LOCUS       c00010_gnlPro..        16373 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PHJBGPKJ_10.
ACCESSION   c00010_gnlPro..
VERSION     c00010_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 11:06:12
            Original ID  :: gnl|Prokka|PHJBGPKJ_10
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16373
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16373
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2821:6373](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2822..6373
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16373
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16373
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(249..1463)
                     /locus_tag="ctg10_1"
                     /transl_table=11
                     /translation="LNSFKMTKKALYIFNPEHDLALASGETNYMAPASARQMASELALL
                     PMWYAEEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGWDIAIR
                     KRLLDLGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKS
                     FVESHDTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGKQQGGVIGEPLYNKVEDFA
                     MEFRSSSNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLLEYIPVEEIYKLRDRLE
                     QELSLRFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPT
                     STGAFQISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFIS
                     KSVFL"
     CDS             1611..2789
                     /locus_tag="ctg10_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2822..6373
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg10_3"
                     /sec_met_domain="PFOR_II (E-value: 3.1e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 3.6e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 3.6e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.3e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 1.2e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 9.9e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 6.1e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6526..7392)
                     /locus_tag="ctg10_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7413..8237)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg10_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 6.2e-29, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8234..9460)
                     /locus_tag="ctg10_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9760..10098)
                     /locus_tag="ctg10_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10182..11477
                     /locus_tag="ctg10_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11617..14457)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 63; E-value: 1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg10_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 9e-20, bitscore:
                     63.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYTKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKVMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDQLIQLSH
                     QLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQRRMLLLVQRNVNILL
                     RLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAVARKKHIHFSFDYMPDTDYR
                     TLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIRFTVANTGSMISAEH
                     IRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQGTIFTVDLPVQTCET
                     VVSENSPAFSVSATSVTSTDATTSAVAGVPATPATSGYSGSSSLNDALTYEEEELEKSY
                     DSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPG
                     MDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVR
                     NLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGL
                     SRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCY
                     REQFGESPTDLLKRKG"
ORIGIN
        1 tatcttaaat gacaacttat acaggaatta caaagggaca agtaaactta tttaggtttt
       61 aaaaaatatt gagtaaacta acttaggtat aacaagcgaa gttgtcaact aaatccagta
      121 cagtacacac atggcatgtg attacttgtt tcatgcaatg aaactttttg tttctcggtg
      181 tggaaccaat ggtttcacta catgaaacta tcagtttcac accgagaaac cataacttcg
      241 atataatatc acaaaaacac gctttttgag ataaacaccc acgcccgata actactcttt
      301 ttatgagccg gcaccaatga caaatagcct gattttattc ttccttgttc tatttccaaa
      361 ggataagcct cctccatttc tttgtgtgct ctccaggctg ttccttccgt agggtaatag
      421 cttatttgaa aagctcctgt tgaagtagga tagatataat ggtcataaat atgacgcgct
      481 actactccca tattcatcct caagttgatt tccacgcaag gatgaatccg ataaacagga
      541 gattctggaa agcgacagat catcatatcc actcccaaat aaccattata aatggttccg
      601 aaacggaggg ataattcttg ttcaaggcgg tcgcgcaatt tataaatttc ttcgacaggg
      661 atatattcca aaagattccg ttcgatggct gcatctgaaa tcagcagatt accttcgtac
      721 gccccacttc cacccgtacg gaattgagag tatccggcaa agccaaatcg accattactc
      781 gaagaacgaa attccatagc aaaatcttcc accttattat atagaggttc gccaataaca
      841 cctccttgct gtttgccaat gcgtgagcac caaccggaaa tagaaggagt atatacacct
      901 ttgcaccagt tcagcccttt cccgctaccg gataaaggag ctttcagtaa acaagtatca
      961 tgtgattcta caaatgactt ccattcttcg ggaaacgtca ggtaaaaaga ctctccacaa
     1021 aaacaggctc ccagttgtag ctgtggtaat aatcccacag cgcaggaacg atgggaacag
     1081 aaacgcagtt tatccaattg ctcaatagaa ggaagctcgc tttcttccac tcccaaatcc
     1141 aacagtcgtt ttcttattgc tatatcccag ccccaaggac gaatatccaa attccgctcc
     1201 gaagcaagtt caggttctgt catcaaatca accgaaagtc ctaataattc ctgtatcttc
     1261 ttcacatagt cgagattata agcggaagga gccaatacaa cacttccctc ttctgcatac
     1321 cacatcggca acaaagccaa ttcggatgcc atctgccggg cggaagccgg tgccatatag
     1381 tttgtttcac cgctggctaa cgccaaatca tgttccggat tgaatatata aagagccttt
     1441 tttgtcattt taaacgaatt caaaacttta ttctgcaaat atatacagga aatagtcagg
     1501 aatggctaca ataaacagaa agttctaatt aaactcacaa ttttgccatc tctactttgc
     1561 aaatcctaaa aaaagcagta tatttgccac ccgaaaaaca aagaactgaa atggaatcat
     1621 tctatcgcac acacgcctac ctcgttgagc acaccaatgc ccccgttcgc cgcgatctta
     1681 tggacgagat cgactggagc gaccgcctga ttggtatcaa agggacacgt ggcgtaggaa
     1741 aaaccacttt ccttctccaa tacgccaaag aaaaatttgg gaacgaccgc tcctgcctgt
     1801 tcatcaacat gaacaacttc tacttctctg gccacagcat tgtagacttt gctaacgaat
     1861 ttcagaaacg tggcggaaaa gtattgttga tcgaccaggt gttcaaacat ccggaatgga
     1921 gcaaagagtt acgcatgtgt tacgaccgtt ttcctaacct gaaaattgtc ttcaccggct
     1981 cgtccgtgat gcgactgaaa gaagaaaatc ttgaattacg tgatatcgcc aagagctata
     2041 acctgcgcgg attttctttt cgcgaatacc tgaacttaca gacaggcatg aaattcaggg
     2101 catacagcct cgaagaaatt cttagcactc acgaacagat tgccaaagga gtactctcta
     2161 aagttcgtcc gctggattac ttccaggatt acctgcatca tgggttctat ccgttcttcc
     2221 tcgagaagcg taacttctcg gagaatttgc tgaaaacgat gaacatgatg gtggaagtag
     2281 atatacttct catcaaacaa attgaactga aatatctttc aaagataaaa aaattactat
     2341 atttgctcgc tgtcgacggg ccgaaagctc caaatgtgag ccaactggca agcgacatac
     2401 agacatctcg cgccacggtg atgaactata tcaagtatct ggcagatgcg cgactcatta
     2461 atctggttta tccgaaaggg gaagaattcc ctaaaaaacc ttcgaagata atgatgcaca
     2521 actccaacct gatgtattcc atctacccgg tgaaagtgga ggagcaggat gtgctcgaca
     2581 ctttctttgt gaattcttta tggaaagacc ataaggtaca taaaggagat aaaaacgtct
     2641 cttttatggt ggacgaagta atgccgttca aaatttgcca ggaaggagca aagatcaaga
     2701 acaatccgaa tgtgacgtac gcgttgcata aggctgaaat aggtcggggc aaccagatac
     2761 ctctctggat gttcggcttt ttatattaaa agatttattt acttaaatat ttaatttagt
     2821 tatgactaaa cagaagaaat tcatcacttg tgatggtaac caggctgcag cgcatatctc
     2881 gtatatgttc tctgaagtag ctgctatcta ccccatcact ccttcttcga ctatggctga
     2941 gtacgtagac gaatgggctg ccgcaggacg taagaacatc ttcggcgaaa cagtattggt
     3001 acaggaaatg caatctgaag gtggtgctgc cggtgcagtt cacggttctc ttcaggctgg
     3061 tgcgttgact actacttaca ctgcttctca gggtcttctc ctgatgatcc ctaacatgta
     3121 caaaattgcc ggtgagttct tgccttgcgt attccatgta tctgctcgta cattggcttc
     3181 tcacgcattg tgtatcttcg gtgaccacca agacgtaatg tcagctcgtc agactggctt
     3241 tgcgatgttg gctgaaggct ctgtacagga agttatggat ttggctggtg ttgctcactt
     3301 ggctactatc aaatctcgtg ttccgttcat gaacttcttc gatggtttcc gtacatctca
     3361 cgaaatccag aagattgaaa tgttggaaaa tgatgatctt gctccgctga ttgatcagga
     3421 agctttggct gaattccgtg cccgcgcact gaatccgatg aatccggttg ctcgtggtat
     3481 ggctgaaaat cctgaccatt tcttccaaca tcgtgaatca tgcaacaact actatgaagc
     3541 agttcctgct atcgtagaag aatacatgaa tgaaatttct aagattacag gtcgtaaata
     3601 cggtttgttc gattattatg gtgcagaaga tgcagaacgc gtaattatcg ctatgggttc
     3661 tgtaacagaa gctgcccgcg aagctatcga ccacttggta gcaaatggcg aaaaagtggg
     3721 tatggttgcc gtacacctgt atcgtccgtt ctctgctaaa cacttcctgg ctgctgtacc
     3781 taagactgcc aagactatcg cagttcttga ccgtactaaa gaaccgggcg ctaacggcga
     3841 acctctttac cttgacgtta aagactgctt ctacggcgca gaaaatgctc cggttatcgt
     3901 tggcggtcgc tacggtttgg gttcaaaaga tactactcct gctcaaattc tttcagtatt
     3961 cgagaacttg gccatgccaa tgccgaagaa tcacttcact atcggtatcg tagacgacgt
     4021 tactttcact tctcttcctc aaaaagaaga aatcgcttta ggcggtgaag gaatgttcga
     4081 agctaaattc tacggtttgg gtgctgacgg tacagtaggt gctaacaaga actctgtaaa
     4141 gattatcggt gacaacactg acaaacactg ccaggcttac ttctcttatg actctaagaa
     4201 gtcaggtggt ttcacttgtt ctcacttgcg tttcggtgat actccgatcc gttccactta
     4261 tttggtaaat actccgaact tcgttgcttg tcacgttcag gcttacctgc acatgtacga
     4321 tgtaactcgt ggtttgcgta agaacggttc tttcttgctg aacactatct gggaaggtga
     4381 agaactggct aagaacctgc ctaacaaggt taagaaatat tttgcacaga acaacatttc
     4441 cgtatactat atcaacgcaa cacagattgc attggaaatt ggtttgggta atcgtaccaa
     4501 cactatcctt caatctgcat tcttccgtat cacaggtgtt attcctgtag accaggctgt
     4561 tgaacagatg aagaaattca tcgttaagtc ttacggtaag aagggtgaag acgttgttaa
     4621 caagaactat gctgccgttg accgtggtgg tgaatacaag actttagctg ttgatcctgc
     4681 ttgggctaac ctgccggatg atgcaaaagc tgaaaacaac gatcctgcat tcatcaacga
     4741 agtagttcgt ccgatcaatg cacaagatgg tgacttgctg cctgtatctg cattcaaggg
     4801 tatcgaagac ggtacttggt atcaaggtac ttctaaatac gaaaaacgtg gtgtagccgc
     4861 attcgttcct gaatggaatc cagaaaactg tatccagtgt aacaagtgtg catacgtttg
     4921 tcctcacgct tctatccgtc cgttcgtact cgatgctgaa gagcagaagg gtgctaagtt
     4981 cgaacaattg aaagcagtag gtaaagtatt cgacggtatg acattccgta tccaggttga
     5041 cgttctcgac tgtctgggtt gcggtaactg tgctgacatc tgtccgggta atccgaagaa
     5101 gggtggcaaa gcattgacaa tgaaacacct cgaaagccaa ttggctgaag ctgacaactg
     5161 gacttactgt gctgaaaacg tgaagactaa acaacatctt gttgatatca agtctaacgt
     5221 gaagaactca cagttcgcta ctccgttgtt tgagttctct ggtgcttgct ctggttgtgg
     5281 tgaaactccg tatgtgaaat tgatttctca attgttcggt gaccgtgaaa tggttgctaa
     5341 cgctaccgga tgttcttcta tctactctgg ttcagttcct tctactccgt atactacgaa
     5401 cgaaaacggt cacggtcctg cttgggctaa ctcactgttc gaagacttct gtgaattcgg
     5461 tttgggtatg gaattggcta acgaaaagat gcgtgctcgt atcgtgaagt tattcaacga
     5521 aatccttgct gccgacaacg cttcacctga agcaaaagaa gtgctgaaag catggattga
     5581 aaacatgtac gatgctgaca agactaaaga attggctccc caagtgaaag cagtgattga
     5641 agaaggtctt tctcacggat gtcctatttg caaagaactg aaaggactga ctcaatatct
     5701 tgtaaaacgc agccaatgga tcattggtgg tgacggtgct tcttacgata tcggttatgg
     5761 tggtcttgac catgtaatcg cttccggtaa ggacgttaac atcctcgttc tggatactga
     5821 agtttactct aacacaggtg gtcagtcttc taaggctact ccggtaggtg ctatcgctaa
     5881 gttcgctgct gctggtaagc gcgtacgtaa gaaagacctc ggtctgatgg ctactactta
     5941 cggttatgta tatgttgcac agatcgctat gggtgctgac caagctcaaa ctctgaaagc
     6001 tatccgtgaa gctgaagcat atccgggacc atctttgatt atcgcttacg ctccatgtat
     6061 caaccacggt ctgaaagcag gtatgggtaa gagccaggaa gaagaagaaa aagctgttaa
     6121 gtgcggttac tggcacttgt ggcgttacaa cccagctttg gaagaagaag gcaagaaccc
     6181 attccaattg gatagcaaag aaccgaactg ggaagatttc caaggtttct tgaagggtga
     6241 agttcgttac gcttctgtaa tgaaacaata tcctactgaa gctgaagaac tgtttaaagc
     6301 tgctgaagaa aacgctaaat ggcgttacaa cagctacaaa cgtttggcta gagaaaactg
     6361 gggtgctgaa taatagtaat accctataaa tataaagcgg taatcttatc aaagattacc
     6421 gcttttttat tgtatgaact ctgtccaaca taaacagtac tccctttttc ccactagagt
     6481 tcatgtctat tttatattta aaattaagaa taacaatgct ccaatctatt tattctctga
     6541 cttcggaatc caactatcca ccaacagccg atgctcatcc ctccatttac gggctatttc
     6601 ttcttcatcc atcctggcat ccttcatagc tgtcataaaa gagctaagtt cttctgtcgt
     6661 tagtttgatg ttgccaaaga attcggcagc aaacggatct ttctcactga atcctttcca
     6721 tgcaatagca tgtatttctt ccaagtctcc atatactttc ttcggatcat ccaagaattt
     6781 caagtcaaac tggtcgaaca tccaatgcgg tgtccacccc gtaatgacaa tccattctcc
     6841 tttgtccatc gcttttttca aagaagccag catggtggaa ctacttgaag tcatgagggt
     6901 atacccatca agtccgtaag cagcaatggc cttatcggtc gtcttcatta tccctgctcc
     6961 cgcatcaatt cctactattt cagaggaaaa acggtcttta ttagcttcca gctcattaat
     7021 agagtggatc gtaacatatt gaggaacaac cagtccgacg cgagcttctc cgtatacctc
     7081 cccaaaaaat tcgatgctgt ctccatactg atccatataa tctttcatcg ttattggtaa
     7141 ccatgcatcc agaaacacat ctgatttctt tcctgacata gatacaaaaa taggggcaag
     7201 atcagcattt tgcaattcaa cctcatatcc atgctcttcc aataccacct tagccaaatg
     7261 actcatggca ataccttcca gccaattggc ataggctatt tttactttct ttttctctaa
     7321 gtctgaatta gtacaggaag ctagcaaaag catagctgac aatactattc ctactatttt
     7381 atatattctc atacgtattt tatcctttcc gtttagttct tattttttcg tcctgccatt
     7441 ccttgcgtga tacggtctaa gatgatagct aaaataacaa ctgctatacc accttcaaac
     7501 ccaagtccga ttttcatttg ggtaatacct ttcaatacaa tttctcccag accaccggca
     7561 gcaatcatgg cagcaattac aaccatagaa agcgacatca ttattgtctg gttgacacca
     7621 gtcagaatgg tgggcaacgc caaaggaagc tgcactttat acaataactg ccaacgggta
     7681 gctccgaacg aacgggaagc ttccactaca tttttaggaa cttgccggat tcccaatccg
     7741 gtaaggcgga ccacaggagg catagcaaag ataatggtgg caaacactcc tggcactgct
     7801 cccaatccga aaaacaaaac agcaggaatc agataaacaa aagcaggcat cgtctgcatc
     7861 aagtcgagaa caggacggag tattttctct gcacgcgaac tgtttgccgt ccatactcct
     7921 aaaggtacac caacaatcag ggccagacag gtagatgaaa aaacgagagc tagagtttgc
     7981 atggtagcct cccagaatcc cattccatag atcagtaata atcccaatgc ggtgaaaatt
     8041 gccgtaccgc gtcctgcttt catccatgcg agtgcagcaa gtaccaaaat ggttatataa
     8101 aaaggtattc cgaaaagtat gtgttggaat cctataataa aactaccgat gcccgcattc
     8161 acggcatcaa agaaagtgga aaaatgtatc atcatccaat tgatggccat ctctatatat
     8221 tgtcctatat ttatcataaa tctattgcgt tttgaattat ttcgtttatt tcttctttat
     8281 ctttcccggt cacttcgatg attaaggatg aaagcgggat tgttcctaaa aactcgcgcg
     8341 tctcatcaat cacccatacc ggcgaattgc tctttgtcat tagaggaagt atatcctcca
     8401 acaccgtatc ctccaacaca gaatgtactt ctgtacgcac aatcgtttca atggattttt
     8461 cctgtttgct acgtaactta agcaagtcgt tcagacgtac ttctccgacc agtttatcat
     8521 cggcgtctat gacaggtaat acggtgatat tcttcgcacg catcttacga atcaatactt
     8581 cgggaccttc tttcttcaga cgggccacca acggtttgtc aatcattaaa gaagaggcgg
     8641 taataatttt gctcctatcc acgttttcaa caaaacgggc tacataatcg ttagccggtt
     8701 cagtcaggat ttcctccgaa gtacctacct gcaccacttc tccgtctttc atgatggcaa
     8761 tacggtcacc tagcttaatt gcttcactca agtcgtgggt aataaaaaca atcgtctttt
     8821 tcatctttga ttgcaaggcc agtagttcat cctgcatctg tacgcgaatc agaggatcga
     8881 gagcagagaa agcctcatcc attaaaagca cttcaggatt attagccaga gcgcgagcca
     8941 gtccgacacg ctgttgcatt ccaccggaaa gctcgcctac catctgattt tcatatcctt
     9001 tcaatccgac aagcttcatg ctttccatcg ctttcttctc acgttcctct ttcttcactc
     9061 cctgaagttc gaggccgaac gcgatattgc tcaatacgga acggtgaggt aacagaccga
     9121 aattctggaa aaccatcgcc agctctttcc gacgaacctg caataattct ttttcggaaa
     9181 ttttagatat atctactccg tttacaagca cttgcccggt agtaggacgt atcagacgat
     9241 tgatacaacg cagtaatgtc gattttccac ttcccgagag tcccattatc acgaaaaact
     9301 ctccttcatt aattgaaaga ttggcatctt tcactcctac cgtacaaccg gtatctttca
     9361 gaatttcctc tttactctta tcttttttca acatcttgag ggctttctgc ttctcgttac
     9421 caaagataag gtacaaatcc tttatttcta ttttactcat ataatatatt ggtttagatt
     9481 ataatatttg ttttgttttc aactgccgca ttccttattc tcacttacga taaacaagtt
     9541 gaatgttcgc atggttcagt catgtcacat gataacatga cggtccgacg ttttttaaat
     9601 ggttaaaaaa aaacagacag agtagtttaa aaggaataga atttgataag attatcctct
     9661 taatgaacag tagaaaacag tattttcata aataaataac agtctgttct tgcatattgt
     9721 tggcacaaag gtaaggaaaa tagattaaat atgcaaattt cattcaggta cggagtaatt
     9781 ccaaagatgc tttttcaagt ctacgcatcc attttgtttg aaagagatcc cttcttccaa
     9841 caagagttgt ttctgctctg tccaacccgg aacaagccgt cccgacgcat tgacaacccg
     9901 atgacaaggc gcagataaat catccggaat ctgtttcaaa gcacgcccca ccatacggga
     9961 acattgagac attcccaata atgcggcaat tcccccatag gtagaaactt tacctaccgg
    10021 aatttctcgg acaacctgat acacctcttg acaaaaggat gcggaaaggc tcgccttatc
    10081 tactttataa tctttcatca ctcaaacatt actttatttc agttccaaaa ctagataaaa
    10141 agaaaagaat ttgcaaataa taaaagcatt tcaaataaaa tatgcaactt tatttgcttt
    10201 atttacaaat aatcccgacc tttgtaccca ttaaaagcaa ccctattatt aacaaaacaa
    10261 gcactgctgt tatgaaaaag aaaactatcc tgttcgcttc ttgtttattg ggagcactgg
    10321 ctttcagctc ctgtgagaag aacctttatg atgaaagtaa acaacccgag aaagaaaaga
    10381 agatgactga cttggaagta cctgccgatt tcgactggaa aggttctcaa aatgccaaag
    10441 tgaaaattgc cagtcaatca actgctacta tttctgtatt tctagaagaa aattgcaatg
    10501 aagaggcttt gatgcttcga atggatgtcg atgccaacac atcaaaattg gaactcccaa
    10561 ttgaaattcc tgcatatata aaaaatgtgt atgtaaaata tggtaatggc tctgaaatac
    10621 aaactgttcc tgttgaaagt aatggtacta tttctatagt agtacctgct aacgctacgg
    10681 cattatccag agttaccaca agagctaata aagaagttga aacgaacaac atcttcaatt
    10741 atccgggata tggcaacgga actattatgt tcgaagatat gtatccagct ttaggcgatt
    10801 atgattttaa tgattttgtt gcatggtata atttccaaat tgacggtttt tattggagtc
    10861 acaatcaatg ttatgcagaa tacttaatga taggattcca aatcagagct ataggaggta
    10921 tatatgacta caatccttat atccgcttgg cagaagtaca atataatgaa cttgatttag
    10981 aagaaactca aatgtatctt gagcgtaaca atcctgaaga ggctgaaaat atcaaaatcc
    11041 taaaaggccc aaaaggggaa ttgattattt cactaaagaa accggccatt cctaacggat
    11101 acaagtatta taatacggag gtaaatgaaa aaacaaagcc taaaaaaatg atggccattt
    11161 acttggtgtt caactcacct gttaacgtta aaagcctaca agacagtaaa atggactttt
    11221 atattgcaaa aactaataaa ggacaagaaa tccacttaaa aggttatagc ccggtttatt
    11281 ataacagcaa cgaaagttat gtaaatgaag acaactttat atggggatta aaagtacctg
    11341 catctttaca tcatgccaga gaagaagtaa acttcttgga agcatatcca gactttgaac
    11401 aatgggtaac atcgggaggt caagagaacc aaagatggtg gaataagcca aaaacgaata
    11461 agttgattat gaattaataa atatacagta aatcatatac tgaattaaat aagaggtaag
    11521 gtatgtcaat agatttcctt acctcttatt tttatcatat gaattctaga agtataaaca
    11581 gataaatgct caccaccaaa ttttgcagat tctatcctat cctttcctct tcaacaaatc
    11641 tgtcggactc tctccaaact gttctctata acatttagta aaataagaag gagaactaaa
    11701 accaacttca taacctatct ctgccactgt catatccgac gaagcaagca gggaagcagc
    11761 tttcttcaaa cgagctatac gaagcagttc attcggggaa taattagtta gggatttgat
    11821 tttgcgatag agttgcacac ggcttaatcc catatcttta cccaagtctt ccacattcaa
    11881 atttgaatct cccatctttg cctcaatcaa agctttgaat ttttccacaa agtctttatc
    11941 catatcacag acatcctctt tcgccaacgt ttgtccgtca ccaaaaaact gtttcaggcg
    12001 gcggtgtgaa tctatcagat tacgaacgcg tgccaatagt aattgcgaac tgaaaggctt
    12061 ggagatataa gaatctgcac caccatcata cccttgaatt cgttgttcat ccaaagaaca
    12121 agctgtcaat aggataacag gaatatgaca ggtttgtaat tcgcttttca agcgacgaca
    12181 acattcaatt ccatccattc cgggcatcat tacatcggag ataatcaagt ccgggacata
    12241 tttcatagct ttacgaatac cttccgagcc gtctgcagct tctataacag tataatcagt
    12301 atgaagcaat ccatgcacat ataagcgaat atcagcgtta tcatcaataa tcagaacgca
    12361 aggtttggaa gagtcgtaac ttttttccaa ttcctcttct tcgtaagtta aagcatcatt
    12421 caagctcgaa gaaccggaat aaccggaagt tgcaggagtt gccggaaccc cagcaacggc
    12481 agaggttgta gcatcggtgg aggttacaga agtagcagac acagagaatg ccggagagtt
    12541 ttcagaaaca acagtctcgc aagtctgcac aggcaaatca acggtaaaga tagttccttg
    12601 cttttcatca ctttccaccg tgatggtacc tttatgcaat tccacaaaag cctttaccaa
    12661 tgccagtcca atacccgaac cggcatggtg catatctatc ttatagaaac ggtcgaaaat
    12721 attccggata tgctccgcag aaatcattga accggtattg gcaacggtaa agcgaatcca
    12781 gcaatgatcg tctttagtca gggaagacaa gcgtacagtt acttttccgt tttccggagt
    12841 aaatttgaaa gcgttggaaa ggaggttgaa atagatgcgt tccaactttt ctacatctgc
    12901 caatgtgcgg taatccgtat ccggcatata atcgaatgag aaatgaatat gcttcttccg
    12961 ggctactgcc atgaaagatt cgttccatcc ttcaaaagaa gaaagaatgt ctaacgaaat
    13021 aggagtatat tccatttttc cattctcgta tttacgaaaa tccagaatct gattgacaag
    13081 acgcaaaagg atattcacgt ttcgctgaac taacaataac attcggcgct gatcttcact
    13141 caaagacgaa tcagccagta aatgctctac cgggtcggca actaatgtca gtggagtacg
    13201 aaaatcgtga gatatatttg tgaagaaaac cagcttggca tgagtcgctt cttccagttg
    13261 atgagaaagc tggataagct gatcccgttg ctcttcgagt ttatcgcgct gttgctctac
    13321 ttgtttcttc tgttcggaca actctttatt caggcgattc ttggaacgga gggatttata
    13381 gactaccaac aacaatcccg ctactaataa aagaataacc aagccgccat acatcacgac
    13441 ctgctgcgta gctacacgcg acagataccc accgatacgt ccgttcaatg tttcaatctt
    13501 ctgatccagt tccgagatat gggtagtctg aagttgcata acgtgcgcgt tcgtgcggtc
    13561 tacaacggca gtattcatga ccgtttcgcg aggataagac ttcttctcaa gaatattcat
    13621 ggccagttgc atcactttgt ccccattagt cggataaata aaagttgcat ccagcacatt
    13681 gtcaagcacc aattcaagcc cgtttccttt gccgggcagg gcatcaatgc caacaaaaat
    13741 cattaccttt tcacgtccgg ctttcttcgc agcttgatag gctcccggag cgatacggtc
    13801 gttatgtgca tataccgcat caatcttcgg atgacggcga agcatactat ccatttccac
    13861 ttctgccggt tcacgttccc aggcagcatc cgctttatca atcagtttga tatccggata
    13921 attgctgata gcagccataa atccctgatg gcgttccatg gcaggggtgg aaccacccag
    13981 tccggtaagc tccactacat tccctttccc tttcagactt gatgcgatat aatttcctac
    14041 cgcacgacct atttcataat tatcggcacc gatataggca gtatatttat cagaaagtat
    14101 cttccggtct acaagaatga caggtattcc tttctgatag gcctcctcca caattggagt
    14161 catgggagcc gcttcattgg cggaaattat cagtaaatca actcctttat ctataaaata
    14221 atgaacatct tccgcctgct tacggttatc atccgccgcc gagcggattt caaccgacac
    14281 tccatcataa aacatcgctt cgcgaagaat ctcatcattc atcttgtgcc tccaagagtc
    14341 atcgctacat tgggccaccc caatacggaa acgaggcgca tcctgccgac aggccgccaa
    14401 gcccaaaaga caaaacaaga ctgttatcca cttcgtatat ttcatcgctt caatcattcc
    14461 ctttctttcg tatatctttt gtatttcttt ctgtaatcca aatttctccc cccgcattat
    14521 ttgcattcac caccgggaaa tacatcagtt ccactttcac agggttcagc gtatattttc
    14581 cagtaaagcg tggaagcaaa ggaaccgtaa actgataagt acctaccggt aatttttcgc
    14641 taaagataac agttttctct ttaaaatact cacgatatac ttcagaacgg gagaaattaa
    14701 caggttttga ggcataacta caacctgccg gaacaggaac ttcgagcatc acatattgcg
    14761 caccctcctg tttcacctgc aaggtaactg tcaatgtaac aggtacaccc gccaccaaag
    14821 agtctttttc caaagtcacc tccaccttga aagcatcact ctgacgagca ttcatcacac
    14881 gcttcattga atagacacta tacaataaag gctcttttcc cgtttttgaa ataagcagac
    14941 tgtcgcttgc tgtcagccgg gcatgataag gaaattccgt aattcgttga tgatccttac
    15001 cgctcacaga caccgacgtt cctgacatcc ctccggaacc tgccagcaaa tcggtcagaa
    15061 cagttgccac agccgaagaa gcctgatacg tattccatcc gcgctcctta gtccgcaaaa
    15121 tatacaattg catattttct ttcaacttac acagggaagg gtcattttta ataatccggt
    15181 aggctatcaa tgtatttatc atctgatttc cctcccaata ataagtacgc cgtccgtcgt
    15241 cacagtaaac accttccagc atatcctttt tcagataagg acgtacgcta tcacccacat
    15301 tcaccgaatc cacctgttgc ttgatttccc agagaagcag cttctctttc aagtatgaaa
    15361 gaggacgata atacttgttt ctatttgcca acgagtcttc tttctgttcc aattgccgga
    15421 cgaaaggttc caataatctg actgccgaag aataatccgc ctctactttc cactcatgca
    15481 gagcatgaag tatttctata tcttccagtt tcattcctcg ataaggacgc gtatgagcat
    15541 actccacttt caaaccattc agattcaact ccacaggata acctgcatct tgcgccatct
    15601 tcaaagcccg cagaatatgc gcagacatcc agaaagaagt attttcagag ttcccccacc
    15661 acgaccataa ctgatgtttg ttctgatgat tcgtcagtcg atggatgata ggtcgaattg
    15721 ctttatctac tttcaccttt tcacccttac tctgcatata ctgttggtaa gccaacaaac
    15781 cgattaactt ggatgccagc tgctcattgc acaaatattt gtatcctgtc aagtaattca
    15841 ctgattcttt atagatgtcc aactgattgt cagtgatact caccatcact tcttcatcct
    15901 cgccggattg cactttaacc gtctttgcat cggacagaat acccaatgtg ccctccgcca
    15961 attcagttcc ctgtgccagt atcggaatcg tatattcctc tccatcctga tagccatcgt
    16021 cgcgagtgaa aagatagctg atggtcacgc tatcggcatg aactgcctgc atcggcactg
    16081 tttcatgaaa tccctccatg aaactcactt cctgccgttt caacgtatcc gttccgacgc
    16141 agaactgtgt ctttccggct atgtgctgcc catccagata attgcggata gtcccgacca
    16201 ccgtactctg atccccctcc accaagaagc ggggagtttt caactccgcc atcaacggtt
    16261 tgtaagagcg gacgaaacgt cggaaagtac ccgtctgcaa acgacggttc atgccataaa
    16321 cgacagtttc ccatttcgtc acattatcgg ggaaagttgt ttcaaactgt acc
//
