LOCUS       c00151_gnlPro..        14429 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HLHHGGLG_165.
ACCESSION   c00151_gnlPro..
VERSION     c00151_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 11:03:21
            Original ID  :: gnl|Prokka|HLHHGGLG_165
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14429
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14429
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[217:4429](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      218..4429
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14429
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14429
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             218..4429
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg151_1"
                     /sec_met_domain="HGD-D (E-value: 2.2e-22, bitscore: 72.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.6e-33, bitscore:
                     108.0, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAYKVGLDIGSTTAKMVVLDKDRTTVLFSGYKRHQAKIQECLLG
                     FLYQIKEQLGDIPLSFHITGSVGMGISEKCSLPFVQEVVAATNYVRREHPYTATMIDIG
                     GEDAKVVFFQDGQATDLRMNGNCAGGTGAFIDQMAILLGVSIDELNELALRSNQVYSIA
                     SRCGVFCKTDIQNLIAKNISKENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTF
                     IPALRKAFANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSV
                     TSPFQSDLSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLD
                     NNHRILYSYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFH
                     MDAGIIETIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSF
                     ISTFAQSLDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSY
                     SVVKNCLYKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGAL
                     GCALYAKQIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNSENHYFSGNRC
                     EKVFSNKGSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFT
                     ACGIQVQLSEPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTQQNVNRIFMPFVVFE
                     KKDKQQQNSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKNEALLYKQCYEYLKSLGIR
                     DEVCKNAFSRALQEQYAFEEKIATYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVS
                     DMIAAMGVYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTS
                     FGCGPDAFLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAK
                     DPEPFVSTAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGL
                     KYSNNEVCYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIEN
                     GYTNTPVVSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERG
                     QAARLRDLYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFN
                     PFAQKDVTSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKV
                     QKQINKVNEIGKSFNYFIPFESIFEKAEKAKQVISLGTQFGEGWLISGEILSFASQGVN
                     HVISLQPFGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNIN
                     N"
     CDS             4434..5054
                     /locus_tag="ctg151_2"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEK"
     CDS             complement(5135..5557)
                     /locus_tag="ctg151_3"
                     /transl_table=11
                     /translation="MMRDAEKTVGNMIDKLKTAFIGSIDGEGFPTIKAMLQPRKRKGIK
                     TIYLTTNTSSMRVAQYRENNHACIYFCDTRFFRGVMLRGTMDVLTDSASKEMIWQEGDT
                     MYYPEGVTDPDYCVLKFTAISGRFYSNFKSEDFVVE"
     CDS             complement(5650..6528)
                     /locus_tag="ctg151_4"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLAKSAVHTLNYYD
                     ITFITEGKGAFSVDNQTYEAIPRDVLFSKPGEIRNWDTHHITNGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKMEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMTSIEEGRSREVSNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGFSAKQYIQSKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGE
                     TPLLYRKAHKP"
     CDS             complement(6652..7200)
                     /locus_tag="ctg151_5"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATLPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGADVTSLGYLAGSSK"
     CDS             complement(7241..8605)
                     /locus_tag="ctg151_6"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIATGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHSRIAELMHTPVEAMVDTKNYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLKGTMMPAMSN"
     CDS             complement(8843..9229)
                     /locus_tag="ctg151_7"
                     /transl_table=11
                     /translation="MKEWFTSYSILVRDKEQREAILTRLKENPCQVFHKAPLITVIHPE
                     ASKKEGVLQLCKALGLASEHTLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKERAHYTLN
                     PDRLAAFFRFSNGDPIDQTSSDNS"
     CDS             complement(9204..10409)
                     /locus_tag="ctg151_8"
                     /transl_table=11
                     /translation="MENESSLLSFRHIYYRGKLNSCNYTCSYCPFGKKSHLADTTQDEQ
                     AWNRFIAAIEQWKGEPLQLFIIPYGEALIHRYYRKGMMHLAALPQVAGISCQTNLSFPA
                     KHWLDEIRVAPTVISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCAGAVGSPSAKA
                     VLNDLRNALLPDIYLFINAMQGLRAPLSQEDIQFFSQLDNLFEYDLKNAPAQWEVCAGG
                     RDNCFIDWKGDMYACPRSRVKIGNFYQGDGAVVPLSCKRKVCDCYIAFSNLNNHPLHRI
                     MGEGAFWRIPDKPLITTVFFDVDGTLTDSQGKVPESYANALRYMAQSVSLYLATSLSME
                     QAKKKLGKALFDLFRGGVFADGGLLSYSGQIRCLPVKVYPEVYGESAKVTIHSYEGVVY
                     KL"
     CDS             complement(10421..11698)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg151_9"
                     /sec_met_domain="Radical_SAM (E-value: 3.8e-16, bitscore:
                     51.7, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPLPRYVDYMYSYPHKTAYRSFPSPVSLVPYLKQVEGQKASLY
                     FHIPFCSHKCGYCNLFSLQTNRADYIATYLETLHKQAQQLSPLTTGLAFDSFAIGGGTP
                     LLLTVPQLEYLLDTAALFGVHPSHTFTSVETSPEYADPARLDLLKQAGVARVSIGVQSF
                     LDEELTALKRRPRRDMINQALEAIRKRQFPFFNIDLIYGIKGQTVASFLYSLEQALLFQ
                     PNELFIYPLYVRPGTAITERESDDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSTDAE
                     ISCGDEVMLSCGSGGRSYLGNLHYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQ
                     EERRQRFIIKNLMYYMGLDKAEYERRFGESPDNVPLFRQLAERQWIENTDNGRVCLTSE
                     GMAYSDYIGQLFITPEIRELMETYSY"
     CDS             complement(11695..12549)
                     /locus_tag="ctg151_10"
                     /transl_table=11
                     /translation="MQIDELPAGEQTQNPDLDMNQVVGTHDILMLCFDTLRYDVSKEEE
                     EAGRTPVLNSHGGEWEKRHAPGNFTYPSHFAIFAGFLPSPAEPHSLRSRKWLFFPVQAG
                     TGRIPPAGSYPFTEATFVQSLANVGYETICIGGVNFFSKRNELGRVFPGYFTKSYWLPT
                     FGCTAPDSTEKQIDFALKKLENYPEDKRIFMYINFSAIHYPNCHYVEGKMKDDKESHAA
                     ALQYVDSQLPRLFQAFQKRGNTLVIALSDHGTCYGEDGYEYHCISHETVYTVPYKHFIL
                     TKK"
     CDS             complement(12536..13546)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg151_11"
                     /sec_met_domain="ATP-grasp_3 (E-value: 4.4e-08, bitscore:
                     25.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIVVSNSLSKRIEYFIEAGKHLQVEVRFMTYGELFNCLPQLRQ
                     AVIKLEPCVSDETNFLKYALLNQAYKETLQRLGEMRLSDDVCFLNTPHALLRALDKKET
                     KQVLMDRGLKVTPMLPSPRSFDELRELLADCGRGCFLKPRYGSGAGGIMAVRYQPNRNK
                     WVVYTTLQQVDGVIHNTKRIHRLSTEKEMIPLAEAVMQTEAILEEWIPKEQLQGENYAL
                     RVVCRESEIDYIVVRCSKGSITNLHLNNKAHWWNELSLPEVVRQQIYFQCQEAVQSLDL
                     QYAGVDVLIERGTDIPYIIEVNGQGDHVYQDMFAHNSIYIQQIKNIKKRYNHANR"
ORIGIN
        1 ctactacaac ctaacaagta atagaaatac acaattattc atttacttct tttttacacg
       61 atcgttttcc tccctcacat tccatctttc ttttttccca attcgttaat taaatcaaaa
      121 acttcaatta cgatttgccg tatctaccat atttttacat acattcgcgt ctgacacaga
      181 tgtcaaacac aaggttttaa tttaagatat ttggtatatg aatgcatata aagtgggttt
      241 agacataggc tctactaccg ctaagatggt agtattggac aaagatagaa ctacagtctt
      301 gttttccgga tacaaaaggc atcaggcaaa aatacaagaa tgtttactcg gatttcttta
      361 tcaaataaag gaacagttgg gtgatattcc tttatctttc cacattacgg gctctgttgg
      421 aatgggaatt tcagagaaat gctctctgcc gtttgtgcaa gaggttgtag ctgcaacaaa
      481 ctatgtgcgc cgggagcatc cgtacacagc cactatgatc gatattggag gagaagatgc
      541 gaaagttgtt ttctttcagg acggacaggc tacagacctg cgcatgaatg gaaattgcgc
      601 cggcggaacc ggggctttca ttgaccagat ggctattctg cttggagtct ccatcgacga
      661 attgaatgaa ctggcacttc gttccaatca ggtatactct atcgcttcac gctgcggagt
      721 attctgcaaa acggacatac agaatctgat agccaaaaat atatctaaag aaaatatagc
      781 agcttccatt ttccatgcag tagccgtaca gaccactgtc acacttgcac gcggttgcaa
      841 tatcgtagct ccggtattac tctgcggtgg cccattgact tttattccgg cccttcggaa
      901 agcatttgcc aactatctga atctgtcaca agatacagat ttcatattac cggaaaaagg
      961 aaatctgatc cctgcctggg gagcagcatt ggcagagaac aatgaagaaa gtattcatct
     1021 ctccaacctg atacaggtaa tagaaaacaa actaagtgtt acctcacctt tccagagtga
     1081 tctttctcct atattcgaca gtgaggaaga atatcggtca tggaaaaaag aaaaagacca
     1141 gtataaaatt caatatgcca gtctgcgtcc cggattacag gaagcaacta tcggcataga
     1201 ctccggctct actaccacca aaatcgtagt actcgacaac aatcatcgta tcctttactc
     1261 ctattatcac gacaacaacg gaaaccctat aaaaacagta gagaacggct tgcagaaact
     1321 atatgaagaa tgccggagac gaggaactac cctgcgcata aaaggaggat gttctaccgg
     1381 ttacggagaa gatctgataa aagcggcttt ccacatggat gcgggaatca ttgaaaccat
     1441 cgctcattat gctgctgcca aacatatcag caaagaagtt tcttttatcc tggatattgg
     1501 agggcaggat atgaaagcca tctttgtgaa cgacggagta atcaacagaa tcgaaatcaa
     1561 tgaagcctgt tcctccggtt gcggttcttt tatcagcaca tttgcgcaat cgctggatta
     1621 cagtgtggag gactttgcca aagcagcttg tttttcgcaa gcaccatgtg atctgggtac
     1681 acgttgcaca gtcttcatga actccaaagt aaaacaggta cttcgggaag gagcgtccgt
     1741 agcggatata gctgccggat tatcttattc cgttgttaaa aactgcctgt ataaggttct
     1801 gcaattaaaa gacacggaga tacttggcga ccatattgtc gtgcagggag gaaccatgcg
     1861 taatgattcc atcgtacgaa gtctggaaaa gctgaccggg aaacaaacct tccgcagtaa
     1921 ctgtcctgaa ttgatgggtg ctcttggttg tgccctatat gccaaacaaa tcgaaaatgc
     1981 ccgggtgacg gagctgaacg agatgctcca atgggcacaa tatacttcca agcaacttca
     2041 atgccggggg tgcgagaacc agtgcgccat catgcgatat acgttcaaca gtgaaaacca
     2101 ttacttctcc ggcaaccggt gtgagaaggt gttttccaat aaaggaagcc atgcggacaa
     2161 aggcatcaat acgtatgata aaaagctgga attattattc gaccggagcg cagacattcc
     2221 acaaccccta ttcaccatag gtattccacg tattctgaat atgtatgagg aatacccttt
     2281 ctggcatacc ttatttactg cttgcggcat tcaggtacag ttgtcggaac cctctacatt
     2341 cagcaaatac gagactgctg ccggcatggt gatgtctgat aacatctgct tccctgccaa
     2401 acttgtgcac agtcatatcc gtaatctgac gcaacaaaac gtcaaccgga tatttatgcc
     2461 gttcgtcgtt ttcgagaaaa aggataagca acagcaaaac agctataatt gccccatcgt
     2521 ttccggttat tcggaagtca tcaaaagtgt acaggaagag aatataccga tagatgctcc
     2581 gactatcacc ttcaaaaatg aagcattgct gtataaacaa tgctatgaat atctgaaatc
     2641 tttgggtatc agggatgagg tatgcaaaaa tgccttctca cgcgcattac aggaacaata
     2701 tgctttcgaa gaaaaaattg ctacctataa tcaggaagtt ctgaacgagg gacgggaaaa
     2761 acacaaactg attatcttac tcgccggacg cccttaccat agcgatccac tgatacagca
     2821 caaggtttcg gacatgattg ctgcgatggg agtttatgtg ataactgatg atattgtccg
     2881 ccagcaggag atttcattgg aaaagactca ttacctctct caatgggcat ttaccaaccg
     2941 tattctgaaa gcaaccaagt gggcggcaat gcaagagggt gacatacaat atatgcagat
     3001 gacttctttt ggctgcggtc cggatgcttt ccttatagat gaagtacgta acttgctgaa
     3061 acgatacggc aagaatctta ctttgctcaa gatagacgat gttaataata tcggctccat
     3121 caaattacga gtccgctcgt tggtggaaag cttgaatttc agtttgaaac attctcaagc
     3181 gaaagatccc gagccatttg tttcaactgc tcctttcacc aagaaagaca aaaagaagaa
     3241 aatcctcgct ccattcttta cgcctttcat ttcaccactc attccatcca tcatgaaggt
     3301 ggccggatat gaaatggaaa cgttaccgtt gagcgacacc gcatcttgcg actggggatt
     3361 gaaatactcc aataatgagg tatgttatcc ggcaacattg attgtcggcg acatagtaaa
     3421 agcctttaaa agcggacgtt atgatcctgc caatacgtgc gttgccatca cacaaaccgg
     3481 tggacaatgt cgtgccagca actatatttc actgataaaa aaggcattga ttgagaatgg
     3541 atacaccaat acaccggtgg tatcacttgc tttcggcagt ggtatcgaaa atgagcaatc
     3601 cggttttaag gtaaactggc tcaaggtttt accaatcata cttgcgtctg tgttatacag
     3661 tgattgcatt gccaaattct attatgcagc tgtcgttcgt gagaaagaac ggggacaggc
     3721 cgcccgtctg cgcgatcttt atctggatac agcacagccc attatccaga aaaataaacc
     3781 ggaggacttg ttgagttact tatatctcgc tgccagagac ttcaacaaaa tctgtgaaca
     3841 gagatcctgt cacaaagtag gtattgttgg agaaatattc ctgaagttca acccttttgc
     3901 tcaaaaggac gtcacctcat ggctcatcaa ccagaagatc gaagtgattc cgccactgat
     3961 aagtgatttc ttcatgcagg gatttgtcaa cctgaaagtg agacagaacc aacacttgca
     4021 gcgaaaactc actcccgact ttgttataga ctggttatac aagaaagtcc agaaacaaat
     4081 taataaggtg aatgaaatcg gcaaaagttt caattacttc ataccgttcg aatctatctt
     4141 tgaaaaggca gaaaaagcta aacaagtcat ctccttgggc acccagtttg gagagggttg
     4201 gctgatatcc ggtgaaatac tatcctttgc ttcccaagga gtcaatcatg tcattagctt
     4261 gcaacctttc ggatgcattg ccaatcacat tgtagaaaaa ggaatagaaa aacgtataaa
     4321 atcgctgtgc cctcaaatga atatactatc tttagacttt gacagtagcg tcagcgatgt
     4381 gaacataaca aacagattat tactttttat tgacaacata aacaactaaa attatggcta
     4441 caacggaaca tagcgattta gagcagcaaa taataaaaac tgcccaacaa ctttttatag
     4501 aaaaaggatt tgtggagacc agcatgagtg atattgctgc aacggtagga atcaaccggc
     4561 ccactttaca ttattatttc agaaccaaag ataagatgtt caaagccgtg ttcggctcga
     4621 tagtcatgtc tttaatgccg aaaatacagg atatagtaaa acaggatatc ccatttatgg
     4681 agcgactgag catgattctg gatgagtata ttgagctttt cacaagtaat ccctgtcttc
     4741 ccagattcat ttgtggggaa atacagcgtg atgtaaacca cttgcttgcc actgcaaaag
     4801 aacttcagtt cggagatgct ttatcccaag tgaaagacag tatactgaca gcaatggaag
     4861 acggtaaact taaaaaggtt ccgatacata ttgtatttct gactgtctac agcctattga
     4921 gctatccatt tcttgccaag aacctgatag tatctttatt cttggaagat gaagccgctt
     4981 ttgctgactt cctgcaagaa tggaaacaaa acatcatcaa ccaattgcag aacttattgt
     5041 gttatgagaa atagtataga cactataaac aaaaagagac tgaatattca gtctcttttt
     5101 gtttattacc attccaatca ccccatcttg caccttattc gaccacaaaa tcttccgatt
     5161 taaaattact atagaaacgt cctgaaatag cagtaaactt caatacacag taatcgggat
     5221 ccgtcactcc ctccggataa tacatggtat ctccctcctg ccagatcatc tctttactgg
     5281 cactatccgt caagacatcc atcgtaccgc gtagcatgac acctctaaag aatctcgtat
     5341 cacagaagta gatacacgca tggttgttct cacggtattg cgccacacgc atggacgacg
     5401 tatttgttgt caaataaatc gtttttatcc cctttctttt tctgggttgc aacattgctt
     5461 tgatggtagg aaatccttca ccgtctatcg aaccgataaa agctgttttc agcttatcaa
     5521 tcatgttgcc tactgttttt tccgcgtctc tcatcatttt actttttatt attggtttat
     5581 tatctgatgc gaaagtagag aaatgccagg aaagcaatgc aataaaaaga aaggtagaaa
     5641 tagcactttt tacggtttgt gtgctttacg atacaataac ggagtttctc ccgtatgctg
     5701 ccggaagcta cggataaaat aagaaaccgt tgaaaaacag agttcaaatg caatatcagc
     5761 tataggaaag tccgtataaa caagcagcct cttagcctct tccatcacct tgctctgaat
     5821 atattgtttt gcgctgaacc ccatggtcga ggttatcatc tcattgagat agttaggagt
     5881 aatgcagagc ttatccgcat aatattgaac cgaatgttgc tcttttgcat gtgtagcaac
     5941 caaattcatg aatttactta catgattatt ggaaacttcc ctacttctgc cctcctctat
     6001 cgaagtcatt ttaaggtaag cacggtccag caacatcagg acttcataaa gcaatgctct
     6061 caaaacgtgt acatcgccct gttgatacga atcaatctcc atctttatat catgcaaggt
     6121 ttcaagtatg cgtgtataaa gctcatcaga caaatgtagt agcgatgaag aactttctat
     6181 ctgaaaaaac gaaagatgct gtacaaacaa agaatcttta aagaggaaag acaaaaattc
     6241 ttcttcgaaa atcagagcat acccattggt gatatgatga gtatcccagt tccggatttc
     6301 ccccggttta gagaaaagaa cgtcacgagg aattgcttca taggtttggt tatcgactga
     6361 aaaagctccc ttaccttctg ttataaaagt aatatcataa taatttagag tgtggacagc
     6421 acttttagcc aggaacttct tcacatactt cagttctact acatcgacca aaagttcact
     6481 cccatactta tgcttataaa aagtatatcg aggtattgag tttttcattc agaatacaaa
     6541 aatagtattc cttaccaaat aatccaaaga cttttcaaat tcgattcgat tgaataagcc
     6601 atgaaccatc tgataaggaa tacatagaaa aatatgtcta ggttatattt cctatttaga
     6661 acttccggcc agatatccca aactggtcac atctgccccc aagtaatgat taatgtgctt
     6721 caatggcacc ctgtacagaa tatccggaat ttccgccaat aaagagaggt acctttccct
     6781 tactgtcagc ttgcgggcat tcatatcctc ttcctcttta aagtaaaact gatactccat
     6841 cagttgacgg accagattcg caaatgaaat tgaagatgca cacaactctt caatctcctc
     6901 ttcactgatg taataagcag cacatttcgt cagtgtcttg atagaatact gacttgaatt
     6961 atagcataac acagcatcac ccgcagagaa aaaccgattg gttctctctt ctccttcatg
     7021 agtggtatat gtatgcaaaa taccggaaac aataatgtac aagctctgct ctggcaatgt
     7081 ggcagaagca atcgtttctc ctttatccag atacaccatt tccattcgag ccaacagctc
     7141 tttcacttct ctttcatcca cctgatactc aaaacagagt ttcttcaaat aagcttccat
     7201 acaaaataga ttttagttaa tatatgtcac ttaaaaacac ctaattcgac atagcaggca
     7261 tcattgtgcc tttcaaatat aatttccttt gggtatatcg taaataccag atacagatca
     7321 ataatgaaac gaccgttgaa atgggtggag caaatcccat gataaacagc gacgagctat
     7381 ctatctggct gaaccagtat gacaacggta tacgaaacag gaaagtggct atcagactgt
     7441 gaatcatcgg gaataacgag tttccttgtc cgctgaaata agaattaatg cagaacacga
     7501 aactaaccac gatgcagtcg atgctatacc ctcgcaaata atctgccgcc attgccacca
     7561 cagcagcatc tttcgtaaag aaagcagtaa gagtctccgg caggaattgc gaatacacgc
     7621 aaaccgacac accgaaaaca agagcaatcc caatccccga agccagacat ttattcattc
     7681 tcttgataag tcccgctcca taattttgtg cagtcatggt tgccacagcc gatgatatag
     7741 ccatcggagg cagcatagca aacacaatga ttttctcaac aacacccagg gaagcagatg
     7801 caatgactcc catctgattg acaatgacag tgataatcag aaaagaaaca ttgattaaag
     7861 catcctgcaa agcaataggt gctcccaaca ccaagatctt tttagacaga ttccggttca
     7921 atcgaatatc tttccgtgaa aagtcaaaat ggaatccgtg ccggtataag aaccagagcg
     7981 ctattccaaa gctgactcct tgtgcagtta cagtagcgat agccgctccc gtagcccccc
     8041 aatggaaata accgaccaat ataaaatcga gcactatatt tatcacacat gccagcccaa
     8101 caaaataaag tggtgtttta gaatcaccca atccacgcaa aataccacat acaacattat
     8161 atcctactat aaacagaata cccagagagc ataccaaaat atagtttttc gtatctacca
     8221 tcgcttcgac aggagtatgc atcagttctg ctatccgact atgaaaaagc accatgacca
     8281 aagttagcac tacgccggtt attgaaaaca accatacgga agacccgata gtaaaagcta
     8341 cttttcgatt gtctttagct ccggtagcaa tagcaatcag cactgttgtc ccggtagtaa
     8401 tacccagaat aatacctgta attgtctgca tcacctgact accaatagct acggctgcca
     8461 cacttgccga atcatcatat tgtccgacaa cgaaaaggtc agctccgcca taaagtgcct
     8521 ggagcacatt ggcaatcaga aaaggtactg caaactgcaa caataccttc ggtacgcttc
     8581 cttgtgtcaa atctaactct ttcatagttt cttcgatact tttcctcttt atcttatttt
     8641 gttacaacat aaaaaaagtg ccggacaagc gaatgatttg caccattcat cttatccagc
     8701 actataatta ttattatagc accctccgat gaggattttt atgcctgtcc ctatttcagg
     8761 gctgcaaata tgggctttgt tttcataatt accaaatttt aaccggtttt tattttctta
     8821 tgaagatgta actagctata tatcaactat tatcagacga ggtttggtct ataggatctc
     8881 cgttagaaaa acgaaagaaa gctgccaacc gatccggatt cagcgtataa tgtgcgcgtt
     8941 cttttaataa gggttccgca ttcattacgg cacaagaatg agaaaccacg gacatcatcg
     9001 gccagtcctt taacgaattt cctacaacta aagtgtgttc agaagctaaa cccaaagcct
     9061 tacataactg aagcaccccc tcttttttac ttgcttcagg atgaatgact gttatcagcg
     9121 gagctttatg aaagacctgg cagggattct ctttcaaccg ggtaagaata gcttctctct
     9181 gttctttatc acgtaccaat atactataac ttgtaaacca ctccttcata actatgaata
     9241 gtgacttttg cagattctcc atatacctcc ggatatactt tcaccggcaa acacctgatc
     9301 tggcccgaat aagataataa acctccatct gcaaacactc ctcccctgaa taaatcaaaa
     9361 agagcctttc ccagcttttt cttcgcctgc tccatcgaca gagaagtggc aagatataag
     9421 gaaacggact gtgccatata tcgcaaagcg ttagcataac tttctggaac ttttccctgt
     9481 gaatcagtca gtgttccatc cacatcgaag aaaacagtcg taataagtgg cttgtccggt
     9541 attcgccaga atgccccttc tcccattatt cgatgtaaag ggtgattgtt caggttacta
     9601 aatgcaatat aacagtcaca aaccttcctc ttgcaagata acggcacaac agctccatca
     9661 ccttgataaa aattacctat cttcacccgg cttcggggac aagcatacat atcccctttc
     9721 caatcgataa aacaattatc ccttcctcct gcgcaaactt cccattgtgc cggagcattc
     9781 ttcaagtcat actcaaaaag attatccagt tgactgaaaa actgaatatc ttcctgactt
     9841 aatggtgccc ttaacccttg catagcatta atgaataaat aaatatccgg taaaagagca
     9901 ttccgtaaat cattaagtac agcctttgca gagggacttc ctaccgctcc ggcacatacc
     9961 tgtattcccg catgatggag tatatgaatc tgatgcgcaa atttctctac cgaagtcatc
    10021 tcaggatgaa aactagccca aagccttatc ttacttatca cagtgggagc cacacgaatc
    10081 tcatcaagcc agtgtttagc cggaaaagaa aggttagtct gacaggaaat tccggccacc
    10141 tgtggcaatg ccgccaaatg catcattcct ttccgataat aacgatggat caacgcttca
    10201 ccgtaaggaa taataaatag ctgcaacggc tcccctttcc attgttcaat agctgctata
    10261 aaacgattcc atgcctgttc atcctgtgtt gtatctgcca gatgcgactt cttgccgaaa
    10321 gggcaataag aacaggtata gttgcagcta ttcaatttac cgcgataata tatatgcctg
    10381 aaggaaagta aagagctttc gttttccatt tctatttcgt tcaataagaa taagtttcca
    10441 tcagttctct tatttcagga gtaatgaaca actgaccaat ataatcggag tatgccattc
    10501 cttcggaagt cagacaaaca cgaccgttat ccgtattttc tatccattgc cgttcagcta
    10561 actgtcgaaa caacggcaca ttatccggtg attctccaaa acgacgctca tattcggcct
    10621 tatcaagccc catataatac atcagatttt taatgatgaa acgttgtcgc cgttcttcct
    10681 gagaaagaat aaatccatta cgagccactg taaaatcagt agtgcccata taatcatcta
    10741 tctctccggc aatacaacgc tggcaaacag tataccgggt ggcataatgc aaattaccca
    10801 ggtaactgcg tccgccggag ccacacgaca gcatcacttc atccccacat gagatttccg
    10861 catcagtaga cggatgatga ataaaacgtc gcatcgaagt ttgtagaaaa cctctgtctt
    10921 tcaacaaatc acaagcggca caatacatct gaaaacagac atcgtcggat tcccgctctg
    10981 tgatagccgt tcccggtcgc acatatagcg gatagataaa gagttcgtta ggctgaaaca
    11041 gaagagcctg ttccaatgaa taaagaaagc tggccacagt ttgtcctttg attccgtaaa
    11101 tcaaatcaat attaaaaaac gggaattgtc tcttccgaat agcctccagc gcctgattaa
    11161 tcatgtctcg ccggggacgt cttttcaaag cagttaattc ttcgtcaagg aaactctgta
    11221 cgccaatact cacacgagcc actcctgctt gcttcaataa gtccaaacgg gcaggatcgg
    11281 catattccgg cgatgtttct acggaagtaa aggtatgtga aggatgcact ccgaataagg
    11341 cagctgtatc cagtaagtat tccagttgag gaacagtgag gagcaacggt gtgcctcctc
    11401 caatggcgaa actatcaaat gccagtccgg tagtgagtgg agacaactgt tgcgcctgct
    11461 tgtgaagagt ttccaaataa gttgcgatat aatccgcacg atttgtttgc agagaaaaca
    11521 ggttgcaata tccacattta tgactacaaa aaggaatatg gaaataaagc gatgctttct
    11581 gtccttccac ctgtttcagg taaggaacca gcgaaaccgg ggacggaaaa gaacgataag
    11641 cagttttatg tggataacta tacatatagt ctacatatcg tggtagcggt tgattcattt
    11701 tttcgttaaa ataaagtgtt tgtaagggac tgtataaacc gtttcgtgag atatgcaatg
    11761 atattcatat ccatcctctc catagcaagt gccatgatcg gaaagagcaa tcaccagcgt
    11821 atttccccgc ttctgaaagg cctgaaataa acggggtagc tgactgtcga catattgcag
    11881 cgcggcagcg tgtgattcct tatcatcctt cattttgcct tccacataat gacagttcgg
    11941 ataatgaata gcagaaaaat tgatatacat aaaaatccgt ttgtcctccg gatagttttc
    12001 gagtttcttc aatgcaaaat caatttgttt ttcagtacta tcgggtgccg tgcatccaaa
    12061 ggtcggcagc caataacttt tagtaaagta accgggaaac acacgcccca gttcattacg
    12121 cttgctgaag aagttcaccc ctcctataca aatcgtttca tagcctacat tggcaaggct
    12181 ttgcacaaaa gttgcttccg taaacggata acttcccgca ggcggaatac gtcccgtacc
    12241 agcttgcaca gggaaaaaca accacttacg gctgcgtagc gaatgaggtt ccgccggaga
    12301 aggcagaaat cctgcaaaga tggcaaaatg agacgggtaa gtaaaatttc ccggcgcatg
    12361 tcttttttcc cattctcctc cgtgactgtt cagtaccggt gttcttcctg cctcttcttc
    12421 ctccttgctg acatcataac gcaaggtatc aaagcaaagc atcaatatat catgagtacc
    12481 caccacctga ttcatatcca gatccggatt ttgggtctgt tcgccagccg gcagttcatc
    12541 tatttgcatg gttatatctc ttttttatgt tttttatctg ttgaatataa atagaattat
    12601 gagcaaacat atcctgatac acatgatctc cctgtccgtt gacttctatt atataaggaa
    12661 tatctgttcc tctctctatc agtacatcca ctccggcata ttgcaaatcc aaagattgaa
    12721 ccgcttcctg acactgaaaa tagatttgtt gccgcactac ttccggcaaa gacaattcgt
    12781 tccaccaatg tgccttattg ttcagatgca gattggttat gcttccttta ctgcatctca
    12841 caacgatata atcaatttca gattcccggc acactacacg aagagcataa ttctctccct
    12901 gcaactgctc tttaggaatc cattcttcta aaatagcttc tgtttgcatc acagcttccg
    12961 ccaacgggat catctctttt tccgtactca aacggtggat acgtttagtg ttatgaatga
    13021 ctccatccac ttgttgtaag gtagtataga ctacccattt attccggttg ggttgatagc
    13081 gaacagccat aatacctccc gcccccgaac cgtaacgggg tttcaaaaag catcctctac
    13141 cgcaatcggc aagaagctct ctcaactcat caaaagaacg gggagaaggt aacatcggag
    13201 tcactttcaa ccctctgtcc atcaacactt gtttagtttc ctttttatca agagcacgta
    13261 ataaagcatg gggagtattc aaaaagcaca cgtcatcaga taacctcatc tcgcctaaac
    13321 gttgcagtgt ctccttatat gcctgattca acagcgcata tttcaggaaa ttcgtttcat
    13381 cgcttacaca aggttccagt ttgataactg cctgccgtag ttgcggcaag cagttaaaaa
    13441 gttccccgta agtcataaaa cgaacttcca cctgcaagtg tttgcctgct tcaataaagt
    13501 attctatacg tttggacaga gagttgctga caacgattat ctgcatctcc tattctgtaa
    13561 tcatcgggta ataccacaat tcaccatcat attcatctgc ctcttcagtt tcagcaatat
    13621 ctattttcat agggagactc tgcaactgtt tcttcatctc cttgctcaaa taattatagc
    13681 gcatattgat aaacttcaaa tgagcgatct tatccatatt atccagcaat aattgggcac
    13741 cttcatcttt gagagtacca gccgaaacat ccattgtttc aagttgggga agaatatccg
    13801 actccaggaa catttctaca atcttgtcct gttcttcaga gttgacgatc cccagataag
    13861 tcagcttcgg gaaacgttct ttggagaaca acggacggaa tatctcaata tcagcttcaa
    13921 atccataatc ttccacacca acatatagaa tcagtttttc cagattgggg aaatcagaac
    13981 caagaatatc ttctaccact tcggtaggca ggccaccact gataatttcg agtgaccgca
    14041 actccggccg tgaagtcttt cccaaacgca gattattggt tcctttgatt ttcagatctt
    14101 tcaatttagg catggcatcg agcagcggac taatatcagc ttgttcaatc catgaaatct
    14161 cctgttcttc ctgctcaata tctccccaga acaagccttc tatttgtgcg aacttctcct
    14221 tattttcaat cattccctgt aataaggcag aacagtcgcc accctcataa tcccaacaac
    14281 cgattgttat ttgtttatat tcagagagat gtttatcttt caatatctta tccagaagat
    14341 tcacattgtt ttcatactca tcataactca aagtatattt cttggcttcc actttcattt
    14401 cacgtgcagt ttcttcagca gtttctaca
//
