgaaag ttaacagaag tcatttatat taccagtttg ctacagttgc
     7441 attaaaaatt tggtcggtga tctctttaga catttcagca atcaatccgt cctgtacggc
     7501 agtcaacaac tgggtagagt cgtaggtacg gaacgcagaa aactgttgtt caaagtcttc
     7561 ggcatgattg gtgttgttga caaaacgcac attgacggtg atagtcaact tcgtctccga
     7621 agaataaccg tcggcagata ctgcctggtt gtactgattg taccctgtga tttctccgtc
     7681 aatctgcaag tcggcatttt gactcggctt gagcagttgc agacgggtct gccggatgaa
     7741 gatatctttc aggtcctcat tgaatttggt tgccaacgga gcatatacat actccgactt
     7801 gatcgggaag tcggctatcg aaatggtctt taccttatca taattgatag acgatccgtt
     7861 aaacttatag gaaacagtgc acgcaatgac taccaacggc aagccgaaca gtagcaaagg
     7921 gcgtattatt ttcttaatcc aattcatatt cttttatttt tctataaagt gtacgctcgg
     7981 aaatattcaa gtccttggcc gcactcttcc gctttccgtg atgcctttca agtgctttgc
     8041 gtatcatttc tttttccact tcgtccagtg acaaaggagg ttcttctaca tattcttccg
     8101 tgtcttgtat gtcatcgtca tccttgcaaa ccgcaggctg catggtatga atgatcgcag
     8161 gtaccgaagg ctggtgtgtc gtcactaccg gagtagtaac caccgttccc acttgtccta
     8221 cctgccccac ctgtccggca cgttccgcca tcaggttgtg caccatcttc ttcagctccg
     8281 ccacttcctg gcgcatatcg aacagaacag aataaagaat ctcccgttcg ctctcaaagc
     8341 ctttactctc acgcgttccc atcagcgcgg gaagacgttg cgtattttgt gcgggaagat
     8401 aattctgcaa gatagcagca gagatctccc tgttggtttc aatgatagat atttgctcgg
     8461 tgatgttctt caactgacga acgttgccgg gccacgggta agccaataac tctttcttcg
     8521 catcctccgt caactggata gcaggcatcc ggtatttctc tgcaaagtct gcggaaaact
     8581 tacggaacaa caaaagtaca tcgtcaccac gttcacgcaa aggcggtatt tggataggca
     8641 ccgtattcaa ccggtaatat aaatcttcac ggaaacgtcc ttctgcaatc gcttgtgtca
     8701 gattgacatt ggtagctgcc acaatacgaa catccgtctt ttgcactttg gacgaaccta
     8761 cttttataaa ctcgccactc tccaacacac ggagcaaacg cgcctgggta ggcatcggca
     8821 actcccctac ttcatcaagg aaaatagtac caccgtcggc ttcgccaaag taccctttcc
     8881 gttcgccaat cgcaccggta aacgcaccct tctcatgccc gaacagttcg gaatcaatcg
     8941 tgccctccgg aatagcacca cagttgacag caatatactg tccgtgcttc ctccggctat
     9001 attgatgaat aatctgcgga aaactttctt ttccgactcc actttctccg gtaatcagca
     9061 cagacaaatc ggtaggagct acctgaatgg caacatctat ggcgcgcgac aatgcttcag
     9121 tatttccaat aataccgaaa cgctgtttca cttgttgtat ctctgctctc gtcatcactc
     9181 gtttttaatc ttcgtctact gtatccagct tcagtttatc actatcgtca cgtttctcgt
     9241 aatactgttt acgcaacgga ttggcacgag ccactttttc ccgctgacga ttacggaaca
     9301 catcgatggc aacatagatt gcctgacgga aagaatcttc acaagccaat cccttgcctg
     9361 caatatcgta tgccgttcca tgagccggag aagtacgtac taccggcagg cctgccgtat
     9421 agttcacccc gtcttccata gccaaggcct tgaacggagc cagcccctga tcgtgataca
     9481 tcgccaggat accgtcaaaa tgagtataat tgcctgaacc cataaagccg tcggccgcat
     9541 aaggaccgta gcaaaggatt cctttctctt ccatttcttt catggcaggg ataatcactt
     9601 cctgctcttc cattcccaac aaaccaccgt ctccggcatg aggattgaga gagagcaccg
     9661 caatacgcgg agcgccgata ccgaaatcct gtttcagaca acgatggaat atcatcagtt
     9721 tctcctgaat cagttctttg gtaatcgtag tcgcgatctc tctaacaggg atatgtgtcg
     9781 tcaccaaagc cacccggaag tcattcttca tcaaaatcat caatgactta tcaccattgc
     9841 ccagacgttc ttcgatatat tccgtatgtc cggggaagga gaactcttcc gactgaatcg
     9901 tatgtttgtt gatcggagct gttacgataa cgtctatcag cccttcgcga tattcttcga
     9961 tggcacgttc caaagcccca agcgcagctt taccggcttc gggatcgggt ttggaaaatt
    10021 ccactttcac ctcatcatcc gtacagttca ccacgctcaa acggttgtac cccgcttcgg
    10081 tagcagagtt gacaatgctg aaattggtct gtatatccag cgctttgcga tgataagccg
    10141 ctactttcgg tgagccataa atgatcggag tacatagttc caacatcgta gggtcggaaa
    10201 atgtcttaag aatcacctca tagcccaccc cgttaatatc tccttgggtg atacctatcc
    10261 ttatcttgtt atcttccatg tttttattta ttagtttgtt ccgcttcctt agatgcctct
    10321 cccaatggaa tctgattctg ctgaacttca ttcggaagtt tcagtgtata cagagatgct
    10381 tccatctggc gtaccaggtt gcgtttcatt ttatcaggtg aataaacaaa tatttctgct
    10441 gttataattc gttggttttt ctcgtccaga cgagtatgag atacatacgg gccacccata
    10501 aagtcgccct tcatacgcca caggccacgt gcttccattg tgtagctgtt ctgtacattg
    10561 atcggacgga catcggtcag caaactatcg gtcgacatat aaacgccttc cttgaatccg
    10621 gggatattgg ctttcatcac agagtcacgt ttgtgcacaa aatattcttt ggtaaacgta
    10681 tccttgtcag tgtacggata agagtacatc acaaagttac ggtcggcact acctgtgttg
    10741 gtagaagccc agaagaaatc atccccggtc tttgaattag ccagttcggc atccacccag
    10801 atgtcgcatc cgaacaaact gtccactttc tgcgaaatga agttactgtg tttcccttcc
    10861 aggaacgtaa tctgacggtt catttccgca cgggtaaaga agtcgacaat cgtctttttg
    10921 ttctcttcca caaacttctc aaactcttct tcgttcggag cctggatagt caatatcatc
    10981 tgcggattgg catacacgtc cttcgcatat ttgaacgagg ctttcgtata tatatcctgt
    11041 atatctacaa taataatgtt acgtatcaac ttcagcgtag aatcataatc tttcggtgaa
    11101 gtatacataa tccggaaaga aggttccgac tgcggcaaac cgggcatatc agcatcgagc
    11161 gcatcatgta aagcccttcc ggcagcacga tcccaaacac cgtgatctac tacaaccaaa
    11221 agctcgtaag cacgaccact agaggtgtga tttcctttca gaccacaaga tgcaacgaca
    11281 aaggctacca aagcgatgca taaaataaaa gagtactttt tcatgatgtt cggttttata
    11341 tattaacttt cattattttt ctcctgtttc gctgtcgaca gcataccgca agcggcaaaa
    11401 atatcttcgc ccctggatga acggatagtg gtgaaaagtc cgtgtgacgt cagataatca
    11461 cgaaaacggg tcatcgtatc catgtccgct ccctcgaggt ctacccccgg tatggcatga
    11521 aaacgaatca gattcaccct gcaatccagc ccgcgaagaa gtttcagcaa ctctttggca
    11581 tagacctgcg aatcattgag ccctttaaaa acaatatatt caaacgaaag tcgacgttgt
    11641 ttactaaaat catagttttt taacagttcc accatttcgg tgattgaaaa cgccttttcc
    11701 gccggcatta attcagcacg ctgaacggtc agcggagagt gaaggctgat ggcaaggtgg
    11761 cagtcatttt cttcaataaa acgctgcaat cctttccgta gcccgactgt agaaagcgtg
    11821 atacgcttcg gactccatgc gtaaccgtag gtagcggtca gtagttccaa tgccttcaat
    11881 acctcatcca ggttatcgag cggctcgccc attcccatca ttacgacatt agtcagtttg
    11941 tcccgttccg gcagcgaatg aatctggttt atgatctggc tggcggtcag gttagccgta
    12001 tacccctgtt tgccggtcat acagaactta cagttcatct tgcaacctac ttgtgacgac
    12061 acgcacaacg ttgcccggtc atcatccggt atataaaccg actctacaaa atggttctca
    12121 cccactttat aaagatactt caccgtacca tctacagagc gcatttcatc taccggagct
    12181 tccgctccca cctcatagtt ctgcttgagc aactcccggt gtttcaatga caaattagtc
    12241 atatcatcaa tcgaggctac cttcttttcg taaagccagg atgcaatctg cttggcagca
    12301 aagccgggca tacccagtct ttttgtcaat gattgaagct ctacaagagt cattcctaaa
    12361 aggggatatt tagacattct tctttctgtt gatagtttat atctgcaaat gtaaggaaat
    12421 aaagtcgatt tccgtatagc aggaatgtaa aagttaacaa aaaagggaag tatgcctccg
    12481 ttatgattca accacgctga tatattgaag tagcttttgc gccatttcag aatcctcgcc
    12541 attctttttc acttcataac cgtacgcctc acggaaacaa gccagcgcct cttcccgttc
    12601 attacaaaag ctatgcaaaa cccctaagtt ctgacaagcc agaatcgtat cttcttcctc
    12661 ccatcccaaa tacttctttc gcaattcaag ttctctgaag aaagcctctt tcgccattgg
    12721 ataattctcc aacttcacat aagcctgtgc tttgtaataa tataccagac aggaagcatt
    12781 agggtcagca tcatcatgaa tatccaaaga cgttgcaata cgaatcacgt tatcatagtc
    12841 tttattcatg taatactgct gcataatatc acatctcaat gcctcgtagc ggacagtcag
    12901 ttccgccaga cgcggttttt cgctgaaata catttcatgc agaagagact cacggaagaa
    12961 taaagtagat gcctgctcat cgccacgttc attcatcatc cgtttgaatt ccctgcacag
    13021 ataatacaac tgtttatgac aagcgacgat ctgtttttta ctatctatct gtatagcaat
    13081 gtccaacgcc tgattcatca gcatccatgc ttcatcgtat cgtttgatat aataaagaca
    13141 tttaccctgc atacgcaaac atttagccac tccaccggac agtctgccat tcaacgactc
    13201 gtgcatttca gctactttcc ggaatttctc ggcagccctc tcttcctcat ccttatagta
    13261 atcacaataa gccagatatt cggaaagttc aatgacttct gcctgactct tctcatcagc
    13321 agaagccgca tgataatcaa gcgccctatt cagataggtc actgcttcat tgtattgctc
    13381 attgtagtaa tatgccagag ctagatttcg gcaggtgttg gcaatctcca gttccggagt
    13441 cggtacaatg ttttcctgca tcaccaatgc tttcaagaaa cagtcgcatg ccgtttcgta
    13501 ttcttcatta cgggcatacc ggcatccctc attcatcttc aataccgact tggcaatgag
    13561 tggcatggca gcaccttcca tactcttctc actcacagca gctgccgcct tcgtcagatg
    13621 gaaagaactg ctcaagaaag tagccatatc attagcaatg acaggaatta aaaaagaatc
    13681 gatctcatca aagtccaatt cggcatagac ttcaggcgta acttcaggat tgtcgttcat
    13741 gatcgccttc cagctatctt ccaacagaga acgattcgtg cgatacagaa tctcgaaaat
    13801 ctccacatca caaatccaat ccttcaatat atcccattct tgcatcttat agcattgata
    13861 ggtaatctcc actttatagc gatacgaatc atggtagcag aactgtttca tgcgatagtt
    13921 ataatcggca aaagtcaacg gatgggaaag gatttcttcc tcatccagca gagcggaaat
    13981 aatttcatgg cgactatcat ctatacattc gtcatcttga gcgaaatagc gttcgatcgc
    14041 ctctaccatt tgtgtgtcac caatgcaata tcgtcctcct ttgttggtga gccagctgct
    14101 catttccact ctcaactgcg accaaagtat ctgattaatg tctgccatgc tctttacttc
    14161 atcttcggta aatccttcta aagtaagtga aagcattaga agcgttcttc caatctcctc
    14221 gaaaccataa tcggacgaca aacgccgaag cacactgtcg tagaattgct caatctcatt
    14281 gagccgacaa tatccactca tatattcatt tagagcatca tactgaccga acgaaaccag
    14341 ctcattgagc aatacactta aacagcgcgg ttgtctggcc agcacccacg aagcaagaat
    14401 atcttcctgc tgtgcggaca atgccttgga gtaagtagac aaatattgct ttgagaacga
    14461 cttggcatcc acttgtgaaa accc
//
