LOCUS       gnlProkkaBINKJMGP_21   14484 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BINKJMGP_21.
ACCESSION   gnlProkkaBINKJMGP_21
VERSION     gnlProkkaBINKJMGP_21
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 08:44:37
            Original ID  :: gnl|Prokka|BINKJMGP_21
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 107643
            Orig. end    :: 122127
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14484
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14484
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14484
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2132..3142
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_70"
                     /sec_met_domain="PF04055 (E-value: 1.1e-17, bitscore: 57.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
     CDS             3161..4201
                     /locus_tag="ctg13_71"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGEASKE
                     AEQTNK"
     CDS             4206..5300
                     /locus_tag="ctg13_72"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5310..6551
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg13_73"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6538..7065
                     /locus_tag="ctg13_74"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7071..7844
                     /locus_tag="ctg13_75"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7851..8267
                     /locus_tag="ctg13_76"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPATETPAPAAE"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 95.3; E-value: 4.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg13_77"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGYTDEGGAFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSLMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_78"
                     /sec_met_domain="PqqD_RRE (E-value: 6.1e-11, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.2e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(10534..10818)
                     /locus_tag="ctg13_79"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLTRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10855..11922)
                     /locus_tag="ctg13_80"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELTSVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPTVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11995..13506)
                     /locus_tag="ctg13_81"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 gggttttcac aagtggatgc caagtcgttc tcaaagcaat atttgtctac ttactccaag
       61 gcattgtccg cacagcagga agatattctt gcttcgtggg tgctggccag acaaccgcgc
      121 tgtttaagtg tattgctcaa tgagctggtt tcgttcggtc agtatgatgc tctaaatgaa
      181 tatatgagtg gatattgtcg gctcaatgag attgagcaat tctacgacag tgtgcttcgg
      241 cgtttgtcgt ccgattatgg tttcgaggag attggaagaa cgcttctaat gctttcactt
      301 actttagaag gatttaccga agatgaagta aagagcatgg cagacattaa tcagatactt
      361 tggtcgcagt tgagagtgga aatgagcagc tggctcacca acaaaggagg acgatattgc
      421 attggtgaca cacaaatggt agaggcgatc gaacgctatt tcgctcaaga tgacgaatgt
      481 atagatgata gtcgccatga aattatttcc gctctgctgg atgaggaaga aatcctttcc
      541 catccgttga cttttgccga ttataactat cgcatgaaac agttctgcta ccatgattcg
      601 tatcgctata aagtggagat tacctatcaa tgctataaga tgcaagaatg ggatatattg
      661 aaggattgga tttgtgatgt ggagattttc gagattctgt atcgcacgaa tcgttctctg
      721 ttggaagata gctggaaggc gatcatgaac gacaatcctg aagttacgcc tgaagtctat
      781 gccgaattgg actttgatga gatcgattct tttttaattc ctgtcattgc taatgatatg
      841 gctactttct tgagcagttc tttccatctg acgaaggcgg cagctgctgt gagtgagaag
      901 agtatggaag gtgctgccat gccactcatt gccaagtcgg tattgaagat gaatgaggga
      961 tgccggtatg cccgtaatga agaatacgaa acggcatgcg actgtttctt gaaagcattg
     1021 gtgatgcagg aaaacattgt accgactccg gaactggaga ttgccaacac ctgccgaaat
     1081 ctagctctgg catattacta caatgagcaa tacaatgaag cagtgaccta tctgaatagg
     1141 gcgcttgatt atcatgcggc ttctgctgat gagaagagtc aggcagaagt cattgaactt
     1201 tccgaatatc tggcttattg tgattactat aaggatgagg aagagagggc tgccgagaaa
     1261 ttccggaaag tagctgaaat gcacgagtcg ttgaatggca gactgtccgg tggagtggct
     1321 aaatgtttgc gtatgcaggg taaatgtctt tattatatca aacgatacga tgaagcatgg
     1381 atgctgatga atcaggcgtt ggacattgct atacagatag atagtaaaaa acagatcgtc
     1441 gcttgtcata aacagttgta ttatctgtgc agggaattca aacggatgat gaatgaacgt
     1501 ggcgatgagc aggcatctac tttattcttc cgtgagtctc ttctgcatga aatgtatttc
     1561 agcgaaaaac cgcgtctggc ggaactgact gtccgctacg aggcattgag atgtgatatt
     1621 atgcagcagt attacatgaa taaagactat gataacgtga ttcgtattgc aacgtctttg
     1681 gatattcatg atgatgctga ccctaatgct tcctgtctgg tatattatta caaagcacag
     1741 gcttatgtga agttggagaa ttatccaatg gcgaaagagg ctttcttcag agaacttgaa
     1801 ttgcgaaaga agtatttggg atgggaggaa gaagatacga ttctggcttg tcagaactta
     1861 ggggttttgc atagcttttg taatgaacgg gaagaggcgc tggcttgttt ccgtgaggcg
     1921 tacggttatg aagtgaaaaa gaatggcgag gattctgaaa tggcgcaaaa gctacttcaa
     1981 tatatcagcg tggttgaatc ataacggagg catacttccc ttttttgtta acttttacat
     2041 tcctgctata cggaaatcga ctttatttcc ttacatttgc agatataaac tatcaacaga
     2101 aagaagaatg tctaaatatc cccttttagg aatgactctt gtagagcttc aatcattgac
     2161 aaaaagactg ggtatgcccg gctttgctgc caagcagatt gcatcctggc tttacgaaaa
     2221 gaaggtagcc tcgattgatg atatgactaa tttgtcattg aaacaccggg agttgctcaa
     2281 gcagaactat gaggtgggag cggaagctcc ggtagatgaa atgcgctctg tagatggtac
     2341 ggtgaagtat ctttataaag tgggtgagaa ccattttgta gagtcggttt atataccgga
     2401 tgatgaccgg gcaacgttgt gcgtgtcgtc acaagtaggt tgcaagatga actgtaagtt
     2461 ctgtatgacc ggcaaacagg ggtatacggc taacctgacc gccagccaga tcataaacca
     2521 gattcattcg ctgccggaac gggacaaact gactaatgtc gtaatgatgg gaatgggcga
     2581 gccgctcgat aacctggatg aggtattgaa ggcattggaa ctactgaccg ctacctacgg
     2641 ttacgcatgg agtccgaagc gtatcacgct ttctacagtc gggctacgga aaggattgca
     2701 gcgttttatt gaagaaaatg actgccacct tgccatcagc cttcactctc cgctgaccgt
     2761 tcagcgtgct gaattaatgc cggcggaaaa ggcgttttca atcaccgaaa tggtggaact
     2821 gttaaaaaac tatgatttta gtaaacaacg tcgactttcg tttgaatata ttgtttttaa
     2881 agggctcaat gattcgcagg tctatgccaa agagttgctg aaacttcttc gcgggctgga
     2941 ttgcagggtg aatctgattc gttttcatgc cataccgggg gtagacctcg agggagcgga
     3001 catggatacg atgacccgtt ttcgtgatta tctgacgtca cacggacttt tcaccactat
     3061 ccgttcatcc aggggcgaag atatttttgc cgcttgcggt atgctgtcga cagcgaaaca
     3121 ggagaaaaat aatgaaagtt aatatataaa accgaacatc atgaaaaagt actcttttat
     3181 tttatgcatc gctttggtag cctttgtcgt tgcatcttgt ggtctgaaag gaaatcacac
     3241 ctctagtggt cgtgcttacg agcttttggt tgtagtagat cacggtgttt gggatcgtgc
     3301 tgccggaagg gctttacatg atgcgctcga tgctgatatg cccggtttgc cgcagtcgga
     3361 accttctttc cggattatgt atacttcacc gaaagattat gattctacgc tgaagttgat
     3421 acgtaacatt attattgtag atatacagga tatatatacg aaagcctcgt tcaaatatgc
     3481 gaaggacgtg tatgccaatc cgcagatgat attgactatc caggctccga acgaagaaga
     3541 gtttgagaag tttgtggaag agaacaaaaa gacgattgtc gacttcttta cccgtgcgga
     3601 aatgaaccgt cagattacgt tcctggaagg gaaacacagt aacttcattt cgcagaaagt
     3661 ggacagtttg ttcggatgcg acatctgggt ggatgccgaa ctggctaatt caaagaccgg
     3721 ggatgatttc ttctgggctt ctaccaacac aggtagtgcc gaccgtaact ttgtgatgta
     3781 ctcttatccg tacactgaca aggatacgtt taccaaagaa tattttgtgc acaaacgtga
     3841 ctctgtgatg aaagccaata tccccggatt caaggaaggc gtttatatgt cgaccgatag
     3901 tttgctgacc gatgtccgtc cgatcaatgt acagaacagc tacacaatgg aagcacgtgg
     3961 cctgtggcgt atgaagggcg actttatggg tggcccgtat gtatctcata ctcgtctgga
     4021 cgagaaaaac caacgaatta taacagcaga aatatttgtt tattcacctg ataaaatgaa
     4081 acgcaacctg gtacgccaga tggaagcatc tctgtataca ctgaaacttc cgaatgaagt
     4141 tcagcagaat cagattccat tgggagaggc atctaaggaa gcggaacaaa ctaataaata
     4201 aaaacatgga agataacaag ataaggatag gtatcaccca aggagatatt aacggggtgg
     4261 gctatgaggt gattcttaag acattttccg accctacgat gttggaacta tgtactccga
     4321 tcatttatgg ctcaccgaaa gtagcggctt atcatcgcaa agcgctggat atacagacca
     4381 atttcagcat tgtcaactct gctaccgaag cggggtacaa ccgtttgagc gtggtgaact
     4441 gtacggatga tgaggtgaaa gtggaatttt ccaaacccga tcccgaagcc ggtaaagctg
     4501 cgcttggggc tttggaacgt gccatcgaag aatatcgcga agggctgata gacgttatcg
     4561 taacagctcc gatcaacaaa catacgattc agtcggaaga gttctccttc cccggacata
     4621 cggaatatat cgaagaacgt ctgggcaatg gtgataagtc attgatgatt ttgatgaaga
     4681 atgacttccg ggtggctttg gtgacgacac atatccctgt tagagagatc gcgactacga
     4741 ttaccaaaga actgattcag gagaaactga tgatattcca tcgttgtctg aaacaggatt
     4801 tcggtatcgg cgctccgcgt attgcggtgc tctctctcaa tcctcatgcc ggagacggtg
     4861 gtttgttggg aatggaagag caggaagtga ttatccctgc catgaaagaa atggaagaga
     4921 aaggaatcct ttgctacggt ccttatgcgg ccgacggctt tatgggttca ggcaattata
     4981 ctcattttga cggtatcctg gcgatgtatc acgatcaggg gctggctccg ttcaaggcct
     5041 tggctatgga agacggggtg aactatacgg caggcctgcc ggtagtacgt acttctccgg
     5101 ctcatggaac ggcatacgat attgcaggca agggattggc ttgtgaagat tctttccgtc
     5161 aggcaatcta tgttgccatc gatgtgttcc gtaatcgtca gcgggaaaaa gtggctcgtg
     5221 ccaatccgtt gcgtaaacag tattacgaga aacgtgacga tagtgataaa ctgaagctgg
     5281 atacagtaga cgaagattaa aaacgagtga tgacgagagc agagatacaa caagtgaaac
     5341 agcgtttcgg tattattgga aatactgaag cattgtcgcg cgccatagat gttgccattc
     5401 aggtagctcc taccgatttg tctgtgctga ttaccggaga aagtggagtc ggaaaagaaa
     5461 gttttccgca gattattcat caatatagcc ggaggaagca cggacagtat attgctgtca
     5521 actgtggtgc tattccggag ggcacgattg attccgaact gttcgggcat gagaagggtg
     5581 cgtttaccgg tgcgattggc gaacggaaag ggtactttgg cgaagccgac ggtggtacta
     5641 ttttccttga tgaagtaggg gagttgccga tgcctaccca ggcgcgtttg ctccgtgtgt
     5701 tggagagtgg cgagtttata aaagtaggtt cgtccaaagt gcaaaagacg gatgttcgta
     5761 ttgtggcagc taccaatgtc aatctgacac aagcgattgc agaaggacgt ttccgtgaag
     5821 atttatatta ccggttgaat acggtgccta tccaaatacc gcctttgcgt gaacgtggtg
     5881 acgatgtact tttgttgttc cgtaagtttt ccgcagactt tgcagagaaa taccggatgc
     5941 ctgctatcca gttgacggag gatgcgaaga aagagttatt ggcttacccg tggcccggca
     6001 acgttcgtca gttgaagaac atcaccgagc aaatatctat cattgaaacc aacagggaga
     6061 tctctgctgc tatcttgcag aattatcttc ccgcacaaaa tacgcaacgt cttcccgcgc
     6121 tgatgggaac gcgtgagagt aaaggctttg agagcgaacg ggagattctt tattctgttc
     6181 tgttcgatat gcgccaggaa gtggcggagc tgaagaagat ggtgcacaac ctgatggcgg
     6241 aacgtgccgg acaggtgggg caggtaggac aagtgggaac ggtggttact actccggtag
     6301 tgacgacaca ccagccttcg gtacctgcga tcattcatac catgcagcct gcggtttgca
     6361 aggatgacga tgacatacaa gacacggaag aatatgtaga agaacctcct ttgtcactgg
     6421 acgaagtgga aaaagaaatg atacgcaaag cacttgaaag gcatcacgga aagcggaaga
     6481 gtgcggccaa ggacttgaat atttccgagc gtacacttta tagaaaaata aaagaatatg
     6541 aattggatta agaaaataat acgccctttg ctactgttcg gcttgccgtt ggtagtcatt
     6601 gcgtgcactg tttcctataa gtttaacgga tcgtctatca attatgataa ggtaaagacc
     6661 atttcgatag ccgacttccc gatcaagtcg gagtatgtat atgctccgtt ggcaaccaaa
     6721 ttcaatgagg acctgaaaga tatcttcatc cggcagaccc gtctgcaact gctcaagccg
     6781 agtcaaaatg ccgacttgca gattgacgga gaaatcacag ggtacaatca gtacaaccag
     6841 gcagtatctg ccgacggtta ttcttcggag acgaagttga ctatcaccgt caatgtgcgt
     6901 tttgtcaaca acaccaatca tgccgaagac tttgaacaac agttttctgc gttccgtacc
     6961 tacgactcta cccagttgtt gactgccgta caggacggat tgattgctga aatgtctaaa
     7021 gagatcaccg accaaatttt taatgcaact gtagcaaact ggtaatataa atgacttctg
     7081 ttaactttca acaatggatt cagcatcccg agacgctgaa tagggatact ttgtacgaac
     7141 tgcgcaatct tcttgcgagg tatccgtatt ttcagtcact tcgtctgttg tatctgaaga
     7201 atctgtatat tctccatgat attagtttcg gtggagaact gcggaaagca gttctttaca
     7261 ttgcagacag acggcagttg ttccggttga ttgaaggtga ccgctatgat gtgcaggcac
     7321 ggaaaaaggg agtacctctc acggaggtgc tgaaagacga accgtccgta gaccgcacat
     7381 tagcattgat cgacgctttc ttgtccacag tacccgaaga ggtgactgct cggaccagtt
     7441 tcgactattc gatggattac acctctttcc ttttggagga gactccggcc acggaacagc
     7501 cggctgaaga aacgcccaaa ctcaaaggct tcgaactgat tgacgatttt atagaaaaga
     7561 gcgagagcga ctctcccctc tgcatgaaac ctttaagaga agaaatgcca tcttcgccaa
     7621 cctcttcgga cgaacttacc gaagaagaaa cgatgaagga agaagaggaa gatgacagct
     7681 gttttacgga aactttggca aaaatctatg ttaaacagca acgatattca aaagctcttg
     7741 aaataattaa aaaattaagc ttgaaatatc caaaaaaaaa tgcttacttt gcagaccaaa
     7801 tcagattttt ggagaaattg attattaacg ctaattcaaa ataactaaaa atgtacttat
     7861 tattcgttat cttaatggtt attgcagcct tgttgatgtg tttcatcgtg ctgattcaga
     7921 actcaaaagg aggcggactt gcttctggtt tctcttcatc taacgccatc atgggcgtgc
     7981 gcaagactac agactttctg gaaaaagcaa catggggcct ggccatcttt atggttgtaa
     8041 tgagcattgc tactgcttat gtagttcctc gctctgctgt tgctaaagac gcagtgttgg
     8101 aacaggcaca gaaagaacaa cagactaacc cgtataactt acccgcaggt acggctgcgc
     8161 cgcaaactga agctcctgct accaatgcac ctgctacaga aactccggca cctgctacag
     8221 aaactccggc accggctact gaaactcctg ctcctgcagc agagtaattc actccgtcgt
     8281 caggtaagac tttggggtaa aaccattaat gggaaggtgc agacggatgc tgcatttctt
     8341 tgatatttaa gtgcggatta cgcagattac acggattttc aatgttccga gtggtcagtg
     8401 taatccgcac ttaacttttt cttgtaaaaa caatctcttt gtgatagaaa caaacgagat
     8461 ttaactacct ttgttggctg tataagatta ttaactactt ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactatt atgggatagt cttgattatg gattcttcac aagcgcttac
     8701 ggttggttta acgtattctt gttgatgctg atcttcggtg gtatcatttt ggacaaaatg
     8761 ggagttcgtt tcaccggaat gggagcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tcttcggatt caaaacacag
     8881 gtgacgttgg ctgcattggg atatgctatc tttggtgtag gtgtggagat tgctggtatc
     8941 actgtttcca agattatagt gaaatggttc aagggcaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tattgggaca actctggcga tggtgttgac agttcctttg
     9061 gcagacttct tcggatatac ggacgagggt ggtgcattcc ataccaatat tcctgctcct
     9121 attctgtttt gtctgattat gctgtgtgta ggtactattg ctttcttcct ttatactttc
     9181 tacgataaga aattggatgc ttctttggat gcagaaggtt tggaaccgga agaaccgttc
     9241 cgtatgaaag atattgtgta tatcattacc aataagggat tctggttgat cgcattgctg
     9301 tgcgtattgt tctactcggc cgtcttccct tttatcaaat atgctgccga cttgatggtg
     9361 cagaaatata atgtagatcc gaaactggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcaattatcc tgactccgtt gttcggttcg ttatatgacc gtatcggtaa aggagccaca
     9481 ttgatggtga tcggatcatt gatgctaatt tttgtacata ccatgtttgc cctgcctata
     9541 ctgaatatat ggtggtttgc tactattata atgattatat tgggatttgc tttctcattg
     9601 gtgccttcgg ctatgtggcc ttctgttccg aagattattc cggaaaaaca gctgggtact
     9661 gcttacgctt tgattttctg ggtacagaac tggggactga tgggtgttcc tttgttaatc
     9721 ggatgggtat tgaatactta ttgcaaaggt ccggtggtag acggtgcaca gacttatgat
     9781 tacacattgc cgatgactat ttttgctctc tttggtgtac ttgctctgat tgtggctttg
     9841 atgttgaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tatccaaaag
     9901 taactgggaa attcaatacc taaagtaaca aaggaatttt gtatcaaggt gtaaacaaaa
     9961 gggtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accattttca
    10261 aaatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagtcgcata aataggaatt tatatttcac cacagaggac
    10381 acggaggaca cagagttctt ctctctcttt ccgcaagtaa aacagagcga taaatacgat
    10441 tctcaatacg tgagactctg tgttactcta tagtgaataa aaaagattaa acctctgtgt
    10501 cctccgtgtc ctctgtggtg aatttattat tatttatttg ataaatacag cccaaagtat
    10561 gacggcaatt gctatcagga ctcccatgat aataagcgtt ccccaaacaa aataattgct
    10621 gtctttctct ttctttttct ccgagtcgtg gatgatacgt tccatttctt cgggagtggt
    10681 attgggtagt ggataaggtt cgtttgcacg ggttaaatgc ttcaacttgt cgttagcacg
    10741 ttcacgacgt aggcgggaag cttcccgtcc ctcttttatt cggcgtatca tgtcgaatgc
    10801 atgtccttca ccaaccatat tctttgtttt ttagaagttc actttctcgt ttttctattt
    10861 cccttcttct ctgtccactt tgagcaatcc tcccgtattc ggatcaaaat aaactttgat
    10921 ggtagaattc ttgttgaaca aaaccggagc cagatattct atcacaccaa attgagtaat
    10981 aggaagttca ccttcgtaaa gtttcttttt gccgtcggtc aatgtaacca tagcttgtcc
    11041 gggtacgttg taggcgattc catccaaatc tttcttcttc ttaccatctt cctgtggtat
    11101 cttgaccgat ttcaggtctt tcagactgat ataaaacgga gttcctgcca aatcattgtt
    11161 ggcaactaca cctaacttct tcgagaagcg gaaagcaact tcattgttaa attccttgtc
    11221 aggggtaagg cggacagtga atgttctctc ttccttgttg caggtgccgg agaacatttg
    11281 cgtcatggct tcttcctgtg cattcagatt gtcgagcata atcttaagct gtgctccgtc
    11341 tgaaggcata ttgtcagcct gtccgcgcaa taaggcattt ttgctttcgc ggatgttata
    11401 gatttcttta gccaccagtt cggccatctt ggcggtagag ctagccatca gaatctcttc
    11461 ggtcaggaat tcacgaggat ttgctttctt ttggaggact gtgggagcgg gagcggcttt
    11521 tttgcctaca ctgctgttgc tgtaaggaac attgatcgtt ttcacaatgc catcctctgt
    11581 cagttccatg agcggtgcta ctgtcttatc cttcaatttt acgaaatacg tcgtttcgct
    11641 gttgggcaca cctacggatt tcacttttac gctagtcagt tcccagtact cttcagggtc
    11701 ggcggagacg ttggtcagtc gcaggtaacg atcagcatat ttgctgaatt ctcccggagt
    11761 atagttgact ttgttggctt ttatttcaag ttctatttgg gttttgggaa gactgtaaac
    11821 cactccatag tcttttcctc gggtaacccc tgtcagtact tcggtttgtg cataggcgga
    11881 cgttgtcata agtagtcctg ctgctataat caactttttc atattcggtt ctttttaact
    11941 ggttttgaaa acaaagttaa tgaagttatt gaaaaaactg taagttctta acttttattc
    12001 gcttacaagt cgccatgctg tcggcagaca ggtgataata tcgcttgcga tcattccgat
    12061 cattccttgc ttcttttgag cgacatcgcc cgccaatccg tgaatgtaag tgccgatttt
    12121 agcggcttct tcggtgggat aaccttgggc aagcagcgcc aggattactc cggtcagtac
    12181 gtcaccgcta cctccggttg ccattcccgg atttccggtt gggttgaaga aacatttacc
    12241 ttctggggtg ataatggcgg agtaggctcc ttttaaaata atgtggacat gggcggcacg
    12301 ggccagttcg caagccttca tcagacgttc gtaagagtcc tggcatttgc cggtcagacg
    12361 ttccagttct ttcggatgcg gggtgaggat ggaacccttc ggcaggtggg taagggtatg
    12421 gcggtggttg gcgaggatat taagagcgtc ggcatccact acaacaggag tctggcagtg
    12481 ttccagttgc tccaacaagg cagcttccgt ttcctcgttt cgtcccagtc ccgggccgat
    12541 gccgactgct tggtagtcgt ccgtatcggt aggtacggca aaacaggttt cgttgatgtc
    12601 ggtttctacg attgcttcgg gtatggaggt ctgcaagatg tcgttgttgc acattggtgc
    12661 atgaacagtc agcaacccta ctcccgaacg gaggcaggcg cgggcagcga gaacagaggc
    12721 tcctgccatt ccttttgaac cggcaatcaa tagtgcatgg ccgaagttcc ccttgtgggc
    12781 aaactgtttg cgtggcttga tgagtgaacg gatttcttct atttccaaca tttcgtagtt
    12841 agtctccatc tcttcaatac cgtcttcgct taattggata tccagcactt cccattctcc
    12901 gacaaattca gtgttctctg cgaaaagaaa ggcgagcttc ggcagttgca gactgaaagt
    12961 tacgtcggcg cggataatat tagcttttac gttgaatgta ttttcttctc ccatcagtcc
    13021 ggaaggaatg tcgatggcta ctaccatggc aggggaggaa ttgatgtatt tcactacggc
    13081 agcgaatcca ccgctcaacg gtttgttcag acctgaaccg aataatccgt cgattaccag
    13141 atgatcgggc gtcaggacgg gaggtacgaa ttgggtactg atttcgtgga attttacttc
    13201 ttccatcatt tctaccagtt ctttattggt ctggcagtcg ggtgaaagtt ctcctttcgt
    13261 gttgaagaga aatacctcga ttttatatcc tttttcagcc atcatgcggg ctacggcgag
    13321 agcgtctccg ccattattcc ccggtccggc aaagatagtg accggcgttt ccgtattcca
    13381 tctgtctgtg atggcttttg ttaatacggt tgctgcacgt tccatcagat cgattgatgc
    13441 aataggttcg ttctcaatgg tataagcgtc caatttcttg atactgctgc ttggaaatat
    13501 tttcattgcg atgttctttt agttttcgga ttacaaatgt acatgattct tctgactttt
    13561 cccgtttgtt gtgggaagaa aaccataatt gcaactttta attcatcatt agttctatct
    13621 tttggtcaaa gaaatatctg cttttgaact attaagtgtt agaataactc cgccaaaaaa
    13681 taattcaatg ctgcaccatt atgaacttac ttttatttct ccctgaaaaa gatttcttca
    13741 tttctcatat tctcattgtt tttcgataaa cgaaagataa tcaaatagat atcttatgag
    13801 aaacactttt tcaaaacggt atttctcata agttctccca tgttttggct caaaagccac
    13861 cttattctca tcgtatttca gggtatttct catagtcaaa agccattctt tcttcctttt
    13921 ttctttcagc ctgccttatt tttatcagga aatgaagcta ctatttagat aaaatagtgg
    13981 ctttttgctt ggagatgctc gttgttctcg attgtcccat atattgtggg aaagtattct
    14041 cgtatattga aggaaaactt tcccacaaaa taagggaata ctttcccaag ccttagggaa
    14101 tcttttccca caatatgtgg gactaagaca ctgtgtatgg aagcaagcaa aaggaataca
    14161 tagttctatt tattcaatgt cagcttccgg cacactacac tatgagaaat gaagcaaaat
    14221 ccgggttatt ttgcgaagaa actatgagaa atgcctgttt taaaatcatt tctcatagtc
    14281 tatcttatta gtttactgcc acttgtgcct tatttatgag gatatgagaa atgaaaatga
    14341 aaaatctttt tctgtaggct gaattcaagt tgtaaatgcg acccctcctt attttataat
    14401 ttcaattttt tcttgagttg cttaattttt ctaaaagttt gtgcctcttt cggtgataaa
    14461 aatcccagtc tttttcttgg tctt
//
